Genome-wide association analysis identifies three new breast cancer susceptibility loci
Identifieur interne : 002C60 ( Pmc/Curation ); précédent : 002C59; suivant : 002C61Genome-wide association analysis identifies three new breast cancer susceptibility loci
Auteurs : Maya Ghoussaini [Royaume-Uni] ; Olivia Fletcher [Royaume-Uni] ; Kyriaki Michailidou [Royaume-Uni] ; Clare Turnbull [Royaume-Uni] ; Marjanka K. Schmidt [Pays-Bas] ; Ed Dicks [Royaume-Uni] ; Joe Dennis [Royaume-Uni] ; Qin Wang [Royaume-Uni] ; Manjeet K. Humphreys [Royaume-Uni] ; Craig Luccarini [Royaume-Uni] ; Caroline Baynes [Royaume-Uni] ; Don Conroy [Royaume-Uni] ; Melanie Maranian [Royaume-Uni] ; Shahana Ahmed [Royaume-Uni] ; Kristy Driver [Royaume-Uni] ; Nichola Johnson [Royaume-Uni] ; Nicholas Orr [Royaume-Uni] ; Isabel Dos Santos Silva [Royaume-Uni] ; Quinten Waisfisz [Pays-Bas] ; Hanne Meijers-Heijboer [Pays-Bas] ; Andre G. Uitterlinden [Pays-Bas] ; Fernando Rivadeneira [Pays-Bas] ; Per Hall [Suède] ; Kamila Czene [Suède] ; Astrid Irwanto [Finlande] ; Jianjun Liu [Singapour] ; Heli Nevanlinna [Finlande] ; Kristiina Aittom Ki [Finlande] ; Carl Blomqvist [Finlande] ; Alfons Meindl [Allemagne] ; Rita K. Schmutzler [Allemagne] ; Bertram Müller-Myhsok [Allemagne] ; Peter Lichtner [Allemagne] ; Jenny Chang-Claude [Allemagne] ; Rebecca Hein [Allemagne] ; Stefan Nickels [Allemagne] ; Dieter Flesch-Janys [Allemagne] ; Helen Tsimiklis [Australie] ; Enes Makalic [Australie] ; Daniel Schmidt [Australie] ; Minh Bui [Australie] ; John L. Hopper [Australie] ; Carmel Apicella [Australie] ; Daniel J. Park [Australie] ; Melissa Southey [Australie] ; David J. Hunter [États-Unis] ; Stephen J. Chanock [États-Unis] ; Annegien Broeks [Pays-Bas] ; Senno Verhoef [Pays-Bas] ; Frans Bl Hogervorst [Pays-Bas] ; Peter A. Fasching [Allemagne] ; Michael P. Lux [Allemagne] ; Matthias W. Beckmann [Allemagne] ; Arif B. Ekici [Allemagne] ; Elinor Sawyer [Royaume-Uni] ; Ian Tomlinson [Royaume-Uni] ; Michael Kerin [Irlande (pays)] ; Frederik Marme [Allemagne] ; Andreas Schneeweiss [Allemagne] ; Christof Sohn [Allemagne] ; Barbara Burwinkel [Allemagne] ; Pascal Guénel [France] ; Thérèse Truong [France] ; Emilie Cordina-Duverger [France] ; Florence Menegaux [France] ; Stig E. Bojesen [Danemark] ; B Rge G. Nordestgaard [Danemark] ; Sune F. Nielsen [Danemark] ; Henrik Flyger [Danemark] ; Roger L. Milne [Espagne] ; M. Rosario Alonso [Espagne] ; Anna González-Neira [Espagne] ; Javier Benítez [Espagne] ; Hoda Anton-Culver [États-Unis] ; Argyrios Ziogas [États-Unis] ; Leslie Bernstein [États-Unis] ; Christina Clarke Dur [États-Unis] ; Hermann Brenner [Allemagne] ; Heiko Müller [Allemagne] ; Volker Arndt [Allemagne] ; Christa Stegmaier [Allemagne] ; Christina Justenhoven [Allemagne] ; Hiltrud Brauch [Allemagne] ; Thomas Brüning [Allemagne] ; Shan Wang-Gohrke [Allemagne] ; Ursula Eilber [Allemagne] ; Thilo Dörk [Allemagne] ; Peter Schürmann [Allemagne] ; Michael Bremer [Allemagne] ; Peter Hillemanns [Allemagne] ; Natalia V. Bogdanova [Allemagne] ; Natalia N. Antonenkova [Biélorussie] ; Yuri I. Rogov [Biélorussie] ; Johann H. Karstens [Allemagne] ; Marina Bermisheva [Russie] ; Darya Prokofieva [Russie] ; Elza Khusnutdinova [Russie] ; Annika Lindblom [Suède] ; Sara Margolin [Suède] ; Arto Mannermaa [Finlande] ; Vesa Kataja [Finlande] ; Veli-Matti Kosma [Finlande] ; Jaana M. Hartikainen [Finlande] ; Diether Lambrechts [Belgique] ; Betul T. Yesilyurt [Belgique] ; Giuseppe Floris [Belgique] ; Karin Leunen [Belgique] ; Siranoush Manoukian [Italie] ; Bernardo Bonanni [Italie] ; Stefano Fortuzzi [Italie] ; Paolo Peterlongo [Italie] ; Fergus J. Couch [États-Unis] ; Xianshu Wang [États-Unis] ; Kristen Stevens [États-Unis] ; Adam Lee [États-Unis] ; Graham G. Giles [Australie] ; Laura Baglietto [Australie] ; Gianluca Severi [Australie] ; Catriona Mclean [Australie] ; Grethe Grenaker Aln S [Norvège] ; Vessela Kristensen [Norvège] ; Anne-Lise B Rrensen-Dale [Norvège] ; Esther M. John [États-Unis] ; Alexander Miron [États-Unis] ; Robert Winqvist [Finlande] ; Katri Pylk S [Finlande] ; Arja Jukkola-Vuorinen [Finlande] ; Saila Kauppila [Finlande] ; Irene L. Andrulis [Canada] ; Gord Glendon [Canada] ; Anna Marie Mulligan [Canada] ; Peter Devilee [Pays-Bas] ; Christie J. Van Asperen [Pays-Bas] ; Rob A. E. M. Tollenaar [Pays-Bas] ; Caroline Seynaeve [Pays-Bas] ; Jonine D. Figueroa [États-Unis] ; Montserrat Garcia-Closas [Royaume-Uni] ; Louise Brinton [États-Unis] ; Jolanta Lissowska [Pologne] ; Maartje J. Hooning [Pays-Bas] ; Antoinette Hollestelle [Pays-Bas] ; Rogier A. Oldenburg [Pays-Bas] ; Ans M. W. Van Den Ouweland [Pays-Bas] ; Angela Cox [Royaume-Uni] ; Malcolm Wr Reed [Royaume-Uni] ; Mitul Shah [Royaume-Uni] ; Ania Jakubowska [Pologne] ; Jan Lubinski [Pologne] ; Katarzyna Jaworska [Pologne] ; Katarzyna Durda [Pologne] ; Michael Jones [Royaume-Uni] ; Minouk Schoemaker [Royaume-Uni] ; Alan Ashworth [Royaume-Uni] ; Anthony Swerdlow [Royaume-Uni] ; Jonathan Beesley [Australie] ; Xiaoqing Chen [Australie] ; Kenneth R. Muir [Royaume-Uni] ; Artitaya Lophatananon [Royaume-Uni] ; Suthee Rattanamongkongul [Thaïlande] ; Arkom Chaiwerawattana [Thaïlande] ; Daehee Kang [Corée du Sud] ; Keun-Young Yoo [Corée du Sud] ; Dong-Young Noh [Corée du Sud] ; Chen-Yang Shen [Taïwan] ; Jyh-Cherng Yu [Taïwan] ; Pei-Ei Wu [Taïwan] ; Chia-Ni Hsiung [Taïwan] ; Annie Perkins [Royaume-Uni] ; Ruth Swann [Royaume-Uni] ; Louiza Velentzis [Royaume-Uni] ; Diana M. Eccles [Royaume-Uni] ; Will J. Tapper [Royaume-Uni] ; Susan M. Gerty [Royaume-Uni] ; Nikki J. Graham [Royaume-Uni] ; Bruce A. J. Ponder [Royaume-Uni] ; Georgia Chenevix-Trench [Australie] ; Paul D. P. Pharoah [Royaume-Uni] ; Mark Lathrop [France] ; Alison M. Dunning [Royaume-Uni] ; Nazneen Rahman [Royaume-Uni] ; Julian Peto [Royaume-Uni] ; Douglas F. Easton [Royaume-Uni]Source :
- Nature genetics [ 1061-4036 ] ; 2012.
Abstract
Breast cancer is the most common cancer among women. To date, 22 common breast cancer susceptibility loci have been identified accounting for ~ 8% of the heritability of the disease. We followed up 72 promising associations from two independent Genome Wide Association Studies (GWAS) in ~70,000 cases and ~68,000 controls from 41 case-control studies and nine breast cancer GWAS. We identified three new breast cancer risk loci on 12p11 (rs10771399;
Url:
DOI: 10.1038/ng.1049
PubMed: 22267197
PubMed Central: 3653403
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Arto Mannermaa<affiliation><nlm:aff id="A64">Biocenter Kuopio, Kuopio Finland</nlm:aff><wicri:noCountry code="subfield">Kuopio Finland</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A65">Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Pathology, Kuopio University Hospital, Kuopio</wicri:regionArea></affiliation><affiliation><nlm:aff id="A64">Biocenter Kuopio, Kuopio Finland</nlm:aff><wicri:noCountry code="subfield">Kuopio Finland</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A66">School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland, Kuopio</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A67">Department of Oncology, Kuopio University Hospital, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Oncology, Kuopio University Hospital, Kuopio</wicri:regionArea></affiliation><affiliation><nlm:aff id="A64">Biocenter Kuopio, Kuopio Finland</nlm:aff><wicri:noCountry code="subfield">Kuopio Finland</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A65">Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Pathology, Kuopio University Hospital, Kuopio</wicri:regionArea></affiliation><affiliation><nlm:aff id="A64">Biocenter Kuopio, Kuopio Finland</nlm:aff><wicri:noCountry code="subfield">Kuopio Finland</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A65">Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Pathology, Kuopio University Hospital, Kuopio</wicri:regionArea></affiliation><affiliation><nlm:aff id="A87">Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital</nlm:aff><wicri:noCountry code="subfield">Mount Sinai Hospital</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A88">Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Molecular Genetics, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation>Le document en format XML
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Schmidt</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Experimental Therapy, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Experimental Therapy, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Department of Epidemiology, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Dicks, Ed" sort="Dicks, Ed" uniqKey="Dicks E" first="Ed" last="Dicks">Ed Dicks</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation wicri:level="1"><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation wicri:level="1"><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Humphreys, Manjeet K" sort="Humphreys, Manjeet K" uniqKey="Humphreys M" first="Manjeet K" last="Humphreys">Manjeet K. Humphreys</name><affiliation wicri:level="1"><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Luccarini, Craig" sort="Luccarini, Craig" uniqKey="Luccarini C" first="Craig" last="Luccarini">Craig Luccarini</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Baynes, Caroline" sort="Baynes, Caroline" uniqKey="Baynes C" first="Caroline" last="Baynes">Caroline Baynes</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Conroy, Don" sort="Conroy, Don" uniqKey="Conroy D" first="Don" last="Conroy">Don Conroy</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Maranian, Melanie" sort="Maranian, Melanie" uniqKey="Maranian M" first="Melanie" last="Maranian">Melanie Maranian</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Ahmed, Shahana" sort="Ahmed, Shahana" uniqKey="Ahmed S" first="Shahana" last="Ahmed">Shahana Ahmed</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Driver, Kristy" sort="Driver, Kristy" uniqKey="Driver K" first="Kristy" last="Driver">Kristy Driver</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation wicri:level="1"><nlm:aff id="A2">Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London</wicri:regionArea></affiliation></author><author><name sortKey="Orr, Nicholas" sort="Orr, Nicholas" uniqKey="Orr N" first="Nicholas" last="Orr">Nicholas Orr</name><affiliation wicri:level="1"><nlm:aff id="A2">Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London</wicri:regionArea></affiliation></author><author><name sortKey="Silva, Isabel Dos Santos" sort="Silva, Isabel Dos Santos" uniqKey="Silva I" first="Isabel Dos Santos" last="Silva">Isabel Dos Santos Silva</name><affiliation wicri:level="1"><nlm:aff id="A7">Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London</wicri:regionArea></affiliation></author><author><name sortKey="Waisfisz, Quinten" sort="Waisfisz, Quinten" uniqKey="Waisfisz Q" first="Quinten" last="Waisfisz">Quinten Waisfisz</name><affiliation wicri:level="1"><nlm:aff id="A8">Department of Clinical Genetics, VU University Medical Center, section Oncogenetics, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, VU University Medical Center, section Oncogenetics, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Meijers Heijboer, Hanne" sort="Meijers Heijboer, Hanne" uniqKey="Meijers Heijboer H" first="Hanne" last="Meijers-Heijboer">Hanne Meijers-Heijboer</name><affiliation wicri:level="1"><nlm:aff id="A8">Department of Clinical Genetics, VU University Medical Center, section Oncogenetics, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, VU University Medical Center, section Oncogenetics, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Internal Medicine and Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine and Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Internal Medicine and Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine and Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation wicri:level="1"><nlm:aff id="A11">Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177</wicri:regionArea></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation wicri:level="1"><nlm:aff id="A11">Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177</wicri:regionArea></affiliation></author><author><name sortKey="Irwanto, Astrid" sort="Irwanto, Astrid" uniqKey="Irwanto A" first="Astrid" last="Irwanto">Astrid Irwanto</name><affiliation wicri:level="1"><nlm:aff id="A13">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation wicri:level="1"><nlm:aff id="A12">Human Genetics Division, Genome Institute of Singapore, Singapore 138672, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Human Genetics Division, Genome Institute of Singapore, Singapore 138672</wicri:regionArea></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation wicri:level="1"><nlm:aff id="A13">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation wicri:level="1"><nlm:aff id="A14">Department of Clinical Genetics, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Genetics, University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation wicri:level="1"><nlm:aff id="A15">Department of Oncology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Oncology, University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation wicri:level="1"><nlm:aff id="A16">Clinic of Gynaecology and Obstetrics, Division for Gynaecological Tumor-Genetics, Technische Universität München, München, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Clinic of Gynaecology and Obstetrics, Division for Gynaecological Tumor-Genetics, Technische Universität München, München</wicri:regionArea></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K" last="Schmutzler">Rita K. Schmutzler</name><affiliation wicri:level="1"><nlm:aff id="A17">Department of Obstetrics and Gynaecology, Division of Molecular Gynaeco-Oncology, University of Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynaecology, Division of Molecular Gynaeco-Oncology, University of Cologne</wicri:regionArea></affiliation></author><author><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name><affiliation wicri:level="1"><nlm:aff id="A18">Max Planck Institute of Psychiatry, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute of Psychiatry, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Lichtner, Peter" sort="Lichtner, Peter" uniqKey="Lichtner P" first="Peter" last="Lichtner">Peter Lichtner</name><affiliation wicri:level="1"><nlm:aff id="A19">Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation wicri:level="1"><nlm:aff id="A20">Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Hein, Rebecca" sort="Hein, Rebecca" uniqKey="Hein R" first="Rebecca" last="Hein">Rebecca Hein</name><affiliation wicri:level="1"><nlm:aff id="A20">Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A21">PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, University of Cologne, Cologne</wicri:regionArea></affiliation></author><author><name sortKey="Nickels, Stefan" sort="Nickels, Stefan" uniqKey="Nickels S" first="Stefan" last="Nickels">Stefan Nickels</name><affiliation wicri:level="1"><nlm:aff id="A20">Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation wicri:level="1"><nlm:aff id="A22">Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Hamburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Hamburg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A23">Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg</wicri:regionArea></affiliation></author><author><name sortKey="Tsimiklis, Helen" sort="Tsimiklis, Helen" uniqKey="Tsimiklis H" first="Helen" last="Tsimiklis">Helen Tsimiklis</name><affiliation wicri:level="1"><nlm:aff id="A24">Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name><affiliation wicri:level="1"><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Daniel" sort="Schmidt, Daniel" uniqKey="Schmidt D" first="Daniel" last="Schmidt">Daniel Schmidt</name><affiliation wicri:level="1"><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Bui, Minh" sort="Bui, Minh" uniqKey="Bui M" first="Minh" last="Bui">Minh Bui</name><affiliation wicri:level="1"><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation wicri:level="1"><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation wicri:level="1"><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Park, Daniel J" sort="Park, Daniel J" uniqKey="Park D" first="Daniel J" last="Park">Daniel J. Park</name><affiliation wicri:level="1"><nlm:aff id="A24">Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Southey, Melissa" sort="Southey, Melissa" uniqKey="Southey M" first="Melissa" last="Southey">Melissa Southey</name><affiliation wicri:level="1"><nlm:aff id="A24">Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name><affiliation wicri:level="1"><nlm:aff id="A26">Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="1"><nlm:aff id="A27">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Experimental Therapy, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Experimental Therapy, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Verhoef, Senno" sort="Verhoef, Senno" uniqKey="Verhoef S" first="Senno" last="Verhoef">Senno Verhoef</name><affiliation wicri:level="1"><nlm:aff id="A28">Department of Clinical Genetics, Family Cancer Clinic, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Family Cancer Clinic, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Hogervorst, Frans Bl" sort="Hogervorst, Frans Bl" uniqKey="Hogervorst F" first="Frans Bl" last="Hogervorst">Frans Bl Hogervorst</name><affiliation wicri:level="1"><nlm:aff id="A29">Department of Molecular Pathology, Family Cancer Clinic, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Molecular Pathology, Family Cancer Clinic, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation wicri:level="1"><nlm:aff id="A30">University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen</wicri:regionArea></affiliation></author><author><name sortKey="Lux, Michael P" sort="Lux, Michael P" uniqKey="Lux M" first="Michael P." last="Lux">Michael P. Lux</name><affiliation wicri:level="1"><nlm:aff id="A30">University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen</wicri:regionArea></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation wicri:level="1"><nlm:aff id="A30">University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen</wicri:regionArea></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation wicri:level="1"><nlm:aff id="A31">Institute of Human Genetics, Friedrich-Alexander University Erlangen Nuremberg, Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, Friedrich-Alexander University Erlangen Nuremberg, Erlangen</wicri:regionArea></affiliation></author><author><name sortKey="Sawyer, Elinor" sort="Sawyer, Elinor" uniqKey="Sawyer E" first="Elinor" last="Sawyer">Elinor Sawyer</name><affiliation wicri:level="1"><nlm:aff id="A32">Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ NHS Foundation Trust in partnership with King’s College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ NHS Foundation Trust in partnership with King’s College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation wicri:level="1"><nlm:aff id="A33">Welcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Welcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Kerin, Michael" sort="Kerin, Michael" uniqKey="Kerin M" first="Michael" last="Kerin">Michael Kerin</name><affiliation wicri:level="1"><nlm:aff id="A34">Clinical Science Institute, University Hospital Galway, Galway, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Clinical Science Institute, University Hospital Galway, Galway</wicri:regionArea></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><affiliation wicri:level="1"><nlm:aff id="A35">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A36">National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>National Center for Tumor Diseases, University of Heidelberg, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Schneeweiss, Andreas" sort="Schneeweiss, Andreas" uniqKey="Schneeweiss A" first="Andreas" last="Schneeweiss">Andreas Schneeweiss</name><affiliation wicri:level="1"><nlm:aff id="A35">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A36">National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>National Center for Tumor Diseases, University of Heidelberg, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Sohn, Christof" sort="Sohn, Christof" uniqKey="Sohn C" first="Christof" last="Sohn">Christof Sohn</name><affiliation wicri:level="1"><nlm:aff id="A35">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation wicri:level="1"><nlm:aff id="A35">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A37">Molecular Epidemiology Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Molecular Epidemiology Unit, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation wicri:level="1"><nlm:aff id="A38">Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Environmental epidemiology of cancer, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Environmental epidemiology of cancer, Villejuif</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A39">Université Paris-Sud, UMRS 1018, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Sud, UMRS 1018, Villejuif</wicri:regionArea></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation wicri:level="1"><nlm:aff id="A38">Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Environmental epidemiology of cancer, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Environmental epidemiology of cancer, Villejuif</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A39">Université Paris-Sud, UMRS 1018, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Sud, UMRS 1018, Villejuif</wicri:regionArea></affiliation></author><author><name sortKey="Cordina Duverger, Emilie" sort="Cordina Duverger, Emilie" uniqKey="Cordina Duverger E" first="Emilie" last="Cordina-Duverger">Emilie Cordina-Duverger</name><affiliation wicri:level="1"><nlm:aff id="A38">Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Environmental epidemiology of cancer, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Environmental epidemiology of cancer, Villejuif</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A39">Université Paris-Sud, UMRS 1018, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Sud, UMRS 1018, Villejuif</wicri:regionArea></affiliation></author><author><name sortKey="Menegaux, Florence" sort="Menegaux, Florence" uniqKey="Menegaux F" first="Florence" last="Menegaux">Florence Menegaux</name><affiliation wicri:level="1"><nlm:aff id="A38">Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Environmental epidemiology of cancer, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Environmental epidemiology of cancer, Villejuif</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A39">Université Paris-Sud, UMRS 1018, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Sud, UMRS 1018, Villejuif</wicri:regionArea></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E" last="Bojesen">Stig E. Bojesen</name><affiliation wicri:level="1"><nlm:aff id="A40">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A41">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G" last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation wicri:level="1"><nlm:aff id="A40">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A41">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Nielsen, Sune F" sort="Nielsen, Sune F" uniqKey="Nielsen S" first="Sune F" last="Nielsen">Sune F. Nielsen</name><affiliation wicri:level="1"><nlm:aff id="A40">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A41">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation wicri:level="1"><nlm:aff id="A42">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation wicri:level="1"><nlm:aff id="A43">Genetic & Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetic & Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Alonso, M Rosario" sort="Alonso, M Rosario" uniqKey="Alonso M" first="M. Rosario" last="Alonso">M. Rosario Alonso</name><affiliation wicri:level="1"><nlm:aff id="A44">Human Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Human Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name><affiliation wicri:level="1"><nlm:aff id="A44">Human Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Human Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name><affiliation wicri:level="1"><nlm:aff id="A45">Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation wicri:level="1"><nlm:aff id="A46">Department of Epidemiology, University of California Irvine, Irvine, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of California Irvine, Irvine, California</wicri:regionArea></affiliation></author><author><name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name><affiliation wicri:level="1"><nlm:aff id="A46">Department of Epidemiology, University of California Irvine, Irvine, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of California Irvine, Irvine, California</wicri:regionArea></affiliation></author><author><name sortKey="Bernstein, Leslie" sort="Bernstein, Leslie" uniqKey="Bernstein L" first="Leslie" last="Bernstein">Leslie Bernstein</name><affiliation wicri:level="1"><nlm:aff id="A47">City of Hope Cancer Centre, Duarte, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>City of Hope Cancer Centre, Duarte, California</wicri:regionArea></affiliation></author><author><name sortKey="Dur, Christina Clarke" sort="Dur, Christina Clarke" uniqKey="Dur C" first="Christina Clarke" last="Dur">Christina Clarke Dur</name><affiliation wicri:level="1"><nlm:aff id="A48">Cancer Prevention Institute of California, Fremont, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Prevention Institute of California, Fremont, California</wicri:regionArea></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="1"><nlm:aff id="A49">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center [DKFZ], Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center [DKFZ], Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Muller, Heiko" sort="Muller, Heiko" uniqKey="Muller H" first="Heiko" last="Müller">Heiko Müller</name><affiliation wicri:level="1"><nlm:aff id="A49">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center [DKFZ], Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center [DKFZ], Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation wicri:level="1"><nlm:aff id="A49">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center [DKFZ], Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center [DKFZ], Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name><affiliation wicri:level="1"><nlm:aff id="A50">Saarland Cancer Registry, Saarbrücken, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Saarland Cancer Registry, Saarbrücken</wicri:regionArea></affiliation></author><author><name sortKey="Justenhoven, Christina" sort="Justenhoven, Christina" uniqKey="Justenhoven C" first="Christina" last="Justenhoven">Christina Justenhoven</name><affiliation wicri:level="3"><nlm:aff id="A51">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart</nlm:aff><country>Allemagne</country><placeName><settlement type="city">Stuttgart</settlement><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Stuttgart</region></placeName><wicri:orgArea>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology</wicri:orgArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A52">University of Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation wicri:level="3"><nlm:aff id="A51">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart</nlm:aff><country>Allemagne</country><placeName><settlement type="city">Stuttgart</settlement><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Stuttgart</region></placeName><wicri:orgArea>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology</wicri:orgArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A52">University of Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><affiliation wicri:level="1"><nlm:aff id="A53">Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum</wicri:regionArea></affiliation></author><author><name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name><affiliation wicri:level="1"><nlm:aff id="A56">Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Ulm, Ulm</wicri:regionArea></affiliation></author><author><name sortKey="Eilber, Ursula" sort="Eilber, Ursula" uniqKey="Eilber U" first="Ursula" last="Eilber">Ursula Eilber</name><affiliation wicri:level="1"><nlm:aff id="A20">Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation wicri:level="1"><nlm:aff id="A57">Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover</wicri:regionArea></affiliation></author><author><name sortKey="Schurmann, Peter" sort="Schurmann, Peter" uniqKey="Schurmann P" first="Peter" last="Schürmann">Peter Schürmann</name><affiliation wicri:level="1"><nlm:aff id="A57">Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover</wicri:regionArea></affiliation></author><author><name sortKey="Bremer, Michael" sort="Bremer, Michael" uniqKey="Bremer M" first="Michael" last="Bremer">Michael Bremer</name><affiliation wicri:level="1"><nlm:aff id="A57">Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover</wicri:regionArea></affiliation></author><author><name sortKey="Hillemanns, Peter" sort="Hillemanns, Peter" uniqKey="Hillemanns P" first="Peter" last="Hillemanns">Peter Hillemanns</name><affiliation wicri:level="1"><nlm:aff id="A57">Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover</wicri:regionArea></affiliation></author><author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name><affiliation wicri:level="1"><nlm:aff id="A58">Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Radiation Oncology, Hannover Medical School, Hannover</wicri:regionArea></affiliation></author><author><name sortKey="Antonenkova, Natalia N" sort="Antonenkova, Natalia N" uniqKey="Antonenkova N" first="Natalia N." last="Antonenkova">Natalia N. Antonenkova</name><affiliation wicri:level="1"><nlm:aff id="A59">N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus</nlm:aff><country xml:lang="fr">Biélorussie</country><wicri:regionArea>N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk</wicri:regionArea></affiliation></author><author><name sortKey="Rogov, Yuri I" sort="Rogov, Yuri I" uniqKey="Rogov Y" first="Yuri I." last="Rogov">Yuri I. Rogov</name><affiliation wicri:level="1"><nlm:aff id="A59">N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus</nlm:aff><country xml:lang="fr">Biélorussie</country><wicri:regionArea>N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk</wicri:regionArea></affiliation></author><author><name sortKey="Karstens, Johann H" sort="Karstens, Johann H" uniqKey="Karstens J" first="Johann H." last="Karstens">Johann H. Karstens</name><affiliation wicri:level="1"><nlm:aff id="A58">Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Radiation Oncology, Hannover Medical School, Hannover</wicri:regionArea></affiliation></author><author><name sortKey="Bermisheva, Marina" sort="Bermisheva, Marina" uniqKey="Bermisheva M" first="Marina" last="Bermisheva">Marina Bermisheva</name><affiliation wicri:level="1"><nlm:aff id="A60">Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa</wicri:regionArea></affiliation></author><author><name sortKey="Prokofieva, Darya" sort="Prokofieva, Darya" uniqKey="Prokofieva D" first="Darya" last="Prokofieva">Darya Prokofieva</name><affiliation wicri:level="1"><nlm:aff id="A60">Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa</wicri:regionArea></affiliation></author><author><name sortKey="Khusnutdinova, Elza" sort="Khusnutdinova, Elza" uniqKey="Khusnutdinova E" first="Elza" last="Khusnutdinova">Elza Khusnutdinova</name><affiliation wicri:level="1"><nlm:aff id="A60">Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa</wicri:regionArea></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation wicri:level="3"><nlm:aff id="A61">Department Molecular Medicine and Surgery, Karolinska Institutet, Stockholm</nlm:aff><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName><wicri:orgArea>Department Molecular Medicine and Surgery, Karolinska Institutet</wicri:orgArea></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation wicri:level="3"><nlm:aff id="A62">Department Onkologi-pathology, Karolinska Institutet, Stockholm</nlm:aff><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName><wicri:orgArea>Department Onkologi-pathology, Karolinska Institutet</wicri:orgArea></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation wicri:level="1"><nlm:aff id="A63">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio</wicri:regionArea></affiliation><affiliation><nlm:aff id="A64">Biocenter Kuopio, Kuopio Finland</nlm:aff><wicri:noCountry code="subfield">Kuopio Finland</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A65">Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Pathology, Kuopio University Hospital, Kuopio</wicri:regionArea></affiliation></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name><affiliation><nlm:aff id="A64">Biocenter Kuopio, Kuopio Finland</nlm:aff><wicri:noCountry code="subfield">Kuopio Finland</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A66">School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland, Kuopio</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A67">Department of Oncology, Kuopio University Hospital, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Oncology, Kuopio University Hospital, Kuopio</wicri:regionArea></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation wicri:level="1"><nlm:aff id="A63">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio</wicri:regionArea></affiliation><affiliation><nlm:aff id="A64">Biocenter Kuopio, Kuopio Finland</nlm:aff><wicri:noCountry code="subfield">Kuopio Finland</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A65">Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Pathology, Kuopio University Hospital, Kuopio</wicri:regionArea></affiliation></author><author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M" last="Hartikainen">Jaana M. Hartikainen</name><affiliation wicri:level="1"><nlm:aff id="A63">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio</wicri:regionArea></affiliation><affiliation><nlm:aff id="A64">Biocenter Kuopio, Kuopio Finland</nlm:aff><wicri:noCountry code="subfield">Kuopio Finland</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A65">Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Pathology, Kuopio University Hospital, Kuopio</wicri:regionArea></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation wicri:level="1"><nlm:aff id="A68">Vesalius Research Center [VRC], VIB, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center [VRC], VIB, Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Yesilyurt, Betul T" sort="Yesilyurt, Betul T" uniqKey="Yesilyurt B" first="Betul T." last="Yesilyurt">Betul T. Yesilyurt</name><affiliation wicri:level="1"><nlm:aff id="A68">Vesalius Research Center [VRC], VIB, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center [VRC], VIB, Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Floris, Giuseppe" sort="Floris, Giuseppe" uniqKey="Floris G" first="Giuseppe" last="Floris">Giuseppe Floris</name><affiliation wicri:level="1"><nlm:aff id="A69">Multidisciplinary Breast Center, University Hospital Gasthuisberg, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Multidisciplinary Breast Center, University Hospital Gasthuisberg, Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Leunen, Karin" sort="Leunen, Karin" uniqKey="Leunen K" first="Karin" last="Leunen">Karin Leunen</name><affiliation wicri:level="1"><nlm:aff id="A69">Multidisciplinary Breast Center, University Hospital Gasthuisberg, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Multidisciplinary Breast Center, University Hospital Gasthuisberg, Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation wicri:level="1"><nlm:aff id="A70">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan</wicri:regionArea></affiliation></author><author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name><affiliation wicri:level="1"><nlm:aff id="A71">Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan</wicri:regionArea></affiliation></author><author><name sortKey="Fortuzzi, Stefano" sort="Fortuzzi, Stefano" uniqKey="Fortuzzi S" first="Stefano" last="Fortuzzi">Stefano Fortuzzi</name><affiliation wicri:level="1"><nlm:aff id="A72">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation wicri:level="1"><nlm:aff id="A73">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy and IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy and IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J" last="Couch">Fergus J. Couch</name><affiliation wicri:level="1"><nlm:aff id="A74">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A75">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation wicri:level="1"><nlm:aff id="A74">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Stevens, Kristen" sort="Stevens, Kristen" uniqKey="Stevens K" first="Kristen" last="Stevens">Kristen Stevens</name><affiliation wicri:level="1"><nlm:aff id="A75">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Adam" sort="Lee, Adam" uniqKey="Lee A" first="Adam" last="Lee">Adam Lee</name><affiliation wicri:level="1"><nlm:aff id="A76">Department of Pharmacology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation wicri:level="1"><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A77">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation wicri:level="1"><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A77">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation wicri:level="1"><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A77">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name><affiliation wicri:level="1"><nlm:aff id="A78">Department of Anatomical Pathology, Alfred Hospital, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Anatomical Pathology, Alfred Hospital, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Aln S, Grethe Grenaker" sort="Aln S, Grethe Grenaker" uniqKey="Aln S G" first="Grethe Grenaker" last="Aln S">Grethe Grenaker Aln S</name><affiliation wicri:level="1"><nlm:aff id="A79">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo</wicri:regionArea></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation wicri:level="1"><nlm:aff id="A79">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A80">Institute for Clinical Medicine, Faculty of Medicine, UiO, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Institute for Clinical Medicine, Faculty of Medicine, UiO</wicri:regionArea></affiliation></author><author><name sortKey="B Rrensen Dale, Anne Lise" sort="B Rrensen Dale, Anne Lise" uniqKey="B Rrensen Dale A" first="Anne-Lise" last="B Rrensen-Dale">Anne-Lise B Rrensen-Dale</name><affiliation wicri:level="1"><nlm:aff id="A79">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A80">Institute for Clinical Medicine, Faculty of Medicine, UiO, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Institute for Clinical Medicine, Faculty of Medicine, UiO</wicri:regionArea></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name><affiliation wicri:level="1"><nlm:aff id="A81">Cancer Prevention Institute of California, Fremont, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Prevention Institute of California, Fremont, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A82">Stanford University School of Medicine, Stanford, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford University School of Medicine, Stanford, California</wicri:regionArea></affiliation></author><author><name sortKey="Miron, Alexander" sort="Miron, Alexander" uniqKey="Miron A" first="Alexander" last="Miron">Alexander Miron</name><affiliation wicri:level="1"><nlm:aff id="A83">Dana-Farber Cancer Institute, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dana-Farber Cancer Institute, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation wicri:level="1"><nlm:aff id="A84">Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu</wicri:regionArea></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation wicri:level="1"><nlm:aff id="A84">Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu</wicri:regionArea></affiliation></author><author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name><affiliation wicri:level="1"><nlm:aff id="A85">Department of Oncology, University of Oulu, Oulu University Hospital, Oulu, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Department of Oncology, University of Oulu, Oulu University Hospital, Oulu</wicri:regionArea></affiliation></author><author><name sortKey="Kauppila, Saila" sort="Kauppila, Saila" uniqKey="Kauppila S" first="Saila" last="Kauppila">Saila Kauppila</name><affiliation wicri:level="1"><nlm:aff id="A86">Department of Pathology, University of Oulu, Oulu University Hospital, Oulu, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Department of Pathology, University of Oulu, Oulu University Hospital, Oulu</wicri:regionArea></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="A87">Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital</nlm:aff><wicri:noCountry code="subfield">Mount Sinai Hospital</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A88">Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Molecular Genetics, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation wicri:level="1"><nlm:aff id="A89">Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation wicri:level="1"><nlm:aff id="A90">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A91">Department of Laboratory Medicine, and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Laboratory Medicine, and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation wicri:level="1"><nlm:aff id="A92">Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Genetics, Leiden University Medical Centre, Leiden</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A93">Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, Leiden University Medical Centre, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Van Asperen, Christie J" sort="Van Asperen, Christie J" uniqKey="Van Asperen C" first="Christie J." last="Van Asperen">Christie J. Van Asperen</name><affiliation wicri:level="1"><nlm:aff id="A94">Department of Clinical Genetics, Leiden University Medical Centre, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Leiden University Medical Centre, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Tollenaar, Rob A E M" sort="Tollenaar, Rob A E M" uniqKey="Tollenaar R" first="Rob A. E. M." last="Tollenaar">Rob A. E. M. Tollenaar</name><affiliation wicri:level="1"><nlm:aff id="A95">Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgery, Leiden University Medical Centre, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name><affiliation wicri:level="1"><nlm:aff id="A96">Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Figueroa, Jonine D" sort="Figueroa, Jonine D" uniqKey="Figueroa J" first="Jonine D" last="Figueroa">Jonine D. Figueroa</name><affiliation wicri:level="1"><nlm:aff id="A27">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name><affiliation wicri:level="1"><nlm:aff id="A4">Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A97">Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Epidemiology, Institute of Cancer Research, Sutton</wicri:regionArea></affiliation></author><author><name sortKey="Brinton, Louise" sort="Brinton, Louise" uniqKey="Brinton L" first="Louise" last="Brinton">Louise Brinton</name><affiliation wicri:level="1"><nlm:aff id="A27">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><affiliation wicri:level="1"><nlm:aff id="A98">Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw</wicri:regionArea></affiliation></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name><affiliation wicri:level="1"><nlm:aff id="A99">Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam,The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation wicri:level="1"><nlm:aff id="A100">Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Oldenburg, Rogier A" sort="Oldenburg, Rogier A" uniqKey="Oldenburg R" first="Rogier A." last="Oldenburg">Rogier A. Oldenburg</name><affiliation wicri:level="1"><nlm:aff id="A101">Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam,The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Van Den Ouweland, Ans M W" sort="Van Den Ouweland, Ans M W" uniqKey="Van Den Ouweland A" first="Ans M. W." last="Van Den Ouweland">Ans M. W. Van Den Ouweland</name><affiliation wicri:level="1"><nlm:aff id="A101">Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam,The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation wicri:level="1"><nlm:aff id="A102">Institute for Cancer Studies, Department of Oncology, University of Sheffield, Sheffield, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute for Cancer Studies, Department of Oncology, University of Sheffield, Sheffield</wicri:regionArea></affiliation></author><author><name sortKey="Reed, Malcolm Wr" sort="Reed, Malcolm Wr" uniqKey="Reed M" first="Malcolm Wr" last="Reed">Malcolm Wr Reed</name><affiliation wicri:level="1"><nlm:aff id="A103">Academic Unit of Surgical Oncology, Department of Oncology, University of Sheffield, Sheffield, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Academic Unit of Surgical Oncology, Department of Oncology, University of Sheffield, Sheffield</wicri:regionArea></affiliation></author><author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Jakubowska, Ania" sort="Jakubowska, Ania" uniqKey="Jakubowska A" first="Ania" last="Jakubowska">Ania Jakubowska</name><affiliation wicri:level="1"><nlm:aff id="A104">International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation wicri:level="1"><nlm:aff id="A104">International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea></affiliation></author><author><name sortKey="Jaworska, Katarzyna" sort="Jaworska, Katarzyna" uniqKey="Jaworska K" first="Katarzyna" last="Jaworska">Katarzyna Jaworska</name><affiliation wicri:level="1"><nlm:aff id="A104">International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea></affiliation></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><affiliation wicri:level="1"><nlm:aff id="A104">International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea></affiliation></author><author><name sortKey="Jones, Michael" sort="Jones, Michael" uniqKey="Jones M" first="Michael" last="Jones">Michael Jones</name><affiliation wicri:level="1"><nlm:aff id="A97">Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Epidemiology, Institute of Cancer Research, Sutton</wicri:regionArea></affiliation></author><author><name sortKey="Schoemaker, Minouk" sort="Schoemaker, Minouk" uniqKey="Schoemaker M" first="Minouk" last="Schoemaker">Minouk Schoemaker</name><affiliation wicri:level="1"><nlm:aff id="A97">Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Epidemiology, Institute of Cancer Research, Sutton</wicri:regionArea></affiliation></author><author><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name><affiliation wicri:level="1"><nlm:aff id="A2">Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London</wicri:regionArea></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation wicri:level="1"><nlm:aff id="A97">Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Epidemiology, Institute of Cancer Research, Sutton</wicri:regionArea></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation wicri:level="1"><nlm:aff id="A105">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name><affiliation wicri:level="1"><nlm:aff id="A105">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Muir, Kenneth R" sort="Muir, Kenneth R" uniqKey="Muir K" first="Kenneth R" last="Muir">Kenneth R. Muir</name><affiliation wicri:level="1"><nlm:aff id="A107">Warwick Medical School, Warwick University, Coventry, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Warwick Medical School, Warwick University, Coventry</wicri:regionArea></affiliation></author><author><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name><affiliation wicri:level="1"><nlm:aff id="A107">Warwick Medical School, Warwick University, Coventry, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Warwick Medical School, Warwick University, Coventry</wicri:regionArea></affiliation></author><author><name sortKey="Rattanamongkongul, Suthee" sort="Rattanamongkongul, Suthee" uniqKey="Rattanamongkongul S" first="Suthee" last="Rattanamongkongul">Suthee Rattanamongkongul</name><affiliation wicri:level="1"><nlm:aff id="A108">Department of Preventive Medicine, Srinakhrainwirot University, Ongkharak, Nakhon Nayok,Thailand</nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Department of Preventive Medicine, Srinakhrainwirot University, Ongkharak, Nakhon Nayok</wicri:regionArea></affiliation></author><author><name sortKey="Chaiwerawattana, Arkom" sort="Chaiwerawattana, Arkom" uniqKey="Chaiwerawattana A" first="Arkom" last="Chaiwerawattana">Arkom Chaiwerawattana</name><affiliation wicri:level="1"><nlm:aff id="A109">Department of Academic support, The National Cancer Institute of Thailand, Ministry of Public Health,Thailand</nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Department of Academic support, The National Cancer Institute of Thailand, Ministry of Public Health</wicri:regionArea></affiliation></author><author><name sortKey="Kang, Daehee" sort="Kang, Daehee" uniqKey="Kang D" first="Daehee" last="Kang">Daehee Kang</name><affiliation wicri:level="1"><nlm:aff id="A110">Seoul National University College of Medicine, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Seoul National University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Yoo, Keun Young" sort="Yoo, Keun Young" uniqKey="Yoo K" first="Keun-Young" last="Yoo">Keun-Young Yoo</name><affiliation wicri:level="1"><nlm:aff id="A110">Seoul National University College of Medicine, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Seoul National University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Noh, Dong Young" sort="Noh, Dong Young" uniqKey="Noh D" first="Dong-Young" last="Noh">Dong-Young Noh</name><affiliation wicri:level="1"><nlm:aff id="A110">Seoul National University College of Medicine, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Seoul National University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name><affiliation wicri:level="1"><nlm:aff id="A111">Institute of Biomedical Sciences, Academia Sinica, Taipei,Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Biomedical Sciences, Academia Sinica, Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Yu, Jyh Cherng" sort="Yu, Jyh Cherng" uniqKey="Yu J" first="Jyh-Cherng" last="Yu">Jyh-Cherng Yu</name><affiliation wicri:level="1"><nlm:aff id="A112">Department of Surgery, Tri-Service General Hospital, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Surgery, Tri-Service General Hospital, Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Wu, Pei Ei" sort="Wu, Pei Ei" uniqKey="Wu P" first="Pei-Ei" last="Wu">Pei-Ei Wu</name><affiliation wicri:level="1"><nlm:aff id="A111">Institute of Biomedical Sciences, Academia Sinica, Taipei,Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Biomedical Sciences, Academia Sinica, Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Hsiung, Chia Ni" sort="Hsiung, Chia Ni" uniqKey="Hsiung C" first="Chia-Ni" last="Hsiung">Chia-Ni Hsiung</name><affiliation wicri:level="1"><nlm:aff id="A111">Institute of Biomedical Sciences, Academia Sinica, Taipei,Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Biomedical Sciences, Academia Sinica, Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Perkins, Annie" sort="Perkins, Annie" uniqKey="Perkins A" first="Annie" last="Perkins">Annie Perkins</name><affiliation wicri:level="1"><nlm:aff id="A113">Against Breast Cancer Research Group, Department of Molecular and Applied Biosciences, University of Westminster, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Against Breast Cancer Research Group, Department of Molecular and Applied Biosciences, University of Westminster, London</wicri:regionArea></affiliation></author><author><name sortKey="Swann, Ruth" sort="Swann, Ruth" uniqKey="Swann R" first="Ruth" last="Swann">Ruth Swann</name><affiliation wicri:level="1"><nlm:aff id="A113">Against Breast Cancer Research Group, Department of Molecular and Applied Biosciences, University of Westminster, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Against Breast Cancer Research Group, Department of Molecular and Applied Biosciences, University of Westminster, London</wicri:regionArea></affiliation></author><author><name sortKey="Velentzis, Louiza" sort="Velentzis, Louiza" uniqKey="Velentzis L" first="Louiza" last="Velentzis">Louiza Velentzis</name><affiliation wicri:level="1"><nlm:aff id="A113">Against Breast Cancer Research Group, Department of Molecular and Applied Biosciences, University of Westminster, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Against Breast Cancer Research Group, Department of Molecular and Applied Biosciences, University of Westminster, London</wicri:regionArea></affiliation></author><author><name sortKey="Eccles, Diana M" sort="Eccles, Diana M" uniqKey="Eccles D" first="Diana M" last="Eccles">Diana M. Eccles</name><affiliation wicri:level="1"><nlm:aff id="A114">Faculty of Medicine, University of Southampton, Southampton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Medicine, University of Southampton, Southampton</wicri:regionArea></affiliation></author><author><name sortKey="Tapper, Will J" sort="Tapper, Will J" uniqKey="Tapper W" first="Will J" last="Tapper">Will J. Tapper</name><affiliation wicri:level="1"><nlm:aff id="A114">Faculty of Medicine, University of Southampton, Southampton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Medicine, University of Southampton, Southampton</wicri:regionArea></affiliation></author><author><name sortKey="Gerty, Susan M" sort="Gerty, Susan M" uniqKey="Gerty S" first="Susan M" last="Gerty">Susan M. Gerty</name><affiliation wicri:level="1"><nlm:aff id="A114">Faculty of Medicine, University of Southampton, Southampton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Medicine, University of Southampton, Southampton</wicri:regionArea></affiliation></author><author><name sortKey="Graham, Nikki J" sort="Graham, Nikki J" uniqKey="Graham N" first="Nikki J" last="Graham">Nikki J. Graham</name><affiliation wicri:level="1"><nlm:aff id="A114">Faculty of Medicine, University of Southampton, Southampton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Medicine, University of Southampton, Southampton</wicri:regionArea></affiliation></author><author><name sortKey="Ponder, Bruce A J" sort="Ponder, Bruce A J" uniqKey="Ponder B" first="Bruce A. J." last="Ponder">Bruce A. J. Ponder</name><affiliation wicri:level="1"><nlm:aff id="A115">Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A116">CRUK Cambridge Research Institute, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>CRUK Cambridge Research Institute, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation wicri:level="1"><nlm:aff id="A105">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation wicri:level="1"><nlm:aff id="A117">Centre National de Genotypage, Evry, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Centre National de Genotypage, Evry</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A118">Fondation Jean Dausset – CEPH, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Fondation Jean Dausset – CEPH, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><affiliation wicri:level="1"><nlm:aff id="A4">Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton</wicri:regionArea></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation wicri:level="1"><nlm:aff id="A7">Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London</wicri:regionArea></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F" last="Easton">Douglas F. Easton</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22267197</idno><idno type="pmc">3653403</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653403</idno><idno type="RBID">PMC:3653403</idno><idno type="doi">10.1038/ng.1049</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">002E10</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E10</idno><idno type="wicri:Area/Pmc/Curation">002C60</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002C60</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome-wide association analysis identifies three new breast cancer susceptibility loci</title><author><name sortKey="Ghoussaini, Maya" sort="Ghoussaini, Maya" uniqKey="Ghoussaini M" first="Maya" last="Ghoussaini">Maya Ghoussaini</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation wicri:level="1"><nlm:aff id="A2">Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London</wicri:regionArea></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation wicri:level="1"><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Turnbull, Clare" sort="Turnbull, Clare" uniqKey="Turnbull C" first="Clare" last="Turnbull">Clare Turnbull</name><affiliation wicri:level="1"><nlm:aff id="A4">Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K" last="Schmidt">Marjanka K. Schmidt</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Experimental Therapy, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Experimental Therapy, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Department of Epidemiology, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Dicks, Ed" sort="Dicks, Ed" uniqKey="Dicks E" first="Ed" last="Dicks">Ed Dicks</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation wicri:level="1"><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation wicri:level="1"><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Humphreys, Manjeet K" sort="Humphreys, Manjeet K" uniqKey="Humphreys M" first="Manjeet K" last="Humphreys">Manjeet K. Humphreys</name><affiliation wicri:level="1"><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Luccarini, Craig" sort="Luccarini, Craig" uniqKey="Luccarini C" first="Craig" last="Luccarini">Craig Luccarini</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Baynes, Caroline" sort="Baynes, Caroline" uniqKey="Baynes C" first="Caroline" last="Baynes">Caroline Baynes</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Conroy, Don" sort="Conroy, Don" uniqKey="Conroy D" first="Don" last="Conroy">Don Conroy</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Maranian, Melanie" sort="Maranian, Melanie" uniqKey="Maranian M" first="Melanie" last="Maranian">Melanie Maranian</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Ahmed, Shahana" sort="Ahmed, Shahana" uniqKey="Ahmed S" first="Shahana" last="Ahmed">Shahana Ahmed</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Driver, Kristy" sort="Driver, Kristy" uniqKey="Driver K" first="Kristy" last="Driver">Kristy Driver</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation wicri:level="1"><nlm:aff id="A2">Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London</wicri:regionArea></affiliation></author><author><name sortKey="Orr, Nicholas" sort="Orr, Nicholas" uniqKey="Orr N" first="Nicholas" last="Orr">Nicholas Orr</name><affiliation wicri:level="1"><nlm:aff id="A2">Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London</wicri:regionArea></affiliation></author><author><name sortKey="Silva, Isabel Dos Santos" sort="Silva, Isabel Dos Santos" uniqKey="Silva I" first="Isabel Dos Santos" last="Silva">Isabel Dos Santos Silva</name><affiliation wicri:level="1"><nlm:aff id="A7">Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London</wicri:regionArea></affiliation></author><author><name sortKey="Waisfisz, Quinten" sort="Waisfisz, Quinten" uniqKey="Waisfisz Q" first="Quinten" last="Waisfisz">Quinten Waisfisz</name><affiliation wicri:level="1"><nlm:aff id="A8">Department of Clinical Genetics, VU University Medical Center, section Oncogenetics, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, VU University Medical Center, section Oncogenetics, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Meijers Heijboer, Hanne" sort="Meijers Heijboer, Hanne" uniqKey="Meijers Heijboer H" first="Hanne" last="Meijers-Heijboer">Hanne Meijers-Heijboer</name><affiliation wicri:level="1"><nlm:aff id="A8">Department of Clinical Genetics, VU University Medical Center, section Oncogenetics, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, VU University Medical Center, section Oncogenetics, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Internal Medicine and Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine and Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Internal Medicine and Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine and Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation wicri:level="1"><nlm:aff id="A11">Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177</wicri:regionArea></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation wicri:level="1"><nlm:aff id="A11">Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177</wicri:regionArea></affiliation></author><author><name sortKey="Irwanto, Astrid" sort="Irwanto, Astrid" uniqKey="Irwanto A" first="Astrid" last="Irwanto">Astrid Irwanto</name><affiliation wicri:level="1"><nlm:aff id="A13">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation wicri:level="1"><nlm:aff id="A12">Human Genetics Division, Genome Institute of Singapore, Singapore 138672, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Human Genetics Division, Genome Institute of Singapore, Singapore 138672</wicri:regionArea></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation wicri:level="1"><nlm:aff id="A13">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation wicri:level="1"><nlm:aff id="A14">Department of Clinical Genetics, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Genetics, University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation wicri:level="1"><nlm:aff id="A15">Department of Oncology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Oncology, University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation wicri:level="1"><nlm:aff id="A16">Clinic of Gynaecology and Obstetrics, Division for Gynaecological Tumor-Genetics, Technische Universität München, München, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Clinic of Gynaecology and Obstetrics, Division for Gynaecological Tumor-Genetics, Technische Universität München, München</wicri:regionArea></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K" last="Schmutzler">Rita K. Schmutzler</name><affiliation wicri:level="1"><nlm:aff id="A17">Department of Obstetrics and Gynaecology, Division of Molecular Gynaeco-Oncology, University of Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynaecology, Division of Molecular Gynaeco-Oncology, University of Cologne</wicri:regionArea></affiliation></author><author><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name><affiliation wicri:level="1"><nlm:aff id="A18">Max Planck Institute of Psychiatry, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute of Psychiatry, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Lichtner, Peter" sort="Lichtner, Peter" uniqKey="Lichtner P" first="Peter" last="Lichtner">Peter Lichtner</name><affiliation wicri:level="1"><nlm:aff id="A19">Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation wicri:level="1"><nlm:aff id="A20">Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Hein, Rebecca" sort="Hein, Rebecca" uniqKey="Hein R" first="Rebecca" last="Hein">Rebecca Hein</name><affiliation wicri:level="1"><nlm:aff id="A20">Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A21">PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, University of Cologne, Cologne</wicri:regionArea></affiliation></author><author><name sortKey="Nickels, Stefan" sort="Nickels, Stefan" uniqKey="Nickels S" first="Stefan" last="Nickels">Stefan Nickels</name><affiliation wicri:level="1"><nlm:aff id="A20">Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation wicri:level="1"><nlm:aff id="A22">Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Hamburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Hamburg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A23">Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg</wicri:regionArea></affiliation></author><author><name sortKey="Tsimiklis, Helen" sort="Tsimiklis, Helen" uniqKey="Tsimiklis H" first="Helen" last="Tsimiklis">Helen Tsimiklis</name><affiliation wicri:level="1"><nlm:aff id="A24">Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name><affiliation wicri:level="1"><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Daniel" sort="Schmidt, Daniel" uniqKey="Schmidt D" first="Daniel" last="Schmidt">Daniel Schmidt</name><affiliation wicri:level="1"><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Bui, Minh" sort="Bui, Minh" uniqKey="Bui M" first="Minh" last="Bui">Minh Bui</name><affiliation wicri:level="1"><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation wicri:level="1"><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation wicri:level="1"><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Park, Daniel J" sort="Park, Daniel J" uniqKey="Park D" first="Daniel J" last="Park">Daniel J. Park</name><affiliation wicri:level="1"><nlm:aff id="A24">Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Southey, Melissa" sort="Southey, Melissa" uniqKey="Southey M" first="Melissa" last="Southey">Melissa Southey</name><affiliation wicri:level="1"><nlm:aff id="A24">Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name><affiliation wicri:level="1"><nlm:aff id="A26">Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="1"><nlm:aff id="A27">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Experimental Therapy, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Experimental Therapy, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Verhoef, Senno" sort="Verhoef, Senno" uniqKey="Verhoef S" first="Senno" last="Verhoef">Senno Verhoef</name><affiliation wicri:level="1"><nlm:aff id="A28">Department of Clinical Genetics, Family Cancer Clinic, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Family Cancer Clinic, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Hogervorst, Frans Bl" sort="Hogervorst, Frans Bl" uniqKey="Hogervorst F" first="Frans Bl" last="Hogervorst">Frans Bl Hogervorst</name><affiliation wicri:level="1"><nlm:aff id="A29">Department of Molecular Pathology, Family Cancer Clinic, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Molecular Pathology, Family Cancer Clinic, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation wicri:level="1"><nlm:aff id="A30">University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen</wicri:regionArea></affiliation></author><author><name sortKey="Lux, Michael P" sort="Lux, Michael P" uniqKey="Lux M" first="Michael P." last="Lux">Michael P. Lux</name><affiliation wicri:level="1"><nlm:aff id="A30">University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen</wicri:regionArea></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation wicri:level="1"><nlm:aff id="A30">University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen</wicri:regionArea></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation wicri:level="1"><nlm:aff id="A31">Institute of Human Genetics, Friedrich-Alexander University Erlangen Nuremberg, Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, Friedrich-Alexander University Erlangen Nuremberg, Erlangen</wicri:regionArea></affiliation></author><author><name sortKey="Sawyer, Elinor" sort="Sawyer, Elinor" uniqKey="Sawyer E" first="Elinor" last="Sawyer">Elinor Sawyer</name><affiliation wicri:level="1"><nlm:aff id="A32">Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ NHS Foundation Trust in partnership with King’s College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ NHS Foundation Trust in partnership with King’s College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation wicri:level="1"><nlm:aff id="A33">Welcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Welcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Kerin, Michael" sort="Kerin, Michael" uniqKey="Kerin M" first="Michael" last="Kerin">Michael Kerin</name><affiliation wicri:level="1"><nlm:aff id="A34">Clinical Science Institute, University Hospital Galway, Galway, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Clinical Science Institute, University Hospital Galway, Galway</wicri:regionArea></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><affiliation wicri:level="1"><nlm:aff id="A35">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A36">National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>National Center for Tumor Diseases, University of Heidelberg, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Schneeweiss, Andreas" sort="Schneeweiss, Andreas" uniqKey="Schneeweiss A" first="Andreas" last="Schneeweiss">Andreas Schneeweiss</name><affiliation wicri:level="1"><nlm:aff id="A35">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A36">National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>National Center for Tumor Diseases, University of Heidelberg, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Sohn, Christof" sort="Sohn, Christof" uniqKey="Sohn C" first="Christof" last="Sohn">Christof Sohn</name><affiliation wicri:level="1"><nlm:aff id="A35">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation wicri:level="1"><nlm:aff id="A35">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A37">Molecular Epidemiology Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Molecular Epidemiology Unit, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation wicri:level="1"><nlm:aff id="A38">Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Environmental epidemiology of cancer, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Environmental epidemiology of cancer, Villejuif</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A39">Université Paris-Sud, UMRS 1018, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Sud, UMRS 1018, Villejuif</wicri:regionArea></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation wicri:level="1"><nlm:aff id="A38">Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Environmental epidemiology of cancer, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Environmental epidemiology of cancer, Villejuif</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A39">Université Paris-Sud, UMRS 1018, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Sud, UMRS 1018, Villejuif</wicri:regionArea></affiliation></author><author><name sortKey="Cordina Duverger, Emilie" sort="Cordina Duverger, Emilie" uniqKey="Cordina Duverger E" first="Emilie" last="Cordina-Duverger">Emilie Cordina-Duverger</name><affiliation wicri:level="1"><nlm:aff id="A38">Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Environmental epidemiology of cancer, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Environmental epidemiology of cancer, Villejuif</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A39">Université Paris-Sud, UMRS 1018, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Sud, UMRS 1018, Villejuif</wicri:regionArea></affiliation></author><author><name sortKey="Menegaux, Florence" sort="Menegaux, Florence" uniqKey="Menegaux F" first="Florence" last="Menegaux">Florence Menegaux</name><affiliation wicri:level="1"><nlm:aff id="A38">Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Environmental epidemiology of cancer, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Environmental epidemiology of cancer, Villejuif</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A39">Université Paris-Sud, UMRS 1018, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Sud, UMRS 1018, Villejuif</wicri:regionArea></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E" last="Bojesen">Stig E. Bojesen</name><affiliation wicri:level="1"><nlm:aff id="A40">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A41">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G" last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation wicri:level="1"><nlm:aff id="A40">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A41">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Nielsen, Sune F" sort="Nielsen, Sune F" uniqKey="Nielsen S" first="Sune F" last="Nielsen">Sune F. Nielsen</name><affiliation wicri:level="1"><nlm:aff id="A40">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A41">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation wicri:level="1"><nlm:aff id="A42">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation wicri:level="1"><nlm:aff id="A43">Genetic & Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetic & Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Alonso, M Rosario" sort="Alonso, M Rosario" uniqKey="Alonso M" first="M. Rosario" last="Alonso">M. Rosario Alonso</name><affiliation wicri:level="1"><nlm:aff id="A44">Human Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Human Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name><affiliation wicri:level="1"><nlm:aff id="A44">Human Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Human Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name><affiliation wicri:level="1"><nlm:aff id="A45">Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation wicri:level="1"><nlm:aff id="A46">Department of Epidemiology, University of California Irvine, Irvine, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of California Irvine, Irvine, California</wicri:regionArea></affiliation></author><author><name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name><affiliation wicri:level="1"><nlm:aff id="A46">Department of Epidemiology, University of California Irvine, Irvine, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of California Irvine, Irvine, California</wicri:regionArea></affiliation></author><author><name sortKey="Bernstein, Leslie" sort="Bernstein, Leslie" uniqKey="Bernstein L" first="Leslie" last="Bernstein">Leslie Bernstein</name><affiliation wicri:level="1"><nlm:aff id="A47">City of Hope Cancer Centre, Duarte, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>City of Hope Cancer Centre, Duarte, California</wicri:regionArea></affiliation></author><author><name sortKey="Dur, Christina Clarke" sort="Dur, Christina Clarke" uniqKey="Dur C" first="Christina Clarke" last="Dur">Christina Clarke Dur</name><affiliation wicri:level="1"><nlm:aff id="A48">Cancer Prevention Institute of California, Fremont, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Prevention Institute of California, Fremont, California</wicri:regionArea></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="1"><nlm:aff id="A49">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center [DKFZ], Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center [DKFZ], Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Muller, Heiko" sort="Muller, Heiko" uniqKey="Muller H" first="Heiko" last="Müller">Heiko Müller</name><affiliation wicri:level="1"><nlm:aff id="A49">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center [DKFZ], Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center [DKFZ], Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation wicri:level="1"><nlm:aff id="A49">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center [DKFZ], Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center [DKFZ], Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name><affiliation wicri:level="1"><nlm:aff id="A50">Saarland Cancer Registry, Saarbrücken, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Saarland Cancer Registry, Saarbrücken</wicri:regionArea></affiliation></author><author><name sortKey="Justenhoven, Christina" sort="Justenhoven, Christina" uniqKey="Justenhoven C" first="Christina" last="Justenhoven">Christina Justenhoven</name><affiliation wicri:level="3"><nlm:aff id="A51">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart</nlm:aff><country>Allemagne</country><placeName><settlement type="city">Stuttgart</settlement><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Stuttgart</region></placeName><wicri:orgArea>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology</wicri:orgArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A52">University of Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation wicri:level="3"><nlm:aff id="A51">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart</nlm:aff><country>Allemagne</country><placeName><settlement type="city">Stuttgart</settlement><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Stuttgart</region></placeName><wicri:orgArea>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology</wicri:orgArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A52">University of Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><affiliation wicri:level="1"><nlm:aff id="A53">Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum</wicri:regionArea></affiliation></author><author><name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name><affiliation wicri:level="1"><nlm:aff id="A56">Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Ulm, Ulm</wicri:regionArea></affiliation></author><author><name sortKey="Eilber, Ursula" sort="Eilber, Ursula" uniqKey="Eilber U" first="Ursula" last="Eilber">Ursula Eilber</name><affiliation wicri:level="1"><nlm:aff id="A20">Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation wicri:level="1"><nlm:aff id="A57">Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover</wicri:regionArea></affiliation></author><author><name sortKey="Schurmann, Peter" sort="Schurmann, Peter" uniqKey="Schurmann P" first="Peter" last="Schürmann">Peter Schürmann</name><affiliation wicri:level="1"><nlm:aff id="A57">Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover</wicri:regionArea></affiliation></author><author><name sortKey="Bremer, Michael" sort="Bremer, Michael" uniqKey="Bremer M" first="Michael" last="Bremer">Michael Bremer</name><affiliation wicri:level="1"><nlm:aff id="A57">Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover</wicri:regionArea></affiliation></author><author><name sortKey="Hillemanns, Peter" sort="Hillemanns, Peter" uniqKey="Hillemanns P" first="Peter" last="Hillemanns">Peter Hillemanns</name><affiliation wicri:level="1"><nlm:aff id="A57">Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover</wicri:regionArea></affiliation></author><author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name><affiliation wicri:level="1"><nlm:aff id="A58">Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Radiation Oncology, Hannover Medical School, Hannover</wicri:regionArea></affiliation></author><author><name sortKey="Antonenkova, Natalia N" sort="Antonenkova, Natalia N" uniqKey="Antonenkova N" first="Natalia N." last="Antonenkova">Natalia N. Antonenkova</name><affiliation wicri:level="1"><nlm:aff id="A59">N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus</nlm:aff><country xml:lang="fr">Biélorussie</country><wicri:regionArea>N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk</wicri:regionArea></affiliation></author><author><name sortKey="Rogov, Yuri I" sort="Rogov, Yuri I" uniqKey="Rogov Y" first="Yuri I." last="Rogov">Yuri I. Rogov</name><affiliation wicri:level="1"><nlm:aff id="A59">N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus</nlm:aff><country xml:lang="fr">Biélorussie</country><wicri:regionArea>N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk</wicri:regionArea></affiliation></author><author><name sortKey="Karstens, Johann H" sort="Karstens, Johann H" uniqKey="Karstens J" first="Johann H." last="Karstens">Johann H. Karstens</name><affiliation wicri:level="1"><nlm:aff id="A58">Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Radiation Oncology, Hannover Medical School, Hannover</wicri:regionArea></affiliation></author><author><name sortKey="Bermisheva, Marina" sort="Bermisheva, Marina" uniqKey="Bermisheva M" first="Marina" last="Bermisheva">Marina Bermisheva</name><affiliation wicri:level="1"><nlm:aff id="A60">Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa</wicri:regionArea></affiliation></author><author><name sortKey="Prokofieva, Darya" sort="Prokofieva, Darya" uniqKey="Prokofieva D" first="Darya" last="Prokofieva">Darya Prokofieva</name><affiliation wicri:level="1"><nlm:aff id="A60">Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa</wicri:regionArea></affiliation></author><author><name sortKey="Khusnutdinova, Elza" sort="Khusnutdinova, Elza" uniqKey="Khusnutdinova E" first="Elza" last="Khusnutdinova">Elza Khusnutdinova</name><affiliation wicri:level="1"><nlm:aff id="A60">Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa</wicri:regionArea></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation wicri:level="3"><nlm:aff id="A61">Department Molecular Medicine and Surgery, Karolinska Institutet, Stockholm</nlm:aff><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName><wicri:orgArea>Department Molecular Medicine and Surgery, Karolinska Institutet</wicri:orgArea></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation wicri:level="3"><nlm:aff id="A62">Department Onkologi-pathology, Karolinska Institutet, Stockholm</nlm:aff><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName><wicri:orgArea>Department Onkologi-pathology, Karolinska Institutet</wicri:orgArea></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation wicri:level="1"><nlm:aff id="A63">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio</wicri:regionArea></affiliation><affiliation><nlm:aff id="A64">Biocenter Kuopio, Kuopio Finland</nlm:aff><wicri:noCountry code="subfield">Kuopio Finland</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A65">Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Pathology, Kuopio University Hospital, Kuopio</wicri:regionArea></affiliation></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name><affiliation><nlm:aff id="A64">Biocenter Kuopio, Kuopio Finland</nlm:aff><wicri:noCountry code="subfield">Kuopio Finland</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A66">School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland, Kuopio</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A67">Department of Oncology, Kuopio University Hospital, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Oncology, Kuopio University Hospital, Kuopio</wicri:regionArea></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation wicri:level="1"><nlm:aff id="A63">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio</wicri:regionArea></affiliation><affiliation><nlm:aff id="A64">Biocenter Kuopio, Kuopio Finland</nlm:aff><wicri:noCountry code="subfield">Kuopio Finland</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A65">Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Pathology, Kuopio University Hospital, Kuopio</wicri:regionArea></affiliation></author><author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M" last="Hartikainen">Jaana M. Hartikainen</name><affiliation wicri:level="1"><nlm:aff id="A63">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio</wicri:regionArea></affiliation><affiliation><nlm:aff id="A64">Biocenter Kuopio, Kuopio Finland</nlm:aff><wicri:noCountry code="subfield">Kuopio Finland</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A65">Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Pathology, Kuopio University Hospital, Kuopio</wicri:regionArea></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation wicri:level="1"><nlm:aff id="A68">Vesalius Research Center [VRC], VIB, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center [VRC], VIB, Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Yesilyurt, Betul T" sort="Yesilyurt, Betul T" uniqKey="Yesilyurt B" first="Betul T." last="Yesilyurt">Betul T. Yesilyurt</name><affiliation wicri:level="1"><nlm:aff id="A68">Vesalius Research Center [VRC], VIB, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center [VRC], VIB, Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Floris, Giuseppe" sort="Floris, Giuseppe" uniqKey="Floris G" first="Giuseppe" last="Floris">Giuseppe Floris</name><affiliation wicri:level="1"><nlm:aff id="A69">Multidisciplinary Breast Center, University Hospital Gasthuisberg, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Multidisciplinary Breast Center, University Hospital Gasthuisberg, Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Leunen, Karin" sort="Leunen, Karin" uniqKey="Leunen K" first="Karin" last="Leunen">Karin Leunen</name><affiliation wicri:level="1"><nlm:aff id="A69">Multidisciplinary Breast Center, University Hospital Gasthuisberg, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Multidisciplinary Breast Center, University Hospital Gasthuisberg, Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation wicri:level="1"><nlm:aff id="A70">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan</wicri:regionArea></affiliation></author><author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name><affiliation wicri:level="1"><nlm:aff id="A71">Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan</wicri:regionArea></affiliation></author><author><name sortKey="Fortuzzi, Stefano" sort="Fortuzzi, Stefano" uniqKey="Fortuzzi S" first="Stefano" last="Fortuzzi">Stefano Fortuzzi</name><affiliation wicri:level="1"><nlm:aff id="A72">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation wicri:level="1"><nlm:aff id="A73">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy and IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy and IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J" last="Couch">Fergus J. Couch</name><affiliation wicri:level="1"><nlm:aff id="A74">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A75">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation wicri:level="1"><nlm:aff id="A74">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Stevens, Kristen" sort="Stevens, Kristen" uniqKey="Stevens K" first="Kristen" last="Stevens">Kristen Stevens</name><affiliation wicri:level="1"><nlm:aff id="A75">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Adam" sort="Lee, Adam" uniqKey="Lee A" first="Adam" last="Lee">Adam Lee</name><affiliation wicri:level="1"><nlm:aff id="A76">Department of Pharmacology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation wicri:level="1"><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A77">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation wicri:level="1"><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A77">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation wicri:level="1"><nlm:aff id="A25">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A77">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name><affiliation wicri:level="1"><nlm:aff id="A78">Department of Anatomical Pathology, Alfred Hospital, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Anatomical Pathology, Alfred Hospital, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Aln S, Grethe Grenaker" sort="Aln S, Grethe Grenaker" uniqKey="Aln S G" first="Grethe Grenaker" last="Aln S">Grethe Grenaker Aln S</name><affiliation wicri:level="1"><nlm:aff id="A79">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo</wicri:regionArea></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation wicri:level="1"><nlm:aff id="A79">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A80">Institute for Clinical Medicine, Faculty of Medicine, UiO, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Institute for Clinical Medicine, Faculty of Medicine, UiO</wicri:regionArea></affiliation></author><author><name sortKey="B Rrensen Dale, Anne Lise" sort="B Rrensen Dale, Anne Lise" uniqKey="B Rrensen Dale A" first="Anne-Lise" last="B Rrensen-Dale">Anne-Lise B Rrensen-Dale</name><affiliation wicri:level="1"><nlm:aff id="A79">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A80">Institute for Clinical Medicine, Faculty of Medicine, UiO, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Institute for Clinical Medicine, Faculty of Medicine, UiO</wicri:regionArea></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name><affiliation wicri:level="1"><nlm:aff id="A81">Cancer Prevention Institute of California, Fremont, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Prevention Institute of California, Fremont, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A82">Stanford University School of Medicine, Stanford, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford University School of Medicine, Stanford, California</wicri:regionArea></affiliation></author><author><name sortKey="Miron, Alexander" sort="Miron, Alexander" uniqKey="Miron A" first="Alexander" last="Miron">Alexander Miron</name><affiliation wicri:level="1"><nlm:aff id="A83">Dana-Farber Cancer Institute, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dana-Farber Cancer Institute, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation wicri:level="1"><nlm:aff id="A84">Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu</wicri:regionArea></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation wicri:level="1"><nlm:aff id="A84">Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu</wicri:regionArea></affiliation></author><author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name><affiliation wicri:level="1"><nlm:aff id="A85">Department of Oncology, University of Oulu, Oulu University Hospital, Oulu, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Department of Oncology, University of Oulu, Oulu University Hospital, Oulu</wicri:regionArea></affiliation></author><author><name sortKey="Kauppila, Saila" sort="Kauppila, Saila" uniqKey="Kauppila S" first="Saila" last="Kauppila">Saila Kauppila</name><affiliation wicri:level="1"><nlm:aff id="A86">Department of Pathology, University of Oulu, Oulu University Hospital, Oulu, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Department of Pathology, University of Oulu, Oulu University Hospital, Oulu</wicri:regionArea></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="A87">Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital</nlm:aff><wicri:noCountry code="subfield">Mount Sinai Hospital</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A88">Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Molecular Genetics, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation wicri:level="1"><nlm:aff id="A89">Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation wicri:level="1"><nlm:aff id="A90">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A91">Department of Laboratory Medicine, and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Laboratory Medicine, and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation wicri:level="1"><nlm:aff id="A92">Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Genetics, Leiden University Medical Centre, Leiden</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A93">Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, Leiden University Medical Centre, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Van Asperen, Christie J" sort="Van Asperen, Christie J" uniqKey="Van Asperen C" first="Christie J." last="Van Asperen">Christie J. Van Asperen</name><affiliation wicri:level="1"><nlm:aff id="A94">Department of Clinical Genetics, Leiden University Medical Centre, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Leiden University Medical Centre, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Tollenaar, Rob A E M" sort="Tollenaar, Rob A E M" uniqKey="Tollenaar R" first="Rob A. E. M." last="Tollenaar">Rob A. E. M. Tollenaar</name><affiliation wicri:level="1"><nlm:aff id="A95">Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgery, Leiden University Medical Centre, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name><affiliation wicri:level="1"><nlm:aff id="A96">Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Figueroa, Jonine D" sort="Figueroa, Jonine D" uniqKey="Figueroa J" first="Jonine D" last="Figueroa">Jonine D. Figueroa</name><affiliation wicri:level="1"><nlm:aff id="A27">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name><affiliation wicri:level="1"><nlm:aff id="A4">Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A97">Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Epidemiology, Institute of Cancer Research, Sutton</wicri:regionArea></affiliation></author><author><name sortKey="Brinton, Louise" sort="Brinton, Louise" uniqKey="Brinton L" first="Louise" last="Brinton">Louise Brinton</name><affiliation wicri:level="1"><nlm:aff id="A27">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><affiliation wicri:level="1"><nlm:aff id="A98">Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw</wicri:regionArea></affiliation></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name><affiliation wicri:level="1"><nlm:aff id="A99">Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam,The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation wicri:level="1"><nlm:aff id="A100">Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Oldenburg, Rogier A" sort="Oldenburg, Rogier A" uniqKey="Oldenburg R" first="Rogier A." last="Oldenburg">Rogier A. Oldenburg</name><affiliation wicri:level="1"><nlm:aff id="A101">Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam,The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Van Den Ouweland, Ans M W" sort="Van Den Ouweland, Ans M W" uniqKey="Van Den Ouweland A" first="Ans M. W." last="Van Den Ouweland">Ans M. W. Van Den Ouweland</name><affiliation wicri:level="1"><nlm:aff id="A101">Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam,The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation wicri:level="1"><nlm:aff id="A102">Institute for Cancer Studies, Department of Oncology, University of Sheffield, Sheffield, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute for Cancer Studies, Department of Oncology, University of Sheffield, Sheffield</wicri:regionArea></affiliation></author><author><name sortKey="Reed, Malcolm Wr" sort="Reed, Malcolm Wr" uniqKey="Reed M" first="Malcolm Wr" last="Reed">Malcolm Wr Reed</name><affiliation wicri:level="1"><nlm:aff id="A103">Academic Unit of Surgical Oncology, Department of Oncology, University of Sheffield, Sheffield, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Academic Unit of Surgical Oncology, Department of Oncology, University of Sheffield, Sheffield</wicri:regionArea></affiliation></author><author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Jakubowska, Ania" sort="Jakubowska, Ania" uniqKey="Jakubowska A" first="Ania" last="Jakubowska">Ania Jakubowska</name><affiliation wicri:level="1"><nlm:aff id="A104">International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation wicri:level="1"><nlm:aff id="A104">International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea></affiliation></author><author><name sortKey="Jaworska, Katarzyna" sort="Jaworska, Katarzyna" uniqKey="Jaworska K" first="Katarzyna" last="Jaworska">Katarzyna Jaworska</name><affiliation wicri:level="1"><nlm:aff id="A104">International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea></affiliation></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><affiliation wicri:level="1"><nlm:aff id="A104">International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea></affiliation></author><author><name sortKey="Jones, Michael" sort="Jones, Michael" uniqKey="Jones M" first="Michael" last="Jones">Michael Jones</name><affiliation wicri:level="1"><nlm:aff id="A97">Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Epidemiology, Institute of Cancer Research, Sutton</wicri:regionArea></affiliation></author><author><name sortKey="Schoemaker, Minouk" sort="Schoemaker, Minouk" uniqKey="Schoemaker M" first="Minouk" last="Schoemaker">Minouk Schoemaker</name><affiliation wicri:level="1"><nlm:aff id="A97">Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Epidemiology, Institute of Cancer Research, Sutton</wicri:regionArea></affiliation></author><author><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name><affiliation wicri:level="1"><nlm:aff id="A2">Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London</wicri:regionArea></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation wicri:level="1"><nlm:aff id="A97">Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Epidemiology, Institute of Cancer Research, Sutton</wicri:regionArea></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation wicri:level="1"><nlm:aff id="A105">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name><affiliation wicri:level="1"><nlm:aff id="A105">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Muir, Kenneth R" sort="Muir, Kenneth R" uniqKey="Muir K" first="Kenneth R" last="Muir">Kenneth R. Muir</name><affiliation wicri:level="1"><nlm:aff id="A107">Warwick Medical School, Warwick University, Coventry, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Warwick Medical School, Warwick University, Coventry</wicri:regionArea></affiliation></author><author><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name><affiliation wicri:level="1"><nlm:aff id="A107">Warwick Medical School, Warwick University, Coventry, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Warwick Medical School, Warwick University, Coventry</wicri:regionArea></affiliation></author><author><name sortKey="Rattanamongkongul, Suthee" sort="Rattanamongkongul, Suthee" uniqKey="Rattanamongkongul S" first="Suthee" last="Rattanamongkongul">Suthee Rattanamongkongul</name><affiliation wicri:level="1"><nlm:aff id="A108">Department of Preventive Medicine, Srinakhrainwirot University, Ongkharak, Nakhon Nayok,Thailand</nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Department of Preventive Medicine, Srinakhrainwirot University, Ongkharak, Nakhon Nayok</wicri:regionArea></affiliation></author><author><name sortKey="Chaiwerawattana, Arkom" sort="Chaiwerawattana, Arkom" uniqKey="Chaiwerawattana A" first="Arkom" last="Chaiwerawattana">Arkom Chaiwerawattana</name><affiliation wicri:level="1"><nlm:aff id="A109">Department of Academic support, The National Cancer Institute of Thailand, Ministry of Public Health,Thailand</nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Department of Academic support, The National Cancer Institute of Thailand, Ministry of Public Health</wicri:regionArea></affiliation></author><author><name sortKey="Kang, Daehee" sort="Kang, Daehee" uniqKey="Kang D" first="Daehee" last="Kang">Daehee Kang</name><affiliation wicri:level="1"><nlm:aff id="A110">Seoul National University College of Medicine, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Seoul National University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Yoo, Keun Young" sort="Yoo, Keun Young" uniqKey="Yoo K" first="Keun-Young" last="Yoo">Keun-Young Yoo</name><affiliation wicri:level="1"><nlm:aff id="A110">Seoul National University College of Medicine, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Seoul National University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Noh, Dong Young" sort="Noh, Dong Young" uniqKey="Noh D" first="Dong-Young" last="Noh">Dong-Young Noh</name><affiliation wicri:level="1"><nlm:aff id="A110">Seoul National University College of Medicine, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Seoul National University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name><affiliation wicri:level="1"><nlm:aff id="A111">Institute of Biomedical Sciences, Academia Sinica, Taipei,Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Biomedical Sciences, Academia Sinica, Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Yu, Jyh Cherng" sort="Yu, Jyh Cherng" uniqKey="Yu J" first="Jyh-Cherng" last="Yu">Jyh-Cherng Yu</name><affiliation wicri:level="1"><nlm:aff id="A112">Department of Surgery, Tri-Service General Hospital, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Surgery, Tri-Service General Hospital, Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Wu, Pei Ei" sort="Wu, Pei Ei" uniqKey="Wu P" first="Pei-Ei" last="Wu">Pei-Ei Wu</name><affiliation wicri:level="1"><nlm:aff id="A111">Institute of Biomedical Sciences, Academia Sinica, Taipei,Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Biomedical Sciences, Academia Sinica, Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Hsiung, Chia Ni" sort="Hsiung, Chia Ni" uniqKey="Hsiung C" first="Chia-Ni" last="Hsiung">Chia-Ni Hsiung</name><affiliation wicri:level="1"><nlm:aff id="A111">Institute of Biomedical Sciences, Academia Sinica, Taipei,Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Biomedical Sciences, Academia Sinica, Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Perkins, Annie" sort="Perkins, Annie" uniqKey="Perkins A" first="Annie" last="Perkins">Annie Perkins</name><affiliation wicri:level="1"><nlm:aff id="A113">Against Breast Cancer Research Group, Department of Molecular and Applied Biosciences, University of Westminster, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Against Breast Cancer Research Group, Department of Molecular and Applied Biosciences, University of Westminster, London</wicri:regionArea></affiliation></author><author><name sortKey="Swann, Ruth" sort="Swann, Ruth" uniqKey="Swann R" first="Ruth" last="Swann">Ruth Swann</name><affiliation wicri:level="1"><nlm:aff id="A113">Against Breast Cancer Research Group, Department of Molecular and Applied Biosciences, University of Westminster, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Against Breast Cancer Research Group, Department of Molecular and Applied Biosciences, University of Westminster, London</wicri:regionArea></affiliation></author><author><name sortKey="Velentzis, Louiza" sort="Velentzis, Louiza" uniqKey="Velentzis L" first="Louiza" last="Velentzis">Louiza Velentzis</name><affiliation wicri:level="1"><nlm:aff id="A113">Against Breast Cancer Research Group, Department of Molecular and Applied Biosciences, University of Westminster, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Against Breast Cancer Research Group, Department of Molecular and Applied Biosciences, University of Westminster, London</wicri:regionArea></affiliation></author><author><name sortKey="Eccles, Diana M" sort="Eccles, Diana M" uniqKey="Eccles D" first="Diana M" last="Eccles">Diana M. Eccles</name><affiliation wicri:level="1"><nlm:aff id="A114">Faculty of Medicine, University of Southampton, Southampton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Medicine, University of Southampton, Southampton</wicri:regionArea></affiliation></author><author><name sortKey="Tapper, Will J" sort="Tapper, Will J" uniqKey="Tapper W" first="Will J" last="Tapper">Will J. Tapper</name><affiliation wicri:level="1"><nlm:aff id="A114">Faculty of Medicine, University of Southampton, Southampton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Medicine, University of Southampton, Southampton</wicri:regionArea></affiliation></author><author><name sortKey="Gerty, Susan M" sort="Gerty, Susan M" uniqKey="Gerty S" first="Susan M" last="Gerty">Susan M. Gerty</name><affiliation wicri:level="1"><nlm:aff id="A114">Faculty of Medicine, University of Southampton, Southampton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Medicine, University of Southampton, Southampton</wicri:regionArea></affiliation></author><author><name sortKey="Graham, Nikki J" sort="Graham, Nikki J" uniqKey="Graham N" first="Nikki J" last="Graham">Nikki J. Graham</name><affiliation wicri:level="1"><nlm:aff id="A114">Faculty of Medicine, University of Southampton, Southampton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Medicine, University of Southampton, Southampton</wicri:regionArea></affiliation></author><author><name sortKey="Ponder, Bruce A J" sort="Ponder, Bruce A J" uniqKey="Ponder B" first="Bruce A. J." last="Ponder">Bruce A. J. Ponder</name><affiliation wicri:level="1"><nlm:aff id="A115">Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A116">CRUK Cambridge Research Institute, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>CRUK Cambridge Research Institute, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation wicri:level="1"><nlm:aff id="A105">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation wicri:level="1"><nlm:aff id="A117">Centre National de Genotypage, Evry, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Centre National de Genotypage, Evry</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A118">Fondation Jean Dausset – CEPH, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Fondation Jean Dausset – CEPH, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><affiliation wicri:level="1"><nlm:aff id="A4">Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton</wicri:regionArea></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation wicri:level="1"><nlm:aff id="A7">Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London</wicri:regionArea></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F" last="Easton">Douglas F. Easton</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Breast cancer is the most common cancer among women. To date, 22 common breast cancer susceptibility loci have been identified accounting for ~ 8% of the heritability of the disease. We followed up 72 promising associations from two independent Genome Wide Association Studies (GWAS) in ~70,000 cases and ~68,000 controls from 41 case-control studies and nine breast cancer GWAS. We identified three new breast cancer risk loci on 12p11 (rs10771399; <italic>P</italic>=2.7 × 10<sup>−35</sup>), 12q24 (rs1292011; <italic>P</italic>=4.3×10<sup>−19</sup>) and 21q21 (rs2823093; <italic>P</italic>=1.1×10<sup>−12</sup>). SNP rs10771399 was associated with similar relative risks for both estrogen receptor (ER)-negative and ER-positive breast cancer, whereas the other two loci were associated only with ER-positive disease. Two of the loci lie in regions that contain strong plausible candidate genes: <italic>PTHLH</italic> (12p11) plays a crucial role in mammary gland development and the establishment of bone metastasis in breast cancer, while <italic>NRIP1</italic> (21q21) encodes an ER co-factor and has a role in the regulation of breast cancer cell growth.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kamangar, F" uniqKey="Kamangar F">F Kamangar</name></author><author><name sortKey="Dores, Gm" uniqKey="Dores G">GM Dores</name></author><author><name sortKey="Anderson, Wf" uniqKey="Anderson W">WF Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lichtenstein, P" uniqKey="Lichtenstein P">P Lichtenstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peto, J" uniqKey="Peto J">J Peto</name></author><author><name sortKey="Mack, Tm" uniqKey="Mack T">TM 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article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<pmc-dir>properties manuscript</pmc-dir>
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rid="A102">102</xref></contrib><contrib contrib-type="author"><name><surname>Reed</surname><given-names>Malcolm WR</given-names></name><xref ref-type="aff" rid="A103">103</xref></contrib><contrib contrib-type="author"><name><surname>Shah</surname><given-names>Mitul</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Jakubowska</surname><given-names>Ania</given-names></name><xref ref-type="aff" rid="A104">104</xref></contrib><contrib contrib-type="author"><name><surname>Lubinski</surname><given-names>Jan</given-names></name><xref ref-type="aff" rid="A104">104</xref></contrib><contrib contrib-type="author"><name><surname>Jaworska</surname><given-names>Katarzyna</given-names></name><xref ref-type="aff" rid="A104">104</xref></contrib><contrib contrib-type="author"><name><surname>Durda</surname><given-names>Katarzyna</given-names></name><xref ref-type="aff" rid="A104">104</xref></contrib><contrib contrib-type="author"><name><surname>Jones</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="A97">97</xref></contrib><contrib contrib-type="author"><name><surname>Schoemaker</surname><given-names>Minouk</given-names></name><xref ref-type="aff" rid="A97">97</xref></contrib><contrib contrib-type="author"><name><surname>Ashworth</surname><given-names>Alan</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Swerdlow</surname><given-names>Anthony</given-names></name><xref ref-type="aff" rid="A97">97</xref></contrib><contrib contrib-type="author"><name><surname>Beesley</surname><given-names>Jonathan</given-names></name><xref ref-type="aff" rid="A105">105</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Xiaoqing</given-names></name><xref ref-type="aff" rid="A105">105</xref></contrib><contrib contrib-type="author"><collab>kConFab Investigators</collab><xref 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contrib-type="author"><name><surname>Perkins</surname><given-names>Annie</given-names></name><xref ref-type="aff" rid="A113">113</xref></contrib><contrib contrib-type="author"><name><surname>Swann</surname><given-names>Ruth</given-names></name><xref ref-type="aff" rid="A113">113</xref></contrib><contrib contrib-type="author"><name><surname>Velentzis</surname><given-names>Louiza</given-names></name><xref ref-type="aff" rid="A113">113</xref></contrib><contrib contrib-type="author"><name><surname>Eccles</surname><given-names>Diana M</given-names></name><xref ref-type="aff" rid="A114">114</xref></contrib><contrib contrib-type="author"><name><surname>Tapper</surname><given-names>Will J</given-names></name><xref ref-type="aff" rid="A114">114</xref></contrib><contrib contrib-type="author"><name><surname>Gerty</surname><given-names>Susan M</given-names></name><xref ref-type="aff" rid="A114">114</xref></contrib><contrib contrib-type="author"><name><surname>Graham</surname><given-names>Nikki 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J.</given-names></name><xref ref-type="aff" rid="A115">115</xref><xref ref-type="aff" rid="A116">116</xref></contrib><contrib contrib-type="author"><name><surname>Chenevix-Trench</surname><given-names>Georgia</given-names></name><xref ref-type="aff" rid="A105">105</xref></contrib><contrib contrib-type="author"><name><surname>Pharoah</surname><given-names>Paul D.P.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Lathrop</surname><given-names>Mark</given-names></name><xref ref-type="aff" rid="A117">117</xref><xref ref-type="aff" rid="A118">118</xref></contrib><contrib contrib-type="author"><name><surname>Dunning</surname><given-names>Alison M.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Rahman</surname><given-names>Nazneen</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Peto</surname><given-names>Julian</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas F</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A3">3</xref></contrib></contrib-group><aff id="A1"><label>1</label>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</aff><aff id="A2"><label>2</label>Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</aff><aff id="A3"><label>3</label>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</aff><aff id="A4"><label>4</label>Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK</aff><aff id="A5"><label>5</label>Department of Experimental Therapy, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</aff><aff id="A6"><label>6</label>Department of Epidemiology, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</aff><aff id="A7"><label>7</label>Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK.</aff><aff id="A8"><label>8</label>Department of Clinical Genetics, VU University Medical Center, section Oncogenetics, Amsterdam, The Netherlands</aff><aff id="A9"><label>9</label>Department of Internal Medicine and Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</aff><aff id="A10"><label>10</label>Netherlands Collaborative Group on Hereditary Breast and Ovarian Cancer</aff><aff id="A11"><label>11</label>Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</aff><aff id="A12"><label>12</label>Human Genetics Division, Genome Institute of Singapore, Singapore 138672, Singapore</aff><aff id="A13"><label>13</label>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</aff><aff id="A14"><label>14</label>Department of Clinical Genetics, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</aff><aff id="A15"><label>15</label>Department of Oncology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</aff><aff id="A16"><label>16</label>Clinic of Gynaecology and Obstetrics, Division for Gynaecological Tumor-Genetics, Technische Universität München, München, Germany</aff><aff id="A17"><label>17</label>Department of Obstetrics and Gynaecology, Division of Molecular Gynaeco-Oncology, University of Cologne, Germany</aff><aff id="A18"><label>18</label>Max Planck Institute of Psychiatry, Munich, Germany</aff><aff id="A19"><label>19</label>Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</aff><aff id="A20"><label>20</label>Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany</aff><aff id="A21"><label>21</label>PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany</aff><aff id="A22"><label>22</label>Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Hamburg, Germany</aff><aff id="A23"><label>23</label>Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</aff><aff id="A24"><label>24</label>Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Australia</aff><aff id="A25"><label>25</label>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Australia</aff><aff id="A26"><label>26</label>Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</aff><aff id="A27"><label>27</label>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA</aff><aff id="A28"><label>28</label>Department of Clinical Genetics, Family Cancer Clinic, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</aff><aff id="A29"><label>29</label>Department of Molecular Pathology, Family Cancer Clinic, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</aff><aff id="A30"><label>30</label>University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany</aff><aff id="A31"><label>31</label>Institute of Human Genetics, Friedrich-Alexander University Erlangen Nuremberg, Erlangen, Germany</aff><aff id="A32"><label>32</label>Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ NHS Foundation Trust in partnership with King’s College London, London, UK</aff><aff id="A33"><label>33</label>Welcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, UK</aff><aff id="A34"><label>34</label>Clinical Science Institute, University Hospital Galway, Galway, Ireland</aff><aff id="A35"><label>35</label>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</aff><aff id="A36"><label>36</label>National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</aff><aff id="A37"><label>37</label>Molecular Epidemiology Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A38"><label>38</label>Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Environmental epidemiology of cancer, Villejuif, France</aff><aff id="A39"><label>39</label>Université Paris-Sud, UMRS 1018, Villejuif, France</aff><aff id="A40"><label>40</label>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</aff><aff id="A41"><label>41</label>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</aff><aff id="A42"><label>42</label>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</aff><aff id="A43"><label>43</label>Genetic & Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</aff><aff id="A44"><label>44</label>Human Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</aff><aff id="A45"><label>45</label>Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</aff><aff id="A46"><label>46</label>Department of Epidemiology, University of California Irvine, Irvine, California, USA</aff><aff id="A47"><label>47</label>City of Hope Cancer Centre, Duarte, California, USA</aff><aff id="A48"><label>48</label>Cancer Prevention Institute of California, Fremont, California, USA</aff><aff id="A49"><label>49</label>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center [DKFZ], Heidelberg, Germany</aff><aff id="A50"><label>50</label>Saarland Cancer Registry, Saarbrücken, Germany</aff><aff id="A51"><label>51</label>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart</aff><aff id="A52"><label>52</label>University of Tübingen, Germany</aff><aff id="A53"><label>53</label>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum, Germany</aff><aff id="A54"><label>54</label>Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany</aff><aff id="A55"><label>55</label>Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany</aff><aff id="A56"><label>56</label>Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany</aff><aff id="A57"><label>57</label>Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</aff><aff id="A58"><label>58</label>Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</aff><aff id="A59"><label>59</label>N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus</aff><aff id="A60"><label>60</label>Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</aff><aff id="A61"><label>61</label>Department Molecular Medicine and Surgery, Karolinska Institutet, Stockholm</aff><aff id="A62"><label>62</label>Department Onkologi-pathology, Karolinska Institutet, Stockholm</aff><aff id="A63"><label>63</label>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</aff><aff id="A64"><label>64</label>Biocenter Kuopio, Kuopio Finland</aff><aff id="A65"><label>65</label>Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</aff><aff id="A66"><label>66</label>School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland, Kuopio, Finland</aff><aff id="A67"><label>67</label>Department of Oncology, Kuopio University Hospital, Kuopio, Finland</aff><aff id="A68"><label>68</label>Vesalius Research Center [VRC], VIB, Leuven, Belgium</aff><aff id="A69"><label>69</label>Multidisciplinary Breast Center, University Hospital Gasthuisberg, Leuven, Belgium</aff><aff id="A70"><label>70</label>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</aff><aff id="A71"><label>71</label>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy</aff><aff id="A72"><label>72</label>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</aff><aff id="A73"><label>73</label>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy and IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</aff><aff id="A74"><label>74</label>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</aff><aff id="A75"><label>75</label>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</aff><aff id="A76"><label>76</label>Department of Pharmacology, Mayo Clinic, Rochester, Minnesota, USA</aff><aff id="A77"><label>77</label>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</aff><aff id="A78"><label>78</label>Department of Anatomical Pathology, Alfred Hospital, Melbourne, Australia</aff><aff id="A79"><label>79</label>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</aff><aff id="A80"><label>80</label>Institute for Clinical Medicine, Faculty of Medicine, UiO, Norway</aff><aff id="A81"><label>81</label>Cancer Prevention Institute of California, Fremont, California, USA</aff><aff id="A82"><label>82</label>Stanford University School of Medicine, Stanford, California, USA</aff><aff id="A83"><label>83</label>Dana-Farber Cancer Institute, Boston, Massachusetts, USA</aff><aff id="A84"><label>84</label>Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu, Finland.</aff><aff id="A85"><label>85</label>Department of Oncology, University of Oulu, Oulu University Hospital, Oulu, Finland.</aff><aff id="A86"><label>86</label>Department of Pathology, University of Oulu, Oulu University Hospital, Oulu, Finland.</aff><aff id="A87"><label>87</label>Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital</aff><aff id="A88"><label>88</label>Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</aff><aff id="A89"><label>89</label>Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada</aff><aff id="A90"><label>90</label>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada</aff><aff id="A91"><label>91</label>Department of Laboratory Medicine, and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, Ontario, Canada</aff><aff id="A92"><label>92</label>Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands</aff><aff id="A93"><label>93</label>Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands</aff><aff id="A94"><label>94</label>Department of Clinical Genetics, Leiden University Medical Centre, Leiden, The Netherlands</aff><aff id="A95"><label>95</label>Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands</aff><aff id="A96"><label>96</label>Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</aff><aff id="A97"><label>97</label>Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom</aff><aff id="A98"><label>98</label>Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland</aff><aff id="A99"><label>99</label>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam,The Netherlands</aff><aff id="A100"><label>100</label>Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="A101"><label>101</label>Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam,The Netherlands</aff><aff id="A102"><label>102</label>Institute for Cancer Studies, Department of Oncology, University of Sheffield, Sheffield, UK</aff><aff id="A103"><label>103</label>Academic Unit of Surgical Oncology, Department of Oncology, University of Sheffield, Sheffield, UK</aff><aff id="A104"><label>104</label>International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</aff><aff id="A105"><label>105</label>Queensland Institute of Medical Research, Brisbane, Australia</aff><aff id="A106"><label>106</label>Peter MacCallum Cancer Center, Melbourne, Australia</aff><aff id="A107"><label>107</label>Warwick Medical School, Warwick University, Coventry, UK</aff><aff id="A108"><label>108</label>Department of Preventive Medicine, Srinakhrainwirot University, Ongkharak, Nakhon Nayok,Thailand</aff><aff id="A109"><label>109</label>Department of Academic support, The National Cancer Institute of Thailand, Ministry of Public Health,Thailand</aff><aff id="A110"><label>110</label>Seoul National University College of Medicine, Seoul, Korea</aff><aff id="A111"><label>111</label>Institute of Biomedical Sciences, Academia Sinica, Taipei,Taiwan</aff><aff id="A112"><label>112</label>Department of Surgery, Tri-Service General Hospital, Taipei, Taiwan</aff><aff id="A113"><label>113</label>Against Breast Cancer Research Group, Department of Molecular and Applied Biosciences, University of Westminster, London, UK</aff><aff id="A114"><label>114</label>Faculty of Medicine, University of Southampton, Southampton, UK</aff><aff id="A115"><label>115</label>Department of Oncology, University of Cambridge, Cambridge, UK</aff><aff id="A116"><label>116</label>CRUK Cambridge Research Institute, Cambridge, UK</aff><aff id="A117"><label>117</label>Centre National de Genotypage, Evry, France.</aff><aff id="A118"><label>118</label>Fondation Jean Dausset – CEPH, Paris, France.</aff><pub-date pub-type="nihms-submitted"><day>6</day><month>2</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>22</day><month>1</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>14</day><month>5</month><year>2013</year></pub-date><volume>44</volume><issue>3</issue><fpage>312</fpage><lpage>318</lpage><permissions><license><license-p>Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:
<uri xlink:type="simple" xlink:href="http://www.nature.com/authors/editorial_policies/license.html#terms">http://www.nature.com/authors/editorial_policies/license.html#terms</uri></license-p></license></permissions><abstract><p id="P1">Breast cancer is the most common cancer among women. To date, 22 common breast cancer susceptibility loci have been identified accounting for ~ 8% of the heritability of the disease. We followed up 72 promising associations from two independent Genome Wide Association Studies (GWAS) in ~70,000 cases and ~68,000 controls from 41 case-control studies and nine breast cancer GWAS. We identified three new breast cancer risk loci on 12p11 (rs10771399; <italic>P</italic>=2.7 × 10<sup>−35</sup>), 12q24 (rs1292011; <italic>P</italic>=4.3×10<sup>−19</sup>) and 21q21 (rs2823093; <italic>P</italic>=1.1×10<sup>−12</sup>). SNP rs10771399 was associated with similar relative risks for both estrogen receptor (ER)-negative and ER-positive breast cancer, whereas the other two loci were associated only with ER-positive disease. Two of the loci lie in regions that contain strong plausible candidate genes: <italic>PTHLH</italic> (12p11) plays a crucial role in mammary gland development and the establishment of bone metastasis in breast cancer, while <italic>NRIP1</italic> (21q21) encodes an ER co-factor and has a role in the regulation of breast cancer cell growth.</p></abstract></article-meta></front><floats-group><fig id="F1" orientation="portrait" position="float"><label>Figure 1</label><caption><p>Forest plots for the 3 SNPs showing evidence of association with breast cancer. Squares represent the estimated per-allele odds ratio (OR) for individual studies. The area of square is inversely proportional to the precise of the estimate. Diamonds represent the summary OR estimates for the subgroups indicated. Horizontal lines represent 95% confidence limits.</p></caption><graphic xlink:href="emss-40160-f0001"></graphic></fig><fig id="F2" orientation="portrait" position="float"><label>Figures 2a, b and c</label><caption><p>Association plots for the three new breast cancer susceptibility loci at (a) 12p11 (b) 12q24 and (c) 21q21 drawn using the SNAP software35 <sup><xref ref-type="bibr" rid="R68">68</xref></sup>. Genotyped and imputed SNPs are plotted based on their chromosomal position in build 36 on the X axis and their overall <italic>P</italic> values (as −log10 values) from the UK2 and BBCS GWAS on the Y axis. For each region, the most strongly associated SNP is represented by a diamond. The intensity of the red shading reflects the strength of correlation (r<sup>2</sup>) between the best SNP and the other SNPs in the region. Genes present in the region (if any) are indicated in green.</p></caption><graphic xlink:href="emss-40160-f0002"></graphic><graphic xlink:href="emss-40160-f0003"></graphic><graphic xlink:href="emss-40160-f0004"></graphic></fig><table-wrap id="T1" position="float" orientation="portrait"><label>Table 1</label><table frame="box" rules="all"><thead><tr><th align="left" valign="top" rowspan="1" colspan="1">SNP</th><th align="left" valign="top" rowspan="1" colspan="1">Chromosome<break></break>Position<xref ref-type="table-fn" rid="TFN1">1</xref></th><th align="left" valign="top" rowspan="1" colspan="1">Alleles<xref ref-type="table-fn" rid="TFN2">2</xref></th><th align="left" valign="top" rowspan="1" colspan="1">MAF</th><th align="left" valign="top" rowspan="1" colspan="1">Stage</th><th align="left" valign="top" rowspan="1" colspan="1">Per-allele<break></break>OR<break></break>(95%CI)<xref ref-type="table-fn" rid="TFN3">3</xref></th><th align="left" valign="top" rowspan="1" colspan="1">P</th><th align="left" valign="top" rowspan="1" colspan="1">Combined P</th></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">rs10771399</td><td align="left" valign="top" rowspan="1" colspan="1">12p11<break></break>28046347</td><td align="left" valign="top" rowspan="1" colspan="1">AG</td><td align="left" valign="top" rowspan="1" colspan="1">0.12</td><td align="left" valign="top" rowspan="1" colspan="1">UK2</td><td align="left" valign="top" rowspan="1" colspan="1">0.79<break></break>(0.71-0.87)</td><td align="left" valign="top" rowspan="1" colspan="1">3.1×10<sup>−6</sup></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">0.11</td><td align="left" valign="top" rowspan="1" colspan="1">BBCS</td><td align="left" valign="top" rowspan="1" colspan="1">0.84<break></break>(0.74-0.96)</td><td align="left" valign="top" rowspan="1" colspan="1">.008</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">0.10</td><td align="left" valign="top" rowspan="1" colspan="1">Other GWAS</td><td align="left" valign="top" rowspan="1" colspan="1">0.83<break></break>(0.75-0.91)</td><td align="left" valign="top" rowspan="1" colspan="1">5.7×10<sup>−5</sup></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">0.12</td><td align="left" valign="top" rowspan="1" colspan="1">BCAC<break></break>replication</td><td align="left" valign="top" rowspan="1" colspan="1">0.85<break></break>(0.83-0.88)</td><td align="left" valign="top" rowspan="1" colspan="1">3.3×10<sup>−27</sup></td><td align="left" valign="top" rowspan="1" colspan="1">2.7×10<sup>−35</sup></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs1292011</td><td align="left" valign="top" rowspan="1" colspan="1">12q24<break></break>114320905</td><td align="left" valign="top" rowspan="1" colspan="1">AG</td><td align="left" valign="top" rowspan="1" colspan="1">0.41</td><td align="left" valign="top" rowspan="1" colspan="1">UK2</td><td align="left" valign="top" rowspan="1" colspan="1">0.88<break></break>(0.83-0.94)</td><td align="left" valign="top" rowspan="1" colspan="1">5.8×10<sup>−5</sup></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">0.42</td><td align="left" valign="top" rowspan="1" colspan="1">BBCS</td><td align="left" valign="top" rowspan="1" colspan="1">0.95<break></break>(0.88-1.03)</td><td align="left" valign="top" rowspan="1" colspan="1">0.23</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">0.40</td><td align="left" valign="top" rowspan="1" colspan="1">Other GWAS</td><td align="left" valign="top" rowspan="1" colspan="1">0.91<break></break>(0.86-0.96)</td><td align="left" valign="top" rowspan="1" colspan="1">.0008</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">0.41</td><td align="left" valign="top" rowspan="1" colspan="1">BCAC<break></break>replication</td><td align="left" valign="top" rowspan="1" colspan="1">0.92<break></break>(0.91-0.94)</td><td align="left" valign="top" rowspan="1" colspan="1">6.2×10<sup>−14</sup></td><td align="left" valign="top" rowspan="1" colspan="1">4.3×10<sup>−19</sup></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs2823093</td><td align="left" valign="top" rowspan="1" colspan="1">21q21<break></break>15442703</td><td align="left" valign="top" rowspan="1" colspan="1">GA</td><td align="left" valign="top" rowspan="1" colspan="1">0.26</td><td align="left" valign="top" rowspan="1" colspan="1">UK2</td><td align="left" valign="top" rowspan="1" colspan="1">0.96<break></break>(0.89-1.03)</td><td align="left" valign="top" rowspan="1" colspan="1">0.21</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">0.26</td><td align="left" valign="top" rowspan="1" colspan="1">BBCS</td><td align="left" valign="top" rowspan="1" colspan="1">0.88<break></break>(0.76-0.92)</td><td align="left" valign="top" rowspan="1" colspan="1">.00013</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">0.26</td><td align="left" valign="top" rowspan="1" colspan="1">Other GWAS</td><td align="left" valign="top" rowspan="1" colspan="1">0.91<break></break>(0.85-0.97)</td><td align="left" valign="top" rowspan="1" colspan="1">.0032</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">0.27</td><td align="left" valign="top" rowspan="1" colspan="1">BCAC<break></break>replication</td><td align="left" valign="top" rowspan="1" colspan="1">0.94<break></break>(0.92-0.96)</td><td align="left" valign="top" rowspan="1" colspan="1">1.7×10<sup>−9</sup></td><td align="left" valign="top" rowspan="1" colspan="1">1.1×10<sup>−12</sup></td></tr></tbody></table><table-wrap-foot><fn id="TFN1"><label>1</label><p id="P21">Build 36</p></fn><fn id="TFN2"><label>2</label><p id="P22">Minor allele listed second</p></fn><fn 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