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Childhood‐onset psoriasis: association with future cardiovascular and metabolic comorbidities

Identifieur interne : 001262 ( Istex/Corpus ); précédent : 001261; suivant : 001263

Childhood‐onset psoriasis: association with future cardiovascular and metabolic comorbidities

Auteurs : E. Mahé ; F. Maccari ; A. Beauchet ; M. Lahfa ; H. Barthelemy ; Z. Reguiaï ; N. Beneton ; E. Estève ; G. Chaby ; M. Ruer-Mulard ; H. Steiner ; C. Pauwels ; M. Avenel-Audran ; C. Goujon-Henry ; V. Descamps ; E. Begon ; M. Sigal

Source :

RBID : ISTEX:A2D4FDC2A406FD8576172A43DC488F4AEEA4F1C2

Abstract

Psoriasis is associated with higher prevalences of cardiovascular and metabolic comorbidities in adults but the relationship of age at onset and those prevalences is unknown.

Url:
DOI: 10.1111/bjd.12441

Links to Exploration step

ISTEX:A2D4FDC2A406FD8576172A43DC488F4AEEA4F1C2

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<forename type="first">M.</forename>
<surname>Lahfa</surname>
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<affiliation>Department of Dermatology, Hôpital Larrey, Centre Hospitalier Universitaire de Toulouse, Paul Sabatier–Toulouse 3 University, Toulouse, France</affiliation>
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<author xml:id="author-5">
<persName>
<forename type="first">H.</forename>
<surname>Barthelemy</surname>
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<affiliation>Department of Dermatology, Centre Hospitalier d'Auxerre, Auxerre, France</affiliation>
</author>
<author xml:id="author-6">
<persName>
<forename type="first">Z.</forename>
<surname>Reguiaï</surname>
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<affiliation>Department of Dermatology, Hôpital Robert Debré, Reims, France</affiliation>
</author>
<author xml:id="author-7">
<persName>
<forename type="first">N.</forename>
<surname>Beneton</surname>
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<affiliation>Department of Dermatology, Centre Hospitalier du Mans, Le Mans, France</affiliation>
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<author xml:id="author-8">
<persName>
<forename type="first">E.</forename>
<surname>Estève</surname>
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<affiliation>Department of Dermatology, Centre Hospitalier Régional d'Orléans, Orléans, France</affiliation>
</author>
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<persName>
<forename type="first">G.</forename>
<surname>Chaby</surname>
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<affiliation>Department of Dermatology, Hôpital Sud, Centre Hospitalier Universitaire d'Amiens, Picardie‐Jules Verne University, Amiens, France</affiliation>
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<persName>
<forename type="first">M.</forename>
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<persName>
<forename type="first">C.</forename>
<surname>Pauwels</surname>
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</author>
<author xml:id="author-13">
<persName>
<forename type="first">M.</forename>
<surname>Avenel‐Audran</surname>
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<affiliation>Department of Dermatology, Angers Hospital, L'UNAM University, Angers, France</affiliation>
</author>
<author xml:id="author-14">
<persName>
<forename type="first">C.</forename>
<surname>Goujon‐Henry</surname>
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<forename type="first">V.</forename>
<surname>Descamps</surname>
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<affiliation>Department of Dermatology, Centre Hospitalier Universitaire Bichat‐Claude Bernard, Paris 7 Diderot University, Assitance Publique‐Hôpitaux de Paris, Paris, France</affiliation>
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<author xml:id="author-16">
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<forename type="first">E.</forename>
<surname>Begon</surname>
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<affiliation>Department of Dermatology, Centre Hospitalier de Pontoise, Pontoise, France</affiliation>
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<author xml:id="author-17">
<persName>
<forename type="first">M.‐L.</forename>
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<p>Psoriasis is associated with higher prevalences of cardiovascular and metabolic comorbidities in adults but the relationship of age at onset and those prevalences is unknown.</p>
</abstract>
<abstract>
<p>To evaluate whether the childhood onset of psoriasis (COP) is correlated with the frequency of cardiovascular and metabolic comorbidities in adulthood.</p>
</abstract>
<abstract>
<p>This noninterventional, cross‐sectional, multicentre study of adults with psoriasis was conducted in 29 dermatology centres in France. Data on sex, age at onset of psoriasis and its clinical characteristics, and cardiovascular risk factors, including weight, body mass index, waist circumference, dyslipidaemia, diabetes, hypertension, smoking, and personal/familial major adverse cardiovascular events (MACE) were systematically recorded.</p>
</abstract>
<abstract>
<p>Two thousand two hundred and one patients with psoriasis (male: 56%; mean age: 49 years; 25% with COP) were included consecutively in the study. Univariate analysis showed that COP was associated with lower frequencies of obesity, high waist circumference, diabetes, dyslipidaemia, hypertension, familial cardiovascular disease, MACE and metabolic syndrome, but more frequent active smoking. Multivariate analysis retained age as being associated with frequency of cardiovascular and metabolic comorbidities, and sex with smoking, but not age at the onset of psoriasis. Psoriasis severity was associated with higher frequencies of obesity and psoriatic arthritis.</p>
</abstract>
<abstract>
<p>Our results showed that COP does not seem to be an additional risk factor for higher frequencies of cardiovascular and metabolic comorbidities during adulthood.</p>
</abstract>
<abstract>
<p>What's already known about this topic?</p>
</abstract>
<abstract>
<p>Psoriasis and its severity are associated with higher prevalence of cardiovascular and metabolic comorbidities in adults. Childhood onset of psoriasis is not associated with obesity in adulthood.</p>
</abstract>
<abstract>
<p>What does this study add?</p>
</abstract>
<abstract>
<p>Childhood onset of psoriasis is not associated with cardiovascular and metabolic comorbidities in adulthood. In France, as in most countries, psoriasis is associated with high frequencies of cardiovascular and metabolic comorbidities in adults.</p>
</abstract>
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<i>Emmanuel Mahé</i>
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<i>E‐mail</i>
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<email>emmanuel.mahe@ch-argenteuil.fr</email>
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<personName>
<givenNames>M.‐L.</givenNames>
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<creator creatorRole="author" xml:id="bjd12441-cr-0018">
<groupName>for the GEM Resopso</groupName>
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<affiliationGroup>
<affiliation countryCode="FR" type="organization" xml:id="bjd12441-aff-0001">
<orgDiv>Department of Dermatology</orgDiv>
<orgName>Hôpital Victor Dupouy</orgName>
<address>
<city>Argenteuil</city>
<country>France</country>
</address>
</affiliation>
<affiliation countryCode="FR" type="organization" xml:id="bjd12441-aff-0002">
<orgDiv>Department of Dermatology</orgDiv>
<orgName>Hôpital d'Instruction des Armées Bégin</orgName>
<address>
<city>Saint‐Mandé</city>
<country>France</country>
</address>
</affiliation>
<affiliation countryCode="FR" type="organization" xml:id="bjd12441-aff-0003">
<orgDiv>Department of Public Health</orgDiv>
<orgName>Centre Hospitalier Universitaire Ambroise Paré</orgName>
<orgName>University of Versailles‐Saint‐Quentin‐en‐Yvelines</orgName>
<orgName>Assistance Publique‐Hôpitaux de Paris</orgName>
<address>
<city>Boulogne‐Billancourt</city>
<country>France</country>
</address>
</affiliation>
<affiliation countryCode="FR" type="organization" xml:id="bjd12441-aff-0004">
<orgDiv>Department of Dermatology</orgDiv>
<orgName>Hôpital Larrey</orgName>
<orgName>Centre Hospitalier Universitaire de Toulouse</orgName>
<orgName>Paul Sabatier–Toulouse 3 University</orgName>
<address>
<city>Toulouse</city>
<country>France</country>
</address>
</affiliation>
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<orgDiv>Department of Dermatology</orgDiv>
<orgName>Centre Hospitalier d'Auxerre</orgName>
<address>
<city>Auxerre</city>
<country>France</country>
</address>
</affiliation>
<affiliation countryCode="FR" type="organization" xml:id="bjd12441-aff-0006">
<orgDiv>Department of Dermatology</orgDiv>
<orgName>Hôpital Robert Debré</orgName>
<address>
<city>Reims</city>
<country>France</country>
</address>
</affiliation>
<affiliation countryCode="FR" type="organization" xml:id="bjd12441-aff-0007">
<orgDiv>Department of Dermatology</orgDiv>
<orgName>Centre Hospitalier du Mans</orgName>
<address>
<city>Le Mans</city>
<country>France</country>
</address>
</affiliation>
<affiliation countryCode="FR" type="organization" xml:id="bjd12441-aff-0008">
<orgDiv>Department of Dermatology</orgDiv>
<orgName>Centre Hospitalier Régional d'Orléans</orgName>
<address>
<city>Orléans</city>
<country>France</country>
</address>
</affiliation>
<affiliation countryCode="FR" type="organization" xml:id="bjd12441-aff-0009">
<orgDiv>Department of Dermatology</orgDiv>
<orgName>Hôpital Sud</orgName>
<orgName>Centre Hospitalier Universitaire d'Amiens</orgName>
<orgName>Picardie‐Jules Verne University</orgName>
<address>
<city>Amiens</city>
<country>France</country>
</address>
</affiliation>
<affiliation countryCode="FR" type="organization" xml:id="bjd12441-aff-0010">
<orgName>Private office</orgName>
<address>
<city>Martigues</city>
<country>France</country>
</address>
</affiliation>
<affiliation countryCode="FR" type="organization" xml:id="bjd12441-aff-0011">
<orgName>Private office</orgName>
<address>
<city>Vienne</city>
<country>France</country>
</address>
</affiliation>
<affiliation countryCode="FR" type="organization" xml:id="bjd12441-aff-0012">
<orgDiv>Department of Dermatology</orgDiv>
<orgName>Centre Hospitalier Intercommunal Poissy/Saint‐Germain‐en‐Laye</orgName>
<address>
<city>Saint‐Germain‐en‐Laye</city>
<country>France</country>
</address>
</affiliation>
<affiliation countryCode="FR" type="organization" xml:id="bjd12441-aff-0013">
<orgDiv>Department of Dermatology</orgDiv>
<orgName>Angers Hospital</orgName>
<orgName>L'UNAM University</orgName>
<address>
<city>Angers</city>
<country>France</country>
</address>
</affiliation>
<affiliation countryCode="FR" type="organization" xml:id="bjd12441-aff-0014">
<orgDiv>Department of Clinical Immunology and Allergy</orgDiv>
<orgName>Centre Hospitalier Lyon‐Sud</orgName>
<address>
<city>Lyon</city>
<country>France</country>
</address>
</affiliation>
<affiliation countryCode="FR" type="organization" xml:id="bjd12441-aff-0015">
<orgDiv>Department of Dermatology</orgDiv>
<orgName>Centre Hospitalier Universitaire Bichat‐Claude Bernard</orgName>
<orgName>Paris 7 Diderot University</orgName>
<orgName>Assitance Publique‐Hôpitaux de Paris</orgName>
<address>
<city>Paris</city>
<country>France</country>
</address>
</affiliation>
<affiliation countryCode="FR" type="organization" xml:id="bjd12441-aff-0016">
<orgDiv>Department of Dermatology</orgDiv>
<orgName>Centre Hospitalier de Pontoise</orgName>
<address>
<city>Pontoise</city>
<country>France</country>
</address>
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<title type="main">Summary</title>
<section xml:id="bjd12441-sec-0001">
<title type="main">Background</title>
<p>Psoriasis is associated with higher prevalences of cardiovascular and metabolic comorbidities in adults but the relationship of age at onset and those prevalences is unknown.</p>
</section>
<section xml:id="bjd12441-sec-0002">
<title type="main">Objective</title>
<p>To evaluate whether the childhood onset of psoriasis (
<fc>COP</fc>
) is correlated with the frequency of cardiovascular and metabolic comorbidities in adulthood.</p>
</section>
<section xml:id="bjd12441-sec-0003">
<title type="main">Methods</title>
<p>This noninterventional, cross‐sectional, multicentre study of adults with psoriasis was conducted in 29 dermatology centres in France. Data on sex, age at onset of psoriasis and its clinical characteristics, and cardiovascular risk factors, including weight, body mass index, waist circumference, dyslipidaemia, diabetes, hypertension, smoking, and personal/familial major adverse cardiovascular events (
<fc>MACE</fc>
) were systematically recorded.</p>
</section>
<section xml:id="bjd12441-sec-0004">
<title type="main">Results</title>
<p>Two thousand two hundred and one patients with psoriasis (male: 56%; mean age: 49 years; 25% with
<fc>COP</fc>
) were included consecutively in the study. Univariate analysis showed that
<fc>COP</fc>
was associated with lower frequencies of obesity, high waist circumference, diabetes, dyslipidaemia, hypertension, familial cardiovascular disease,
<fc>MACE</fc>
and metabolic syndrome, but more frequent active smoking. Multivariate analysis retained age as being associated with frequency of cardiovascular and metabolic comorbidities, and sex with smoking, but not age at the onset of psoriasis. Psoriasis severity was associated with higher frequencies of obesity and psoriatic arthritis.</p>
</section>
<section xml:id="bjd12441-sec-0005">
<title type="main">Conclusion</title>
<p>Our results showed that
<fc>COP</fc>
does not seem to be an additional risk factor for higher frequencies of cardiovascular and metabolic comorbidities during adulthood.</p>
</section>
</abstract>
<abstract type="short" xml:id="bjd12441-abs-0002" xml:lang="en">
<p>
<b>What's already known about this topic?</b>
</p>
<p>
<list formatted="paragraph" style="bulleted" xml:id="bjd12441-list-0001">
<listItem>Psoriasis and its severity are associated with higher prevalence of cardiovascular and metabolic comorbidities in adults.</listItem>
<listItem>Childhood onset of psoriasis is not associated with obesity in adulthood.</listItem>
</list>
</p>
<p>
<b>What does this study add?</b>
</p>
<p>
<list formatted="paragraph" style="bulleted" xml:id="bjd12441-list-0002">
<listItem>Childhood onset of psoriasis is not associated with cardiovascular and metabolic comorbidities in adulthood.</listItem>
<listItem>In
<fc>F</fc>
rance, as in most countries, psoriasis is associated with high frequencies of cardiovascular and metabolic comorbidities in adults.</listItem>
</list>
</p>
</abstract>
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<b>Funding sources</b>
None</note>
<note numbered="no" xml:id="bjd12441-note-0002">
<b>Conflicts of interest</b>
Authors declare no conflict of interest in this study</note>
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<affiliation>Department of Dermatology, Hôpital Larrey, Centre Hospitalier Universitaire de Toulouse, Paul Sabatier–Toulouse 3 University, Toulouse, France</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">H.</namePart>
<namePart type="family">Barthelemy</namePart>
<affiliation>Department of Dermatology, Centre Hospitalier d'Auxerre, Auxerre, France</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">Z.</namePart>
<namePart type="family">Reguiaï</namePart>
<affiliation>Department of Dermatology, Hôpital Robert Debré, Reims, France</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">N.</namePart>
<namePart type="family">Beneton</namePart>
<affiliation>Department of Dermatology, Centre Hospitalier du Mans, Le Mans, France</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">E.</namePart>
<namePart type="family">Estève</namePart>
<affiliation>Department of Dermatology, Centre Hospitalier Régional d'Orléans, Orléans, France</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">G.</namePart>
<namePart type="family">Chaby</namePart>
<affiliation>Department of Dermatology, Hôpital Sud, Centre Hospitalier Universitaire d'Amiens, Picardie‐Jules Verne University, Amiens, France</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">M.</namePart>
<namePart type="family">Ruer‐Mulard</namePart>
<affiliation>Private office, Martigues, France</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">H.‐G.</namePart>
<namePart type="family">Steiner</namePart>
<affiliation>Private office, Vienne, France</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">C.</namePart>
<namePart type="family">Pauwels</namePart>
<affiliation>Department of Dermatology, Centre Hospitalier Intercommunal Poissy/Saint‐Germain‐en‐Laye, Saint‐Germain‐en‐Laye, France</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">M.</namePart>
<namePart type="family">Avenel‐Audran</namePart>
<affiliation>Department of Dermatology, Angers Hospital, L'UNAM University, Angers, France</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">C.</namePart>
<namePart type="family">Goujon‐Henry</namePart>
<affiliation>Department of Clinical Immunology and Allergy, Centre Hospitalier Lyon‐Sud, Lyon, France</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">V.</namePart>
<namePart type="family">Descamps</namePart>
<affiliation>Department of Dermatology, Centre Hospitalier Universitaire Bichat‐Claude Bernard, Paris 7 Diderot University, Assitance Publique‐Hôpitaux de Paris, Paris, France</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">E.</namePart>
<namePart type="family">Begon</namePart>
<affiliation>Department of Dermatology, Centre Hospitalier de Pontoise, Pontoise, France</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">M.‐L.</namePart>
<namePart type="family">Sigal</namePart>
<affiliation>Department of Dermatology, Hôpital Victor Dupouy, Argenteuil, France</affiliation>
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<roleTerm type="text">author</roleTerm>
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<publisher>Blackwell Publishing Ltd</publisher>
<dateIssued encoding="w3cdtf">2013-10</dateIssued>
<dateCreated encoding="w3cdtf">2013-08-08</dateCreated>
<dateValid encoding="w3cdtf">2013-05-11</dateValid>
<copyrightDate encoding="w3cdtf">2013</copyrightDate>
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<abstract>Psoriasis is associated with higher prevalences of cardiovascular and metabolic comorbidities in adults but the relationship of age at onset and those prevalences is unknown.</abstract>
<abstract>To evaluate whether the childhood onset of psoriasis (COP) is correlated with the frequency of cardiovascular and metabolic comorbidities in adulthood.</abstract>
<abstract>This noninterventional, cross‐sectional, multicentre study of adults with psoriasis was conducted in 29 dermatology centres in France. Data on sex, age at onset of psoriasis and its clinical characteristics, and cardiovascular risk factors, including weight, body mass index, waist circumference, dyslipidaemia, diabetes, hypertension, smoking, and personal/familial major adverse cardiovascular events (MACE) were systematically recorded.</abstract>
<abstract>Two thousand two hundred and one patients with psoriasis (male: 56%; mean age: 49 years; 25% with COP) were included consecutively in the study. Univariate analysis showed that COP was associated with lower frequencies of obesity, high waist circumference, diabetes, dyslipidaemia, hypertension, familial cardiovascular disease, MACE and metabolic syndrome, but more frequent active smoking. Multivariate analysis retained age as being associated with frequency of cardiovascular and metabolic comorbidities, and sex with smoking, but not age at the onset of psoriasis. Psoriasis severity was associated with higher frequencies of obesity and psoriatic arthritis.</abstract>
<abstract>Our results showed that COP does not seem to be an additional risk factor for higher frequencies of cardiovascular and metabolic comorbidities during adulthood.</abstract>
<abstract>What's already known about this topic?</abstract>
<abstract>Psoriasis and its severity are associated with higher prevalence of cardiovascular and metabolic comorbidities in adults. Childhood onset of psoriasis is not associated with obesity in adulthood.</abstract>
<abstract>What does this study add?</abstract>
<abstract>Childhood onset of psoriasis is not associated with cardiovascular and metabolic comorbidities in adulthood. In France, as in most countries, psoriasis is associated with high frequencies of cardiovascular and metabolic comorbidities in adults.</abstract>
<relatedItem type="host">
<titleInfo>
<title>British Journal of Dermatology</title>
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<titleInfo type="abbreviated">
<title>Br J Dermatol</title>
</titleInfo>
<genre type="journal">journal</genre>
<subject>
<genre>article-category</genre>
<topic>Paediatric Dermatology</topic>
</subject>
<identifier type="ISSN">0007-0963</identifier>
<identifier type="eISSN">1365-2133</identifier>
<identifier type="DOI">10.1111/(ISSN)1365-2133</identifier>
<identifier type="PublisherID">BJD</identifier>
<part>
<date>2013</date>
<detail type="volume">
<caption>vol.</caption>
<number>169</number>
</detail>
<detail type="issue">
<caption>no.</caption>
<number>4</number>
</detail>
<extent unit="pages">
<start>889</start>
<end>895</end>
<total>7</total>
</extent>
</part>
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<identifier type="istex">A2D4FDC2A406FD8576172A43DC488F4AEEA4F1C2</identifier>
<identifier type="DOI">10.1111/bjd.12441</identifier>
<identifier type="ArticleID">BJD12441</identifier>
<accessCondition type="use and reproduction" contentType="copyright">BJD © 2013 British Association of Dermatologists© 2013 The Authors BJD © 2013 British Association of Dermatologists</accessCondition>
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