Priming of transcriptional memory responses via the chromatin accessibility landscape in T cells.
Identifieur interne : 000F95 ( PubMed/Curation ); précédent : 000F94; suivant : 000F96Priming of transcriptional memory responses via the chromatin accessibility landscape in T cells.
Auteurs : Wen Juan Tu [Australie] ; Kristine Hardy [Australie] ; Christopher R. Sutton [Australie] ; Robert Mccuaig [Australie] ; Jasmine Li [Australie] ; Jenny Dunn [Australie] ; Abel Tan [Australie] ; Vedran Brezar [France] ; Melanie Morris [Australie] ; Gareth Denyer [Australie] ; Sau Kuen Lee [Australie] ; Stephen J. Turner [Australie] ; Nabila Seddiki [France] ; Corey Smith [Australie] ; Rajiv Khanna [Australie] ; Sudha Rao [Australie]Source :
- Scientific reports [ 2045-2322 ] ; 2017.
Abstract
Memory T cells exhibit transcriptional memory and "remember" their previous pathogenic encounter to increase transcription on re-infection. However, how this transcriptional priming response is regulated is unknown. Here we performed global FAIRE-seq profiling of chromatin accessibility in a human T cell transcriptional memory model. Primary activation induced persistent accessibility changes, and secondary activation induced secondary-specific opening of previously less accessible regions associated with enhanced expression of memory-responsive genes. Increased accessibility occurred largely in distal regulatory regions and was associated with increased histone acetylation and relative H3.3 deposition. The enhanced re-stimulation response was linked to the strength of initial PKC-induced signalling, and PKC-sensitive increases in accessibility upon initial stimulation showed higher accessibility on re-stimulation. While accessibility maintenance was associated with ETS-1, accessibility at re-stimulation-specific regions was linked to NFAT, especially in combination with ETS-1, EGR, GATA, NFκB, and NR4A. Furthermore, NFATC1 was directly regulated by ETS-1 at an enhancer region. In contrast to the factors that increased accessibility, signalling from bHLH and ZEB family members enhanced decreased accessibility upon re-stimulation. Interplay between distal regulatory elements, accessibility, and the combined action of sequence-specific transcription factors allows transcriptional memory-responsive genes to "remember" their initial environmental encounter.
DOI: 10.1038/srep44825
PubMed: 28317936
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000F98
Links to Exploration step
pubmed:28317936Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Priming of transcriptional memory responses via the chromatin accessibility landscape in T cells.</title>
<author><name sortKey="Tu, Wen Juan" sort="Tu, Wen Juan" uniqKey="Tu W" first="Wen Juan" last="Tu">Wen Juan Tu</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hardy, Kristine" sort="Hardy, Kristine" uniqKey="Hardy K" first="Kristine" last="Hardy">Kristine Hardy</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sutton, Christopher R" sort="Sutton, Christopher R" uniqKey="Sutton C" first="Christopher R" last="Sutton">Christopher R. Sutton</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mccuaig, Robert" sort="Mccuaig, Robert" uniqKey="Mccuaig R" first="Robert" last="Mccuaig">Robert Mccuaig</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Li, Jasmine" sort="Li, Jasmine" uniqKey="Li J" first="Jasmine" last="Li">Jasmine Li</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, Biomedical Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology, Biomedical Discovery Institute, Monash University, Clayton, Victoria 3800</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dunn, Jenny" sort="Dunn, Jenny" uniqKey="Dunn J" first="Jenny" last="Dunn">Jenny Dunn</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tan, Abel" sort="Tan, Abel" uniqKey="Tan A" first="Abel" last="Tan">Abel Tan</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brezar, Vedran" sort="Brezar, Vedran" uniqKey="Brezar V" first="Vedran" last="Brezar">Vedran Brezar</name>
<affiliation wicri:level="1"><nlm:affiliation>INSERM U955 Eq16 Faculte de medicine Henri Mondor and Universite Paris-Est, Creteil/Vaccine Research Institute, Creteil 94010, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U955 Eq16 Faculte de medicine Henri Mondor and Universite Paris-Est, Creteil/Vaccine Research Institute, Creteil 94010</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Morris, Melanie" sort="Morris, Melanie" uniqKey="Morris M" first="Melanie" last="Morris">Melanie Morris</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Denyer, Gareth" sort="Denyer, Gareth" uniqKey="Denyer G" first="Gareth" last="Denyer">Gareth Denyer</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Molecular Bioscience, The University of Sydney, Sydney, NSW, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Molecular Bioscience, The University of Sydney, Sydney, NSW</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lee, Sau Kuen" sort="Lee, Sau Kuen" uniqKey="Lee S" first="Sau Kuen" last="Lee">Sau Kuen Lee</name>
<affiliation wicri:level="1"><nlm:affiliation>QIMR Berghofer Centre for Immunotherapy and Vaccine Development QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>QIMR Berghofer Centre for Immunotherapy and Vaccine Development QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Turner, Stephen J" sort="Turner, Stephen J" uniqKey="Turner S" first="Stephen J" last="Turner">Stephen J. Turner</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, Biomedical Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology, Biomedical Discovery Institute, Monash University, Clayton, Victoria 3800</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Seddiki, Nabila" sort="Seddiki, Nabila" uniqKey="Seddiki N" first="Nabila" last="Seddiki">Nabila Seddiki</name>
<affiliation wicri:level="1"><nlm:affiliation>INSERM U955 Eq16 Faculte de medicine Henri Mondor and Universite Paris-Est, Creteil/Vaccine Research Institute, Creteil 94010, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U955 Eq16 Faculte de medicine Henri Mondor and Universite Paris-Est, Creteil/Vaccine Research Institute, Creteil 94010</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Smith, Corey" sort="Smith, Corey" uniqKey="Smith C" first="Corey" last="Smith">Corey Smith</name>
<affiliation wicri:level="1"><nlm:affiliation>QIMR Berghofer Centre for Immunotherapy and Vaccine Development QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>QIMR Berghofer Centre for Immunotherapy and Vaccine Development QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Khanna, Rajiv" sort="Khanna, Rajiv" uniqKey="Khanna R" first="Rajiv" last="Khanna">Rajiv Khanna</name>
<affiliation wicri:level="1"><nlm:affiliation>QIMR Berghofer Centre for Immunotherapy and Vaccine Development QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>QIMR Berghofer Centre for Immunotherapy and Vaccine Development QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rao, Sudha" sort="Rao, Sudha" uniqKey="Rao S" first="Sudha" last="Rao">Sudha Rao</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2017">2017</date>
<idno type="RBID">pubmed:28317936</idno>
<idno type="pmid">28317936</idno>
<idno type="doi">10.1038/srep44825</idno>
<idno type="wicri:Area/PubMed/Corpus">000F98</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000F98</idno>
<idno type="wicri:Area/PubMed/Curation">000F95</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000F95</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Priming of transcriptional memory responses via the chromatin accessibility landscape in T cells.</title>
<author><name sortKey="Tu, Wen Juan" sort="Tu, Wen Juan" uniqKey="Tu W" first="Wen Juan" last="Tu">Wen Juan Tu</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hardy, Kristine" sort="Hardy, Kristine" uniqKey="Hardy K" first="Kristine" last="Hardy">Kristine Hardy</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sutton, Christopher R" sort="Sutton, Christopher R" uniqKey="Sutton C" first="Christopher R" last="Sutton">Christopher R. Sutton</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mccuaig, Robert" sort="Mccuaig, Robert" uniqKey="Mccuaig R" first="Robert" last="Mccuaig">Robert Mccuaig</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Li, Jasmine" sort="Li, Jasmine" uniqKey="Li J" first="Jasmine" last="Li">Jasmine Li</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, Biomedical Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology, Biomedical Discovery Institute, Monash University, Clayton, Victoria 3800</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dunn, Jenny" sort="Dunn, Jenny" uniqKey="Dunn J" first="Jenny" last="Dunn">Jenny Dunn</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tan, Abel" sort="Tan, Abel" uniqKey="Tan A" first="Abel" last="Tan">Abel Tan</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brezar, Vedran" sort="Brezar, Vedran" uniqKey="Brezar V" first="Vedran" last="Brezar">Vedran Brezar</name>
<affiliation wicri:level="1"><nlm:affiliation>INSERM U955 Eq16 Faculte de medicine Henri Mondor and Universite Paris-Est, Creteil/Vaccine Research Institute, Creteil 94010, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U955 Eq16 Faculte de medicine Henri Mondor and Universite Paris-Est, Creteil/Vaccine Research Institute, Creteil 94010</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Morris, Melanie" sort="Morris, Melanie" uniqKey="Morris M" first="Melanie" last="Morris">Melanie Morris</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Denyer, Gareth" sort="Denyer, Gareth" uniqKey="Denyer G" first="Gareth" last="Denyer">Gareth Denyer</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Molecular Bioscience, The University of Sydney, Sydney, NSW, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Molecular Bioscience, The University of Sydney, Sydney, NSW</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lee, Sau Kuen" sort="Lee, Sau Kuen" uniqKey="Lee S" first="Sau Kuen" last="Lee">Sau Kuen Lee</name>
<affiliation wicri:level="1"><nlm:affiliation>QIMR Berghofer Centre for Immunotherapy and Vaccine Development QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>QIMR Berghofer Centre for Immunotherapy and Vaccine Development QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Turner, Stephen J" sort="Turner, Stephen J" uniqKey="Turner S" first="Stephen J" last="Turner">Stephen J. Turner</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, Biomedical Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology, Biomedical Discovery Institute, Monash University, Clayton, Victoria 3800</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Seddiki, Nabila" sort="Seddiki, Nabila" uniqKey="Seddiki N" first="Nabila" last="Seddiki">Nabila Seddiki</name>
<affiliation wicri:level="1"><nlm:affiliation>INSERM U955 Eq16 Faculte de medicine Henri Mondor and Universite Paris-Est, Creteil/Vaccine Research Institute, Creteil 94010, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U955 Eq16 Faculte de medicine Henri Mondor and Universite Paris-Est, Creteil/Vaccine Research Institute, Creteil 94010</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Smith, Corey" sort="Smith, Corey" uniqKey="Smith C" first="Corey" last="Smith">Corey Smith</name>
<affiliation wicri:level="1"><nlm:affiliation>QIMR Berghofer Centre for Immunotherapy and Vaccine Development QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>QIMR Berghofer Centre for Immunotherapy and Vaccine Development QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Khanna, Rajiv" sort="Khanna, Rajiv" uniqKey="Khanna R" first="Rajiv" last="Khanna">Rajiv Khanna</name>
<affiliation wicri:level="1"><nlm:affiliation>QIMR Berghofer Centre for Immunotherapy and Vaccine Development QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>QIMR Berghofer Centre for Immunotherapy and Vaccine Development QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rao, Sudha" sort="Rao, Sudha" uniqKey="Rao S" first="Sudha" last="Rao">Sudha Rao</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Scientific reports</title>
<idno type="eISSN">2045-2322</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Memory T cells exhibit transcriptional memory and "remember" their previous pathogenic encounter to increase transcription on re-infection. However, how this transcriptional priming response is regulated is unknown. Here we performed global FAIRE-seq profiling of chromatin accessibility in a human T cell transcriptional memory model. Primary activation induced persistent accessibility changes, and secondary activation induced secondary-specific opening of previously less accessible regions associated with enhanced expression of memory-responsive genes. Increased accessibility occurred largely in distal regulatory regions and was associated with increased histone acetylation and relative H3.3 deposition. The enhanced re-stimulation response was linked to the strength of initial PKC-induced signalling, and PKC-sensitive increases in accessibility upon initial stimulation showed higher accessibility on re-stimulation. While accessibility maintenance was associated with ETS-1, accessibility at re-stimulation-specific regions was linked to NFAT, especially in combination with ETS-1, EGR, GATA, NFκB, and NR4A. Furthermore, NFATC1 was directly regulated by ETS-1 at an enhancer region. In contrast to the factors that increased accessibility, signalling from bHLH and ZEB family members enhanced decreased accessibility upon re-stimulation. Interplay between distal regulatory elements, accessibility, and the combined action of sequence-specific transcription factors allows transcriptional memory-responsive genes to "remember" their initial environmental encounter.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">28317936</PMID>
<DateCreated><Year>2017</Year>
<Month>03</Month>
<Day>20</Day>
</DateCreated>
<DateRevised><Year>2017</Year>
<Month>03</Month>
<Day>23</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2045-2322</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>7</Volume>
<PubDate><Year>2017</Year>
<Month>Mar</Month>
<Day>20</Day>
</PubDate>
</JournalIssue>
<Title>Scientific reports</Title>
<ISOAbbreviation>Sci Rep</ISOAbbreviation>
</Journal>
<ArticleTitle>Priming of transcriptional memory responses via the chromatin accessibility landscape in T cells.</ArticleTitle>
<Pagination><MedlinePgn>44825</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/srep44825</ELocationID>
<Abstract><AbstractText>Memory T cells exhibit transcriptional memory and "remember" their previous pathogenic encounter to increase transcription on re-infection. However, how this transcriptional priming response is regulated is unknown. Here we performed global FAIRE-seq profiling of chromatin accessibility in a human T cell transcriptional memory model. Primary activation induced persistent accessibility changes, and secondary activation induced secondary-specific opening of previously less accessible regions associated with enhanced expression of memory-responsive genes. Increased accessibility occurred largely in distal regulatory regions and was associated with increased histone acetylation and relative H3.3 deposition. The enhanced re-stimulation response was linked to the strength of initial PKC-induced signalling, and PKC-sensitive increases in accessibility upon initial stimulation showed higher accessibility on re-stimulation. While accessibility maintenance was associated with ETS-1, accessibility at re-stimulation-specific regions was linked to NFAT, especially in combination with ETS-1, EGR, GATA, NFκB, and NR4A. Furthermore, NFATC1 was directly regulated by ETS-1 at an enhancer region. In contrast to the factors that increased accessibility, signalling from bHLH and ZEB family members enhanced decreased accessibility upon re-stimulation. Interplay between distal regulatory elements, accessibility, and the combined action of sequence-specific transcription factors allows transcriptional memory-responsive genes to "remember" their initial environmental encounter.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tu</LastName>
<ForeName>Wen Juan</ForeName>
<Initials>WJ</Initials>
<AffiliationInfo><Affiliation>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hardy</LastName>
<ForeName>Kristine</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sutton</LastName>
<ForeName>Christopher R</ForeName>
<Initials>CR</Initials>
<AffiliationInfo><Affiliation>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McCuaig</LastName>
<ForeName>Robert</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Jasmine</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, Biomedical Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Microbiology &Immunology, The Doherty Institute for Infection and Immunity, University of Melbourne, Victoria 3010, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dunn</LastName>
<ForeName>Jenny</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tan</LastName>
<ForeName>Abel</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Brezar</LastName>
<ForeName>Vedran</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>INSERM U955 Eq16 Faculte de medicine Henri Mondor and Universite Paris-Est, Creteil/Vaccine Research Institute, Creteil 94010, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Morris</LastName>
<ForeName>Melanie</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Denyer</LastName>
<ForeName>Gareth</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>School of Molecular Bioscience, The University of Sydney, Sydney, NSW, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Sau Kuen</ForeName>
<Initials>SK</Initials>
<AffiliationInfo><Affiliation>QIMR Berghofer Centre for Immunotherapy and Vaccine Development QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Tumour Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Turner</LastName>
<ForeName>Stephen J</ForeName>
<Initials>SJ</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, Biomedical Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Microbiology &Immunology, The Doherty Institute for Infection and Immunity, University of Melbourne, Victoria 3010, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Seddiki</LastName>
<ForeName>Nabila</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>INSERM U955 Eq16 Faculte de medicine Henri Mondor and Universite Paris-Est, Creteil/Vaccine Research Institute, Creteil 94010, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Smith</LastName>
<ForeName>Corey</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>QIMR Berghofer Centre for Immunotherapy and Vaccine Development QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Tumour Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Khanna</LastName>
<ForeName>Rajiv</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>QIMR Berghofer Centre for Immunotherapy and Vaccine Development QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Tumour Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rao</LastName>
<ForeName>Sudha</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Faculty of Education, Science, Technology &Mathematics, University of Canberra, Canberra, Australian Capital Territory 2617, Australia.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>03</Month>
<Day>20</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Sci Rep</MedlineTA>
<NlmUniqueID>101563288</NlmUniqueID>
<ISSNLinking>2045-2322</ISSNLinking>
</MedlineJournalInfo>
<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Cell Sci. 2016 Jun 15;129(12):2448-61</RefSource>
<PMID Version="1">27149922</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Immunity. 2014 Nov 20;41(5):853-65</RefSource>
<PMID Version="1">25517617</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cell. 2013 Jan 17;152(1-2):157-71</RefSource>
<PMID Version="1">23332752</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Protoc. 2007;2(7):1722-33</RefSource>
<PMID Version="1">17641637</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50</RefSource>
<PMID Version="1">16199517</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15776-81</RefSource>
<PMID Version="1">24019486</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Genes Dev. 2003 Sep 15;17(18):2205-32</RefSource>
<PMID Version="1">12975316</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 2013 Nov 14;503(7475):290-4</RefSource>
<PMID Version="1">24141950</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mol Cell. 2011 Mar 18;41(6):704-19</RefSource>
<PMID Version="1">21419345</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mol Cell Biol. 2009 Apr;29(7):1972-86</RefSource>
<PMID Version="1">19158270</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Curr Protoc Mol Biol. 2013;Chapter 21:Unit21.26</RefSource>
<PMID Version="1">23547014</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Methods. 2012 Mar 04;9(4):357-9</RefSource>
<PMID Version="1">22388286</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nucleic Acids Res. 2008 Sep;36(15):4845-62</RefSource>
<PMID Version="1">18653526</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mol Cell Biol. 2015 Oct 19;36(1):119-31</RefSource>
<PMID Version="1">26483414</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2001 Jun 15;166(12):7335-44</RefSource>
<PMID Version="1">11390484</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Biotechnol. 2010 Oct;28(10):1045-8</RefSource>
<PMID Version="1">20944595</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Genes Dev. 2014 Apr 1;28(7):672-82</RefSource>
<PMID Version="1">24696452</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Annu Rev Genet. 2015;49:627-46</RefSource>
<PMID Version="1">26436457</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Blood. 2010 Nov 11;116(19):3899-906</RefSource>
<PMID Version="1">20664054</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Genome Res. 2013 Jul;23(7):1130-41</RefSource>
<PMID Version="1">23570689</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2012 Oct;18(10):1518-24</RefSource>
<PMID Version="1">23023500</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 2014 Aug 7;512(7512):96-100</RefSource>
<PMID Version="1">25043061</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2013 Dec 15;191(12):5797-801</RefSource>
<PMID Version="1">24244018</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Immunol. 2014 Aug;15(8):777-88</RefSource>
<PMID Version="1">24997565</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2011 Jul 1;187(1):133-40</RefSource>
<PMID Version="1">21642544</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Genes Dev. 2013 Oct 1;27(19):2109-24</RefSource>
<PMID Version="1">24065740</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Front Immunol. 2014 Feb 03;5:21</RefSource>
<PMID Version="1">24550910</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2003 Jun 1;170(11):5455-63</RefSource>
<PMID Version="1">12759421</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Genome Biol. 2009;10(10):R107</RefSource>
<PMID Version="1">19807913</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Blood. 2010 Apr 15;115(15):2989-97</RefSource>
<PMID Version="1">20103781</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Pharmacol Exp Ther. 2009 Sep;330(3):792-801</RefSource>
<PMID Version="1">19491325</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Immunity. 2015 Feb 17;42(2):265-78</RefSource>
<PMID Version="1">25680272</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2014 Jun 19;9(6):e99989</RefSource>
<PMID Version="1">24945803</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mol Cell Biol. 2004 Sep;24(18):7914-30</RefSource>
<PMID Version="1">15340054</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mol Cell. 2010 May 28;38(4):576-89</RefSource>
<PMID Version="1">20513432</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Front Immunol. 2015 Dec 10;6:617</RefSource>
<PMID Version="1">26697013</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 1998 Jun 15;187(12):2031-6</RefSource>
<PMID Version="1">9625762</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Genome Biol. 2008;9(9):R137</RefSource>
<PMID Version="1">18798982</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>EMBO J. 2016 Mar 1;35(5):515-35</RefSource>
<PMID Version="1">26796577</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7175-80</RefSource>
<PMID Version="1">17438271</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nucleic Acids Res. 2007 Jul;35(Web Server issue):W169-75</RefSource>
<PMID Version="1">17576678</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2011 Nov 15;187(10 ):5233-45</RefSource>
<PMID Version="1">22013130</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mol Cell. 2013 Feb 7;49(3):524-35</RefSource>
<PMID Version="1">23273978</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mol Cell Biol. 1998 Apr;18(4):2218-29</RefSource>
<PMID Version="1">9528793</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Rev Immunol. 2012 Mar 16;12(4):306-15</RefSource>
<PMID Version="1">22421787</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mol Cell Biol. 2000 Apr;20(8):2933-40</RefSource>
<PMID Version="1">10733597</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Methods. 2012 Jun 28;9(7):676-82</RefSource>
<PMID Version="1">22743772</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Transcription. 2011 Jul;2(4):189-192</RefSource>
<PMID Version="1">21922062</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Scand J Immunol. 1991 Apr;33(4):393-403</RefSource>
<PMID Version="1">2017664</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Trends Genet. 2016 Jan;32(1):42-56</RefSource>
<PMID Version="1">26704082</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16850-5</RefSource>
<PMID Version="1">17940009</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Med Chem. 2013 Mar 14;56(5):1799-810</RefSource>
<PMID Version="1">23398373</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2011 Mar 1;186(5):2705-9</RefSource>
<PMID Version="1">21278341</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2007 Sep 15;179(6):3689-98</RefSource>
<PMID Version="1">17785805</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Annu Rev Immunol. 2016 May 20;34:511-38</RefSource>
<PMID Version="1">27168244</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nucleic Acids Res. 2004 Feb 26;32(4):1372-81</RefSource>
<PMID Version="1">14988425</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Trends Immunol. 2006 Oct;27(10):461-9</RefSource>
<PMID Version="1">16931157</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Sci Rep. 2016 Dec 05;6:38411</RefSource>
<PMID Version="1">27917918</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cell. 2011 Nov 23;147(5):1132-45</RefSource>
<PMID Version="1">22118467</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Blood. 2014 Apr 24;123(17):e68-78</RefSource>
<PMID Version="1">24671953</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Genes Dev. 2016 Jun 15;30(12):1357-82</RefSource>
<PMID Version="1">27340173</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 2003 Feb 17;197(4):413-23</RefSource>
<PMID Version="1">12591900</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2016 Sep 15;197(6):2465-72</RefSource>
<PMID Version="1">27496971</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Cell Physiol. 1988 Nov;137(2):329-36</RefSource>
<PMID Version="1">3263971</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nucleus. 2016;7(1):50-67</RefSource>
<PMID Version="1">26962893</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>BMC Genomics. 2014 May 02;15:331</RefSource>
<PMID Version="1">24885402</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Immunity. 2009 Jun 19;30(6):912-25</RefSource>
<PMID Version="1">19523850</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 1996 Jan 12;271(2):774-82</RefSource>
<PMID Version="1">8557686</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Methods. 2012 Nov;58(3):255-67</RefSource>
<PMID Version="1">23137922</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS Genet. 2011 Oct;7(10):e1002311</RefSource>
<PMID Version="1">22028663</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cell. 2012 Sep 28;151(1):153-66</RefSource>
<PMID Version="1">23021222</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year>
<Month>11</Month>
<Day>28</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2017</Year>
<Month>02</Month>
<Day>14</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
<Month>3</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
<Month>3</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2017</Year>
<Month>3</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>epublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">28317936</ArticleId>
<ArticleId IdType="pii">srep44825</ArticleId>
<ArticleId IdType="doi">10.1038/srep44825</ArticleId>
<ArticleId IdType="pmc">PMC5357947</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F95 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 000F95 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= PubMed |étape= Curation |type= RBID |clé= pubmed:28317936 |texte= Priming of transcriptional memory responses via the chromatin accessibility landscape in T cells. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:28317936" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
This area was generated with Dilib version V0.6.33. |