Somatostatin receptor scintigraphy screening in advanced hepatocarcinoma: A multi-center French study.
Identifieur interne : 000300 ( Hal/Curation ); précédent : 000299; suivant : 000301Somatostatin receptor scintigraphy screening in advanced hepatocarcinoma: A multi-center French study.
Auteurs : Eric Nguyen-Khac [France] ; Isabelle Ollivier [France] ; Thomas Aparicio [France] ; Véronique Moullart [France] ; Alexis Hugentobler [France] ; Rachida Lebtahi [France] ; Céline Lobry [France] ; Christiane Susini [France] ; Christian Duhamel [France] ; Séverine Hommel [France] ; Jean François Cadranel [France] ; Jean-Paul Joly [France] ; Jean Claude Barbare [France] ; Blaise Tramier [France] ; Jean Louis Dupas [France]Source :
- Cancer Biology and Therapy [ 1538-4047 ] ; 2009-11.
Abstract
BACKGROUND: Somatostatin receptor scintigraphy (SRS) has been reported for receptor (SSTR) screening in advanced hepatocarcinoma (aHC) prior to somatostatin analogue treatment. AIMS: To evaluate SSTR screening with SRS in aHC patients. RESULTS: Seventy aHC patients (63 men) aged 65 +/- 11 y were included, with alcohol, viral or other causes cirrhosis in 35 (50%), 23 (33%), 12 (17%) cases respectively. CLIP score was 2.7 +/- 1.7, with more than three nodules in 37 (53%) cases. Largest nodule measured 7.6 +/- 4.5 cm. Median alpha-fetoprotein was 574 UI/mL. SRS was positive in 25/70 (35.7%) livers and 7/17 (41.2%) metastatic sites. Positive SRS patients differed from others for tumor size (9.2 +/- 4 vs. 6.7 +/- 4.6 cm, p = 0.03), prothrombin time (PT) (75.2 +/- 15.2 vs. 61.9 +/- 19%, p = 0.005), albumin (34.1 +/- 5.9 vs. 30.5 +/- 7.2 g/L, p = 0.04) and Child-Pugh (6.7 +/- 1.8 vs. 7.7 +/- 2.3, p = 0.04). After multivariate analysis, only PT was associated with positive SRS (p = 0.028). Immunohistochemistry was positive for SSTR2s in 6/7 tumors (SRS uptake in 5/6 cases). METHODS: SRS was performed prior treatment, with images at 4, 24 and 48 h. For seven tumors, SSTR2 subtype was detected immunohistochemically. CONCLUSIONS: In advanced hepatocarcinoma, we report SRS uptake in 35.7% of livers and 41.2% of metastatic sites. SRS value in screening patients for somatostatin analogue treatment remains to be assessed.
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French study.</title><author><name sortKey="Nguyen Khac, Eric" sort="Nguyen Khac, Eric" uniqKey="Nguyen Khac E" first="Eric" last="Nguyen-Khac">Eric Nguyen-Khac</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-101666" status="INCOMING"><orgName>Service d'Hépato-Gastroentérologie</orgName><desc><address><addrLine>place Victor Pauchet, Amiens, F-80054 cedex 01</addrLine><country key="FR"></country></address></desc><listRelation><relation active="#struct-300535" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-300535" type="direct"><org type="institution" xml:id="struct-300535" status="VALID"><orgName>CHU AMIENS</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Ollivier, Isabelle" sort="Ollivier, Isabelle" uniqKey="Ollivier I" first="Isabelle" last="Ollivier">Isabelle Ollivier</name><affiliation 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key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Susini, Christiane" sort="Susini, Christiane" uniqKey="Susini C" first="Christiane" last="Susini">Christiane Susini</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2893" status="OLD"><orgName>Biologie et Pathologie Digestive</orgName><desc><address><addrLine>Hopital de Rangueil 31432 TOULOUSE CEDEX 4</addrLine><country key="FR"></country></address><ref type="url">http://www-toulouse.inserm.fr/u531.asp</ref></desc><listRelation><relation active="#struct-217752" type="direct"></relation><relation active="#struct-300625" type="direct"></relation><relation name="U531" active="#struct-303623" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-217752" type="direct"><org type="institution" xml:id="struct-217752" status="VALID"> <orgName>Université Paul Sabatier - Toulouse 3</orgName> <orgName type="acronym">UPS</orgName> <desc> <address> <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-tlse3.fr/</ref> </desc></org></tutelle><tutelle active="#struct-300625" type="direct"><org type="institution" xml:id="struct-300625" status="VALID"><orgName>IFR31</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle><tutelle name="U531" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Duhamel, Christian" sort="Duhamel, Christian" uniqKey="Duhamel C" first="Christian" last="Duhamel">Christian Duhamel</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-101674" status="INCOMING"><orgName>Service d'Hépato-Gastroentérologie</orgName><desc><address><addrLine>BP 24, Le Havre, F-76083 cedex</addrLine><country key="FR"></country></address></desc><listRelation><relation active="#struct-324517" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-324517" type="direct"><org type="institution" xml:id="struct-324517" status="INCOMING"><orgName>Groupe Hospitalier Le Havre</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Hommel, Severine" sort="Hommel, Severine" uniqKey="Hommel S" first="Séverine" last="Hommel">Séverine Hommel</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-95536" status="VALID"><orgName>Service d'Hépato-Gastroentérologie</orgName><desc><address><country key="FR"></country></address></desc><listRelation><relation active="#struct-300106" type="direct"></relation><relation active="#struct-300147" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-300106" type="direct"><org type="institution" xml:id="struct-300106" status="VALID"><orgName>Hôpital Charles Nicolle</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle><tutelle active="#struct-300147" type="direct"><org type="institution" xml:id="struct-300147" status="VALID"><orgName>CHU Rouen</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Cadranel, Jean Francois" sort="Cadranel, Jean Francois" uniqKey="Cadranel J" first="Jean François" last="Cadranel">Jean François Cadranel</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-101676" status="INCOMING"><orgName>Service d'Hépato-Gastroentérologie</orgName><desc><address><addrLine>boulevard Laennec, Creil F-60100</addrLine><country key="FR"></country></address></desc><listRelation><relation active="#struct-324518" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-324518" type="direct"><org type="institution" xml:id="struct-324518" status="INCOMING"><orgName>CH Laennec de Creil</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Joly, Jean Paul" sort="Joly, Jean Paul" uniqKey="Joly J" first="Jean-Paul" last="Joly">Jean-Paul Joly</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-101666" status="INCOMING"><orgName>Service d'Hépato-Gastroentérologie</orgName><desc><address><addrLine>place Victor Pauchet, Amiens, F-80054 cedex 01</addrLine><country key="FR"></country></address></desc><listRelation><relation active="#struct-300535" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-300535" type="direct"><org type="institution" xml:id="struct-300535" status="VALID"><orgName>CHU AMIENS</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Barbare, Jean Claude" sort="Barbare, Jean Claude" uniqKey="Barbare J" first="Jean Claude" last="Barbare">Jean Claude Barbare</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-101678" status="INCOMING"><orgName>Service d'Hépato-Gastroentérologie CH Compiègne</orgName><desc><address><addrLine>8 avenue Henri Adnot, Compiègne F-60200</addrLine><country key="FR"></country></address></desc><listRelation><relation active="#struct-324512" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-324512" type="direct"><org type="institution" xml:id="struct-324512" status="INCOMING"><orgName>CH COMPIEGNE</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Tramier, Blaise" sort="Tramier, Blaise" uniqKey="Tramier B" first="Blaise" last="Tramier">Blaise Tramier</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-101679" status="INCOMING"><orgName>Service de Biostatistiques</orgName><desc><address><addrLine>place Victor Pauchet, Amiens, F-80054 cedex 01</addrLine><country key="FR"></country></address></desc><listRelation><relation active="#struct-300535" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-300535" type="direct"><org type="institution" xml:id="struct-300535" status="VALID"><orgName>CHU AMIENS</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Dupas, Jean Louis" sort="Dupas, Jean Louis" uniqKey="Dupas J" first="Jean Louis" last="Dupas">Jean Louis Dupas</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-101666" status="INCOMING"><orgName>Service d'Hépato-Gastroentérologie</orgName><desc><address><addrLine>place Victor Pauchet, Amiens, F-80054 cedex 01</addrLine><country key="FR"></country></address></desc><listRelation><relation active="#struct-300535" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-300535" type="direct"><org type="institution" xml:id="struct-300535" status="VALID"><orgName>CHU AMIENS</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author></analytic><series><title level="j">Cancer Biology and Therapy</title><idno type="ISSN">1538-4047</idno><imprint><date type="datePub">2009-11</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">BACKGROUND: Somatostatin receptor scintigraphy (SRS) has been reported for receptor (SSTR) screening in advanced hepatocarcinoma (aHC) prior to somatostatin analogue treatment. AIMS: To evaluate SSTR screening with SRS in aHC patients. RESULTS: Seventy aHC patients (63 men) aged 65 +/- 11 y were included, with alcohol, viral or other causes cirrhosis in 35 (50%), 23 (33%), 12 (17%) cases respectively. CLIP score was 2.7 +/- 1.7, with more than three nodules in 37 (53%) cases. Largest nodule measured 7.6 +/- 4.5 cm. Median alpha-fetoprotein was 574 UI/mL. SRS was positive in 25/70 (35.7%) livers and 7/17 (41.2%) metastatic sites. Positive SRS patients differed from others for tumor size (9.2 +/- 4 vs. 6.7 +/- 4.6 cm, p = 0.03), prothrombin time (PT) (75.2 +/- 15.2 vs. 61.9 +/- 19%, p = 0.005), albumin (34.1 +/- 5.9 vs. 30.5 +/- 7.2 g/L, p = 0.04) and Child-Pugh (6.7 +/- 1.8 vs. 7.7 +/- 2.3, p = 0.04). After multivariate analysis, only PT was associated with positive SRS (p = 0.028). Immunohistochemistry was positive for SSTR2s in 6/7 tumors (SRS uptake in 5/6 cases). METHODS: SRS was performed prior treatment, with images at 4, 24 and 48 h. For seven tumors, SSTR2 subtype was detected immunohistochemically. CONCLUSIONS: In advanced hepatocarcinoma, we report SRS uptake in 35.7% of livers and 41.2% of metastatic sites. SRS value in screening patients for somatostatin analogue treatment remains to be assessed.</div></front></TEI><hal api="V3"><titleStmt><title xml:lang="en">Somatostatin receptor scintigraphy screening in advanced hepatocarcinoma: A multi-center French study.</title><author role="crp"><persName><forename type="first">Eric</forename><surname>Nguyen-Khac</surname></persName><email>nguyen-khac.eric@chu-amiens.fr</email><idno type="halauthor">435291</idno><affiliation ref="#struct-101666"></affiliation></author><author role="aut"><persName><forename type="first">Isabelle</forename><surname>Ollivier</surname></persName><email></email><idno type="halauthor">435292</idno><affiliation ref="#struct-101667"></affiliation></author><author role="aut"><persName><forename type="first">Thomas</forename><surname>Aparicio</surname></persName><email></email><idno type="halauthor">435293</idno><affiliation ref="#struct-51362"></affiliation></author><author role="aut"><persName><forename type="first">Véronique</forename><surname>Moullart</surname></persName><email></email><idno type="halauthor">435294</idno><affiliation ref="#struct-101669"></affiliation></author><author role="aut"><persName><forename type="first">Alexis</forename><surname>Hugentobler</surname></persName><email></email><idno type="halauthor">435295</idno><affiliation ref="#struct-101670"></affiliation></author><author role="aut"><persName><forename type="first">Rachida</forename><surname>Lebtahi</surname></persName><email></email><idno type="halauthor">435296</idno><affiliation ref="#struct-101671"></affiliation></author><author role="aut"><persName><forename type="first">Céline</forename><surname>Lobry</surname></persName><email></email><idno type="halauthor">435297</idno><affiliation ref="#struct-101666"></affiliation></author><author role="aut"><persName><forename type="first">Christiane</forename><surname>Susini</surname></persName><email></email><idno type="halauthor">425910</idno><affiliation ref="#struct-2893"></affiliation></author><author role="aut"><persName><forename type="first">Christian</forename><surname>Duhamel</surname></persName><email></email><idno type="halauthor">435298</idno><affiliation ref="#struct-101674"></affiliation></author><author role="aut"><persName><forename type="first">Séverine</forename><surname>Hommel</surname></persName><email></email><idno type="halauthor">435299</idno><affiliation ref="#struct-95536"></affiliation></author><author role="aut"><persName><forename type="first">Jean François</forename><surname>Cadranel</surname></persName><email></email><idno type="halauthor">435300</idno><affiliation ref="#struct-101676"></affiliation></author><author role="aut"><persName><forename type="first">Jean-Paul</forename><surname>Joly</surname></persName><email></email><idno type="halauthor">435301</idno><affiliation ref="#struct-101666"></affiliation></author><author role="aut"><persName><forename type="first">Jean Claude</forename><surname>Barbare</surname></persName><email></email><idno type="halauthor">435302</idno><affiliation ref="#struct-101678"></affiliation></author><author role="aut"><persName><forename type="first">Blaise</forename><surname>Tramier</surname></persName><email></email><idno type="halauthor">435303</idno><affiliation ref="#struct-101679"></affiliation></author><author role="aut"><persName><forename type="first">Jean Louis</forename><surname>Dupas</surname></persName><email></email><idno type="halauthor">435304</idno><affiliation ref="#struct-101666"></affiliation></author><editor role="depositor"><persName><forename>Marie Francoise</forename><surname>Simon</surname></persName><email>jerome.daguzan@inserm.fr</email></editor></titleStmt><editionStmt><edition n="v1" type="current"><date type="whenSubmitted">2009-09-24 10:41:10</date><date type="whenModified">2016-10-11 14:46:08</date><date type="whenReleased">2009-09-25 09:45:25</date><date type="whenProduced">2009-11</date></edition><respStmt><resp>contributor</resp><name key="118088"><persName><forename>Marie Francoise</forename><surname>Simon</surname></persName><email>jerome.daguzan@inserm.fr</email></name></respStmt></editionStmt><publicationStmt><distributor>CCSD</distributor><idno type="halId">inserm-00419507</idno><idno type="halUri">http://www.hal.inserm.fr/inserm-00419507</idno><idno type="halBibtex">nguyenkhac:inserm-00419507</idno><idno type="halRefHtml">Cancer Biology and Therapy, Taylor & Francis, 2009, 8 (21), pp.2033-9</idno><idno type="halRef">Cancer Biology and Therapy, Taylor & Francis, 2009, 8 (21), pp.2033-9</idno></publicationStmt><seriesStmt><idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno><idno type="stamp" n="UNIV-TLSE3">Université Paul Sabatier - Toulouse III</idno><idno type="stamp" n="APHP" p="INSERM">AP-HP</idno><idno type="stamp" n="UNIV-PARIS7">Université Denis Diderot - Paris VII</idno><idno type="stamp" n="USPC">Université Sorbonne Paris Cité</idno></seriesStmt><notesStmt><note type="audience" n="2">International</note><note type="popular" n="0">No</note><note type="peer" n="1">Yes</note></notesStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Somatostatin receptor scintigraphy screening in advanced hepatocarcinoma: A multi-center French study.</title><author role="crp"><persName><forename type="first">Eric</forename><surname>Nguyen-Khac</surname></persName><email>nguyen-khac.eric@chu-amiens.fr</email><idno type="halAuthorId">435291</idno><affiliation ref="#struct-101666"></affiliation></author><author role="aut"><persName><forename type="first">Isabelle</forename><surname>Ollivier</surname></persName><idno type="halAuthorId">435292</idno><affiliation ref="#struct-101667"></affiliation></author><author role="aut"><persName><forename type="first">Thomas</forename><surname>Aparicio</surname></persName><idno type="halAuthorId">435293</idno><affiliation ref="#struct-51362"></affiliation></author><author role="aut"><persName><forename type="first">Véronique</forename><surname>Moullart</surname></persName><idno type="halAuthorId">435294</idno><affiliation ref="#struct-101669"></affiliation></author><author role="aut"><persName><forename type="first">Alexis</forename><surname>Hugentobler</surname></persName><idno type="halAuthorId">435295</idno><affiliation ref="#struct-101670"></affiliation></author><author role="aut"><persName><forename type="first">Rachida</forename><surname>Lebtahi</surname></persName><idno type="halAuthorId">435296</idno><affiliation ref="#struct-101671"></affiliation></author><author role="aut"><persName><forename type="first">Céline</forename><surname>Lobry</surname></persName><idno type="halAuthorId">435297</idno><affiliation ref="#struct-101666"></affiliation></author><author role="aut"><persName><forename type="first">Christiane</forename><surname>Susini</surname></persName><idno type="halAuthorId">425910</idno><affiliation ref="#struct-2893"></affiliation></author><author role="aut"><persName><forename type="first">Christian</forename><surname>Duhamel</surname></persName><idno type="halAuthorId">435298</idno><affiliation ref="#struct-101674"></affiliation></author><author role="aut"><persName><forename type="first">Séverine</forename><surname>Hommel</surname></persName><idno type="halAuthorId">435299</idno><affiliation ref="#struct-95536"></affiliation></author><author role="aut"><persName><forename type="first">Jean François</forename><surname>Cadranel</surname></persName><idno type="halAuthorId">435300</idno><affiliation ref="#struct-101676"></affiliation></author><author role="aut"><persName><forename type="first">Jean-Paul</forename><surname>Joly</surname></persName><idno type="halAuthorId">435301</idno><affiliation ref="#struct-101666"></affiliation></author><author role="aut"><persName><forename type="first">Jean Claude</forename><surname>Barbare</surname></persName><idno type="halAuthorId">435302</idno><affiliation ref="#struct-101678"></affiliation></author><author role="aut"><persName><forename type="first">Blaise</forename><surname>Tramier</surname></persName><idno type="halAuthorId">435303</idno><affiliation ref="#struct-101679"></affiliation></author><author role="aut"><persName><forename type="first">Jean Louis</forename><surname>Dupas</surname></persName><idno type="halAuthorId">435304</idno><affiliation ref="#struct-101666"></affiliation></author></analytic><monogr><idno type="halJournalId" status="VALID">22510</idno><idno type="issn">1538-4047</idno><title level="j">Cancer Biology and Therapy</title><imprint><publisher>Taylor & Francis</publisher><biblScope unit="volume">8</biblScope><biblScope unit="issue">21</biblScope><biblScope unit="pp">2033-9</biblScope><date type="datePub">2009-11</date><date type="dateEpub">2009-11-05</date></imprint></monogr><idno type="pubmed">19738430</idno></biblStruct></sourceDesc><profileDesc><langUsage><language ident="en">English</language></langUsage><textClass><classCode scheme="halDomain" n="sdv.bbm">Life Sciences [q-bio]/Biochemistry, Molecular Biology</classCode><classCode scheme="halTypology" n="ART">Journal articles</classCode></textClass><abstract xml:lang="en">BACKGROUND: Somatostatin receptor scintigraphy (SRS) has been reported for receptor (SSTR) screening in advanced hepatocarcinoma (aHC) prior to somatostatin analogue treatment. AIMS: To evaluate SSTR screening with SRS in aHC patients. RESULTS: Seventy aHC patients (63 men) aged 65 +/- 11 y were included, with alcohol, viral or other causes cirrhosis in 35 (50%), 23 (33%), 12 (17%) cases respectively. CLIP score was 2.7 +/- 1.7, with more than three nodules in 37 (53%) cases. Largest nodule measured 7.6 +/- 4.5 cm. Median alpha-fetoprotein was 574 UI/mL. SRS was positive in 25/70 (35.7%) livers and 7/17 (41.2%) metastatic sites. Positive SRS patients differed from others for tumor size (9.2 +/- 4 vs. 6.7 +/- 4.6 cm, p = 0.03), prothrombin time (PT) (75.2 +/- 15.2 vs. 61.9 +/- 19%, p = 0.005), albumin (34.1 +/- 5.9 vs. 30.5 +/- 7.2 g/L, p = 0.04) and Child-Pugh (6.7 +/- 1.8 vs. 7.7 +/- 2.3, p = 0.04). After multivariate analysis, only PT was associated with positive SRS (p = 0.028). Immunohistochemistry was positive for SSTR2s in 6/7 tumors (SRS uptake in 5/6 cases). METHODS: SRS was performed prior treatment, with images at 4, 24 and 48 h. For seven tumors, SSTR2 subtype was detected immunohistochemically. CONCLUSIONS: In advanced hepatocarcinoma, we report SRS uptake in 35.7% of livers and 41.2% of metastatic sites. SRS value in screening patients for somatostatin analogue treatment remains to be assessed.</abstract></profileDesc></hal></record>Pour manipuler ce document sous Unix (Dilib)
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