Effects of liver-stage clearance by Primaquine on gametocyte carriage of Plasmodium vivax and P. falciparum.
Identifieur interne : 000949 ( PubMed/Corpus ); précédent : 000948; suivant : 000950Effects of liver-stage clearance by Primaquine on gametocyte carriage of Plasmodium vivax and P. falciparum.
Auteurs : Rahel Wampfler ; Natalie E. Hofmann ; Stephan Karl ; Inoni Betuela ; Benson Kinboro ; Lina Lorry ; Mariabeth Silkey ; Leanne J. Robinson ; Ivo Mueller ; Ingrid FelgerSource :
- PLoS neglected tropical diseases [ 1935-2735 ] ; 2017.
English descriptors
- KwdEn :
- Antimalarials (therapeutic use), Artemisinins (therapeutic use), Blood (parasitology), Child, Child, Preschool, Chloroquine (therapeutic use), Double-Blind Method, Drug Combinations, Ethanolamines (therapeutic use), Female, Fluorenes (therapeutic use), Humans, Liver (drug effects), Liver (parasitology), Malaria, Falciparum (drug therapy), Malaria, Vivax (drug therapy), Male, Multivariate Analysis, Papua New Guinea, Plasmodium falciparum (drug effects), Plasmodium vivax (drug effects), Primaquine (therapeutic use), Recurrence, Regression Analysis, Risk Factors.
- MESH :
- chemical , therapeutic use : Antimalarials, Artemisinins, Chloroquine, Ethanolamines, Fluorenes, Primaquine.
- drug effects : Liver, Plasmodium falciparum, Plasmodium vivax.
- drug therapy : Malaria, Falciparum, Malaria, Vivax.
- parasitology : Blood, Liver.
- Child, Child, Preschool, Double-Blind Method, Drug Combinations, Female, Humans, Male, Multivariate Analysis, Papua New Guinea, Recurrence, Regression Analysis, Risk Factors.
Abstract
Primaquine (PQ) is the only currently licensed antimalarial that prevents Plasmodium vivax (Pv) relapses. It also clears mature P. falciparum (Pf) gametocytes, thereby reducing post-treatment transmission. Randomized PQ treatment in a treatment-to-reinfection cohort in Papua New Guinean children permitted the study of Pv and Pf gametocyte carriage after radical cure and to investigate the contribution of Pv relapses.
DOI: 10.1371/journal.pntd.0005753
PubMed: 28732068
Links to Exploration step
pubmed:28732068Le document en format XML
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<term>Blood (parasitology)</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Chloroquine (therapeutic use)</term>
<term>Double-Blind Method</term>
<term>Drug Combinations</term>
<term>Ethanolamines (therapeutic use)</term>
<term>Female</term>
<term>Fluorenes (therapeutic use)</term>
<term>Humans</term>
<term>Liver (drug effects)</term>
<term>Liver (parasitology)</term>
<term>Malaria, Falciparum (drug therapy)</term>
<term>Malaria, Vivax (drug therapy)</term>
<term>Male</term>
<term>Multivariate Analysis</term>
<term>Papua New Guinea</term>
<term>Plasmodium falciparum (drug effects)</term>
<term>Plasmodium vivax (drug effects)</term>
<term>Primaquine (therapeutic use)</term>
<term>Recurrence</term>
<term>Regression Analysis</term>
<term>Risk Factors</term>
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<term>Chloroquine</term>
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<term>Fluorenes</term>
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<term>Plasmodium falciparum</term>
<term>Plasmodium vivax</term>
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<front><div type="abstract" xml:lang="en">Primaquine (PQ) is the only currently licensed antimalarial that prevents Plasmodium vivax (Pv) relapses. It also clears mature P. falciparum (Pf) gametocytes, thereby reducing post-treatment transmission. Randomized PQ treatment in a treatment-to-reinfection cohort in Papua New Guinean children permitted the study of Pv and Pf gametocyte carriage after radical cure and to investigate the contribution of Pv relapses.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28732068</PMID>
<DateCreated><Year>2017</Year>
<Month>07</Month>
<Day>21</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>08</Month>
<Day>10</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>08</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1935-2735</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>11</Volume>
<Issue>7</Issue>
<PubDate><Year>2017</Year>
<Month>Jul</Month>
</PubDate>
</JournalIssue>
<Title>PLoS neglected tropical diseases</Title>
<ISOAbbreviation>PLoS Negl Trop Dis</ISOAbbreviation>
</Journal>
<ArticleTitle>Effects of liver-stage clearance by Primaquine on gametocyte carriage of Plasmodium vivax and P. falciparum.</ArticleTitle>
<Pagination><MedlinePgn>e0005753</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pntd.0005753</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Primaquine (PQ) is the only currently licensed antimalarial that prevents Plasmodium vivax (Pv) relapses. It also clears mature P. falciparum (Pf) gametocytes, thereby reducing post-treatment transmission. Randomized PQ treatment in a treatment-to-reinfection cohort in Papua New Guinean children permitted the study of Pv and Pf gametocyte carriage after radical cure and to investigate the contribution of Pv relapses.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Children received radical cure with Chloroquine, Artemether-Lumefantrine plus either PQ or placebo. Blood samples were subsequently collected in 2-to 4-weekly intervals over 8 months. Gametocytes were detected by quantitative reverse transcription-PCR targeting pvs25 and pfs25.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">PQ treatment reduced the incidence of Pv gametocytes by 73%, which was comparable to the effect of PQ on incidence of blood-stage infections. 92% of Pv and 79% of Pf gametocyte-positive infections were asymptomatic. Pv and to a lesser extent Pf gametocyte positivity and density were associated with high blood-stage parasite densities. Multivariate analysis revealed that the odds of gametocytes were significantly reduced in mixed-species infections compared to single-species infections for both species (ORPv = 0.39 [95% CI 0.25-0.62], ORPf = 0.33 [95% CI 0.18-0.60], p<0.001). No difference between the PQ and placebo treatment arms was observed in density of Pv gametocytes or in the proportion of Pv infections that carried gametocytes. First infections after blood-stage and placebo treatment, likely caused by a relapsing hypnozoite, were equally likely to carry gametocytes than first infections after PQ treatment, likely caused by an infective mosquito bite.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Pv relapses and new infections are associated with similar levels of gametocytaemia. Relapses thus contribute considerably to the Pv reservoir highlighting the importance of effective anti-hypnozoite treatment for efficient control of Pv.</AbstractText>
<AbstractText Label="TRIAL REGISTRATION" NlmCategory="BACKGROUND">ClinicalTrials.gov NCT02143934.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wampfler</LastName>
<ForeName>Rahel</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>University of Basel, Basel, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hofmann</LastName>
<ForeName>Natalie E</ForeName>
<Initials>NE</Initials>
<AffiliationInfo><Affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>University of Basel, Basel, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Karl</LastName>
<ForeName>Stephan</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Divison of Population Health and Immunity, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Betuela</LastName>
<ForeName>Inoni</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Vector Borne Diseases Unit, PNG Institute of Medical Research, Goroka, Papua New Guinea.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Kinboro</LastName>
<ForeName>Benson</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Vector Borne Diseases Unit, PNG Institute of Medical Research, Goroka, Papua New Guinea.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Lorry</LastName>
<ForeName>Lina</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Vector Borne Diseases Unit, PNG Institute of Medical Research, Goroka, Papua New Guinea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Silkey</LastName>
<ForeName>Mariabeth</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Robinson</LastName>
<ForeName>Leanne J</ForeName>
<Initials>LJ</Initials>
<AffiliationInfo><Affiliation>Divison of Population Health and Immunity, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Victoria, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Vector Borne Diseases Unit, PNG Institute of Medical Research, Goroka, Papua New Guinea.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Centre for Biomedical Research, Burnet Institute, Melbourne, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mueller</LastName>
<ForeName>Ivo</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Divison of Population Health and Immunity, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Victoria, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Malaria Parasites & Hosts Unit, Institut Pasteur, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Felger</LastName>
<ForeName>Ingrid</ForeName>
<Initials>I</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0003-1255-2606</Identifier>
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<AffiliationInfo><Affiliation>University of Basel, Basel, Switzerland.</Affiliation>
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