Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.
Identifieur interne : 002209 ( PubMed/Corpus ); précédent : 002208; suivant : 002210Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.
Auteurs : Alexander Teumer ; Adrienne Tin ; Rossella Sorice ; Mathias Gorski ; Nan Cher Yeo ; Audrey Y. Chu ; Man Li ; Yong Li ; Vladan Mijatovic ; Yi-An Ko ; Daniel Taliun ; Alessandro Luciani ; Ming-Huei Chen ; Qiong Yang ; Meredith C. Foster ; Matthias Olden ; Linda T. Hiraki ; Bamidele O. Tayo ; Christian Fuchsberger ; Aida Karina Dieffenbach ; Alan R. Shuldiner ; Albert V. Smith ; Allison M. Zappa ; Antonio Lupo ; Barbara Kollerits ; Belen Ponte ; Bénédicte Stengel ; Bernhard K. Kr Mer ; Bernhard Paulweber ; Braxton D. Mitchell ; Caroline Hayward ; Catherine Helmer ; Christa Meisinger ; Christian Gieger ; Christian M. Shaffer ; Christian Müller ; Claudia Langenberg ; Daniel Ackermann ; David Siscovick ; Eric Boerwinkle ; Florian Kronenberg ; Georg B. Ehret ; Georg Homuth ; Gerard Waeber ; Gerjan Navis ; Giovanni Gambaro ; Giovanni Malerba ; Gudny Eiriksdottir ; Guo Li ; H Erich Wichmann ; Harald Grallert ; Henri Wallaschofski ; Henry Völzke ; Herrmann Brenner ; Holly Kramer ; I. Mateo Leach ; Igor Rudan ; Hans L. Hillege ; Jacques S. Beckmann ; Jean Charles Lambert ; Jian'An Luan ; Jing Hua Zhao ; John Chalmers ; Josef Coresh ; Joshua C. Denny ; Katja Butterbach ; Lenore J. Launer ; Luigi Ferrucci ; Lyudmyla Kedenko ; Margot Haun ; Marie Metzger ; Mark Woodward ; Matthew J. Hoffman ; Matthias Nauck ; Melanie Waldenberger ; Menno Pruijm ; Murielle Bochud ; Myriam Rheinberger ; Niek Verweij ; Nicholas J. Wareham ; Nicole Endlich ; Nicole Soranzo ; Ozren Polasek ; Pim Van Der Harst ; Peter Paul Pramstaller ; Peter Vollenweider ; Philipp S. Wild ; Ron T. Gansevoort ; Rainer Rettig ; Reiner Biffar ; Robert J. Carroll ; Ronit Katz ; Ruth J F. Loos ; Shih-Jen Hwang ; Stefan Coassin ; Sven Bergmann ; Sylvia E. Rosas ; Sylvia Stracke ; Tamara B. Harris ; Tanguy Corre ; Tanja Zeller ; Thomas Illig ; Thor Aspelund ; Toshiko Tanaka ; Uwe Lendeckel ; Uwe Völker ; Vilmundur Gudnason ; Vincent Chouraki ; Wolfgang Koenig ; Zoltan Kutalik ; Jeffrey R. O'Connell ; Afshin Parsa ; Iris M. Heid ; Andrew D. Paterson ; Ian H. De Boer ; Olivier Devuyst ; Jozef Lazar ; Karlhans Endlich ; Katalin Susztak ; Johanne Tremblay ; Pavel Hamet ; Howard J. Jacob ; Carsten A. Böger ; Caroline S. Fox ; Cristian Pattaro ; Anna KöttgenSource :
- Diabetes [ 1939-327X ] ; 2016.
English descriptors
- KwdEn :
- Adult, Aged, Albuminuria (etiology), Albuminuria (genetics), Animals, Cathepsin C (genetics), Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 2 (complications), Diabetes Mellitus, Type 2 (genetics), Diabetic Nephropathies (etiology), Diabetic Nephropathies (genetics), Female, Gene Knockout Techniques, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Kidney (metabolism), Kidney Tubules (metabolism), Male, Middle Aged, Polymorphism, Single Nucleotide, Rats, Receptors, Cell Surface (genetics), Sulfotransferases (genetics), rab GTP-Binding Proteins (genetics), rab GTP-Binding Proteins (metabolism).
- MESH :
- chemical , genetics : Cathepsin C, Receptors, Cell Surface, Sulfotransferases, rab GTP-Binding Proteins.
- complications : Diabetes Mellitus, Type 2.
- etiology : Albuminuria, Diabetic Nephropathies.
- genetics : Albuminuria, Diabetes Mellitus, Type 2, Diabetic Nephropathies.
- metabolism : Kidney, Kidney Tubules, rab GTP-Binding Proteins.
- Adult, Aged, Animals, Diabetes Mellitus, Experimental, Female, Gene Knockout Techniques, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Rats.
Abstract
Elevated concentrations of albumin in the urine, albuminuria, are a hallmark of diabetic kidney disease and are associated with an increased risk for end-stage renal disease and cardiovascular events. To gain insight into the pathophysiological mechanisms underlying albuminuria, we conducted meta-analyses of genome-wide association studies and independent replication in up to 5,825 individuals of European ancestry with diabetes and up to 46,061 without diabetes, followed by functional studies. Known associations of variants in CUBN, encoding cubilin, with the urinary albumin-to-creatinine ratio (UACR) were confirmed in the overall sample (P = 2.4 × 10(-10)). Gene-by-diabetes interactions were detected and confirmed for variants in HS6ST1 and near RAB38/CTSC. Single nucleotide polymorphisms at these loci demonstrated a genetic effect on UACR in individuals with but not without diabetes. The change in the average UACR per minor allele was 21% for HS6ST1 (P = 6.3 × 10(-7)) and 13% for RAB38/CTSC (P = 5.8 × 10(-7)). Experiments using streptozotocin-induced diabetic Rab38 knockout and control rats showed higher urinary albumin concentrations and reduced amounts of megalin and cubilin at the proximal tubule cell surface in Rab38 knockout versus control rats. Relative expression of RAB38 was higher in tubuli of patients with diabetic kidney disease compared with control subjects. The loci identified here confirm known pathways and highlight novel pathways influencing albuminuria.
DOI: 10.2337/db15-1313
PubMed: 26631737
Links to Exploration step
pubmed:26631737Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.</title><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation><nlm:affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany German Center for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany anna.koettgen@uniklinik-freiburg.de ateumer@uni-greifswald.de foxca@nhlbi.nih.gov cristian.pattaro@eurac.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Tin, Adrienne" sort="Tin, Adrienne" uniqKey="Tin A" first="Adrienne" last="Tin">Adrienne Tin</name><affiliation><nlm:affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.</nlm:affiliation></affiliation></author><author><name sortKey="Sorice, Rossella" sort="Sorice, Rossella" uniqKey="Sorice R" first="Rossella" last="Sorice">Rossella Sorice</name><affiliation><nlm:affiliation>Institute of Genetics and Biophysics, "Adriano-Buzzati Traverso," Consiglio Nazionale delle Ricerche, Naples, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Gorski, Mathias" sort="Gorski, Mathias" uniqKey="Gorski M" first="Mathias" last="Gorski">Mathias Gorski</name><affiliation><nlm:affiliation>Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Yeo, Nan Cher" sort="Yeo, Nan Cher" uniqKey="Yeo N" first="Nan Cher" last="Yeo">Nan Cher Yeo</name><affiliation><nlm:affiliation>Department of Physiology, Medical College of Wisconsin, Milwaukee, WI.</nlm:affiliation></affiliation></author><author><name sortKey="Chu, Audrey Y" sort="Chu, Audrey Y" uniqKey="Chu A" first="Audrey Y" last="Chu">Audrey Y. Chu</name><affiliation><nlm:affiliation>Preventive Medicine, Brigham and Women's Hospital, Boston, MA National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, MA.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Man" sort="Li, Man" uniqKey="Li M" first="Man" last="Li">Man Li</name><affiliation><nlm:affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Yong" sort="Li, Yong" uniqKey="Li Y" first="Yong" last="Li">Yong Li</name><affiliation><nlm:affiliation>Renal Division, Medical Center, University of Freiburg, Freiburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Mijatovic, Vladan" sort="Mijatovic, Vladan" uniqKey="Mijatovic V" first="Vladan" last="Mijatovic">Vladan Mijatovic</name><affiliation><nlm:affiliation>Department of Life and Reproduction Sciences, University of Verona, Verona, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Ko, Yi An" sort="Ko, Yi An" uniqKey="Ko Y" first="Yi-An" last="Ko">Yi-An Ko</name><affiliation><nlm:affiliation>Renal-Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, PA.</nlm:affiliation></affiliation></author><author><name sortKey="Taliun, Daniel" sort="Taliun, Daniel" uniqKey="Taliun D" first="Daniel" last="Taliun">Daniel Taliun</name><affiliation><nlm:affiliation>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck, Bolzano, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Luciani, Alessandro" sort="Luciani, Alessandro" uniqKey="Luciani A" first="Alessandro" last="Luciani">Alessandro Luciani</name><affiliation><nlm:affiliation>Institute of Physiology, Mechanisms of Inherited Kidney Disorders Group, University of Zürich, Zürich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Ming Huei" sort="Chen, Ming Huei" uniqKey="Chen M" first="Ming-Huei" last="Chen">Ming-Huei Chen</name><affiliation><nlm:affiliation>Department of Neurology, Boston University School of Medicine, Boston, MA Department of Biostatistics, Boston University School of Public Health, Boston, MA.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name><affiliation><nlm:affiliation>Department of Biostatistics, Boston University School of Public Health, Boston, MA.</nlm:affiliation></affiliation></author><author><name sortKey="Foster, Meredith C" sort="Foster, Meredith C" uniqKey="Foster M" first="Meredith C" last="Foster">Meredith C. Foster</name><affiliation><nlm:affiliation>Tufts Medical Center, Boston, MA.</nlm:affiliation></affiliation></author><author><name sortKey="Olden, Matthias" sort="Olden, Matthias" uniqKey="Olden M" first="Matthias" last="Olden">Matthias Olden</name><affiliation><nlm:affiliation>Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany Department of Epidemiology and Preventive Medicine, Regensburg University Medical Center, Regensburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hiraki, Linda T" sort="Hiraki, Linda T" uniqKey="Hiraki L" first="Linda T" last="Hiraki">Linda T. Hiraki</name><affiliation><nlm:affiliation>Genetics and Genome Biology Program, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Tayo, Bamidele O" sort="Tayo, Bamidele O" uniqKey="Tayo B" first="Bamidele O" last="Tayo">Bamidele O. Tayo</name><affiliation><nlm:affiliation>Loyola University Chicago, Maywood, IL.</nlm:affiliation></affiliation></author><author><name sortKey="Fuchsberger, Christian" sort="Fuchsberger, Christian" uniqKey="Fuchsberger C" first="Christian" last="Fuchsberger">Christian Fuchsberger</name><affiliation><nlm:affiliation>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck, Bolzano, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Dieffenbach, Aida Karina" sort="Dieffenbach, Aida Karina" uniqKey="Dieffenbach A" first="Aida Karina" last="Dieffenbach">Aida Karina Dieffenbach</name><affiliation><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany German Cancer Consortium (DKTK), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R" last="Shuldiner">Alan R. Shuldiner</name><affiliation><nlm:affiliation>Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V" last="Smith">Albert V. Smith</name><affiliation><nlm:affiliation>Icelandic Heart Association, Kópavogur, Iceland Faculty of Medicine, University of Iceland, Reykjavik, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Zappa, Allison M" sort="Zappa, Allison M" uniqKey="Zappa A" first="Allison M" last="Zappa">Allison M. Zappa</name><affiliation><nlm:affiliation>Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI.</nlm:affiliation></affiliation></author><author><name sortKey="Lupo, Antonio" sort="Lupo, Antonio" uniqKey="Lupo A" first="Antonio" last="Lupo">Antonio Lupo</name><affiliation><nlm:affiliation>Renal Unit, Department of Medicine, University of Verona, Verona, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Kollerits, Barbara" sort="Kollerits, Barbara" uniqKey="Kollerits B" first="Barbara" last="Kollerits">Barbara Kollerits</name><affiliation><nlm:affiliation>Division of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Ponte, Belen" sort="Ponte, Belen" uniqKey="Ponte B" first="Belen" last="Ponte">Belen Ponte</name><affiliation><nlm:affiliation>Nephrology Division, Department of Specialties of Internal Medicine, Geneva University Hospitals, Geneva, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Stengel, Benedicte" sort="Stengel, Benedicte" uniqKey="Stengel B" first="Bénédicte" last="Stengel">Bénédicte Stengel</name><affiliation><nlm:affiliation>INSERM U-1018, Centre de recherche en épidémiologie et santé des populations (CESP) Team 5, Villejuif, France UMRS 1018, Centre de recherche en épidémiologie et santé des populations (CESP) Team 5, Univ Paris Sud, Univ Versailles, St. Quentin, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kr Mer, Bernhard K" sort="Kr Mer, Bernhard K" uniqKey="Kr Mer B" first="Bernhard K" last="Kr Mer">Bernhard K. Kr Mer</name><affiliation><nlm:affiliation>Fifth Department of Medicine, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Paulweber, Bernhard" sort="Paulweber, Bernhard" uniqKey="Paulweber B" first="Bernhard" last="Paulweber">Bernhard Paulweber</name><affiliation><nlm:affiliation>First Department of Internal Medicine, Paracelsus Medical University/Salzburger Landeskliniken, Salzburg, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D" last="Mitchell">Braxton D. Mitchell</name><affiliation><nlm:affiliation>Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.</nlm:affiliation></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation><nlm:affiliation>Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, U.K.</nlm:affiliation></affiliation></author><author><name sortKey="Helmer, Catherine" sort="Helmer, Catherine" uniqKey="Helmer C" first="Catherine" last="Helmer">Catherine Helmer</name><affiliation><nlm:affiliation>INSERM U897, Bordeaux University, Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Meisinger, Christa" sort="Meisinger, Christa" uniqKey="Meisinger C" first="Christa" last="Meisinger">Christa Meisinger</name><affiliation><nlm:affiliation>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation><nlm:affiliation>Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Shaffer, Christian M" sort="Shaffer, Christian M" uniqKey="Shaffer C" first="Christian M" last="Shaffer">Christian M. Shaffer</name><affiliation><nlm:affiliation>Vanderbilt University School of Medicine, Nashville, TN.</nlm:affiliation></affiliation></author><author><name sortKey="Muller, Christian" sort="Muller, Christian" uniqKey="Muller C" first="Christian" last="Müller">Christian Müller</name><affiliation><nlm:affiliation>University Heart Center Hamburg, Hamburg, Germany German Center for Cardiovascular Research (DZHK e.V.), partner site Hamburg, Lübeck, Kiel, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation><nlm:affiliation>Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, U.K.</nlm:affiliation></affiliation></author><author><name sortKey="Ackermann, Daniel" sort="Ackermann, Daniel" uniqKey="Ackermann D" first="Daniel" last="Ackermann">Daniel Ackermann</name><affiliation><nlm:affiliation>University Clinic for Nephrology, Hypertension and Clinical Pharmacology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Siscovick, David" sort="Siscovick, David" uniqKey="Siscovick D" first="David" last="Siscovick">David Siscovick</name><affiliation><nlm:affiliation>Cardiovascular Health Research Unit, Departments of Epidemiology and Medicine, University of Washington, Seattle, WA.</nlm:affiliation></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation><nlm:affiliation>Human Genetics Center, University of Texas Health Science Center, Houston, TX.</nlm:affiliation></affiliation></author><author><name sortKey="Kronenberg, Florian" sort="Kronenberg, Florian" uniqKey="Kronenberg F" first="Florian" last="Kronenberg">Florian Kronenberg</name><affiliation><nlm:affiliation>Division of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Ehret, Georg B" sort="Ehret, Georg B" uniqKey="Ehret G" first="Georg B" last="Ehret">Georg B. Ehret</name><affiliation><nlm:affiliation>Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospitals, Geneva, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name><affiliation><nlm:affiliation>Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Waeber, Gerard" sort="Waeber, Gerard" uniqKey="Waeber G" first="Gerard" last="Waeber">Gerard Waeber</name><affiliation><nlm:affiliation>Department of Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Navis, Gerjan" sort="Navis, Gerjan" uniqKey="Navis G" first="Gerjan" last="Navis">Gerjan Navis</name><affiliation><nlm:affiliation>Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Gambaro, Giovanni" sort="Gambaro, Giovanni" uniqKey="Gambaro G" first="Giovanni" last="Gambaro">Giovanni Gambaro</name><affiliation><nlm:affiliation>Division of Nephrology, Department of Internal Medicine and Medical Specialties, Columbus-Gemelli University Hospital, Catholic University, Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Malerba, Giovanni" sort="Malerba, Giovanni" uniqKey="Malerba G" first="Giovanni" last="Malerba">Giovanni Malerba</name><affiliation><nlm:affiliation>Department of Life and Reproduction Sciences, University of Verona, Verona, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation><nlm:affiliation>Icelandic Heart Association, Kópavogur, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Guo" sort="Li, Guo" uniqKey="Li G" first="Guo" last="Li">Guo Li</name><affiliation><nlm:affiliation>Cardiovascular Health Research Unit, Departments of Epidemiology and Medicine, University of Washington, Seattle, WA.</nlm:affiliation></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H Erich" last="Wichmann">H Erich Wichmann</name><affiliation><nlm:affiliation>Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany Institute of Medical Statistics and Epidemiology, Technical University Munich, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Grallert, Harald" sort="Grallert, Harald" uniqKey="Grallert H" first="Harald" last="Grallert">Harald Grallert</name><affiliation><nlm:affiliation>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany German Center for Diabetes Research (DZD), Neuherberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Wallaschofski, Henri" sort="Wallaschofski, Henri" uniqKey="Wallaschofski H" first="Henri" last="Wallaschofski">Henri Wallaschofski</name><affiliation><nlm:affiliation>Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation><nlm:affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany German Center for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Brenner, Herrmann" sort="Brenner, Herrmann" uniqKey="Brenner H" first="Herrmann" last="Brenner">Herrmann Brenner</name><affiliation><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kramer, Holly" sort="Kramer, Holly" uniqKey="Kramer H" first="Holly" last="Kramer">Holly Kramer</name><affiliation><nlm:affiliation>Loyola University Chicago, Maywood, IL.</nlm:affiliation></affiliation></author><author><name sortKey="Mateo Leach, I" sort="Mateo Leach, I" uniqKey="Mateo Leach I" first="I" last="Mateo Leach">I. Mateo Leach</name><affiliation><nlm:affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation><nlm:affiliation>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, Scotland, U.K.</nlm:affiliation></affiliation></author><author><name sortKey="Hillege, Hans L" sort="Hillege, Hans L" uniqKey="Hillege H" first="Hans L" last="Hillege">Hans L. Hillege</name><affiliation><nlm:affiliation>Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Beckmann, Jacques S" sort="Beckmann, Jacques S" uniqKey="Beckmann J" first="Jacques S" last="Beckmann">Jacques S. Beckmann</name><affiliation><nlm:affiliation>Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland Swiss Institute of Bioinformatics, Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean Charles" last="Lambert">Jean Charles Lambert</name><affiliation><nlm:affiliation>INSERM UMR 1167 "Risk factors and molecular determinants of aging-related diseases," Institut Pasteur de Lille, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Luan, Jian An" sort="Luan, Jian An" uniqKey="Luan J" first="Jian'An" last="Luan">Jian'An Luan</name><affiliation><nlm:affiliation>Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, U.K.</nlm:affiliation></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:affiliation>Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, U.K.</nlm:affiliation></affiliation></author><author><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name><affiliation><nlm:affiliation>The George Institute for Global Health, University of Sydney, Camperdown, New South Wales, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Coresh, Josef" sort="Coresh, Josef" uniqKey="Coresh J" first="Josef" last="Coresh">Josef Coresh</name><affiliation><nlm:affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Welch Center for Prevention, Epidemiology and Clinical Research, Baltimore, MD.</nlm:affiliation></affiliation></author><author><name sortKey="Denny, Joshua C" sort="Denny, Joshua C" uniqKey="Denny J" first="Joshua C" last="Denny">Joshua C. Denny</name><affiliation><nlm:affiliation>Vanderbilt University School of Medicine, Nashville, TN.</nlm:affiliation></affiliation></author><author><name sortKey="Butterbach, Katja" sort="Butterbach, Katja" uniqKey="Butterbach K" first="Katja" last="Butterbach">Katja Butterbach</name><affiliation><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name><affiliation><nlm:affiliation>Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD.</nlm:affiliation></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation><nlm:affiliation>Clinical Research Branch, National Institute on Aging, Baltimore, MD.</nlm:affiliation></affiliation></author><author><name sortKey="Kedenko, Lyudmyla" sort="Kedenko, Lyudmyla" uniqKey="Kedenko L" first="Lyudmyla" last="Kedenko">Lyudmyla Kedenko</name><affiliation><nlm:affiliation>First Department of Internal Medicine, Paracelsus Medical University/Salzburger Landeskliniken, Salzburg, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Haun, Margot" sort="Haun, Margot" uniqKey="Haun M" first="Margot" last="Haun">Margot Haun</name><affiliation><nlm:affiliation>Division of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Metzger, Marie" sort="Metzger, Marie" uniqKey="Metzger M" first="Marie" last="Metzger">Marie Metzger</name><affiliation><nlm:affiliation>INSERM U-1018, Centre de recherche en épidémiologie et santé des populations (CESP) Team 5, Villejuif, France UMRS 1018, Centre de recherche en épidémiologie et santé des populations (CESP) Team 5, Univ Paris Sud, Univ Versailles, St. Quentin, France.</nlm:affiliation></affiliation></author><author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name><affiliation><nlm:affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD The George Institute for Global Health, University of Sydney, Camperdown, New South Wales, Australia The George Institute for Global Health, Nuffield Department of Population Health, University of Oxford, Oxford, U.K.</nlm:affiliation></affiliation></author><author><name sortKey="Hoffman, Matthew J" sort="Hoffman, Matthew J" uniqKey="Hoffman M" first="Matthew J" last="Hoffman">Matthew J. Hoffman</name><affiliation><nlm:affiliation>Department of Physiology, Medical College of Wisconsin, Milwaukee, WI.</nlm:affiliation></affiliation></author><author><name sortKey="Nauck, Matthias" sort="Nauck, Matthias" uniqKey="Nauck M" first="Matthias" last="Nauck">Matthias Nauck</name><affiliation><nlm:affiliation>German Center for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Waldenberger, Melanie" sort="Waldenberger, Melanie" uniqKey="Waldenberger M" first="Melanie" last="Waldenberger">Melanie Waldenberger</name><affiliation><nlm:affiliation>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Pruijm, Menno" sort="Pruijm, Menno" uniqKey="Pruijm M" first="Menno" last="Pruijm">Menno Pruijm</name><affiliation><nlm:affiliation>Service of Nephrology, Lausanne University Hospital, Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Bochud, Murielle" sort="Bochud, Murielle" uniqKey="Bochud M" first="Murielle" last="Bochud">Murielle Bochud</name><affiliation><nlm:affiliation>University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Épalinges, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Rheinberger, Myriam" sort="Rheinberger, Myriam" uniqKey="Rheinberger M" first="Myriam" last="Rheinberger">Myriam Rheinberger</name><affiliation><nlm:affiliation>Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Verweij, Niek" sort="Verweij, Niek" uniqKey="Verweij N" first="Niek" last="Verweij">Niek Verweij</name><affiliation><nlm:affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:affiliation>Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, U.K.</nlm:affiliation></affiliation></author><author><name sortKey="Endlich, Nicole" sort="Endlich, Nicole" uniqKey="Endlich N" first="Nicole" last="Endlich">Nicole Endlich</name><affiliation><nlm:affiliation>Institute of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation><nlm:affiliation>Human Genetics, Wellcome Trust Sanger Institute, Hinxton, U.K. Department of Haematology, University of Cambridge, Cambridge, U.K.</nlm:affiliation></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation><nlm:affiliation>Croatian Centre for Global Health, Faculty of Medicine, University of Split, Split, Croatia.</nlm:affiliation></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation><nlm:affiliation>Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Pramstaller, Peter Paul" sort="Pramstaller, Peter Paul" uniqKey="Pramstaller P" first="Peter Paul" last="Pramstaller">Peter Paul Pramstaller</name><affiliation><nlm:affiliation>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck, Bolzano, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation><nlm:affiliation>Department of Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Wild, Philipp S" sort="Wild, Philipp S" uniqKey="Wild P" first="Philipp S" last="Wild">Philipp S. Wild</name><affiliation><nlm:affiliation>Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg, University Mainz, Mainz, Germany Preventive Cardiology and Preventive Medicine, Department of Medicine 2, University Medical Center of the Johannes Gutenberg, University Mainz, Mainz, Germany German Center for Cardiovascular Research (DZHK), Mainz, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Gansevoort, Ron T" sort="Gansevoort, Ron T" uniqKey="Gansevoort R" first="Ron T" last="Gansevoort">Ron T. Gansevoort</name><affiliation><nlm:affiliation>Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Rettig, Rainer" sort="Rettig, Rainer" uniqKey="Rettig R" first="Rainer" last="Rettig">Rainer Rettig</name><affiliation><nlm:affiliation>Institute of Physiology, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Biffar, Reiner" sort="Biffar, Reiner" uniqKey="Biffar R" first="Reiner" last="Biffar">Reiner Biffar</name><affiliation><nlm:affiliation>Clinic for Prosthetic Dentistry, Gerostomatology and Material Science, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Carroll, Robert J" sort="Carroll, Robert J" uniqKey="Carroll R" first="Robert J" last="Carroll">Robert J. Carroll</name><affiliation><nlm:affiliation>Vanderbilt University School of Medicine, Nashville, TN.</nlm:affiliation></affiliation></author><author><name sortKey="Katz, Ronit" sort="Katz, Ronit" uniqKey="Katz R" first="Ronit" last="Katz">Ronit Katz</name><affiliation><nlm:affiliation>Kidney Research Institute, Department of Medicine, University of Washington, Seattle, WA.</nlm:affiliation></affiliation></author><author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J F" last="Loos">Ruth J F. Loos</name><affiliation><nlm:affiliation>Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, U.K. Genetics of Obesity and Related Metabolic Traits Program, The Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Hwang, Shih Jen" sort="Hwang, Shih Jen" uniqKey="Hwang S" first="Shih-Jen" last="Hwang">Shih-Jen Hwang</name><affiliation><nlm:affiliation>National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, MA.</nlm:affiliation></affiliation></author><author><name sortKey="Coassin, Stefan" sort="Coassin, Stefan" uniqKey="Coassin S" first="Stefan" last="Coassin">Stefan Coassin</name><affiliation><nlm:affiliation>Division of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Bergmann, Sven" sort="Bergmann, Sven" uniqKey="Bergmann S" first="Sven" last="Bergmann">Sven Bergmann</name><affiliation><nlm:affiliation>Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Rosas, Sylvia E" sort="Rosas, Sylvia E" uniqKey="Rosas S" first="Sylvia E" last="Rosas">Sylvia E. Rosas</name><affiliation><nlm:affiliation>Kidney and Hypertension Section, Joslin Diabetes Center and Harvard Medical School, Boston, MA.</nlm:affiliation></affiliation></author><author><name sortKey="Stracke, Sylvia" sort="Stracke, Sylvia" uniqKey="Stracke S" first="Sylvia" last="Stracke">Sylvia Stracke</name><affiliation><nlm:affiliation>Clinic for Internal Medicine A, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B" last="Harris">Tamara B. Harris</name><affiliation><nlm:affiliation>Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD.</nlm:affiliation></affiliation></author><author><name sortKey="Corre, Tanguy" sort="Corre, Tanguy" uniqKey="Corre T" first="Tanguy" last="Corre">Tanguy Corre</name><affiliation><nlm:affiliation>Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Zeller, Tanja" sort="Zeller, Tanja" uniqKey="Zeller T" first="Tanja" last="Zeller">Tanja Zeller</name><affiliation><nlm:affiliation>University Heart Center Hamburg, Hamburg, Germany German Center for Cardiovascular Research (DZHK e.V.), partner site Hamburg, Lübeck, Kiel, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><affiliation><nlm:affiliation>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany Institute for Human Genetics, Hannover Medical School, Hannover, Germany Hannover Unified Biobank, Hannover Medical School, Hannover, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Aspelund, Thor" sort="Aspelund, Thor" uniqKey="Aspelund T" first="Thor" last="Aspelund">Thor Aspelund</name><affiliation><nlm:affiliation>Icelandic Heart Association, Kópavogur, Iceland Faculty of Medicine, University of Iceland, Reykjavik, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name><affiliation><nlm:affiliation>Clinical Research Branch, National Institute on Aging, Baltimore, MD.</nlm:affiliation></affiliation></author><author><name sortKey="Lendeckel, Uwe" sort="Lendeckel, Uwe" uniqKey="Lendeckel U" first="Uwe" last="Lendeckel">Uwe Lendeckel</name><affiliation><nlm:affiliation>Institute of Medical Biochemistry and Molecular Biology, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><affiliation><nlm:affiliation>German Center for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:affiliation>Icelandic Heart Association, Kópavogur, Iceland Faculty of Medicine, University of Iceland, Reykjavik, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name><affiliation><nlm:affiliation>INSERM UMR 1167 "Risk factors and molecular determinants of aging-related diseases," Institut Pasteur de Lille, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name><affiliation><nlm:affiliation>Abteilung Innere II, Universitätsklinikum Ulm, Ulm, Germany Deutsches Herzzentrum München, Technische Universität München, Munich, Germany German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltan" last="Kutalik">Zoltan Kutalik</name><affiliation><nlm:affiliation>Swiss Institute of Bioinformatics, Lausanne, Switzerland Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="O Connell, Jeffrey R" sort="O Connell, Jeffrey R" uniqKey="O Connell J" first="Jeffrey R" last="O'Connell">Jeffrey R. O'Connell</name><affiliation><nlm:affiliation>Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.</nlm:affiliation></affiliation></author><author><name sortKey="Parsa, Afshin" sort="Parsa, Afshin" uniqKey="Parsa A" first="Afshin" last="Parsa">Afshin Parsa</name><affiliation><nlm:affiliation>Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.</nlm:affiliation></affiliation></author><author><name sortKey="Heid, Iris M" sort="Heid, Iris M" uniqKey="Heid I" first="Iris M" last="Heid">Iris M. Heid</name><affiliation><nlm:affiliation>Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Paterson, Andrew D" sort="Paterson, Andrew D" uniqKey="Paterson A" first="Andrew D" last="Paterson">Andrew D. Paterson</name><affiliation><nlm:affiliation>Genetics and Genome Biology Program, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="De Boer, Ian H" sort="De Boer, Ian H" uniqKey="De Boer I" first="Ian H" last="De Boer">Ian H. De Boer</name><affiliation><nlm:affiliation>Kidney Research Institute, Department of Medicine, University of Washington, Seattle, WA.</nlm:affiliation></affiliation></author><author><name sortKey="Devuyst, Olivier" sort="Devuyst, Olivier" uniqKey="Devuyst O" first="Olivier" last="Devuyst">Olivier Devuyst</name><affiliation><nlm:affiliation>Institute of Physiology, Mechanisms of Inherited Kidney Disorders Group, University of Zürich, Zürich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Lazar, Jozef" sort="Lazar, Jozef" uniqKey="Lazar J" first="Jozef" last="Lazar">Jozef Lazar</name><affiliation><nlm:affiliation>Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI.</nlm:affiliation></affiliation></author><author><name sortKey="Endlich, Karlhans" sort="Endlich, Karlhans" uniqKey="Endlich K" first="Karlhans" last="Endlich">Karlhans Endlich</name><affiliation><nlm:affiliation>Institute of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Susztak, Katalin" sort="Susztak, Katalin" uniqKey="Susztak K" first="Katalin" last="Susztak">Katalin Susztak</name><affiliation><nlm:affiliation>Renal-Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, PA.</nlm:affiliation></affiliation></author><author><name sortKey="Tremblay, Johanne" sort="Tremblay, Johanne" uniqKey="Tremblay J" first="Johanne" last="Tremblay">Johanne Tremblay</name><affiliation><nlm:affiliation>Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), University of Montreal, CHUM Research Center, Technopìle Angus, Montreal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Hamet, Pavel" sort="Hamet, Pavel" uniqKey="Hamet P" first="Pavel" last="Hamet">Pavel Hamet</name><affiliation><nlm:affiliation>Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), University of Montreal, CHUM Research Center, Technopìle Angus, Montreal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Jacob, Howard J" sort="Jacob, Howard J" uniqKey="Jacob H" first="Howard J" last="Jacob">Howard J. Jacob</name><affiliation><nlm:affiliation>Department of Physiology, Medical College of Wisconsin, Milwaukee, WI.</nlm:affiliation></affiliation></author><author><name sortKey="Boger, Carsten A" sort="Boger, Carsten A" uniqKey="Boger C" first="Carsten A" last="Böger">Carsten A. Böger</name><affiliation><nlm:affiliation>Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S" last="Fox">Caroline S. Fox</name><affiliation><nlm:affiliation>National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, MA Division of Endocrinology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA anna.koettgen@uniklinik-freiburg.de ateumer@uni-greifswald.de foxca@nhlbi.nih.gov cristian.pattaro@eurac.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Pattaro, Cristian" sort="Pattaro, Cristian" uniqKey="Pattaro C" first="Cristian" last="Pattaro">Cristian Pattaro</name><affiliation><nlm:affiliation>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck, Bolzano, Italy anna.koettgen@uniklinik-freiburg.de ateumer@uni-greifswald.de foxca@nhlbi.nih.gov cristian.pattaro@eurac.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Kottgen, Anna" sort="Kottgen, Anna" uniqKey="Kottgen A" first="Anna" last="Köttgen">Anna Köttgen</name><affiliation><nlm:affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Renal Division, Medical Center, University of Freiburg, Freiburg, Germany anna.koettgen@uniklinik-freiburg.de ateumer@uni-greifswald.de foxca@nhlbi.nih.gov cristian.pattaro@eurac.edu.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26631737</idno><idno type="pmid">26631737</idno><idno type="doi">10.2337/db15-1313</idno><idno type="wicri:Area/PubMed/Corpus">002209</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002209</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.</title><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation><nlm:affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany German Center for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany anna.koettgen@uniklinik-freiburg.de ateumer@uni-greifswald.de foxca@nhlbi.nih.gov cristian.pattaro@eurac.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Tin, Adrienne" sort="Tin, Adrienne" uniqKey="Tin A" first="Adrienne" last="Tin">Adrienne Tin</name><affiliation><nlm:affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.</nlm:affiliation></affiliation></author><author><name sortKey="Sorice, Rossella" sort="Sorice, Rossella" uniqKey="Sorice R" first="Rossella" last="Sorice">Rossella Sorice</name><affiliation><nlm:affiliation>Institute of Genetics and Biophysics, "Adriano-Buzzati Traverso," Consiglio Nazionale delle Ricerche, Naples, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Gorski, Mathias" sort="Gorski, Mathias" uniqKey="Gorski M" first="Mathias" last="Gorski">Mathias Gorski</name><affiliation><nlm:affiliation>Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Yeo, Nan Cher" sort="Yeo, Nan Cher" uniqKey="Yeo N" first="Nan Cher" last="Yeo">Nan Cher Yeo</name><affiliation><nlm:affiliation>Department of Physiology, Medical College of Wisconsin, Milwaukee, WI.</nlm:affiliation></affiliation></author><author><name sortKey="Chu, Audrey Y" sort="Chu, Audrey Y" uniqKey="Chu A" first="Audrey Y" last="Chu">Audrey Y. Chu</name><affiliation><nlm:affiliation>Preventive Medicine, Brigham and Women's Hospital, Boston, MA National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, MA.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Man" sort="Li, Man" uniqKey="Li M" first="Man" last="Li">Man Li</name><affiliation><nlm:affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Yong" sort="Li, Yong" uniqKey="Li Y" first="Yong" last="Li">Yong Li</name><affiliation><nlm:affiliation>Renal Division, Medical Center, University of Freiburg, Freiburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Mijatovic, Vladan" sort="Mijatovic, Vladan" uniqKey="Mijatovic V" first="Vladan" last="Mijatovic">Vladan Mijatovic</name><affiliation><nlm:affiliation>Department of Life and Reproduction Sciences, University of Verona, Verona, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Ko, Yi An" sort="Ko, Yi An" uniqKey="Ko Y" first="Yi-An" last="Ko">Yi-An Ko</name><affiliation><nlm:affiliation>Renal-Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, PA.</nlm:affiliation></affiliation></author><author><name sortKey="Taliun, Daniel" sort="Taliun, Daniel" uniqKey="Taliun D" first="Daniel" last="Taliun">Daniel Taliun</name><affiliation><nlm:affiliation>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck, Bolzano, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Luciani, Alessandro" sort="Luciani, Alessandro" uniqKey="Luciani A" first="Alessandro" last="Luciani">Alessandro Luciani</name><affiliation><nlm:affiliation>Institute of Physiology, Mechanisms of Inherited Kidney Disorders Group, University of Zürich, Zürich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Ming Huei" sort="Chen, Ming Huei" uniqKey="Chen M" first="Ming-Huei" last="Chen">Ming-Huei Chen</name><affiliation><nlm:affiliation>Department of Neurology, Boston University School of Medicine, Boston, MA Department of Biostatistics, Boston University School of Public Health, Boston, MA.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name><affiliation><nlm:affiliation>Department of Biostatistics, Boston University School of Public Health, Boston, MA.</nlm:affiliation></affiliation></author><author><name sortKey="Foster, Meredith C" sort="Foster, Meredith C" uniqKey="Foster M" first="Meredith C" last="Foster">Meredith C. Foster</name><affiliation><nlm:affiliation>Tufts Medical Center, Boston, MA.</nlm:affiliation></affiliation></author><author><name sortKey="Olden, Matthias" sort="Olden, Matthias" uniqKey="Olden M" first="Matthias" last="Olden">Matthias Olden</name><affiliation><nlm:affiliation>Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany Department of Epidemiology and Preventive Medicine, Regensburg University Medical Center, Regensburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hiraki, Linda T" sort="Hiraki, Linda T" uniqKey="Hiraki L" first="Linda T" last="Hiraki">Linda T. Hiraki</name><affiliation><nlm:affiliation>Genetics and Genome Biology Program, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Tayo, Bamidele O" sort="Tayo, Bamidele O" uniqKey="Tayo B" first="Bamidele O" last="Tayo">Bamidele O. Tayo</name><affiliation><nlm:affiliation>Loyola University Chicago, Maywood, IL.</nlm:affiliation></affiliation></author><author><name sortKey="Fuchsberger, Christian" sort="Fuchsberger, Christian" uniqKey="Fuchsberger C" first="Christian" last="Fuchsberger">Christian Fuchsberger</name><affiliation><nlm:affiliation>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck, Bolzano, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Dieffenbach, Aida Karina" sort="Dieffenbach, Aida Karina" uniqKey="Dieffenbach A" first="Aida Karina" last="Dieffenbach">Aida Karina Dieffenbach</name><affiliation><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany German Cancer Consortium (DKTK), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R" last="Shuldiner">Alan R. Shuldiner</name><affiliation><nlm:affiliation>Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V" last="Smith">Albert V. Smith</name><affiliation><nlm:affiliation>Icelandic Heart Association, Kópavogur, Iceland Faculty of Medicine, University of Iceland, Reykjavik, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Zappa, Allison M" sort="Zappa, Allison M" uniqKey="Zappa A" first="Allison M" last="Zappa">Allison M. Zappa</name><affiliation><nlm:affiliation>Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI.</nlm:affiliation></affiliation></author><author><name sortKey="Lupo, Antonio" sort="Lupo, Antonio" uniqKey="Lupo A" first="Antonio" last="Lupo">Antonio Lupo</name><affiliation><nlm:affiliation>Renal Unit, Department of Medicine, University of Verona, Verona, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Kollerits, Barbara" sort="Kollerits, Barbara" uniqKey="Kollerits B" first="Barbara" last="Kollerits">Barbara Kollerits</name><affiliation><nlm:affiliation>Division of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Ponte, Belen" sort="Ponte, Belen" uniqKey="Ponte B" first="Belen" last="Ponte">Belen Ponte</name><affiliation><nlm:affiliation>Nephrology Division, Department of Specialties of Internal Medicine, Geneva University Hospitals, Geneva, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Stengel, Benedicte" sort="Stengel, Benedicte" uniqKey="Stengel B" first="Bénédicte" last="Stengel">Bénédicte Stengel</name><affiliation><nlm:affiliation>INSERM U-1018, Centre de recherche en épidémiologie et santé des populations (CESP) Team 5, Villejuif, France UMRS 1018, Centre de recherche en épidémiologie et santé des populations (CESP) Team 5, Univ Paris Sud, Univ Versailles, St. Quentin, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kr Mer, Bernhard K" sort="Kr Mer, Bernhard K" uniqKey="Kr Mer B" first="Bernhard K" last="Kr Mer">Bernhard K. Kr Mer</name><affiliation><nlm:affiliation>Fifth Department of Medicine, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Paulweber, Bernhard" sort="Paulweber, Bernhard" uniqKey="Paulweber B" first="Bernhard" last="Paulweber">Bernhard Paulweber</name><affiliation><nlm:affiliation>First Department of Internal Medicine, Paracelsus Medical University/Salzburger Landeskliniken, Salzburg, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D" last="Mitchell">Braxton D. Mitchell</name><affiliation><nlm:affiliation>Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.</nlm:affiliation></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation><nlm:affiliation>Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, U.K.</nlm:affiliation></affiliation></author><author><name sortKey="Helmer, Catherine" sort="Helmer, Catherine" uniqKey="Helmer C" first="Catherine" last="Helmer">Catherine Helmer</name><affiliation><nlm:affiliation>INSERM U897, Bordeaux University, Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Meisinger, Christa" sort="Meisinger, Christa" uniqKey="Meisinger C" first="Christa" last="Meisinger">Christa Meisinger</name><affiliation><nlm:affiliation>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation><nlm:affiliation>Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Shaffer, Christian M" sort="Shaffer, Christian M" uniqKey="Shaffer C" first="Christian M" last="Shaffer">Christian M. Shaffer</name><affiliation><nlm:affiliation>Vanderbilt University School of Medicine, Nashville, TN.</nlm:affiliation></affiliation></author><author><name sortKey="Muller, Christian" sort="Muller, Christian" uniqKey="Muller C" first="Christian" last="Müller">Christian Müller</name><affiliation><nlm:affiliation>University Heart Center Hamburg, Hamburg, Germany German Center for Cardiovascular Research (DZHK e.V.), partner site Hamburg, Lübeck, Kiel, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation><nlm:affiliation>Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, U.K.</nlm:affiliation></affiliation></author><author><name sortKey="Ackermann, Daniel" sort="Ackermann, Daniel" uniqKey="Ackermann D" first="Daniel" last="Ackermann">Daniel Ackermann</name><affiliation><nlm:affiliation>University Clinic for Nephrology, Hypertension and Clinical Pharmacology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Siscovick, David" sort="Siscovick, David" uniqKey="Siscovick D" first="David" last="Siscovick">David Siscovick</name><affiliation><nlm:affiliation>Cardiovascular Health Research Unit, Departments of Epidemiology and Medicine, University of Washington, Seattle, WA.</nlm:affiliation></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation><nlm:affiliation>Human Genetics Center, University of Texas Health Science Center, Houston, TX.</nlm:affiliation></affiliation></author><author><name sortKey="Kronenberg, Florian" sort="Kronenberg, Florian" uniqKey="Kronenberg F" first="Florian" last="Kronenberg">Florian Kronenberg</name><affiliation><nlm:affiliation>Division of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Ehret, Georg B" sort="Ehret, Georg B" uniqKey="Ehret G" first="Georg B" last="Ehret">Georg B. Ehret</name><affiliation><nlm:affiliation>Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospitals, Geneva, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name><affiliation><nlm:affiliation>Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Waeber, Gerard" sort="Waeber, Gerard" uniqKey="Waeber G" first="Gerard" last="Waeber">Gerard Waeber</name><affiliation><nlm:affiliation>Department of Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Navis, Gerjan" sort="Navis, Gerjan" uniqKey="Navis G" first="Gerjan" last="Navis">Gerjan Navis</name><affiliation><nlm:affiliation>Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Gambaro, Giovanni" sort="Gambaro, Giovanni" uniqKey="Gambaro G" first="Giovanni" last="Gambaro">Giovanni Gambaro</name><affiliation><nlm:affiliation>Division of Nephrology, Department of Internal Medicine and Medical Specialties, Columbus-Gemelli University Hospital, Catholic University, Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Malerba, Giovanni" sort="Malerba, Giovanni" uniqKey="Malerba G" first="Giovanni" last="Malerba">Giovanni Malerba</name><affiliation><nlm:affiliation>Department of Life and Reproduction Sciences, University of Verona, Verona, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation><nlm:affiliation>Icelandic Heart Association, Kópavogur, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Guo" sort="Li, Guo" uniqKey="Li G" first="Guo" last="Li">Guo Li</name><affiliation><nlm:affiliation>Cardiovascular Health Research Unit, Departments of Epidemiology and Medicine, University of Washington, Seattle, WA.</nlm:affiliation></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H Erich" last="Wichmann">H Erich Wichmann</name><affiliation><nlm:affiliation>Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany Institute of Medical Statistics and Epidemiology, Technical University Munich, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Grallert, Harald" sort="Grallert, Harald" uniqKey="Grallert H" first="Harald" last="Grallert">Harald Grallert</name><affiliation><nlm:affiliation>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany German Center for Diabetes Research (DZD), Neuherberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Wallaschofski, Henri" sort="Wallaschofski, Henri" uniqKey="Wallaschofski H" first="Henri" last="Wallaschofski">Henri Wallaschofski</name><affiliation><nlm:affiliation>Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation><nlm:affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany German Center for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Brenner, Herrmann" sort="Brenner, Herrmann" uniqKey="Brenner H" first="Herrmann" last="Brenner">Herrmann Brenner</name><affiliation><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kramer, Holly" sort="Kramer, Holly" uniqKey="Kramer H" first="Holly" last="Kramer">Holly Kramer</name><affiliation><nlm:affiliation>Loyola University Chicago, Maywood, IL.</nlm:affiliation></affiliation></author><author><name sortKey="Mateo Leach, I" sort="Mateo Leach, I" uniqKey="Mateo Leach I" first="I" last="Mateo Leach">I. Mateo Leach</name><affiliation><nlm:affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation><nlm:affiliation>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, Scotland, U.K.</nlm:affiliation></affiliation></author><author><name sortKey="Hillege, Hans L" sort="Hillege, Hans L" uniqKey="Hillege H" first="Hans L" last="Hillege">Hans L. Hillege</name><affiliation><nlm:affiliation>Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Beckmann, Jacques S" sort="Beckmann, Jacques S" uniqKey="Beckmann J" first="Jacques S" last="Beckmann">Jacques S. Beckmann</name><affiliation><nlm:affiliation>Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland Swiss Institute of Bioinformatics, Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean Charles" last="Lambert">Jean Charles Lambert</name><affiliation><nlm:affiliation>INSERM UMR 1167 "Risk factors and molecular determinants of aging-related diseases," Institut Pasteur de Lille, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Luan, Jian An" sort="Luan, Jian An" uniqKey="Luan J" first="Jian'An" last="Luan">Jian'An Luan</name><affiliation><nlm:affiliation>Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, U.K.</nlm:affiliation></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:affiliation>Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, U.K.</nlm:affiliation></affiliation></author><author><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name><affiliation><nlm:affiliation>The George Institute for Global Health, University of Sydney, Camperdown, New South Wales, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Coresh, Josef" sort="Coresh, Josef" uniqKey="Coresh J" first="Josef" last="Coresh">Josef Coresh</name><affiliation><nlm:affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Welch Center for Prevention, Epidemiology and Clinical Research, Baltimore, MD.</nlm:affiliation></affiliation></author><author><name sortKey="Denny, Joshua C" sort="Denny, Joshua C" uniqKey="Denny J" first="Joshua C" last="Denny">Joshua C. Denny</name><affiliation><nlm:affiliation>Vanderbilt University School of Medicine, Nashville, TN.</nlm:affiliation></affiliation></author><author><name sortKey="Butterbach, Katja" sort="Butterbach, Katja" uniqKey="Butterbach K" first="Katja" last="Butterbach">Katja Butterbach</name><affiliation><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name><affiliation><nlm:affiliation>Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD.</nlm:affiliation></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation><nlm:affiliation>Clinical Research Branch, National Institute on Aging, Baltimore, MD.</nlm:affiliation></affiliation></author><author><name sortKey="Kedenko, Lyudmyla" sort="Kedenko, Lyudmyla" uniqKey="Kedenko L" first="Lyudmyla" last="Kedenko">Lyudmyla Kedenko</name><affiliation><nlm:affiliation>First Department of Internal Medicine, Paracelsus Medical University/Salzburger Landeskliniken, Salzburg, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Haun, Margot" sort="Haun, Margot" uniqKey="Haun M" first="Margot" last="Haun">Margot Haun</name><affiliation><nlm:affiliation>Division of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Metzger, Marie" sort="Metzger, Marie" uniqKey="Metzger M" first="Marie" last="Metzger">Marie Metzger</name><affiliation><nlm:affiliation>INSERM U-1018, Centre de recherche en épidémiologie et santé des populations (CESP) Team 5, Villejuif, France UMRS 1018, Centre de recherche en épidémiologie et santé des populations (CESP) Team 5, Univ Paris Sud, Univ Versailles, St. Quentin, France.</nlm:affiliation></affiliation></author><author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name><affiliation><nlm:affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD The George Institute for Global Health, University of Sydney, Camperdown, New South Wales, Australia The George Institute for Global Health, Nuffield Department of Population Health, University of Oxford, Oxford, U.K.</nlm:affiliation></affiliation></author><author><name sortKey="Hoffman, Matthew J" sort="Hoffman, Matthew J" uniqKey="Hoffman M" first="Matthew J" last="Hoffman">Matthew J. Hoffman</name><affiliation><nlm:affiliation>Department of Physiology, Medical College of Wisconsin, Milwaukee, WI.</nlm:affiliation></affiliation></author><author><name sortKey="Nauck, Matthias" sort="Nauck, Matthias" uniqKey="Nauck M" first="Matthias" last="Nauck">Matthias Nauck</name><affiliation><nlm:affiliation>German Center for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Waldenberger, Melanie" sort="Waldenberger, Melanie" uniqKey="Waldenberger M" first="Melanie" last="Waldenberger">Melanie Waldenberger</name><affiliation><nlm:affiliation>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Pruijm, Menno" sort="Pruijm, Menno" uniqKey="Pruijm M" first="Menno" last="Pruijm">Menno Pruijm</name><affiliation><nlm:affiliation>Service of Nephrology, Lausanne University Hospital, Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Bochud, Murielle" sort="Bochud, Murielle" uniqKey="Bochud M" first="Murielle" last="Bochud">Murielle Bochud</name><affiliation><nlm:affiliation>University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Épalinges, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Rheinberger, Myriam" sort="Rheinberger, Myriam" uniqKey="Rheinberger M" first="Myriam" last="Rheinberger">Myriam Rheinberger</name><affiliation><nlm:affiliation>Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Verweij, Niek" sort="Verweij, Niek" uniqKey="Verweij N" first="Niek" last="Verweij">Niek Verweij</name><affiliation><nlm:affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:affiliation>Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, U.K.</nlm:affiliation></affiliation></author><author><name sortKey="Endlich, Nicole" sort="Endlich, Nicole" uniqKey="Endlich N" first="Nicole" last="Endlich">Nicole Endlich</name><affiliation><nlm:affiliation>Institute of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation><nlm:affiliation>Human Genetics, Wellcome Trust Sanger Institute, Hinxton, U.K. Department of Haematology, University of Cambridge, Cambridge, U.K.</nlm:affiliation></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation><nlm:affiliation>Croatian Centre for Global Health, Faculty of Medicine, University of Split, Split, Croatia.</nlm:affiliation></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation><nlm:affiliation>Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Pramstaller, Peter Paul" sort="Pramstaller, Peter Paul" uniqKey="Pramstaller P" first="Peter Paul" last="Pramstaller">Peter Paul Pramstaller</name><affiliation><nlm:affiliation>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck, Bolzano, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation><nlm:affiliation>Department of Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Wild, Philipp S" sort="Wild, Philipp S" uniqKey="Wild P" first="Philipp S" last="Wild">Philipp S. Wild</name><affiliation><nlm:affiliation>Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg, University Mainz, Mainz, Germany Preventive Cardiology and Preventive Medicine, Department of Medicine 2, University Medical Center of the Johannes Gutenberg, University Mainz, Mainz, Germany German Center for Cardiovascular Research (DZHK), Mainz, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Gansevoort, Ron T" sort="Gansevoort, Ron T" uniqKey="Gansevoort R" first="Ron T" last="Gansevoort">Ron T. Gansevoort</name><affiliation><nlm:affiliation>Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Rettig, Rainer" sort="Rettig, Rainer" uniqKey="Rettig R" first="Rainer" last="Rettig">Rainer Rettig</name><affiliation><nlm:affiliation>Institute of Physiology, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Biffar, Reiner" sort="Biffar, Reiner" uniqKey="Biffar R" first="Reiner" last="Biffar">Reiner Biffar</name><affiliation><nlm:affiliation>Clinic for Prosthetic Dentistry, Gerostomatology and Material Science, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Carroll, Robert J" sort="Carroll, Robert J" uniqKey="Carroll R" first="Robert J" last="Carroll">Robert J. Carroll</name><affiliation><nlm:affiliation>Vanderbilt University School of Medicine, Nashville, TN.</nlm:affiliation></affiliation></author><author><name sortKey="Katz, Ronit" sort="Katz, Ronit" uniqKey="Katz R" first="Ronit" last="Katz">Ronit Katz</name><affiliation><nlm:affiliation>Kidney Research Institute, Department of Medicine, University of Washington, Seattle, WA.</nlm:affiliation></affiliation></author><author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J F" last="Loos">Ruth J F. Loos</name><affiliation><nlm:affiliation>Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, U.K. Genetics of Obesity and Related Metabolic Traits Program, The Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Hwang, Shih Jen" sort="Hwang, Shih Jen" uniqKey="Hwang S" first="Shih-Jen" last="Hwang">Shih-Jen Hwang</name><affiliation><nlm:affiliation>National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, MA.</nlm:affiliation></affiliation></author><author><name sortKey="Coassin, Stefan" sort="Coassin, Stefan" uniqKey="Coassin S" first="Stefan" last="Coassin">Stefan Coassin</name><affiliation><nlm:affiliation>Division of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Bergmann, Sven" sort="Bergmann, Sven" uniqKey="Bergmann S" first="Sven" last="Bergmann">Sven Bergmann</name><affiliation><nlm:affiliation>Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Rosas, Sylvia E" sort="Rosas, Sylvia E" uniqKey="Rosas S" first="Sylvia E" last="Rosas">Sylvia E. Rosas</name><affiliation><nlm:affiliation>Kidney and Hypertension Section, Joslin Diabetes Center and Harvard Medical School, Boston, MA.</nlm:affiliation></affiliation></author><author><name sortKey="Stracke, Sylvia" sort="Stracke, Sylvia" uniqKey="Stracke S" first="Sylvia" last="Stracke">Sylvia Stracke</name><affiliation><nlm:affiliation>Clinic for Internal Medicine A, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B" last="Harris">Tamara B. Harris</name><affiliation><nlm:affiliation>Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD.</nlm:affiliation></affiliation></author><author><name sortKey="Corre, Tanguy" sort="Corre, Tanguy" uniqKey="Corre T" first="Tanguy" last="Corre">Tanguy Corre</name><affiliation><nlm:affiliation>Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Zeller, Tanja" sort="Zeller, Tanja" uniqKey="Zeller T" first="Tanja" last="Zeller">Tanja Zeller</name><affiliation><nlm:affiliation>University Heart Center Hamburg, Hamburg, Germany German Center for Cardiovascular Research (DZHK e.V.), partner site Hamburg, Lübeck, Kiel, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><affiliation><nlm:affiliation>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany Institute for Human Genetics, Hannover Medical School, Hannover, Germany Hannover Unified Biobank, Hannover Medical School, Hannover, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Aspelund, Thor" sort="Aspelund, Thor" uniqKey="Aspelund T" first="Thor" last="Aspelund">Thor Aspelund</name><affiliation><nlm:affiliation>Icelandic Heart Association, Kópavogur, Iceland Faculty of Medicine, University of Iceland, Reykjavik, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name><affiliation><nlm:affiliation>Clinical Research Branch, National Institute on Aging, Baltimore, MD.</nlm:affiliation></affiliation></author><author><name sortKey="Lendeckel, Uwe" sort="Lendeckel, Uwe" uniqKey="Lendeckel U" first="Uwe" last="Lendeckel">Uwe Lendeckel</name><affiliation><nlm:affiliation>Institute of Medical Biochemistry and Molecular Biology, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><affiliation><nlm:affiliation>German Center for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:affiliation>Icelandic Heart Association, Kópavogur, Iceland Faculty of Medicine, University of Iceland, Reykjavik, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name><affiliation><nlm:affiliation>INSERM UMR 1167 "Risk factors and molecular determinants of aging-related diseases," Institut Pasteur de Lille, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name><affiliation><nlm:affiliation>Abteilung Innere II, Universitätsklinikum Ulm, Ulm, Germany Deutsches Herzzentrum München, Technische Universität München, Munich, Germany German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltan" last="Kutalik">Zoltan Kutalik</name><affiliation><nlm:affiliation>Swiss Institute of Bioinformatics, Lausanne, Switzerland Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="O Connell, Jeffrey R" sort="O Connell, Jeffrey R" uniqKey="O Connell J" first="Jeffrey R" last="O'Connell">Jeffrey R. O'Connell</name><affiliation><nlm:affiliation>Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.</nlm:affiliation></affiliation></author><author><name sortKey="Parsa, Afshin" sort="Parsa, Afshin" uniqKey="Parsa A" first="Afshin" last="Parsa">Afshin Parsa</name><affiliation><nlm:affiliation>Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.</nlm:affiliation></affiliation></author><author><name sortKey="Heid, Iris M" sort="Heid, Iris M" uniqKey="Heid I" first="Iris M" last="Heid">Iris M. Heid</name><affiliation><nlm:affiliation>Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Paterson, Andrew D" sort="Paterson, Andrew D" uniqKey="Paterson A" first="Andrew D" last="Paterson">Andrew D. Paterson</name><affiliation><nlm:affiliation>Genetics and Genome Biology Program, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="De Boer, Ian H" sort="De Boer, Ian H" uniqKey="De Boer I" first="Ian H" last="De Boer">Ian H. De Boer</name><affiliation><nlm:affiliation>Kidney Research Institute, Department of Medicine, University of Washington, Seattle, WA.</nlm:affiliation></affiliation></author><author><name sortKey="Devuyst, Olivier" sort="Devuyst, Olivier" uniqKey="Devuyst O" first="Olivier" last="Devuyst">Olivier Devuyst</name><affiliation><nlm:affiliation>Institute of Physiology, Mechanisms of Inherited Kidney Disorders Group, University of Zürich, Zürich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Lazar, Jozef" sort="Lazar, Jozef" uniqKey="Lazar J" first="Jozef" last="Lazar">Jozef Lazar</name><affiliation><nlm:affiliation>Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI.</nlm:affiliation></affiliation></author><author><name sortKey="Endlich, Karlhans" sort="Endlich, Karlhans" uniqKey="Endlich K" first="Karlhans" last="Endlich">Karlhans Endlich</name><affiliation><nlm:affiliation>Institute of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Susztak, Katalin" sort="Susztak, Katalin" uniqKey="Susztak K" first="Katalin" last="Susztak">Katalin Susztak</name><affiliation><nlm:affiliation>Renal-Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, PA.</nlm:affiliation></affiliation></author><author><name sortKey="Tremblay, Johanne" sort="Tremblay, Johanne" uniqKey="Tremblay J" first="Johanne" last="Tremblay">Johanne Tremblay</name><affiliation><nlm:affiliation>Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), University of Montreal, CHUM Research Center, Technopìle Angus, Montreal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Hamet, Pavel" sort="Hamet, Pavel" uniqKey="Hamet P" first="Pavel" last="Hamet">Pavel Hamet</name><affiliation><nlm:affiliation>Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), University of Montreal, CHUM Research Center, Technopìle Angus, Montreal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Jacob, Howard J" sort="Jacob, Howard J" uniqKey="Jacob H" first="Howard J" last="Jacob">Howard J. Jacob</name><affiliation><nlm:affiliation>Department of Physiology, Medical College of Wisconsin, Milwaukee, WI.</nlm:affiliation></affiliation></author><author><name sortKey="Boger, Carsten A" sort="Boger, Carsten A" uniqKey="Boger C" first="Carsten A" last="Böger">Carsten A. Böger</name><affiliation><nlm:affiliation>Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S" last="Fox">Caroline S. Fox</name><affiliation><nlm:affiliation>National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, MA Division of Endocrinology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA anna.koettgen@uniklinik-freiburg.de ateumer@uni-greifswald.de foxca@nhlbi.nih.gov cristian.pattaro@eurac.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Pattaro, Cristian" sort="Pattaro, Cristian" uniqKey="Pattaro C" first="Cristian" last="Pattaro">Cristian Pattaro</name><affiliation><nlm:affiliation>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck, Bolzano, Italy anna.koettgen@uniklinik-freiburg.de ateumer@uni-greifswald.de foxca@nhlbi.nih.gov cristian.pattaro@eurac.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Kottgen, Anna" sort="Kottgen, Anna" uniqKey="Kottgen A" first="Anna" last="Köttgen">Anna Köttgen</name><affiliation><nlm:affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Renal Division, Medical Center, University of Freiburg, Freiburg, Germany anna.koettgen@uniklinik-freiburg.de ateumer@uni-greifswald.de foxca@nhlbi.nih.gov cristian.pattaro@eurac.edu.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Diabetes</title><idno type="eISSN">1939-327X</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Albuminuria (etiology)</term><term>Albuminuria (genetics)</term><term>Animals</term><term>Cathepsin C (genetics)</term><term>Diabetes Mellitus, Experimental</term><term>Diabetes Mellitus, Type 2 (complications)</term><term>Diabetes Mellitus, Type 2 (genetics)</term><term>Diabetic Nephropathies (etiology)</term><term>Diabetic Nephropathies (genetics)</term><term>Female</term><term>Gene Knockout Techniques</term><term>Genetic Predisposition to Disease</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Kidney (metabolism)</term><term>Kidney Tubules (metabolism)</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Rats</term><term>Receptors, Cell Surface (genetics)</term><term>Sulfotransferases (genetics)</term><term>rab GTP-Binding Proteins (genetics)</term><term>rab GTP-Binding Proteins (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cathepsin C</term><term>Receptors, Cell Surface</term><term>Sulfotransferases</term><term>rab GTP-Binding Proteins</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Diabetes Mellitus, Type 2</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Albuminuria</term><term>Diabetic Nephropathies</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Albuminuria</term><term>Diabetes Mellitus, Type 2</term><term>Diabetic Nephropathies</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Kidney</term><term>Kidney Tubules</term><term>rab GTP-Binding Proteins</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Animals</term><term>Diabetes Mellitus, Experimental</term><term>Female</term><term>Gene Knockout Techniques</term><term>Genetic Predisposition to Disease</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Elevated concentrations of albumin in the urine, albuminuria, are a hallmark of diabetic kidney disease and are associated with an increased risk for end-stage renal disease and cardiovascular events. To gain insight into the pathophysiological mechanisms underlying albuminuria, we conducted meta-analyses of genome-wide association studies and independent replication in up to 5,825 individuals of European ancestry with diabetes and up to 46,061 without diabetes, followed by functional studies. Known associations of variants in CUBN, encoding cubilin, with the urinary albumin-to-creatinine ratio (UACR) were confirmed in the overall sample (P = 2.4 × 10(-10)). Gene-by-diabetes interactions were detected and confirmed for variants in HS6ST1 and near RAB38/CTSC. Single nucleotide polymorphisms at these loci demonstrated a genetic effect on UACR in individuals with but not without diabetes. The change in the average UACR per minor allele was 21% for HS6ST1 (P = 6.3 × 10(-7)) and 13% for RAB38/CTSC (P = 5.8 × 10(-7)). Experiments using streptozotocin-induced diabetic Rab38 knockout and control rats showed higher urinary albumin concentrations and reduced amounts of megalin and cubilin at the proximal tubule cell surface in Rab38 knockout versus control rats. Relative expression of RAB38 was higher in tubuli of patients with diabetic kidney disease compared with control subjects. The loci identified here confirm known pathways and highlight novel pathways influencing albuminuria.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26631737</PMID><DateCreated><Year>2016</Year><Month>02</Month><Day>24</Day></DateCreated><DateCompleted><Year>2016</Year><Month>07</Month><Day>06</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1939-327X</ISSN><JournalIssue CitedMedium="Internet"><Volume>65</Volume><Issue>3</Issue><PubDate><Year>2016</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Diabetes</Title><ISOAbbreviation>Diabetes</ISOAbbreviation></Journal><ArticleTitle>Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.</ArticleTitle><Pagination><MedlinePgn>803-17</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.2337/db15-1313</ELocationID><Abstract><AbstractText>Elevated concentrations of albumin in the urine, albuminuria, are a hallmark of diabetic kidney disease and are associated with an increased risk for end-stage renal disease and cardiovascular events. To gain insight into the pathophysiological mechanisms underlying albuminuria, we conducted meta-analyses of genome-wide association studies and independent replication in up to 5,825 individuals of European ancestry with diabetes and up to 46,061 without diabetes, followed by functional studies. Known associations of variants in CUBN, encoding cubilin, with the urinary albumin-to-creatinine ratio (UACR) were confirmed in the overall sample (P = 2.4 × 10(-10)). Gene-by-diabetes interactions were detected and confirmed for variants in HS6ST1 and near RAB38/CTSC. Single nucleotide polymorphisms at these loci demonstrated a genetic effect on UACR in individuals with but not without diabetes. The change in the average UACR per minor allele was 21% for HS6ST1 (P = 6.3 × 10(-7)) and 13% for RAB38/CTSC (P = 5.8 × 10(-7)). Experiments using streptozotocin-induced diabetic Rab38 knockout and control rats showed higher urinary albumin concentrations and reduced amounts of megalin and cubilin at the proximal tubule cell surface in Rab38 knockout versus control rats. Relative expression of RAB38 was higher in tubuli of patients with diabetic kidney disease compared with control subjects. The loci identified here confirm known pathways and highlight novel pathways influencing albuminuria.</AbstractText><CopyrightInformation>© 2016 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Teumer</LastName><ForeName>Alexander</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany German Center for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany anna.koettgen@uniklinik-freiburg.de ateumer@uni-greifswald.de foxca@nhlbi.nih.gov cristian.pattaro@eurac.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tin</LastName><ForeName>Adrienne</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sorice</LastName><ForeName>Rossella</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Institute of Genetics and Biophysics, "Adriano-Buzzati Traverso," Consiglio Nazionale delle Ricerche, Naples, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gorski</LastName><ForeName>Mathias</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yeo</LastName><ForeName>Nan Cher</ForeName><Initials>NC</Initials><AffiliationInfo><Affiliation>Department of Physiology, Medical College of Wisconsin, Milwaukee, WI.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chu</LastName><ForeName>Audrey Y</ForeName><Initials>AY</Initials><AffiliationInfo><Affiliation>Preventive Medicine, Brigham and Women's Hospital, Boston, MA National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, MA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Man</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Yong</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Renal Division, Medical Center, University of Freiburg, Freiburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mijatovic</LastName><ForeName>Vladan</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Life and Reproduction Sciences, University of Verona, Verona, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ko</LastName><ForeName>Yi-An</ForeName><Initials>YA</Initials><AffiliationInfo><Affiliation>Renal-Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, PA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Taliun</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck, Bolzano, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Luciani</LastName><ForeName>Alessandro</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Physiology, Mechanisms of Inherited Kidney Disorders Group, University of Zürich, Zürich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Ming-Huei</ForeName><Initials>MH</Initials><AffiliationInfo><Affiliation>Department of Neurology, Boston University School of Medicine, Boston, MA Department of Biostatistics, Boston University School of Public Health, Boston, MA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Qiong</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, Boston University School of Public Health, Boston, MA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Foster</LastName><ForeName>Meredith C</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Tufts Medical Center, Boston, MA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olden</LastName><ForeName>Matthias</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany Department of Epidemiology and Preventive Medicine, Regensburg University Medical Center, Regensburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hiraki</LastName><ForeName>Linda T</ForeName><Initials>LT</Initials><AffiliationInfo><Affiliation>Genetics and Genome Biology Program, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tayo</LastName><ForeName>Bamidele O</ForeName><Initials>BO</Initials><AffiliationInfo><Affiliation>Loyola University Chicago, Maywood, IL.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fuchsberger</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck, Bolzano, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dieffenbach</LastName><ForeName>Aida Karina</ForeName><Initials>AK</Initials><AffiliationInfo><Affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany German Cancer Consortium (DKTK), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shuldiner</LastName><ForeName>Alan R</ForeName><Initials>AR</Initials><AffiliationInfo><Affiliation>Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>Albert V</ForeName><Initials>AV</Initials><AffiliationInfo><Affiliation>Icelandic Heart Association, Kópavogur, Iceland Faculty of Medicine, University of Iceland, Reykjavik, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zappa</LastName><ForeName>Allison 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ValidYN="Y"><LastName>Stengel</LastName><ForeName>Bénédicte</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>INSERM U-1018, Centre de recherche en épidémiologie et santé des populations (CESP) Team 5, Villejuif, France UMRS 1018, Centre de recherche en épidémiologie et santé des populations (CESP) Team 5, Univ Paris Sud, Univ Versailles, St. Quentin, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krämer</LastName><ForeName>Bernhard K</ForeName><Initials>BK</Initials><AffiliationInfo><Affiliation>Fifth Department of Medicine, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Paulweber</LastName><ForeName>Bernhard</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>First Department of Internal Medicine, Paracelsus Medical University/Salzburger Landeskliniken, Salzburg, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mitchell</LastName><ForeName>Braxton D</ForeName><Initials>BD</Initials><AffiliationInfo><Affiliation>Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hayward</LastName><ForeName>Caroline</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, U.K.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Helmer</LastName><ForeName>Catherine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>INSERM U897, Bordeaux University, Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meisinger</LastName><ForeName>Christa</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gieger</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shaffer</LastName><ForeName>Christian M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Vanderbilt University School of Medicine, Nashville, TN.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Müller</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>University Heart Center Hamburg, Hamburg, Germany German Center for Cardiovascular Research (DZHK e.V.), partner site Hamburg, Lübeck, Kiel, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Langenberg</LastName><ForeName>Claudia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, U.K.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ackermann</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>University Clinic for Nephrology, Hypertension and Clinical Pharmacology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Siscovick</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Cardiovascular Health Research Unit, Departments of Epidemiology and Medicine, University of Washington, Seattle, WA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>DCCT/EDIC</CollectiveName></Author><Author ValidYN="Y"><LastName>Boerwinkle</LastName><ForeName>Eric</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Human Genetics Center, University of Texas Health Science Center, Houston, TX.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kronenberg</LastName><ForeName>Florian</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Division of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ehret</LastName><ForeName>Georg B</ForeName><Initials>GB</Initials><AffiliationInfo><Affiliation>Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospitals, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Homuth</LastName><ForeName>Georg</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Waeber</LastName><ForeName>Gerard</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Navis</LastName><ForeName>Gerjan</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gambaro</LastName><ForeName>Giovanni</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Division of Nephrology, Department of Internal Medicine and Medical Specialties, Columbus-Gemelli University Hospital, Catholic University, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Malerba</LastName><ForeName>Giovanni</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Life and Reproduction Sciences, University of Verona, Verona, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eiriksdottir</LastName><ForeName>Gudny</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Icelandic Heart Association, Kópavogur, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Guo</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Cardiovascular Health Research Unit, Departments of Epidemiology and Medicine, University of Washington, Seattle, WA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wichmann</LastName><ForeName>H Erich</ForeName><Initials>HE</Initials><AffiliationInfo><Affiliation>Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany 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Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Völzke</LastName><ForeName>Henry</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany German Center for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brenner</LastName><ForeName>Herrmann</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kramer</LastName><ForeName>Holly</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Loyola University Chicago, Maywood, IL.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mateo Leach</LastName><ForeName>I</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rudan</LastName><ForeName>Igor</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, Scotland, U.K.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hillege</LastName><ForeName>Hans L</ForeName><Initials>HL</Initials><AffiliationInfo><Affiliation>Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beckmann</LastName><ForeName>Jacques S</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>Service of Medical Genetics, Centre Hospitalier Universitaire 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Nephrology, University Hospital Regensburg, Regensburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Verweij</LastName><ForeName>Niek</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wareham</LastName><ForeName>Nicholas J</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, U.K.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Endlich</LastName><ForeName>Nicole</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Institute of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Soranzo</LastName><ForeName>Nicole</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Human Genetics, Wellcome Trust Sanger Institute, Hinxton, U.K. Department of Haematology, University of Cambridge, Cambridge, U.K.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Polasek</LastName><ForeName>Ozren</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Croatian Centre for Global Health, Faculty of Medicine, University of Split, Split, Croatia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van der Harst</LastName><ForeName>Pim</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pramstaller</LastName><ForeName>Peter Paul</ForeName><Initials>PP</Initials><AffiliationInfo><Affiliation>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck, Bolzano, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vollenweider</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wild</LastName><ForeName>Philipp S</ForeName><Initials>PS</Initials><AffiliationInfo><Affiliation>Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg, University Mainz, Mainz, Germany Preventive Cardiology and Preventive Medicine, Department of Medicine 2, University Medical Center of the Johannes Gutenberg, University Mainz, Mainz, Germany German Center for Cardiovascular Research (DZHK), Mainz, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gansevoort</LastName><ForeName>Ron 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TN.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Katz</LastName><ForeName>Ronit</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Kidney Research Institute, Department of Medicine, University of Washington, Seattle, WA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Loos</LastName><ForeName>Ruth J F</ForeName><Initials>RJ</Initials><AffiliationInfo><Affiliation>Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, U.K. Genetics of Obesity and Related Metabolic Traits Program, The Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, NY.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hwang</LastName><ForeName>Shih-Jen</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, MA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Coassin</LastName><ForeName>Stefan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bergmann</LastName><ForeName>Sven</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rosas</LastName><ForeName>Sylvia E</ForeName><Initials>SE</Initials><AffiliationInfo><Affiliation>Kidney and Hypertension Section, Joslin Diabetes Center and Harvard Medical School, Boston, MA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stracke</LastName><ForeName>Sylvia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Clinic for Internal Medicine A, University Medicine Greifswald, Greifswald, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harris</LastName><ForeName>Tamara B</ForeName><Initials>TB</Initials><AffiliationInfo><Affiliation>Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Corre</LastName><ForeName>Tanguy</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zeller</LastName><ForeName>Tanja</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>University Heart Center Hamburg, Hamburg, Germany German Center for Cardiovascular Research (DZHK e.V.), partner site Hamburg, Lübeck, Kiel, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Illig</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany Institute for Human Genetics, Hannover Medical School, Hannover, Germany Hannover Unified Biobank, Hannover Medical School, Hannover, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aspelund</LastName><ForeName>Thor</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Icelandic Heart Association, Kópavogur, Iceland Faculty of Medicine, University of Iceland, Reykjavik, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tanaka</LastName><ForeName>Toshiko</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Clinical Research Branch, National Institute on Aging, Baltimore, MD.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lendeckel</LastName><ForeName>Uwe</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Institute of Medical Biochemistry and Molecular Biology, University Medicine Greifswald, Greifswald, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Völker</LastName><ForeName>Uwe</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>German Center for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gudnason</LastName><ForeName>Vilmundur</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Icelandic Heart Association, Kópavogur, Iceland Faculty of Medicine, University of Iceland, Reykjavik, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chouraki</LastName><ForeName>Vincent</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>INSERM UMR 1167 "Risk factors and molecular determinants of aging-related diseases," Institut Pasteur de Lille, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Koenig</LastName><ForeName>Wolfgang</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Abteilung Innere II, Universitätsklinikum Ulm, Ulm, Germany Deutsches Herzzentrum München, Technische Universität München, Munich, Germany German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kutalik</LastName><ForeName>Zoltan</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Swiss Institute of Bioinformatics, Lausanne, Switzerland Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O'Connell</LastName><ForeName>Jeffrey R</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parsa</LastName><ForeName>Afshin</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heid</LastName><ForeName>Iris M</ForeName><Initials>IM</Initials><AffiliationInfo><Affiliation>Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Paterson</LastName><ForeName>Andrew D</ForeName><Initials>AD</Initials><AffiliationInfo><Affiliation>Genetics and Genome Biology Program, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Boer</LastName><ForeName>Ian H</ForeName><Initials>IH</Initials><AffiliationInfo><Affiliation>Kidney Research Institute, Department of Medicine, University of Washington, Seattle, WA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Devuyst</LastName><ForeName>Olivier</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Institute of Physiology, Mechanisms of Inherited Kidney Disorders Group, University of Zürich, Zürich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lazar</LastName><ForeName>Jozef</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Endlich</LastName><ForeName>Karlhans</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Institute of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Susztak</LastName><ForeName>Katalin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Renal-Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, PA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tremblay</LastName><ForeName>Johanne</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), University of Montreal, CHUM Research Center, Technopìle Angus, Montreal, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hamet</LastName><ForeName>Pavel</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), University of Montreal, CHUM Research Center, Technopìle Angus, Montreal, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jacob</LastName><ForeName>Howard J</ForeName><Initials>HJ</Initials><AffiliationInfo><Affiliation>Department of Physiology, Medical College of Wisconsin, Milwaukee, WI.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Böger</LastName><ForeName>Carsten A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fox</LastName><ForeName>Caroline S</ForeName><Initials>CS</Initials><AffiliationInfo><Affiliation>National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, MA Division of Endocrinology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA anna.koettgen@uniklinik-freiburg.de ateumer@uni-greifswald.de foxca@nhlbi.nih.gov cristian.pattaro@eurac.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pattaro</LastName><ForeName>Cristian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck, Bolzano, Italy anna.koettgen@uniklinik-freiburg.de ateumer@uni-greifswald.de foxca@nhlbi.nih.gov cristian.pattaro@eurac.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Köttgen</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Renal Division, Medical Center, University of Freiburg, Freiburg, Germany anna.koettgen@uniklinik-freiburg.de ateumer@uni-greifswald.de foxca@nhlbi.nih.gov cristian.pattaro@eurac.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>U01-GM-074518-04</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100012C</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>DK0-87635</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N02-HL-6-4278</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01-HC-25195</GrantID><Acronym>HC</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>2R01-LM0-10098</GrantID><Acronym>LM</Acronym><Agency>NLM NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01-HG0-04402</GrantID><Acronym>HG</Acronym><Agency>NHGRI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100009I</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 DK094176</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01-HC-95162</GrantID><Acronym>HC</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K12 RR023250</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United 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States</Country></Grant><Grant><GrantID>HHSN268201100005G</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01-HL-088119</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100008I</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01-HG04603</GrantID><Acronym>HG</Acronym><Agency>NHGRI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100005C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>F32 HL009367</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100007C</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL069321</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01-HC-95163</GrantID><Acronym>HC</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01 HC015103</GrantID><Acronym>HC</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01-HC-95168</GrantID><Acronym>HC</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01HC95169</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100009C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>R01-HL0-86694</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100011I</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 DK079637</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100011C</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL086694</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 HG004603</GrantID><Acronym>HG</Acronym><Agency>NHGRI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01-HC-95159</GrantID><Acronym>HC</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 DK087635</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL087652</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268200625226C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 HG004402</GrantID><Acronym>HG</Acronym><Agency>NHGRI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01-HC-95165</GrantID><Acronym>HC</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01HC95164</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01-AG-1-2100</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>WT098051</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>N01HC55222</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01-HC-85086</GrantID><Acronym>HC</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01HC95162</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100010C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01HC85086</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>MC_UU_12015/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>R01 HL105756</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01HC95168</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01-HL0-87652</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>M01-RR-00425</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>MC_U106179471</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>U01 HL084756</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 DK063491</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100006C</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><Agency>Intramural NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K12-RR0-23250</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant><Grant><GrantID>HHSN268201100008C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 DK072488</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100012C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><Agency>Cancer Research UK</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>HHSN271201200022C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01-HC-95169</GrantID><Acronym>HC</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100005I</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01-HC-95164</GrantID><Acronym>HC</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01HC95165</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01-DK0-76077</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01-HL0-84756</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01HC95159</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>RC2-GM092318</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01-HC-55222</GrantID><Acronym>HC</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 LM010098</GrantID><Acronym>LM</Acronym><Agency>NLM NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01-HL-071205</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>2R01-069321</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01HC95161</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01-HC-75150</GrantID><Acronym>HC</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 DK020541</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN271201200022C</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01-HC-95160</GrantID><Acronym>HC</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 HL072515</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>M01 RR016500</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01-HL0-87641</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100007C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>M01 RR000425</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01HC75150</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01HC95167</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>WT091310</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>U01 DK094157</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01-HL0-80295</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100009C</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100011C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100005C</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01HC25195</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL071205</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100007I</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01-HC-85079</GrantID><Acronym>HC</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01-HC-95161</GrantID><Acronym>HC</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>M01-RR-16500</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH 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DateType="Electronic"><Year>2015</Year><Month>12</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Diabetes</MedlineTA><NlmUniqueID>0372763</NlmUniqueID><ISSNLinking>0012-1797</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011956">Receptors, Cell Surface</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C029486">intrinsic factor-cobalamin receptor</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.8.2.-</RegistryNumber><NameOfSubstance UI="D015238">Sulfotransferases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.8.2.-</RegistryNumber><NameOfSubstance UI="C404189">heparan sulfate 6-O-sulfotransferase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.14.1</RegistryNumber><NameOfSubstance UI="C533918">CTSC protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 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