Associations Between Retinal Pigment Epithelium and Drusen Volume Changes During the Lifecycle of Large Drusenoid Pigment Epithelial Detachments.
Identifieur interne : 002288 ( PubMed/Checkpoint ); précédent : 002287; suivant : 002289Associations Between Retinal Pigment Epithelium and Drusen Volume Changes During the Lifecycle of Large Drusenoid Pigment Epithelial Detachments.
Auteurs : Chandrakumar Balaratnasingam [Australie] ; Lawrence A. Yannuzzi [États-Unis] ; Christine A. Curcio [États-Unis] ; William H. Morgan [États-Unis] ; Giuseppe Querques [Italie] ; Vittorio Capuano [France] ; Eric Souied [Italie] ; Jesse Jung [États-Unis] ; K Bailey Freund [États-Unis]Source :
- Investigative ophthalmology & visual science [ 1552-5783 ] ; 2016.
Descripteurs français
- KwdFr :
- Acuité visuelle, Adulte d'âge moyen, Angiographie fluorescéinique, Druses de la rétine (), Druses de la rétine (diagnostic), Décollement de la rétine (diagnostic), Décollement de la rétine (étiologie), Facteurs temps, Femelle, Fond de l'oeil, Humains, Mâle, Pronostic, Sujet âgé, Sujet âgé de 80 ans ou plus, Tomographie par cohérence optique (), Épithélium pigmentaire de la rétine (anatomopathologie), Études de suivi, Études rétrospectives, Évolution de la maladie.
- MESH :
- anatomopathologie : Épithélium pigmentaire de la rétine.
- diagnostic : Druses de la rétine, Décollement de la rétine.
- étiologie : Décollement de la rétine.
- Acuité visuelle, Adulte d'âge moyen, Angiographie fluorescéinique, Druses de la rétine, Facteurs temps, Femelle, Fond de l'oeil, Humains, Mâle, Pronostic, Sujet âgé, Sujet âgé de 80 ans ou plus, Tomographie par cohérence optique, Études de suivi, Études rétrospectives, Évolution de la maladie.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Disease Progression, Female, Fluorescein Angiography, Follow-Up Studies, Fundus Oculi, Humans, Male, Middle Aged, Prognosis, Retinal Detachment (diagnosis), Retinal Detachment (etiology), Retinal Drusen (complications), Retinal Drusen (diagnosis), Retinal Pigment Epithelium (pathology), Retrospective Studies, Time Factors, Tomography, Optical Coherence (methods), Visual Acuity.
- MESH :
- complications : Retinal Drusen.
- diagnosis : Retinal Detachment, Retinal Drusen.
- etiology : Retinal Detachment.
- methods : Tomography, Optical Coherence.
- pathology : Retinal Pigment Epithelium.
- Aged, Aged, 80 and over, Disease Progression, Female, Fluorescein Angiography, Follow-Up Studies, Fundus Oculi, Humans, Male, Middle Aged, Prognosis, Retrospective Studies, Time Factors, Visual Acuity.
Abstract
Drusenoid pigment epithelial detachments (PEDs) are a defined path to atrophy in age-related macular degeneration (AMD). We analyzed the relationships between retinal pigment epithelium (RPE) and drusen volume changes during the PED lifecycle, using spectral-domain optical coherence tomography (SD-OCT).
DOI: 10.1167/iovs.16-19816
PubMed: 27760262
Affiliations:
- Australie, France, Italie, États-Unis
- Alabama, Californie, Lombardie, État de New York, Île-de-France
- Créteil, Milan
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pubmed:27760262Le document en format XML
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Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, United States 2Vitreous-Retina-Macula Consultants of New York, New York, United States 3Department of Ophthalmology, New York University School of Medicine, New York, New York, United States 4Department of Physiology and Pharmacology, Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, United States 2Vitreous-Retina-Macula Consultants of New York, New York, United States 3Department of Ophthalmology, New York University School of Medicine, New York, New York, United States 4Department of Physiology and Pharmacology, Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth</wicri:regionArea><wicri:noRegion>Perth</wicri:noRegion></affiliation></author><author><name sortKey="Yannuzzi, Lawrence A" sort="Yannuzzi, Lawrence A" uniqKey="Yannuzzi L" first="Lawrence A" last="Yannuzzi">Lawrence A. Yannuzzi</name><affiliation wicri:level="2"><nlm:affiliation>LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, United States 2Vitreous-Retina-Macula Consultants of New York, New York, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, United States 2Vitreous-Retina-Macula Consultants of New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Curcio, Christine A" sort="Curcio, Christine A" uniqKey="Curcio C" first="Christine A" last="Curcio">Christine A. Curcio</name><affiliation wicri:level="2"><nlm:affiliation>Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, Alabama, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, Alabama</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Morgan, William H" sort="Morgan, William H" uniqKey="Morgan W" first="William H" last="Morgan">William H. 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Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, United States 2Vitreous-Retina-Macula Consultants of New York, New York, United States 8East Bay Retina Consultants, Inc., Oakland, California, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, United States 2Vitreous-Retina-Macula Consultants of New York, New York, United States 8East Bay Retina Consultants, Inc., Oakland, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Freund, K Bailey" sort="Freund, K Bailey" uniqKey="Freund K" first="K Bailey" last="Freund">K Bailey Freund</name><affiliation wicri:level="2"><nlm:affiliation>LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, United States 2Vitreous-Retina-Macula Consultants of New York, New York, United States 3Department of Ophthalmology, New York University School of Medicine, New York, New York, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, United States 2Vitreous-Retina-Macula Consultants of New York, New York, United States 3Department of Ophthalmology, New York University School of Medicine, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27760262</idno><idno type="pmid">27760262</idno><idno type="doi">10.1167/iovs.16-19816</idno><idno type="wicri:Area/PubMed/Corpus">001792</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001792</idno><idno type="wicri:Area/PubMed/Curation">001769</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001769</idno><idno type="wicri:Area/PubMed/Checkpoint">001769</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001769</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Associations Between Retinal Pigment Epithelium and Drusen Volume Changes During the Lifecycle of Large Drusenoid Pigment Epithelial Detachments.</title><author><name sortKey="Balaratnasingam, Chandrakumar" sort="Balaratnasingam, Chandrakumar" uniqKey="Balaratnasingam C" first="Chandrakumar" last="Balaratnasingam">Chandrakumar Balaratnasingam</name><affiliation wicri:level="1"><nlm:affiliation>LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, United States 2Vitreous-Retina-Macula Consultants of New York, New York, United States 3Department of Ophthalmology, New York University School of Medicine, New York, New York, United States 4Department of Physiology and Pharmacology, Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, United States 2Vitreous-Retina-Macula Consultants of New York, New York, United States 3Department of Ophthalmology, New York University School of Medicine, New York, New York, United States 4Department of Physiology and Pharmacology, Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth</wicri:regionArea><wicri:noRegion>Perth</wicri:noRegion></affiliation></author><author><name sortKey="Yannuzzi, Lawrence A" sort="Yannuzzi, Lawrence A" uniqKey="Yannuzzi L" first="Lawrence A" last="Yannuzzi">Lawrence A. Yannuzzi</name><affiliation wicri:level="2"><nlm:affiliation>LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, United States 2Vitreous-Retina-Macula Consultants of New York, New York, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, United States 2Vitreous-Retina-Macula Consultants of New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Curcio, Christine A" sort="Curcio, Christine A" uniqKey="Curcio C" first="Christine A" last="Curcio">Christine A. Curcio</name><affiliation wicri:level="2"><nlm:affiliation>Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, Alabama, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, Alabama</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Morgan, William H" sort="Morgan, William H" uniqKey="Morgan W" first="William H" last="Morgan">William H. Morgan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Ophthalmology, New York University School of Medicine, New York, New York, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, New York University School of Medicine, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Querques, Giuseppe" sort="Querques, Giuseppe" uniqKey="Querques G" first="Giuseppe" last="Querques">Giuseppe Querques</name><affiliation wicri:level="3"><nlm:affiliation>Department of Ophthalmology, Hospital Intercommunal de Creteil, University Paris Est Creteil, Creteil, France 7Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Ophthalmology, Hospital Intercommunal de Creteil, University Paris Est Creteil, Creteil, France 7Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Capuano, Vittorio" sort="Capuano, Vittorio" uniqKey="Capuano V" first="Vittorio" last="Capuano">Vittorio Capuano</name><affiliation wicri:level="3"><nlm:affiliation>Department of Ophthalmology, Hospital Intercommunal de Creteil, University Paris Est Creteil, Creteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Ophthalmology, Hospital Intercommunal de Creteil, University Paris Est Creteil, Creteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Souied, Eric" sort="Souied, Eric" uniqKey="Souied E" first="Eric" last="Souied">Eric Souied</name><affiliation wicri:level="3"><nlm:affiliation>Department of Ophthalmology, Hospital Intercommunal de Creteil, University Paris Est Creteil, Creteil, France 7Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Ophthalmology, Hospital Intercommunal de Creteil, University Paris Est Creteil, Creteil, France 7Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Jung, Jesse" sort="Jung, Jesse" uniqKey="Jung J" first="Jesse" last="Jung">Jesse Jung</name><affiliation wicri:level="2"><nlm:affiliation>LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, United States 2Vitreous-Retina-Macula Consultants of New York, New York, United States 8East Bay Retina Consultants, Inc., Oakland, California, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, United States 2Vitreous-Retina-Macula Consultants of New York, New York, United States 8East Bay Retina Consultants, Inc., Oakland, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Freund, K Bailey" sort="Freund, K Bailey" uniqKey="Freund K" first="K Bailey" last="Freund">K Bailey Freund</name><affiliation wicri:level="2"><nlm:affiliation>LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, United States 2Vitreous-Retina-Macula Consultants of New York, New York, United States 3Department of Ophthalmology, New York University School of Medicine, New York, New York, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, United States 2Vitreous-Retina-Macula Consultants of New York, New York, United States 3Department of Ophthalmology, New York University School of Medicine, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j">Investigative ophthalmology & visual science</title><idno type="eISSN">1552-5783</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Disease Progression</term><term>Female</term><term>Fluorescein Angiography</term><term>Follow-Up Studies</term><term>Fundus Oculi</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prognosis</term><term>Retinal Detachment (diagnosis)</term><term>Retinal Detachment (etiology)</term><term>Retinal Drusen (complications)</term><term>Retinal Drusen (diagnosis)</term><term>Retinal Pigment Epithelium (pathology)</term><term>Retrospective Studies</term><term>Time Factors</term><term>Tomography, Optical Coherence (methods)</term><term>Visual Acuity</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acuité visuelle</term><term>Adulte d'âge moyen</term><term>Angiographie fluorescéinique</term><term>Druses de la rétine ()</term><term>Druses de la rétine (diagnostic)</term><term>Décollement de la rétine (diagnostic)</term><term>Décollement de la rétine (étiologie)</term><term>Facteurs temps</term><term>Femelle</term><term>Fond de l'oeil</term><term>Humains</term><term>Mâle</term><term>Pronostic</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tomographie par cohérence optique ()</term><term>Épithélium pigmentaire de la rétine (anatomopathologie)</term><term>Études de suivi</term><term>Études rétrospectives</term><term>Évolution de la maladie</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Épithélium pigmentaire de la rétine</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Retinal Drusen</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Retinal Detachment</term><term>Retinal Drusen</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Druses de la rétine</term><term>Décollement de la rétine</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Retinal Detachment</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Tomography, Optical Coherence</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Retinal Pigment Epithelium</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Décollement de la rétine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Disease Progression</term><term>Female</term><term>Fluorescein Angiography</term><term>Follow-Up Studies</term><term>Fundus Oculi</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prognosis</term><term>Retrospective Studies</term><term>Time Factors</term><term>Visual Acuity</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Acuité visuelle</term><term>Adulte d'âge moyen</term><term>Angiographie fluorescéinique</term><term>Druses de la rétine</term><term>Facteurs temps</term><term>Femelle</term><term>Fond de l'oeil</term><term>Humains</term><term>Mâle</term><term>Pronostic</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tomographie par cohérence optique</term><term>Études de suivi</term><term>Études rétrospectives</term><term>Évolution de la maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Drusenoid pigment epithelial detachments (PEDs) are a defined path to atrophy in age-related macular degeneration (AMD). We analyzed the relationships between retinal pigment epithelium (RPE) and drusen volume changes during the PED lifecycle, using spectral-domain optical coherence tomography (SD-OCT).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27760262</PMID><DateCreated><Year>2016</Year><Month>10</Month><Day>19</Day></DateCreated><DateCompleted><Year>2017</Year><Month>05</Month><Day>26</Day></DateCompleted><DateRevised><Year>2017</Year><Month>05</Month><Day>26</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1552-5783</ISSN><JournalIssue CitedMedium="Internet"><Volume>57</Volume><Issue>13</Issue><PubDate><Year>2016</Year><Month>Oct</Month><Day>01</Day></PubDate></JournalIssue><Title>Investigative ophthalmology & visual science</Title><ISOAbbreviation>Invest. Ophthalmol. Vis. Sci.</ISOAbbreviation></Journal><ArticleTitle>Associations Between Retinal Pigment Epithelium and Drusen Volume Changes During the Lifecycle of Large Drusenoid Pigment Epithelial Detachments.</ArticleTitle><Pagination><MedlinePgn>5479-5489</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1167/iovs.16-19816</ELocationID><Abstract><AbstractText Label="Purpose" NlmCategory="UNASSIGNED">Drusenoid pigment epithelial detachments (PEDs) are a defined path to atrophy in age-related macular degeneration (AMD). We analyzed the relationships between retinal pigment epithelium (RPE) and drusen volume changes during the PED lifecycle, using spectral-domain optical coherence tomography (SD-OCT).</AbstractText><AbstractText Label="Methods" NlmCategory="UNASSIGNED">Twenty-one cases of drusenoid PED tracked using SD-OCT through periods of growth and collapse were evaluated. Volumetric calculations and piece-wise linear regression analysis were used to determine the breakpoint between growth and collapse. Spectral-domain OCT scans were independently evaluated for the appearance of intraretinal hyperreflective foci, acquired vitelliform lesions (AVLs), and disruptions to the RPE+basal lamina band. Timing of these events with respect to the breakpoint was statistically evaluated. Morphometric characteristics of drusenoid PEDs were correlated with rate of PED collapse and final visual acuity.</AbstractText><AbstractText Label="Results" NlmCategory="UNASSIGNED">Mean age of subjects was 75.3 years and mean period of follow up was 4.1 years (median 4.5 years; range, 0.6-6.6 years). The lifecycle of drusenoid PEDs was asymmetric, in that the rate of collapse (0.199 mm3/month) is significantly faster (P < 0.001) than the rate of growth (0.022 mm3/month). Appearance of intraretinal hyperreflective foci and AVLs preceded the breakpoint (both P < 0.001). The timing of disruptions to the RPE+basal lamina band did not differ from the breakpoint (P = 0.510). Maximal height, volume, and diameter of drusenoid PEDs were inversely correlated with final visual acuity (all P < 0.001) and positively correlated with the rate of PED collapse (all P < 0.001).</AbstractText><AbstractText Label="Conclusions" NlmCategory="UNASSIGNED">Spectral-domain OCT signatures, plausibly attributable to anteriorly migrated RPE and disintegration of the RPE layer, precede or occur simultaneously with changes in volume of drusenoid PED during the lifecycle of this lesion.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Balaratnasingam</LastName><ForeName>Chandrakumar</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, United States 2Vitreous-Retina-Macula Consultants of New York, New York, United States 3Department of Ophthalmology, New York University School of Medicine, New York, New York, United States 4Department of Physiology and Pharmacology, Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yannuzzi</LastName><ForeName>Lawrence A</ForeName><Initials>LA</Initials><AffiliationInfo><Affiliation>LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, United States 2Vitreous-Retina-Macula Consultants of New York, New York, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Curcio</LastName><ForeName>Christine A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, Alabama, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morgan</LastName><ForeName>William H</ForeName><Initials>WH</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, New York University School of Medicine, New York, New York, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Querques</LastName><ForeName>Giuseppe</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Hospital Intercommunal de Creteil, University Paris Est Creteil, Creteil, France 7Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Capuano</LastName><ForeName>Vittorio</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Hospital Intercommunal de Creteil, University Paris Est Creteil, Creteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Souied</LastName><ForeName>Eric</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Hospital Intercommunal de Creteil, University Paris Est Creteil, Creteil, France 7Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jung</LastName><ForeName>Jesse</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, United States 2Vitreous-Retina-Macula Consultants of New York, New York, United States 8East Bay Retina Consultants, Inc., Oakland, California, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Freund</LastName><ForeName>K Bailey</ForeName><Initials>KB</Initials><AffiliationInfo><Affiliation>LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, United States 2Vitreous-Retina-Macula Consultants of New York, New York, United States 3Department of Ophthalmology, New York University School of Medicine, New York, New York, United States.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 EY006109</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Invest Ophthalmol Vis Sci</MedlineTA><NlmUniqueID>7703701</NlmUniqueID><ISSNLinking>0146-0404</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Am J Ophthalmol. 2015 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Version="1">21091424</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018450" MajorTopicYN="N">Disease Progression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005451" MajorTopicYN="N">Fluorescein Angiography</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005654" MajorTopicYN="N">Fundus Oculi</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012163" MajorTopicYN="N">Retinal Detachment</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015593" MajorTopicYN="N">Retinal Drusen</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055213" MajorTopicYN="N">Retinal Pigment Epithelium</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D041623" MajorTopicYN="N">Tomography, Optical Coherence</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014792" MajorTopicYN="Y">Visual Acuity</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>10</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>5</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>10</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27760262</ArticleId><ArticleId IdType="pii">2571542</ArticleId><ArticleId IdType="doi">10.1167/iovs.16-19816</ArticleId><ArticleId IdType="pmc">PMC5072538</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>France</li><li>Italie</li><li>États-Unis</li></country><region><li>Alabama</li><li>Californie</li><li>Lombardie</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Créteil</li><li>Milan</li></settlement></list><tree><country name="Australie"><noRegion><name sortKey="Balaratnasingam, Chandrakumar" sort="Balaratnasingam, Chandrakumar" uniqKey="Balaratnasingam C" first="Chandrakumar" last="Balaratnasingam">Chandrakumar Balaratnasingam</name></noRegion></country><country name="États-Unis"><region name="État de New York"><name sortKey="Yannuzzi, Lawrence A" sort="Yannuzzi, Lawrence A" uniqKey="Yannuzzi L" first="Lawrence A" last="Yannuzzi">Lawrence A. Yannuzzi</name></region><name sortKey="Curcio, Christine A" sort="Curcio, Christine A" uniqKey="Curcio C" first="Christine A" last="Curcio">Christine A. Curcio</name><name sortKey="Freund, K Bailey" sort="Freund, K Bailey" uniqKey="Freund K" first="K Bailey" last="Freund">K Bailey Freund</name><name sortKey="Jung, Jesse" sort="Jung, Jesse" uniqKey="Jung J" first="Jesse" last="Jung">Jesse Jung</name><name sortKey="Morgan, William H" sort="Morgan, William H" uniqKey="Morgan W" first="William H" last="Morgan">William H. Morgan</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Querques, Giuseppe" sort="Querques, Giuseppe" uniqKey="Querques G" first="Giuseppe" last="Querques">Giuseppe Querques</name></region><name sortKey="Souied, Eric" sort="Souied, Eric" uniqKey="Souied E" first="Eric" last="Souied">Eric Souied</name></country><country name="France"><region name="Île-de-France"><name sortKey="Capuano, Vittorio" sort="Capuano, Vittorio" uniqKey="Capuano V" first="Vittorio" last="Capuano">Vittorio Capuano</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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