[Fetal death beyond 14 weeks of gestation: induction of labor and obtaining of uterine vacuity].
Identifieur interne : 000141 ( France/Analysis ); précédent : 000140; suivant : 000142[Fetal death beyond 14 weeks of gestation: induction of labor and obtaining of uterine vacuity].
Auteurs : G. Beucher [France] ; P. Dolley [France] ; Z. Stewart [France] ; G. Carles ; E. Grossetti [France] ; M. Dreyfus [France]Source :
- Gynecologie, obstetrique & fertilite [ 1769-6682 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Misoprostol, Oxytocics.
- Female, Fetal Death, Humans, Labor, Induced, Pregnancy, Pregnancy Trimester, Second, Pregnancy Trimester, Third.
Abstract
The objective of this review was to assess benefits and harms of different management options for induction of labor and obtaining of uterine vacuity in case of fetal death beyond of 14 weeks of gestation. In second-trimester, the data are numerous but low methodological quality. In terms of efficiency (induction-expulsion time and uterine evacuation within 24 hours rate) and tolerance in the absence of antecedent of caesarean section, the best protocol for induction of labor in the second-trimester of pregnancy appears to be mifepristone 200mg orally followed 24-48 hours later by vaginal administration of misoprostol 200 to 400 μg every 4 to 6 hours. In third-trimester, there is very little data. The circumstances are similar to induction of labor with living fetus. A term or near term, oxytocin and dinoprostone have a marketing authorization in this indication but misoprostol may be an alternative as the Bishop score and dose of induction of labor with living fetus. In case of previous caesarean section, the risk of uterine rupture is increased in case of a medical induction of labor with prostaglandins. The lowest effective doses should be used (100 to 200 μg every 4 to 6 hours). Prior cervical preparation by the administration of mifepristone and possibly the use of laminar seems essential in this situation.
DOI: 10.1016/j.gyobfe.2014.11.008
PubMed: 25511016
Affiliations:
- France
- Basse-Normandie, Haute-Normandie, Région Normandie
- Caen, Le Havre
- Université de Caen Basse-Normandie
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000108
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- to stream PubMed, to step Checkpoint: 000108
- to stream Ncbi, to step Merge: 000449
- to stream Ncbi, to step Curation: 000449
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- to stream Main, to step Curation: 000144
- to stream Main, to step Exploration: 000144
- to stream France, to step Extraction: 000141
Links to Exploration step
pubmed:25511016Le document en format XML
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<front><div type="abstract" xml:lang="en">The objective of this review was to assess benefits and harms of different management options for induction of labor and obtaining of uterine vacuity in case of fetal death beyond of 14 weeks of gestation. In second-trimester, the data are numerous but low methodological quality. In terms of efficiency (induction-expulsion time and uterine evacuation within 24 hours rate) and tolerance in the absence of antecedent of caesarean section, the best protocol for induction of labor in the second-trimester of pregnancy appears to be mifepristone 200mg orally followed 24-48 hours later by vaginal administration of misoprostol 200 to 400 μg every 4 to 6 hours. In third-trimester, there is very little data. The circumstances are similar to induction of labor with living fetus. A term or near term, oxytocin and dinoprostone have a marketing authorization in this indication but misoprostol may be an alternative as the Bishop score and dose of induction of labor with living fetus. In case of previous caesarean section, the risk of uterine rupture is increased in case of a medical induction of labor with prostaglandins. The lowest effective doses should be used (100 to 200 μg every 4 to 6 hours). Prior cervical preparation by the administration of mifepristone and possibly the use of laminar seems essential in this situation.</div>
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<name sortKey="Dolley, P" sort="Dolley, P" uniqKey="Dolley P" first="P" last="Dolley">P. Dolley</name>
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<name sortKey="Grossetti, E" sort="Grossetti, E" uniqKey="Grossetti E" first="E" last="Grossetti">E. Grossetti</name>
<name sortKey="Stewart, Z" sort="Stewart, Z" uniqKey="Stewart Z" first="Z" last="Stewart">Z. Stewart</name>
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