Current aspects of the spectrum of acute heart failure syndromes in a real‐life setting: the OFICA study
Identifieur interne : 001834 ( Istex/Corpus ); précédent : 001833; suivant : 001835Current aspects of the spectrum of acute heart failure syndromes in a real‐life setting: the OFICA study
Auteurs : Damien Logeart ; Richard Isnard ; Matthieu Resche-Rigon ; Marie-France Seronde ; Pascal De Groote ; Guillaume Jondeau ; Michel Galinier ; Geneviève Mulak ; Erwan Donal ; François Delahaye ; Yves Juilliere ; Thibaud Damy ; Patrick Jourdain ; Fabrice Bauer ; Jean-Christophe Eicher ; Yannick Neuder ; Jean-Noël TrochuSource :
- European Journal of Heart Failure [ 1388-9842 ] ; 2013-04.
Abstract
To improve knowledge of epidemiological data, management, and clinical outcome of acute heart failure (AHF) in a real‐life setting in France.
Url:
DOI: 10.1093/eurjhf/hfs189
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ISTEX:D5912EF93B39A279EF3FBCC8A14901B141A9A6D4Le document en format XML
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Richard" uniqKey="Isnard R" first="Richard" last="Isnard">Richard Isnard</name><affiliation><mods:affiliation>AP‐HP, Groupe Hospitalier Pitie Salpetriere, Paris 6 University, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Resche Igon, Matthieu" sort="Resche Igon, Matthieu" uniqKey="Resche Igon M" first="Matthieu" last="Resche-Rigon">Matthieu Resche-Rigon</name><affiliation><mods:affiliation>AP‐HP, Groupe Hospitalier Lariboisiere Saint Louis, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Seronde, Marie Rance" sort="Seronde, Marie Rance" uniqKey="Seronde M" first="Marie-France" last="Seronde">Marie-France Seronde</name><affiliation><mods:affiliation>Centre Hospitalier Universitaire Minoz, Besançon, France</mods:affiliation></affiliation></author><author><name sortKey="De Groote, Pascal" sort="De Groote, Pascal" uniqKey="De Groote P" first="Pascal" last="De Groote">Pascal De Groote</name><affiliation><mods:affiliation>Centre Hospitalier Regional Universitaire de Lille, France</mods:affiliation></affiliation></author><author><name sortKey="Jondeau, Guillaume" sort="Jondeau, Guillaume" uniqKey="Jondeau G" first="Guillaume" last="Jondeau">Guillaume Jondeau</name><affiliation><mods:affiliation>AP‐HP, Groupe Hospitalier Bichat Claude Bernard, INSERM U698, Paris 7 University, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Galinier, Michel" sort="Galinier, Michel" uniqKey="Galinier M" first="Michel" last="Galinier">Michel Galinier</name><affiliation><mods:affiliation>Centre Hospitalier Universitaire Rangueil, Toulouse, France</mods:affiliation></affiliation></author><author><name sortKey="Mulak, Genevieve" sort="Mulak, Genevieve" uniqKey="Mulak G" first="Geneviève" last="Mulak">Geneviève Mulak</name><affiliation><mods:affiliation>French Society of Cardiology, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Donal, Erwan" sort="Donal, Erwan" 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France</mods:affiliation></affiliation></author><author><name sortKey="Jourdain, Patrick" sort="Jourdain, Patrick" uniqKey="Jourdain P" first="Patrick" last="Jourdain">Patrick Jourdain</name><affiliation><mods:affiliation>Centre Hospitalier Rene Dubosc, Pontoise, France</mods:affiliation></affiliation></author><author><name sortKey="Bauer, Fabrice" sort="Bauer, Fabrice" uniqKey="Bauer F" first="Fabrice" last="Bauer">Fabrice Bauer</name><affiliation><mods:affiliation>Hopital Charles Nicolle, Rouen, France</mods:affiliation></affiliation></author><author><name sortKey="Eicher, Jean Hristophe" sort="Eicher, Jean Hristophe" uniqKey="Eicher J" first="Jean-Christophe" last="Eicher">Jean-Christophe Eicher</name><affiliation><mods:affiliation>Centre Hospitalier Universitaire, Dijon, France</mods:affiliation></affiliation></author><author><name sortKey="Neuder, Yannick" sort="Neuder, Yannick" uniqKey="Neuder Y" first="Yannick" last="Neuder">Yannick Neuder</name><affiliation><mods:affiliation>Centre Hospitalier Universitaire, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Trochu, Jean Oel" sort="Trochu, Jean Oel" uniqKey="Trochu J" first="Jean-Noël" last="Trochu">Jean-Noël Trochu</name><affiliation><mods:affiliation>INSERM UMR1087, Université de Nantes, Centre Hospitalier Universitaire Nantes, Nantes, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Heart Failure</title><title level="j" type="abbrev">European Journal of Heart Failure</title><idno type="ISSN">1388-9842</idno><idno type="eISSN">1879-0844</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><date type="published" when="2013-04">2013-04</date><biblScope unit="volume">15</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="465">465</biblScope><biblScope unit="page" to="476">476</biblScope></imprint><idno 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France</json:string></affiliations></json:item><json:item><name>Matthieu Resche‐Rigon</name><affiliations><json:string>AP‐HP, Groupe Hospitalier Lariboisiere Saint Louis, Paris, France</json:string></affiliations></json:item><json:item><name>Marie‐France Seronde</name><affiliations><json:string>Centre Hospitalier Universitaire Minoz, Besançon, France</json:string></affiliations></json:item><json:item><name>Pascal de Groote</name><affiliations><json:string>Centre Hospitalier Regional Universitaire de Lille, France</json:string></affiliations></json:item><json:item><name>Guillaume Jondeau</name><affiliations><json:string>AP‐HP, Groupe Hospitalier Bichat Claude Bernard, INSERM U698, Paris 7 University, Paris, France</json:string></affiliations></json:item><json:item><name>Michel Galinier</name><affiliations><json:string>Centre Hospitalier Universitaire Rangueil, Toulouse, France</json:string></affiliations></json:item><json:item><name>Geneviève Mulak</name><affiliations><json:string>French Society of Cardiology, Paris, France</json:string></affiliations></json:item><json:item><name>Erwan Donal</name><affiliations><json:string>Centre Hospitalier Universitaire Pontchaillou, CIC‐IT 804, LTSI INSERM U1099, Rennes, France</json:string></affiliations></json:item><json:item><name>François Delahaye</name><affiliations><json:string>Hospices Civils de Lyon, Claude Bernard University, Lyon</json:string></affiliations></json:item><json:item><name>Yves Juilliere</name><affiliations><json:string>Centre Hospitalier Universitaire Brabois, Nancy, France</json:string></affiliations></json:item><json:item><name>Thibaud Damy</name><affiliations><json:string>AP‐HP, Hopital Henri Mondor, Créteil, France</json:string></affiliations></json:item><json:item><name>Patrick Jourdain</name><affiliations><json:string>Centre Hospitalier Rene Dubosc, Pontoise, France</json:string></affiliations></json:item><json:item><name>Fabrice Bauer</name><affiliations><json:string>Hopital Charles Nicolle, Rouen, France</json:string></affiliations></json:item><json:item><name>Jean‐Christophe Eicher</name><affiliations><json:string>Centre Hospitalier Universitaire, Dijon, France</json:string></affiliations></json:item><json:item><name>Yannick Neuder</name><affiliations><json:string>Centre Hospitalier Universitaire, Grenoble, France</json:string></affiliations></json:item><json:item><name>Jean‐Noël Trochu</name><affiliations><json:string>INSERM UMR1087, Université de Nantes, Centre Hospitalier Universitaire Nantes, Nantes, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Heart failure</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Health survey</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Therapeutics</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Guidelines</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Hospital mortality</value></json:item></subject><articleId><json:string>EJHFHFS189</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><qualityIndicators><score>6.252</score><pdfVersion>1.5</pdfVersion><pdfPageSize>595.276 x 793.701 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>141</abstractCharCount><pdfWordCount>6899</pdfWordCount><pdfCharCount>49496</pdfCharCount><pdfPageCount>12</pdfPageCount><abstractWordCount>21</abstractWordCount></qualityIndicators><title>Current aspects of the spectrum of acute heart failure syndromes in a real‐life setting: the OFICA study</title><corporate><json:item><name>on behalf of the working group on Heart Failure of the French Society of Cardiology</name></json:item></corporate><genre><json:string>article</json:string></genre><host><volume>15</volume><publisherId><json:string>EJHF</json:string></publisherId><pages><total>12</total><last>476</last><first>465</first></pages><issn><json:string>1388-9842</json:string></issn><issue>4</issue><subject><json:item><value>Trial</value></json:item></subject><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1879-0844</json:string></eissn><title>European Journal of Heart Failure</title><doi><json:string>10.1002/(ISSN)1879-0844</json:string></doi></host><publicationDate>2013</publicationDate><copyrightDate>2013</copyrightDate><doi><json:string>10.1093/eurjhf/hfs189</json:string></doi><id>D5912EF93B39A279EF3FBCC8A14901B141A9A6D4</id><score>0.094146445</score><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/D5912EF93B39A279EF3FBCC8A14901B141A9A6D4/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/D5912EF93B39A279EF3FBCC8A14901B141A9A6D4/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/D5912EF93B39A279EF3FBCC8A14901B141A9A6D4/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Current aspects of the spectrum of acute heart failure syndromes in a real‐life setting: the OFICA study</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><availability><p>© 2013 European Society of CardiologyPublished on behalf of the European Society of Cardiology. All rights reserved. © 2013 the Authors</p></availability><date>2013-11-26</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Current aspects of the spectrum of acute heart failure syndromes in a real‐life setting: the OFICA study</title><author><orgName>on behalf of the working group on Heart Failure of the French Society of Cardiology</orgName></author><author xml:id="author-1"><persName><forename type="first">Damien</forename><surname>Logeart</surname></persName><note type="correspondence"><p>Correspondence: Corresponding author: Hopital Lariboisiere, 2 Rue Ambroise Pare, 75010 Paris, France. Tel: +33 1 49956565, Fax: +33 1 49958439, Email:</p></note><affiliation>AP‐HP, Groupe Hospitalier Lariboisiere Saint Louis, INSERM U942, Paris 7 University, Paris, France</affiliation></author><author xml:id="author-2"><persName><forename type="first">Richard</forename><surname>Isnard</surname></persName><affiliation>AP‐HP, Groupe Hospitalier Pitie Salpetriere, Paris 6 University, Paris, France</affiliation></author><author xml:id="author-3"><persName><forename type="first">Matthieu</forename><surname>Resche‐Rigon</surname></persName><affiliation>AP‐HP, Groupe Hospitalier Lariboisiere Saint Louis, Paris, France</affiliation></author><author xml:id="author-4"><persName><forename type="first">Marie‐France</forename><surname>Seronde</surname></persName><affiliation>Centre Hospitalier Universitaire Minoz, Besançon, France</affiliation></author><author xml:id="author-5"><persName><forename type="first">Pascal</forename><surname>de Groote</surname></persName><affiliation>Centre Hospitalier Regional Universitaire de Lille, France</affiliation></author><author xml:id="author-6"><persName><forename type="first">Guillaume</forename><surname>Jondeau</surname></persName><affiliation>AP‐HP, Groupe Hospitalier Bichat Claude Bernard, INSERM U698, Paris 7 University, Paris, France</affiliation></author><author xml:id="author-7"><persName><forename type="first">Michel</forename><surname>Galinier</surname></persName><affiliation>Centre Hospitalier Universitaire Rangueil, Toulouse, France</affiliation></author><author xml:id="author-8"><persName><forename type="first">Geneviève</forename><surname>Mulak</surname></persName><affiliation>French Society of Cardiology, Paris, France</affiliation></author><author xml:id="author-9"><persName><forename type="first">Erwan</forename><surname>Donal</surname></persName><affiliation>Centre Hospitalier Universitaire Pontchaillou, CIC‐IT 804, LTSI INSERM U1099, Rennes, France</affiliation></author><author xml:id="author-10"><persName><forename type="first">François</forename><surname>Delahaye</surname></persName><affiliation>Hospices Civils de Lyon, Claude Bernard University, Lyon</affiliation></author><author xml:id="author-11"><persName><forename type="first">Yves</forename><surname>Juilliere</surname></persName><affiliation>Centre Hospitalier Universitaire Brabois, Nancy, France</affiliation></author><author xml:id="author-12"><persName><forename type="first">Thibaud</forename><surname>Damy</surname></persName><affiliation>AP‐HP, Hopital Henri Mondor, Créteil, France</affiliation></author><author xml:id="author-13"><persName><forename type="first">Patrick</forename><surname>Jourdain</surname></persName><affiliation>Centre Hospitalier Rene Dubosc, Pontoise, France</affiliation></author><author xml:id="author-14"><persName><forename type="first">Fabrice</forename><surname>Bauer</surname></persName><affiliation>Hopital Charles Nicolle, Rouen, France</affiliation></author><author xml:id="author-15"><persName><forename type="first">Jean‐Christophe</forename><surname>Eicher</surname></persName><affiliation>Centre Hospitalier Universitaire, Dijon, France</affiliation></author><author xml:id="author-16"><persName><forename type="first">Yannick</forename><surname>Neuder</surname></persName><affiliation>Centre Hospitalier Universitaire, Grenoble, France</affiliation></author><author xml:id="author-17"><persName><forename type="first">Jean‐Noël</forename><surname>Trochu</surname></persName><affiliation>INSERM UMR1087, Université de Nantes, Centre Hospitalier Universitaire Nantes, Nantes, France</affiliation></author></analytic><monogr><title level="j">European Journal of Heart Failure</title><title level="j" type="abbrev">European Journal of Heart Failure</title><idno type="pISSN">1388-9842</idno><idno type="eISSN">1879-0844</idno><idno type="DOI">10.1002/(ISSN)1879-0844</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><date type="published" when="2013-04"></date><biblScope unit="volume">15</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="465">465</biblScope><biblScope unit="page" to="476">476</biblScope></imprint></monogr><idno type="istex">D5912EF93B39A279EF3FBCC8A14901B141A9A6D4</idno><idno type="DOI">10.1093/eurjhf/hfs189</idno><idno type="ArticleID">EJHFHFS189</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2013-11-26</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>To improve knowledge of epidemiological data, management, and clinical outcome of acute heart failure (AHF) in a real‐life setting in France.</p></abstract><abstract><p>We conducted an observational survey constituting a single‐day snapshot of all unplanned hospitalizations because of AHF in 170 hospitals throughout France (the OFICA survey). A total of 1658 patients (median age 79 years, 55% male) were included. Family doctors were the first medical contact in 43% of cases, and patients were admitted through emergency departments in 64% of cases. Clinical scenarios were mainly acutely decompensated HF (48%) and acute pulmonary oedema (38%) with similar clinical and biological characteristics as well as outcome. Characteristics were different and severity higher in both shock and right HF. Infection and arrhythmia were the most frequent precipitating factors (27% and 24% of cases); diabetes and chronic pulmonary disease were the most frequent co‐morbidities (31% and 21%). Over 80% of patients underwent both natriuretic peptide testing and echocardiography. LVEF was preserved (>50%) in 36% of patients and associated with specific characteristics and lower severity. Median hospital stay was 13 days; in‐hospital mortality was 8.2%, and independent predictors were age, blood pressure, and creatinine. Treatment at discharge in patients with reduced LVEF included ACE inhibitors/ARBs, beta‐blockers, and aldosterone inhibitors in 78, 67, and 27% cases. Non‐surgical devices were reported in <20% of potential candidates.</p></abstract><abstract><p>This comprehensive survey analysing AHF in real life emphasizes the heterogeneous nature and overall high severity of AHF. It could be a useful tool to identify unsolved medical issues and improve outcome. Trial registration: NCT01080937</p></abstract><textClass><keywords scheme="keyword"><list><head>keywords</head><item><term>Heart failure</term></item><item><term>Health survey</term></item><item><term>Therapeutics</term></item><item><term>Guidelines</term></item><item><term>Hospital mortality</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Trial</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2012-07-19">Received</change><change when="2012-09-07">Registration</change><change when="2013-11-26">Created</change><change when="2013-04">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/D5912EF93B39A279EF3FBCC8A14901B141A9A6D4/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en" xml:id="EJHFHFS189"><header><publicationMeta level="product"><doi origin="wiley">10.1002/(ISSN)1879-0844</doi><issn type="print">1388-9842</issn><issn type="electronic">1879-0844</issn><idGroup><id type="product" value="EJHF"></id></idGroup><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="7"></count><count type="referenceTotal" number="37"></count></countGroup><titleGroup><title type="main" sort="EUROPEAN JOURNAL OF HEART FAILURE">European Journal of Heart Failure</title><title type="short">European Journal of Heart Failure</title></titleGroup></publicationMeta><publicationMeta level="part" position="40"><doi origin="wiley">10.1002/ejhf.2013.15.issue-4</doi><copyright ownership="publisher">© 2013 European Society of Cardiology</copyright><numberingGroup><numbering type="journalVolume" number="15">15</numbering><numbering type="journalIssue">4</numbering></numberingGroup><coverDate startDate="2013-04">April 2013</coverDate></publicationMeta><publicationMeta level="unit" position="150" type="article" status="forIssue"><doi origin="wiley">10.1093/eurjhf/hfs189</doi><idGroup><id type="unit" value="EJHFHFS189"></id></idGroup><countGroup><count type="pageTotal" number="12"></count></countGroup><titleGroup><title type="articleCategory">Trial</title><title type="tocHeading1">Trials</title></titleGroup><copyright ownership="thirdParty">Published on behalf of the European Society of Cardiology. All rights reserved. © 2013 the Authors</copyright><eventGroup><event type="manuscriptReceived" date="2012-07-19"></event><event type="manuscriptRevised" date="2012-09-05"></event><event type="manuscriptAccepted" date="2012-09-07"></event><event type="xmlCreated" agent="Aptara" date="2013-11-26"></event><event type="publishedOnlineFinalForm" date="2014-01-27"></event><event type="firstOnline" date="2014-01-27"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-02"></event></eventGroup><numberingGroup><numbering type="pageFirst">465</numbering><numbering type="pageLast">476</numbering></numberingGroup><correspondenceTo>Corresponding author: Hopital Lariboisiere, 2 Rue Ambroise Pare, 75010 Paris, France. Tel: +33 1 49956565, Fax: +33 1 49958439, Email: <email>damien.logeart@lrb.aphp.fr</email></correspondenceTo><objectNameGroup><objectName elementName="appendix">Appendix. Participating investigators</objectName></objectNameGroup><linkGroup><link type="toTypesetVersion" href="file://EJHF.EJHFHFS189.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Current aspects of the spectrum of acute heart failure syndromes in a real‐life setting: the OFICA study</title></titleGroup><creators><creator xml:id="ejhfhfs189-cr-0001" creatorRole="author" affiliationRef="#ejhfhfs189-aff-0001" corresponding="yes"><personName><familyName>Logeart</familyName><givenNames>Damien</givenNames></personName></creator><creator xml:id="ejhfhfs189-cr-0002" creatorRole="author" affiliationRef="#ejhfhfs189-aff-0002" corresponding="no"><personName><familyName>Isnard</familyName><givenNames>Richard</givenNames></personName></creator><creator xml:id="ejhfhfs189-cr-0003" creatorRole="author" affiliationRef="#ejhfhfs189-aff-0003" corresponding="no"><personName><familyName>Resche‐Rigon</familyName><givenNames>Matthieu</givenNames></personName></creator><creator xml:id="ejhfhfs189-cr-0004" creatorRole="author" affiliationRef="#ejhfhfs189-aff-0004" corresponding="no"><personName><familyName>Seronde</familyName><givenNames>Marie‐France</givenNames></personName></creator><creator xml:id="ejhfhfs189-cr-0005" creatorRole="author" affiliationRef="#ejhfhfs189-aff-0005" corresponding="no"><personName><familyNamePrefix>de</familyNamePrefix><familyName>Groote</familyName><givenNames>Pascal</givenNames></personName></creator><creator xml:id="ejhfhfs189-cr-0006" creatorRole="author" affiliationRef="#ejhfhfs189-aff-0006" corresponding="no"><personName><familyName>Jondeau</familyName><givenNames>Guillaume</givenNames></personName></creator><creator xml:id="ejhfhfs189-cr-0007" creatorRole="author" affiliationRef="#ejhfhfs189-aff-0007" corresponding="no"><personName><familyName>Galinier</familyName><givenNames>Michel</givenNames></personName></creator><creator xml:id="ejhfhfs189-cr-0008" creatorRole="author" affiliationRef="#ejhfhfs189-aff-0008" corresponding="no"><personName><familyName>Mulak</familyName><givenNames>Geneviève</givenNames></personName></creator><creator xml:id="ejhfhfs189-cr-0009" creatorRole="author" affiliationRef="#ejhfhfs189-aff-0009" corresponding="no"><personName><familyName>Donal</familyName><givenNames>Erwan</givenNames></personName></creator><creator xml:id="ejhfhfs189-cr-0010" creatorRole="author" affiliationRef="#ejhfhfs189-aff-0010" corresponding="no"><personName><familyName>Delahaye</familyName><givenNames>François</givenNames></personName></creator><creator xml:id="ejhfhfs189-cr-0011" creatorRole="author" affiliationRef="#ejhfhfs189-aff-0011" corresponding="no"><personName><familyName>Juilliere</familyName><givenNames>Yves</givenNames></personName></creator><creator xml:id="ejhfhfs189-cr-0012" creatorRole="author" affiliationRef="#ejhfhfs189-aff-0012" corresponding="no"><personName><familyName>Damy</familyName><givenNames>Thibaud</givenNames></personName></creator><creator xml:id="ejhfhfs189-cr-0013" creatorRole="author" affiliationRef="#ejhfhfs189-aff-0013" corresponding="no"><personName><familyName>Jourdain</familyName><givenNames>Patrick</givenNames></personName></creator><creator xml:id="ejhfhfs189-cr-0014" creatorRole="author" affiliationRef="#ejhfhfs189-aff-0014" corresponding="no"><personName><familyName>Bauer</familyName><givenNames>Fabrice</givenNames></personName></creator><creator xml:id="ejhfhfs189-cr-0015" creatorRole="author" affiliationRef="#ejhfhfs189-aff-0015" corresponding="no"><personName><familyName>Eicher</familyName><givenNames>Jean‐Christophe</givenNames></personName></creator><creator xml:id="ejhfhfs189-cr-0016" creatorRole="author" affiliationRef="#ejhfhfs189-aff-0016" corresponding="no"><personName><familyName>Neuder</familyName><givenNames>Yannick</givenNames></personName></creator><creator xml:id="ejhfhfs189-cr-0017" creatorRole="author" affiliationRef="#ejhfhfs189-aff-0017" corresponding="no"><personName><familyName>Trochu</familyName><givenNames>Jean‐Noël</givenNames></personName></creator><creator xml:id="ejhfhfs189-cr-0018" creatorRole="author" noteRef="#ejhfhfs189-note-0001"><groupName>on behalf of the working group on Heart Failure of the French Society of Cardiology</groupName></creator></creators><affiliationGroup><affiliation xml:id="ejhfhfs189-aff-0001" type="organization" countryCode="FR"><orgName>AP‐HP, Groupe Hospitalier Lariboisiere Saint Louis</orgName><address><street>INSERM U942</street><countryPart>Paris 7 University</countryPart><city>Paris</city><country>France</country></address></affiliation><affiliation xml:id="ejhfhfs189-aff-0002" type="organization" countryCode="FR"><orgName>AP‐HP, Groupe Hospitalier Pitie Salpetriere</orgName><address><countryPart>Paris 6 University</countryPart><city>Paris</city><country>France</country></address></affiliation><affiliation xml:id="ejhfhfs189-aff-0003" type="organization" countryCode="FR"><orgName>AP‐HP, Groupe Hospitalier Lariboisiere Saint Louis</orgName><address><city>Paris</city><country>France</country></address></affiliation><affiliation xml:id="ejhfhfs189-aff-0004" type="organization" countryCode="FR"><orgName>Centre Hospitalier Universitaire Minoz</orgName><address><city>Besançon</city><country>France</country></address></affiliation><affiliation xml:id="ejhfhfs189-aff-0005" type="organization" countryCode="FR"><orgName>Centre Hospitalier Regional Universitaire de Lille</orgName><address><country>France</country></address></affiliation><affiliation xml:id="ejhfhfs189-aff-0006" type="organization" countryCode="FR"><orgName>AP‐HP, Groupe Hospitalier Bichat Claude Bernard</orgName><address><street>INSERM U698</street><countryPart>Paris 7 University</countryPart><city>Paris</city><country>France</country></address></affiliation><affiliation xml:id="ejhfhfs189-aff-0007" type="organization" countryCode="FR"><orgName>Centre Hospitalier Universitaire Rangueil</orgName><address><city>Toulouse</city><country>France</country></address></affiliation><affiliation xml:id="ejhfhfs189-aff-0008" type="organization" countryCode="FR"><orgName>French Society of Cardiology</orgName><address><city>Paris</city><country>France</country></address></affiliation><affiliation xml:id="ejhfhfs189-aff-0009" type="organization" countryCode="FR"><orgName>Centre Hospitalier Universitaire Pontchaillou</orgName><address><street>CIC‐IT 804, LTSI INSERM U1099</street><city>Rennes</city><country>France</country></address></affiliation><affiliation xml:id="ejhfhfs189-aff-0010" type="organization" countryCode="FR"><orgDiv>Hospices Civils de Lyon</orgDiv><orgName>Claude Bernard University</orgName><address><city>Lyon</city></address></affiliation><affiliation xml:id="ejhfhfs189-aff-0011" type="organization" countryCode="FR"><orgName>Centre Hospitalier Universitaire Brabois</orgName><address><city>Nancy</city><country>France</country></address></affiliation><affiliation xml:id="ejhfhfs189-aff-0012" type="organization" countryCode="FR"><orgName>AP‐HP, Hopital Henri Mondor</orgName><address><city>Créteil</city><country>France</country></address></affiliation><affiliation xml:id="ejhfhfs189-aff-0013" type="organization" countryCode="FR"><orgName>Centre Hospitalier Rene Dubosc</orgName><address><city>Pontoise</city><country>France</country></address></affiliation><affiliation xml:id="ejhfhfs189-aff-0014" type="organization" countryCode="FR"><orgName>Hopital Charles Nicolle</orgName><address><city>Rouen</city><country>France</country></address></affiliation><affiliation xml:id="ejhfhfs189-aff-0015" type="organization" countryCode="FR"><orgName>Centre Hospitalier Universitaire</orgName><address><city>Dijon</city><country>France</country></address></affiliation><affiliation xml:id="ejhfhfs189-aff-0016" type="organization" countryCode="FR"><orgName>Centre Hospitalier Universitaire</orgName><address><city>Grenoble</city><country>France</country></address></affiliation><affiliation xml:id="ejhfhfs189-aff-0017" type="organization" countryCode="FR"><orgName>INSERM UMR1087, Université de Nantes, Centre Hospitalier Universitaire Nantes</orgName><address><city>Nantes</city><country>France</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="ejhfhfs189-kwd-0001">Heart failure</keyword><keyword xml:id="ejhfhfs189-kwd-0002">Health survey</keyword><keyword xml:id="ejhfhfs189-kwd-0003">Therapeutics</keyword><keyword xml:id="ejhfhfs189-kwd-0004">Guidelines</keyword><keyword xml:id="ejhfhfs189-kwd-0005">Hospital mortality</keyword></keywordGroup><abstractGroup><abstract type="main"><section xml:id="ejhfhfs189-sec-0001"><title type="main">Aims</title><p>To improve knowledge of epidemiological data, management, and clinical outcome of acute heart failure (AHF) in a real‐life setting in France.</p></section><section xml:id="ejhfhfs189-sec-0002"><title type="main">Methods and results</title><p>We conducted an observational survey constituting a single‐day snapshot of all unplanned hospitalizations because of AHF in 170 hospitals throughout France (the OFICA survey). A total of 1658 patients (median age 79 years, 55% male) were included. Family doctors were the first medical contact in 43% of cases, and patients were admitted through emergency departments in 64% of cases. Clinical scenarios were mainly acutely decompensated HF (48%) and acute pulmonary oedema (38%) with similar clinical and biological characteristics as well as outcome. Characteristics were different and severity higher in both shock and right HF. Infection and arrhythmia were the most frequent precipitating factors (27% and 24% of cases); diabetes and chronic pulmonary disease were the most frequent co‐morbidities (31% and 21%). Over 80% of patients underwent both natriuretic peptide testing and echocardiography. LVEF was preserved (>50%) in 36% of patients and associated with specific characteristics and lower severity. Median hospital stay was 13 days; in‐hospital mortality was 8.2%, and independent predictors were age, blood pressure, and creatinine. Treatment at discharge in patients with reduced LVEF included ACE inhibitors/ARBs, beta‐blockers, and aldosterone inhibitors in 78, 67, and 27% cases. Non‐surgical devices were reported in <20% of potential candidates.</p></section><section xml:id="ejhfhfs189-sec-0003"><title type="main">Conclusion</title><p>This comprehensive survey analysing AHF in real life emphasizes the heterogeneous nature and overall high severity of AHF. It could be a useful tool to identify unsolved medical issues and improve outcome.</p><p><b>Trial registration</b>: NCT01080937</p></section></abstract></abstractGroup></contentMeta><noteGroup xml:id="ejhfhfs189-ntgp-0001"><note xml:id="ejhfhfs189-note-0001"><label>†</label>A complete list of participating investigators is given in the Appendix.</note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Current aspects of the spectrum of acute heart failure syndromes in a real‐life setting: the OFICA study</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Current aspects of the spectrum of acute heart failure syndromes in a real‐life setting: the OFICA study</title></titleInfo><name type="personal"><namePart type="given">Damien</namePart><namePart type="family">Logeart</namePart><affiliation>AP‐HP, Groupe Hospitalier Lariboisiere Saint Louis, INSERM U942, Paris 7 University, Paris, France</affiliation><description>Correspondence: Corresponding author: Hopital Lariboisiere, 2 Rue Ambroise Pare, 75010 Paris, France. Tel: +33 1 49956565, Fax: +33 1 49958439, Email: </description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Richard</namePart><namePart type="family">Isnard</namePart><affiliation>AP‐HP, Groupe Hospitalier Pitie Salpetriere, Paris 6 University, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Matthieu</namePart><namePart type="family">Resche‐Rigon</namePart><affiliation>AP‐HP, Groupe Hospitalier Lariboisiere Saint Louis, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marie‐France</namePart><namePart type="family">Seronde</namePart><affiliation>Centre Hospitalier Universitaire Minoz, Besançon, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pascal</namePart><namePart type="family">de Groote</namePart><affiliation>Centre Hospitalier Regional Universitaire de Lille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Guillaume</namePart><namePart type="family">Jondeau</namePart><affiliation>AP‐HP, Groupe Hospitalier Bichat Claude Bernard, INSERM U698, Paris 7 University, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michel</namePart><namePart type="family">Galinier</namePart><affiliation>Centre Hospitalier Universitaire Rangueil, Toulouse, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Geneviève</namePart><namePart type="family">Mulak</namePart><affiliation>French Society of Cardiology, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Erwan</namePart><namePart type="family">Donal</namePart><affiliation>Centre Hospitalier Universitaire Pontchaillou, CIC‐IT 804, LTSI INSERM U1099, Rennes, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">François</namePart><namePart type="family">Delahaye</namePart><affiliation>Hospices Civils de Lyon, Claude Bernard University, Lyon</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yves</namePart><namePart type="family">Juilliere</namePart><affiliation>Centre Hospitalier Universitaire Brabois, Nancy, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Thibaud</namePart><namePart type="family">Damy</namePart><affiliation>AP‐HP, Hopital Henri Mondor, Créteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Patrick</namePart><namePart type="family">Jourdain</namePart><affiliation>Centre Hospitalier Rene Dubosc, Pontoise, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Fabrice</namePart><namePart type="family">Bauer</namePart><affiliation>Hopital Charles Nicolle, Rouen, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean‐Christophe</namePart><namePart type="family">Eicher</namePart><affiliation>Centre Hospitalier Universitaire, Dijon, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yannick</namePart><namePart type="family">Neuder</namePart><affiliation>Centre Hospitalier Universitaire, Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean‐Noël</namePart><namePart type="family">Trochu</namePart><affiliation>INSERM UMR1087, Université de Nantes, Centre Hospitalier Universitaire Nantes, Nantes, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="corporate"><namePart>on behalf of the working group on Heart Failure of the French Society of Cardiology</namePart></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2013-04</dateIssued><dateCreated encoding="w3cdtf">2013-11-26</dateCreated><dateCaptured encoding="w3cdtf">2012-07-19</dateCaptured><dateValid encoding="w3cdtf">2012-09-07</dateValid><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>To improve knowledge of epidemiological data, management, and clinical outcome of acute heart failure (AHF) in a real‐life setting in France.</abstract><abstract>We conducted an observational survey constituting a single‐day snapshot of all unplanned hospitalizations because of AHF in 170 hospitals throughout France (the OFICA survey). A total of 1658 patients (median age 79 years, 55% male) were included. Family doctors were the first medical contact in 43% of cases, and patients were admitted through emergency departments in 64% of cases. Clinical scenarios were mainly acutely decompensated HF (48%) and acute pulmonary oedema (38%) with similar clinical and biological characteristics as well as outcome. Characteristics were different and severity higher in both shock and right HF. Infection and arrhythmia were the most frequent precipitating factors (27% and 24% of cases); diabetes and chronic pulmonary disease were the most frequent co‐morbidities (31% and 21%). Over 80% of patients underwent both natriuretic peptide testing and echocardiography. LVEF was preserved (>50%) in 36% of patients and associated with specific characteristics and lower severity. Median hospital stay was 13 days; in‐hospital mortality was 8.2%, and independent predictors were age, blood pressure, and creatinine. Treatment at discharge in patients with reduced LVEF included ACE inhibitors/ARBs, beta‐blockers, and aldosterone inhibitors in 78, 67, and 27% cases. Non‐surgical devices were reported in <20% of potential candidates.</abstract><abstract>This comprehensive survey analysing AHF in real life emphasizes the heterogeneous nature and overall high severity of AHF. It could be a useful tool to identify unsolved medical issues and improve outcome. Trial registration: NCT01080937</abstract><subject><genre>keywords</genre><topic>Heart failure</topic><topic>Health survey</topic><topic>Therapeutics</topic><topic>Guidelines</topic><topic>Hospital mortality</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Heart Failure</title></titleInfo><titleInfo type="abbreviated"><title>European Journal of Heart Failure</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Trial</topic></subject><identifier type="ISSN">1388-9842</identifier><identifier type="eISSN">1879-0844</identifier><identifier type="DOI">10.1002/(ISSN)1879-0844</identifier><identifier type="PublisherID">EJHF</identifier><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>465</start><end>476</end><total>12</total></extent></part></relatedItem><identifier type="istex">D5912EF93B39A279EF3FBCC8A14901B141A9A6D4</identifier><identifier type="DOI">10.1093/eurjhf/hfs189</identifier><identifier type="ArticleID">EJHFHFS189</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2013 European Society of CardiologyPublished on behalf of the European Society of Cardiology. 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