Effectiveness of a specific care plan in patients with Alzheimer’s disease: cluster randomised trial (PLASA study)
Identifieur interne : 001183 ( Istex/Curation ); précédent : 001182; suivant : 001184Effectiveness of a specific care plan in patients with Alzheimer’s disease: cluster randomised trial (PLASA study)
Auteurs : Fati Nourhashemi [France] ; Sandrine Andrieu [France] ; Sophie Gillette-Guyonnet [France] ; Bruno Giraudeau [France] ; Christelle Cantet [France] ; Nicola Coley [France] ; Bruno Vellas [France]Source :
- BMJ [ 0959-8138 ] ; 2010.
Abstract
Objective To test the effectiveness of a comprehensive specific care plan in decreasing the rate of functional decline in patients with mild to moderate Alzheimer’s disease compared with usual care in memory clinics. Design Cluster randomised trial. Setting 50 memory clinics in France. Participants Patients with Alzheimer’s disease (mini-mental state examination score 12-26). 1131 patients were included: 574 from 26 clinics in the intervention group, and 557 from 24 clinics in the usual care (control) group. Memory clinics were the unit of randomisation. Intervention The intervention included a comprehensive standardised twice yearly consultation for patients and their caregivers, with standardised guidelines for the management of problems identified during the assessment. Main outcome measures The primary outcome measure was change on the Alzheimer’s Disease Cooperative Study-activities of daily living scale assessed at 12 and 24 months. Secondary outcome measures were the rate of admission to institutional care and mortality. Results At two years the assessment was completed by 58.4% (n=335) of patients in the intervention group and 61.6% (n=343) in the control group. The rate of functional decline at two years did not differ between the groups. The annual rate of change on the Alzheimer’s Disease Cooperative Study-activities of daily living was estimated at −5.73 (95% confidence interval −6.89 to −4.57) in the intervention group and −5.96 (−7.05 to −4.86) in the control group (P=0.78). Conclusion A comprehensive specific care plan in memory clinics had no additional positive effect on functional decline in patients with mild to moderate Alzheimer’s disease. Future research should aim to determine the effects of more direct involvement of general practitioners. Trial registration ClinicalTrials.gov NCT00480220.
Url:
DOI: 10.1136/bmj.c2466
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001183
Links to Exploration step
ISTEX:FF52288570DE05AA74E2A5E7C8196C19258AD889Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Effectiveness of a specific care plan in patients with Alzheimer’s disease: cluster randomised trial (PLASA study)</title><author><name sortKey="Nourhashemi, Fati" sort="Nourhashemi, Fati" uniqKey="Nourhashemi F" first="Fati" last="Nourhashemi">Fati Nourhashemi</name><affiliation wicri:level="1"><mods:affiliation>Gérontopôle, CMRR, Toulouse, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gérontopôle, CMRR, Toulouse</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Inserm U558, Toulouse, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm U558, Toulouse</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>University of Toulouse III, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Toulouse III</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: fatinour@orange.fr</mods:affiliation><country wicri:rule="url">France</country></affiliation></author><author><name sortKey="Andrieu, Sandrine" sort="Andrieu, Sandrine" uniqKey="Andrieu S" first="Sandrine" last="Andrieu">Sandrine Andrieu</name><affiliation wicri:level="1"><mods:affiliation>Gérontopôle, CMRR, Toulouse, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gérontopôle, CMRR, Toulouse</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Inserm U558, Toulouse, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm U558, Toulouse</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>University of Toulouse III, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Toulouse III</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Epidemiology and Public Health, Toulouse University Hospital, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology and Public Health, Toulouse University Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Gillette Guyonnet, Sophie" sort="Gillette Guyonnet, Sophie" uniqKey="Gillette Guyonnet S" first="Sophie" last="Gillette-Guyonnet">Sophie Gillette-Guyonnet</name><affiliation wicri:level="1"><mods:affiliation>Gérontopôle, CMRR, Toulouse, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gérontopôle, CMRR, Toulouse</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Inserm U558, Toulouse, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm U558, Toulouse</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>University of Toulouse III, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Toulouse III</wicri:regionArea></affiliation></author><author><name sortKey="Giraudeau, Bruno" sort="Giraudeau, Bruno" uniqKey="Giraudeau B" first="Bruno" last="Giraudeau">Bruno Giraudeau</name><affiliation wicri:level="1"><mods:affiliation>Inserm CIC-202, Tours, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm CIC-202, Tours</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>François Rabelais University, Tours, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>François Rabelais University, Tours</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>CHRU de Tours, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHRU de Tours</wicri:regionArea></affiliation></author><author><name sortKey="Cantet, Christelle" sort="Cantet, Christelle" uniqKey="Cantet C" first="Christelle" last="Cantet">Christelle Cantet</name><affiliation wicri:level="1"><mods:affiliation>Inserm U558, Toulouse, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm U558, Toulouse</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>University of Toulouse III, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Toulouse III</wicri:regionArea></affiliation></author><author><name sortKey="Coley, Nicola" sort="Coley, Nicola" uniqKey="Coley N" first="Nicola" last="Coley">Nicola Coley</name><affiliation wicri:level="1"><mods:affiliation>Inserm U558, Toulouse, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm U558, Toulouse</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>University of Toulouse III, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Toulouse III</wicri:regionArea></affiliation></author><author><name sortKey="Vellas, Bruno" sort="Vellas, Bruno" uniqKey="Vellas B" first="Bruno" last="Vellas">Bruno Vellas</name><affiliation wicri:level="1"><mods:affiliation>Gérontopôle, CMRR, Toulouse, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gérontopôle, CMRR, Toulouse</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Inserm U558, Toulouse, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm U558, Toulouse</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>University of Toulouse III, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Toulouse III</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:FF52288570DE05AA74E2A5E7C8196C19258AD889</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1136/bmj.c2466</idno><idno type="url">https://api.istex.fr/document/FF52288570DE05AA74E2A5E7C8196C19258AD889/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001183</idno><idno type="wicri:Area/Istex/Curation">001183</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Effectiveness of a specific care plan in patients with Alzheimer’s disease: cluster randomised trial (PLASA study)</title><author><name sortKey="Nourhashemi, Fati" sort="Nourhashemi, Fati" uniqKey="Nourhashemi F" first="Fati" last="Nourhashemi">Fati Nourhashemi</name><affiliation wicri:level="1"><mods:affiliation>Gérontopôle, CMRR, Toulouse, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gérontopôle, CMRR, Toulouse</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Inserm U558, Toulouse, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm U558, Toulouse</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>University of Toulouse III, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Toulouse III</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: fatinour@orange.fr</mods:affiliation><country wicri:rule="url">France</country></affiliation></author><author><name sortKey="Andrieu, Sandrine" sort="Andrieu, Sandrine" uniqKey="Andrieu S" first="Sandrine" last="Andrieu">Sandrine Andrieu</name><affiliation wicri:level="1"><mods:affiliation>Gérontopôle, CMRR, Toulouse, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gérontopôle, CMRR, Toulouse</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Inserm U558, Toulouse, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm U558, Toulouse</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>University of Toulouse III, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Toulouse III</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Epidemiology and Public Health, Toulouse University Hospital, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology and Public Health, Toulouse University Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Gillette Guyonnet, Sophie" sort="Gillette Guyonnet, Sophie" uniqKey="Gillette Guyonnet S" first="Sophie" last="Gillette-Guyonnet">Sophie Gillette-Guyonnet</name><affiliation wicri:level="1"><mods:affiliation>Gérontopôle, CMRR, Toulouse, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gérontopôle, CMRR, Toulouse</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Inserm U558, Toulouse, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm U558, Toulouse</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>University of Toulouse III, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Toulouse III</wicri:regionArea></affiliation></author><author><name sortKey="Giraudeau, Bruno" sort="Giraudeau, Bruno" uniqKey="Giraudeau B" first="Bruno" last="Giraudeau">Bruno Giraudeau</name><affiliation wicri:level="1"><mods:affiliation>Inserm CIC-202, Tours, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm CIC-202, Tours</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>François Rabelais University, Tours, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>François Rabelais University, Tours</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>CHRU de Tours, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHRU de Tours</wicri:regionArea></affiliation></author><author><name sortKey="Cantet, Christelle" sort="Cantet, Christelle" uniqKey="Cantet C" first="Christelle" last="Cantet">Christelle Cantet</name><affiliation wicri:level="1"><mods:affiliation>Inserm U558, Toulouse, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm U558, Toulouse</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>University of Toulouse III, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Toulouse III</wicri:regionArea></affiliation></author><author><name sortKey="Coley, Nicola" sort="Coley, Nicola" uniqKey="Coley N" first="Nicola" last="Coley">Nicola Coley</name><affiliation wicri:level="1"><mods:affiliation>Inserm U558, Toulouse, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm U558, Toulouse</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>University of Toulouse III, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Toulouse III</wicri:regionArea></affiliation></author><author><name sortKey="Vellas, Bruno" sort="Vellas, Bruno" uniqKey="Vellas B" first="Bruno" last="Vellas">Bruno Vellas</name><affiliation wicri:level="1"><mods:affiliation>Gérontopôle, CMRR, Toulouse, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gérontopôle, CMRR, Toulouse</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Inserm U558, Toulouse, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm U558, Toulouse</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>University of Toulouse III, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Toulouse III</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">BMJ</title><title level="j" type="abbrev">BMJ</title><idno type="ISSN">0959-8138</idno><idno type="eISSN">1468-5833</idno><imprint><publisher>British Medical Journal Publishing Group</publisher><date type="published" when="2010">2010</date><biblScope unit="volume">340</biblScope></imprint><idno type="ISSN">0959-8138</idno></series><idno type="istex">FF52288570DE05AA74E2A5E7C8196C19258AD889</idno><idno type="DOI">10.1136/bmj.c2466</idno><idno type="href">bmj-340-bmj-c2466.pdf</idno><idno type="ArticleID">nouf740902</idno><idno type="PMID">20522656</idno><idno type="local">bmj;340/jun03_1/c2466</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0959-8138</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Objective To test the effectiveness of a comprehensive specific care plan in decreasing the rate of functional decline in patients with mild to moderate Alzheimer’s disease compared with usual care in memory clinics. Design Cluster randomised trial. Setting 50 memory clinics in France. Participants Patients with Alzheimer’s disease (mini-mental state examination score 12-26). 1131 patients were included: 574 from 26 clinics in the intervention group, and 557 from 24 clinics in the usual care (control) group. Memory clinics were the unit of randomisation. Intervention The intervention included a comprehensive standardised twice yearly consultation for patients and their caregivers, with standardised guidelines for the management of problems identified during the assessment. Main outcome measures The primary outcome measure was change on the Alzheimer’s Disease Cooperative Study-activities of daily living scale assessed at 12 and 24 months. Secondary outcome measures were the rate of admission to institutional care and mortality. Results At two years the assessment was completed by 58.4% (n=335) of patients in the intervention group and 61.6% (n=343) in the control group. The rate of functional decline at two years did not differ between the groups. The annual rate of change on the Alzheimer’s Disease Cooperative Study-activities of daily living was estimated at −5.73 (95% confidence interval −6.89 to −4.57) in the intervention group and −5.96 (−7.05 to −4.86) in the control group (P=0.78). Conclusion A comprehensive specific care plan in memory clinics had no additional positive effect on functional decline in patients with mild to moderate Alzheimer’s disease. Future research should aim to determine the effects of more direct involvement of general practitioners. Trial registration ClinicalTrials.gov NCT00480220.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/France/explor/LeHavreV1/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001183 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 001183 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/France
|area= LeHavreV1
|flux= Istex
|étape= Curation
|type= RBID
|clé= ISTEX:FF52288570DE05AA74E2A5E7C8196C19258AD889
|texte= Effectiveness of a specific care plan in patients with Alzheimer’s disease: cluster randomised trial (PLASA study)
}}
| This area was generated with Dilib version V0.6.25. |  |