Application of Inductively Coupled Plasma Mass Spectrometry Multielement Analysis in Fingernail and Toenail as a Biomarker of Metal Exposure
Identifieur interne : 000574 ( Istex/Corpus ); précédent : 000573; suivant : 000575Application of Inductively Coupled Plasma Mass Spectrometry Multielement Analysis in Fingernail and Toenail as a Biomarker of Metal Exposure
Auteurs : J. P. Goullé ; E. Saussereau ; L. Mahieu ; D. Bouige ; S. Groenwont ; M. Guerbet ; C. LacroixSource :
- Journal of Analytical Toxicology [ 0146-4760 ] ; 2009-03.
Abstract
The application of inductively coupled plasma mass spectrometry (ICP-MS) to multielement analysis in fingernail and toenail as biological indices for metal exposure is presented. The ICP-MS measurements were performed using a Thermo Elemental X7CCT series. Fingernail specimens were obtained from 130 healthy volunteers, and paired fingernail and toenail samples from 50 additional healthy volunteers of both sexes were collected as well. After warm water and acetone decontamination, 20 mg fingernails and toenails were acid mineralized after a decontamination procedure, and 32–34 elements were simultaneously quantified after acid dilution following water calibration. Li, Be, B, Al, V, Cr, Mn, Co, Ni, Cu, Zn, Ga, Ge, As, Se, Rb, Sr, Mo, Pd, Ag, Cd, Sn, Sb, Te, Ba, La, Gd, W, Pt, Hg, Tl, Pb, Bi, and U could be validated in fingernail and toenail samples. Linearity was excellent, and the correlation coefficients were above 0.999. Quantification limits ranged from 0.04 pg/mg or ng/g (U) to 0.1 ng/mg or µg/g (B). Because of the lack of available certified nail reference material, an adequate quality assessment scheme was ensured by comparison with an interlaboratory nail-testing procedure, and the results showed optimal consistency for elements tested. Results are presented and compared with published multielement data. Six cases of domestic exposure to lead were diagnosed based on fingernail analysis. Application of ICP-MS multielement analysis in fingernail and toenail as a biomarker of metal and nonmetal exposure permits greater noninvasive control of industrial, domestic, or environmental exposure and is very useful for epidemiological studies.
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DOI: 10.1093/jat/33.2.92
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Mahieu</name><affiliation><mods:affiliation>Laboratoire de Toxicologie, Groupe Hospitalier, BP 24, 76083 Le Havre, France</mods:affiliation></affiliation></author><author><name sortKey="Bouige, D" sort="Bouige, D" uniqKey="Bouige D" first="D." last="Bouige">D. Bouige</name><affiliation><mods:affiliation>Laboratoire de Biochimie, Groupe Hospitalier, BP 24, 76083 Le Havre, France</mods:affiliation></affiliation></author><author><name sortKey="Groenwont, S" sort="Groenwont, S" uniqKey="Groenwont S" first="S." last="Groenwont">S. Groenwont</name><affiliation><mods:affiliation>Laboratoire de Toxicologie, Groupe Hospitalier, BP 24, 76083 Le Havre, France</mods:affiliation></affiliation></author><author><name sortKey="Guerbet, M" sort="Guerbet, M" uniqKey="Guerbet M" first="M." last="Guerbet">M. 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The ICP-MS measurements were performed using a Thermo Elemental X7CCT series. Fingernail specimens were obtained from 130 healthy volunteers, and paired fingernail and toenail samples from 50 additional healthy volunteers of both sexes were collected as well. After warm water and acetone decontamination, 20 mg fingernails and toenails were acid mineralized after a decontamination procedure, and 32–34 elements were simultaneously quantified after acid dilution following water calibration. Li, Be, B, Al, V, Cr, Mn, Co, Ni, Cu, Zn, Ga, Ge, As, Se, Rb, Sr, Mo, Pd, Ag, Cd, Sn, Sb, Te, Ba, La, Gd, W, Pt, Hg, Tl, Pb, Bi, and U could be validated in fingernail and toenail samples. Linearity was excellent, and the correlation coefficients were above 0.999. Quantification limits ranged from 0.04 pg/mg or ng/g (U) to 0.1 ng/mg or µg/g (B). Because of the lack of available certified nail reference material, an adequate quality assessment scheme was ensured by comparison with an interlaboratory nail-testing procedure, and the results showed optimal consistency for elements tested. Results are presented and compared with published multielement data. Six cases of domestic exposure to lead were diagnosed based on fingernail analysis. Application of ICP-MS multielement analysis in fingernail and toenail as a biomarker of metal and nonmetal exposure permits greater noninvasive control of industrial, domestic, or environmental exposure and is very useful for epidemiological studies.</div></front></TEI><istex><corpusName>oup</corpusName><author><json:item><name>J.P. 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Fingernail specimens were obtained from 130 healthy volunteers, and paired fingernail and toenail samples from 50 additional healthy volunteers of both sexes were collected as well. After warm water and acetone decontamination, 20 mg fingernails and toenails were acid mineralized after a decontamination procedure, and 32–34 elements were simultaneously quantified after acid dilution following water calibration. Li, Be, B, Al, V, Cr, Mn, Co, Ni, Cu, Zn, Ga, Ge, As, Se, Rb, Sr, Mo, Pd, Ag, Cd, Sn, Sb, Te, Ba, La, Gd, W, Pt, Hg, Tl, Pb, Bi, and U could be validated in fingernail and toenail samples. Linearity was excellent, and the correlation coefficients were above 0.999. Quantification limits ranged from 0.04 pg/mg or ng/g (U) to 0.1 ng/mg or µg/g (B). Because of the lack of available certified nail reference material, an adequate quality assessment scheme was ensured by comparison with an interlaboratory nail-testing procedure, and the results showed optimal consistency for elements tested. Results are presented and compared with published multielement data. Six cases of domestic exposure to lead were diagnosed based on fingernail analysis. 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bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Oxford University Press</publisher><availability><p>OUP</p></availability><date>2009</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Application of Inductively Coupled Plasma Mass Spectrometry Multielement Analysis in Fingernail and Toenail as a Biomarker of Metal Exposure</title><author xml:id="author-1" corresp="yes"><persName><forename type="first">J.P.</forename><surname>Goullé</surname></persName><email>jgoulle@ch-havre.fr</email><affiliation>Laboratoire de Toxicologie, Groupe Hospitalier, BP 24, 76083 Le Havre, France</affiliation><affiliation>Laboratoire de Toxicologie, Faculté de Médecine et de Pharmacie, 22 boulevard Gambetta, 76183 Rouen, France</affiliation></author><author xml:id="author-2"><persName><forename type="first">E.</forename><surname>Saussereau</surname></persName><affiliation>Laboratoire de Toxicologie, Groupe Hospitalier, BP 24, 76083 Le Havre, France</affiliation></author><author xml:id="author-3"><persName><forename type="first">L.</forename><surname>Mahieu</surname></persName><affiliation>Laboratoire de Toxicologie, Groupe Hospitalier, BP 24, 76083 Le Havre, France</affiliation></author><author xml:id="author-4"><persName><forename type="first">D.</forename><surname>Bouige</surname></persName><affiliation>Laboratoire de Biochimie, Groupe Hospitalier, BP 24, 76083 Le Havre, France</affiliation></author><author xml:id="author-5"><persName><forename type="first">S.</forename><surname>Groenwont</surname></persName><affiliation>Laboratoire de Toxicologie, Groupe Hospitalier, BP 24, 76083 Le Havre, France</affiliation></author><author xml:id="author-6"><persName><forename type="first">M.</forename><surname>Guerbet</surname></persName><affiliation>Laboratoire de Toxicologie, Faculté de Médecine et de Pharmacie, 22 boulevard Gambetta, 76183 Rouen, France</affiliation></author><author xml:id="author-7"><persName><forename type="first">C.</forename><surname>Lacroix</surname></persName><affiliation>Laboratoire de Toxicologie, Groupe Hospitalier, BP 24, 76083 Le Havre, France</affiliation></author></analytic><monogr><title level="j">Journal of Analytical Toxicology</title><title level="j" type="abbrev">Journal of Analytical Toxicology</title><idno type="pISSN">0146-4760</idno><idno type="eISSN">1945-2403</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2009-03"></date><biblScope unit="volume">33</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="92">92</biblScope><biblScope unit="page" to="98">98</biblScope></imprint></monogr><idno type="istex">B704A26676B8C80438FB817D7D477F5394B7BAC2</idno><idno type="DOI">10.1093/jat/33.2.92</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2009</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>The application of inductively coupled plasma mass spectrometry (ICP-MS) to multielement analysis in fingernail and toenail as biological indices for metal exposure is presented. The ICP-MS measurements were performed using a Thermo Elemental X7CCT series. Fingernail specimens were obtained from 130 healthy volunteers, and paired fingernail and toenail samples from 50 additional healthy volunteers of both sexes were collected as well. After warm water and acetone decontamination, 20 mg fingernails and toenails were acid mineralized after a decontamination procedure, and 32–34 elements were simultaneously quantified after acid dilution following water calibration. Li, Be, B, Al, V, Cr, Mn, Co, Ni, Cu, Zn, Ga, Ge, As, Se, Rb, Sr, Mo, Pd, Ag, Cd, Sn, Sb, Te, Ba, La, Gd, W, Pt, Hg, Tl, Pb, Bi, and U could be validated in fingernail and toenail samples. Linearity was excellent, and the correlation coefficients were above 0.999. Quantification limits ranged from 0.04 pg/mg or ng/g (U) to 0.1 ng/mg or µg/g (B). Because of the lack of available certified nail reference material, an adequate quality assessment scheme was ensured by comparison with an interlaboratory nail-testing procedure, and the results showed optimal consistency for elements tested. Results are presented and compared with published multielement data. Six cases of domestic exposure to lead were diagnosed based on fingernail analysis. Application of ICP-MS multielement analysis in fingernail and toenail as a biomarker of metal and nonmetal exposure permits greater noninvasive control of industrial, domestic, or environmental exposure and is very useful for epidemiological studies.</p></abstract></profileDesc><revisionDesc><change when="2009-03">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-10-14">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/B704A26676B8C80438FB817D7D477F5394B7BAC2/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus oup" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article"><front><journal-meta><journal-id journal-id-type="hwp">jat</journal-id><journal-id journal-id-type="publisher-id">jat</journal-id><journal-title>Journal of Analytical Toxicology</journal-title><abbrev-journal-title>Journal of Analytical Toxicology</abbrev-journal-title><issn pub-type="ppub">0146-4760</issn><issn pub-type="epub">1945-2403</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.1093/jat/33.2.92</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Application of Inductively Coupled Plasma Mass Spectrometry Multielement Analysis in Fingernail and Toenail as a Biomarker of Metal Exposure<xref ref-type="fn" rid="FN1">*</xref></article-title><fn-group><fn fn-type="presented-at" id="FN1"><label>*</label><p>This work was partially presented at the 43rd TIAFT Meeting in Seattle, WA, August 26–30, 2007.</p></fn></fn-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Goullé</surname><given-names>J.P.</given-names></name><xref ref-type="aff" rid="AU1">1</xref><xref ref-type="aff" rid="AU2">2</xref><xref ref-type="corresp" rid="COR1">†</xref></contrib><contrib contrib-type="author"><name><surname>Saussereau</surname><given-names>E.</given-names></name><xref ref-type="aff" rid="AU1">1</xref></contrib><contrib contrib-type="author"><name><surname>Mahieu</surname><given-names>L.</given-names></name><xref ref-type="aff" rid="AU1">1</xref></contrib><contrib contrib-type="author"><name><surname>Bouige</surname><given-names>D.</given-names></name><xref ref-type="aff" rid="AU3">3</xref></contrib><contrib contrib-type="author"><name><surname>Groenwont</surname><given-names>S.</given-names></name><xref ref-type="aff" rid="AU1">1</xref></contrib><contrib contrib-type="author"><name><surname>Guerbet</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="AU2">2</xref></contrib><contrib contrib-type="author"><name><surname>Lacroix</surname><given-names>C.</given-names></name><xref ref-type="aff" rid="AU1">1</xref></contrib><aff id="AU1"><label>1</label><institution>Laboratoire de Toxicologie, Groupe Hospitalier</institution>, <addr-line>BP 24, 76083 Le Havre, France</addr-line></aff><aff id="AU2"><label>2</label><institution>Laboratoire de Toxicologie, Faculté de Médecine et de Pharmacie</institution>, <addr-line>22 boulevard Gambetta, 76183 Rouen, France</addr-line></aff><aff id="AU3"><label>3</label><institution>Laboratoire de Biochimie, Groupe Hospitalier</institution>, <addr-line>BP 24, 76083 Le Havre, France</addr-line></aff></contrib-group><author-notes><corresp id="COR1"><label>†</label> Author to whom correspondence and reprint requests should be addressed: Professor Jean-Pierre Goullé, Laboratoire de pharmacocinétique et de toxicologie cliniques, Groupe Hospitalier Jacques Monod, BP 24, 76083 Le Havre-Cedex, France. E-mail: <email>jgoulle@ch-havre.fr</email>.</corresp></author-notes><pub-date pub-type="ppub"><month>3</month><year>2009</year></pub-date><volume>33</volume><issue>2</issue><fpage>92</fpage><lpage>98</lpage><history><date date-type="received"><day>1</day><month>4</month><year>2008</year></date><date date-type="rev-recd"><day>28</day><month>4</month><year>2008</year></date></history><copyright-year>2009</copyright-year><abstract><p>The application of inductively coupled plasma mass spectrometry (ICP-MS) to multielement analysis in fingernail and toenail as biological indices for metal exposure is presented. The ICP-MS measurements were performed using a Thermo Elemental X7CCT series. Fingernail specimens were obtained from 130 healthy volunteers, and paired fingernail and toenail samples from 50 additional healthy volunteers of both sexes were collected as well. After warm water and acetone decontamination, 20 mg fingernails and toenails were acid mineralized after a decontamination procedure, and 32–34 elements were simultaneously quantified after acid dilution following water calibration. Li, Be, B, Al, V, Cr, Mn, Co, Ni, Cu, Zn, Ga, Ge, As, Se, Rb, Sr, Mo, Pd, Ag, Cd, Sn, Sb, Te, Ba, La, Gd, W, Pt, Hg, Tl, Pb, Bi, and U could be validated in fingernail and toenail samples. Linearity was excellent, and the correlation coefficients were above 0.999. Quantification limits ranged from 0.04 pg/mg or ng/g (U) to 0.1 ng/mg or µg/g (B). Because of the lack of available certified nail reference material, an adequate quality assessment scheme was ensured by comparison with an interlaboratory nail-testing procedure, and the results showed optimal consistency for elements tested. Results are presented and compared with published multielement data. Six cases of domestic exposure to lead were diagnosed based on fingernail analysis. Application of ICP-MS multielement analysis in fingernail and toenail as a biomarker of metal and nonmetal exposure permits greater noninvasive control of industrial, domestic, or environmental exposure and is very useful for epidemiological studies.</p></abstract></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Application of Inductively Coupled Plasma Mass Spectrometry Multielement Analysis in Fingernail and Toenail as a Biomarker of Metal Exposure</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Application of Inductively Coupled Plasma Mass Spectrometry Multielement Analysis in Fingernail and Toenail as a Biomarker of Metal Exposure*</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">J.P.</namePart><namePart type="family">Goullé</namePart><affiliation>Laboratoire de Toxicologie, Groupe Hospitalier, BP 24, 76083 Le Havre, France</affiliation><affiliation>Laboratoire de Toxicologie, Faculté de Médecine et de Pharmacie, 22 boulevard Gambetta, 76183 Rouen, France</affiliation><affiliation>E-mail: jgoulle@ch-havre.fr</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Saussereau</namePart><affiliation>Laboratoire de Toxicologie, Groupe Hospitalier, BP 24, 76083 Le Havre, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Mahieu</namePart><affiliation>Laboratoire de Toxicologie, Groupe Hospitalier, BP 24, 76083 Le Havre, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Bouige</namePart><affiliation>Laboratoire de Biochimie, Groupe Hospitalier, BP 24, 76083 Le Havre, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Groenwont</namePart><affiliation>Laboratoire de Toxicologie, Groupe Hospitalier, BP 24, 76083 Le Havre, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Guerbet</namePart><affiliation>Laboratoire de Toxicologie, Faculté de Médecine et de Pharmacie, 22 boulevard Gambetta, 76183 Rouen, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Lacroix</namePart><affiliation>Laboratoire de Toxicologie, Groupe Hospitalier, BP 24, 76083 Le Havre, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><originInfo><publisher>Oxford University Press</publisher><dateIssued encoding="w3cdtf">2009-03</dateIssued><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>The application of inductively coupled plasma mass spectrometry (ICP-MS) to multielement analysis in fingernail and toenail as biological indices for metal exposure is presented. The ICP-MS measurements were performed using a Thermo Elemental X7CCT series. Fingernail specimens were obtained from 130 healthy volunteers, and paired fingernail and toenail samples from 50 additional healthy volunteers of both sexes were collected as well. After warm water and acetone decontamination, 20 mg fingernails and toenails were acid mineralized after a decontamination procedure, and 32–34 elements were simultaneously quantified after acid dilution following water calibration. Li, Be, B, Al, V, Cr, Mn, Co, Ni, Cu, Zn, Ga, Ge, As, Se, Rb, Sr, Mo, Pd, Ag, Cd, Sn, Sb, Te, Ba, La, Gd, W, Pt, Hg, Tl, Pb, Bi, and U could be validated in fingernail and toenail samples. Linearity was excellent, and the correlation coefficients were above 0.999. Quantification limits ranged from 0.04 pg/mg or ng/g (U) to 0.1 ng/mg or µg/g (B). Because of the lack of available certified nail reference material, an adequate quality assessment scheme was ensured by comparison with an interlaboratory nail-testing procedure, and the results showed optimal consistency for elements tested. Results are presented and compared with published multielement data. Six cases of domestic exposure to lead were diagnosed based on fingernail analysis. Application of ICP-MS multielement analysis in fingernail and toenail as a biomarker of metal and nonmetal exposure permits greater noninvasive control of industrial, domestic, or environmental exposure and is very useful for epidemiological studies.</abstract><relatedItem type="host"><titleInfo><title>Journal of Analytical Toxicology</title></titleInfo><titleInfo type="abbreviated"><title>Journal of Analytical Toxicology</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0146-4760</identifier><identifier type="eISSN">1945-2403</identifier><identifier type="PublisherID">jat</identifier><identifier type="PublisherID-hwp">jat</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>33</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>92</start><end>98</end></extent></part></relatedItem><identifier type="istex">B704A26676B8C80438FB817D7D477F5394B7BAC2</identifier><identifier type="DOI">10.1093/jat/33.2.92</identifier><recordInfo><recordContentSource>OUP</recordContentSource></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/B704A26676B8C80438FB817D7D477F5394B7BAC2/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">TOXICOLOGY</classCode><classCode scheme="WOS">TRANSPLANTATION</classCode><classCode scheme="WOS">CHEMISTRY, ANALYTICAL</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI><json:item><type>refBibs</type><uri>https://api.istex.fr/document/B704A26676B8C80438FB817D7D477F5394B7BAC2/enrichments/refBibs</uri></json:item></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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