KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference.
Identifieur interne : 001473 ( PubMed/Curation ); précédent : 001472; suivant : 001474KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference.
Auteurs : Gunter Schumann [Royaume-Uni] ; Chunyu Liu [États-Unis] ; Paul O'Reilly [Royaume-Uni] ; He Gao [Royaume-Uni] ; Parkyong Song [États-Unis] ; Bing Xu [Royaume-Uni] ; Barbara Ruggeri [Royaume-Uni] ; Najaf Amin [Pays-Bas] ; Tianye Jia [Royaume-Uni] ; Sarah Preis [États-Unis] ; Marcelo Segura Lepe [Royaume-Uni] ; Shizuo Akira [Japon] ; Caterina Barbieri [Italie] ; Sebastian Baumeister [Allemagne] ; Stephane Cauchi [France] ; Toni-Kim Clarke [Royaume-Uni] ; Stefan Enroth [Suède] ; Krista Fischer [Estonie] ; Jenni H Llfors [Finlande] ; Sarah E. Harris [Royaume-Uni] ; Saskia Hieber [Allemagne] ; Edith Hofer [Autriche] ; Jouke-Jan Hottenga [Pays-Bas] ; Sa Johansson [Suède] ; Peter K. Joshi [Royaume-Uni] ; Niina Kaartinen [Finlande] ; Jaana Laitinen [Finlande] ; Rozenn Lemaitre [États-Unis] ; Anu Loukola [Finlande] ; Jian'An Luan [Royaume-Uni] ; Leo-Pekka Lyytik Inen [Finlande] ; Massimo Mangino [Royaume-Uni] ; Ani Manichaikul [États-Unis] ; Hamdi Mbarek [Pays-Bas] ; Yuri Milaneschi [Pays-Bas] ; Alireza Moayyeri [Royaume-Uni] ; Kenneth Mukamal [États-Unis] ; Christopher Nelson [Royaume-Uni] ; Jennifer Nettleton [États-Unis] ; Eemil Partinen [Estonie] ; Rajesh Rawal [Allemagne] ; Antonietta Robino [Italie] ; Lynda Rose [États-Unis] ; Cinzia Sala [Italie] ; Takashi Satoh [Japon] ; Reinhold Schmidt [Autriche] ; Katharina Schraut [Royaume-Uni] ; Robert Scott [Royaume-Uni] ; Albert Vernon Smith [Islande] ; John M. Starr [Royaume-Uni] ; Alexander Teumer [Allemagne] ; Stella Trompet [Pays-Bas] ; André G. Uitterlinden [Pays-Bas] ; Cristina Venturini [Royaume-Uni] ; Anne-Claire Vergnaud [Royaume-Uni] ; Niek Verweij [Pays-Bas] ; Veronique Vitart [Royaume-Uni] ; Dragana Vuckovic [Italie] ; Juho Wedenoja [Finlande] ; Loic Yengo [France] ; Bing Yu [États-Unis] ; Weihua Zhang [Royaume-Uni] ; Jing Hua Zhao [Royaume-Uni] ; Dorret I. Boomsma [Pays-Bas] ; John Chambers [Royaume-Uni] ; Daniel I. Chasman [États-Unis] ; Toniolo Daniela [Italie] ; Eco De Geus [Pays-Bas] ; Ian Deary [Royaume-Uni] ; Johan G. Eriksson [Finlande] ; T Nu Esko [Estonie] ; Volker Eulenburg [Allemagne] ; Oscar H. Franco [Pays-Bas] ; Philippe Froguel [France] ; Christian Gieger [Allemagne] ; Hans J. Grabe [Allemagne] ; Vilmundur Gudnason [Islande] ; Ulf Gyllensten [Suède] ; Tamara B. Harris [États-Unis] ; Anna-Liisa Hartikainen [Finlande] ; Andrew C. Heath [États-Unis] ; Lynne Hocking [Royaume-Uni] ; Albert Hofman [Pays-Bas] ; Cornelia Huth [Allemagne] ; Marjo-Riitta Jarvelin [Royaume-Uni] ; J Wouter Jukema [Pays-Bas] ; Jaakko Kaprio [Finlande] ; Jaspal S. Kooner [Royaume-Uni] ; Zoltan Kutalik [Suisse] ; Jari Lahti [Finlande] ; Claudia Langenberg [Royaume-Uni] ; Terho Lehtim Ki [Finlande] ; Yongmei Liu [États-Unis] ; Pamela A F. Madden [États-Unis] ; Nicholas Martin [Australie] ; Alanna Morrison [États-Unis] ; Brenda Penninx [Pays-Bas] ; Nicola Pirastu [Royaume-Uni] ; Bruce Psaty [États-Unis] ; Olli Raitakari [Finlande] ; Paul Ridker [États-Unis] ; Richard Rose [États-Unis] ; Jerome I. Rotter [États-Unis] ; Nilesh J. Samani [Royaume-Uni] ; Helena Schmidt [Autriche] ; Tim D. Spector [Royaume-Uni] ; David Stott [Royaume-Uni] ; David Strachan [Royaume-Uni] ; Ioanna Tzoulaki [Royaume-Uni] ; Pim Van Der Harst [Pays-Bas] ; Cornelia M. Van Duijn [Pays-Bas] ; Pedro Marques-Vidal [Suisse] ; Peter Vollenweider [Suisse] ; Nicholas J. Wareham [Royaume-Uni] ; John B. Whitfield [Australie] ; James Wilson [Royaume-Uni] ; Bruce Wolffenbuttel [Pays-Bas] ; Georgy Bakalkin [Suède] ; Evangelos Evangelou [Royaume-Uni] ; Yun Liu [République populaire de Chine] ; Kenneth M. Rice [États-Unis] ; Sylvane Desrivières [Royaume-Uni] ; Steven A. Kliewer [États-Unis] ; David J. Mangelsdorf [Royaume-Uni] ; Christian P. Müller [Allemagne] ; Daniel Levy [États-Unis] ; Paul Elliott [Royaume-Uni]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 1091-6490 ] ; 2016.
Abstract
Excessive alcohol consumption is a major public health problem worldwide. Although drinking habits are known to be inherited, few genes have been identified that are robustly linked to alcohol drinking. We conducted a genome-wide association metaanalysis and replication study among >105,000 individuals of European ancestry and identified β-Klotho (KLB) as a locus associated with alcohol consumption (rs11940694; P = 9.2 × 10(-12)). β-Klotho is an obligate coreceptor for the hormone FGF21, which is secreted from the liver and implicated in macronutrient preference in humans. We show that brain-specific β-Klotho KO mice have an increased alcohol preference and that FGF21 inhibits alcohol drinking by acting on the brain. These data suggest that a liver-brain endocrine axis may play an important role in the regulation of alcohol drinking behavior and provide a unique pharmacologic target for reducing alcohol consumption.
DOI: 10.1073/pnas.1611243113
PubMed: 27911795
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001495
Links to Exploration step
pubmed:27911795Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference.</title><author><name sortKey="Schumann, Gunter" sort="Schumann, Gunter" uniqKey="Schumann G" first="Gunter" last="Schumann">Gunter Schumann</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom; gunter.schumann@kcl.ac.uk davo.mango@utsouthwestern.edu p.elliott@imperial.ac.uk.</nlm:affiliation><country wicri:rule="url">Royaume-Uni</country><wicri:regionArea>Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Chunyu" sort="Liu, Chunyu" uniqKey="Liu C" first="Chunyu" last="Liu">Chunyu Liu</name><affiliation wicri:level="2"><nlm:affiliation>The Framingham Heart Study, Framingham, MA 01702.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>The Framingham Heart Study, Framingham</wicri:cityArea></affiliation></author><author><name sortKey="O Reilly, Paul" sort="O Reilly, Paul" uniqKey="O Reilly P" first="Paul" last="O'Reilly">Paul O'Reilly</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF</wicri:regionArea></affiliation></author><author><name sortKey="Gao, He" sort="Gao, He" uniqKey="Gao H" first="He" last="Gao">He Gao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG</wicri:regionArea></affiliation></author><author><name sortKey="Song, Parkyong" sort="Song, Parkyong" uniqKey="Song P" first="Parkyong" last="Song">Parkyong Song</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas</wicri:cityArea></affiliation></author><author><name sortKey="Xu, Bing" sort="Xu, Bing" uniqKey="Xu B" first="Bing" last="Xu">Bing Xu</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF</wicri:regionArea></affiliation></author><author><name sortKey="Ruggeri, Barbara" sort="Ruggeri, Barbara" uniqKey="Ruggeri B" first="Barbara" last="Ruggeri">Barbara Ruggeri</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF</wicri:regionArea></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Jia, Tianye" sort="Jia, Tianye" uniqKey="Jia T" first="Tianye" last="Jia">Tianye Jia</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF</wicri:regionArea></affiliation></author><author><name sortKey="Preis, Sarah" sort="Preis, Sarah" uniqKey="Preis S" first="Sarah" last="Preis">Sarah Preis</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Biostatistics, Boston University School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Segura Lepe, Marcelo" sort="Segura Lepe, Marcelo" uniqKey="Segura Lepe M" first="Marcelo" last="Segura Lepe">Marcelo Segura Lepe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG</wicri:regionArea></affiliation></author><author><name sortKey="Akira, Shizuo" sort="Akira, Shizuo" uniqKey="Akira S" first="Shizuo" last="Akira">Shizuo Akira</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871</wicri:regionArea></affiliation></author><author><name sortKey="Barbieri, Caterina" sort="Barbieri, Caterina" uniqKey="Barbieri C" first="Caterina" last="Barbieri">Caterina Barbieri</name><affiliation wicri:level="1"><nlm:affiliation>Division of Genetics and Cell Biology, San Raffaele Research Institute, 20132 Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Genetics and Cell Biology, San Raffaele Research Institute, 20132 Milan</wicri:regionArea></affiliation></author><author><name sortKey="Baumeister, Sebastian" sort="Baumeister, Sebastian" uniqKey="Baumeister S" first="Sebastian" last="Baumeister">Sebastian Baumeister</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald 17475, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Community Medicine, University Medicine Greifswald, Greifswald 17475</wicri:regionArea></affiliation></author><author><name sortKey="Cauchi, Stephane" sort="Cauchi, Stephane" uniqKey="Cauchi S" first="Stephane" last="Cauchi">Stephane Cauchi</name><affiliation wicri:level="1"><nlm:affiliation>CNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes, Lille 2 University, 59000 Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes, Lille 2 University, 59000 Lille</wicri:regionArea></affiliation></author><author><name sortKey="Clarke, Toni Kim" sort="Clarke, Toni Kim" uniqKey="Clarke T" first="Toni-Kim" last="Clarke">Toni-Kim Clarke</name><affiliation wicri:level="1"><nlm:affiliation>Divison of Psychiatry, University of Edinburgh, Edinburgh EH10 5HF, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Divison of Psychiatry, University of Edinburgh, Edinburgh EH10 5HF</wicri:regionArea></affiliation></author><author><name sortKey="Enroth, Stefan" sort="Enroth, Stefan" uniqKey="Enroth S" first="Stefan" last="Enroth">Stefan Enroth</name><affiliation wicri:level="1"><nlm:affiliation>Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 75108 Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 75108 Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Fischer, Krista" sort="Fischer, Krista" uniqKey="Fischer K" first="Krista" last="Fischer">Krista Fischer</name><affiliation wicri:level="1"><nlm:affiliation>Estonian Genome Center, University of Tartu, 51010 Tartu, Estonia.</nlm:affiliation><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center, University of Tartu, 51010 Tartu</wicri:regionArea></affiliation></author><author><name sortKey="H Llfors, Jenni" sort="H Llfors, Jenni" uniqKey="H Llfors J" first="Jenni" last="H Llfors">Jenni H Llfors</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Molecular Medicine, University of Helsinki, 00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine, University of Helsinki, 00290 Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Harris, Sarah E" sort="Harris, Sarah E" uniqKey="Harris S" first="Sarah E" last="Harris">Sarah E. Harris</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ</wicri:regionArea></affiliation></author><author><name sortKey="Hieber, Saskia" sort="Hieber, Saskia" uniqKey="Hieber S" first="Saskia" last="Hieber">Saskia Hieber</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Friedrich Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Friedrich Alexander University Erlangen-Nuremberg, 91054 Erlangen</wicri:regionArea></affiliation></author><author><name sortKey="Hofer, Edith" sort="Hofer, Edith" uniqKey="Hofer E" first="Edith" last="Hofer">Edith Hofer</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, 8036 Graz, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, 8036 Graz</wicri:regionArea></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Psychology, Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research, 1081 BT Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research, 1081 BT Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><affiliation wicri:level="1"><nlm:affiliation>Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 75108 Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 75108 Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Joshi, Peter K" sort="Joshi, Peter K" uniqKey="Joshi P" first="Peter K" last="Joshi">Peter K. Joshi</name><affiliation wicri:level="1"><nlm:affiliation>Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG</wicri:regionArea></affiliation></author><author><name sortKey="Kaartinen, Niina" sort="Kaartinen, Niina" uniqKey="Kaartinen N" first="Niina" last="Kaartinen">Niina Kaartinen</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health and Welfare, 00271 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare, 00271 Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Laitinen, Jaana" sort="Laitinen, Jaana" uniqKey="Laitinen J" first="Jaana" last="Laitinen">Jaana Laitinen</name><affiliation wicri:level="1"><nlm:affiliation>Quantified Employee-Unit, Finnish Institute of Occupational Health, 00250 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Quantified Employee-Unit, Finnish Institute of Occupational Health, 00250 Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Lemaitre, Rozenn" sort="Lemaitre, Rozenn" uniqKey="Lemaitre R" first="Rozenn" last="Lemaitre">Rozenn Lemaitre</name><affiliation wicri:level="2"><nlm:affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Loukola, Anu" sort="Loukola, Anu" uniqKey="Loukola A" first="Anu" last="Loukola">Anu Loukola</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Molecular Medicine, University of Helsinki, 00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine, University of Helsinki, 00290 Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Luan, Jian An" sort="Luan, Jian An" uniqKey="Luan J" first="Jian'An" last="Luan">Jian'An Luan</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ</wicri:regionArea></affiliation></author><author><name sortKey="Lyytik Inen, Leo Pekka" sort="Lyytik Inen, Leo Pekka" uniqKey="Lyytik Inen L" first="Leo-Pekka" last="Lyytik Inen">Leo-Pekka Lyytik Inen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere 33520, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere 33520</wicri:regionArea></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation wicri:level="1"><nlm:affiliation>Department of Twin Research and Genetic Epidemiology, King's College, London SE1 7EH, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College, London SE1 7EH</wicri:regionArea></affiliation></author><author><name sortKey="Manichaikul, Ani" sort="Manichaikul, Ani" uniqKey="Manichaikul A" first="Ani" last="Manichaikul">Ani Manichaikul</name><affiliation wicri:level="2"><nlm:affiliation>Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22903.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville</wicri:cityArea></affiliation></author><author><name sortKey="Mbarek, Hamdi" sort="Mbarek, Hamdi" uniqKey="Mbarek H" first="Hamdi" last="Mbarek">Hamdi Mbarek</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Psychology, Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research, 1081 BT Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research, 1081 BT Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Milaneschi, Yuri" sort="Milaneschi, Yuri" uniqKey="Milaneschi Y" first="Yuri" last="Milaneschi">Yuri Milaneschi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Institute for Health and Care Research (EMGO) Institute for Health and Care Research and Neuroscience Campus Amsterdam, Vrije Universiteit Amsterdam University Medical Center/Geestelijke Gezondheids Zorg (GGZ) inGeest, 1081 HL Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Institute for Health and Care Research (EMGO) Institute for Health and Care Research and Neuroscience Campus Amsterdam, Vrije Universiteit Amsterdam University Medical Center/Geestelijke Gezondheids Zorg (GGZ) inGeest, 1081 HL Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Moayyeri, Alireza" sort="Moayyeri, Alireza" uniqKey="Moayyeri A" first="Alireza" last="Moayyeri">Alireza Moayyeri</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG</wicri:regionArea></affiliation></author><author><name sortKey="Mukamal, Kenneth" sort="Mukamal, Kenneth" uniqKey="Mukamal K" first="Kenneth" last="Mukamal">Kenneth Mukamal</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Nelson, Christopher" sort="Nelson, Christopher" uniqKey="Nelson C" first="Christopher" last="Nelson">Christopher Nelson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP</wicri:regionArea></affiliation></author><author><name sortKey="Nettleton, Jennifer" sort="Nettleton, Jennifer" uniqKey="Nettleton J" first="Jennifer" last="Nettleton">Jennifer Nettleton</name><affiliation wicri:level="2"><nlm:affiliation>Division of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Sciences Center, Houston, TX 77225.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Division of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Sciences Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Partinen, Eemil" sort="Partinen, Eemil" uniqKey="Partinen E" first="Eemil" last="Partinen">Eemil Partinen</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, University of Tartu, 50411 Tartu, Estonia.</nlm:affiliation><country xml:lang="fr">Estonie</country><wicri:regionArea>Faculty of Medicine, University of Tartu, 50411 Tartu</wicri:regionArea></affiliation></author><author><name sortKey="Rawal, Rajesh" sort="Rawal, Rajesh" uniqKey="Rawal R" first="Rajesh" last="Rawal">Rajesh Rawal</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Robino, Antonietta" sort="Robino, Antonietta" uniqKey="Robino A" first="Antonietta" last="Robino">Antonietta Robino</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Maternal and Child Health-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Burlo Garofolo, 34137 Trieste, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute for Maternal and Child Health-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Burlo Garofolo, 34137 Trieste</wicri:regionArea></affiliation></author><author><name sortKey="Rose, Lynda" sort="Rose, Lynda" uniqKey="Rose L" first="Lynda" last="Rose">Lynda Rose</name><affiliation wicri:level="2"><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Preventive Medicine, Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Sala, Cinzia" sort="Sala, Cinzia" uniqKey="Sala C" first="Cinzia" last="Sala">Cinzia Sala</name><affiliation wicri:level="1"><nlm:affiliation>Division of Genetics and Cell Biology, San Raffaele Research Institute, 20132 Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Genetics and Cell Biology, San Raffaele Research Institute, 20132 Milan</wicri:regionArea></affiliation></author><author><name sortKey="Satoh, Takashi" sort="Satoh, Takashi" uniqKey="Satoh T" first="Takashi" last="Satoh">Takashi Satoh</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, 8036 Graz, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, 8036 Graz</wicri:regionArea></affiliation></author><author><name sortKey="Schraut, Katharina" sort="Schraut, Katharina" uniqKey="Schraut K" first="Katharina" last="Schraut">Katharina Schraut</name><affiliation wicri:level="1"><nlm:affiliation>Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG</wicri:regionArea></affiliation></author><author><name sortKey="Scott, Robert" sort="Scott, Robert" uniqKey="Scott R" first="Robert" last="Scott">Robert Scott</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name><affiliation wicri:level="1"><nlm:affiliation>Research Institute, Icelandic Heart Association, 201 Kopavogur, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>Research Institute, Icelandic Heart Association, 201 Kopavogur</wicri:regionArea></affiliation></author><author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M" last="Starr">John M. Starr</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ</wicri:regionArea></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald 17475, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Community Medicine, University Medicine Greifswald, Greifswald 17475</wicri:regionArea></affiliation></author><author><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G" last="Uitterlinden">André G. Uitterlinden</name><affiliation wicri:level="1"><nlm:affiliation>Department of internal Medicine, Erasmus Medical Center, 3015 CN Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of internal Medicine, Erasmus Medical Center, 3015 CN Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Venturini, Cristina" sort="Venturini, Cristina" uniqKey="Venturini C" first="Cristina" last="Venturini">Cristina Venturini</name><affiliation wicri:level="1"><nlm:affiliation>Department of Twin Research and Genetic Epidemiology, King's College, London SE1 7EH, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College, London SE1 7EH</wicri:regionArea></affiliation></author><author><name sortKey="Vergnaud, Anne Claire" sort="Vergnaud, Anne Claire" uniqKey="Vergnaud A" first="Anne-Claire" last="Vergnaud">Anne-Claire Vergnaud</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG</wicri:regionArea></affiliation></author><author><name sortKey="Verweij, Niek" sort="Verweij, Niek" uniqKey="Verweij N" first="Niek" last="Verweij">Niek Verweij</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU</wicri:regionArea></affiliation></author><author><name sortKey="Vuckovic, Dragana" sort="Vuckovic, Dragana" uniqKey="Vuckovic D" first="Dragana" last="Vuckovic">Dragana Vuckovic</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Sciences, University of Trieste, 34149 Trieste, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Sciences, University of Trieste, 34149 Trieste</wicri:regionArea></affiliation></author><author><name sortKey="Wedenoja, Juho" sort="Wedenoja, Juho" uniqKey="Wedenoja J" first="Juho" last="Wedenoja">Juho Wedenoja</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health, University of Helsinki, 00014 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Public Health, University of Helsinki, 00014 Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Yengo, Loic" sort="Yengo, Loic" uniqKey="Yengo L" first="Loic" last="Yengo">Loic Yengo</name><affiliation wicri:level="1"><nlm:affiliation>CNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes, Lille 2 University, 59000 Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes, Lille 2 University, 59000 Lille</wicri:regionArea></affiliation></author><author><name sortKey="Yu, Bing" sort="Yu, Bing" uniqKey="Yu B" first="Bing" last="Yu">Bing Yu</name><affiliation wicri:level="2"><nlm:affiliation>Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77225.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Human Genetics Center, University of Texas Health Science Center at Houston, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Zhang, Weihua" sort="Zhang, Weihua" uniqKey="Zhang W" first="Weihua" last="Zhang">Weihua Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ</wicri:regionArea></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I" last="Boomsma">Dorret I. Boomsma</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Psychology, Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research, 1081 BT Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research, 1081 BT Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Chambers, John" sort="Chambers, John" uniqKey="Chambers J" first="John" last="Chambers">John Chambers</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG</wicri:regionArea></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I" last="Chasman">Daniel I. Chasman</name><affiliation wicri:level="2"><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Preventive Medicine, Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Daniela, Toniolo" sort="Daniela, Toniolo" uniqKey="Daniela T" first="Toniolo" last="Daniela">Toniolo Daniela</name><affiliation wicri:level="1"><nlm:affiliation>Division of Genetics and Cell Biology, San Raffaele Research Institute, 20132 Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Genetics and Cell Biology, San Raffaele Research Institute, 20132 Milan</wicri:regionArea></affiliation></author><author><name sortKey="De Geus, Eco" sort="De Geus, Eco" uniqKey="De Geus E" first="Eco" last="De Geus">Eco De Geus</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Psychology, Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research, 1081 BT Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research, 1081 BT Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Deary, Ian" sort="Deary, Ian" uniqKey="Deary I" first="Ian" last="Deary">Ian Deary</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ</wicri:regionArea></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G" last="Eriksson">Johan G. Eriksson</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health and Welfare, 00271 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare, 00271 Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation wicri:level="1"><nlm:affiliation>Estonian Genome Center, University of Tartu, 51010 Tartu, Estonia.</nlm:affiliation><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center, University of Tartu, 51010 Tartu</wicri:regionArea></affiliation></author><author><name sortKey="Eulenburg, Volker" sort="Eulenburg, Volker" uniqKey="Eulenburg V" first="Volker" last="Eulenburg">Volker Eulenburg</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Biochemistry and Molecular Medicine, Friedrich Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Biochemistry and Molecular Medicine, Friedrich Alexander University Erlangen-Nuremberg, 91054 Erlangen</wicri:regionArea></affiliation></author><author><name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H" last="Franco">Oscar H. Franco</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation wicri:level="1"><nlm:affiliation>CNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes, Lille 2 University, 59000 Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes, Lille 2 University, 59000 Lille</wicri:regionArea></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Grabe, Hans J" sort="Grabe, Hans J" uniqKey="Grabe H" first="Hans J" last="Grabe">Hans J. Grabe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475 Greifswald, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475 Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation wicri:level="1"><nlm:affiliation>Research Institute, Icelandic Heart Association, 201 Kopavogur, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>Research Institute, Icelandic Heart Association, 201 Kopavogur</wicri:regionArea></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation wicri:level="1"><nlm:affiliation>Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 75108 Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 75108 Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B" last="Harris">Tamara B. Harris</name><affiliation wicri:level="2"><nlm:affiliation>National Institute on Aging, NIH, Bethesda, MD 20892.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>National Institute on Aging, NIH, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Obstetrics and Gynecology, Oulu University Hospital, 90029 Oulu, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Obstetrics and Gynecology, Oulu University Hospital, 90029 Oulu</wicri:regionArea></affiliation></author><author><name sortKey="Heath, Andrew C" sort="Heath, Andrew C" uniqKey="Heath A" first="Andrew C" last="Heath">Andrew C. Heath</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO 63110.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Department of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis</wicri:cityArea></affiliation></author><author><name sortKey="Hocking, Lynne" sort="Hocking, Lynne" uniqKey="Hocking L" first="Lynne" last="Hocking">Lynne Hocking</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD</wicri:regionArea></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Huth, Cornelia" sort="Huth, Cornelia" uniqKey="Huth C" first="Cornelia" last="Huth">Cornelia Huth</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, D-85764 Neuherberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, D-85764 Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG</wicri:regionArea></affiliation></author><author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J Wouter" last="Jukema">J Wouter Jukema</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Molecular Medicine, University of Helsinki, 00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine, University of Helsinki, 00290 Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S" last="Kooner">Jaspal S. Kooner</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW</wicri:regionArea></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltan" last="Kutalik">Zoltan Kutalik</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudoise, 1010 Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudoise, 1010 Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name><affiliation wicri:level="1"><nlm:affiliation>Folkhälsan Research Centre, Public Health Research, 00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Folkhälsan Research Centre, Public Health Research, 00290 Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ</wicri:regionArea></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere 33520, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere 33520</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name><affiliation wicri:level="2"><nlm:affiliation>Wake Forest School of Medicine, Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Wake Forest School of Medicine, Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem</wicri:cityArea></affiliation></author><author><name sortKey="Madden, Pamela A F" sort="Madden, Pamela A F" uniqKey="Madden P" first="Pamela A F" last="Madden">Pamela A F. Madden</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Department of Psychiatry, Washington University School of Medicine, St. Louis</wicri:cityArea></affiliation></author><author><name sortKey="Martin, Nicholas" sort="Martin, Nicholas" uniqKey="Martin N" first="Nicholas" last="Martin">Nicholas Martin</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology, Queensland Institute of Medical Research Berghofer Medical Research Institute, Herston, Brisbane QLD 4029, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology, Queensland Institute of Medical Research Berghofer Medical Research Institute, Herston, Brisbane QLD 4029</wicri:regionArea></affiliation></author><author><name sortKey="Morrison, Alanna" sort="Morrison, Alanna" uniqKey="Morrison A" first="Alanna" last="Morrison">Alanna Morrison</name><affiliation wicri:level="2"><nlm:affiliation>Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77225.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Human Genetics Center, University of Texas Health Science Center at Houston, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Penninx, Brenda" sort="Penninx, Brenda" uniqKey="Penninx B" first="Brenda" last="Penninx">Brenda Penninx</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Institute for Health and Care Research (EMGO) Institute for Health and Care Research and Neuroscience Campus Amsterdam, Vrije Universiteit Amsterdam University Medical Center/Geestelijke Gezondheids Zorg (GGZ) inGeest, 1081 HL Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Institute for Health and Care Research (EMGO) Institute for Health and Care Research and Neuroscience Campus Amsterdam, Vrije Universiteit Amsterdam University Medical Center/Geestelijke Gezondheids Zorg (GGZ) inGeest, 1081 HL Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Pirastu, Nicola" sort="Pirastu, Nicola" uniqKey="Pirastu N" first="Nicola" last="Pirastu">Nicola Pirastu</name><affiliation wicri:level="1"><nlm:affiliation>Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG</wicri:regionArea></affiliation></author><author><name sortKey="Psaty, Bruce" sort="Psaty, Bruce" uniqKey="Psaty B" first="Bruce" last="Psaty">Bruce Psaty</name><affiliation wicri:level="2"><nlm:affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, University of Turku, Turku 20520, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, University of Turku, Turku 20520</wicri:regionArea></affiliation></author><author><name sortKey="Ridker, Paul" sort="Ridker, Paul" uniqKey="Ridker P" first="Paul" last="Ridker">Paul Ridker</name><affiliation wicri:level="2"><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Preventive Medicine, Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Rose, Richard" sort="Rose, Richard" uniqKey="Rose R" first="Richard" last="Rose">Richard Rose</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Indiana</region></placeName><wicri:cityArea>Department of Psychological and Brain Sciences, Indiana University, Bloomington</wicri:cityArea></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I" last="Rotter">Jerome I. Rotter</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles Medical Center, Torrance, CA 90509.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles Medical Center, Torrance</wicri:cityArea></affiliation></author><author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J" last="Samani">Nilesh J. Samani</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, 8010 Graz, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, 8010 Graz</wicri:regionArea></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D" last="Spector">Tim D. Spector</name><affiliation wicri:level="1"><nlm:affiliation>Department of Twin Research and Genetic Epidemiology, King's College, London SE1 7EH, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College, London SE1 7EH</wicri:regionArea></affiliation></author><author><name sortKey="Stott, David" sort="Stott, David" uniqKey="Stott D" first="David" last="Stott">David Stott</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow G31 2ER, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow G31 2ER</wicri:regionArea></affiliation></author><author><name sortKey="Strachan, David" sort="Strachan, David" uniqKey="Strachan D" first="David" last="Strachan">David Strachan</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, St. George's, University of London, London SW17 0RE, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Population Health Research Institute, St. George's, University of London, London SW17 0RE</wicri:regionArea></affiliation></author><author><name sortKey="Tzoulaki, Ioanna" sort="Tzoulaki, Ioanna" uniqKey="Tzoulaki I" first="Ioanna" last="Tzoulaki">Ioanna Tzoulaki</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Marques Vidal, Pedro" sort="Marques Vidal, Pedro" uniqKey="Marques Vidal P" first="Pedro" last="Marques-Vidal">Pedro Marques-Vidal</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Internal Medicine, Lausanne University Hospital, 1011 Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Medicine, Internal Medicine, Lausanne University Hospital, 1011 Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Internal Medicine, Lausanne University Hospital, 1011 Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Medicine, Internal Medicine, Lausanne University Hospital, 1011 Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ</wicri:regionArea></affiliation></author><author><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B" last="Whitfield">John B. Whitfield</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology, Queensland Institute of Medical Research Berghofer Medical Research Institute, Herston, Brisbane QLD 4029, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology, Queensland Institute of Medical Research Berghofer Medical Research Institute, Herston, Brisbane QLD 4029</wicri:regionArea></affiliation></author><author><name sortKey="Wilson, James" sort="Wilson, James" uniqKey="Wilson J" first="James" last="Wilson">James Wilson</name><affiliation wicri:level="1"><nlm:affiliation>Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG</wicri:regionArea></affiliation></author><author><name sortKey="Wolffenbuttel, Bruce" sort="Wolffenbuttel, Bruce" uniqKey="Wolffenbuttel B" first="Bruce" last="Wolffenbuttel">Bruce Wolffenbuttel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Endocrinology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Endocrinology, University Medical Center Groningen, University of Groningen, 9700RB Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Bakalkin, Georgy" sort="Bakalkin, Georgy" uniqKey="Bakalkin G" first="Georgy" last="Bakalkin">Georgy Bakalkin</name><affiliation wicri:level="1"><nlm:affiliation>Division of Biological Research on Drug Dependence, Department of Pharmaceutical, Biosciences, Uppsala University, 751 24 Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Biological Research on Drug Dependence, Department of Pharmaceutical, Biosciences, Uppsala University, 751 24 Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Evangelou, Evangelos" sort="Evangelou, Evangelos" uniqKey="Evangelou E" first="Evangelos" last="Evangelou">Evangelos Evangelou</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Yun" sort="Liu, Yun" uniqKey="Liu Y" first="Yun" last="Liu">Yun Liu</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, 200032 Shanghai, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, 200032 Shanghai</wicri:regionArea></affiliation></author><author><name sortKey="Rice, Kenneth M" sort="Rice, Kenneth M" uniqKey="Rice K" first="Kenneth M" last="Rice">Kenneth M. Rice</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biostatistics, University of Washington, Seattle, WA 98195.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Department of Biostatistics, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Desrivieres, Sylvane" sort="Desrivieres, Sylvane" uniqKey="Desrivieres S" first="Sylvane" last="Desrivières">Sylvane Desrivières</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF</wicri:regionArea></affiliation></author><author><name sortKey="Kliewer, Steven A" sort="Kliewer, Steven A" uniqKey="Kliewer S" first="Steven A" last="Kliewer">Steven A. Kliewer</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas</wicri:cityArea></affiliation></author><author><name sortKey="Mangelsdorf, David J" sort="Mangelsdorf, David J" uniqKey="Mangelsdorf D" first="David J" last="Mangelsdorf">David J. Mangelsdorf</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390; gunter.schumann@kcl.ac.uk davo.mango@utsouthwestern.edu p.elliott@imperial.ac.uk.</nlm:affiliation><country wicri:rule="url">Royaume-Uni</country><wicri:regionArea>Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas</wicri:regionArea></affiliation></author><author><name sortKey="Muller, Christian P" sort="Muller, Christian P" uniqKey="Muller C" first="Christian P" last="Müller">Christian P. Müller</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Friedrich Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Friedrich Alexander University Erlangen-Nuremberg, 91054 Erlangen</wicri:regionArea></affiliation></author><author><name sortKey="Levy, Daniel" sort="Levy, Daniel" uniqKey="Levy D" first="Daniel" last="Levy">Daniel Levy</name><affiliation wicri:level="2"><nlm:affiliation>The Framingham Heart Study, Framingham, MA 01702.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>The Framingham Heart Study, Framingham</wicri:cityArea></affiliation></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom; gunter.schumann@kcl.ac.uk davo.mango@utsouthwestern.edu p.elliott@imperial.ac.uk.</nlm:affiliation><country wicri:rule="url">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27911795</idno><idno type="pmid">27911795</idno><idno type="doi">10.1073/pnas.1611243113</idno><idno type="wicri:Area/PubMed/Corpus">001495</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001495</idno><idno type="wicri:Area/PubMed/Curation">001473</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001473</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference.</title><author><name sortKey="Schumann, Gunter" sort="Schumann, Gunter" uniqKey="Schumann G" first="Gunter" last="Schumann">Gunter Schumann</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom; gunter.schumann@kcl.ac.uk davo.mango@utsouthwestern.edu p.elliott@imperial.ac.uk.</nlm:affiliation><country wicri:rule="url">Royaume-Uni</country><wicri:regionArea>Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Chunyu" sort="Liu, Chunyu" uniqKey="Liu C" first="Chunyu" last="Liu">Chunyu Liu</name><affiliation wicri:level="2"><nlm:affiliation>The Framingham Heart Study, Framingham, MA 01702.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>The Framingham Heart Study, Framingham</wicri:cityArea></affiliation></author><author><name sortKey="O Reilly, Paul" sort="O Reilly, Paul" uniqKey="O Reilly P" first="Paul" last="O'Reilly">Paul O'Reilly</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF</wicri:regionArea></affiliation></author><author><name sortKey="Gao, He" sort="Gao, He" uniqKey="Gao H" first="He" last="Gao">He Gao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG</wicri:regionArea></affiliation></author><author><name sortKey="Song, Parkyong" sort="Song, Parkyong" uniqKey="Song P" first="Parkyong" last="Song">Parkyong Song</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas</wicri:cityArea></affiliation></author><author><name sortKey="Xu, Bing" sort="Xu, Bing" uniqKey="Xu B" first="Bing" last="Xu">Bing Xu</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF</wicri:regionArea></affiliation></author><author><name sortKey="Ruggeri, Barbara" sort="Ruggeri, Barbara" uniqKey="Ruggeri B" first="Barbara" last="Ruggeri">Barbara Ruggeri</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF</wicri:regionArea></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Jia, Tianye" sort="Jia, Tianye" uniqKey="Jia T" first="Tianye" last="Jia">Tianye Jia</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF</wicri:regionArea></affiliation></author><author><name sortKey="Preis, Sarah" sort="Preis, Sarah" uniqKey="Preis S" first="Sarah" last="Preis">Sarah Preis</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Biostatistics, Boston University School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Segura Lepe, Marcelo" sort="Segura Lepe, Marcelo" uniqKey="Segura Lepe M" first="Marcelo" last="Segura Lepe">Marcelo Segura Lepe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG</wicri:regionArea></affiliation></author><author><name sortKey="Akira, Shizuo" sort="Akira, Shizuo" uniqKey="Akira S" first="Shizuo" last="Akira">Shizuo Akira</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871</wicri:regionArea></affiliation></author><author><name sortKey="Barbieri, Caterina" sort="Barbieri, Caterina" uniqKey="Barbieri C" first="Caterina" last="Barbieri">Caterina Barbieri</name><affiliation wicri:level="1"><nlm:affiliation>Division of Genetics and Cell Biology, San Raffaele Research Institute, 20132 Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Genetics and Cell Biology, San Raffaele Research Institute, 20132 Milan</wicri:regionArea></affiliation></author><author><name sortKey="Baumeister, Sebastian" sort="Baumeister, Sebastian" uniqKey="Baumeister S" first="Sebastian" last="Baumeister">Sebastian Baumeister</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald 17475, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Community Medicine, University Medicine Greifswald, Greifswald 17475</wicri:regionArea></affiliation></author><author><name sortKey="Cauchi, Stephane" sort="Cauchi, Stephane" uniqKey="Cauchi S" first="Stephane" last="Cauchi">Stephane Cauchi</name><affiliation wicri:level="1"><nlm:affiliation>CNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes, Lille 2 University, 59000 Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes, Lille 2 University, 59000 Lille</wicri:regionArea></affiliation></author><author><name sortKey="Clarke, Toni Kim" sort="Clarke, Toni Kim" uniqKey="Clarke T" first="Toni-Kim" last="Clarke">Toni-Kim Clarke</name><affiliation wicri:level="1"><nlm:affiliation>Divison of Psychiatry, University of Edinburgh, Edinburgh EH10 5HF, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Divison of Psychiatry, University of Edinburgh, Edinburgh EH10 5HF</wicri:regionArea></affiliation></author><author><name sortKey="Enroth, Stefan" sort="Enroth, Stefan" uniqKey="Enroth S" first="Stefan" last="Enroth">Stefan Enroth</name><affiliation wicri:level="1"><nlm:affiliation>Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 75108 Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 75108 Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Fischer, Krista" sort="Fischer, Krista" uniqKey="Fischer K" first="Krista" last="Fischer">Krista Fischer</name><affiliation wicri:level="1"><nlm:affiliation>Estonian Genome Center, University of Tartu, 51010 Tartu, Estonia.</nlm:affiliation><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center, University of Tartu, 51010 Tartu</wicri:regionArea></affiliation></author><author><name sortKey="H Llfors, Jenni" sort="H Llfors, Jenni" uniqKey="H Llfors J" first="Jenni" last="H Llfors">Jenni H Llfors</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Molecular Medicine, University of Helsinki, 00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine, University of Helsinki, 00290 Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Harris, Sarah E" sort="Harris, Sarah E" uniqKey="Harris S" first="Sarah E" last="Harris">Sarah E. Harris</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ</wicri:regionArea></affiliation></author><author><name sortKey="Hieber, Saskia" sort="Hieber, Saskia" uniqKey="Hieber S" first="Saskia" last="Hieber">Saskia Hieber</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Friedrich Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Friedrich Alexander University Erlangen-Nuremberg, 91054 Erlangen</wicri:regionArea></affiliation></author><author><name sortKey="Hofer, Edith" sort="Hofer, Edith" uniqKey="Hofer E" first="Edith" last="Hofer">Edith Hofer</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, 8036 Graz, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, 8036 Graz</wicri:regionArea></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Psychology, Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research, 1081 BT Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research, 1081 BT Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><affiliation wicri:level="1"><nlm:affiliation>Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 75108 Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 75108 Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Joshi, Peter K" sort="Joshi, Peter K" uniqKey="Joshi P" first="Peter K" last="Joshi">Peter K. Joshi</name><affiliation wicri:level="1"><nlm:affiliation>Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG</wicri:regionArea></affiliation></author><author><name sortKey="Kaartinen, Niina" sort="Kaartinen, Niina" uniqKey="Kaartinen N" first="Niina" last="Kaartinen">Niina Kaartinen</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health and Welfare, 00271 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare, 00271 Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Laitinen, Jaana" sort="Laitinen, Jaana" uniqKey="Laitinen J" first="Jaana" last="Laitinen">Jaana Laitinen</name><affiliation wicri:level="1"><nlm:affiliation>Quantified Employee-Unit, Finnish Institute of Occupational Health, 00250 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Quantified Employee-Unit, Finnish Institute of Occupational Health, 00250 Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Lemaitre, Rozenn" sort="Lemaitre, Rozenn" uniqKey="Lemaitre R" first="Rozenn" last="Lemaitre">Rozenn Lemaitre</name><affiliation wicri:level="2"><nlm:affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Loukola, Anu" sort="Loukola, Anu" uniqKey="Loukola A" first="Anu" last="Loukola">Anu Loukola</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Molecular Medicine, University of Helsinki, 00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine, University of Helsinki, 00290 Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Luan, Jian An" sort="Luan, Jian An" uniqKey="Luan J" first="Jian'An" last="Luan">Jian'An Luan</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ</wicri:regionArea></affiliation></author><author><name sortKey="Lyytik Inen, Leo Pekka" sort="Lyytik Inen, Leo Pekka" uniqKey="Lyytik Inen L" first="Leo-Pekka" last="Lyytik Inen">Leo-Pekka Lyytik Inen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere 33520, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere 33520</wicri:regionArea></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation wicri:level="1"><nlm:affiliation>Department of Twin Research and Genetic Epidemiology, King's College, London SE1 7EH, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College, London SE1 7EH</wicri:regionArea></affiliation></author><author><name sortKey="Manichaikul, Ani" sort="Manichaikul, Ani" uniqKey="Manichaikul A" first="Ani" last="Manichaikul">Ani Manichaikul</name><affiliation wicri:level="2"><nlm:affiliation>Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22903.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville</wicri:cityArea></affiliation></author><author><name sortKey="Mbarek, Hamdi" sort="Mbarek, Hamdi" uniqKey="Mbarek H" first="Hamdi" last="Mbarek">Hamdi Mbarek</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Psychology, Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research, 1081 BT Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research, 1081 BT Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Milaneschi, Yuri" sort="Milaneschi, Yuri" uniqKey="Milaneschi Y" first="Yuri" last="Milaneschi">Yuri Milaneschi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Institute for Health and Care Research (EMGO) Institute for Health and Care Research and Neuroscience Campus Amsterdam, Vrije Universiteit Amsterdam University Medical Center/Geestelijke Gezondheids Zorg (GGZ) inGeest, 1081 HL Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Institute for Health and Care Research (EMGO) Institute for Health and Care Research and Neuroscience Campus Amsterdam, Vrije Universiteit Amsterdam University Medical Center/Geestelijke Gezondheids Zorg (GGZ) inGeest, 1081 HL Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Moayyeri, Alireza" sort="Moayyeri, Alireza" uniqKey="Moayyeri A" first="Alireza" last="Moayyeri">Alireza Moayyeri</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG</wicri:regionArea></affiliation></author><author><name sortKey="Mukamal, Kenneth" sort="Mukamal, Kenneth" uniqKey="Mukamal K" first="Kenneth" last="Mukamal">Kenneth Mukamal</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Nelson, Christopher" sort="Nelson, Christopher" uniqKey="Nelson C" first="Christopher" last="Nelson">Christopher Nelson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP</wicri:regionArea></affiliation></author><author><name sortKey="Nettleton, Jennifer" sort="Nettleton, Jennifer" uniqKey="Nettleton J" first="Jennifer" last="Nettleton">Jennifer Nettleton</name><affiliation wicri:level="2"><nlm:affiliation>Division of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Sciences Center, Houston, TX 77225.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Division of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Sciences Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Partinen, Eemil" sort="Partinen, Eemil" uniqKey="Partinen E" first="Eemil" last="Partinen">Eemil Partinen</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, University of Tartu, 50411 Tartu, Estonia.</nlm:affiliation><country xml:lang="fr">Estonie</country><wicri:regionArea>Faculty of Medicine, University of Tartu, 50411 Tartu</wicri:regionArea></affiliation></author><author><name sortKey="Rawal, Rajesh" sort="Rawal, Rajesh" uniqKey="Rawal R" first="Rajesh" last="Rawal">Rajesh Rawal</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Robino, Antonietta" sort="Robino, Antonietta" uniqKey="Robino A" first="Antonietta" last="Robino">Antonietta Robino</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Maternal and Child Health-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Burlo Garofolo, 34137 Trieste, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute for Maternal and Child Health-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Burlo Garofolo, 34137 Trieste</wicri:regionArea></affiliation></author><author><name sortKey="Rose, Lynda" sort="Rose, Lynda" uniqKey="Rose L" first="Lynda" last="Rose">Lynda Rose</name><affiliation wicri:level="2"><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Preventive Medicine, Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Sala, Cinzia" sort="Sala, Cinzia" uniqKey="Sala C" first="Cinzia" last="Sala">Cinzia Sala</name><affiliation wicri:level="1"><nlm:affiliation>Division of Genetics and Cell Biology, San Raffaele Research Institute, 20132 Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Genetics and Cell Biology, San Raffaele Research Institute, 20132 Milan</wicri:regionArea></affiliation></author><author><name sortKey="Satoh, Takashi" sort="Satoh, Takashi" uniqKey="Satoh T" first="Takashi" last="Satoh">Takashi Satoh</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, 8036 Graz, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, 8036 Graz</wicri:regionArea></affiliation></author><author><name sortKey="Schraut, Katharina" sort="Schraut, Katharina" uniqKey="Schraut K" first="Katharina" last="Schraut">Katharina Schraut</name><affiliation wicri:level="1"><nlm:affiliation>Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG</wicri:regionArea></affiliation></author><author><name sortKey="Scott, Robert" sort="Scott, Robert" uniqKey="Scott R" first="Robert" last="Scott">Robert Scott</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name><affiliation wicri:level="1"><nlm:affiliation>Research Institute, Icelandic Heart Association, 201 Kopavogur, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>Research Institute, Icelandic Heart Association, 201 Kopavogur</wicri:regionArea></affiliation></author><author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M" last="Starr">John M. Starr</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ</wicri:regionArea></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald 17475, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Community Medicine, University Medicine Greifswald, Greifswald 17475</wicri:regionArea></affiliation></author><author><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G" last="Uitterlinden">André G. Uitterlinden</name><affiliation wicri:level="1"><nlm:affiliation>Department of internal Medicine, Erasmus Medical Center, 3015 CN Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of internal Medicine, Erasmus Medical Center, 3015 CN Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Venturini, Cristina" sort="Venturini, Cristina" uniqKey="Venturini C" first="Cristina" last="Venturini">Cristina Venturini</name><affiliation wicri:level="1"><nlm:affiliation>Department of Twin Research and Genetic Epidemiology, King's College, London SE1 7EH, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College, London SE1 7EH</wicri:regionArea></affiliation></author><author><name sortKey="Vergnaud, Anne Claire" sort="Vergnaud, Anne Claire" uniqKey="Vergnaud A" first="Anne-Claire" last="Vergnaud">Anne-Claire Vergnaud</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG</wicri:regionArea></affiliation></author><author><name sortKey="Verweij, Niek" sort="Verweij, Niek" uniqKey="Verweij N" first="Niek" last="Verweij">Niek Verweij</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU</wicri:regionArea></affiliation></author><author><name sortKey="Vuckovic, Dragana" sort="Vuckovic, Dragana" uniqKey="Vuckovic D" first="Dragana" last="Vuckovic">Dragana Vuckovic</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Sciences, University of Trieste, 34149 Trieste, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Sciences, University of Trieste, 34149 Trieste</wicri:regionArea></affiliation></author><author><name sortKey="Wedenoja, Juho" sort="Wedenoja, Juho" uniqKey="Wedenoja J" first="Juho" last="Wedenoja">Juho Wedenoja</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health, University of Helsinki, 00014 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Public Health, University of Helsinki, 00014 Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Yengo, Loic" sort="Yengo, Loic" uniqKey="Yengo L" first="Loic" last="Yengo">Loic Yengo</name><affiliation wicri:level="1"><nlm:affiliation>CNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes, Lille 2 University, 59000 Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes, Lille 2 University, 59000 Lille</wicri:regionArea></affiliation></author><author><name sortKey="Yu, Bing" sort="Yu, Bing" uniqKey="Yu B" first="Bing" last="Yu">Bing Yu</name><affiliation wicri:level="2"><nlm:affiliation>Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77225.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Human Genetics Center, University of Texas Health Science Center at Houston, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Zhang, Weihua" sort="Zhang, Weihua" uniqKey="Zhang W" first="Weihua" last="Zhang">Weihua Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ</wicri:regionArea></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I" last="Boomsma">Dorret I. Boomsma</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Psychology, Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research, 1081 BT Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research, 1081 BT Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Chambers, John" sort="Chambers, John" uniqKey="Chambers J" first="John" last="Chambers">John Chambers</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG</wicri:regionArea></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I" last="Chasman">Daniel I. Chasman</name><affiliation wicri:level="2"><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Preventive Medicine, Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Daniela, Toniolo" sort="Daniela, Toniolo" uniqKey="Daniela T" first="Toniolo" last="Daniela">Toniolo Daniela</name><affiliation wicri:level="1"><nlm:affiliation>Division of Genetics and Cell Biology, San Raffaele Research Institute, 20132 Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Genetics and Cell Biology, San Raffaele Research Institute, 20132 Milan</wicri:regionArea></affiliation></author><author><name sortKey="De Geus, Eco" sort="De Geus, Eco" uniqKey="De Geus E" first="Eco" last="De Geus">Eco De Geus</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Psychology, Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research, 1081 BT Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research, 1081 BT Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Deary, Ian" sort="Deary, Ian" uniqKey="Deary I" first="Ian" last="Deary">Ian Deary</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ</wicri:regionArea></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G" last="Eriksson">Johan G. Eriksson</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health and Welfare, 00271 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare, 00271 Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation wicri:level="1"><nlm:affiliation>Estonian Genome Center, University of Tartu, 51010 Tartu, Estonia.</nlm:affiliation><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center, University of Tartu, 51010 Tartu</wicri:regionArea></affiliation></author><author><name sortKey="Eulenburg, Volker" sort="Eulenburg, Volker" uniqKey="Eulenburg V" first="Volker" last="Eulenburg">Volker Eulenburg</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Biochemistry and Molecular Medicine, Friedrich Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Biochemistry and Molecular Medicine, Friedrich Alexander University Erlangen-Nuremberg, 91054 Erlangen</wicri:regionArea></affiliation></author><author><name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H" last="Franco">Oscar H. Franco</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation wicri:level="1"><nlm:affiliation>CNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes, Lille 2 University, 59000 Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes, Lille 2 University, 59000 Lille</wicri:regionArea></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Grabe, Hans J" sort="Grabe, Hans J" uniqKey="Grabe H" first="Hans J" last="Grabe">Hans J. Grabe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475 Greifswald, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475 Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation wicri:level="1"><nlm:affiliation>Research Institute, Icelandic Heart Association, 201 Kopavogur, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>Research Institute, Icelandic Heart Association, 201 Kopavogur</wicri:regionArea></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation wicri:level="1"><nlm:affiliation>Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 75108 Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 75108 Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B" last="Harris">Tamara B. Harris</name><affiliation wicri:level="2"><nlm:affiliation>National Institute on Aging, NIH, Bethesda, MD 20892.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>National Institute on Aging, NIH, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Obstetrics and Gynecology, Oulu University Hospital, 90029 Oulu, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Obstetrics and Gynecology, Oulu University Hospital, 90029 Oulu</wicri:regionArea></affiliation></author><author><name sortKey="Heath, Andrew C" sort="Heath, Andrew C" uniqKey="Heath A" first="Andrew C" last="Heath">Andrew C. Heath</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO 63110.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Department of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis</wicri:cityArea></affiliation></author><author><name sortKey="Hocking, Lynne" sort="Hocking, Lynne" uniqKey="Hocking L" first="Lynne" last="Hocking">Lynne Hocking</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD</wicri:regionArea></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Huth, Cornelia" sort="Huth, Cornelia" uniqKey="Huth C" first="Cornelia" last="Huth">Cornelia Huth</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, D-85764 Neuherberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, D-85764 Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG</wicri:regionArea></affiliation></author><author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J Wouter" last="Jukema">J Wouter Jukema</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Molecular Medicine, University of Helsinki, 00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine, University of Helsinki, 00290 Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S" last="Kooner">Jaspal S. Kooner</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW</wicri:regionArea></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltan" last="Kutalik">Zoltan Kutalik</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudoise, 1010 Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudoise, 1010 Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name><affiliation wicri:level="1"><nlm:affiliation>Folkhälsan Research Centre, Public Health Research, 00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Folkhälsan Research Centre, Public Health Research, 00290 Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ</wicri:regionArea></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere 33520, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere 33520</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name><affiliation wicri:level="2"><nlm:affiliation>Wake Forest School of Medicine, Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Wake Forest School of Medicine, Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem</wicri:cityArea></affiliation></author><author><name sortKey="Madden, Pamela A F" sort="Madden, Pamela A F" uniqKey="Madden P" first="Pamela A F" last="Madden">Pamela A F. Madden</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Department of Psychiatry, Washington University School of Medicine, St. Louis</wicri:cityArea></affiliation></author><author><name sortKey="Martin, Nicholas" sort="Martin, Nicholas" uniqKey="Martin N" first="Nicholas" last="Martin">Nicholas Martin</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology, Queensland Institute of Medical Research Berghofer Medical Research Institute, Herston, Brisbane QLD 4029, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology, Queensland Institute of Medical Research Berghofer Medical Research Institute, Herston, Brisbane QLD 4029</wicri:regionArea></affiliation></author><author><name sortKey="Morrison, Alanna" sort="Morrison, Alanna" uniqKey="Morrison A" first="Alanna" last="Morrison">Alanna Morrison</name><affiliation wicri:level="2"><nlm:affiliation>Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77225.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Human Genetics Center, University of Texas Health Science Center at Houston, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Penninx, Brenda" sort="Penninx, Brenda" uniqKey="Penninx B" first="Brenda" last="Penninx">Brenda Penninx</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Institute for Health and Care Research (EMGO) Institute for Health and Care Research and Neuroscience Campus Amsterdam, Vrije Universiteit Amsterdam University Medical Center/Geestelijke Gezondheids Zorg (GGZ) inGeest, 1081 HL Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Institute for Health and Care Research (EMGO) Institute for Health and Care Research and Neuroscience Campus Amsterdam, Vrije Universiteit Amsterdam University Medical Center/Geestelijke Gezondheids Zorg (GGZ) inGeest, 1081 HL Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Pirastu, Nicola" sort="Pirastu, Nicola" uniqKey="Pirastu N" first="Nicola" last="Pirastu">Nicola Pirastu</name><affiliation wicri:level="1"><nlm:affiliation>Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG</wicri:regionArea></affiliation></author><author><name sortKey="Psaty, Bruce" sort="Psaty, Bruce" uniqKey="Psaty B" first="Bruce" last="Psaty">Bruce Psaty</name><affiliation wicri:level="2"><nlm:affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, University of Turku, Turku 20520, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, University of Turku, Turku 20520</wicri:regionArea></affiliation></author><author><name sortKey="Ridker, Paul" sort="Ridker, Paul" uniqKey="Ridker P" first="Paul" last="Ridker">Paul Ridker</name><affiliation wicri:level="2"><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Preventive Medicine, Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Rose, Richard" sort="Rose, Richard" uniqKey="Rose R" first="Richard" last="Rose">Richard Rose</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Indiana</region></placeName><wicri:cityArea>Department of Psychological and Brain Sciences, Indiana University, Bloomington</wicri:cityArea></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I" last="Rotter">Jerome I. Rotter</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles Medical Center, Torrance, CA 90509.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles Medical Center, Torrance</wicri:cityArea></affiliation></author><author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J" last="Samani">Nilesh J. Samani</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, 8010 Graz, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, 8010 Graz</wicri:regionArea></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D" last="Spector">Tim D. Spector</name><affiliation wicri:level="1"><nlm:affiliation>Department of Twin Research and Genetic Epidemiology, King's College, London SE1 7EH, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College, London SE1 7EH</wicri:regionArea></affiliation></author><author><name sortKey="Stott, David" sort="Stott, David" uniqKey="Stott D" first="David" last="Stott">David Stott</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow G31 2ER, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow G31 2ER</wicri:regionArea></affiliation></author><author><name sortKey="Strachan, David" sort="Strachan, David" uniqKey="Strachan D" first="David" last="Strachan">David Strachan</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, St. George's, University of London, London SW17 0RE, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Population Health Research Institute, St. George's, University of London, London SW17 0RE</wicri:regionArea></affiliation></author><author><name sortKey="Tzoulaki, Ioanna" sort="Tzoulaki, Ioanna" uniqKey="Tzoulaki I" first="Ioanna" last="Tzoulaki">Ioanna Tzoulaki</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Marques Vidal, Pedro" sort="Marques Vidal, Pedro" uniqKey="Marques Vidal P" first="Pedro" last="Marques-Vidal">Pedro Marques-Vidal</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Internal Medicine, Lausanne University Hospital, 1011 Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Medicine, Internal Medicine, Lausanne University Hospital, 1011 Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Internal Medicine, Lausanne University Hospital, 1011 Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Medicine, Internal Medicine, Lausanne University Hospital, 1011 Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ</wicri:regionArea></affiliation></author><author><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B" last="Whitfield">John B. Whitfield</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology, Queensland Institute of Medical Research Berghofer Medical Research Institute, Herston, Brisbane QLD 4029, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology, Queensland Institute of Medical Research Berghofer Medical Research Institute, Herston, Brisbane QLD 4029</wicri:regionArea></affiliation></author><author><name sortKey="Wilson, James" sort="Wilson, James" uniqKey="Wilson J" first="James" last="Wilson">James Wilson</name><affiliation wicri:level="1"><nlm:affiliation>Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG</wicri:regionArea></affiliation></author><author><name sortKey="Wolffenbuttel, Bruce" sort="Wolffenbuttel, Bruce" uniqKey="Wolffenbuttel B" first="Bruce" last="Wolffenbuttel">Bruce Wolffenbuttel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Endocrinology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Endocrinology, University Medical Center Groningen, University of Groningen, 9700RB Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Bakalkin, Georgy" sort="Bakalkin, Georgy" uniqKey="Bakalkin G" first="Georgy" last="Bakalkin">Georgy Bakalkin</name><affiliation wicri:level="1"><nlm:affiliation>Division of Biological Research on Drug Dependence, Department of Pharmaceutical, Biosciences, Uppsala University, 751 24 Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Biological Research on Drug Dependence, Department of Pharmaceutical, Biosciences, Uppsala University, 751 24 Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Evangelou, Evangelos" sort="Evangelou, Evangelos" uniqKey="Evangelou E" first="Evangelos" last="Evangelou">Evangelos Evangelou</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Yun" sort="Liu, Yun" uniqKey="Liu Y" first="Yun" last="Liu">Yun Liu</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, 200032 Shanghai, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, 200032 Shanghai</wicri:regionArea></affiliation></author><author><name sortKey="Rice, Kenneth M" sort="Rice, Kenneth M" uniqKey="Rice K" first="Kenneth M" last="Rice">Kenneth M. Rice</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biostatistics, University of Washington, Seattle, WA 98195.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Department of Biostatistics, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Desrivieres, Sylvane" sort="Desrivieres, Sylvane" uniqKey="Desrivieres S" first="Sylvane" last="Desrivières">Sylvane Desrivières</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF</wicri:regionArea></affiliation></author><author><name sortKey="Kliewer, Steven A" sort="Kliewer, Steven A" uniqKey="Kliewer S" first="Steven A" last="Kliewer">Steven A. Kliewer</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas</wicri:cityArea></affiliation></author><author><name sortKey="Mangelsdorf, David J" sort="Mangelsdorf, David J" uniqKey="Mangelsdorf D" first="David J" last="Mangelsdorf">David J. Mangelsdorf</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390; gunter.schumann@kcl.ac.uk davo.mango@utsouthwestern.edu p.elliott@imperial.ac.uk.</nlm:affiliation><country wicri:rule="url">Royaume-Uni</country><wicri:regionArea>Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas</wicri:regionArea></affiliation></author><author><name sortKey="Muller, Christian P" sort="Muller, Christian P" uniqKey="Muller C" first="Christian P" last="Müller">Christian P. Müller</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Friedrich Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Friedrich Alexander University Erlangen-Nuremberg, 91054 Erlangen</wicri:regionArea></affiliation></author><author><name sortKey="Levy, Daniel" sort="Levy, Daniel" uniqKey="Levy D" first="Daniel" last="Levy">Daniel Levy</name><affiliation wicri:level="2"><nlm:affiliation>The Framingham Heart Study, Framingham, MA 01702.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>The Framingham Heart Study, Framingham</wicri:cityArea></affiliation></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom; gunter.schumann@kcl.ac.uk davo.mango@utsouthwestern.edu p.elliott@imperial.ac.uk.</nlm:affiliation><country wicri:rule="url">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG</wicri:regionArea></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="eISSN">1091-6490</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Excessive alcohol consumption is a major public health problem worldwide. Although drinking habits are known to be inherited, few genes have been identified that are robustly linked to alcohol drinking. We conducted a genome-wide association metaanalysis and replication study among >105,000 individuals of European ancestry and identified β-Klotho (KLB) as a locus associated with alcohol consumption (rs11940694; P = 9.2 × 10(-12)). β-Klotho is an obligate coreceptor for the hormone FGF21, which is secreted from the liver and implicated in macronutrient preference in humans. We show that brain-specific β-Klotho KO mice have an increased alcohol preference and that FGF21 inhibits alcohol drinking by acting on the brain. These data suggest that a liver-brain endocrine axis may play an important role in the regulation of alcohol drinking behavior and provide a unique pharmacologic target for reducing alcohol consumption.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">27911795</PMID><DateCreated><Year>2016</Year><Month>12</Month><Day>02</Day></DateCreated><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1091-6490</ISSN><JournalIssue CitedMedium="Internet"><Volume>113</Volume><Issue>50</Issue><PubDate><Year>2016</Year><Month>Dec</Month><Day>13</Day></PubDate></JournalIssue><Title>Proceedings of the National Academy of Sciences of the United States of America</Title><ISOAbbreviation>Proc. Natl. Acad. Sci. U.S.A.</ISOAbbreviation></Journal><ArticleTitle>KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference.</ArticleTitle><Pagination><MedlinePgn>14372-14377</MedlinePgn></Pagination><Abstract><AbstractText>Excessive alcohol consumption is a major public health problem worldwide. Although drinking habits are known to be inherited, few genes have been identified that are robustly linked to alcohol drinking. We conducted a genome-wide association metaanalysis and replication study among >105,000 individuals of European ancestry and identified β-Klotho (KLB) as a locus associated with alcohol consumption (rs11940694; P = 9.2 × 10(-12)). β-Klotho is an obligate coreceptor for the hormone FGF21, which is secreted from the liver and implicated in macronutrient preference in humans. We show that brain-specific β-Klotho KO mice have an increased alcohol preference and that FGF21 inhibits alcohol drinking by acting on the brain. These data suggest that a liver-brain endocrine axis may play an important role in the regulation of alcohol drinking behavior and provide a unique pharmacologic target for reducing alcohol consumption.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schumann</LastName><ForeName>Gunter</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom; gunter.schumann@kcl.ac.uk davo.mango@utsouthwestern.edu p.elliott@imperial.ac.uk.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Chunyu</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>The Framingham Heart Study, Framingham, MA 01702.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD 20824.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O'Reilly</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gao</LastName><ForeName>He</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Medical Research Council-Public Health England Centre for Environment and Health, Imperial College London, London W2 1PG, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Song</LastName><ForeName>Parkyong</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Bing</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ruggeri</LastName><ForeName>Barbara</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amin</LastName><ForeName>Najaf</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jia</LastName><ForeName>Tianye</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Preis</LastName><ForeName>Sarah</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Segura Lepe</LastName><ForeName>Marcelo</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Section of Bioinformatics, Bayer Pharma AG, 13342 Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Akira</LastName><ForeName>Shizuo</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barbieri</LastName><ForeName>Caterina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Division of Genetics and Cell Biology, San Raffaele Research Institute, 20132 Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baumeister</LastName><ForeName>Sebastian</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald 17475, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology and Preventive Medicine, University of Regensburg, 93053 Regensburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cauchi</LastName><ForeName>Stephane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>CNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes, Lille 2 University, 59000 Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clarke</LastName><ForeName>Toni-Kim</ForeName><Initials>TK</Initials><AffiliationInfo><Affiliation>Divison of Psychiatry, University of Edinburgh, Edinburgh EH10 5HF, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Enroth</LastName><ForeName>Stefan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 75108 Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fischer</LastName><ForeName>Krista</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Estonian Genome Center, University of Tartu, 51010 Tartu, Estonia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hällfors</LastName><ForeName>Jenni</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute for Molecular Medicine, University of Helsinki, 00290 Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harris</LastName><ForeName>Sarah E</ForeName><Initials>SE</Initials><AffiliationInfo><Affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hieber</LastName><ForeName>Saskia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, Friedrich Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hofer</LastName><ForeName>Edith</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, 8036 Graz, Austria.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Medical Informatics, Statistics and Documentation, Medical University Graz, 8036 Graz, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hottenga</LastName><ForeName>Jouke-Jan</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>Department of Biological Psychology, Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research, 1081 BT Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Johansson</LastName><ForeName>Åsa</ForeName><Initials>Å</Initials><AffiliationInfo><Affiliation>Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 75108 Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Joshi</LastName><ForeName>Peter K</ForeName><Initials>PK</Initials><AffiliationInfo><Affiliation>Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kaartinen</LastName><ForeName>Niina</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>National Institute for Health and Welfare, 00271 Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laitinen</LastName><ForeName>Jaana</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Quantified Employee-Unit, Finnish Institute of Occupational Health, 00250 Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lemaitre</LastName><ForeName>Rozenn</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Loukola</LastName><ForeName>Anu</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute for Molecular Medicine, University of Helsinki, 00290 Helsinki, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Public Health, University of Helsinki, 00014 Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Luan</LastName><ForeName>Jian'an</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Medical Research Council Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lyytikäinen</LastName><ForeName>Leo-Pekka</ForeName><Initials>LP</Initials><AffiliationInfo><Affiliation>Department of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere 33520, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mangino</LastName><ForeName>Massimo</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Twin Research and Genetic Epidemiology, King's College, London SE1 7EH, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>National Institute for Health Research Biomedical Research Centre at Guy's and St. Thomas' Foundation Trust, London SE1 9RT, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manichaikul</LastName><ForeName>Ani</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22903.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Biostatistics Section, Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22903.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mbarek</LastName><ForeName>Hamdi</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Biological Psychology, Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research, 1081 BT Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Milaneschi</LastName><ForeName>Yuri</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Institute for Health and Care Research (EMGO) Institute for Health and Care Research and Neuroscience Campus Amsterdam, Vrije Universiteit Amsterdam University Medical Center/Geestelijke Gezondheids Zorg (GGZ) inGeest, 1081 HL Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moayyeri</LastName><ForeName>Alireza</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Health Informatics, University College London, London NW1 2DA, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Farr Institute of Health Informatics Research, University College London Institute of Health Informatics, London NW1 2DA, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mukamal</LastName><ForeName>Kenneth</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nelson</LastName><ForeName>Christopher</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nettleton</LastName><ForeName>Jennifer</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Division of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Sciences Center, Houston, TX 77225.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Partinen</LastName><ForeName>Eemil</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, University of Tartu, 50411 Tartu, Estonia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rawal</LastName><ForeName>Rajesh</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Robino</LastName><ForeName>Antonietta</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute for Maternal and Child Health-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Burlo Garofolo, 34137 Trieste, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rose</LastName><ForeName>Lynda</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sala</LastName><ForeName>Cinzia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Division of Genetics and Cell Biology, San Raffaele Research Institute, 20132 Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Satoh</LastName><ForeName>Takashi</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmidt</LastName><ForeName>Reinhold</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, 8036 Graz, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schraut</LastName><ForeName>Katharina</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scott</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>Albert Vernon</ForeName><Initials>AV</Initials><AffiliationInfo><Affiliation>Research Institute, Icelandic Heart Association, 201 Kopavogur, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Starr</LastName><ForeName>John M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Alzheimer Scotland Research Centre, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Teumer</LastName><ForeName>Alexander</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald 17475, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trompet</LastName><ForeName>Stella</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Uitterlinden</LastName><ForeName>André G</ForeName><Initials>AG</Initials><AffiliationInfo><Affiliation>Department of internal Medicine, Erasmus Medical Center, 3015 CN Rotterdam, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Venturini</LastName><ForeName>Cristina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Twin Research and Genetic Epidemiology, King's College, London SE1 7EH, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vergnaud</LastName><ForeName>Anne-Claire</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Verweij</LastName><ForeName>Niek</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vitart</LastName><ForeName>Veronique</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Medical Research Council Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vuckovic</LastName><ForeName>Dragana</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Medical Sciences, University of Trieste, 34149 Trieste, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wedenoja</LastName><ForeName>Juho</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Public Health, University of Helsinki, 00014 Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yengo</LastName><ForeName>Loic</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>CNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes, Lille 2 University, 59000 Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Bing</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77225.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Epidemiology, University of Texas Health Science Center at Houston, Houston, TX 77225.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Weihua</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Jing Hua</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boomsma</LastName><ForeName>Dorret I</ForeName><Initials>DI</Initials><AffiliationInfo><Affiliation>Department of Biological Psychology, Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research, 1081 BT Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chambers</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Imperial College Healthcare National Health Service Trust, London W12 0HS, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chasman</LastName><ForeName>Daniel I</ForeName><Initials>DI</Initials><AffiliationInfo><Affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Harvard Medical School, Boston, MA 02115.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Daniela</LastName><ForeName>Toniolo</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Division of Genetics and Cell Biology, San Raffaele Research Institute, 20132 Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Geus</LastName><ForeName>Eco</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Biological Psychology, Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research, 1081 BT Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deary</LastName><ForeName>Ian</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Psychology, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eriksson</LastName><ForeName>Johan G</ForeName><Initials>JG</Initials><AffiliationInfo><Affiliation>National Institute for Health and Welfare, 00271 Helsinki, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of General Practice and Primary Health Care, University of Helsinki, 00014 Helsinki, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Unit of General Practice, Helsinki University Central Hospital, 00014 Helsinki, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Folkhälsan Research Centre, Public Health Research, 00290 Helsinki, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Vasa Central Hospital, 65130 Vasa, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Esko</LastName><ForeName>Tõnu</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Estonian Genome Center, University of Tartu, 51010 Tartu, Estonia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eulenburg</LastName><ForeName>Volker</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Institute for Biochemistry and Molecular Medicine, Friedrich Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Franco</LastName><ForeName>Oscar H</ForeName><Initials>OH</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Froguel</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>CNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes, Lille 2 University, 59000 Lille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Genomics of Common Disease, School of Public Health, Imperial College London, London W12 0HR, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gieger</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grabe</LastName><ForeName>Hans J</ForeName><Initials>HJ</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475 Greifswald, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gudnason</LastName><ForeName>Vilmundur</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Research Institute, Icelandic Heart Association, 201 Kopavogur, Iceland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gyllensten</LastName><ForeName>Ulf</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 75108 Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harris</LastName><ForeName>Tamara B</ForeName><Initials>TB</Initials><AffiliationInfo><Affiliation>National Institute on Aging, NIH, Bethesda, MD 20892.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hartikainen</LastName><ForeName>Anna-Liisa</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology, Oulu University Hospital, 90029 Oulu, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Medical Research Center, University of Oulu, 90014 Oulu, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Unit of Primary Care, Oulu University Hospital, 90220 Oulu, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heath</LastName><ForeName>Andrew C</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO 63110.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hocking</LastName><ForeName>Lynne</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hofman</LastName><ForeName>Albert</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huth</LastName><ForeName>Cornelia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, D-85764 Neuherberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jarvelin</LastName><ForeName>Marjo-Riitta</ForeName><Initials>MR</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Unit of Primary Care, Oulu University Hospital, 90220 Oulu, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center for Life Course Epidemiology, Faculty of Medicine, University of Oulu, Oulu FI-90014, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Biocenter Oulu, University of Oulu, Oulu FI-90014, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jukema</LastName><ForeName>J Wouter</ForeName><Initials>JW</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kaprio</LastName><ForeName>Jaakko</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute for Molecular Medicine, University of Helsinki, 00290 Helsinki, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>National Institute for Health and Welfare, 00271 Helsinki, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Public Health, University of Helsinki, 00014 Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kooner</LastName><ForeName>Jaspal S</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Imperial College Healthcare National Health Service Trust, London W12 0HS, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculty of Medicine, National Heart & Lung Institute, Cardiovascular Science, Hammersmith Hospital, Imperial College London, London W12 0NN, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kutalik</LastName><ForeName>Zoltan</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudoise, 1010 Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lahti</LastName><ForeName>Jari</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Folkhälsan Research Centre, Public Health Research, 00290 Helsinki, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Collegium for Advanced Studies, University of Helsinki, 00014 Helsinki, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Behavioural Sciences, University of Helsinki, 00014 Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Langenberg</LastName><ForeName>Claudia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Medical Research Council Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lehtimäki</LastName><ForeName>Terho</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere 33520, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Yongmei</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Wake Forest School of Medicine, Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Madden</LastName><ForeName>Pamela A F</ForeName><Initials>PA</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martin</LastName><ForeName>Nicholas</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Genetic Epidemiology, Queensland Institute of Medical Research Berghofer Medical Research Institute, Herston, Brisbane QLD 4029, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morrison</LastName><ForeName>Alanna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77225.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Penninx</LastName><ForeName>Brenda</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Institute for Health and Care Research (EMGO) Institute for Health and Care Research and Neuroscience Campus Amsterdam, Vrije Universiteit Amsterdam University Medical Center/Geestelijke Gezondheids Zorg (GGZ) inGeest, 1081 HL Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pirastu</LastName><ForeName>Nicola</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Sciences, University of Trieste, 34149 Trieste, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Psaty</LastName><ForeName>Bruce</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology, University of Washington, Seattle, WA 98195.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Health Services, University of Washington, Seattle, WA 98195.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Group Health Cooperative, Group Health Research Institute, Seattle, WA 98101.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raitakari</LastName><ForeName>Olli</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, University of Turku, Turku 20520, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku 20520, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ridker</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Harvard Medical School, Boston, MA 02115.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rose</LastName><ForeName>Richard</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rotter</LastName><ForeName>Jerome I</ForeName><Initials>JI</Initials><AffiliationInfo><Affiliation>Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles Medical Center, Torrance, CA 90509.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Samani</LastName><ForeName>Nilesh J</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmidt</LastName><ForeName>Helena</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, 8010 Graz, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spector</LastName><ForeName>Tim D</ForeName><Initials>TD</Initials><AffiliationInfo><Affiliation>Department of Twin Research and Genetic Epidemiology, King's College, London SE1 7EH, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stott</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow G31 2ER, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Strachan</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Population Health Research Institute, St. George's, University of London, London SW17 0RE, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tzoulaki</LastName><ForeName>Ioanna</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Medical Research Council-Public Health England Centre for Environment and Health, Imperial College London, London W2 1PG, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Hygiene and Epidemiology, University of Ioannina Medical School, 45110 Ioannina, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van der Harst</LastName><ForeName>Pim</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Genetics, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute of The Netherlands-Netherlands Heart Institute, 3511GC Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Duijn</LastName><ForeName>Cornelia M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marques-Vidal</LastName><ForeName>Pedro</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Medicine, Internal Medicine, Lausanne University Hospital, 1011 Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vollenweider</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Medicine, Internal Medicine, Lausanne University Hospital, 1011 Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wareham</LastName><ForeName>Nicholas J</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Whitfield</LastName><ForeName>John B</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>Genetic Epidemiology, Queensland Institute of Medical Research Berghofer Medical Research Institute, Herston, Brisbane QLD 4029, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wilson</LastName><ForeName>James</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Medical Research Council Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wolffenbuttel</LastName><ForeName>Bruce</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bakalkin</LastName><ForeName>Georgy</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Division of Biological Research on Drug Dependence, Department of Pharmaceutical, Biosciences, Uppsala University, 751 24 Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Evangelou</LastName><ForeName>Evangelos</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Hygiene and Epidemiology, University of Ioannina Medical School, 45110 Ioannina, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Yun</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, 200032 Shanghai, People's Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, 200032 Shanghai, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rice</LastName><ForeName>Kenneth M</ForeName><Initials>KM</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, University of Washington, Seattle, WA 98195.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Desrivières</LastName><ForeName>Sylvane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kliewer</LastName><ForeName>Steven A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mangelsdorf</LastName><ForeName>David J</ForeName><Initials>DJ</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-4355-0796</Identifier><AffiliationInfo><Affiliation>Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390; gunter.schumann@kcl.ac.uk davo.mango@utsouthwestern.edu p.elliott@imperial.ac.uk.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Müller</LastName><ForeName>Christian P</ForeName><Initials>CP</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, Friedrich Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Levy</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>The Framingham Heart Study, Framingham, MA 01702.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD 20824.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Elliott</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom; gunter.schumann@kcl.ac.uk davo.mango@utsouthwestern.edu p.elliott@imperial.ac.uk.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Medical Research Council-Public Health England Centre for Environment and Health, Imperial College London, London W2 1PG, United Kingdom.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 HL120393</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 HL130114</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>MR/L01632X/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>UL1 TR000124</GrantID><Acronym>TR</Acronym><Agency>NCATS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>MR/L01341X/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MR/K026992/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MC_UU_12015/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>R01 HL105756</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 DK063491</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CZD/16/6/4</GrantID><Agency>Chief Scientist Office</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MC_PC_U127561128</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>UM1 CA182913</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AA012502</GrantID><Acronym>AA</Acronym><Agency>NIAAA NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>11</Month><Day>28</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Proc Natl Acad Sci U S A</MedlineTA><NlmUniqueID>7505876</NlmUniqueID><ISSNLinking>0027-8424</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Stud Alcohol. 1991 Jul;52(4):345-52</RefSource><PMID Version="1">1875708</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Epidemiol. 2007 Jun 1;165(11):1328-35</RefSource><PMID Version="1">17372189</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2013 Sep;19(9):1147-52</RefSource><PMID Version="1">23933984</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Diabetes. 2014 Dec;63(12):4064-75</RefSource><PMID Version="1">25024372</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Psychiatry. 2012 Apr;17(4):445-50</RefSource><PMID Version="1">21968928</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2015 Mar;47(3):291-5</RefSource><PMID Version="1">25642630</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Annu Rev Physiol. 2016;78:223-41</RefSource><PMID Version="1">26654352</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br Med J (Clin Res Ed). 1981 Jun 6;282(6279):1847-51</RefSource><PMID Version="1">6786649</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Endocrinology. 2015 Jul;156(7):2470-81</RefSource><PMID Version="1">25924103</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Bioinformatics. 2010 Sep 1;26(17):2190-1</RefSource><PMID Version="1">20616382</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trends Endocrinol Metab. 2015 Jan;26(1):22-9</RefSource><PMID Version="1">25476453</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trends Neurosci. 2007 Aug;30(8):399-406</RefSource><PMID Version="1">17629579</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Metab. 2014 Oct 7;20(4):670-7</RefSource><PMID Version="1">25130400</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Metab. 2016 Feb 9;23 (2):344-9</RefSource><PMID Version="1">26724861</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>FEBS Lett. 2009 Sep 3;583(17):2882-6</RefSource><PMID Version="1">19660458</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hum Mol Genet. 2013 May 1;22(9):1895-902</RefSource><PMID Version="1">23372041</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2011;6(8):e22976</RefSource><PMID Version="1">21829679</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Endocrinology. 2009 Dec;150(12):5341-50</RefSource><PMID Version="1">19837871</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7119-24</RefSource><PMID Version="1">21471458</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Metab. 2016 Feb 9;23 (2):335-43</RefSource><PMID Version="1">26724858</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Metab. 2014 Oct 08;4(1):51-7</RefSource><PMID Version="1">25685689</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2009 Jun 27;373(9682):2223-33</RefSource><PMID Version="1">19560604</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Behav Brain Sci. 2011 Dec;34(6):293-310</RefSource><PMID Version="1">22074962</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Lipid Res. 2015 Aug;56(8):1481-91</RefSource><PMID Version="1">26092866</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Postgrad Med J. 2001 Dec;77(914):747-52</RefSource><PMID Version="1">11723311</PMID></CommentsCorrections></CommentsCorrectionsList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">FGF21</Keyword><Keyword MajorTopicYN="N">alcohol consumption</Keyword><Keyword MajorTopicYN="N">human</Keyword><Keyword MajorTopicYN="N">mouse model</Keyword><Keyword MajorTopicYN="N">β-Klotho</Keyword></KeywordList><CoiStatement>B. Psaty serves on the Data and Safety Monitoring Board for a clinical trial funded by the manufacturer (Zoll LifeCor) and the Steering Committee of the Yale Open Data Access project funded by Johnson & Johnson. D.J.M. serves on the scientific advisory board of Metacrine. The other authors report no competing financial interests.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>12</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>12</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>12</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27911795</ArticleId><ArticleId IdType="pii">1611243113</ArticleId><ArticleId IdType="doi">10.1073/pnas.1611243113</ArticleId><ArticleId IdType="pmc">PMC5167198</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001473 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 001473 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:27911795
|texte= KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:27911795" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |