Méningites à répétition et déficit en facteurs du complément
Identifieur interne : 000215 ( Istex/Corpus ); précédent : 000214; suivant : 000216Méningites à répétition et déficit en facteurs du complément
Auteurs : B. Le Luyer ; M. Blondet ; P. Le Roux ; J. Boulloche ; M. T. BriquetSource :
- Medecine et Maladies Infectieuses [ 0399-077X ] ; 1995.
English descriptors
Abstract
Resume: La possibilité d'un déficit en composant du complément doit être évoquée devant la survenue de méningite à répétition. Nous rapportons deux observations révélatrices, l'une d'un déficit en C2, l'autre en C5. La survenue d'une récidive de méningite doit faire rechercher une bréche méningée (surtout s'il s'agit d'une méningite à pneumocoque), une asplénie, un déficit en immunoglobuline et un déficit du système complémentaire. Dans ce cadre, il s'agit de la voie principale (C1, C2, C4) dans 12 %, de la voie alterne dans 42 %, de la voie terminale (C5 à C9) dans 46 %. Devant l'absence de traitement spécifique de ces déficits, une prophylaxie des infections est réalisée par la pénicilline V, et par les vaccinations (pneumo 23, méningocoque A C, Haemophilus influenzae).
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DOI: 10.1016/S0399-077X(05)81689-0
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ISTEX:D1F86DCE91240D3BB02FE9E88A482B196CA80068Le document en format XML
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Le Roux</name><affiliation><mods:affiliation>Départment de Pédiatrie, CH Le Havre, 55 bis rue Gustave Flaubert - F-76600 Le Havre, France</mods:affiliation></affiliation></author><author><name sortKey="Boulloche, J" sort="Boulloche, J" uniqKey="Boulloche J" first="J." last="Boulloche">J. Boulloche</name><affiliation><mods:affiliation>Départment de Pédiatrie, CH Le Havre, 55 bis rue Gustave Flaubert - F-76600 Le Havre, France</mods:affiliation></affiliation></author><author><name sortKey="Briquet, M T" sort="Briquet, M T" uniqKey="Briquet M" first="M. T." last="Briquet">M. T. Briquet</name><affiliation><mods:affiliation>Départment de Pédiatrie, CH Le Havre, 55 bis rue Gustave Flaubert - F-76600 Le Havre, France</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D1F86DCE91240D3BB02FE9E88A482B196CA80068</idno><date when="1995" year="1995">1995</date><idno type="doi">10.1016/S0399-077X(05)81689-0</idno><idno type="url">https://api.istex.fr/document/D1F86DCE91240D3BB02FE9E88A482B196CA80068/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000215</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="fr">Méningites à répétition et déficit en facteurs du complément</title><author><name sortKey="Le Luyer, B" sort="Le Luyer, B" uniqKey="Le Luyer B" first="B." last="Le Luyer">B. Le Luyer</name><affiliation><mods:affiliation>Départment de Pédiatrie, CH Le Havre, 55 bis rue Gustave Flaubert - F-76600 Le Havre, France</mods:affiliation></affiliation></author><author><name sortKey="Blondet, M" sort="Blondet, M" uniqKey="Blondet M" first="M." last="Blondet">M. Blondet</name><affiliation><mods:affiliation>Départment de Pédiatrie, CH Le Havre, 55 bis rue Gustave Flaubert - F-76600 Le Havre, France</mods:affiliation></affiliation></author><author><name sortKey="Le Roux, P" sort="Le Roux, P" uniqKey="Le Roux P" first="P." last="Le Roux">P. Le Roux</name><affiliation><mods:affiliation>Départment de Pédiatrie, CH Le Havre, 55 bis rue Gustave Flaubert - F-76600 Le Havre, France</mods:affiliation></affiliation></author><author><name sortKey="Boulloche, J" sort="Boulloche, J" uniqKey="Boulloche J" first="J." last="Boulloche">J. Boulloche</name><affiliation><mods:affiliation>Départment de Pédiatrie, CH Le Havre, 55 bis rue Gustave Flaubert - F-76600 Le Havre, France</mods:affiliation></affiliation></author><author><name sortKey="Briquet, M T" sort="Briquet, M T" uniqKey="Briquet M" first="M. T." last="Briquet">M. T. Briquet</name><affiliation><mods:affiliation>Départment de Pédiatrie, CH Le Havre, 55 bis rue Gustave Flaubert - F-76600 Le Havre, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Medecine et Maladies Infectieuses</title><title level="j" type="abbrev">MEDMAL</title><idno type="ISSN">0399-077X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1995">1995</date><biblScope unit="volume">25</biblScope><biblScope unit="supplement">S3</biblScope><biblScope unit="page" from="1313">1313</biblScope><biblScope unit="page" to="1317">1317</biblScope></imprint><idno type="ISSN">0399-077X</idno></series><idno type="istex">D1F86DCE91240D3BB02FE9E88A482B196CA80068</idno><idno type="DOI">10.1016/S0399-077X(05)81689-0</idno><idno type="PII">S0399-077X(05)81689-0</idno><idno type="ArticleID">05816890</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0399-077X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Complement deficiency</term><term>Pneumococcus</term><term>Recurrent meningitis</term></keywords></textClass><langUsage><language ident="fr">fr</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="fr">Resume: La possibilité d'un déficit en composant du complément doit être évoquée devant la survenue de méningite à répétition. Nous rapportons deux observations révélatrices, l'une d'un déficit en C2, l'autre en C5. La survenue d'une récidive de méningite doit faire rechercher une bréche méningée (surtout s'il s'agit d'une méningite à pneumocoque), une asplénie, un déficit en immunoglobuline et un déficit du système complémentaire. Dans ce cadre, il s'agit de la voie principale (C1, C2, C4) dans 12 %, de la voie alterne dans 42 %, de la voie terminale (C5 à C9) dans 46 %. Devant l'absence de traitement spécifique de ces déficits, une prophylaxie des infections est réalisée par la pénicilline V, et par les vaccinations (pneumo 23, méningocoque A C, Haemophilus influenzae).</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>B. Le Luyer</name><affiliations><json:string>Départment de Pédiatrie, CH Le Havre, 55 bis rue Gustave Flaubert - F-76600 Le Havre, France</json:string></affiliations></json:item><json:item><name>M. Blondet</name><affiliations><json:string>Départment de Pédiatrie, CH Le Havre, 55 bis rue Gustave Flaubert - F-76600 Le Havre, France</json:string></affiliations></json:item><json:item><name>P. Le Roux</name><affiliations><json:string>Départment de Pédiatrie, CH Le Havre, 55 bis rue Gustave Flaubert - F-76600 Le Havre, France</json:string></affiliations></json:item><json:item><name>J. Boulloche</name><affiliations><json:string>Départment de Pédiatrie, CH Le Havre, 55 bis rue Gustave Flaubert - F-76600 Le Havre, France</json:string></affiliations></json:item><json:item><name>M.T. Briquet</name><affiliations><json:string>Départment de Pédiatrie, CH Le Havre, 55 bis rue Gustave Flaubert - F-76600 Le Havre, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>fre</json:string></lang><value>Déficit en complément</value></json:item><json:item><lang><json:string>fre</json:string></lang><value>Méningite à répétition</value></json:item><json:item><lang><json:string>fre</json:string></lang><value>Neisseria meningitidis</value></json:item><json:item><lang><json:string>fre</json:string></lang><value>Collagénose</value></json:item><json:item><lang><json:string>fre</json:string></lang><value>Complement deficiency</value></json:item><json:item><lang><json:string>fre</json:string></lang><value>Recurrent meningitis</value></json:item><json:item><lang><json:string>fre</json:string></lang><value>Pneumococcus</value></json:item></subject><articleId><json:string>05816890</json:string></articleId><language><json:string>fre</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>A recurrent pneumococcus meningitis in a same child suggests among other etiologies such as meningeal leak and asplenie, the possibility of an immune deficiency as immunoglobulin or complement abnormality. Complement deficiency is observed in 12 % of the cases in the classical pathway (C1, C2, C4), 42 % in the alternative and 46 % in the terminal pathway. We report 2 cases of recurrent pneumococcal meningitis revealing a C1 and a C5 defect. 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Nous rapportons deux observations révélatrices, l'une d'un déficit en C2, l'autre en C5. La survenue d'une récidive de méningite doit faire rechercher une bréche méningée (surtout s'il s'agit d'une méningite à pneumocoque), une asplénie, un déficit en immunoglobuline et un déficit du système complémentaire. Dans ce cadre, il s'agit de la voie principale (C1, C2, C4) dans 12 %, de la voie alterne dans 42 %, de la voie terminale (C5 à C9) dans 46 %. Devant l'absence de traitement spécifique de ces déficits, une prophylaxie des infections est réalisée par la pénicilline V, et par les vaccinations (pneumo 23, méningocoque A C, Haemophilus influenzae).</p></abstract><abstract xml:lang="en"><p>Summary: A recurrent pneumococcus meningitis in a same child suggests among other etiologies such as meningeal leak and asplenie, the possibility of an immune deficiency as immunoglobulin or complement abnormality. Complement deficiency is observed in 12 % of the cases in the classical pathway (C1, C2, C4), 42 % in the alternative and 46 % in the terminal pathway. We report 2 cases of recurrent pneumococcal meningitis revealing a C1 and a C5 defect. Because of the absence of specific treatment of such deficiencies, prophylaxis using oral penicillin and vaccination is warranted.</p></abstract><textClass xml:lang="fr"><keywords scheme="keyword"><list><head>Mots-clés</head><item><term>Déficit en complément</term></item><item><term>Méningite à répétition</term></item><item><term>Neisseria meningitidis</term></item><item><term>Collagénose</term></item></list></keywords></textClass><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Key-words</head><item><term>Complement deficiency</term></item><item><term>Recurrent meningitis</term></item><item><term>Pneumococcus</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1995">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/D1F86DCE91240D3BB02FE9E88A482B196CA80068/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier doc found" wicri:toSee="Elsevier, no converted or simple article"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 5.0.1//EN//XML" URI="art501.dtd" name="istex:docType"></istex:docType><istex:document><article version="5.0" xml:lang="fr" docsubtype="fla"><item-info><jid>MEDMAL</jid><aid>05816890</aid><ce:pii>S0399-077X(05)81689-0</ce:pii><ce:doi>10.1016/S0399-077X(05)81689-0</ce:doi><ce:copyright type="unknown" year="1995"></ce:copyright></item-info><head><ce:article-footnote><ce:label>*</ce:label><ce:note-para>12<ce:sup loc="post">e</ce:sup> Journée de Pathologie Infectieuse Pédiatrique, Paris, 16–17 mai 1995.</ce:note-para></ce:article-footnote><ce:title>Méningites à répétition et déficit en facteurs du complément</ce:title><ce:alt-title xml:lang="en">Recurrent meningitis and complement deficiency</ce:alt-title><ce:author-group><ce:author><ce:given-name>B.</ce:given-name><ce:surname>Le Luyer</ce:surname><ce:cross-ref refid="aff1"><ce:sup>**</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>M.</ce:given-name><ce:surname>Blondet</ce:surname><ce:cross-ref refid="aff1"><ce:sup>**</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>P.</ce:given-name><ce:surname>Le Roux</ce:surname><ce:cross-ref refid="aff1"><ce:sup>**</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>J.</ce:given-name><ce:surname>Boulloche</ce:surname><ce:cross-ref refid="aff1"><ce:sup>**</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>M.T.</ce:given-name><ce:surname>Briquet</ce:surname><ce:cross-ref refid="aff1"><ce:sup>**</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="aff1"><ce:label>**</ce:label><ce:textfn>Départment de Pédiatrie, CH Le Havre, 55 bis rue Gustave Flaubert - F-76600 Le Havre, France</ce:textfn></ce:affiliation></ce:author-group><ce:abstract id="ab1" class="author" xml:lang="fr"><ce:section-title>Resume</ce:section-title><ce:abstract-sec><ce:simple-para>La possibilité d'un déficit en composant du complément doit être évoquée devant la survenue de méningite à répétition. Nous rapportons deux observations révélatrices, l'une d'un déficit en C<ce:inf loc="post">2</ce:inf>, l'autre en C<ce:inf loc="post">5</ce:inf>. La survenue d'une récidive de méningite doit faire rechercher une bréche méningée (surtout s'il s'agit d'une méningite à pneumocoque), une asplénie, un déficit en immunoglobuline et un déficit du système complémentaire. Dans ce cadre, il s'agit de la voie principale (C<ce:inf loc="post">1</ce:inf>, C<ce:inf loc="post">2</ce:inf>, C<ce:inf loc="post">4</ce:inf>) dans 12 %, de la voie alterne dans 42 %, de la voie terminale (C<ce:inf loc="post">5</ce:inf> à C<ce:inf loc="post">9</ce:inf>) dans 46 %. Devant l'absence de traitement spécifique de ces déficits, une prophylaxie des infections est réalisée par la pénicilline V, et par les vaccinations (pneumo 23, méningocoque A C, <ce:italic>Haemophilus influenzae</ce:italic>).</ce:simple-para></ce:abstract-sec></ce:abstract><ce:abstract id="ab2" class="author" xml:lang="en"><ce:section-title>Summary</ce:section-title><ce:abstract-sec><ce:simple-para>A recurrent pneumococcus meningitis in a same child suggests among other etiologies such as meningeal leak and asplenie, the possibility of an immune deficiency as immunoglobulin or complement abnormality. Complement deficiency is observed in 12 % of the cases in the classical pathway (C<ce:inf loc="post">1</ce:inf>, C<ce:inf loc="post">2</ce:inf>, C<ce:inf loc="post">4</ce:inf>), 42 % in the alternative and 46 % in the terminal pathway. We report 2 cases of recurrent pneumococcal meningitis revealing a C<ce:inf loc="post">1</ce:inf> and a C<ce:inf loc="post">5</ce:inf> defect. Because of the absence of specific treatment of such deficiencies, prophylaxis using oral penicillin and vaccination is warranted.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword" xml:lang="fr"><ce:section-title>Mots-clés</ce:section-title><ce:keyword><ce:text>Déficit en complément</ce:text></ce:keyword><ce:keyword><ce:text>Méningite à répétition</ce:text></ce:keyword><ce:keyword><ce:text><ce:italic>Neisseria meningitidis</ce:italic></ce:text></ce:keyword><ce:keyword><ce:text>Collagénose</ce:text></ce:keyword></ce:keywords><ce:keywords class="keyword" xml:lang="en"><ce:section-title>Key-words</ce:section-title><ce:keyword><ce:text>Complement deficiency</ce:text></ce:keyword><ce:keyword><ce:text>Recurrent meningitis</ce:text></ce:keyword><ce:keyword><ce:text>Pneumococcus</ce:text></ce:keyword></ce:keywords></head><tail><ce:bibliography><ce:section-title>References</ce:section-title><ce:bibliography-sec><ce:bib-reference id="bib1"><ce:label>1.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Griscelli</ce:surname><ce:given-name>C.</ce:given-name></sb:author><sb:author><ce:surname>Paupe</ce:surname><ce:given-name>J.</ce:given-name></sb:author><sb:author><ce:surname>Ponvert</ce:surname><ce:given-name>C.</ce:given-name></sb:author></sb:authors></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Immunopathologie. 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déficit en facteurs du complément</title></titleInfo><titleInfo type="alternative" lang="fr" contentType="CDATA"><title>Méningites à répétition et déficit en facteurs du complément</title></titleInfo><titleInfo type="translated" lang="en"><title>Recurrent meningitis and complement deficiency</title></titleInfo><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Le Luyer</namePart><affiliation>Départment de Pédiatrie, CH Le Havre, 55 bis rue Gustave Flaubert - F-76600 Le Havre, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Blondet</namePart><affiliation>Départment de Pédiatrie, CH Le Havre, 55 bis rue Gustave Flaubert - F-76600 Le Havre, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Le Roux</namePart><affiliation>Départment de Pédiatrie, CH Le Havre, 55 bis rue Gustave Flaubert - F-76600 Le Havre, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Boulloche</namePart><affiliation>Départment de Pédiatrie, CH Le Havre, 55 bis rue Gustave Flaubert - F-76600 Le Havre, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.T.</namePart><namePart type="family">Briquet</namePart><affiliation>Départment de Pédiatrie, CH Le Havre, 55 bis rue Gustave Flaubert - F-76600 Le Havre, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1995</dateIssued><copyrightDate encoding="w3cdtf">1995</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">fre</languageTerm><languageTerm type="code" authority="rfc3066">fr</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="fr">Resume: La possibilité d'un déficit en composant du complément doit être évoquée devant la survenue de méningite à répétition. Nous rapportons deux observations révélatrices, l'une d'un déficit en C2, l'autre en C5. La survenue d'une récidive de méningite doit faire rechercher une bréche méningée (surtout s'il s'agit d'une méningite à pneumocoque), une asplénie, un déficit en immunoglobuline et un déficit du système complémentaire. Dans ce cadre, il s'agit de la voie principale (C1, C2, C4) dans 12 %, de la voie alterne dans 42 %, de la voie terminale (C5 à C9) dans 46 %. Devant l'absence de traitement spécifique de ces déficits, une prophylaxie des infections est réalisée par la pénicilline V, et par les vaccinations (pneumo 23, méningocoque A C, Haemophilus influenzae).</abstract><abstract lang="en">Summary: A recurrent pneumococcus meningitis in a same child suggests among other etiologies such as meningeal leak and asplenie, the possibility of an immune deficiency as immunoglobulin or complement abnormality. Complement deficiency is observed in 12 % of the cases in the classical pathway (C1, C2, C4), 42 % in the alternative and 46 % in the terminal pathway. We report 2 cases of recurrent pneumococcal meningitis revealing a C1 and a C5 defect. Because of the absence of specific treatment of such deficiencies, prophylaxis using oral penicillin and vaccination is warranted.</abstract><note>12e Journée de Pathologie Infectieuse Pédiatrique, Paris, 16–17 mai 1995.</note><subject lang="fr"><genre>Mots-clés</genre><topic>Déficit en complément</topic><topic>Méningite à répétition</topic><topic>Neisseria meningitidis</topic><topic>Collagénose</topic></subject><subject lang="en"><genre>Key-words</genre><topic>Complement deficiency</topic><topic>Recurrent meningitis</topic><topic>Pneumococcus</topic></subject><relatedItem type="host"><titleInfo><title>Medecine et Maladies Infectieuses</title></titleInfo><titleInfo type="abbreviated"><title>MEDMAL</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199501</dateIssued></originInfo><identifier type="ISSN">0399-077X</identifier><identifier type="PII">S0399-077X(05)X8714-5</identifier><part><date>199501</date><detail type="volume"><number>25</number><caption>vol.</caption></detail><detail type="supplement"><number>S3</number><caption>Suppl.</caption></detail><extent unit="issue pages"><start>1230</start><end>1347</end></extent><extent unit="pages"><start>1313</start><end>1317</end></extent></part></relatedItem><identifier type="istex">D1F86DCE91240D3BB02FE9E88A482B196CA80068</identifier><identifier type="DOI">10.1016/S0399-077X(05)81689-0</identifier><identifier type="PII">S0399-077X(05)81689-0</identifier><identifier type="ArticleID">05816890</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/D1F86DCE91240D3BB02FE9E88A482B196CA80068/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">INFECTIOUS DISEASES</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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