Cough after inhalation of corticosteroids delivered from spacer devices in children with asthma
Identifieur interne : 000588 ( Istex/Corpus ); précédent : 000587; suivant : 000589Cough after inhalation of corticosteroids delivered from spacer devices in children with asthma
Auteurs : Jean-Christophe Dubus ; Laurent Mély ; Laetitia Huiart ; Christophe Marguet ; Pascal Le RouxSource :
- Fundamental & Clinical Pharmacology [ 0767-3981 ] ; 2003-10.
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Abstract
Children using a spacer device rather than another device for delivering inhaled corticosteroids (ICS) has been identified as a risk factor for cough immediately after inhalation. The aim of this study was to point out the different factors influencing the occurrence of such lateral side‐effects. We studied this local side‐effect in 402 asthmatic children (55.6 ± 34.9 months; 65.6% boys) treated for at least 1 month with beclomethasone dipropionate (n = 331), budesonide (n = 47) or fluticasone propionate (n = 24) delivered from pressurized metered‐dose inhalers and small (75.1%) or large volume (24.8%) spacer devices mainly used with face mask (90.7%). A total of 219 patients (54.5%), treated with either high doses of ICS or ICS and long‐acting β2‐agonist, were considered as having severe asthma. Cough was reported after each inhalation of corticosteroids in 216 patients (53.7%). Among them, about 30% also complained of cough with β2‐agonists. Despite different propellants and dispersants, all corticosteroids induced cough similarly. Cough was not linked with asthma severity, but was significantly related to therapy duration and use of long‐acting β2‐agonist. Type and volume of the spacer device, use of a face mask or mouthpiece were not influencing factors. Cough after inhalation of corticosteroids delivered from spacer devices is a frequent local side‐effect in children with asthma. This side effect can greatly alter compliance. A practitioner must be sought at each visit.
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DOI: 10.1046/j.1472-8206.2003.00191.x
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ISTEX:04FCC1E2283F1B86F11B3C7AFA5B86CC98AE2725Le document en format XML
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The aim of this study was to point out the different factors influencing the occurrence of such lateral side‐effects. We studied this local side‐effect in 402 asthmatic children (55.6 ± 34.9 months; 65.6% boys) treated for at least 1 month with beclomethasone dipropionate (n = 331), budesonide (n = 47) or fluticasone propionate (n = 24) delivered from pressurized metered‐dose inhalers and small (75.1%) or large volume (24.8%) spacer devices mainly used with face mask (90.7%). A total of 219 patients (54.5%), treated with either high doses of ICS or ICS and long‐acting β2‐agonist, were considered as having severe asthma. Cough was reported after each inhalation of corticosteroids in 216 patients (53.7%). Among them, about 30% also complained of cough with β2‐agonists. Despite different propellants and dispersants, all corticosteroids induced cough similarly. Cough was not linked with asthma severity, but was significantly related to therapy duration and use of long‐acting β2‐agonist. Type and volume of the spacer device, use of a face mask or mouthpiece were not influencing factors. Cough after inhalation of corticosteroids delivered from spacer devices is a frequent local side‐effect in children with asthma. This side effect can greatly alter compliance. 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The aim of this study was to point out the different factors influencing the occurrence of such lateral side‐effects. We studied this local side‐effect in 402 asthmatic children (55.6 ± 34.9 months; 65.6% boys) treated for at least 1 month with beclomethasone dipropionate (n = 331), budesonide (n = 47) or fluticasone propionate (n = 24) delivered from pressurized metered‐dose inhalers and small (75.1%) or large volume (24.8%) spacer devices mainly used with face mask (90.7%). A total of 219 patients (54.5%), treated with either high doses of ICS or ICS and long‐acting β2‐agonist, were considered as having severe asthma. Cough was reported after each inhalation of corticosteroids in 216 patients (53.7%). Among them, about 30% also complained of cough with β2‐agonists. Despite different propellants and dispersants, all corticosteroids induced cough similarly. Cough was not linked with asthma severity, but was significantly related to therapy duration and use of long‐acting β2‐agonist. Type and volume of the spacer device, use of a face mask or mouthpiece were not influencing factors. Cough after inhalation of corticosteroids delivered from spacer devices is a frequent local side‐effect in children with asthma. This side effect can greatly alter compliance. A practitioner must be sought at each visit.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>asthma</term></item><item><term>corticosteroids</term></item><item><term>cough</term></item><item><term>inhaled therapy</term></item><item><term>spacer device</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2003-10">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/04FCC1E2283F1B86F11B3C7AFA5B86CC98AE2725/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Science Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1472-8206</doi><issn type="print">0767-3981</issn><issn type="electronic">1472-8206</issn><idGroup><id type="product" value="FCP"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="FUNDAMENTAL CLINICAL PHARMACOLOGY">Fundamental & Clinical Pharmacology</title></titleGroup></publicationMeta><publicationMeta level="part" position="10005"><doi origin="wiley">10.1111/fcp.2003.17.issue-5</doi><numberingGroup><numbering type="journalVolume" number="17">17</numbering><numbering type="journalIssue" number="5">5</numbering></numberingGroup><coverDate startDate="2003-10">October 2003</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="0062700" status="forIssue"><doi origin="wiley">10.1046/j.1472-8206.2003.00191.x</doi><idGroup><id type="unit" value="FCP191"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><titleGroup><title type="tocHeading1">Clinical Pharmacology</title></titleGroup><eventGroup><event type="firstOnline" date="2003-09-18"></event><event type="publishedOnlineFinalForm" date="2003-09-18"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-06"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-12"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-16"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="627">627</numbering><numbering type="pageLast" number="631">631</numbering></numberingGroup><correspondenceTo> * <email normalForm="jean-christophe.dubus@ap-hm.fr">jean‐christophe.dubus@ap‐hm.fr</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:FCP.FCP191.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 19 September 2002; revised 17 February 2003; accepted 5 May 2003</unparsedEditorialHistory><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="0"></count></countGroup><titleGroup><title type="main">Cough after inhalation of corticosteroids delivered from spacer devices in children with asthma</title><title type="shortAuthors">J.‐C. Dubus <i>et al</i>.</title><title type="short"><i>Inhaled corticosteroid‐induced cough</i></title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" corresponding="yes"><personName><givenNames>Jean‐Christophe</givenNames><familyName>Dubus</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>Laurent</givenNames><familyName>Mély</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a2"><personName><givenNames>Laetitia</givenNames><familyName>Huiart</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a3"><personName><givenNames>Christophe</givenNames><familyName>Marguet</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a4"><personName><givenNames>Pascal Le</givenNames><familyName>Roux</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a1"><groupName>on behalf of the ‘Réseau de Recherche Clinique en Pneumologie Pédiatrique’</groupName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="FR"><unparsedAffiliation>Department of Pediatrics, Timone Children's University Hospital, Boulevard Jean Moulin, 13385 Marseille, France</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="FR"><unparsedAffiliation>Medical Informatics Department, Sainte‐Marguerite University Hospital, Boulevard de Saint‐Marguerite, 13009 Marseille, France</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="FR"><unparsedAffiliation>Department of Pediatrics, Charles Nicolle University Hospital, Rue de germont, 76031 Rouen, France</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="FR"><unparsedAffiliation>Department of Pediatrics, Le Havre Hospital, Avenue Gustave Flaubert, 76083 Le Havre, France</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">asthma</keyword><keyword xml:id="k2">corticosteroids</keyword><keyword xml:id="k3">cough</keyword><keyword xml:id="k4">inhaled therapy</keyword><keyword xml:id="k5">spacer device</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Children using a spacer device rather than another device for delivering inhaled corticosteroids (ICS) has been identified as a risk factor for cough immediately after inhalation. The aim of this study was to point out the different factors influencing the occurrence of such lateral side‐effects. We studied this local side‐effect in 402 asthmatic children (55.6 ± 34.9 months; 65.6% boys) treated for at least 1 month with beclomethasone dipropionate (<i>n</i> = 331), budesonide (<i>n</i> = 47) or fluticasone propionate (<i>n</i> = 24) delivered from pressurized metered‐dose inhalers and small (75.1%) or large volume (24.8%) spacer devices mainly used with face mask (90.7%). A total of 219 patients (54.5%), treated with either high doses of ICS or ICS and long‐acting <i>β</i>2‐agonist, were considered as having severe asthma. Cough was reported after each inhalation of corticosteroids in 216 patients (53.7%). Among them, about 30% also complained of cough with <i>β</i>2‐agonists. Despite different propellants and dispersants, all corticosteroids induced cough similarly. Cough was not linked with asthma severity, but was significantly related to therapy duration and use of long‐acting <i>β</i>2‐agonist. Type and volume of the spacer device, use of a face mask or mouthpiece were not influencing factors. Cough after inhalation of corticosteroids delivered from spacer devices is a frequent local side‐effect in children with asthma. This side effect can greatly alter compliance. A practitioner must be sought at each visit.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Cough after inhalation of corticosteroids delivered from spacer devices in children with asthma</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Inhaled corticosteroid‐induced cough</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Cough after inhalation of corticosteroids delivered from spacer devices in children with asthma</title></titleInfo><name type="personal"><namePart type="given">Jean‐Christophe</namePart><namePart type="family">Dubus</namePart><affiliation>Department of Pediatrics, Timone Children's University Hospital, Boulevard Jean Moulin, 13385 Marseille, France</affiliation><description>Correspondence: *</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Laurent</namePart><namePart type="family">Mély</namePart><affiliation>Department of Pediatrics, Timone Children's University Hospital, Boulevard Jean Moulin, 13385 Marseille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Laetitia</namePart><namePart type="family">Huiart</namePart><affiliation>Medical Informatics Department, Sainte‐Marguerite University Hospital, Boulevard de Saint‐Marguerite, 13009 Marseille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christophe</namePart><namePart type="family">Marguet</namePart><affiliation>Department of Pediatrics, Charles Nicolle University Hospital, Rue de germont, 76031 Rouen, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pascal Le</namePart><namePart type="family">Roux</namePart><affiliation>Department of Pediatrics, Le Havre Hospital, Avenue Gustave Flaubert, 76083 Le Havre, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="corporate"><namePart>on behalf of the ‘Réseau de Recherche Clinique en Pneumologie Pédiatrique’</namePart><description>Department of Pediatrics, Timone Children's University Hospital, Boulevard Jean Moulin, 13385 Marseille, FranceMedical Informatics Department, Sainte‐Marguerite University Hospital, Boulevard de Saint‐Marguerite, 13009 Marseille, FranceDepartment of Pediatrics, Charles Nicolle University Hospital, Rue de germont, 76031 Rouen, FranceDepartment of Pediatrics, Le Havre Hospital, Avenue Gustave Flaubert, 76083 Le Havre, France</description></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Science Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2003-10</dateIssued><edition>Received 19 September 2002; revised 17 February 2003; accepted 5 May 2003</edition><copyrightDate encoding="w3cdtf">2003</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Children using a spacer device rather than another device for delivering inhaled corticosteroids (ICS) has been identified as a risk factor for cough immediately after inhalation. The aim of this study was to point out the different factors influencing the occurrence of such lateral side‐effects. We studied this local side‐effect in 402 asthmatic children (55.6 ± 34.9 months; 65.6% boys) treated for at least 1 month with beclomethasone dipropionate (n = 331), budesonide (n = 47) or fluticasone propionate (n = 24) delivered from pressurized metered‐dose inhalers and small (75.1%) or large volume (24.8%) spacer devices mainly used with face mask (90.7%). A total of 219 patients (54.5%), treated with either high doses of ICS or ICS and long‐acting β2‐agonist, were considered as having severe asthma. Cough was reported after each inhalation of corticosteroids in 216 patients (53.7%). Among them, about 30% also complained of cough with β2‐agonists. Despite different propellants and dispersants, all corticosteroids induced cough similarly. Cough was not linked with asthma severity, but was significantly related to therapy duration and use of long‐acting β2‐agonist. Type and volume of the spacer device, use of a face mask or mouthpiece were not influencing factors. Cough after inhalation of corticosteroids delivered from spacer devices is a frequent local side‐effect in children with asthma. This side effect can greatly alter compliance. A practitioner must be sought at each visit.</abstract><subject lang="en"><genre>keywords</genre><topic>asthma</topic><topic>corticosteroids</topic><topic>cough</topic><topic>inhaled therapy</topic><topic>spacer device</topic></subject><relatedItem type="host"><titleInfo><title>Fundamental & Clinical Pharmacology</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0767-3981</identifier><identifier type="eISSN">1472-8206</identifier><identifier type="DOI">10.1111/(ISSN)1472-8206</identifier><identifier type="PublisherID">FCP</identifier><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>627</start><end>631</end><total>5</total></extent></part></relatedItem><identifier type="istex">04FCC1E2283F1B86F11B3C7AFA5B86CC98AE2725</identifier><identifier type="DOI">10.1046/j.1472-8206.2003.00191.x</identifier><identifier type="ArticleID">FCP191</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Science Ltd</recordOrigin></recordInfo></mods></metadata><enrichments><json:item><type>multicat</type><uri>https://api.istex.fr/document/04FCC1E2283F1B86F11B3C7AFA5B86CC98AE2725/enrichments/multicat</uri></json:item></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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