Different Modalities of Intercellular Membrane Exchanges Mediate Cell-to-cell P-glycoprotein Transfers in MCF-7 Breast Cancer Cells*
Identifieur interne : 000570 ( France/Extraction ); précédent : 000569; suivant : 000571Different Modalities of Intercellular Membrane Exchanges Mediate Cell-to-cell P-glycoprotein Transfers in MCF-7 Breast Cancer Cells*
Auteurs : Jennifer Pasquier [France] ; Ludovic Galas [France] ; Céline Boulangé-Lecomte ; Damien Rioult ; Florence Bultelle ; Pierre Magal [France] ; Glenn Webb ; Frank Le FollSource :
- The Journal of Biological Chemistry [ 0021-9258 ] ; 2012.
English descriptors
- KwdEn :
- Breast Neoplasms (genetics), Breast Neoplasms (metabolism), Breast Neoplasms (pathology), Cell Communication, Cell Line, Tumor, Cell-Derived Microparticles (genetics), Cell-Derived Microparticles (metabolism), Cell-Derived Microparticles (pathology), Drug Resistance, Neoplasm, Female, Humans, P-Glycoprotein (genetics), P-Glycoprotein (metabolism), Protein Transport (genetics).
- MESH :
- chemical , genetics : P-Glycoprotein.
- genetics : Breast Neoplasms, Cell-Derived Microparticles, Protein Transport.
- metabolism : Breast Neoplasms, Cell-Derived Microparticles, P-Glycoprotein.
- pathology : Breast Neoplasms, Cell-Derived Microparticles.
- Cell Communication, Cell Line, Tumor, Drug Resistance, Neoplasm, Female, Humans.
Abstract
Url:
DOI: 10.1074/jbc.M111.312157
PubMed: 22228759
PubMed Central: 3293537
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PMC:3293537Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Different Modalities of Intercellular Membrane Exchanges Mediate Cell-to-cell P-glycoprotein Transfers in MCF-7 Breast Cancer Cells<xref ref-type="fn" rid="FN1">*</xref>
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<series><title level="j">The Journal of Biological Chemistry</title>
<idno type="ISSN">0021-9258</idno>
<idno type="eISSN">1083-351X</idno>
<imprint><date when="2012">2012</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Breast Neoplasms (genetics)</term>
<term>Breast Neoplasms (metabolism)</term>
<term>Breast Neoplasms (pathology)</term>
<term>Cell Communication</term>
<term>Cell Line, Tumor</term>
<term>Cell-Derived Microparticles (genetics)</term>
<term>Cell-Derived Microparticles (metabolism)</term>
<term>Cell-Derived Microparticles (pathology)</term>
<term>Drug Resistance, Neoplasm</term>
<term>Female</term>
<term>Humans</term>
<term>P-Glycoprotein (genetics)</term>
<term>P-Glycoprotein (metabolism)</term>
<term>Protein Transport (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>P-Glycoprotein</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Breast Neoplasms</term>
<term>Cell-Derived Microparticles</term>
<term>Protein Transport</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Breast Neoplasms</term>
<term>Cell-Derived Microparticles</term>
<term>P-Glycoprotein</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term>
<term>Cell-Derived Microparticles</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Cell Communication</term>
<term>Cell Line, Tumor</term>
<term>Drug Resistance, Neoplasm</term>
<term>Female</term>
<term>Humans</term>
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<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
The P-glycoprotein is expressed in many human cancers, where it contributes to multi-drug resistance phenomenon.</p>
<p><bold>Results:</bold>
Both TnTs and microparticles contribute to the transfer of P-gp in MCF-7.</p>
<p><bold>Conclusion:</bold>
Our findings supply new mechanistic evidences for the extragenetic emergence of MDR in cancer cells.</p>
<p><bold>Significance:</bold>
Inhibition of both MPs and TnTs could be included in treatment strategies designed to overcome MDR.</p>
</div>
</front>
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