No evidence for toxicity after long-term photobiomodulation in normal non-human primates.
Identifieur interne : 000944 ( PubMed/Corpus ); précédent : 000943; suivant : 000945No evidence for toxicity after long-term photobiomodulation in normal non-human primates.
Auteurs : Cécile Moro ; Napoleon Torres ; Katerina Arvanitakis ; Karen Cullen ; Claude Chabrol ; Diane Agay ; Fannie Darlot ; Alim-Louis Benabid ; John MitrofanisSource :
- Experimental brain research [ 1432-1106 ] ; 2017.
Abstract
In this study, we explored the effects of a longer term application, up to 12 weeks, of photobiomodulation in normal, naïve macaque monkeys. Monkeys (n = 5) were implanted intracranially with an optical fibre device delivering photobiomodulation (red light, 670 nm) to a midline midbrain region. Animals were then aldehyde-fixed and their brains were processed for immunohistochemistry. In general, our results showed that longer term intracranial application of photobiomodulation had no adverse effects on the surrounding brain parenchyma or on the nearby dopaminergic cell system. We found no evidence for photobiomodulation generating an inflammatory glial response or neuronal degeneration near the implant site; further, photobiomodulation did not induce an abnormal activation or mitochondrial stress in nearby cells, nor did it cause an abnormal arrangement of the surrounding vasculature (endothelial basement membrane). Finally, because of our interest in Parkinson's disease, we noted that photobiomodulation had no impact on the number of midbrain dopaminergic cells and the density of their terminations in the striatum. In summary, we found no histological basis for any major biosafety concerns associated with photobiomodulation delivered by our intracranial approach and our findings set a key template for progress onto clinical trial on patients with Parkinson's disease.
DOI: 10.1007/s00221-017-5048-7
PubMed: 28744621
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2006, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Cullen, Karen" sort="Cullen, Karen" uniqKey="Cullen K" first="Karen" last="Cullen">Karen Cullen</name><affiliation><nlm:affiliation>Department of Anatomy F13, University of Sydney, Camperdown, 2006, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Chabrol, Claude" sort="Chabrol, Claude" uniqKey="Chabrol C" first="Claude" last="Chabrol">Claude Chabrol</name><affiliation><nlm:affiliation>University of Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Agay, Diane" sort="Agay, Diane" uniqKey="Agay D" first="Diane" last="Agay">Diane Agay</name><affiliation><nlm:affiliation>University of Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Darlot, Fannie" sort="Darlot, Fannie" uniqKey="Darlot F" first="Fannie" last="Darlot">Fannie Darlot</name><affiliation><nlm:affiliation>University of Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><affiliation><nlm:affiliation>University of Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Mitrofanis, John" sort="Mitrofanis, John" uniqKey="Mitrofanis J" first="John" last="Mitrofanis">John Mitrofanis</name><affiliation><nlm:affiliation>Department of Anatomy F13, University of Sydney, Camperdown, 2006, Australia. john.mitrofanis@sydney.edu.au.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28744621</idno><idno 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sortKey="Arvanitakis, Katerina" sort="Arvanitakis, Katerina" uniqKey="Arvanitakis K" first="Katerina" last="Arvanitakis">Katerina Arvanitakis</name><affiliation><nlm:affiliation>Department of Anatomy F13, University of Sydney, Camperdown, 2006, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Cullen, Karen" sort="Cullen, Karen" uniqKey="Cullen K" first="Karen" last="Cullen">Karen Cullen</name><affiliation><nlm:affiliation>Department of Anatomy F13, University of Sydney, Camperdown, 2006, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Chabrol, Claude" sort="Chabrol, Claude" uniqKey="Chabrol C" first="Claude" last="Chabrol">Claude Chabrol</name><affiliation><nlm:affiliation>University of Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Agay, Diane" sort="Agay, Diane" uniqKey="Agay D" first="Diane" last="Agay">Diane Agay</name><affiliation><nlm:affiliation>University of Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Darlot, Fannie" sort="Darlot, Fannie" uniqKey="Darlot F" first="Fannie" last="Darlot">Fannie Darlot</name><affiliation><nlm:affiliation>University of Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><affiliation><nlm:affiliation>University of Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Mitrofanis, John" sort="Mitrofanis, John" uniqKey="Mitrofanis J" first="John" last="Mitrofanis">John Mitrofanis</name><affiliation><nlm:affiliation>Department of Anatomy F13, University of Sydney, Camperdown, 2006, Australia. john.mitrofanis@sydney.edu.au.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Experimental brain research</title><idno type="eISSN">1432-1106</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In this study, we explored the effects of a longer term application, up to 12 weeks, of photobiomodulation in normal, naïve macaque monkeys. Monkeys (n = 5) were implanted intracranially with an optical fibre device delivering photobiomodulation (red light, 670 nm) to a midline midbrain region. Animals were then aldehyde-fixed and their brains were processed for immunohistochemistry. In general, our results showed that longer term intracranial application of photobiomodulation had no adverse effects on the surrounding brain parenchyma or on the nearby dopaminergic cell system. We found no evidence for photobiomodulation generating an inflammatory glial response or neuronal degeneration near the implant site; further, photobiomodulation did not induce an abnormal activation or mitochondrial stress in nearby cells, nor did it cause an abnormal arrangement of the surrounding vasculature (endothelial basement membrane). Finally, because of our interest in Parkinson's disease, we noted that photobiomodulation had no impact on the number of midbrain dopaminergic cells and the density of their terminations in the striatum. In summary, we found no histological basis for any major biosafety concerns associated with photobiomodulation delivered by our intracranial approach and our findings set a key template for progress onto clinical trial on patients with Parkinson's disease.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">28744621</PMID><DateCreated><Year>2017</Year><Month>07</Month><Day>26</Day></DateCreated><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-1106</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2017</Year><Month>Jul</Month><Day>25</Day></PubDate></JournalIssue><Title>Experimental brain research</Title><ISOAbbreviation>Exp Brain Res</ISOAbbreviation></Journal><ArticleTitle>No evidence for toxicity after long-term photobiomodulation in normal non-human primates.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00221-017-5048-7</ELocationID><Abstract><AbstractText>In this study, we explored the effects of a longer term application, up to 12 weeks, of photobiomodulation in normal, naïve macaque monkeys. Monkeys (n = 5) were implanted intracranially with an optical fibre device delivering photobiomodulation (red light, 670 nm) to a midline midbrain region. Animals were then aldehyde-fixed and their brains were processed for immunohistochemistry. In general, our results showed that longer term intracranial application of photobiomodulation had no adverse effects on the surrounding brain parenchyma or on the nearby dopaminergic cell system. We found no evidence for photobiomodulation generating an inflammatory glial response or neuronal degeneration near the implant site; further, photobiomodulation did not induce an abnormal activation or mitochondrial stress in nearby cells, nor did it cause an abnormal arrangement of the surrounding vasculature (endothelial basement membrane). Finally, because of our interest in Parkinson's disease, we noted that photobiomodulation had no impact on the number of midbrain dopaminergic cells and the density of their terminations in the striatum. In summary, we found no histological basis for any major biosafety concerns associated with photobiomodulation delivered by our intracranial approach and our findings set a key template for progress onto clinical trial on patients with Parkinson's disease.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Moro</LastName><ForeName>Cécile</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>University of Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Torres</LastName><ForeName>Napoleon</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>University of Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arvanitakis</LastName><ForeName>Katerina</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Anatomy F13, University of Sydney, Camperdown, 2006, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cullen</LastName><ForeName>Karen</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Anatomy F13, University of Sydney, Camperdown, 2006, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chabrol</LastName><ForeName>Claude</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>University of Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Agay</LastName><ForeName>Diane</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>University of Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Darlot</LastName><ForeName>Fannie</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>University of Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Benabid</LastName><ForeName>Alim-Louis</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>University of Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mitrofanis</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Anatomy F13, University of Sydney, Camperdown, 2006, Australia. john.mitrofanis@sydney.edu.au.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>07</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Exp Brain 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