Antibiotic susceptibility in aerobic gram-negative bacilli isolated in intensive care units in 39 French teaching hospitals (ICU study)
Identifieur interne : 001373 ( France/Analysis ); précédent : 001372; suivant : 001374Antibiotic susceptibility in aerobic gram-negative bacilli isolated in intensive care units in 39 French teaching hospitals (ICU study)
Auteurs : V. Jarlier [France] ; T. Fosse [France] ; A. Philippon [France]Source :
- Intensive Care Medicine [ 0342-4642 ] ; 1996-10-01.
Abstract
Abstract: Objective: Evaluation of the distribution and antibiotic susceptibility of the aerobic gramnegative bacilli (AGNB) isolated from patients in intensive care units (ICU study). Design and setting: Microbiological study carried out in 1991 in 39 teaching hospitals. A standardized method was used to determine the minimum inhibitory concentrations of 12 antibiotics against 3366 strains of AGNB (close to 100 strains per hospital) during a period of 3 months. Results: The 2773 initial strains (i.e., the first AGNB isolate for a given species and a given patient) were mainly isolated from the respiratory tract (34.4%), urinary tract (23%), or blood (9.6%) and were mainlyPseudomonas aeruginosa (22.9%),Escherichia coli (22%), Acinetobacter (9.7%), andKlebsiella pneumoniae (8.3%).E. coli was prominent in urine and blood andP. aeruginosa in the respiratory tract. Overall, the rate of susceptibility of AGNB was 58 to 65% to piperacillin, cefotaxime, and gentamicin; 69 to 75% to aztreonam, tobramycin, and ciprofloxacin; 83% to ceftazidime; and 91% to imipenem. The overall rates of susceptibility were higher for the initial strains isolated from blood than for those from the urinary or respiratory tracts, mostly reflecting differences in species distribution. Susceptibility rates were lower for the 593 repeat strains (i.e., all the subsequent isolates for a given species and a given patient) than for the initial strains, mostly due to the higher proportion of resistant species (P. aeruginosa 45.9%) but also due to the difference in susceptibility rates for some species-antibiotic combinations. Concomitant resistance (i.e., resistance to several antibiotics due to independent mechanisms of resistance) was marked between β-lactams and aminoglycosides or quinolones, particularly inP. aeruginosa andK. pneumoniae. Conclusions: Rates of resistance in AGNB as a whole and in particular species (P. aeruginosa, Klebsiella), as well as frequency of concomitant resistance found in the French ICU study, were higher than those found in ICU studies conducted with the same methodology in Belgium, The Netherlands, and Germany, which may reflect differences in case mix.
Url:
DOI: 10.1007/BF01699228
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001725
- to stream Istex, to step Curation: 001725
- to stream Istex, to step Checkpoint: 000E51
- to stream Main, to step Merge: 001F93
- to stream Main, to step Curation: 001F37
- to stream Main, to step Exploration: 001F37
- to stream France, to step Extraction: 001373
Links to Exploration step
ISTEX:09447956444C8F00343BBA340AEF9BF90B255271Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antibiotic susceptibility in aerobic gram-negative bacilli isolated in intensive care units in 39 French teaching hospitals (ICU study)</title><author><name sortKey="Jarlier, V" sort="Jarlier, V" uniqKey="Jarlier V" first="V." last="Jarlier">V. Jarlier</name></author><author><name sortKey="Fosse, T" sort="Fosse, T" uniqKey="Fosse T" first="T." last="Fosse">T. Fosse</name></author><author><name sortKey="Philippon, A" sort="Philippon, A" uniqKey="Philippon A" first="A." last="Philippon">A. Philippon</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:09447956444C8F00343BBA340AEF9BF90B255271</idno><date when="1996" year="1996">1996</date><idno type="doi">10.1007/BF01699228</idno><idno type="url">https://api.istex.fr/document/09447956444C8F00343BBA340AEF9BF90B255271/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001725</idno><idno type="wicri:Area/Istex/Curation">001725</idno><idno type="wicri:Area/Istex/Checkpoint">000E51</idno><idno type="wicri:doubleKey">0342-4642:1996:Jarlier V:antibiotic:susceptibility:in</idno><idno type="wicri:Area/Main/Merge">001F93</idno><idno type="wicri:Area/Main/Curation">001F37</idno><idno type="wicri:Area/Main/Exploration">001F37</idno><idno type="wicri:Area/France/Extraction">001373</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Antibiotic susceptibility in aerobic gram-negative bacilli isolated in intensive care units in 39 French teaching hospitals (ICU study)</title><author><name sortKey="Jarlier, V" sort="Jarlier, V" uniqKey="Jarlier V" first="V." last="Jarlier">V. Jarlier</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Bactériologie, Hôpital Pitié-Salpêtrière, 47 boulevard de l'Hôpital, F-75651, Paris cedex 13</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Fosse, T" sort="Fosse, T" uniqKey="Fosse T" first="T." last="Fosse">T. Fosse</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Bactériologie, Hôpital Pasteur, 30 rue de la Voie Romaine, F-06000, Nice</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Philippon, A" sort="Philippon, A" uniqKey="Philippon A" first="A." last="Philippon">A. Philippon</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Bactériologie, Hôpital saint-Louis, 1 avenue Claude Vellefaux, F-75010, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Intensive Care Medicine</title><title level="j" type="abbrev">Intensive Care Med</title><idno type="ISSN">0342-4642</idno><idno type="eISSN">1432-1238</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1996-10-01">1996-10-01</date><biblScope unit="volume">22</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1057">1057</biblScope><biblScope unit="page" to="1065">1065</biblScope></imprint><idno type="ISSN">0342-4642</idno></series><idno type="istex">09447956444C8F00343BBA340AEF9BF90B255271</idno><idno type="DOI">10.1007/BF01699228</idno><idno type="ArticleID">BF01699228</idno><idno type="ArticleID">Art11</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0342-4642</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Objective: Evaluation of the distribution and antibiotic susceptibility of the aerobic gramnegative bacilli (AGNB) isolated from patients in intensive care units (ICU study). Design and setting: Microbiological study carried out in 1991 in 39 teaching hospitals. A standardized method was used to determine the minimum inhibitory concentrations of 12 antibiotics against 3366 strains of AGNB (close to 100 strains per hospital) during a period of 3 months. Results: The 2773 initial strains (i.e., the first AGNB isolate for a given species and a given patient) were mainly isolated from the respiratory tract (34.4%), urinary tract (23%), or blood (9.6%) and were mainlyPseudomonas aeruginosa (22.9%),Escherichia coli (22%), Acinetobacter (9.7%), andKlebsiella pneumoniae (8.3%).E. coli was prominent in urine and blood andP. aeruginosa in the respiratory tract. Overall, the rate of susceptibility of AGNB was 58 to 65% to piperacillin, cefotaxime, and gentamicin; 69 to 75% to aztreonam, tobramycin, and ciprofloxacin; 83% to ceftazidime; and 91% to imipenem. The overall rates of susceptibility were higher for the initial strains isolated from blood than for those from the urinary or respiratory tracts, mostly reflecting differences in species distribution. Susceptibility rates were lower for the 593 repeat strains (i.e., all the subsequent isolates for a given species and a given patient) than for the initial strains, mostly due to the higher proportion of resistant species (P. aeruginosa 45.9%) but also due to the difference in susceptibility rates for some species-antibiotic combinations. Concomitant resistance (i.e., resistance to several antibiotics due to independent mechanisms of resistance) was marked between β-lactams and aminoglycosides or quinolones, particularly inP. aeruginosa andK. pneumoniae. Conclusions: Rates of resistance in AGNB as a whole and in particular species (P. aeruginosa, Klebsiella), as well as frequency of concomitant resistance found in the French ICU study, were higher than those found in ICU studies conducted with the same methodology in Belgium, The Netherlands, and Germany, which may reflect differences in case mix.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Provence-Alpes-Côte d'Azur</li><li>Île-de-France</li></region><settlement><li>Nice</li><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Jarlier, V" sort="Jarlier, V" uniqKey="Jarlier V" first="V." last="Jarlier">V. Jarlier</name></region><name sortKey="Fosse, T" sort="Fosse, T" uniqKey="Fosse T" first="T." last="Fosse">T. Fosse</name><name sortKey="Philippon, A" sort="Philippon, A" uniqKey="Philippon A" first="A." last="Philippon">A. Philippon</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/France/explor/LeHavreV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001373 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 001373 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/France
|area= LeHavreV1
|flux= France
|étape= Analysis
|type= RBID
|clé= ISTEX:09447956444C8F00343BBA340AEF9BF90B255271
|texte= Antibiotic susceptibility in aerobic gram-negative bacilli isolated in intensive care units in 39 French teaching hospitals (ICU study)
}}
| This area was generated with Dilib version V0.6.25. |  |