AustralieFrV1, PubMed, Curation, bibRecord, 003846

Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease.

Identifieur interne : 003846 ( PubMed/Curation ); précédent : 003845; suivant : 003847

Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease.

Auteurs : Helena Gylling [Finlande] ; Jogchum Plat [Pays-Bas] ; Stephen Turley [États-Unis] ; Henry N. Ginsberg [États-Unis] ; Lars Elleg Rd [Suède] ; Wendy Jessup [Australie] ; Peter J. Jones [Canada] ; Dieter Lütjohann [Allemagne] ; Winfried Maerz [Autriche] ; Luis Masana [Espagne] ; Günther Silbernagel [Suisse] ; Bart Staels [France] ; Jan Borén [Suède] ; Alberico L. Catapano [Italie] ; Guy De Backer [Belgique] ; John Deanfield [Royaume-Uni] ; Olivier S. Descamps [Belgique] ; Petri T. Kovanen [Finlande] ; Gabriele Riccardi [Italie] ; Lale Tokgözoglu [Turquie] ; M John Chapman [France]

Source :

Atherosclerosis [ 1879-1484 ] ; 2014.

RBID : pubmed:24468148

Descripteurs français

KwdFr :
- Animaux, Anticholestérolémiants (usage thérapeutique), Cholestérol (métabolisme), Cholestérol (sang), Cholestérol LDL (sang), Dyslipidémies (), Humains, Inflammation (traitement médicamenteux), Lipides (sang), Maladies cardiovasculaires (), Maladies cardiovasculaires (sang), Phytostérols (usage thérapeutique), Sitostérol (usage thérapeutique), Triglycéride (sang).
MESH :
- métabolisme : Cholestérol.
- sang : Cholestérol, Cholestérol LDL, Lipides, Maladies cardiovasculaires, Triglycéride.
- traitement médicamenteux : Inflammation.
- usage thérapeutique : Anticholestérolémiants, Phytostérols, Sitostérol.
- Animaux, Dyslipidémies, Humains, Maladies cardiovasculaires.

English descriptors

KwdEn :
- Animals, Anticholesteremic Agents (therapeutic use), Cardiovascular Diseases (blood), Cardiovascular Diseases (prevention & control), Cardiovascular Diseases (therapy), Cholesterol (blood), Cholesterol (metabolism), Cholesterol, LDL (blood), Dyslipidemias (therapy), Humans, Inflammation (drug therapy), Lipids (blood), Phytosterols (therapeutic use), Sitosterols (therapeutic use), Triglycerides (blood).
MESH :
- chemical , blood : Cholesterol, Cholesterol, LDL, Lipids, Triglycerides.
- chemical , metabolism : Cholesterol.
- chemical , therapeutic use : Anticholesteremic Agents, Phytosterols, Sitosterols.
- blood : Cardiovascular Diseases.
- drug therapy : Inflammation.
- prevention & control : Cardiovascular Diseases.
- therapy : Cardiovascular Diseases, Dyslipidemias.
- Animals, Humans.

Abstract

This EAS Consensus Panel critically appraised evidence relevant to the benefit to risk relationship of functional foods with added plant sterols and/or plant stanols, as components of a healthy lifestyle, to reduce plasma low-density lipoprotein-cholesterol (LDL-C) levels, and thereby lower cardiovascular risk.

DOI: 10.1016/j.atherosclerosis.2013.11.043
PubMed: 24468148

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Le document en format XML

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<author><name sortKey="Masana, Luis" sort="Masana, Luis" uniqKey="Masana L" first="Luis" last="Masana">Luis Masana</name>
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<author><name sortKey="Silbernagel, Gunther" sort="Silbernagel, Gunther" uniqKey="Silbernagel G" first="Günther" last="Silbernagel">Günther Silbernagel</name>
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<wicri:regionArea>Department of Angiology, Swiss Cardiovascular Center, Inselspital, University of Bern</wicri:regionArea>
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<author><name sortKey="Staels, Bart" sort="Staels, Bart" uniqKey="Staels B" first="Bart" last="Staels">Bart Staels</name>
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<wicri:regionArea>Faculty of Pharmacy, University of Lille 2, Lille</wicri:regionArea>
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<author><name sortKey="Boren, Jan" sort="Boren, Jan" uniqKey="Boren J" first="Jan" last="Borén">Jan Borén</name>
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<country xml:lang="fr">Suède</country>
<wicri:regionArea>Strategic Research Center, Sahlgrenska Center for Cardiovascular and Metabolic Research (CMR), University of Gothenburg</wicri:regionArea>
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<author><name sortKey="Catapano, Alberico L" sort="Catapano, Alberico L" uniqKey="Catapano A" first="Alberico L" last="Catapano">Alberico L. Catapano</name>
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<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Pharmacological and Biomolecular Sciences, University of Milan, Italy; Multimedica IRCSS Milano</wicri:regionArea>
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<author><name sortKey="De Backer, Guy" sort="De Backer, Guy" uniqKey="De Backer G" first="Guy" last="De Backer">Guy De Backer</name>
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<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Public Health, University Hospital Ghent, Ghent</wicri:regionArea>
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<author><name sortKey="Deanfield, John" sort="Deanfield, John" uniqKey="Deanfield J" first="John" last="Deanfield">John Deanfield</name>
<affiliation wicri:level="1"><nlm:affiliation>National Centre for Cardiovascular Prevention and Outcomes, University College London, UK. Electronic address: john.deanfield@gmail.com.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>National Centre for Cardiovascular Prevention and Outcomes, University College London</wicri:regionArea>
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<author><name sortKey="Descamps, Olivier S" sort="Descamps, Olivier S" uniqKey="Descamps O" first="Olivier S" last="Descamps">Olivier S. Descamps</name>
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<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Lipid Clinic, Hopital de Jolimont, Haine-Saint-Paul</wicri:regionArea>
</affiliation>
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<author><name sortKey="Kovanen, Petri T" sort="Kovanen, Petri T" uniqKey="Kovanen P" first="Petri T" last="Kovanen">Petri T. Kovanen</name>
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<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Wihuri Research Institute, Helsinki</wicri:regionArea>
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<author><name sortKey="Riccardi, Gabriele" sort="Riccardi, Gabriele" uniqKey="Riccardi G" first="Gabriele" last="Riccardi">Gabriele Riccardi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy. Electronic address: riccardi@unina.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Clinical and Experimental Medicine, Federico II University, Naples</wicri:regionArea>
</affiliation>
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<author><name sortKey="Tokgozoglu, Lale" sort="Tokgozoglu, Lale" uniqKey="Tokgozoglu L" first="Lale" last="Tokgözoglu">Lale Tokgözoglu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Hacettepe University, Ankara, Turkey. Electronic address: lalet@hacettepe.edu.tr.</nlm:affiliation>
<country xml:lang="fr">Turquie</country>
<wicri:regionArea>Department of Cardiology, Hacettepe University, Ankara</wicri:regionArea>
</affiliation>
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<author><name sortKey="Chapman, M John" sort="Chapman, M John" uniqKey="Chapman M" first="M John" last="Chapman">M John Chapman</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Pierre and Marie Curie, Paris, France; Dyslipidaemia and Atherosclerosis Research Unit, INSERM U939, Pitié-Salpetriere University Hospital, Paris, France. Electronic address: john.chapman@upmc.fr.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>University of Pierre and Marie Curie, Paris, France; Dyslipidaemia and Atherosclerosis Research Unit, INSERM U939, Pitié-Salpetriere University Hospital, Paris</wicri:regionArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease.</title>
<author><name sortKey="Gylling, Helena" sort="Gylling, Helena" uniqKey="Gylling H" first="Helena" last="Gylling">Helena Gylling</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Division of Internal Medicine, University of Helsinki, Biomedicum Helsinki, Finland. Electronic address: Helena.Gylling@hus.fi.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Medicine, Division of Internal Medicine, University of Helsinki, Biomedicum Helsinki</wicri:regionArea>
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<author><name sortKey="Plat, Jogchum" sort="Plat, Jogchum" uniqKey="Plat J" first="Jogchum" last="Plat">Jogchum Plat</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Human Biology, Maastricht University, The Netherlands. Electronic address: j.plat@maastrichtuniversity.nl.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Human Biology, Maastricht University</wicri:regionArea>
</affiliation>
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<author><name sortKey="Turley, Stephen" sort="Turley, Stephen" uniqKey="Turley S" first="Stephen" last="Turley">Stephen Turley</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, UT Southwestern Medical Center, Dallas, USA. Electronic address: Stephen.Turley@UTSouthwestern.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Internal Medicine, UT Southwestern Medical Center, Dallas</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ginsberg, Henry N" sort="Ginsberg, Henry N" uniqKey="Ginsberg H" first="Henry N" last="Ginsberg">Henry N. Ginsberg</name>
<affiliation wicri:level="1"><nlm:affiliation>Irving Institute for Clinical and Translational Research, Columbia University, New York, USA. Electronic address: hng1@columbia.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Irving Institute for Clinical and Translational Research, Columbia University, New York</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Elleg Rd, Lars" sort="Elleg Rd, Lars" uniqKey="Elleg Rd L" first="Lars" last="Elleg Rd">Lars Elleg Rd</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy at University of Gothenburg, Sweden. Electronic address: lasse.ellegard@nutrition.gu.se.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy at University of Gothenburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jessup, Wendy" sort="Jessup, Wendy" uniqKey="Jessup W" first="Wendy" last="Jessup">Wendy Jessup</name>
<affiliation wicri:level="1"><nlm:affiliation>ANZAC Research Institute, Concord Hospital, Sydney, Australia. Electronic address: wendy.jessup@gmail.com.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>ANZAC Research Institute, Concord Hospital, Sydney</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jones, Peter J" sort="Jones, Peter J" uniqKey="Jones P" first="Peter J" last="Jones">Peter J. Jones</name>
<affiliation wicri:level="1"><nlm:affiliation>Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Canada. Electronic address: Peter.Jones@umanitoba.ca.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lutjohann, Dieter" sort="Lutjohann, Dieter" uniqKey="Lutjohann D" first="Dieter" last="Lütjohann">Dieter Lütjohann</name>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Clinical Chemistry and Clinical Pharmacology, University Clinics Bonn</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Maerz, Winfried" sort="Maerz, Winfried" uniqKey="Maerz W" first="Winfried" last="Maerz">Winfried Maerz</name>
<affiliation wicri:level="1"><nlm:affiliation>Synlab Academy, Synlab LLC, Mannheim Center of Laboratory Diagnostics, Heidelberg, Germany; Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty Mannheim, University of Heidelberg, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria. Electronic address: Winfried.Maerz@synlab.com.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Synlab Academy, Synlab LLC, Mannheim Center of Laboratory Diagnostics, Heidelberg, Germany; Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty Mannheim, University of Heidelberg, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Masana, Luis" sort="Masana, Luis" uniqKey="Masana L" first="Luis" last="Masana">Luis Masana</name>
<affiliation wicri:level="1"><nlm:affiliation>Vascular Medicine and Metabolism Unit, University Hospital Sant Joan, IISPV, CIBERDEM, Rovira and Virgili University, Reus, Spain. Electronic address: luis.masana@urv.cat.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Vascular Medicine and Metabolism Unit, University Hospital Sant Joan, IISPV, CIBERDEM, Rovira and Virgili University, Reus</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Silbernagel, Gunther" sort="Silbernagel, Gunther" uniqKey="Silbernagel G" first="Günther" last="Silbernagel">Günther Silbernagel</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Angiology, Swiss Cardiovascular Center, Inselspital, University of Bern, Switzerland. Electronic address: guenther.silbernagel@yahoo.com.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Angiology, Swiss Cardiovascular Center, Inselspital, University of Bern</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Staels, Bart" sort="Staels, Bart" uniqKey="Staels B" first="Bart" last="Staels">Bart Staels</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Pharmacy, University of Lille 2, Lille, France. Electronic address: Bart.Staels@pasteur-lille.fr.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Faculty of Pharmacy, University of Lille 2, Lille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Boren, Jan" sort="Boren, Jan" uniqKey="Boren J" first="Jan" last="Borén">Jan Borén</name>
<affiliation wicri:level="1"><nlm:affiliation>Strategic Research Center, Sahlgrenska Center for Cardiovascular and Metabolic Research (CMR), University of Gothenburg, Sweden. Electronic address: Jan.Boren@wlab.gu.se.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Strategic Research Center, Sahlgrenska Center for Cardiovascular and Metabolic Research (CMR), University of Gothenburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Catapano, Alberico L" sort="Catapano, Alberico L" uniqKey="Catapano A" first="Alberico L" last="Catapano">Alberico L. Catapano</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacological and Biomolecular Sciences, University of Milan, Italy; Multimedica IRCSS Milano, Italy. Electronic address: alberico.catapano@unimi.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Pharmacological and Biomolecular Sciences, University of Milan, Italy; Multimedica IRCSS Milano</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De Backer, Guy" sort="De Backer, Guy" uniqKey="De Backer G" first="Guy" last="De Backer">Guy De Backer</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Public Health, University Hospital Ghent, Ghent, Belgium. Electronic address: guy.debacker@ugent.be.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Public Health, University Hospital Ghent, Ghent</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Deanfield, John" sort="Deanfield, John" uniqKey="Deanfield J" first="John" last="Deanfield">John Deanfield</name>
<affiliation wicri:level="1"><nlm:affiliation>National Centre for Cardiovascular Prevention and Outcomes, University College London, UK. Electronic address: john.deanfield@gmail.com.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>National Centre for Cardiovascular Prevention and Outcomes, University College London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Descamps, Olivier S" sort="Descamps, Olivier S" uniqKey="Descamps O" first="Olivier S" last="Descamps">Olivier S. Descamps</name>
<affiliation wicri:level="1"><nlm:affiliation>Lipid Clinic, Hopital de Jolimont, Haine-Saint-Paul, Belgium. Electronic address: olivierdescamps@hotmail.com.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Lipid Clinic, Hopital de Jolimont, Haine-Saint-Paul</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kovanen, Petri T" sort="Kovanen, Petri T" uniqKey="Kovanen P" first="Petri T" last="Kovanen">Petri T. Kovanen</name>
<affiliation wicri:level="1"><nlm:affiliation>Wihuri Research Institute, Helsinki, Finland. Electronic address: Petri.Kovanen@wri.fi.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Wihuri Research Institute, Helsinki</wicri:regionArea>
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</author>
<author><name sortKey="Riccardi, Gabriele" sort="Riccardi, Gabriele" uniqKey="Riccardi G" first="Gabriele" last="Riccardi">Gabriele Riccardi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy. Electronic address: riccardi@unina.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Clinical and Experimental Medicine, Federico II University, Naples</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tokgozoglu, Lale" sort="Tokgozoglu, Lale" uniqKey="Tokgozoglu L" first="Lale" last="Tokgözoglu">Lale Tokgözoglu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Hacettepe University, Ankara, Turkey. Electronic address: lalet@hacettepe.edu.tr.</nlm:affiliation>
<country xml:lang="fr">Turquie</country>
<wicri:regionArea>Department of Cardiology, Hacettepe University, Ankara</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chapman, M John" sort="Chapman, M John" uniqKey="Chapman M" first="M John" last="Chapman">M John Chapman</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Pierre and Marie Curie, Paris, France; Dyslipidaemia and Atherosclerosis Research Unit, INSERM U939, Pitié-Salpetriere University Hospital, Paris, France. Electronic address: john.chapman@upmc.fr.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>University of Pierre and Marie Curie, Paris, France; Dyslipidaemia and Atherosclerosis Research Unit, INSERM U939, Pitié-Salpetriere University Hospital, Paris</wicri:regionArea>
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<series><title level="j">Atherosclerosis</title>
<idno type="eISSN">1879-1484</idno>
<imprint><date when="2014" type="published">2014</date>
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<term>Anticholesteremic Agents (therapeutic use)</term>
<term>Cardiovascular Diseases (blood)</term>
<term>Cardiovascular Diseases (prevention & control)</term>
<term>Cardiovascular Diseases (therapy)</term>
<term>Cholesterol (blood)</term>
<term>Cholesterol (metabolism)</term>
<term>Cholesterol, LDL (blood)</term>
<term>Dyslipidemias (therapy)</term>
<term>Humans</term>
<term>Inflammation (drug therapy)</term>
<term>Lipids (blood)</term>
<term>Phytosterols (therapeutic use)</term>
<term>Sitosterols (therapeutic use)</term>
<term>Triglycerides (blood)</term>
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<term>Anticholestérolémiants (usage thérapeutique)</term>
<term>Cholestérol (métabolisme)</term>
<term>Cholestérol (sang)</term>
<term>Cholestérol LDL (sang)</term>
<term>Dyslipidémies ()</term>
<term>Humains</term>
<term>Inflammation (traitement médicamenteux)</term>
<term>Lipides (sang)</term>
<term>Maladies cardiovasculaires ()</term>
<term>Maladies cardiovasculaires (sang)</term>
<term>Phytostérols (usage thérapeutique)</term>
<term>Sitostérol (usage thérapeutique)</term>
<term>Triglycéride (sang)</term>
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<term>Sitosterols</term>
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<term>Dyslipidemias</term>
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<term>Humans</term>
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<front><div type="abstract" xml:lang="en">This EAS Consensus Panel critically appraised evidence relevant to the benefit to risk relationship of functional foods with added plant sterols and/or plant stanols, as components of a healthy lifestyle, to reduce plasma low-density lipoprotein-cholesterol (LDL-C) levels, and thereby lower cardiovascular risk.</div>
</front>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24468148</PMID>
<DateCreated><Year>2014</Year>
<Month>01</Month>
<Day>28</Day>
</DateCreated>
<DateCompleted><Year>2014</Year>
<Month>09</Month>
<Day>29</Day>
</DateCompleted>
<DateRevised><Year>2014</Year>
<Month>01</Month>
<Day>28</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-1484</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>232</Volume>
<Issue>2</Issue>
<PubDate><Year>2014</Year>
<Month>Feb</Month>
</PubDate>
</JournalIssue>
<Title>Atherosclerosis</Title>
<ISOAbbreviation>Atherosclerosis</ISOAbbreviation>
</Journal>
<ArticleTitle>Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease.</ArticleTitle>
<Pagination><MedlinePgn>346-60</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.atherosclerosis.2013.11.043</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S0021-9150(13)00694-1</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">This EAS Consensus Panel critically appraised evidence relevant to the benefit to risk relationship of functional foods with added plant sterols and/or plant stanols, as components of a healthy lifestyle, to reduce plasma low-density lipoprotein-cholesterol (LDL-C) levels, and thereby lower cardiovascular risk.</AbstractText>
<AbstractText Label="METHODS AND RESULTS" NlmCategory="RESULTS">Plant sterols/stanols (when taken at 2 g/day) cause significant inhibition of cholesterol absorption and lower LDL-C levels by between 8 and 10%. The relative proportions of cholesterol versus sterol/stanol levels are similar in both plasma and tissue, with levels of sterols/stanols being 500-/10,000-fold lower than those of cholesterol, suggesting they are handled similarly to cholesterol in most cells. Despite possible atherogenicity of marked elevations in circulating levels of plant sterols/stanols, protective effects have been observed in some animal models of atherosclerosis. Higher plasma levels of plant sterols/stanols associated with intakes of 2 g/day in man have not been linked to adverse effects on health in long-term human studies. Importantly, at this dose, plant sterol/stanol-mediated LDL-C lowering is additive to that of statins in dyslipidaemic subjects, equivalent to doubling the dose of statin. The reported 6-9% lowering of plasma triglyceride by 2 g/day in hypertriglyceridaemic patients warrants further evaluation.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Based on LDL-C lowering and the absence of adverse signals, this EAS Consensus Panel concludes that functional foods with plant sterols/stanols may be considered 1) in individuals with high cholesterol levels at intermediate or low global cardiovascular risk who do not qualify for pharmacotherapy, 2) as an adjunct to pharmacologic therapy in high and very high risk patients who fail to achieve LDL-C targets on statins or are statin- intolerant, 3) and in adults and children (>6 years) with familial hypercholesterolaemia, in line with current guidance. However, it must be acknowledged that there are no randomised, controlled clinical trial data with hard end-points to establish clinical benefit from the use of plant sterols or plant stanols.</AbstractText>
<CopyrightInformation>Copyright © 2013 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gylling</LastName>
<ForeName>Helena</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Division of Internal Medicine, University of Helsinki, Biomedicum Helsinki, Finland. Electronic address: Helena.Gylling@hus.fi.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Plat</LastName>
<ForeName>Jogchum</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Human Biology, Maastricht University, The Netherlands. Electronic address: j.plat@maastrichtuniversity.nl.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Turley</LastName>
<ForeName>Stephen</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Internal Medicine, UT Southwestern Medical Center, Dallas, USA. Electronic address: Stephen.Turley@UTSouthwestern.edu.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ginsberg</LastName>
<ForeName>Henry N</ForeName>
<Initials>HN</Initials>
<AffiliationInfo><Affiliation>Irving Institute for Clinical and Translational Research, Columbia University, New York, USA. Electronic address: hng1@columbia.edu.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ellegård</LastName>
<ForeName>Lars</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy at University of Gothenburg, Sweden. Electronic address: lasse.ellegard@nutrition.gu.se.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jessup</LastName>
<ForeName>Wendy</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>ANZAC Research Institute, Concord Hospital, Sydney, Australia. Electronic address: wendy.jessup@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jones</LastName>
<ForeName>Peter J</ForeName>
<Initials>PJ</Initials>
<AffiliationInfo><Affiliation>Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Canada. Electronic address: Peter.Jones@umanitoba.ca.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lütjohann</LastName>
<ForeName>Dieter</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Institute of Clinical Chemistry and Clinical Pharmacology, University Clinics Bonn, Germany. Electronic address: Dieter.Luetjohann@ukb.uni-bonn.de.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Maerz</LastName>
<ForeName>Winfried</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Synlab Academy, Synlab LLC, Mannheim Center of Laboratory Diagnostics, Heidelberg, Germany; Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty Mannheim, University of Heidelberg, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria. Electronic address: Winfried.Maerz@synlab.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Masana</LastName>
<ForeName>Luis</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Vascular Medicine and Metabolism Unit, University Hospital Sant Joan, IISPV, CIBERDEM, Rovira and Virgili University, Reus, Spain. Electronic address: luis.masana@urv.cat.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Silbernagel</LastName>
<ForeName>Günther</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Angiology, Swiss Cardiovascular Center, Inselspital, University of Bern, Switzerland. Electronic address: guenther.silbernagel@yahoo.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Staels</LastName>
<ForeName>Bart</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Faculty of Pharmacy, University of Lille 2, Lille, France. Electronic address: Bart.Staels@pasteur-lille.fr.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Borén</LastName>
<ForeName>Jan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Strategic Research Center, Sahlgrenska Center for Cardiovascular and Metabolic Research (CMR), University of Gothenburg, Sweden. Electronic address: Jan.Boren@wlab.gu.se.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Catapano</LastName>
<ForeName>Alberico L</ForeName>
<Initials>AL</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacological and Biomolecular Sciences, University of Milan, Italy; Multimedica IRCSS Milano, Italy. Electronic address: alberico.catapano@unimi.it.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>De Backer</LastName>
<ForeName>Guy</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Public Health, University Hospital Ghent, Ghent, Belgium. Electronic address: guy.debacker@ugent.be.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Deanfield</LastName>
<ForeName>John</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>National Centre for Cardiovascular Prevention and Outcomes, University College London, UK. Electronic address: john.deanfield@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Descamps</LastName>
<ForeName>Olivier S</ForeName>
<Initials>OS</Initials>
<AffiliationInfo><Affiliation>Lipid Clinic, Hopital de Jolimont, Haine-Saint-Paul, Belgium. Electronic address: olivierdescamps@hotmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kovanen</LastName>
<ForeName>Petri T</ForeName>
<Initials>PT</Initials>
<AffiliationInfo><Affiliation>Wihuri Research Institute, Helsinki, Finland. Electronic address: Petri.Kovanen@wri.fi.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Riccardi</LastName>
<ForeName>Gabriele</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy. Electronic address: riccardi@unina.it.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tokgözoglu</LastName>
<ForeName>Lale</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Cardiology, Hacettepe University, Ankara, Turkey. Electronic address: lalet@hacettepe.edu.tr.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chapman</LastName>
<ForeName>M John</ForeName>
<Initials>MJ</Initials>
<AffiliationInfo><Affiliation>University of Pierre and Marie Curie, Paris, France; Dyslipidaemia and Atherosclerosis Research Unit, INSERM U939, Pitié-Salpetriere University Hospital, Paris, France. Electronic address: john.chapman@upmc.fr.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>European Atherosclerosis Society Consensus Panel on Phytosterols</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>R01HL09610</GrantID>
<Acronym>HL</Acronym>
<Agency>NHLBI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
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<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
<PublicationType UI="D016454">Review</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2013</Year>
<Month>11</Month>
<Day>23</Day>
</ArticleDate>
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<MedlineJournalInfo><Country>Ireland</Country>
<MedlineTA>Atherosclerosis</MedlineTA>
<NlmUniqueID>0242543</NlmUniqueID>
<ISSNLinking>0021-9150</ISSNLinking>
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<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Atherosclerosis. 2014 Apr;233(2):357-8</RefSource>
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<Keyword MajorTopicYN="N">Hypercholesterolaemia</Keyword>
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	Serveur d'exploration sur les relations entre la France et l'Australie
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Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease.

Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease.

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