Occupational asthma and occupational rhinitis: the united airways disease model revisited
Identifieur interne : 001481 ( Istex/Corpus ); précédent : 001480; suivant : 001482Occupational asthma and occupational rhinitis: the united airways disease model revisited
Auteurs : Jacques Ameille ; Karine Hamelin ; Pascal Andujar ; Lynda Bensefa-Colas ; Vincent Bonneterre ; Dominique Dupas ; Robert Garnier ; Brice Alain Loddé ; Mickael Rinaldo ; Alexis Descatha ; Gérard Lasfargues ; Jean-Claude Pairon ; C. Doutrellot-Philippon ; I. Thaon ; P. Brochard ; C. Verdun-Esquer ; Jd Dewitte ; B. Lodde ; M. Letourneux ; B. Clin ; Mf Marquignon ; A. Chamoux ; D. Gabrillargues ; Jc Pairon ; P. Andujar ; J. Ameille ; A. Descatha ; R. De Gaudemaris ; V. Bonneterre ; A. Gislard ; N. Lepage ; C. Nisse ; A. Bergeret ; Jc Normand ; Mp Le Hucher-Michel ; A. Roulet ; C. Paris ; E. Penven ; D. Dupas ; D. Choudat ; L. Bensefa-Colas ; R. Garnier ; A. Villa ; E. Ben-Brik ; C. Berson ; F. Deschamps ; Fx Lesage ; Jf Gehanno ; L. Fontana ; C. Orset ; A. Cantineau ; S. Kleinogel ; Jm Soulat ; F. HérinSource :
- Occupational and Environmental Medicine [ 1351-0711 ] ; 2013-07.
Abstract
Objectives Whereas accumulating evidence indicates close associations between rhinitis and asthma, little is known about the relationships between occupational rhinitis (OR) and occupational asthma (OA). This study analyses the prevalence of OR associated with OA, globally and according to the various causal agents, and investigates the temporal relationships between these two conditions. Methods Data on incident cases of OA (2008–2010) were collected through the French national occupational disease surveillance and prevention network, using a standardised form including information on occupation, causal agents, presence of OR, and respective dates of occurrence of rhinitis and asthma. Results Among the 596 reported OA cases with latency period, 555 could be attributed to identified agents: high molecular weight (HMW) agents (n=174); low molecular weight (LMW) agents (n=381). Overall, OR was associated with OA in 324 (58.4%) cases. The frequency of association was significantly higher for HMW agents than for LMW agents (72.2% vs 51.5%, p<0.001). OR occurred before OA significantly more frequently for HMW agents than for LMW agents (p<0.01). Conclusions These results show that OR is frequently associated with OA, especially when HMW agents are involved. They are consistent with the hypothesis that OR, in conjunction with OA, is more likely to be caused by sensitisers that cause disease via IgE-mediated mechanisms and suggest that symptoms of OR should be taken into account in the medical surveillance of workers exposed to HMW agents.
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DOI: 10.1136/oemed-2012-101048
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Letourneux</name></author><author wicri:is="80%"><name sortKey="Clin, B" sort="Clin, B" uniqKey="Clin B" first="B" last="Clin">B. Clin</name></author><author wicri:is="80%"><name sortKey="Marquignon, Mf" sort="Marquignon, Mf" uniqKey="Marquignon M" first="Mf" last="Marquignon">Mf Marquignon</name></author><author wicri:is="80%"><name sortKey="Chamoux, A" sort="Chamoux, A" uniqKey="Chamoux A" first="A" last="Chamoux">A. Chamoux</name></author><author wicri:is="80%"><name sortKey="Gabrillargues, D" sort="Gabrillargues, D" uniqKey="Gabrillargues D" first="D" last="Gabrillargues">D. Gabrillargues</name></author><author wicri:is="80%"><name sortKey="Pairon, Jc" sort="Pairon, Jc" uniqKey="Pairon J" first="Jc" last="Pairon">Jc Pairon</name></author><author wicri:is="80%"><name sortKey="Andujar, P" sort="Andujar, P" uniqKey="Andujar P" first="P" last="Andujar">P. Andujar</name></author><author wicri:is="80%"><name sortKey="Ameille, J" sort="Ameille, J" uniqKey="Ameille J" first="J" last="Ameille">J. Ameille</name></author><author wicri:is="80%"><name sortKey="Descatha, A" sort="Descatha, A" uniqKey="Descatha A" first="A" last="Descatha">A. Descatha</name></author><author wicri:is="80%"><name sortKey="De Gaudemaris, R" sort="De Gaudemaris, R" uniqKey="De Gaudemaris R" first="R" last="De Gaudemaris">R. De Gaudemaris</name></author><author wicri:is="80%"><name sortKey="Bonneterre, V" sort="Bonneterre, V" uniqKey="Bonneterre V" first="V" last="Bonneterre">V. Bonneterre</name></author><author wicri:is="80%"><name sortKey="Gislard, A" sort="Gislard, A" uniqKey="Gislard A" first="A" last="Gislard">A. Gislard</name></author><author wicri:is="80%"><name sortKey="Lepage, N" sort="Lepage, N" uniqKey="Lepage N" first="N" last="Lepage">N. Lepage</name></author><author wicri:is="80%"><name sortKey="Nisse, C" sort="Nisse, C" uniqKey="Nisse C" first="C" last="Nisse">C. Nisse</name></author><author wicri:is="80%"><name sortKey="Bergeret, A" sort="Bergeret, A" uniqKey="Bergeret A" first="A" last="Bergeret">A. Bergeret</name></author><author wicri:is="80%"><name sortKey="Normand, Jc" sort="Normand, Jc" uniqKey="Normand J" first="Jc" last="Normand">Jc Normand</name></author><author wicri:is="80%"><name sortKey="Le Hucher Michel, Mp" sort="Le Hucher Michel, Mp" uniqKey="Le Hucher Michel M" first="Mp" last="Le Hucher-Michel">Mp Le Hucher-Michel</name></author><author wicri:is="80%"><name sortKey="Roulet, A" sort="Roulet, A" uniqKey="Roulet A" first="A" last="Roulet">A. Roulet</name></author><author wicri:is="80%"><name sortKey="Paris, C" sort="Paris, C" uniqKey="Paris C" first="C" last="Paris">C. Paris</name></author><author wicri:is="80%"><name sortKey="Penven, E" sort="Penven, E" uniqKey="Penven E" first="E" last="Penven">E. Penven</name></author><author wicri:is="80%"><name sortKey="Dupas, D" sort="Dupas, D" uniqKey="Dupas D" first="D" last="Dupas">D. Dupas</name></author><author wicri:is="80%"><name sortKey="Choudat, D" sort="Choudat, D" uniqKey="Choudat D" first="D" last="Choudat">D. Choudat</name></author><author wicri:is="80%"><name sortKey="Bensefa Colas, L" sort="Bensefa Colas, L" uniqKey="Bensefa Colas L" first="L" last="Bensefa-Colas">L. Bensefa-Colas</name></author><author wicri:is="80%"><name sortKey="Garnier, R" sort="Garnier, R" uniqKey="Garnier R" first="R" last="Garnier">R. Garnier</name></author><author wicri:is="80%"><name sortKey="Villa, A" sort="Villa, A" uniqKey="Villa A" first="A" last="Villa">A. Villa</name></author><author wicri:is="80%"><name sortKey="Ben Brik, E" sort="Ben Brik, E" uniqKey="Ben Brik E" first="E" last="Ben-Brik">E. Ben-Brik</name></author><author wicri:is="80%"><name sortKey="Berson, C" sort="Berson, C" uniqKey="Berson C" first="C" last="Berson">C. Berson</name></author><author wicri:is="80%"><name sortKey="Deschamps, F" sort="Deschamps, F" uniqKey="Deschamps F" first="F" last="Deschamps">F. Deschamps</name></author><author wicri:is="80%"><name sortKey="Lesage, Fx" sort="Lesage, Fx" uniqKey="Lesage F" first="Fx" last="Lesage">Fx Lesage</name></author><author wicri:is="80%"><name sortKey="Gehanno, Jf" sort="Gehanno, Jf" uniqKey="Gehanno J" first="Jf" last="Gehanno">Jf Gehanno</name></author><author wicri:is="80%"><name sortKey="Fontana, L" sort="Fontana, L" uniqKey="Fontana L" first="L" last="Fontana">L. Fontana</name></author><author wicri:is="80%"><name sortKey="Orset, C" sort="Orset, C" uniqKey="Orset C" first="C" last="Orset">C. Orset</name></author><author wicri:is="80%"><name sortKey="Cantineau, A" sort="Cantineau, A" uniqKey="Cantineau A" first="A" last="Cantineau">A. Cantineau</name></author><author wicri:is="80%"><name sortKey="Kleinogel, S" sort="Kleinogel, S" uniqKey="Kleinogel S" first="S" last="Kleinogel">S. Kleinogel</name></author><author wicri:is="80%"><name sortKey="Soulat, Jm" sort="Soulat, Jm" uniqKey="Soulat J" first="Jm" last="Soulat">Jm Soulat</name></author><author wicri:is="80%"><name sortKey="Herin, F" sort="Herin, F" uniqKey="Herin F" first="F" last="Hérin">F. Hérin</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:80479D9602CE9DA591597EB74B87644289B6D6B6</idno><date when="2013" year="2013">2013</date><idno type="doi">10.1136/oemed-2012-101048</idno><idno type="url">https://api.istex.fr/document/80479D9602CE9DA591597EB74B87644289B6D6B6/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001481</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Occupational asthma and occupational rhinitis: the united airways disease model revisited</title><author><name sortKey="Ameille, Jacques" sort="Ameille, Jacques" uniqKey="Ameille J" first="Jacques" last="Ameille">Jacques Ameille</name><affiliation><mods:affiliation>AP-HP, Occupational Health Department, Raymond Poincaré hospital, Garches, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Institut interuniversitaire de médecine du travail, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Hamelin, Karine" sort="Hamelin, Karine" uniqKey="Hamelin K" first="Karine" last="Hamelin">Karine Hamelin</name><affiliation><mods:affiliation>Institut interuniversitaire de médecine du travail, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Andujar, Pascal" sort="Andujar, Pascal" uniqKey="Andujar P" first="Pascal" last="Andujar">Pascal Andujar</name><affiliation><mods:affiliation>INSERM U 955, and Occupational Health Department, Créteil, France</mods:affiliation></affiliation></author><author><name sortKey="Bensefa Colas, Lynda" sort="Bensefa Colas, Lynda" uniqKey="Bensefa Colas L" first="Lynda" last="Bensefa-Colas">Lynda Bensefa-Colas</name><affiliation><mods:affiliation>AP-HP, Occupational Health Department, Cochin hospital, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Bonneterre, Vincent" sort="Bonneterre, Vincent" uniqKey="Bonneterre V" first="Vincent" last="Bonneterre">Vincent Bonneterre</name><affiliation><mods:affiliation>UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Dupas, Dominique" sort="Dupas, Dominique" uniqKey="Dupas D" first="Dominique" last="Dupas">Dominique Dupas</name><affiliation><mods:affiliation>Occupational Health Department, University Hospital, Nantes, France</mods:affiliation></affiliation></author><author><name sortKey="Garnier, Robert" sort="Garnier, Robert" uniqKey="Garnier R" first="Robert" last="Garnier">Robert Garnier</name><affiliation><mods:affiliation>AP-HP, Occupational Health Department, Fernand-Widal Hospital, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Lodde, Brice Alain" sort="Lodde, Brice Alain" uniqKey="Lodde B" first="Brice Alain" last="Loddé">Brice Alain Loddé</name><affiliation><mods:affiliation>Occupational Health Department, University Hospital, Brest, France</mods:affiliation></affiliation></author><author><name sortKey="Rinaldo, Mickael" sort="Rinaldo, Mickael" uniqKey="Rinaldo M" first="Mickael" last="Rinaldo">Mickael Rinaldo</name><affiliation><mods:affiliation>Occupational Health Department, University Hospital, Bordeaux, France</mods:affiliation></affiliation></author><author><name sortKey="Descatha, Alexis" sort="Descatha, Alexis" uniqKey="Descatha A" first="Alexis" last="Descatha">Alexis Descatha</name><affiliation><mods:affiliation>AP-HP, Occupational Health Department, Raymond Poincaré hospital, Garches, France</mods:affiliation></affiliation></author><author><name sortKey="Lasfargues, Gerard" sort="Lasfargues, Gerard" uniqKey="Lasfargues G" first="Gérard" last="Lasfargues">Gérard Lasfargues</name><affiliation><mods:affiliation>Agence nationale de sécurité sanitaire, Maisons-Alfort, France</mods:affiliation></affiliation></author><author><name sortKey="Pairon, Jean Claude" sort="Pairon, Jean Claude" uniqKey="Pairon J" first="Jean-Claude" last="Pairon">Jean-Claude Pairon</name><affiliation><mods:affiliation>INSERM U 955, and Occupational Health Department, Créteil, France</mods:affiliation></affiliation></author><author wicri:is="80%"><name sortKey="Doutrellot Philippon, C" sort="Doutrellot Philippon, C" uniqKey="Doutrellot Philippon C" first="C" last="Doutrellot-Philippon">C. Doutrellot-Philippon</name></author><author wicri:is="80%"><name sortKey="Thaon, I" sort="Thaon, I" uniqKey="Thaon I" first="I" last="Thaon">I. Thaon</name></author><author wicri:is="80%"><name sortKey="Brochard, P" sort="Brochard, P" uniqKey="Brochard P" first="P" last="Brochard">P. Brochard</name></author><author wicri:is="80%"><name sortKey="Verdun Esquer, C" sort="Verdun Esquer, C" uniqKey="Verdun Esquer C" first="C" last="Verdun-Esquer">C. Verdun-Esquer</name></author><author wicri:is="80%"><name sortKey="Dewitte, Jd" sort="Dewitte, Jd" uniqKey="Dewitte J" first="Jd" last="Dewitte">Jd Dewitte</name></author><author wicri:is="80%"><name sortKey="Lodde, B" sort="Lodde, B" uniqKey="Lodde B" first="B" last="Lodde">B. Lodde</name></author><author wicri:is="80%"><name sortKey="Letourneux, M" sort="Letourneux, M" uniqKey="Letourneux M" first="M" last="Letourneux">M. Letourneux</name></author><author wicri:is="80%"><name sortKey="Clin, B" sort="Clin, B" uniqKey="Clin B" first="B" last="Clin">B. Clin</name></author><author wicri:is="80%"><name sortKey="Marquignon, Mf" sort="Marquignon, Mf" uniqKey="Marquignon M" first="Mf" last="Marquignon">Mf Marquignon</name></author><author wicri:is="80%"><name sortKey="Chamoux, A" sort="Chamoux, A" uniqKey="Chamoux A" first="A" last="Chamoux">A. Chamoux</name></author><author wicri:is="80%"><name sortKey="Gabrillargues, D" sort="Gabrillargues, D" uniqKey="Gabrillargues D" first="D" last="Gabrillargues">D. Gabrillargues</name></author><author wicri:is="80%"><name sortKey="Pairon, Jc" sort="Pairon, Jc" uniqKey="Pairon J" first="Jc" last="Pairon">Jc Pairon</name></author><author wicri:is="80%"><name sortKey="Andujar, P" sort="Andujar, P" uniqKey="Andujar P" first="P" last="Andujar">P. Andujar</name></author><author wicri:is="80%"><name sortKey="Ameille, J" sort="Ameille, J" uniqKey="Ameille J" first="J" last="Ameille">J. Ameille</name></author><author wicri:is="80%"><name sortKey="Descatha, A" sort="Descatha, A" uniqKey="Descatha A" first="A" last="Descatha">A. Descatha</name></author><author wicri:is="80%"><name sortKey="De Gaudemaris, R" sort="De Gaudemaris, R" uniqKey="De Gaudemaris R" first="R" last="De Gaudemaris">R. De Gaudemaris</name></author><author wicri:is="80%"><name sortKey="Bonneterre, V" sort="Bonneterre, V" uniqKey="Bonneterre V" first="V" last="Bonneterre">V. Bonneterre</name></author><author wicri:is="80%"><name sortKey="Gislard, A" sort="Gislard, A" uniqKey="Gislard A" first="A" last="Gislard">A. Gislard</name></author><author wicri:is="80%"><name sortKey="Lepage, N" sort="Lepage, N" uniqKey="Lepage N" first="N" last="Lepage">N. Lepage</name></author><author wicri:is="80%"><name sortKey="Nisse, C" sort="Nisse, C" uniqKey="Nisse C" first="C" last="Nisse">C. Nisse</name></author><author wicri:is="80%"><name sortKey="Bergeret, A" sort="Bergeret, A" uniqKey="Bergeret A" first="A" last="Bergeret">A. Bergeret</name></author><author wicri:is="80%"><name sortKey="Normand, Jc" sort="Normand, Jc" uniqKey="Normand J" first="Jc" last="Normand">Jc Normand</name></author><author wicri:is="80%"><name sortKey="Le Hucher Michel, Mp" sort="Le Hucher Michel, Mp" uniqKey="Le Hucher Michel M" first="Mp" last="Le Hucher-Michel">Mp Le Hucher-Michel</name></author><author wicri:is="80%"><name sortKey="Roulet, A" sort="Roulet, A" uniqKey="Roulet A" first="A" last="Roulet">A. Roulet</name></author><author wicri:is="80%"><name sortKey="Paris, C" sort="Paris, C" uniqKey="Paris C" first="C" last="Paris">C. Paris</name></author><author wicri:is="80%"><name sortKey="Penven, E" sort="Penven, E" uniqKey="Penven E" first="E" last="Penven">E. Penven</name></author><author wicri:is="80%"><name sortKey="Dupas, D" sort="Dupas, D" uniqKey="Dupas D" first="D" last="Dupas">D. Dupas</name></author><author wicri:is="80%"><name sortKey="Choudat, D" sort="Choudat, D" uniqKey="Choudat D" first="D" last="Choudat">D. Choudat</name></author><author wicri:is="80%"><name sortKey="Bensefa Colas, L" sort="Bensefa Colas, L" uniqKey="Bensefa Colas L" first="L" last="Bensefa-Colas">L. Bensefa-Colas</name></author><author wicri:is="80%"><name sortKey="Garnier, R" sort="Garnier, R" uniqKey="Garnier R" first="R" last="Garnier">R. Garnier</name></author><author wicri:is="80%"><name sortKey="Villa, A" sort="Villa, A" uniqKey="Villa A" first="A" last="Villa">A. Villa</name></author><author wicri:is="80%"><name sortKey="Ben Brik, E" sort="Ben Brik, E" uniqKey="Ben Brik E" first="E" last="Ben-Brik">E. Ben-Brik</name></author><author wicri:is="80%"><name sortKey="Berson, C" sort="Berson, C" uniqKey="Berson C" first="C" last="Berson">C. Berson</name></author><author wicri:is="80%"><name sortKey="Deschamps, F" sort="Deschamps, F" uniqKey="Deschamps F" first="F" last="Deschamps">F. Deschamps</name></author><author wicri:is="80%"><name sortKey="Lesage, Fx" sort="Lesage, Fx" uniqKey="Lesage F" first="Fx" last="Lesage">Fx Lesage</name></author><author wicri:is="80%"><name sortKey="Gehanno, Jf" sort="Gehanno, Jf" uniqKey="Gehanno J" first="Jf" last="Gehanno">Jf Gehanno</name></author><author wicri:is="80%"><name sortKey="Fontana, L" sort="Fontana, L" uniqKey="Fontana L" first="L" last="Fontana">L. Fontana</name></author><author wicri:is="80%"><name sortKey="Orset, C" sort="Orset, C" uniqKey="Orset C" first="C" last="Orset">C. Orset</name></author><author wicri:is="80%"><name sortKey="Cantineau, A" sort="Cantineau, A" uniqKey="Cantineau A" first="A" last="Cantineau">A. Cantineau</name></author><author wicri:is="80%"><name sortKey="Kleinogel, S" sort="Kleinogel, S" uniqKey="Kleinogel S" first="S" last="Kleinogel">S. Kleinogel</name></author><author wicri:is="80%"><name sortKey="Soulat, Jm" sort="Soulat, Jm" uniqKey="Soulat J" first="Jm" last="Soulat">Jm Soulat</name></author><author wicri:is="80%"><name sortKey="Herin, F" sort="Herin, F" uniqKey="Herin F" first="F" last="Hérin">F. Hérin</name></author></analytic><monogr></monogr><series><title level="j">Occupational and Environmental Medicine</title><title level="j" type="abbrev">Occup Environ Med</title><idno type="ISSN">1351-0711</idno><idno type="eISSN">1470-7926</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2013-07">2013-07</date><biblScope unit="volume">70</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="471">471</biblScope></imprint><idno type="ISSN">1351-0711</idno></series><idno type="istex">80479D9602CE9DA591597EB74B87644289B6D6B6</idno><idno type="DOI">10.1136/oemed-2012-101048</idno><idno type="href">oemed-70-471.pdf</idno><idno type="ArticleID">oemed-2012-101048</idno><idno type="PMID">23390199</idno><idno type="local">oemed;70/7/471</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-0711</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Objectives Whereas accumulating evidence indicates close associations between rhinitis and asthma, little is known about the relationships between occupational rhinitis (OR) and occupational asthma (OA). This study analyses the prevalence of OR associated with OA, globally and according to the various causal agents, and investigates the temporal relationships between these two conditions. Methods Data on incident cases of OA (2008–2010) were collected through the French national occupational disease surveillance and prevention network, using a standardised form including information on occupation, causal agents, presence of OR, and respective dates of occurrence of rhinitis and asthma. Results Among the 596 reported OA cases with latency period, 555 could be attributed to identified agents: high molecular weight (HMW) agents (n=174); low molecular weight (LMW) agents (n=381). Overall, OR was associated with OA in 324 (58.4%) cases. The frequency of association was significantly higher for HMW agents than for LMW agents (72.2% vs 51.5%, p<0.001). OR occurred before OA significantly more frequently for HMW agents than for LMW agents (p<0.01). Conclusions These results show that OR is frequently associated with OA, especially when HMW agents are involved. They are consistent with the hypothesis that OR, in conjunction with OA, is more likely to be caused by sensitisers that cause disease via IgE-mediated mechanisms and suggest that symptoms of OR should be taken into account in the medical surveillance of workers exposed to HMW agents.</div></front></TEI><istex><corpusName>bmj</corpusName><author><json:item><name>Jacques Ameille</name><affiliations><json:string>AP-HP, Occupational Health Department, Raymond Poincaré hospital, Garches, France</json:string><json:string>Institut interuniversitaire de médecine du travail, Paris, France</json:string></affiliations></json:item><json:item><name>Karine Hamelin</name><affiliations><json:string>Institut interuniversitaire de médecine du travail, Paris, France</json:string></affiliations></json:item><json:item><name>Pascal Andujar</name><affiliations><json:string>INSERM U 955, and Occupational Health Department, Créteil, France</json:string></affiliations></json:item><json:item><name>Lynda Bensefa-Colas</name><affiliations><json:string>AP-HP, Occupational Health Department, Cochin hospital, Paris, France</json:string></affiliations></json:item><json:item><name>Vincent Bonneterre</name><affiliations><json:string>UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525, Grenoble, France</json:string></affiliations></json:item><json:item><name>Dominique Dupas</name><affiliations><json:string>Occupational Health Department, University Hospital, Nantes, France</json:string></affiliations></json:item><json:item><name>Robert Garnier</name><affiliations><json:string>AP-HP, Occupational Health Department, Fernand-Widal Hospital, Paris, France</json:string></affiliations></json:item><json:item><name>Brice Alain Loddé</name><affiliations><json:string>Occupational Health Department, University Hospital, Brest, France</json:string></affiliations></json:item><json:item><name>Mickael Rinaldo</name><affiliations><json:string>Occupational Health Department, University Hospital, Bordeaux, France</json:string></affiliations></json:item><json:item><name>Alexis Descatha</name><affiliations><json:string>AP-HP, Occupational Health Department, Raymond Poincaré hospital, Garches, France</json:string></affiliations></json:item><json:item><name>Gérard Lasfargues</name><affiliations><json:string>Agence nationale de sécurité sanitaire, Maisons-Alfort, France</json:string></affiliations></json:item><json:item><name>Jean-Claude Pairon</name><affiliations><json:string>INSERM U 955, and Occupational Health Department, Créteil, France</json:string></affiliations></json:item></author><articleId><json:string>oemed-2012-101048</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>research-article</json:string></originalGenre><abstract>Objectives Whereas accumulating evidence indicates close associations between rhinitis and asthma, little is known about the relationships between occupational rhinitis (OR) and occupational asthma (OA). This study analyses the prevalence of OR associated with OA, globally and according to the various causal agents, and investigates the temporal relationships between these two conditions. Methods Data on incident cases of OA (2008–2010) were collected through the French national occupational disease surveillance and prevention network, using a standardised form including information on occupation, causal agents, presence of OR, and respective dates of occurrence of rhinitis and asthma. Results Among the 596 reported OA cases with latency period, 555 could be attributed to identified agents: high molecular weight (HMW) agents (n=174); low molecular weight (LMW) agents (n=381). Overall, OR was associated with OA in 324 (58.4%) cases. The frequency of association was significantly higher for HMW agents than for LMW agents (72.2% vs 51.5%, p>0.001). OR occurred before OA significantly more frequently for HMW agents than for LMW agents (p>0.01). Conclusions These results show that OR is frequently associated with OA, especially when HMW agents are involved. They are consistent with the hypothesis that OR, in conjunction with OA, is more likely to be caused by sensitisers that cause disease via IgE-mediated mechanisms and suggest that symptoms of OR should be taken into account in the medical surveillance of workers exposed to HMW agents.</abstract><qualityIndicators><score>6.821</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595.276 x 793.701 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>1558</abstractCharCount><pdfWordCount>4061</pdfWordCount><pdfCharCount>27356</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>230</abstractWordCount></qualityIndicators><title>Occupational asthma and occupational rhinitis: the united airways disease model revisited</title><pmid><json:string>23390199</json:string></pmid><corporate><json:item><name>the members of the rnv3p</name></json:item></corporate><genre><json:string>research-article</json:string></genre><host><volume>70</volume><publisherId><json:string>oem</json:string></publisherId><pages><first>471</first></pages><issn><json:string>1351-0711</json:string></issn><issue>7</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1470-7926</json:string></eissn><title>Occupational and Environmental Medicine</title></host><author_non-byline><json:item><name>C Doutrellot-Philippon</name></json:item><json:item><name>I Thaon</name></json:item><json:item><name>P Brochard</name></json:item><json:item><name>C Verdun-Esquer</name></json:item><json:item><name>JD Dewitte</name></json:item><json:item><name>B Lodde</name></json:item><json:item><name>M Letourneux</name></json:item><json:item><name>B Clin</name></json:item><json:item><name>MF Marquignon</name></json:item><json:item><name>A Chamoux</name></json:item><json:item><name>D Gabrillargues</name></json:item><json:item><name>JC Pairon</name></json:item><json:item><name>P Andujar</name></json:item><json:item><name>J Ameille</name></json:item><json:item><name>A Descatha</name></json:item><json:item><name>R de Gaudemaris</name></json:item><json:item><name>V Bonneterre</name></json:item><json:item><name>A Gislard</name></json:item><json:item><name>N Lepage</name></json:item><json:item><name>C Nisse</name></json:item><json:item><name>A Bergeret</name></json:item><json:item><name>JC Normand</name></json:item><json:item><name>MP Le Hucher-Michel</name></json:item><json:item><name>A Roulet</name></json:item><json:item><name>C Paris</name></json:item><json:item><name>E Penven</name></json:item><json:item><name>D Dupas</name></json:item><json:item><name>D Choudat</name></json:item><json:item><name>L Bensefa-Colas</name></json:item><json:item><name>R Garnier</name></json:item><json:item><name>A Villa</name></json:item><json:item><name>E Ben-Brik</name></json:item><json:item><name>C Berson</name></json:item><json:item><name>F Deschamps</name></json:item><json:item><name>FX Lesage</name></json:item><json:item><name>JF Gehanno</name></json:item><json:item><name>L Fontana</name></json:item><json:item><name>C Orset</name></json:item><json:item><name>A Cantineau</name></json:item><json:item><name>S Kleinogel</name></json:item><json:item><name>JM Soulat</name></json:item><json:item><name>F Hérin</name></json:item></author_non-byline><publicationDate>2013</publicationDate><copyrightDate>2013</copyrightDate><doi><json:string>10.1136/oemed-2012-101048</json:string></doi><id>80479D9602CE9DA591597EB74B87644289B6D6B6</id><score>0.12739113</score><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/80479D9602CE9DA591597EB74B87644289B6D6B6/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/80479D9602CE9DA591597EB74B87644289B6D6B6/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/80479D9602CE9DA591597EB74B87644289B6D6B6/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Occupational asthma and occupational rhinitis: the united airways disease model revisited</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>BMJ Publishing Group Ltd</publisher><availability><p>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</p></availability><date>2013-02-06</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Occupational asthma and occupational rhinitis: the united airways disease model revisited</title><author><orgName>the members of the rnv3p</orgName></author><author xml:id="author-2"><persName><forename type="first">Jacques</forename><surname>Ameille</surname></persName><affiliation>AP-HP, Occupational Health Department, Raymond Poincaré hospital, Garches, France</affiliation><affiliation>Institut interuniversitaire de médecine du travail, Paris, France</affiliation></author><author xml:id="author-3"><persName><forename type="first">Karine</forename><surname>Hamelin</surname></persName><affiliation>Institut interuniversitaire de médecine du travail, Paris, France</affiliation></author><author xml:id="author-4"><persName><forename type="first">Pascal</forename><surname>Andujar</surname></persName><affiliation>INSERM U 955, and Occupational Health Department, Créteil, France</affiliation></author><author xml:id="author-5"><persName><forename type="first">Lynda</forename><surname>Bensefa-Colas</surname></persName><affiliation>AP-HP, Occupational Health Department, Cochin hospital, Paris, France</affiliation></author><author xml:id="author-6"><persName><forename type="first">Vincent</forename><surname>Bonneterre</surname></persName><affiliation>UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525, Grenoble, France</affiliation></author><author xml:id="author-7"><persName><forename type="first">Dominique</forename><surname>Dupas</surname></persName><affiliation>Occupational Health Department, University Hospital, Nantes, France</affiliation></author><author xml:id="author-8"><persName><forename type="first">Robert</forename><surname>Garnier</surname></persName><affiliation>AP-HP, Occupational Health Department, Fernand-Widal Hospital, Paris, France</affiliation></author><author xml:id="author-9"><persName><forename type="first">Brice Alain</forename><surname>Loddé</surname></persName><affiliation>Occupational Health Department, University Hospital, Brest, France</affiliation></author><author xml:id="author-10"><persName><forename type="first">Mickael</forename><surname>Rinaldo</surname></persName><affiliation>Occupational Health Department, University Hospital, Bordeaux, France</affiliation></author><author xml:id="author-11"><persName><forename type="first">Alexis</forename><surname>Descatha</surname></persName><affiliation>AP-HP, Occupational Health Department, Raymond Poincaré hospital, Garches, France</affiliation></author><author xml:id="author-12"><persName><forename type="first">Gérard</forename><surname>Lasfargues</surname></persName><affiliation>Agence nationale de sécurité sanitaire, Maisons-Alfort, France</affiliation></author><author xml:id="author-13"><persName><forename type="first">Jean-Claude</forename><surname>Pairon</surname></persName><affiliation>INSERM U 955, and Occupational Health Department, Créteil, France</affiliation></author><author xml:id="author-14"><persName><forename type="first">C</forename><surname>Doutrellot-Philippon</surname></persName></author><author xml:id="author-15"><persName><forename type="first">I</forename><surname>Thaon</surname></persName></author><author xml:id="author-16"><persName><forename type="first">P</forename><surname>Brochard</surname></persName></author><author xml:id="author-17"><persName><forename type="first">C</forename><surname>Verdun-Esquer</surname></persName></author><author xml:id="author-18"><persName><forename type="first">JD</forename><surname>Dewitte</surname></persName></author><author xml:id="author-19"><persName><forename type="first">B</forename><surname>Lodde</surname></persName></author><author xml:id="author-20"><persName><forename type="first">M</forename><surname>Letourneux</surname></persName></author><author xml:id="author-21"><persName><forename type="first">B</forename><surname>Clin</surname></persName></author><author xml:id="author-22"><persName><forename type="first">MF</forename><surname>Marquignon</surname></persName></author><author xml:id="author-23"><persName><forename type="first">A</forename><surname>Chamoux</surname></persName></author><author xml:id="author-24"><persName><forename type="first">D</forename><surname>Gabrillargues</surname></persName></author><author xml:id="author-25"><persName><forename type="first">JC</forename><surname>Pairon</surname></persName></author><author xml:id="author-26"><persName><forename type="first">P</forename><surname>Andujar</surname></persName></author><author xml:id="author-27"><persName><forename type="first">J</forename><surname>Ameille</surname></persName></author><author xml:id="author-28"><persName><forename type="first">A</forename><surname>Descatha</surname></persName></author><author xml:id="author-29"><persName><forename type="first">R</forename><surname>de Gaudemaris</surname></persName></author><author xml:id="author-30"><persName><forename type="first">V</forename><surname>Bonneterre</surname></persName></author><author xml:id="author-31"><persName><forename type="first">A</forename><surname>Gislard</surname></persName></author><author xml:id="author-32"><persName><forename type="first">N</forename><surname>Lepage</surname></persName></author><author xml:id="author-33"><persName><forename type="first">C</forename><surname>Nisse</surname></persName></author><author xml:id="author-34"><persName><forename type="first">A</forename><surname>Bergeret</surname></persName></author><author xml:id="author-35"><persName><forename type="first">JC</forename><surname>Normand</surname></persName></author><author xml:id="author-36"><persName><forename type="first">MP</forename><surname>Le Hucher-Michel</surname></persName></author><author xml:id="author-37"><persName><forename type="first">A</forename><surname>Roulet</surname></persName></author><author xml:id="author-38"><persName><forename type="first">C</forename><surname>Paris</surname></persName></author><author xml:id="author-39"><persName><forename type="first">E</forename><surname>Penven</surname></persName></author><author xml:id="author-40"><persName><forename type="first">D</forename><surname>Dupas</surname></persName></author><author xml:id="author-41"><persName><forename type="first">D</forename><surname>Choudat</surname></persName></author><author xml:id="author-42"><persName><forename type="first">L</forename><surname>Bensefa-Colas</surname></persName></author><author xml:id="author-43"><persName><forename type="first">R</forename><surname>Garnier</surname></persName></author><author xml:id="author-44"><persName><forename type="first">A</forename><surname>Villa</surname></persName></author><author xml:id="author-45"><persName><forename type="first">E</forename><surname>Ben-Brik</surname></persName></author><author xml:id="author-46"><persName><forename type="first">C</forename><surname>Berson</surname></persName></author><author xml:id="author-47"><persName><forename type="first">F</forename><surname>Deschamps</surname></persName></author><author xml:id="author-48"><persName><forename type="first">FX</forename><surname>Lesage</surname></persName></author><author xml:id="author-49"><persName><forename type="first">JF</forename><surname>Gehanno</surname></persName></author><author xml:id="author-50"><persName><forename type="first">L</forename><surname>Fontana</surname></persName></author><author xml:id="author-51"><persName><forename type="first">C</forename><surname>Orset</surname></persName></author><author xml:id="author-52"><persName><forename type="first">A</forename><surname>Cantineau</surname></persName></author><author xml:id="author-53"><persName><forename type="first">S</forename><surname>Kleinogel</surname></persName></author><author xml:id="author-54"><persName><forename type="first">JM</forename><surname>Soulat</surname></persName></author><author xml:id="author-55"><persName><forename type="first">F</forename><surname>Hérin</surname></persName></author></analytic><monogr><title level="j">Occupational and Environmental Medicine</title><title level="j" type="abbrev">Occup Environ Med</title><idno type="pISSN">1351-0711</idno><idno type="eISSN">1470-7926</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2013-07"></date><biblScope unit="volume">70</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="471">471</biblScope></imprint></monogr><idno type="istex">80479D9602CE9DA591597EB74B87644289B6D6B6</idno><idno type="DOI">10.1136/oemed-2012-101048</idno><idno type="href">oemed-70-471.pdf</idno><idno type="ArticleID">oemed-2012-101048</idno><idno type="PMID">23390199</idno><idno type="local">oemed;70/7/471</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2013-02-06</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Objectives Whereas accumulating evidence indicates close associations between rhinitis and asthma, little is known about the relationships between occupational rhinitis (OR) and occupational asthma (OA). This study analyses the prevalence of OR associated with OA, globally and according to the various causal agents, and investigates the temporal relationships between these two conditions. Methods Data on incident cases of OA (2008–2010) were collected through the French national occupational disease surveillance and prevention network, using a standardised form including information on occupation, causal agents, presence of OR, and respective dates of occurrence of rhinitis and asthma. Results Among the 596 reported OA cases with latency period, 555 could be attributed to identified agents: high molecular weight (HMW) agents (n=174); low molecular weight (LMW) agents (n=381). Overall, OR was associated with OA in 324 (58.4%) cases. The frequency of association was significantly higher for HMW agents than for LMW agents (72.2% vs 51.5%, p<0.001). OR occurred before OA significantly more frequently for HMW agents than for LMW agents (p<0.01). Conclusions These results show that OR is frequently associated with OA, especially when HMW agents are involved. They are consistent with the hypothesis that OR, in conjunction with OA, is more likely to be caused by sensitisers that cause disease via IgE-mediated mechanisms and suggest that symptoms of OR should be taken into account in the medical surveillance of workers exposed to HMW agents.</p></abstract></profileDesc><revisionDesc><change when="2013-02-06">Created</change><change when="2013-07">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/80479D9602CE9DA591597EB74B87644289B6D6B6/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus bmj" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="no"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Archiving and Interchange DTD v2.3 20070202//EN" URI="archivearticle.dtd" 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pub-id-type="pmid">23390199</article-id><article-id pub-id-type="other">471</article-id><article-id pub-id-type="other">oemed-2012-101048</article-id><article-categories><subj-group subj-group-type="heading"><subject>Workplace</subject></subj-group><series-title>Original article</series-title></article-categories><title-group><article-title>Occupational asthma and occupational rhinitis: the united airways disease model revisited</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Ameille</surname><given-names>Jacques</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Hamelin</surname><given-names>Karine</given-names></name><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Andujar</surname><given-names>Pascal</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Bensefa-Colas</surname><given-names>Lynda</given-names></name><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Bonneterre</surname><given-names>Vincent</given-names></name><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Dupas</surname><given-names>Dominique</given-names></name><xref ref-type="aff" rid="af6">6</xref></contrib><contrib contrib-type="author"><name><surname>Garnier</surname><given-names>Robert</given-names></name><xref ref-type="aff" rid="af7">7</xref></contrib><contrib contrib-type="author"><name><surname>Loddé</surname><given-names>Brice Alain</given-names></name><xref ref-type="aff" rid="af8">8</xref></contrib><contrib contrib-type="author"><name><surname>Rinaldo</surname><given-names>Mickael</given-names></name><xref ref-type="aff" rid="af9">9</xref></contrib><contrib contrib-type="author"><name><surname>Descatha</surname><given-names>Alexis</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Lasfargues</surname><given-names>Gérard</given-names></name><xref ref-type="aff" rid="af10">10</xref></contrib><contrib contrib-type="author"><name><surname>Pairon</surname><given-names>Jean-Claude</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="contributor"><collab>the members of the rnv3p</collab></contrib><contrib contrib-type="author non-byline"><name><surname>Doutrellot-Philippon</surname><given-names>C</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Thaon</surname><given-names>I</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Brochard</surname><given-names>P</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Verdun-Esquer</surname><given-names>C</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Dewitte</surname><given-names>JD</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Lodde</surname><given-names>B</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Letourneux</surname><given-names>M</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Clin</surname><given-names>B</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Marquignon</surname><given-names>MF</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Chamoux</surname><given-names>A</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Gabrillargues</surname><given-names>D</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Pairon</surname><given-names>JC</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Andujar</surname><given-names>P</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Ameille</surname><given-names>J</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Descatha</surname><given-names>A</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>de Gaudemaris</surname><given-names>R</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Bonneterre</surname><given-names>V</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Gislard</surname><given-names>A</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Lepage</surname><given-names>N</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Nisse</surname><given-names>C</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Bergeret</surname><given-names>A</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Normand</surname><given-names>JC</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Le Hucher-Michel</surname><given-names>MP</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Roulet</surname><given-names>A</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Paris</surname><given-names>C</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Penven</surname><given-names>E</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Dupas</surname><given-names>D</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Choudat</surname><given-names>D</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Bensefa-Colas</surname><given-names>L</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Garnier</surname><given-names>R</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Villa</surname><given-names>A</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Ben-Brik</surname><given-names>E</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Berson</surname><given-names>C</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Deschamps</surname><given-names>F</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Lesage</surname><given-names>FX</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Gehanno</surname><given-names>JF</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Fontana</surname><given-names>L</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Orset</surname><given-names>C</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Cantineau</surname><given-names>A</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Kleinogel</surname><given-names>S</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Soulat</surname><given-names>JM</given-names></name></contrib><contrib contrib-type="author non-byline"><name><surname>Hérin</surname><given-names>F</given-names></name></contrib></contrib-group><aff id="af1"><label>1</label><addr-line>AP-HP, Occupational Health Department</addr-line>, <institution>Raymond Poincaré hospital</institution>, <addr-line>Garches</addr-line>, <country>France</country></aff><aff id="af2"><label>2</label><institution>Institut interuniversitaire de médecine du travail</institution>, <addr-line>Paris</addr-line>, <country>France</country></aff><aff id="af3"><label>3</label><addr-line>INSERM U 955, and Occupational Health Department, Créteil</addr-line>, <country>France</country></aff><aff id="af4"><label>4</label><addr-line>AP-HP, Occupational Health Department</addr-line>, <institution>Cochin hospital</institution>, <addr-line>Paris</addr-line>, <country>France</country></aff><aff id="af5"><label>5</label><addr-line>UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525, Grenoble</addr-line>, <country>France</country></aff><aff id="af6"><label>6</label><addr-line>Occupational Health Department</addr-line>, <institution>University Hospital</institution>, <addr-line>Nantes</addr-line>, <country>France</country></aff><aff id="af7"><label>7</label><addr-line>AP-HP, Occupational Health Department</addr-line>, <institution>Fernand-Widal Hospital</institution>, <addr-line>Paris</addr-line>, <country>France</country></aff><aff id="af8"><label>8</label><addr-line>Occupational Health Department</addr-line>, <institution>University Hospital</institution>, <addr-line>Brest</addr-line>, <country>France</country></aff><aff id="af9"><label>9</label><addr-line>Occupational Health Department</addr-line>, <institution>University Hospital</institution>, <addr-line>Bordeaux</addr-line>, <country>France</country></aff><aff id="af10"><label>10</label><institution>Agence nationale de sécurité sanitaire</institution>, <addr-line>Maisons-Alfort</addr-line>, <country>France</country></aff><author-notes><corresp><label>Correspondence to</label> Professor Jacques Ameille, AP-HP, Occupational Health Department, Unité de pathologie professionnelle, Hôpital Raymond Poincaré, 104 Boulevard Raymond Poincaré, Garches 92380, France; <email>jacques.ameille@rpc.aphp.fr</email></corresp></author-notes><pub-date pub-type="ppub"><month>7</month><year>2013</year></pub-date><pub-date pub-type="epub-original"><day>6</day><month>2</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>6</day><month>2</month><year>2013</year></pub-date><volume>70</volume><volume-id pub-id-type="other">70</volume-id><volume-id pub-id-type="other">70</volume-id><issue>7</issue><issue-id pub-id-type="other">oemed;70/7</issue-id><issue-id pub-id-type="other">7</issue-id><issue-id pub-id-type="other">70/7</issue-id><fpage>471</fpage><history><date date-type="received"><day>5</day><month>7</month><year>2013</year></date><date date-type="rev-recd"><day>3</day><month>12</month><year>2013</year></date><date date-type="accepted"><day>9</day><month>1</month><year>2013</year></date></history><permissions><copyright-statement>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</copyright-statement><copyright-year>2013</copyright-year></permissions><self-uri content-type="pdf" xlink:role="full-text" xlink:href="oemed-70-471.pdf"></self-uri><abstract><sec><title>Objectives</title><p>Whereas accumulating evidence indicates close associations between rhinitis and asthma, little is known about the relationships between occupational rhinitis (OR) and occupational asthma (OA). This study analyses the prevalence of OR associated with OA, globally and according to the various causal agents, and investigates the temporal relationships between these two conditions.</p></sec><sec><title>Methods</title><p>Data on incident cases of OA (2008–2010) were collected through the French national occupational disease surveillance and prevention network, using a standardised form including information on occupation, causal agents, presence of OR, and respective dates of occurrence of rhinitis and asthma.</p></sec><sec><title>Results</title><p>Among the 596 reported OA cases with latency period, 555 could be attributed to identified agents: high molecular weight (HMW) agents (n=174); low molecular weight (LMW) agents (n=381). Overall, OR was associated with OA in 324 (58.4%) cases. The frequency of association was significantly higher for HMW agents than for LMW agents (72.2% vs 51.5%, p<0.001). OR occurred before OA significantly more frequently for HMW agents than for LMW agents (p<0.01).</p></sec><sec><title>Conclusions</title><p>These results show that OR is frequently associated with OA, especially when HMW agents are involved. They are consistent with the hypothesis that OR, in conjunction with OA, is more likely to be caused by sensitisers that cause disease via IgE-mediated mechanisms and suggest that symptoms of OR should be taken into account in the medical surveillance of workers exposed to HMW agents.</p></sec></abstract></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Occupational asthma and occupational rhinitis: the united airways disease model revisited</title><partName>Original article</partName></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Occupational asthma and occupational rhinitis: the united airways disease model revisited</title><partName>Original article</partName></titleInfo><name type="corporate"><namePart>the members of the rnv3p</namePart></name><name type="personal"><namePart type="given">Jacques</namePart><namePart type="family">Ameille</namePart><affiliation>AP-HP, Occupational Health Department, Raymond Poincaré hospital, Garches, France</affiliation><affiliation>Institut interuniversitaire de médecine du travail, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Karine</namePart><namePart type="family">Hamelin</namePart><affiliation>Institut interuniversitaire de médecine du travail, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pascal</namePart><namePart type="family">Andujar</namePart><affiliation>INSERM U 955, and Occupational Health Department, Créteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lynda</namePart><namePart type="family">Bensefa-Colas</namePart><affiliation>AP-HP, Occupational Health Department, Cochin hospital, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Vincent</namePart><namePart type="family">Bonneterre</namePart><affiliation>UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525, Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dominique</namePart><namePart type="family">Dupas</namePart><affiliation>Occupational Health Department, University Hospital, Nantes, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Robert</namePart><namePart type="family">Garnier</namePart><affiliation>AP-HP, Occupational Health Department, Fernand-Widal Hospital, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Brice Alain</namePart><namePart type="family">Loddé</namePart><affiliation>Occupational Health Department, University Hospital, Brest, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mickael</namePart><namePart type="family">Rinaldo</namePart><affiliation>Occupational Health Department, University Hospital, Bordeaux, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alexis</namePart><namePart type="family">Descatha</namePart><affiliation>AP-HP, Occupational Health Department, Raymond Poincaré hospital, Garches, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gérard</namePart><namePart type="family">Lasfargues</namePart><affiliation>Agence nationale de sécurité sanitaire, Maisons-Alfort, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean-Claude</namePart><namePart type="family">Pairon</namePart><affiliation>INSERM U 955, and Occupational Health Department, Créteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Doutrellot-Philippon</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Thaon</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Brochard</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Verdun-Esquer</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">JD</namePart><namePart type="family">Dewitte</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Lodde</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Letourneux</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Clin</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">MF</namePart><namePart type="family">Marquignon</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Chamoux</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Gabrillargues</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">JC</namePart><namePart type="family">Pairon</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Andujar</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Ameille</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Descatha</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">de Gaudemaris</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Bonneterre</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Gislard</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Lepage</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Nisse</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Bergeret</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">JC</namePart><namePart type="family">Normand</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">MP</namePart><namePart type="family">Le Hucher-Michel</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Roulet</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Paris</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Penven</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Dupas</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Choudat</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Bensefa-Colas</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Garnier</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Villa</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Ben-Brik</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Berson</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Deschamps</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">FX</namePart><namePart type="family">Lesage</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">JF</namePart><namePart type="family">Gehanno</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Fontana</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Orset</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Cantineau</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Kleinogel</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">JM</namePart><namePart type="family">Soulat</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Hérin</namePart><role><roleTerm type="text">author non-byline</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><originInfo><publisher>BMJ Publishing Group Ltd</publisher><dateIssued encoding="w3cdtf">2013-07</dateIssued><dateCreated encoding="w3cdtf">2013-02-06</dateCreated><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>Objectives Whereas accumulating evidence indicates close associations between rhinitis and asthma, little is known about the relationships between occupational rhinitis (OR) and occupational asthma (OA). This study analyses the prevalence of OR associated with OA, globally and according to the various causal agents, and investigates the temporal relationships between these two conditions. Methods Data on incident cases of OA (2008–2010) were collected through the French national occupational disease surveillance and prevention network, using a standardised form including information on occupation, causal agents, presence of OR, and respective dates of occurrence of rhinitis and asthma. Results Among the 596 reported OA cases with latency period, 555 could be attributed to identified agents: high molecular weight (HMW) agents (n=174); low molecular weight (LMW) agents (n=381). Overall, OR was associated with OA in 324 (58.4%) cases. The frequency of association was significantly higher for HMW agents than for LMW agents (72.2% vs 51.5%, p<0.001). OR occurred before OA significantly more frequently for HMW agents than for LMW agents (p<0.01). Conclusions These results show that OR is frequently associated with OA, especially when HMW agents are involved. They are consistent with the hypothesis that OR, in conjunction with OA, is more likely to be caused by sensitisers that cause disease via IgE-mediated mechanisms and suggest that symptoms of OR should be taken into account in the medical surveillance of workers exposed to HMW agents.</abstract><relatedItem type="host"><titleInfo><title>Occupational and Environmental Medicine</title></titleInfo><titleInfo type="abbreviated"><title>Occup Environ Med</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">1351-0711</identifier><identifier type="eISSN">1470-7926</identifier><identifier type="PublisherID">oem</identifier><identifier type="PublisherID-hwp">oemed</identifier><identifier type="PublisherID-nlm-ta">Occup Environ Med</identifier><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>70</number></detail><detail type="issue"><caption>no.</caption><number>7</number></detail><extent unit="pages"><start>471</start></extent></part></relatedItem><identifier type="istex">80479D9602CE9DA591597EB74B87644289B6D6B6</identifier><identifier type="DOI">10.1136/oemed-2012-101048</identifier><identifier type="href">oemed-70-471.pdf</identifier><identifier type="ArticleID">oemed-2012-101048</identifier><identifier type="PMID">23390199</identifier><identifier type="local">oemed;70/7/471</identifier><accessCondition type="use and reproduction" contentType="copyright">Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</accessCondition><recordInfo><recordContentSource>BMJ</recordContentSource></recordInfo></mods></metadata><enrichments><json:item><type>multicat</type><uri>https://api.istex.fr/document/80479D9602CE9DA591597EB74B87644289B6D6B6/enrichments/multicat</uri></json:item></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Occupational asthma and occupational rhinitis: the united airways disease model revisited
}}
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