Fetal serum β2‐microglobulin as a marker for fetal infectious diseases
Identifieur interne : 000896 ( Istex/Corpus ); précédent : 000895; suivant : 000897Fetal serum β2‐microglobulin as a marker for fetal infectious diseases
Auteurs : Sophie Dreux ; Thierry Rousseau ; Stefan Gerber ; Jean-Yves Col ; Marc Dommergues ; Françoise MullerSource :
- Prenatal Diagnosis [ 0197-3851 ] ; 2006-05.
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Abstract
To evaluate whether fetal serum β2‐microglobulin could be used as a marker of fetal cytomegalovirus (CMV) or toxoplasmosis infection.
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DOI: 10.1002/pd.1441
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ISTEX:64AF04FB3FC3A8E43769BE70B33509B986B472EBLe document en format XML
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type="first">Thierry</forename><surname>Rousseau</surname></persName><affiliation>Gynécologie‐Obstétrique, Maternité du Bocage, 21000, Dijon, France</affiliation></author><author xml:id="author-3"><persName><forename type="first">Stefan</forename><surname>Gerber</surname></persName><affiliation>Gynécologie‐Obstétrique, CHUV de Lausanne, 1011 Lausanne VD, Suisse</affiliation></author><author xml:id="author-4"><persName><forename type="first">Jean‐Yves</forename><surname>Col</surname></persName><affiliation>Gynécologie‐Obstétrique, Centre Hospitalier, Le Havre, France</affiliation></author><author xml:id="author-5"><persName><forename type="first">Marc</forename><surname>Dommergues</surname></persName><affiliation>Gynécologie‐Obstétrique, Hôpital Necker, AP‐HP, Paris, France</affiliation></author><author xml:id="author-6"><persName><forename type="first">Françoise</forename><surname>Muller</surname></persName><note type="correspondence"><p>Correspondence: Biochimie Hormonologie, Hôpital Robert Debré, 48, Bd Sérurier, 75935 Paris Cedex 19, France.</p></note><affiliation>Biochimie‐Hormonologie, Hôpital Robert Debré, AP‐HP, Paris, France</affiliation><affiliation>Université Paris Ile de France Ouest, Paris, France</affiliation></author></analytic><monogr><title level="j">Prenatal Diagnosis</title><title level="j" type="sub">Published in Affiliation With the International Society for Prenatal Diagnosis</title><title level="j" type="abbrev">Prenat. Diagn.</title><idno type="pISSN">0197-3851</idno><idno type="eISSN">1097-0223</idno><idno type="DOI">10.1002/(ISSN)1097-0223</idno><imprint><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2006-05"></date><biblScope unit="volume">26</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="471">471</biblScope><biblScope unit="page" to="474">474</biblScope></imprint></monogr><idno type="istex">64AF04FB3FC3A8E43769BE70B33509B986B472EB</idno><idno type="DOI">10.1002/pd.1441</idno><idno type="ArticleID">PD1441</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2006</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>To evaluate whether fetal serum β2‐microglobulin could be used as a marker of fetal cytomegalovirus (CMV) or toxoplasmosis infection.</p></abstract><abstract><p>β2‐microglobulin was retrospectively assayed in fetal serum collected from 64 patients with maternal infectious seroconversion (toxoplasmosis in 49 cases, CMV in 15). Using a β2‐microglobulin cutoff of 5 mg/L, infection and control groups were compared.</p></abstract><abstract><p>Fetal serum β2‐microglobulin was >5 mg/L (5.2–13.5 mg/L) in 12 of the 13 cases with proved fetal toxoplasmosis infection, indicating 90% sensitivity. In the 39 pregnancies with maternal seroconversion but no laboratory signs of fetal infection, fetal serum β2‐microglobulin was <5 mg/L, indicating 100% specificity. Fetal serum was >5 mg/L (6.3–32 mg/L) in 14 of the 15 cases with proved fetal CMV infection, indicating 93.3% sensitivity. Specificity cannot be evaluated because maternal serum is not routinely screened for CMV during pregnancy.</p></abstract><abstract><p>Fetal serum β2‐microglobulin is a reliable marker of fetal CMV or toxoplasmosis infection, which can be used in ambiguous situations. Because this increase is not specific, fetal serum β2‐microglobulin would potentially be raised in other fetal infections. Copyright © 2006 John Wiley & Sons, Ltd.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>fetal serum β2‐microglobulin</term></item><item><term>prenatal diagnosis</term></item><item><term>fetal blood</term></item><item><term>CMV infection</term></item><item><term>toxoplasmosis infection</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Short Communication</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2005-09-19">Received</change><change when="2006-02-22">Registration</change><change when="2006-05">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/64AF04FB3FC3A8E43769BE70B33509B986B472EB/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>John Wiley & Sons, Ltd.</publisherName><publisherLoc>Chichester, UK</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1097-0223</doi><issn type="print">0197-3851</issn><issn type="electronic">1097-0223</issn><idGroup><id type="product" value="PD"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="PRENATAL DIAGNOSIS">Prenatal Diagnosis</title><title type="subtitle">Published in Affiliation With the International Society for Prenatal Diagnosis</title><title type="short">Prenat. 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type="tableTotal" number="1"></count><count type="referenceTotal" number="21"></count></countGroup><titleGroup><title type="main" xml:lang="en">Fetal serum β2‐microglobulin as a marker for fetal infectious diseases</title><title type="short" xml:lang="en">FETAL SERUM β2‐MICROGLOBULIN IN FETAL INFECTION</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Sophie</givenNames><familyName>Dreux</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Thierry</givenNames><familyName>Rousseau</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Stefan</givenNames><familyName>Gerber</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Jean‐Yves</givenNames><familyName>Col</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Marc</givenNames><familyName>Dommergues</familyName></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1 #af2" corresponding="yes"><personName><givenNames>Françoise</givenNames><familyName>Muller</familyName></personName><contactDetails><email normalForm="francoise.muller@rdb.ap-hop-paris.fr">francoise.muller@rdb.ap‐hop‐paris.fr</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="FR" type="organization"><unparsedAffiliation>Biochimie‐Hormonologie, Hôpital Robert Debré, AP‐HP, Paris, France</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="FR" type="organization"><unparsedAffiliation>Université Paris Ile de France Ouest, Paris, France</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="FR" type="organization"><unparsedAffiliation>Gynécologie‐Obstétrique, Maternité du Bocage, 21000, Dijon, France</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="CH" type="organization"><unparsedAffiliation>Gynécologie‐Obstétrique, CHUV de Lausanne, 1011 Lausanne VD, Suisse</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="FR" type="organization"><unparsedAffiliation>Gynécologie‐Obstétrique, Centre Hospitalier, Le Havre, France</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="FR" type="organization"><unparsedAffiliation>Gynécologie‐Obstétrique, Hôpital Necker, AP‐HP, Paris, France</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">fetal serum β2‐microglobulin</keyword><keyword xml:id="kwd2">prenatal diagnosis</keyword><keyword xml:id="kwd3">fetal blood</keyword><keyword xml:id="kwd4">CMV infection</keyword><keyword xml:id="kwd5">toxoplasmosis infection</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><section xml:id="abs1-1"><title type="main">Objectives</title><p>To evaluate whether fetal serum β2‐microglobulin could be used as a marker of fetal cytomegalovirus (CMV) or toxoplasmosis infection.</p></section><section xml:id="abs1-2"><title type="main">Methods</title><p>β2‐microglobulin was retrospectively assayed in fetal serum collected from 64 patients with maternal infectious seroconversion (toxoplasmosis in 49 cases, CMV in 15). Using a β2‐microglobulin cutoff of 5 mg/L, infection and control groups were compared.</p></section><section xml:id="abs1-3"><title type="main">Results</title><p>Fetal serum β2‐microglobulin was >5 mg/L (5.2–13.5 mg/L) in 12 of the 13 cases with proved fetal toxoplasmosis infection, indicating 90% sensitivity. In the 39 pregnancies with maternal seroconversion but no laboratory signs of fetal infection, fetal serum β2‐microglobulin was <5 mg/L, indicating 100% specificity. Fetal serum was >5 mg/L (6.3–32 mg/L) in 14 of the 15 cases with proved fetal CMV infection, indicating 93.3% sensitivity. Specificity cannot be evaluated because maternal serum is not routinely screened for CMV during pregnancy.</p></section><section xml:id="abs1-4"><title type="main">Conclusions</title><p>Fetal serum β2‐microglobulin is a reliable marker of fetal CMV or toxoplasmosis infection, which can be used in ambiguous situations. Because this increase is not specific, fetal serum β2‐microglobulin would potentially be raised in other fetal infections. Copyright © 2006 John Wiley & Sons, Ltd.</p></section></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Fetal serum β2‐microglobulin as a marker for fetal infectious diseases</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>FETAL SERUM β2‐MICROGLOBULIN IN FETAL INFECTION</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Fetal serum β2‐microglobulin as a marker for fetal infectious diseases</title></titleInfo><name type="personal"><namePart type="given">Sophie</namePart><namePart type="family">Dreux</namePart><affiliation>Biochimie‐Hormonologie, Hôpital Robert Debré, AP‐HP, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Thierry</namePart><namePart type="family">Rousseau</namePart><affiliation>Gynécologie‐Obstétrique, Maternité du Bocage, 21000, Dijon, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stefan</namePart><namePart type="family">Gerber</namePart><affiliation>Gynécologie‐Obstétrique, CHUV de Lausanne, 1011 Lausanne VD, Suisse</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean‐Yves</namePart><namePart type="family">Col</namePart><affiliation>Gynécologie‐Obstétrique, Centre Hospitalier, Le Havre, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marc</namePart><namePart type="family">Dommergues</namePart><affiliation>Gynécologie‐Obstétrique, Hôpital Necker, AP‐HP, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Françoise</namePart><namePart type="family">Muller</namePart><affiliation>Biochimie‐Hormonologie, Hôpital Robert Debré, AP‐HP, Paris, France</affiliation><affiliation>Université Paris Ile de France Ouest, Paris, France</affiliation><description>Correspondence: Biochimie Hormonologie, Hôpital Robert Debré, 48, Bd Sérurier, 75935 Paris Cedex 19, France.</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="brief-communication" displayLabel="shortCommunication"></genre><originInfo><publisher>John Wiley & Sons, Ltd.</publisher><place><placeTerm type="text">Chichester, UK</placeTerm></place><dateIssued encoding="w3cdtf">2006-05</dateIssued><dateCaptured encoding="w3cdtf">2005-09-19</dateCaptured><dateValid encoding="w3cdtf">2006-02-22</dateValid><copyrightDate encoding="w3cdtf">2006</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">1</extent><extent unit="references">21</extent></physicalDescription><abstract>To evaluate whether fetal serum β2‐microglobulin could be used as a marker of fetal cytomegalovirus (CMV) or toxoplasmosis infection.</abstract><abstract>β2‐microglobulin was retrospectively assayed in fetal serum collected from 64 patients with maternal infectious seroconversion (toxoplasmosis in 49 cases, CMV in 15). Using a β2‐microglobulin cutoff of 5 mg/L, infection and control groups were compared.</abstract><abstract>Fetal serum β2‐microglobulin was >5 mg/L (5.2–13.5 mg/L) in 12 of the 13 cases with proved fetal toxoplasmosis infection, indicating 90% sensitivity. In the 39 pregnancies with maternal seroconversion but no laboratory signs of fetal infection, fetal serum β2‐microglobulin was <5 mg/L, indicating 100% specificity. Fetal serum was >5 mg/L (6.3–32 mg/L) in 14 of the 15 cases with proved fetal CMV infection, indicating 93.3% sensitivity. Specificity cannot be evaluated because maternal serum is not routinely screened for CMV during pregnancy.</abstract><abstract>Fetal serum β2‐microglobulin is a reliable marker of fetal CMV or toxoplasmosis infection, which can be used in ambiguous situations. Because this increase is not specific, fetal serum β2‐microglobulin would potentially be raised in other fetal infections. Copyright © 2006 John Wiley & Sons, Ltd.</abstract><subject lang="en"><genre>keywords</genre><topic>fetal serum β2‐microglobulin</topic><topic>prenatal diagnosis</topic><topic>fetal blood</topic><topic>CMV infection</topic><topic>toxoplasmosis infection</topic></subject><relatedItem type="host"><titleInfo><title>Prenatal Diagnosis</title><subTitle>Published in Affiliation With the International Society for Prenatal Diagnosis</subTitle></titleInfo><titleInfo type="abbreviated"><title>Prenat. Diagn.</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Short Communication</topic></subject><identifier type="ISSN">0197-3851</identifier><identifier type="eISSN">1097-0223</identifier><identifier type="DOI">10.1002/(ISSN)1097-0223</identifier><identifier type="PublisherID">PD</identifier><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>471</start><end>474</end><total>4</total></extent></part></relatedItem><identifier type="istex">64AF04FB3FC3A8E43769BE70B33509B986B472EB</identifier><identifier type="DOI">10.1002/pd.1441</identifier><identifier type="ArticleID">PD1441</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2006 John Wiley & Sons, Ltd.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>John Wiley & Sons, Ltd.</recordOrigin></recordInfo></mods></metadata><enrichments><json:item><type>multicat</type><uri>https://api.istex.fr/document/64AF04FB3FC3A8E43769BE70B33509B986B472EB/enrichments/multicat</uri></json:item></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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