Treatment of primary Sjögren syndrome with rituximab: a randomized trial.
Identifieur interne : 000358 ( Hal/Curation ); précédent : 000357; suivant : 000359Treatment of primary Sjögren syndrome with rituximab: a randomized trial.
Auteurs : Valérie Devauchelle-Pensec [France] ; Xavier Mariette [France] ; Sandrine Jousse-Joulin [France] ; Jean-Marie Berthelot [France] ; Aleth Perdriger [France] ; Xavier Puéchal [France] ; Véronique Le Guern [France] ; Jean Sibilia [France] ; Jacques-Eric Gottenberg [France] ; Laurent Chiche [France] ; Eric Hachulla [France] ; Pierre Yves Hatron ; Vincent Goeb [France] ; Gilles Hayem [France] ; Jacques Morel [France] ; Charles Zarnitsky [France] ; Jean Jacques Dubost ; Jacques-Olivier Pers [France] ; Emmanuel Nowak [France] ; Alain Saraux [France]Source :
- Annals of Internal Medicine [ 0003-4819 ] ; 2014-02-18.
Abstract
BACKGROUND: Primary Sjögren syndrome (pSS) is an autoimmune disorder characterized by ocular and oral dryness or systemic manifestations. OBJECTIVE: To evaluate efficacy and harms of rituximab in adults with recent-onset or systemic pSS. DESIGN: Randomized, placebo-controlled, parallel-group trial conducted between March 2008 and January 2011. Study personnel (except pharmacists), investigators, and patients were blinded to treatment group. (ClinicalTrials.gov: NCT00740948). SETTING: 14 university hospitals in France. PATIENTS: 120 patients with scores of 50 mm or greater on at least 2 of 4 visual analogue scales (VASs) (global disease, pain, fatigue, and dryness) and recent-onset (< 10 years) biologically active or systemic pSS. INTERVENTION: Randomization (1:1 ratio) to rituximab (1 g at weeks 0 and 2) or placebo. MEASUREMENTS: Primary end point was improvement of at least 30 mm in 2 of 4 VASs by week 24. RESULTS: No significant difference between groups in the primary end point was found (difference, 1.0% [95% CI, -16.7% to 18.7%]). The proportion of patients with at least 30-mm decreases in at least two of the four VAS scores was higher in the rituximab group at week 6 (22.4% vs. 9.1%; P = 0.036). An improvement of at least 30 mm in VAS fatigue score was more common with rituximab at weeks 6 (P < 0.001) and 16 (P = 0.012), and improvement in fatigue from baseline to week 24 was greater with rituximab. Adverse events were similar between groups except for a higher rate of infusion reactions with rituximab. LIMITATION: Low disease activity at baseline and a primary outcome that may have been insensitive to detect clinically important changes. CONCLUSION: Rituximab did not alleviate symptoms or disease activity in patients with pSS at week 24, although it alleviated some symptoms at earlier time points.
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DOI: 10.7326/M13-1085
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key="FR"></country></address></desc></org></tutelle><tutelle active="#struct-334740" type="direct"><org type="institution" xml:id="struct-334740" status="INCOMING"><orgName>AP-HP</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Morel, Jacques" sort="Morel, Jacques" uniqKey="Morel J" first="Jacques" last="Morel">Jacques Morel</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-14059" status="VALID"><orgName>Hôpital Lapeyronie</orgName><desc><address><addrLine>371, avenue du Doyen Gaston Giraud 34295 MONTPELLIER cedex 5</addrLine><country key="FR"></country></address></desc><listRelation><relation active="#struct-258773" type="direct"></relation><relation active="#struct-300154" type="direct"></relation><relation active="#struct-42570" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-258773" 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type="url">http://www.univ-montp1.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Montpellier</settlement><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Languedoc-Roussillon</region></placeName><orgName type="university">Université Montpellier 1</orgName><orgName type="institution" wicri:auto="newGroup">PRES Sud de France</orgName></affiliation></author><author><name sortKey="Zarnitsky, Charles" sort="Zarnitsky, Charles" uniqKey="Zarnitsky C" first="Charles" last="Zarnitsky">Charles Zarnitsky</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-213170" status="INCOMING"> <orgName>Service de Rhumatologie - CH Le Havre</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-352019" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-352019" type="direct"><org type="institution" xml:id="struct-352019" status="INCOMING"> <orgName>CH Le Havre</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Dubost, Jean Jacques" sort="Dubost, Jean Jacques" uniqKey="Dubost J" first="Jean Jacques" last="Dubost">Jean Jacques Dubost</name></author><author><name sortKey="Pers, Jacques Olivier" sort="Pers, Jacques Olivier" uniqKey="Pers J" first="Jacques-Olivier" last="Pers">Jacques-Olivier Pers</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-156771" status="VALID"><orgName>Immunologie et Pathologie</orgName><orgName type="acronym">EA2216</orgName><desc><address><addrLine>CHU Morvan, 5 Rue Foch, BP 824, 29609 Brest</addrLine><country key="FR"></country></address></desc><listRelation><relation name="EA2216" active="#struct-300314" type="direct"></relation><relation 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Bretagne</orgName></affiliation></author><author><name sortKey="Nowak, Emmanuel" sort="Nowak, Emmanuel" uniqKey="Nowak E" first="Emmanuel" last="Nowak">Emmanuel Nowak</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-144531" status="VALID"><orgName>Centre d'Investigation Clinique</orgName><orgName type="acronym">CIC - Brest</orgName><desc><address><addrLine>CHU de la Cavale Blanche 29609 Brest</addrLine><country key="FR"></country></address></desc><listRelation><relation active="#struct-300314" type="direct"></relation><relation name="CIC502" active="#struct-303623" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-300314" type="direct"><org type="institution" xml:id="struct-300314" status="VALID"><orgName>Université de Bretagne Occidentale</orgName><orgName type="acronym">UBO</orgName><desc><address><addrLine>3 Rue des Archives 29238 Brest</addrLine><country key="FR"></country></address></desc></org></tutelle><tutelle name="CIC502" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Brest</settlement><region type="region" nuts="2">Région Bretagne</region></placeName><orgName type="university">Université de Bretagne Occidentale</orgName><orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName></affiliation></author><author><name sortKey="Saraux, Alain" sort="Saraux, Alain" uniqKey="Saraux A" first="Alain" last="Saraux">Alain Saraux</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-156771" status="VALID"><orgName>Immunologie et Pathologie</orgName><orgName type="acronym">EA2216</orgName><desc><address><addrLine>CHU Morvan, 5 Rue Foch, BP 824, 29609 Brest</addrLine><country key="FR"></country></address></desc><listRelation><relation name="EA2216" active="#struct-300314" type="direct"></relation><relation active="#struct-339539" type="direct"></relation></listRelation><tutelles><tutelle name="EA2216" active="#struct-300314" type="direct"><org type="institution" xml:id="struct-300314" status="VALID"><orgName>Université de Bretagne Occidentale</orgName><orgName type="acronym">UBO</orgName><desc><address><addrLine>3 Rue des Archives 29238 Brest</addrLine><country key="FR"></country></address></desc></org></tutelle><tutelle active="#struct-339539" type="direct"><org type="institution" xml:id="struct-339539" status="INCOMING"><orgName>IFR148</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Brest</settlement><region type="region" nuts="2">Région Bretagne</region></placeName><orgName type="university">Université de Bretagne Occidentale</orgName><orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName></affiliation></author></analytic><idno type="DOI">10.7326/M13-1085</idno><series><title level="j">Annals of Internal Medicine</title><idno type="ISSN">0003-4819</idno><imprint><date type="datePub">2014-02-18</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">BACKGROUND: Primary Sjögren syndrome (pSS) is an autoimmune disorder characterized by ocular and oral dryness or systemic manifestations. OBJECTIVE: To evaluate efficacy and harms of rituximab in adults with recent-onset or systemic pSS. DESIGN: Randomized, placebo-controlled, parallel-group trial conducted between March 2008 and January 2011. Study personnel (except pharmacists), investigators, and patients were blinded to treatment group. (ClinicalTrials.gov: NCT00740948). SETTING: 14 university hospitals in France. PATIENTS: 120 patients with scores of 50 mm or greater on at least 2 of 4 visual analogue scales (VASs) (global disease, pain, fatigue, and dryness) and recent-onset (< 10 years) biologically active or systemic pSS. INTERVENTION: Randomization (1:1 ratio) to rituximab (1 g at weeks 0 and 2) or placebo. MEASUREMENTS: Primary end point was improvement of at least 30 mm in 2 of 4 VASs by week 24. RESULTS: No significant difference between groups in the primary end point was found (difference, 1.0% [95% CI, -16.7% to 18.7%]). The proportion of patients with at least 30-mm decreases in at least two of the four VAS scores was higher in the rituximab group at week 6 (22.4% vs. 9.1%; P = 0.036). An improvement of at least 30 mm in VAS fatigue score was more common with rituximab at weeks 6 (P < 0.001) and 16 (P = 0.012), and improvement in fatigue from baseline to week 24 was greater with rituximab. Adverse events were similar between groups except for a higher rate of infusion reactions with rituximab. LIMITATION: Low disease activity at baseline and a primary outcome that may have been insensitive to detect clinically important changes. CONCLUSION: Rituximab did not alleviate symptoms or disease activity in patients with pSS at week 24, although it alleviated some symptoms at earlier time points.</div></front></TEI><hal api="V3"><titleStmt><title xml:lang="en">Treatment of primary Sjögren syndrome with rituximab: a randomized trial.</title><author role="aut"><persName><forename type="first">Valérie</forename><surname>Devauchelle-Pensec</surname></persName><email></email><idno type="halauthor">760809</idno><affiliation ref="#struct-303644"></affiliation><affiliation ref="#struct-156771"></affiliation><affiliation ref="#struct-202668"></affiliation></author><author role="aut"><persName><forename type="first">Xavier</forename><surname>Mariette</surname></persName><email></email><idno type="halauthor">117620</idno><affiliation ref="#struct-106183"></affiliation></author><author role="aut"><persName><forename type="first">Sandrine</forename><surname>Jousse-Joulin</surname></persName><email></email><idno type="halauthor">760750</idno><affiliation ref="#struct-156771"></affiliation><affiliation ref="#struct-202668"></affiliation><affiliation ref="#struct-303644"></affiliation></author><author role="aut"><persName><forename type="first">Jean-Marie</forename><surname>Berthelot</surname></persName><email></email><idno type="halauthor">406504</idno><affiliation ref="#struct-81510"></affiliation></author><author role="aut"><persName><forename type="first">Aleth</forename><surname>Perdriger</surname></persName><email></email><idno type="halauthor">253659</idno><affiliation ref="#struct-53270"></affiliation></author><author role="aut"><persName><forename type="first">Xavier</forename><surname>Puéchal</surname></persName><email></email><idno type="halauthor">304109</idno><affiliation ref="#struct-189806"></affiliation><affiliation ref="#struct-106187"></affiliation></author><author role="aut"><persName><forename type="first">Véronique</forename><surname>Le Guern</surname></persName><email></email><idno type="halauthor">972732</idno><affiliation ref="#struct-192639"></affiliation><affiliation ref="#struct-192648"></affiliation></author><author role="aut"><persName><forename type="first">Jean</forename><surname>Sibilia</surname></persName><email></email><idno type="halauthor">117618</idno><affiliation ref="#struct-245292"></affiliation></author><author role="aut"><persName><forename type="first">Jacques-Eric</forename><surname>Gottenberg</surname></persName><email></email><idno type="halauthor">117611</idno><affiliation ref="#struct-222993"></affiliation></author><author role="aut"><persName><forename type="first">Laurent</forename><surname>Chiche</surname></persName><email></email><idno type="halauthor">408368</idno><affiliation ref="#struct-182245"></affiliation><affiliation ref="#struct-50970"></affiliation></author><author role="aut"><persName><forename type="first">Eric</forename><surname>Hachulla</surname></persName><email></email><idno type="halauthor">238132</idno><affiliation ref="#struct-160769"></affiliation></author><author role="aut"><persName><forename type="first">Pierre Yves</forename><surname>Hatron</surname></persName><email></email><idno type="halauthor">365678</idno></author><author role="aut"><persName><forename type="first">Vincent</forename><surname>Goeb</surname></persName><email></email><idno type="halauthor">638185</idno><affiliation ref="#struct-18378"></affiliation></author><author role="aut"><persName><forename type="first">Gilles</forename><surname>Hayem</surname></persName><email></email><idno type="halauthor">1019585</idno><affiliation ref="#struct-193704"></affiliation></author><author role="aut"><persName><forename type="first">Jacques</forename><surname>Morel</surname></persName><email></email><idno type="halauthor">474053</idno><affiliation ref="#struct-14059"></affiliation></author><author role="aut"><persName><forename type="first">Charles</forename><surname>Zarnitsky</surname></persName><email></email><idno type="halauthor">637450</idno><affiliation ref="#struct-213170"></affiliation></author><author role="aut"><persName><forename type="first">Jean Jacques</forename><surname>Dubost</surname></persName><email></email><idno type="halauthor">1019586</idno></author><author role="aut"><persName><forename type="first">Jacques-Olivier</forename><surname>Pers</surname></persName><email></email><idno type="halauthor">337512</idno><affiliation ref="#struct-156771"></affiliation></author><author role="aut"><persName><forename type="first">Emmanuel</forename><surname>Nowak</surname></persName><email></email><idno type="halauthor">702313</idno><affiliation ref="#struct-144531"></affiliation></author><author role="aut"><persName><forename type="first">Alain</forename><surname>Saraux</surname></persName><email></email><idno type="halauthor">474143</idno><affiliation ref="#struct-156771"></affiliation><affiliation ref="#struct-202668"></affiliation><affiliation ref="#struct-303644"></affiliation></author><editor role="depositor"><persName><forename>Geneviève</forename><surname>Michel</surname></persName><email>secretariat-immunologie@chu-brest.fr</email></editor></titleStmt><editionStmt><edition n="v1" type="current"><date type="whenSubmitted">2014-05-06 15:46:53</date><date type="whenModified">2016-10-11 13:41:56</date><date type="whenReleased">2014-05-06 15:46:53</date><date type="whenProduced">2014-02-18</date></edition><respStmt><resp>contributor</resp><name key="176925"><persName><forename>Geneviève</forename><surname>Michel</surname></persName><email>secretariat-immunologie@chu-brest.fr</email></name></respStmt></editionStmt><publicationStmt><distributor>CCSD</distributor><idno type="halId">hal-00987652</idno><idno type="halUri">http://hal.univ-brest.fr/hal-00987652</idno><idno type="halBibtex">devauchellepensec:hal-00987652</idno><idno type="halRefHtml">Annals of Internal Medicine, American College of Physicians, 2014, 160 (4), pp.233-42. <10.7326/M13-1085></idno><idno type="halRef">Annals of Internal Medicine, American College of Physicians, 2014, 160 (4), pp.233-42. <10.7326/M13-1085></idno></publicationStmt><seriesStmt><idno type="stamp" n="UNIV-PARIS5">Université Paris Descartes (Paris 5)</idno><idno type="stamp" n="UNIV-BREST">Université de Bretagne occidentale - Brest</idno><idno type="stamp" n="UNIV-PARIS7">Université Denis Diderot - Paris VII</idno><idno type="stamp" n="UNIV-NANTES">Université de Nantes</idno><idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno><idno type="stamp" n="APHP" p="INSERM">AP-HP</idno><idno type="stamp" n="UNIV-STRASBG">Université de Strasbourg</idno><idno type="stamp" n="UNIV-AMU">Aix Marseille Université</idno><idno type="stamp" n="IMMUNO" p="UNIV-BREST">Immunothérapies et Pathologies lymphocytaires B - EA 2216 </idno><idno type="stamp" n="USPC">Université Sorbonne Paris Cité</idno></seriesStmt><notesStmt><note type="audience" n="2">International</note><note type="popular" n="0">No</note><note type="peer" n="1">Yes</note></notesStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Treatment of primary Sjögren syndrome with rituximab: a randomized trial.</title><author role="aut"><persName><forename type="first">Valérie</forename><surname>Devauchelle-Pensec</surname></persName><idno type="halAuthorId">760809</idno><affiliation ref="#struct-303644"></affiliation><affiliation ref="#struct-156771"></affiliation><affiliation ref="#struct-202668"></affiliation></author><author role="aut"><persName><forename type="first">Xavier</forename><surname>Mariette</surname></persName><idno type="halAuthorId">117620</idno><affiliation ref="#struct-106183"></affiliation></author><author role="aut"><persName><forename type="first">Sandrine</forename><surname>Jousse-Joulin</surname></persName><idno type="halAuthorId">760750</idno><affiliation ref="#struct-156771"></affiliation><affiliation ref="#struct-202668"></affiliation><affiliation ref="#struct-303644"></affiliation></author><author role="aut"><persName><forename type="first">Jean-Marie</forename><surname>Berthelot</surname></persName><idno type="halAuthorId">406504</idno><affiliation ref="#struct-81510"></affiliation></author><author role="aut"><persName><forename type="first">Aleth</forename><surname>Perdriger</surname></persName><idno type="halAuthorId">253659</idno><affiliation ref="#struct-53270"></affiliation></author><author role="aut"><persName><forename type="first">Xavier</forename><surname>Puéchal</surname></persName><idno type="halAuthorId">304109</idno><affiliation ref="#struct-189806"></affiliation><affiliation ref="#struct-106187"></affiliation></author><author role="aut"><persName><forename type="first">Véronique</forename><surname>Le Guern</surname></persName><idno type="halAuthorId">972732</idno><affiliation ref="#struct-192639"></affiliation><affiliation ref="#struct-192648"></affiliation></author><author role="aut"><persName><forename type="first">Jean</forename><surname>Sibilia</surname></persName><idno type="halAuthorId">117618</idno><affiliation ref="#struct-245292"></affiliation></author><author role="aut"><persName><forename type="first">Jacques-Eric</forename><surname>Gottenberg</surname></persName><idno type="halAuthorId">117611</idno><affiliation ref="#struct-222993"></affiliation></author><author role="aut"><persName><forename type="first">Laurent</forename><surname>Chiche</surname></persName><idno type="halAuthorId">408368</idno><affiliation ref="#struct-182245"></affiliation><affiliation ref="#struct-50970"></affiliation></author><author role="aut"><persName><forename type="first">Eric</forename><surname>Hachulla</surname></persName><idno type="halAuthorId">238132</idno><affiliation ref="#struct-160769"></affiliation></author><author role="aut"><persName><forename type="first">Pierre Yves</forename><surname>Hatron</surname></persName><idno type="halAuthorId">365678</idno></author><author role="aut"><persName><forename type="first">Vincent</forename><surname>Goeb</surname></persName><idno type="halAuthorId">638185</idno><affiliation ref="#struct-18378"></affiliation></author><author role="aut"><persName><forename type="first">Gilles</forename><surname>Hayem</surname></persName><idno type="halAuthorId">1019585</idno><affiliation ref="#struct-193704"></affiliation></author><author role="aut"><persName><forename type="first">Jacques</forename><surname>Morel</surname></persName><idno type="halAuthorId">474053</idno><affiliation ref="#struct-14059"></affiliation></author><author role="aut"><persName><forename type="first">Charles</forename><surname>Zarnitsky</surname></persName><idno type="halAuthorId">637450</idno><affiliation ref="#struct-213170"></affiliation></author><author role="aut"><persName><forename type="first">Jean Jacques</forename><surname>Dubost</surname></persName><idno type="halAuthorId">1019586</idno></author><author role="aut"><persName><forename type="first">Jacques-Olivier</forename><surname>Pers</surname></persName><idno type="halAuthorId">337512</idno><affiliation ref="#struct-156771"></affiliation></author><author role="aut"><persName><forename type="first">Emmanuel</forename><surname>Nowak</surname></persName><idno type="halAuthorId">702313</idno><affiliation ref="#struct-144531"></affiliation></author><author role="aut"><persName><forename type="first">Alain</forename><surname>Saraux</surname></persName><idno type="halAuthorId">474143</idno><affiliation ref="#struct-156771"></affiliation><affiliation ref="#struct-202668"></affiliation><affiliation ref="#struct-303644"></affiliation></author></analytic><monogr><idno type="halJournalId" status="VALID">22712</idno><idno type="issn">0003-4819</idno><idno type="eissn">1539-3704</idno><title level="j">Annals of Internal Medicine</title><imprint><publisher>American College of Physicians</publisher><biblScope unit="volume">160</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="pp">233-42</biblScope><date type="datePub">2014-02-18</date></imprint></monogr><idno type="doi">10.7326/M13-1085</idno><idno type="pubmed">24727841</idno></biblStruct></sourceDesc><profileDesc><langUsage><language ident="en">English</language></langUsage><textClass><classCode scheme="halDomain" n="sdv.imm">Life Sciences [q-bio]/Immunology</classCode><classCode scheme="halTypology" n="ART">Journal articles</classCode></textClass><abstract xml:lang="en">BACKGROUND: Primary Sjögren syndrome (pSS) is an autoimmune disorder characterized by ocular and oral dryness or systemic manifestations. OBJECTIVE: To evaluate efficacy and harms of rituximab in adults with recent-onset or systemic pSS. DESIGN: Randomized, placebo-controlled, parallel-group trial conducted between March 2008 and January 2011. Study personnel (except pharmacists), investigators, and patients were blinded to treatment group. (ClinicalTrials.gov: NCT00740948). SETTING: 14 university hospitals in France. PATIENTS: 120 patients with scores of 50 mm or greater on at least 2 of 4 visual analogue scales (VASs) (global disease, pain, fatigue, and dryness) and recent-onset (< 10 years) biologically active or systemic pSS. INTERVENTION: Randomization (1:1 ratio) to rituximab (1 g at weeks 0 and 2) or placebo. MEASUREMENTS: Primary end point was improvement of at least 30 mm in 2 of 4 VASs by week 24. RESULTS: No significant difference between groups in the primary end point was found (difference, 1.0% [95% CI, -16.7% to 18.7%]). The proportion of patients with at least 30-mm decreases in at least two of the four VAS scores was higher in the rituximab group at week 6 (22.4% vs. 9.1%; P = 0.036). An improvement of at least 30 mm in VAS fatigue score was more common with rituximab at weeks 6 (P < 0.001) and 16 (P = 0.012), and improvement in fatigue from baseline to week 24 was greater with rituximab. Adverse events were similar between groups except for a higher rate of infusion reactions with rituximab. LIMITATION: Low disease activity at baseline and a primary outcome that may have been insensitive to detect clinically important changes. CONCLUSION: Rituximab did not alleviate symptoms or disease activity in patients with pSS at week 24, although it alleviated some symptoms at earlier time points.</abstract></profileDesc></hal></record>Pour manipuler ce document sous Unix (Dilib)
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|étape= Curation
|type= RBID
|clé= Hal:hal-00987652
|texte= Treatment of primary Sjögren syndrome with rituximab: a randomized trial.
}}
| This area was generated with Dilib version V0.6.25. |  |