Work-related asthma in France: recent trends for the period 2001–2009
Identifieur interne : 001773 ( Istex/Corpus ); précédent : 001772; suivant : 001774Work-related asthma in France: recent trends for the period 2001–2009
Auteurs : Christophe Paris ; Joseph Ngatchou-Wandji ; Amandine Luc ; Roseanne Mcnamee ; Lynda Bensefa-Colas ; Lynda Larabi ; Maylis Telle-Lamberton ; Fabrice Herin ; Alain Bergeret ; Vincent Bonneterre ; Patrick Brochard ; Dominique Choudat ; Dominique Dupas ; Robert Garnier ; Jean-Claude Pairon ; Raymond M. Agius ; Jacques AmeilleSource :
- Occupational and Environmental Medicine [ 1351-0711 ] ; 2012-06.
Abstract
Objective Knowledge on the time-course (trends) of work-related asthma (WRA) remains sparse. The aim of this study was to describe WRA trends in terms of industrial activities and the main causal agents in France over the period 2001–2009. Method Data were collected from the French national network of occupational health surveillance and prevention (Réseau National de Vigilance et de Prévention des Pathologies Professionnelles (RNV3P)). Several statistical models (non-parametric test, zero-inflated negative binomial, logistic regression and time-series models) were used and compared with assess trends. Results Over the study period, 2914 WRA cases were included in the network. A significant decrease was observed overall and for some agents such as isocyanates (p=0.007), aldehydes (p=0.01) and latex (p=0.01). Conversely, a significant increase was observed for cases related to exposure to quaternary ammonium compounds (p=0.003). The health and social sector demonstrated both a growing number of cases related to the use of quaternary ammonium compounds and a decrease of cases related to aldehyde and latex exposure. Conclusions WRA declined in France over the study period. The only significant increase concerned WRA related to exposure to quaternary ammonium compounds. Zero-inflated negative binomial and logistic regression models appear to describe adequately these data.
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DOI: 10.1136/oemed-2011-100487
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sortKey="Dupas, Dominique" sort="Dupas, Dominique" uniqKey="Dupas D" first="Dominique" last="Dupas">Dominique Dupas</name><affiliation><mods:affiliation>Occupational Health Department, University Hospital, Nantes, France</mods:affiliation></affiliation></author><author><name sortKey="Garnier, Robert" sort="Garnier, Robert" uniqKey="Garnier R" first="Robert" last="Garnier">Robert Garnier</name><affiliation><mods:affiliation>Occupational Health Department, APHP, Denis Diderot University, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Pairon, Jean Claude" sort="Pairon, Jean Claude" uniqKey="Pairon J" first="Jean-Claude" last="Pairon">Jean-Claude Pairon</name><affiliation><mods:affiliation>Inserm U 955, Occupational Health Department, University Hospital, Créteil, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Occupational Diseases Department, University Hospital, Creteil, France</mods:affiliation></affiliation></author><author><name 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Agius</name><affiliation><mods:affiliation>School of Community Based Medicine, The University of Manchester, Manchester, UK</mods:affiliation></affiliation></author><author><name sortKey="Ameille, Jacques" sort="Ameille, Jacques" uniqKey="Ameille J" first="Jacques" last="Ameille">Jacques Ameille</name><affiliation><mods:affiliation>Occupational Health Department, AP-HP, Garches, France</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:86D44239551B0256F253FB01EB007F6F6EB662A5</idno><date when="2012" year="2012">2012</date><idno type="doi">10.1136/oemed-2011-100487</idno><idno type="url">https://api.istex.fr/document/86D44239551B0256F253FB01EB007F6F6EB662A5/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001773</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Work-related asthma in France: recent trends for the period 2001–2009</title><author><name sortKey="Paris, Christophe" sort="Paris, Christophe" uniqKey="Paris C" first="Christophe" last="Paris">Christophe Paris</name><affiliation><mods:affiliation>Inserm U954, Vandoeuvre Les Nancy, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Occupational Diseases Department, University Hospital, Nancy, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence to Professor Christophe Paris, Inserm Research Unit U954, 9 rue de la Foret de Haye, Vandoeuvre Les Nancy 54505, France; christophe.paris@nancy.inserm.fr</mods:affiliation></affiliation></author><author><name sortKey="Ngatchou Wandji, Joseph" sort="Ngatchou Wandji, Joseph" uniqKey="Ngatchou Wandji J" first="Joseph" last="Ngatchou-Wandji">Joseph Ngatchou-Wandji</name><affiliation><mods:affiliation>Inserm U954, Vandoeuvre Les Nancy, France</mods:affiliation></affiliation></author><author><name sortKey="Luc, Amandine" sort="Luc, Amandine" uniqKey="Luc A" first="Amandine" last="Luc">Amandine Luc</name><affiliation><mods:affiliation>Inserm U954, Vandoeuvre Les Nancy, France</mods:affiliation></affiliation></author><author><name sortKey="Mcnamee, Roseanne" sort="Mcnamee, Roseanne" uniqKey="Mcnamee R" first="Roseanne" last="Mcnamee">Roseanne Mcnamee</name><affiliation><mods:affiliation>School of Community Based Medicine, The University of Manchester, Manchester, UK</mods:affiliation></affiliation></author><author><name sortKey="Bensefa Colas, Lynda" sort="Bensefa Colas, Lynda" uniqKey="Bensefa Colas L" first="Lynda" last="Bensefa-Colas">Lynda Bensefa-Colas</name><affiliation><mods:affiliation>Occupational Health Department, Paris Descartes University, Sorbonne Paris Cité, AP-HP, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Larabi, Lynda" sort="Larabi, Lynda" uniqKey="Larabi L" first="Lynda" last="Larabi">Lynda Larabi</name><affiliation><mods:affiliation>Occupational Health Department, University Hospital, Public Health Sector, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Telle Lamberton, Maylis" sort="Telle Lamberton, Maylis" uniqKey="Telle Lamberton M" first="Maylis" last="Telle-Lamberton">Maylis Telle-Lamberton</name><affiliation><mods:affiliation>Agence Nationale de Sécurité Sanitaire (ANSES), Maisons-Alfort, USA</mods:affiliation></affiliation></author><author><name sortKey="Herin, Fabrice" sort="Herin, Fabrice" uniqKey="Herin F" first="Fabrice" last="Herin">Fabrice Herin</name><affiliation><mods:affiliation>Occupational Diseases Department, University Hospital, Nancy, France</mods:affiliation></affiliation></author><author><name sortKey="Bergeret, Alain" sort="Bergeret, Alain" uniqKey="Bergeret A" first="Alain" last="Bergeret">Alain Bergeret</name><affiliation><mods:affiliation>Occupational Health Department, University Hospital, Lyon, France</mods:affiliation></affiliation></author><author><name sortKey="Bonneterre, Vincent" sort="Bonneterre, Vincent" uniqKey="Bonneterre V" first="Vincent" last="Bonneterre">Vincent Bonneterre</name><affiliation><mods:affiliation>UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Brochard, Patrick" sort="Brochard, Patrick" uniqKey="Brochard P" first="Patrick" last="Brochard">Patrick Brochard</name><affiliation><mods:affiliation>Occupational Health Department, University Hospital, Bordeaux, France</mods:affiliation></affiliation></author><author><name sortKey="Choudat, Dominique" sort="Choudat, Dominique" uniqKey="Choudat D" first="Dominique" last="Choudat">Dominique Choudat</name><affiliation><mods:affiliation>Occupational Health Department, Paris Descartes University, Sorbonne Paris Cité, AP-HP, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Dupas, Dominique" sort="Dupas, Dominique" uniqKey="Dupas D" first="Dominique" last="Dupas">Dominique Dupas</name><affiliation><mods:affiliation>Occupational Health Department, University Hospital, Nantes, France</mods:affiliation></affiliation></author><author><name sortKey="Garnier, Robert" sort="Garnier, Robert" uniqKey="Garnier R" first="Robert" last="Garnier">Robert Garnier</name><affiliation><mods:affiliation>Occupational Health Department, APHP, Denis Diderot University, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Pairon, Jean Claude" sort="Pairon, Jean Claude" uniqKey="Pairon J" first="Jean-Claude" last="Pairon">Jean-Claude Pairon</name><affiliation><mods:affiliation>Inserm U 955, Occupational Health Department, University Hospital, Créteil, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Occupational Diseases Department, University Hospital, Creteil, France</mods:affiliation></affiliation></author><author><name sortKey="Agius, Raymond M" sort="Agius, Raymond M" uniqKey="Agius R" first="Raymond M" last="Agius">Raymond M. Agius</name><affiliation><mods:affiliation>School of Community Based Medicine, The University of Manchester, Manchester, UK</mods:affiliation></affiliation></author><author><name sortKey="Ameille, Jacques" sort="Ameille, Jacques" uniqKey="Ameille J" first="Jacques" last="Ameille">Jacques Ameille</name><affiliation><mods:affiliation>Occupational Health Department, AP-HP, Garches, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Occupational and Environmental Medicine</title><title level="j" type="abbrev">Occup Environ Med</title><idno type="ISSN">1351-0711</idno><idno type="eISSN">1470-7926</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2012-06">2012-06</date><biblScope unit="volume">69</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="391">391</biblScope></imprint><idno type="ISSN">1351-0711</idno></series><idno type="istex">86D44239551B0256F253FB01EB007F6F6EB662A5</idno><idno type="DOI">10.1136/oemed-2011-100487</idno><idno type="href">oemed-69-391.pdf</idno><idno type="ArticleID">oemed-2011-100487</idno><idno type="PMID">22383588</idno><idno type="local">oemed;69/6/391</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-0711</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Objective Knowledge on the time-course (trends) of work-related asthma (WRA) remains sparse. The aim of this study was to describe WRA trends in terms of industrial activities and the main causal agents in France over the period 2001–2009. Method Data were collected from the French national network of occupational health surveillance and prevention (Réseau National de Vigilance et de Prévention des Pathologies Professionnelles (RNV3P)). Several statistical models (non-parametric test, zero-inflated negative binomial, logistic regression and time-series models) were used and compared with assess trends. Results Over the study period, 2914 WRA cases were included in the network. A significant decrease was observed overall and for some agents such as isocyanates (p=0.007), aldehydes (p=0.01) and latex (p=0.01). Conversely, a significant increase was observed for cases related to exposure to quaternary ammonium compounds (p=0.003). The health and social sector demonstrated both a growing number of cases related to the use of quaternary ammonium compounds and a decrease of cases related to aldehyde and latex exposure. Conclusions WRA declined in France over the study period. The only significant increase concerned WRA related to exposure to quaternary ammonium compounds. Zero-inflated negative binomial and logistic regression models appear to describe adequately these data.</div></front></TEI><istex><corpusName>bmj</corpusName><author><json:item><name>Christophe Paris</name><affiliations><json:string>Inserm U954, Vandoeuvre Les Nancy, France</json:string><json:string>Occupational Diseases Department, University Hospital, Nancy, France</json:string><json:string>Correspondence to Professor Christophe Paris, Inserm Research Unit U954, 9 rue de la Foret de Haye, Vandoeuvre Les Nancy 54505, France; christophe.paris@nancy.inserm.fr</json:string></affiliations></json:item><json:item><name>Joseph Ngatchou-Wandji</name><affiliations><json:string>Inserm U954, Vandoeuvre Les Nancy, France</json:string></affiliations></json:item><json:item><name>Amandine Luc</name><affiliations><json:string>Inserm U954, Vandoeuvre Les Nancy, France</json:string></affiliations></json:item><json:item><name>Roseanne McNamee</name><affiliations><json:string>School of Community Based Medicine, The University of Manchester, Manchester, UK</json:string></affiliations></json:item><json:item><name>Lynda Bensefa-Colas</name><affiliations><json:string>Occupational Health Department, Paris Descartes University, Sorbonne Paris Cité, AP-HP, Paris, France</json:string></affiliations></json:item><json:item><name>Lynda Larabi</name><affiliations><json:string>Occupational Health Department, University Hospital, Public Health Sector, Grenoble, France</json:string></affiliations></json:item><json:item><name>Maylis Telle-Lamberton</name><affiliations><json:string>Agence Nationale de Sécurité Sanitaire (ANSES), Maisons-Alfort, USA</json:string></affiliations></json:item><json:item><name>Fabrice Herin</name><affiliations><json:string>Occupational Diseases Department, University Hospital, Nancy, France</json:string></affiliations></json:item><json:item><name>Alain Bergeret</name><affiliations><json:string>Occupational Health Department, University Hospital, Lyon, France</json:string></affiliations></json:item><json:item><name>Vincent Bonneterre</name><affiliations><json:string>UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525, Grenoble, France</json:string></affiliations></json:item><json:item><name>Patrick Brochard</name><affiliations><json:string>Occupational Health Department, University Hospital, Bordeaux, France</json:string></affiliations></json:item><json:item><name>Dominique Choudat</name><affiliations><json:string>Occupational Health Department, Paris Descartes University, Sorbonne Paris Cité, AP-HP, Paris, France</json:string></affiliations></json:item><json:item><name>Dominique Dupas</name><affiliations><json:string>Occupational Health Department, University Hospital, Nantes, France</json:string></affiliations></json:item><json:item><name>Robert Garnier</name><affiliations><json:string>Occupational Health Department, APHP, Denis Diderot University, Paris, France</json:string></affiliations></json:item><json:item><name>Jean-Claude Pairon</name><affiliations><json:string>Inserm U 955, Occupational Health Department, University Hospital, Créteil, France</json:string><json:string>Occupational Diseases Department, University Hospital, Creteil, France</json:string></affiliations></json:item><json:item><name>Raymond M Agius</name><affiliations><json:string>School of Community Based Medicine, The University of Manchester, Manchester, UK</json:string></affiliations></json:item><json:item><name>Jacques Ameille</name><affiliations><json:string>Occupational Health Department, AP-HP, Garches, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Asthma</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>occupational exposure</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>statistical models</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>trend</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>work-related asthma</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>epidemiology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>occupational asthma</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cancer</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>retrospective exposure assessment</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>respiratory</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cardiovascular</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>statistics</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>mortality studies</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>mathematical models</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>legal</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>occupational health practice</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>musculoskeletal</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>back disorders</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>preventive medicine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>mineralogy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>lung function</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>exposure assessment</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cross-sectional studies</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>man-made mineral fibers</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>asbestos</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>silicosis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>pneumoconioses</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>mesothelioma</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>allergy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>OH services</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>male reproduction</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>health surveillance</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>clinical medicine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>biological monitoring</value></json:item></subject><articleId><json:string>oemed-2011-100487</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>research-article</json:string></originalGenre><abstract>Objective Knowledge on the time-course (trends) of work-related asthma (WRA) remains sparse. The aim of this study was to describe WRA trends in terms of industrial activities and the main causal agents in France over the period 2001–2009. Method Data were collected from the French national network of occupational health surveillance and prevention (Réseau National de Vigilance et de Prévention des Pathologies Professionnelles (RNV3P)). Several statistical models (non-parametric test, zero-inflated negative binomial, logistic regression and time-series models) were used and compared with assess trends. Results Over the study period, 2914 WRA cases were included in the network. A significant decrease was observed overall and for some agents such as isocyanates (p=0.007), aldehydes (p=0.01) and latex (p=0.01). Conversely, a significant increase was observed for cases related to exposure to quaternary ammonium compounds (p=0.003). The health and social sector demonstrated both a growing number of cases related to the use of quaternary ammonium compounds and a decrease of cases related to aldehyde and latex exposure. Conclusions WRA declined in France over the study period. The only significant increase concerned WRA related to exposure to quaternary ammonium compounds. Zero-inflated negative binomial and logistic regression models appear to describe adequately these data.</abstract><qualityIndicators><score>7.832</score><pdfVersion>1.4</pdfVersion><pdfPageSize>595.276 x 793.701 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>34</keywordCount><abstractCharCount>1391</abstractCharCount><pdfWordCount>4956</pdfWordCount><pdfCharCount>36057</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>198</abstractWordCount></qualityIndicators><title>Work-related asthma in France: recent trends for the period 2001–2009</title><pmid><json:string>22383588</json:string></pmid><corporate><json:item><name>the members of the RNV3P</name></json:item></corporate><genre><json:string>research-article</json:string></genre><host><volume>69</volume><publisherId><json:string>oem</json:string></publisherId><pages><first>391</first></pages><issn><json:string>1351-0711</json:string></issn><issue>6</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1470-7926</json:string></eissn><title>Occupational and Environmental Medicine</title></host><publicationDate>2012</publicationDate><copyrightDate>2012</copyrightDate><doi><json:string>10.1136/oemed-2011-100487</json:string></doi><id>86D44239551B0256F253FB01EB007F6F6EB662A5</id><score>0.10675237</score><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/86D44239551B0256F253FB01EB007F6F6EB662A5/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/86D44239551B0256F253FB01EB007F6F6EB662A5/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/86D44239551B0256F253FB01EB007F6F6EB662A5/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Work-related asthma in France: recent trends for the period 2001–2009</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>BMJ Publishing Group Ltd</publisher><availability><p>© 2012, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</p></availability><date>2012-03-01</date></publicationStmt><notesStmt><note>RNV3P members: Angers (Roquelaure Y., Petit A.), Amiens (Doutrellot-Philippon C.), Bobigny-Avicenne (Guillon F.), Besançon (Aptel M., Thiebaut A.), Bordeaux (Rinaldo M., Verdun-Esquer C.), Brest (Dewitte J.D., Lodde B.), Caen (Clin B., Marquignon M.F.), Cherbourg (Marquignon M.F.), Clermont-Ferrand (Chamoux A., Dutheil F.), Créteil (Pairon J.C., Andujar P.), Dijon (Smolik H.J.), Garches (Ameille J., d'Escatha A.), Grenoble (de Gaudemaris R., Bonneterre V.), Le Havre (Gislard A., Rollin L.), Lille (Frimat P., Nisse C.), Limoges (Druet-Cabanac M.), Lyon (Bergeret A., Normand J.C.), Marseille (Lehucher-Michel M.P.), Montpellier (Roulet A.), Nancy (Paris C., Penven E.), Nantes (Géraut C., Dupas D.), Paris-Cochin (Choudat D., Bensefa-Colas L.), Paris-Hôtel-Dieu (Léger D., Prevost Balensi E.), Paris-Fernand Widal (Garnier R., Villa A.), Poitiers (Ben-Brik E., Berson C.), Reims (Deschamps F., Lesage F.X.), Rennes (Verger C., Gouyet Ahu T.), Rouen (Gehanno J.F.), Saint-Etienne (Fontana L., Pélissier C.), Strasbourg (Cantineau A., Nourry N.), Toulouse (Soulat J.M., Hérin F.), Tours (Lasfargues G., Haguenoer K.).</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Work-related asthma in France: recent trends for the period 2001–2009</title><author><orgName>the members of the RNV3P</orgName></author><author xml:id="author-2"><persName><forename type="first">Christophe</forename><surname>Paris</surname></persName><affiliation>Inserm U954, Vandoeuvre Les Nancy, France</affiliation><affiliation>Occupational Diseases Department, University Hospital, Nancy, France</affiliation><affiliation>Correspondence to Professor Christophe Paris, Inserm Research Unit U954, 9 rue de la Foret de Haye, Vandoeuvre Les Nancy 54505, France; christophe.paris@nancy.inserm.fr</affiliation></author><author xml:id="author-3"><persName><forename type="first">Joseph</forename><surname>Ngatchou-Wandji</surname></persName><affiliation>Inserm U954, Vandoeuvre Les Nancy, France</affiliation></author><author xml:id="author-4"><persName><forename type="first">Amandine</forename><surname>Luc</surname></persName><affiliation>Inserm U954, Vandoeuvre Les Nancy, France</affiliation></author><author xml:id="author-5"><persName><forename type="first">Roseanne</forename><surname>McNamee</surname></persName><affiliation>School of Community Based Medicine, The University of Manchester, Manchester, UK</affiliation></author><author xml:id="author-6"><persName><forename type="first">Lynda</forename><surname>Bensefa-Colas</surname></persName><affiliation>Occupational Health Department, Paris Descartes University, Sorbonne Paris Cité, AP-HP, Paris, France</affiliation></author><author xml:id="author-7"><persName><forename type="first">Lynda</forename><surname>Larabi</surname></persName><affiliation>Occupational Health Department, University Hospital, Public Health Sector, Grenoble, France</affiliation></author><author xml:id="author-8"><persName><forename type="first">Maylis</forename><surname>Telle-Lamberton</surname></persName><affiliation>Agence Nationale de Sécurité Sanitaire (ANSES), Maisons-Alfort, USA</affiliation></author><author xml:id="author-9"><persName><forename type="first">Fabrice</forename><surname>Herin</surname></persName><affiliation>Occupational Diseases Department, University Hospital, Nancy, France</affiliation></author><author xml:id="author-10"><persName><forename type="first">Alain</forename><surname>Bergeret</surname></persName><affiliation>Occupational Health Department, University Hospital, Lyon, France</affiliation></author><author xml:id="author-11"><persName><forename type="first">Vincent</forename><surname>Bonneterre</surname></persName><affiliation>UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525, Grenoble, France</affiliation></author><author xml:id="author-12"><persName><forename type="first">Patrick</forename><surname>Brochard</surname></persName><affiliation>Occupational Health Department, University Hospital, Bordeaux, France</affiliation></author><author xml:id="author-13"><persName><forename type="first">Dominique</forename><surname>Choudat</surname></persName><affiliation>Occupational Health Department, Paris Descartes University, Sorbonne Paris Cité, AP-HP, Paris, France</affiliation></author><author xml:id="author-14"><persName><forename type="first">Dominique</forename><surname>Dupas</surname></persName><affiliation>Occupational Health Department, University Hospital, Nantes, France</affiliation></author><author xml:id="author-15"><persName><forename type="first">Robert</forename><surname>Garnier</surname></persName><affiliation>Occupational Health Department, APHP, Denis Diderot University, Paris, France</affiliation></author><author xml:id="author-16"><persName><forename type="first">Jean-Claude</forename><surname>Pairon</surname></persName><affiliation>Inserm U 955, Occupational Health Department, University Hospital, Créteil, France</affiliation><affiliation>Occupational Diseases Department, University Hospital, Creteil, France</affiliation></author><author xml:id="author-17"><persName><forename type="first">Raymond M</forename><surname>Agius</surname></persName><affiliation>School of Community Based Medicine, The University of Manchester, Manchester, UK</affiliation></author><author xml:id="author-18"><persName><forename type="first">Jacques</forename><surname>Ameille</surname></persName><affiliation>Occupational Health Department, AP-HP, Garches, France</affiliation></author></analytic><monogr><title level="j">Occupational and Environmental Medicine</title><title level="j" type="abbrev">Occup Environ Med</title><idno type="pISSN">1351-0711</idno><idno type="eISSN">1470-7926</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2012-06"></date><biblScope unit="volume">69</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="391">391</biblScope></imprint></monogr><idno type="istex">86D44239551B0256F253FB01EB007F6F6EB662A5</idno><idno type="DOI">10.1136/oemed-2011-100487</idno><idno type="href">oemed-69-391.pdf</idno><idno type="ArticleID">oemed-2011-100487</idno><idno type="PMID">22383588</idno><idno type="local">oemed;69/6/391</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2012-03-01</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Objective Knowledge on the time-course (trends) of work-related asthma (WRA) remains sparse. The aim of this study was to describe WRA trends in terms of industrial activities and the main causal agents in France over the period 2001–2009. Method Data were collected from the French national network of occupational health surveillance and prevention (Réseau National de Vigilance et de Prévention des Pathologies Professionnelles (RNV3P)). Several statistical models (non-parametric test, zero-inflated negative binomial, logistic regression and time-series models) were used and compared with assess trends. Results Over the study period, 2914 WRA cases were included in the network. A significant decrease was observed overall and for some agents such as isocyanates (p=0.007), aldehydes (p=0.01) and latex (p=0.01). Conversely, a significant increase was observed for cases related to exposure to quaternary ammonium compounds (p=0.003). The health and social sector demonstrated both a growing number of cases related to the use of quaternary ammonium compounds and a decrease of cases related to aldehyde and latex exposure. Conclusions WRA declined in France over the study period. The only significant increase concerned WRA related to exposure to quaternary ammonium compounds. Zero-inflated negative binomial and logistic regression models appear to describe adequately these data.</p></abstract><textClass><keywords scheme="keyword"><list><head>keywords</head><item><term>Asthma</term></item><item><term>occupational exposure</term></item><item><term>statistical models</term></item><item><term>trend</term></item><item><term>work-related asthma</term></item><item><term>epidemiology</term></item><item><term>occupational asthma</term></item><item><term>cancer</term></item><item><term>retrospective exposure assessment</term></item><item><term>respiratory</term></item><item><term>cardiovascular</term></item><item><term>statistics</term></item><item><term>mortality studies</term></item><item><term>mathematical models</term></item><item><term>legal</term></item><item><term>occupational health practice</term></item><item><term>musculoskeletal</term></item><item><term>back disorders</term></item><item><term>preventive medicine</term></item><item><term>mineralogy</term></item><item><term>lung function</term></item><item><term>exposure assessment</term></item><item><term>cross-sectional studies</term></item><item><term>man-made mineral fibers</term></item><item><term>asbestos</term></item><item><term>silicosis</term></item><item><term>pneumoconioses</term></item><item><term>mesothelioma</term></item><item><term>allergy</term></item><item><term>OH services</term></item><item><term>male reproduction</term></item><item><term>health surveillance</term></item><item><term>clinical medicine</term></item><item><term>biological monitoring</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2012-03-01">Created</change><change when="2012-06">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/86D44239551B0256F253FB01EB007F6F6EB662A5/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus bmj" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="no"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Archiving and Interchange DTD v2.3 20070202//EN" URI="archivearticle.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article"><front><journal-meta><journal-id journal-id-type="hwp">oemed</journal-id><journal-id journal-id-type="nlm-ta">Occup Environ Med</journal-id><journal-id journal-id-type="publisher-id">oem</journal-id><journal-title>Occupational and Environmental Medicine</journal-title><abbrev-journal-title abbrev-type="publisher">Occup Environ Med</abbrev-journal-title><abbrev-journal-title>Occup Environ Med</abbrev-journal-title><issn pub-type="ppub">1351-0711</issn><issn pub-type="epub">1470-7926</issn><publisher><publisher-name>BMJ Publishing Group Ltd</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">oemed-2011-100487</article-id><article-id pub-id-type="doi">10.1136/oemed-2011-100487</article-id><article-id pub-id-type="other">oemed;69/6/391</article-id><article-id pub-id-type="other">oemed;oemed-2011-100487</article-id><article-id pub-id-type="pmid">22383588</article-id><article-id pub-id-type="other">391</article-id><article-id pub-id-type="other">oemed-2011-100487</article-id><article-categories><subj-group subj-group-type="heading"><subject>Workplace</subject></subj-group><series-title>Original article</series-title></article-categories><title-group><article-title>Work-related asthma in France: recent trends for the period 2001–2009</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Paris</surname><given-names>Christophe</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Ngatchou-Wandji</surname><given-names>Joseph</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Luc</surname><given-names>Amandine</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>McNamee</surname><given-names>Roseanne</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Bensefa-Colas</surname><given-names>Lynda</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Larabi</surname><given-names>Lynda</given-names></name><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Telle-Lamberton</surname><given-names>Maylis</given-names></name><xref ref-type="aff" rid="aff6">6</xref></contrib><contrib contrib-type="author"><name><surname>Herin</surname><given-names>Fabrice</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Bergeret</surname><given-names>Alain</given-names></name><xref ref-type="aff" rid="aff7">7</xref></contrib><contrib contrib-type="author"><name><surname>Bonneterre</surname><given-names>Vincent</given-names></name><xref ref-type="aff" rid="aff8">8</xref></contrib><contrib contrib-type="author"><name><surname>Brochard</surname><given-names>Patrick</given-names></name><xref ref-type="aff" rid="aff9">9</xref></contrib><contrib contrib-type="author"><name><surname>Choudat</surname><given-names>Dominique</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Dupas</surname><given-names>Dominique</given-names></name><xref ref-type="aff" rid="aff10">10</xref></contrib><contrib contrib-type="author"><name><surname>Garnier</surname><given-names>Robert</given-names></name><xref ref-type="aff" rid="aff11">11</xref></contrib><contrib contrib-type="author"><name><surname>Pairon</surname><given-names>Jean-Claude</given-names></name><xref ref-type="aff" rid="aff12">12</xref><xref ref-type="aff" rid="aff13">13</xref></contrib><contrib contrib-type="author"><name><surname>Agius</surname><given-names>Raymond M</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Ameille</surname><given-names>Jacques</given-names></name><xref ref-type="aff" rid="aff14">14</xref></contrib><contrib contrib-type="author"><collab>the members of the RNV3P</collab></contrib></contrib-group><aff id="aff1"><label>1</label>Inserm U954, Vandoeuvre Les Nancy, France</aff><aff id="aff2"><label>2</label>Occupational Diseases Department, University Hospital, Nancy, France</aff><aff id="aff3"><label>3</label>School of Community Based Medicine, The University of Manchester, Manchester, UK</aff><aff id="aff4"><label>4</label>Occupational Health Department, Paris Descartes University, Sorbonne Paris Cité, AP-HP, Paris, France</aff><aff id="aff5"><label>5</label>Occupational Health Department, University Hospital, Public Health Sector, Grenoble, France</aff><aff id="aff6"><label>6</label>Agence Nationale de Sécurité Sanitaire (ANSES), Maisons-Alfort, USA</aff><aff id="aff7"><label>7</label>Occupational Health Department, University Hospital, Lyon, France</aff><aff id="aff8"><label>8</label>UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525, Grenoble, France</aff><aff id="aff9"><label>9</label>Occupational Health Department, University Hospital, Bordeaux, France</aff><aff id="aff10"><label>10</label>Occupational Health Department, University Hospital, Nantes, France</aff><aff id="aff11"><label>11</label>Occupational Health Department, APHP, Denis Diderot University, Paris, France</aff><aff id="aff12"><label>12</label>Inserm U 955, Occupational Health Department, University Hospital, Créteil, France</aff><aff id="aff13"><label>13</label>Occupational Diseases Department, University Hospital, Creteil, France</aff><aff id="aff14"><label>14</label>Occupational Health Department, AP-HP, Garches, France</aff><author-notes><corresp><label>Correspondence to</label> Professor Christophe Paris, Inserm Research Unit U954, 9 rue de la Foret de Haye, Vandoeuvre Les Nancy 54505, France; <email>christophe.paris@nancy.inserm.fr</email></corresp><fn fn-type="other"><p>RNV3P members: Angers (Roquelaure Y., Petit A.), Amiens (Doutrellot-Philippon C.), Bobigny-Avicenne (Guillon F.), Besançon (Aptel M., Thiebaut A.), Bordeaux (Rinaldo M., Verdun-Esquer C.), Brest (Dewitte J.D., Lodde B.), Caen (Clin B., Marquignon M.F.), Cherbourg (Marquignon M.F.), Clermont-Ferrand (Chamoux A., Dutheil F.), Créteil (Pairon J.C., Andujar P.), Dijon (Smolik H.J.), Garches (Ameille J., d'Escatha A.), Grenoble (de Gaudemaris R., Bonneterre V.), Le Havre (Gislard A., Rollin L.), Lille (Frimat P., Nisse C.), Limoges (Druet-Cabanac M.), Lyon (Bergeret A., Normand J.C.), Marseille (Lehucher-Michel M.P.), Montpellier (Roulet A.), Nancy (Paris C., Penven E.), Nantes (Géraut C., Dupas D.), Paris-Cochin (Choudat D., Bensefa-Colas L.), Paris-Hôtel-Dieu (Léger D., Prevost Balensi E.), Paris-Fernand Widal (Garnier R., Villa A.), Poitiers (Ben-Brik E., Berson C.), Reims (Deschamps F., Lesage F.X.), Rennes (Verger C., Gouyet Ahu T.), Rouen (Gehanno J.F.), Saint-Etienne (Fontana L., Pélissier C.), Strasbourg (Cantineau A., Nourry N.), Toulouse (Soulat J.M., Hérin F.), Tours (Lasfargues G., Haguenoer K.).</p></fn></author-notes><pub-date pub-type="epub-original"><day>1</day><month>3</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>6</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>1</day><month>3</month><year>2012</year></pub-date><volume>69</volume><volume-id pub-id-type="other">69</volume-id><volume-id pub-id-type="other">69</volume-id><issue>6</issue><issue-id pub-id-type="other">oemed;69/6</issue-id><issue-id pub-id-type="other">6</issue-id><issue-id pub-id-type="other">69/6</issue-id><fpage>391</fpage><history><date date-type="accepted"><day>11</day><month>1</month><year>2012</year></date></history><permissions><copyright-statement>© 2012, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</copyright-statement><copyright-year>2012</copyright-year></permissions><self-uri content-type="pdf" xlink:role="full-text" xlink:href="oemed-69-391.pdf"></self-uri><abstract><sec><title>Objective</title><p>Knowledge on the time-course (trends) of work-related asthma (WRA) remains sparse. The aim of this study was to describe WRA trends in terms of industrial activities and the main causal agents in France over the period 2001–2009.</p></sec><sec><title>Method</title><p>Data were collected from the French national network of occupational health surveillance and prevention (<italic>Réseau National de Vigilance et de Prévention des Pathologies Professionnelles</italic> (RNV3P)). Several statistical models (non-parametric test, zero-inflated negative binomial, logistic regression and time-series models) were used and compared with assess trends.</p></sec><sec><title>Results</title><p>Over the study period, 2914 WRA cases were included in the network. A significant decrease was observed overall and for some agents such as isocyanates (p=0.007), aldehydes (p=0.01) and latex (p=0.01). Conversely, a significant increase was observed for cases related to exposure to quaternary ammonium compounds (p=0.003). The health and social sector demonstrated both a growing number of cases related to the use of quaternary ammonium compounds and a decrease of cases related to aldehyde and latex exposure.</p></sec><sec><title>Conclusions</title><p>WRA declined in France over the study period. The only significant increase concerned WRA related to exposure to quaternary ammonium compounds. Zero-inflated negative binomial and logistic regression models appear to describe adequately these data.</p></sec></abstract><kwd-group><kwd>Asthma</kwd><kwd>occupational exposure</kwd><kwd>statistical models</kwd><kwd>trend</kwd><kwd>work-related asthma</kwd><kwd>epidemiology</kwd><kwd>occupational asthma</kwd><kwd>cancer</kwd><kwd>retrospective exposure assessment</kwd><kwd>respiratory</kwd><kwd>cardiovascular</kwd><kwd>statistics</kwd><kwd>mortality studies</kwd><kwd>mathematical models</kwd><kwd>legal</kwd><kwd>occupational health practice</kwd><kwd>musculoskeletal</kwd><kwd>back disorders</kwd><kwd>preventive medicine</kwd><kwd>mineralogy</kwd><kwd>lung function</kwd><kwd>exposure assessment</kwd><kwd>cross-sectional studies</kwd><kwd>man-made mineral fibers</kwd><kwd>asbestos</kwd><kwd>silicosis</kwd><kwd>pneumoconioses</kwd><kwd>mesothelioma</kwd><kwd>allergy</kwd><kwd>OH services</kwd><kwd>male reproduction</kwd><kwd>health surveillance</kwd><kwd>clinical medicine</kwd><kwd>biological monitoring</kwd></kwd-group></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Work-related asthma in France: recent trends for the period 2001–2009</title><partName>Original article</partName></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Work-related asthma in France: recent trends for the period 2001–2009</title><partName>Original article</partName></titleInfo><name type="corporate"><namePart>the members of the RNV3P</namePart></name><name type="personal"><namePart type="given">Christophe</namePart><namePart type="family">Paris</namePart><affiliation>Inserm U954, Vandoeuvre Les Nancy, France</affiliation><affiliation>Occupational Diseases Department, University Hospital, Nancy, France</affiliation><affiliation>Correspondence to Professor Christophe Paris, Inserm Research Unit U954, 9 rue de la Foret de Haye, Vandoeuvre Les Nancy 54505, France; christophe.paris@nancy.inserm.fr</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Joseph</namePart><namePart type="family">Ngatchou-Wandji</namePart><affiliation>Inserm U954, Vandoeuvre Les Nancy, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Amandine</namePart><namePart type="family">Luc</namePart><affiliation>Inserm U954, Vandoeuvre Les Nancy, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roseanne</namePart><namePart type="family">McNamee</namePart><affiliation>School of Community Based Medicine, The University of Manchester, Manchester, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lynda</namePart><namePart type="family">Bensefa-Colas</namePart><affiliation>Occupational Health Department, Paris Descartes University, Sorbonne Paris Cité, AP-HP, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lynda</namePart><namePart type="family">Larabi</namePart><affiliation>Occupational Health Department, University Hospital, Public Health Sector, Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Maylis</namePart><namePart type="family">Telle-Lamberton</namePart><affiliation>Agence Nationale de Sécurité Sanitaire (ANSES), Maisons-Alfort, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Fabrice</namePart><namePart type="family">Herin</namePart><affiliation>Occupational Diseases Department, University Hospital, Nancy, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alain</namePart><namePart type="family">Bergeret</namePart><affiliation>Occupational Health Department, University Hospital, Lyon, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Vincent</namePart><namePart type="family">Bonneterre</namePart><affiliation>UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525, Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Patrick</namePart><namePart type="family">Brochard</namePart><affiliation>Occupational Health Department, University Hospital, Bordeaux, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dominique</namePart><namePart type="family">Choudat</namePart><affiliation>Occupational Health Department, Paris Descartes University, Sorbonne Paris Cité, AP-HP, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dominique</namePart><namePart type="family">Dupas</namePart><affiliation>Occupational Health Department, University Hospital, Nantes, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Robert</namePart><namePart type="family">Garnier</namePart><affiliation>Occupational Health Department, APHP, Denis Diderot University, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean-Claude</namePart><namePart type="family">Pairon</namePart><affiliation>Inserm U 955, Occupational Health Department, University Hospital, Créteil, France</affiliation><affiliation>Occupational Diseases Department, University Hospital, Creteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Raymond M</namePart><namePart type="family">Agius</namePart><affiliation>School of Community Based Medicine, The University of Manchester, Manchester, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jacques</namePart><namePart type="family">Ameille</namePart><affiliation>Occupational Health Department, AP-HP, Garches, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><originInfo><publisher>BMJ Publishing Group Ltd</publisher><dateIssued encoding="w3cdtf">2012-06</dateIssued><dateCreated encoding="w3cdtf">2012-03-01</dateCreated><copyrightDate encoding="w3cdtf">2012</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>Objective Knowledge on the time-course (trends) of work-related asthma (WRA) remains sparse. The aim of this study was to describe WRA trends in terms of industrial activities and the main causal agents in France over the period 2001–2009. Method Data were collected from the French national network of occupational health surveillance and prevention (Réseau National de Vigilance et de Prévention des Pathologies Professionnelles (RNV3P)). Several statistical models (non-parametric test, zero-inflated negative binomial, logistic regression and time-series models) were used and compared with assess trends. Results Over the study period, 2914 WRA cases were included in the network. A significant decrease was observed overall and for some agents such as isocyanates (p=0.007), aldehydes (p=0.01) and latex (p=0.01). Conversely, a significant increase was observed for cases related to exposure to quaternary ammonium compounds (p=0.003). The health and social sector demonstrated both a growing number of cases related to the use of quaternary ammonium compounds and a decrease of cases related to aldehyde and latex exposure. Conclusions WRA declined in France over the study period. The only significant increase concerned WRA related to exposure to quaternary ammonium compounds. Zero-inflated negative binomial and logistic regression models appear to describe adequately these data.</abstract><note type="footnotes">RNV3P members: Angers (Roquelaure Y., Petit A.), Amiens (Doutrellot-Philippon C.), Bobigny-Avicenne (Guillon F.), Besançon (Aptel M., Thiebaut A.), Bordeaux (Rinaldo M., Verdun-Esquer C.), Brest (Dewitte J.D., Lodde B.), Caen (Clin B., Marquignon M.F.), Cherbourg (Marquignon M.F.), Clermont-Ferrand (Chamoux A., Dutheil F.), Créteil (Pairon J.C., Andujar P.), Dijon (Smolik H.J.), Garches (Ameille J., d'Escatha A.), Grenoble (de Gaudemaris R., Bonneterre V.), Le Havre (Gislard A., Rollin L.), Lille (Frimat P., Nisse C.), Limoges (Druet-Cabanac M.), Lyon (Bergeret A., Normand J.C.), Marseille (Lehucher-Michel M.P.), Montpellier (Roulet A.), Nancy (Paris C., Penven E.), Nantes (Géraut C., Dupas D.), Paris-Cochin (Choudat D., Bensefa-Colas L.), Paris-Hôtel-Dieu (Léger D., Prevost Balensi E.), Paris-Fernand Widal (Garnier R., Villa A.), Poitiers (Ben-Brik E., Berson C.), Reims (Deschamps F., Lesage F.X.), Rennes (Verger C., Gouyet Ahu T.), Rouen (Gehanno J.F.), Saint-Etienne (Fontana L., Pélissier C.), Strasbourg (Cantineau A., Nourry N.), Toulouse (Soulat J.M., Hérin F.), Tours (Lasfargues G., Haguenoer K.).</note><subject><genre>keywords</genre><topic>Asthma</topic><topic>occupational exposure</topic><topic>statistical models</topic><topic>trend</topic><topic>work-related asthma</topic><topic>epidemiology</topic><topic>occupational asthma</topic><topic>cancer</topic><topic>retrospective exposure assessment</topic><topic>respiratory</topic><topic>cardiovascular</topic><topic>statistics</topic><topic>mortality studies</topic><topic>mathematical models</topic><topic>legal</topic><topic>occupational health practice</topic><topic>musculoskeletal</topic><topic>back disorders</topic><topic>preventive medicine</topic><topic>mineralogy</topic><topic>lung function</topic><topic>exposure assessment</topic><topic>cross-sectional studies</topic><topic>man-made mineral fibers</topic><topic>asbestos</topic><topic>silicosis</topic><topic>pneumoconioses</topic><topic>mesothelioma</topic><topic>allergy</topic><topic>OH services</topic><topic>male reproduction</topic><topic>health surveillance</topic><topic>clinical medicine</topic><topic>biological monitoring</topic></subject><relatedItem type="host"><titleInfo><title>Occupational and Environmental Medicine</title></titleInfo><titleInfo type="abbreviated"><title>Occup Environ Med</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">1351-0711</identifier><identifier type="eISSN">1470-7926</identifier><identifier type="PublisherID">oem</identifier><identifier type="PublisherID-hwp">oemed</identifier><identifier type="PublisherID-nlm-ta">Occup Environ Med</identifier><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>69</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>391</start></extent></part></relatedItem><identifier type="istex">86D44239551B0256F253FB01EB007F6F6EB662A5</identifier><identifier type="DOI">10.1136/oemed-2011-100487</identifier><identifier type="href">oemed-69-391.pdf</identifier><identifier type="ArticleID">oemed-2011-100487</identifier><identifier type="PMID">22383588</identifier><identifier type="local">oemed;69/6/391</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2012, Published by the BMJ Publishing Group Limited. 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