TFOS DEWS II pathophysiology report.
Identifieur interne : 000947 ( PubMed/Corpus ); précédent : 000946; suivant : 000948TFOS DEWS II pathophysiology report.
Auteurs : Anthony J. Bron ; Cintia S. De Paiva ; Sunil K. Chauhan ; Stefano Bonini ; Eric E. Gabison ; Sandeep Jain ; Erich Knop ; Maria Markoulli ; Yoko Ogawa ; Victor Perez ; Yuichi Uchino ; Norihiko Yokoi ; Driss Zoukhri ; David A. SullivanSource :
- The ocular surface [ 1937-5913 ] ; 2017.
Abstract
The TFOS DEWS II Pathophysiology Subcommittee reviewed the mechanisms involved in the initiation and perpetuation of dry eye disease. Its central mechanism is evaporative water loss leading to hyperosmolar tissue damage. Research in human disease and in animal models has shown that this, either directly or by inducing inflammation, causes a loss of both epithelial and goblet cells. The consequent decrease in surface wettability leads to early tear film breakup and amplifies hyperosmolarity via a Vicious Circle. Pain in dry eye is caused by tear hyperosmolarity, loss of lubrication, inflammatory mediators and neurosensory factors, while visual symptoms arise from tear and ocular surface irregularity. Increased friction targets damage to the lids and ocular surface, resulting in characteristic punctate epithelial keratitis, superior limbic keratoconjunctivitis, filamentary keratitis, lid parallel conjunctival folds, and lid wiper epitheliopathy. Hybrid dry eye disease, with features of both aqueous deficiency and increased evaporation, is common and efforts should be made to determine the relative contribution of each form to the total picture. To this end, practical methods are needed to measure tear evaporation in the clinic, and similarly, methods are needed to measure osmolarity at the tissue level across the ocular surface, to better determine the severity of dry eye. Areas for future research include the role of genetic mechanisms in non-Sjögren syndrome dry eye, the targeting of the terminal duct in meibomian gland disease and the influence of gaze dynamics and the closed eye state on tear stability and ocular surface inflammation.
DOI: 10.1016/j.jtos.2017.05.011
PubMed: 28736340
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Chauhan</name><affiliation><nlm:affiliation>Schepens Eye Research Institute & Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bonini, Stefano" sort="Bonini, Stefano" uniqKey="Bonini S" first="Stefano" last="Bonini">Stefano Bonini</name><affiliation><nlm:affiliation>Department of Ophthalmology, University Campus Biomedico, Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Gabison, Eric E" sort="Gabison, Eric E" uniqKey="Gabison E" first="Eric E" last="Gabison">Eric E. Gabison</name><affiliation><nlm:affiliation>Department of Ophthalmology, Fondation Ophtalmologique Rothschild & Hôpital Bichat Claude Bernard, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Jain, Sandeep" sort="Jain, Sandeep" uniqKey="Jain S" first="Sandeep" last="Jain">Sandeep Jain</name><affiliation><nlm:affiliation>Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Knop, Erich" sort="Knop, Erich" uniqKey="Knop E" first="Erich" last="Knop">Erich Knop</name><affiliation><nlm:affiliation>Departments of Cell and Neurobiology and Ocular Surface Center Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Markoulli, Maria" sort="Markoulli, Maria" uniqKey="Markoulli M" first="Maria" last="Markoulli">Maria Markoulli</name><affiliation><nlm:affiliation>School of Optometry and Vision Science, University of New South Wales, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Ogawa, Yoko" sort="Ogawa, Yoko" uniqKey="Ogawa Y" first="Yoko" last="Ogawa">Yoko Ogawa</name><affiliation><nlm:affiliation>Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Perez, Victor" sort="Perez, Victor" uniqKey="Perez V" first="Victor" last="Perez">Victor Perez</name><affiliation><nlm:affiliation>Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Uchino, Yuichi" sort="Uchino, Yuichi" uniqKey="Uchino Y" first="Yuichi" last="Uchino">Yuichi Uchino</name><affiliation><nlm:affiliation>Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Yokoi, Norihiko" sort="Yokoi, Norihiko" uniqKey="Yokoi N" first="Norihiko" last="Yokoi">Norihiko Yokoi</name><affiliation><nlm:affiliation>Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Zoukhri, Driss" sort="Zoukhri, Driss" uniqKey="Zoukhri D" first="Driss" last="Zoukhri">Driss Zoukhri</name><affiliation><nlm:affiliation>Tufts University School of Dental Medicine, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Sullivan, David A" sort="Sullivan, David A" uniqKey="Sullivan D" first="David A" last="Sullivan">David A. Sullivan</name><affiliation><nlm:affiliation>Schepens Eye Research Institute & Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28736340</idno><idno type="pmid">28736340</idno><idno type="doi">10.1016/j.jtos.2017.05.011</idno><idno type="wicri:Area/PubMed/Corpus">000947</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000947</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">TFOS DEWS II pathophysiology report.</title><author><name sortKey="Bron, Anthony J" sort="Bron, Anthony J" uniqKey="Bron A" first="Anthony J" last="Bron">Anthony J. Bron</name><affiliation><nlm:affiliation>Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Vision and Eye Research Unit, Anglia Ruskin University, Cambridge, UK. Electronic address: anthony.bron@eye.ox.ac.uk.</nlm:affiliation></affiliation></author><author><name sortKey="De Paiva, Cintia S" sort="De Paiva, Cintia S" uniqKey="De Paiva C" first="Cintia S" last="De Paiva">Cintia S. De Paiva</name><affiliation><nlm:affiliation>Department of Ophthalmology, Baylor College of Medicine, Houston, TX, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chauhan, Sunil K" sort="Chauhan, Sunil K" uniqKey="Chauhan S" first="Sunil K" last="Chauhan">Sunil K. Chauhan</name><affiliation><nlm:affiliation>Schepens Eye Research Institute & Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bonini, Stefano" sort="Bonini, Stefano" uniqKey="Bonini S" first="Stefano" last="Bonini">Stefano Bonini</name><affiliation><nlm:affiliation>Department of Ophthalmology, University Campus Biomedico, Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Gabison, Eric E" sort="Gabison, Eric E" uniqKey="Gabison E" first="Eric E" last="Gabison">Eric E. Gabison</name><affiliation><nlm:affiliation>Department of Ophthalmology, Fondation Ophtalmologique Rothschild & Hôpital Bichat Claude Bernard, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Jain, Sandeep" sort="Jain, Sandeep" uniqKey="Jain S" first="Sandeep" last="Jain">Sandeep Jain</name><affiliation><nlm:affiliation>Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Knop, Erich" sort="Knop, Erich" uniqKey="Knop E" first="Erich" last="Knop">Erich Knop</name><affiliation><nlm:affiliation>Departments of Cell and Neurobiology and Ocular Surface Center Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Markoulli, Maria" sort="Markoulli, Maria" uniqKey="Markoulli M" first="Maria" last="Markoulli">Maria Markoulli</name><affiliation><nlm:affiliation>School of Optometry and Vision Science, University of New South Wales, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Ogawa, Yoko" sort="Ogawa, Yoko" uniqKey="Ogawa Y" first="Yoko" last="Ogawa">Yoko Ogawa</name><affiliation><nlm:affiliation>Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Perez, Victor" sort="Perez, Victor" uniqKey="Perez V" first="Victor" last="Perez">Victor Perez</name><affiliation><nlm:affiliation>Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Uchino, Yuichi" sort="Uchino, Yuichi" uniqKey="Uchino Y" first="Yuichi" last="Uchino">Yuichi Uchino</name><affiliation><nlm:affiliation>Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Yokoi, Norihiko" sort="Yokoi, Norihiko" uniqKey="Yokoi N" first="Norihiko" last="Yokoi">Norihiko Yokoi</name><affiliation><nlm:affiliation>Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Zoukhri, Driss" sort="Zoukhri, Driss" uniqKey="Zoukhri D" first="Driss" last="Zoukhri">Driss Zoukhri</name><affiliation><nlm:affiliation>Tufts University School of Dental Medicine, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Sullivan, David A" sort="Sullivan, David A" uniqKey="Sullivan D" first="David A" last="Sullivan">David A. Sullivan</name><affiliation><nlm:affiliation>Schepens Eye Research Institute & Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.</nlm:affiliation></affiliation></author></analytic><series><title level="j">The ocular surface</title><idno type="eISSN">1937-5913</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The TFOS DEWS II Pathophysiology Subcommittee reviewed the mechanisms involved in the initiation and perpetuation of dry eye disease. Its central mechanism is evaporative water loss leading to hyperosmolar tissue damage. Research in human disease and in animal models has shown that this, either directly or by inducing inflammation, causes a loss of both epithelial and goblet cells. The consequent decrease in surface wettability leads to early tear film breakup and amplifies hyperosmolarity via a Vicious Circle. Pain in dry eye is caused by tear hyperosmolarity, loss of lubrication, inflammatory mediators and neurosensory factors, while visual symptoms arise from tear and ocular surface irregularity. Increased friction targets damage to the lids and ocular surface, resulting in characteristic punctate epithelial keratitis, superior limbic keratoconjunctivitis, filamentary keratitis, lid parallel conjunctival folds, and lid wiper epitheliopathy. Hybrid dry eye disease, with features of both aqueous deficiency and increased evaporation, is common and efforts should be made to determine the relative contribution of each form to the total picture. To this end, practical methods are needed to measure tear evaporation in the clinic, and similarly, methods are needed to measure osmolarity at the tissue level across the ocular surface, to better determine the severity of dry eye. Areas for future research include the role of genetic mechanisms in non-Sjögren syndrome dry eye, the targeting of the terminal duct in meibomian gland disease and the influence of gaze dynamics and the closed eye state on tear stability and ocular surface inflammation.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28736340</PMID><DateCreated><Year>2017</Year><Month>07</Month><Day>24</Day></DateCreated><DateRevised><Year>2017</Year><Month>08</Month><Day>24</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1937-5913</ISSN><JournalIssue CitedMedium="Internet"><Volume>15</Volume><Issue>3</Issue><PubDate><Year>2017</Year><Month>Jul</Month></PubDate></JournalIssue><Title>The ocular surface</Title><ISOAbbreviation>Ocul Surf</ISOAbbreviation></Journal><ArticleTitle>TFOS DEWS II pathophysiology report.</ArticleTitle><Pagination><MedlinePgn>438-510</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1542-0124(17)30134-9</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jtos.2017.05.011</ELocationID><Abstract><AbstractText>The TFOS DEWS II Pathophysiology Subcommittee reviewed the mechanisms involved in the initiation and perpetuation of dry eye disease. Its central mechanism is evaporative water loss leading to hyperosmolar tissue damage. Research in human disease and in animal models has shown that this, either directly or by inducing inflammation, causes a loss of both epithelial and goblet cells. The consequent decrease in surface wettability leads to early tear film breakup and amplifies hyperosmolarity via a Vicious Circle. Pain in dry eye is caused by tear hyperosmolarity, loss of lubrication, inflammatory mediators and neurosensory factors, while visual symptoms arise from tear and ocular surface irregularity. Increased friction targets damage to the lids and ocular surface, resulting in characteristic punctate epithelial keratitis, superior limbic keratoconjunctivitis, filamentary keratitis, lid parallel conjunctival folds, and lid wiper epitheliopathy. Hybrid dry eye disease, with features of both aqueous deficiency and increased evaporation, is common and efforts should be made to determine the relative contribution of each form to the total picture. To this end, practical methods are needed to measure tear evaporation in the clinic, and similarly, methods are needed to measure osmolarity at the tissue level across the ocular surface, to better determine the severity of dry eye. Areas for future research include the role of genetic mechanisms in non-Sjögren syndrome dry eye, the targeting of the terminal duct in meibomian gland disease and the influence of gaze dynamics and the closed eye state on tear stability and ocular surface inflammation.</AbstractText><CopyrightInformation>Copyright © 2017 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bron</LastName><ForeName>Anthony J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Vision and Eye Research Unit, Anglia Ruskin University, Cambridge, UK. Electronic address: anthony.bron@eye.ox.ac.uk.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Paiva</LastName><ForeName>Cintia S</ForeName><Initials>CS</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Baylor College of Medicine, Houston, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chauhan</LastName><ForeName>Sunil K</ForeName><Initials>SK</Initials><AffiliationInfo><Affiliation>Schepens Eye Research Institute & Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bonini</LastName><ForeName>Stefano</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, University Campus Biomedico, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gabison</LastName><ForeName>Eric E</ForeName><Initials>EE</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Fondation Ophtalmologique Rothschild & Hôpital Bichat Claude Bernard, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jain</LastName><ForeName>Sandeep</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Knop</LastName><ForeName>Erich</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Departments of Cell and Neurobiology and Ocular Surface Center Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Markoulli</LastName><ForeName>Maria</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>School of Optometry and Vision Science, University of New South Wales, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ogawa</LastName><ForeName>Yoko</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perez</LastName><ForeName>Victor</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Uchino</LastName><ForeName>Yuichi</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yokoi</LastName><ForeName>Norihiko</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zoukhri</LastName><ForeName>Driss</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Tufts University School of Dental Medicine, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sullivan</LastName><ForeName>David A</ForeName><Initials>DA</Initials><AffiliationInfo><Affiliation>Schepens Eye Research Institute & Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 EY012383</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>07</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Ocul Surf</MedlineTA><NlmUniqueID>101156063</NlmUniqueID><ISSNLinking>1542-0124</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">DEWS II</Keyword><Keyword MajorTopicYN="N">Dry eye disease</Keyword><Keyword MajorTopicYN="N">Dry eye workshop</Keyword><Keyword MajorTopicYN="N">Glycocalyx</Keyword><Keyword MajorTopicYN="N">Hyperosmolarity</Keyword><Keyword MajorTopicYN="N">Inflammation</Keyword><Keyword MajorTopicYN="N">Pathophysiology</Keyword><Keyword MajorTopicYN="N">TFOS</Keyword><Keyword MajorTopicYN="N">Vicious circle</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>05</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>05</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>7</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>7</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>7</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28736340</ArticleId><ArticleId IdType="pii">S1542-0124(17)30134-9</ArticleId><ArticleId IdType="doi">10.1016/j.jtos.2017.05.011</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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