Human Adaptation of Ebola Virus during the West African Outbreak.
Identifieur interne : 001653 ( PubMed/Corpus ); précédent : 001652; suivant : 001654Human Adaptation of Ebola Virus during the West African Outbreak.
Auteurs : Richard A. Urbanowicz ; C Patrick Mcclure ; Anavaj Sakuntabhai ; Amadou A. Sall ; Gary Kobinger ; Marcel A. Müller ; Edward C. Holmes ; Félix A. Rey ; Etienne Simon-Loriere ; Jonathan K. BallSource :
- Cell [ 1097-4172 ] ; 2016.
English descriptors
- KwdEn :
- Africa, Western (epidemiology), Animals, Biological Evolution, Chiroptera (virology), Disease Outbreaks, Ebolavirus (classification), Ebolavirus (genetics), Ebolavirus (pathogenicity), Ebolavirus (physiology), Hemorrhagic Fever, Ebola (epidemiology), Hemorrhagic Fever, Ebola (transmission), Hemorrhagic Fever, Ebola (virology), Host Specificity, Humans, Mutation, Phylogeny, Viral Envelope Proteins (genetics), Viral Envelope Proteins (metabolism), Zoonoses.
- MESH :
- chemical , genetics : Viral Envelope Proteins.
- classification : Ebolavirus.
- epidemiology : Africa, Western, Hemorrhagic Fever, Ebola.
- genetics : Ebolavirus.
- chemical , metabolism : Viral Envelope Proteins.
- pathogenicity : Ebolavirus.
- physiology : Ebolavirus.
- transmission : Hemorrhagic Fever, Ebola.
- virology : Chiroptera, Hemorrhagic Fever, Ebola.
- Animals, Biological Evolution, Disease Outbreaks, Host Specificity, Humans, Mutation, Phylogeny, Zoonoses.
Abstract
The 2013-2016 outbreak of Ebola virus (EBOV) in West Africa was the largest recorded. It began following the cross-species transmission of EBOV from an animal reservoir, most likely bats, into humans, with phylogenetic analysis revealing the co-circulation of several viral lineages. We hypothesized that this prolonged human circulation led to genomic changes that increased viral transmissibility in humans. We generated a synthetic glycoprotein (GP) construct based on the earliest reported isolate and introduced amino acid substitutions that defined viral lineages. Mutant GPs were used to generate a panel of pseudoviruses, which were used to infect different human and bat cell lines. These data revealed that specific amino acid substitutions in the EBOV GP have increased tropism for human cells, while reducing tropism for bat cells. Such increased infectivity may have enhanced the ability of EBOV to transmit among humans and contributed to the wide geographic distribution of some viral lineages.
DOI: 10.1016/j.cell.2016.10.013
PubMed: 27814505
Links to Exploration step
pubmed:27814505Le document en format XML
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Urbanowicz</name><affiliation><nlm:affiliation>School of Life Sciences, The University of Nottingham, Nottingham NG7 2RD, UK; NIHR Nottingham Digestive Diseases Biomedical Research Unit, The University of Nottingham, Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Mcclure, C Patrick" sort="Mcclure, C Patrick" uniqKey="Mcclure C" first="C Patrick" last="Mcclure">C Patrick Mcclure</name><affiliation><nlm:affiliation>School of Life Sciences, The University of Nottingham, Nottingham NG7 2RD, UK; NIHR Nottingham Digestive Diseases Biomedical Research Unit, The University of Nottingham, Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Sakuntabhai, Anavaj" sort="Sakuntabhai, Anavaj" uniqKey="Sakuntabhai A" first="Anavaj" last="Sakuntabhai">Anavaj Sakuntabhai</name><affiliation><nlm:affiliation>Functional Genetics of Infectious Diseases Unit, Institut Pasteur, 75724 Paris Cedex 15, France; Centre National de la Recherche Scientifique, Unité de Recherche Associée 3012, 75015 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Sall, Amadou A" sort="Sall, Amadou A" uniqKey="Sall A" first="Amadou A" last="Sall">Amadou A. 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Ball</name><affiliation><nlm:affiliation>School of Life Sciences, The University of Nottingham, Nottingham NG7 2RD, UK; NIHR Nottingham Digestive Diseases Biomedical Research Unit, The University of Nottingham, Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, UK. Electronic address: jonathan.ball@nottingham.ac.uk.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27814505</idno><idno type="pmid">27814505</idno><idno type="doi">10.1016/j.cell.2016.10.013</idno><idno type="wicri:Area/PubMed/Corpus">001653</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001653</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Human Adaptation of Ebola Virus during the West African Outbreak.</title><author><name sortKey="Urbanowicz, Richard A" sort="Urbanowicz, Richard A" uniqKey="Urbanowicz R" first="Richard A" last="Urbanowicz">Richard A. Urbanowicz</name><affiliation><nlm:affiliation>School of Life Sciences, The University of Nottingham, Nottingham NG7 2RD, UK; NIHR Nottingham Digestive Diseases Biomedical Research Unit, The University of Nottingham, Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Mcclure, C Patrick" sort="Mcclure, C Patrick" uniqKey="Mcclure C" first="C Patrick" last="Mcclure">C Patrick Mcclure</name><affiliation><nlm:affiliation>School of Life Sciences, The University of Nottingham, Nottingham NG7 2RD, UK; NIHR Nottingham Digestive Diseases Biomedical Research Unit, The University of Nottingham, Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Sakuntabhai, Anavaj" sort="Sakuntabhai, Anavaj" uniqKey="Sakuntabhai A" first="Anavaj" last="Sakuntabhai">Anavaj Sakuntabhai</name><affiliation><nlm:affiliation>Functional Genetics of Infectious Diseases Unit, Institut Pasteur, 75724 Paris Cedex 15, France; Centre National de la Recherche Scientifique, Unité de Recherche Associée 3012, 75015 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Sall, Amadou A" sort="Sall, Amadou A" uniqKey="Sall A" first="Amadou A" last="Sall">Amadou A. Sall</name><affiliation><nlm:affiliation>Arbovirus and Viral Hemorrhagic Fever Unit, Institut Pasteur de Dakar, BP 220 Dakar, Senegal.</nlm:affiliation></affiliation></author><author><name sortKey="Kobinger, Gary" sort="Kobinger, Gary" uniqKey="Kobinger G" first="Gary" last="Kobinger">Gary Kobinger</name><affiliation><nlm:affiliation>Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Ottawa, ON K1A 0K9, Canada; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, MB R32T 2N2, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Muller, Marcel A" sort="Muller, Marcel A" uniqKey="Muller M" first="Marcel A" last="Müller">Marcel A. Müller</name><affiliation><nlm:affiliation>Institute of Virology, University of Bonn Medical Center, 53127 Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Holmes, Edward C" sort="Holmes, Edward C" uniqKey="Holmes E" first="Edward C" last="Holmes">Edward C. Holmes</name><affiliation><nlm:affiliation>Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2050, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Rey, Felix A" sort="Rey, Felix A" uniqKey="Rey F" first="Félix A" last="Rey">Félix A. Rey</name><affiliation><nlm:affiliation>Institut Pasteur, Département de Virologie, Unité de Virologie Structurale, 75724 Paris Cedex 15, France; Centre National de la Recherche Scientifique, Unité Mixte de Recherche 3569, 75724 Paris Cedex 15, France.</nlm:affiliation></affiliation></author><author><name sortKey="Simon Loriere, Etienne" sort="Simon Loriere, Etienne" uniqKey="Simon Loriere E" first="Etienne" last="Simon-Loriere">Etienne Simon-Loriere</name><affiliation><nlm:affiliation>Functional Genetics of Infectious Diseases Unit, Institut Pasteur, 75724 Paris Cedex 15, France; Centre National de la Recherche Scientifique, Unité de Recherche Associée 3012, 75015 Paris, France. Electronic address: etienne.simon-loriere@pasteur.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Ball, Jonathan K" sort="Ball, Jonathan K" uniqKey="Ball J" first="Jonathan K" last="Ball">Jonathan K. Ball</name><affiliation><nlm:affiliation>School of Life Sciences, The University of Nottingham, Nottingham NG7 2RD, UK; NIHR Nottingham Digestive Diseases Biomedical Research Unit, The University of Nottingham, Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, UK. Electronic address: jonathan.ball@nottingham.ac.uk.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Cell</title><idno type="eISSN">1097-4172</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Africa, Western (epidemiology)</term><term>Animals</term><term>Biological Evolution</term><term>Chiroptera (virology)</term><term>Disease Outbreaks</term><term>Ebolavirus (classification)</term><term>Ebolavirus (genetics)</term><term>Ebolavirus (pathogenicity)</term><term>Ebolavirus (physiology)</term><term>Hemorrhagic Fever, Ebola (epidemiology)</term><term>Hemorrhagic Fever, Ebola (transmission)</term><term>Hemorrhagic Fever, Ebola (virology)</term><term>Host Specificity</term><term>Humans</term><term>Mutation</term><term>Phylogeny</term><term>Viral Envelope Proteins (genetics)</term><term>Viral Envelope Proteins (metabolism)</term><term>Zoonoses</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Ebolavirus</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Africa, Western</term><term>Hemorrhagic Fever, Ebola</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Ebolavirus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Ebolavirus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Ebolavirus</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Hemorrhagic Fever, Ebola</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Chiroptera</term><term>Hemorrhagic Fever, Ebola</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Biological Evolution</term><term>Disease Outbreaks</term><term>Host Specificity</term><term>Humans</term><term>Mutation</term><term>Phylogeny</term><term>Zoonoses</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The 2013-2016 outbreak of Ebola virus (EBOV) in West Africa was the largest recorded. It began following the cross-species transmission of EBOV from an animal reservoir, most likely bats, into humans, with phylogenetic analysis revealing the co-circulation of several viral lineages. We hypothesized that this prolonged human circulation led to genomic changes that increased viral transmissibility in humans. We generated a synthetic glycoprotein (GP) construct based on the earliest reported isolate and introduced amino acid substitutions that defined viral lineages. Mutant GPs were used to generate a panel of pseudoviruses, which were used to infect different human and bat cell lines. These data revealed that specific amino acid substitutions in the EBOV GP have increased tropism for human cells, while reducing tropism for bat cells. Such increased infectivity may have enhanced the ability of EBOV to transmit among humans and contributed to the wide geographic distribution of some viral lineages.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27814505</PMID><DateCreated><Year>2016</Year><Month>11</Month><Day>04</Day></DateCreated><DateCompleted><Year>2017</Year><Month>04</Month><Day>04</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1097-4172</ISSN><JournalIssue CitedMedium="Internet"><Volume>167</Volume><Issue>4</Issue><PubDate><Year>2016</Year><Month>11</Month><Day>03</Day></PubDate></JournalIssue><Title>Cell</Title><ISOAbbreviation>Cell</ISOAbbreviation></Journal><ArticleTitle>Human Adaptation of Ebola Virus during the West African Outbreak.</ArticleTitle><Pagination><MedlinePgn>1079-1087.e5</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0092-8674(16)31396-4</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cell.2016.10.013</ELocationID><Abstract><AbstractText>The 2013-2016 outbreak of Ebola virus (EBOV) in West Africa was the largest recorded. It began following the cross-species transmission of EBOV from an animal reservoir, most likely bats, into humans, with phylogenetic analysis revealing the co-circulation of several viral lineages. We hypothesized that this prolonged human circulation led to genomic changes that increased viral transmissibility in humans. We generated a synthetic glycoprotein (GP) construct based on the earliest reported isolate and introduced amino acid substitutions that defined viral lineages. Mutant GPs were used to generate a panel of pseudoviruses, which were used to infect different human and bat cell lines. These data revealed that specific amino acid substitutions in the EBOV GP have increased tropism for human cells, while reducing tropism for bat cells. Such increased infectivity may have enhanced the ability of EBOV to transmit among humans and contributed to the wide geographic distribution of some viral lineages.</AbstractText><CopyrightInformation>Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Urbanowicz</LastName><ForeName>Richard A</ForeName><Initials>RA</Initials><AffiliationInfo><Affiliation>School of Life Sciences, The University of Nottingham, Nottingham NG7 2RD, UK; NIHR Nottingham Digestive Diseases Biomedical Research Unit, The University of Nottingham, Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McClure</LastName><ForeName>C Patrick</ForeName><Initials>CP</Initials><AffiliationInfo><Affiliation>School of Life Sciences, The University of Nottingham, Nottingham NG7 2RD, UK; NIHR Nottingham Digestive Diseases Biomedical Research Unit, The University of Nottingham, Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sakuntabhai</LastName><ForeName>Anavaj</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Functional Genetics of Infectious Diseases Unit, Institut Pasteur, 75724 Paris Cedex 15, France; Centre National de la Recherche Scientifique, Unité de Recherche Associée 3012, 75015 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sall</LastName><ForeName>Amadou A</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>Arbovirus and Viral Hemorrhagic Fever Unit, Institut Pasteur de Dakar, BP 220 Dakar, Senegal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kobinger</LastName><ForeName>Gary</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Ottawa, ON K1A 0K9, Canada; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, MB R32T 2N2, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Müller</LastName><ForeName>Marcel A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Institute of Virology, University of Bonn Medical Center, 53127 Bonn, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holmes</LastName><ForeName>Edward C</ForeName><Initials>EC</Initials><AffiliationInfo><Affiliation>Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2050, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rey</LastName><ForeName>Félix A</ForeName><Initials>FA</Initials><AffiliationInfo><Affiliation>Institut Pasteur, Département de Virologie, Unité de Virologie Structurale, 75724 Paris Cedex 15, France; Centre National de la Recherche Scientifique, Unité Mixte de Recherche 3569, 75724 Paris Cedex 15, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simon-Loriere</LastName><ForeName>Etienne</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Functional Genetics of Infectious Diseases Unit, Institut Pasteur, 75724 Paris Cedex 15, France; Centre National de la Recherche Scientifique, Unité de Recherche Associée 3012, 75015 Paris, France. Electronic address: etienne.simon-loriere@pasteur.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ball</LastName><ForeName>Jonathan K</ForeName><Initials>JK</Initials><AffiliationInfo><Affiliation>School of Life Sciences, The University of Nottingham, Nottingham NG7 2RD, UK; NIHR Nottingham Digestive Diseases Biomedical Research Unit, The University of Nottingham, Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, UK. Electronic address: jonathan.ball@nottingham.ac.uk.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>G0801169</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cell</MedlineTA><NlmUniqueID>0413066</NlmUniqueID><ISSNLinking>0092-8674</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014759">Viral Envelope Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C113189">envelope glycoprotein, Ebola 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PubStatus="entrez"><Year>2016</Year><Month>11</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>11</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>4</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27814505</ArticleId><ArticleId IdType="pii">S0092-8674(16)31396-4</ArticleId><ArticleId IdType="doi">10.1016/j.cell.2016.10.013</ArticleId><ArticleId IdType="pmc">PMC5101188</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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