Measurement of metformin concentration in erythrocytes:clinical implications
Identifieur interne : 000338 ( Istex/Curation ); précédent : 000337; suivant : 000339Measurement of metformin concentration in erythrocytes:clinical implications
Auteurs : J. Lalau [France] ; C. Lacroix [France]Source :
- Diabetes, Obesity and Metabolism [ 1462-8902 ] ; 2003-03.
English descriptors
Abstract
Aims: Although pharmacokinetics studies have long suggested a deep compartment for the antidiabetic drug metformin, there is still little information concerning metformin accumulation by individual tissues in man. In the present study, the erythrocyte was chosen to represent this putative deep compartment and metformin concentration in erythrocytes (EM) was compared with that in plasma (PM) to delineate clinical implications.
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DOI: 10.1046/j.1463-1326.2003.00241.x
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