Low-Intensity Repetitive Transcranial Magnetic Stimulation Improves Abnormal Visual Cortical Circuit Topography and Upregulates BDNF in Mice
Identifieur interne : 001852 ( Pmc/Curation ); précédent : 001851; suivant : 001853Low-Intensity Repetitive Transcranial Magnetic Stimulation Improves Abnormal Visual Cortical Circuit Topography and Upregulates BDNF in Mice
Auteurs : Kalina Makowiecki ; Alan R. Harvey ; Rachel M. Sherrard [France] ; Jennifer RodgerSource :
- The Journal of Neuroscience [ 0270-6474 ] ; 2014.
Abstract
Repetitive transcranial magnetic stimulation (rTMS) is increasingly used as a treatment for neurological and psychiatric disorders. Although the induced field is focused on a target region during rTMS, adjacent areas also receive stimulation at a lower intensity and the contribution of this perifocal stimulation to network-wide effects is poorly defined. Here, we examined low-intensity rTMS (LI-rTMS)-induced changes on a model neural network using the visual systems of normal (C57Bl/6J wild-type,
Url:
DOI: 10.1523/JNEUROSCI.0723-14.2014
PubMed: 25100609
PubMed Central: 4122806
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Kalina Makowiecki<affiliation><nlm:aff wicri:cut=", and" id="aff1">Experimental and Regenerative Neuroscience, School of Animal Biology</nlm:aff>
<wicri:noCountry code="subfield">School of Animal Biology</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff wicri:cut=", and" id="aff1">Experimental and Regenerative Neuroscience, School of Animal Biology</nlm:aff>
<wicri:noCountry code="subfield">School of Animal Biology</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff wicri:cut=", and" id="aff2">School of Anatomy, Physiology and Human Biology, The University of Western Australia, Crawley, Western Australia 6009</nlm:aff>
<wicri:noCountry code="subfield">Western Australia 6009</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff wicri:cut=", and" id="aff2">School of Anatomy, Physiology and Human Biology, The University of Western Australia, Crawley, Western Australia 6009</nlm:aff>
<wicri:noCountry code="subfield">Western Australia 6009</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff wicri:cut=", and" id="aff1">Experimental and Regenerative Neuroscience, School of Animal Biology</nlm:aff>
<wicri:noCountry code="subfield">School of Animal Biology</wicri:noCountry>
</affiliation>
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<front><div type="abstract" xml:lang="en"><p>Repetitive transcranial magnetic stimulation (rTMS) is increasingly used as a treatment for neurological and psychiatric disorders. Although the induced field is focused on a target region during rTMS, adjacent areas also receive stimulation at a lower intensity and the contribution of this perifocal stimulation to network-wide effects is poorly defined. Here, we examined low-intensity rTMS (LI-rTMS)-induced changes on a model neural network using the visual systems of normal (C57Bl/6J wild-type, <italic>n</italic>
= 22) and ephrin-A2A5<sup>−/−</sup>
(<italic>n</italic>
= 22) mice, the latter possessing visuotopic anomalies. Mice were treated with LI-rTMS or sham (handling control) daily for 14 d, then fluorojade and fluororuby were injected into visual cortex. The distribution of dorsal LGN (dLGN) neurons and corticotectal terminal zones (TZs) was mapped and disorder defined by comparing their actual location with that predicted by injection sites. In the afferent geniculocortical projection, LI-rTMS decreased the abnormally high dispersion of retrogradely labeled neurons in the dLGN of ephrin-A2A5<sup>−/−</sup>
mice, indicating geniculocortical map refinement. In the corticotectal efferents, LI-rTMS improved topography of the most abnormal TZs in ephrin-A2A5<sup>−/−</sup>
mice without altering topographically normal TZs. To investigate a possible molecular mechanism for LI-rTMS-induced structural plasticity, we measured brain derived neurotrophic factor (BDNF) in the visual cortex and superior colliculus after single and multiple stimulations. BDNF was upregulated after a single stimulation for all groups, but only sustained in the superior colliculus of ephrin-A2A5<sup>−/−</sup>
mice. Our results show that LI-rTMS upregulates BDNF, promoting a plastic environment conducive to beneficial reorganization of abnormal cortical circuits, information that has important implications for clinical rTMS.</p>
</div>
</front>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Neurosci</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Neurosci</journal-id>
<journal-id journal-id-type="hwp">jneuro</journal-id>
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<title-group><article-title>Low-Intensity Repetitive Transcranial Magnetic Stimulation Improves Abnormal Visual Cortical Circuit Topography and Upregulates BDNF in Mice</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Makowiecki</surname>
<given-names>Kalina</given-names>
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<xref ref-type="aff" rid="aff1"><sup>1</sup>
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<xref ref-type="aff" rid="aff1"><sup>1</sup>
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<xref ref-type="aff" rid="aff2"><sup>2</sup>
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<contrib contrib-type="author"><name><surname>Sherrard</surname>
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<xref ref-type="aff" rid="aff3"><sup>3</sup>
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<contrib contrib-type="author" corresp="yes"><name><surname>Rodger</surname>
<given-names>Jennifer</given-names>
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<xref ref-type="aff" rid="aff1"><sup>1</sup>
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<aff id="aff1"><sup>1</sup>
Experimental and Regenerative Neuroscience, School of Animal Biology, and</aff>
<aff id="aff2"><sup>2</sup>
School of Anatomy, Physiology and Human Biology, The University of Western Australia, Crawley, Western Australia 6009, and</aff>
<aff id="aff3"><sup>3</sup>
Sorbonne Universités, Pierre and Marie Curie University of Paris 06 and Centre National de la Recherche Scientifique, Institut de Biologie Paris Seine, UMR8256 Biological Adaptation and Ageing, F-75005 Paris, France</aff>
</contrib-group>
<author-notes><corresp>Correspondence should be addressed to Jennifer Rodger,
<addr-line>Experimental and Regenerative Neuroscience M317, School of Animal Biology, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009.</addr-line>
<email>jennifer.rodger@uwa.edu.au</email>
</corresp>
<fn fn-type="con"><p>Author contributions: K.M., A.R.H., R.M.S., and J.R. designed research; K.M. and J.R. performed research; K.M., A.R.H., and J.R. analyzed data; K.M., A.R.H., R.M.S., and J.R. wrote the paper.</p>
</fn>
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<abstract><p>Repetitive transcranial magnetic stimulation (rTMS) is increasingly used as a treatment for neurological and psychiatric disorders. Although the induced field is focused on a target region during rTMS, adjacent areas also receive stimulation at a lower intensity and the contribution of this perifocal stimulation to network-wide effects is poorly defined. Here, we examined low-intensity rTMS (LI-rTMS)-induced changes on a model neural network using the visual systems of normal (C57Bl/6J wild-type, <italic>n</italic>
= 22) and ephrin-A2A5<sup>−/−</sup>
(<italic>n</italic>
= 22) mice, the latter possessing visuotopic anomalies. Mice were treated with LI-rTMS or sham (handling control) daily for 14 d, then fluorojade and fluororuby were injected into visual cortex. The distribution of dorsal LGN (dLGN) neurons and corticotectal terminal zones (TZs) was mapped and disorder defined by comparing their actual location with that predicted by injection sites. In the afferent geniculocortical projection, LI-rTMS decreased the abnormally high dispersion of retrogradely labeled neurons in the dLGN of ephrin-A2A5<sup>−/−</sup>
mice, indicating geniculocortical map refinement. In the corticotectal efferents, LI-rTMS improved topography of the most abnormal TZs in ephrin-A2A5<sup>−/−</sup>
mice without altering topographically normal TZs. To investigate a possible molecular mechanism for LI-rTMS-induced structural plasticity, we measured brain derived neurotrophic factor (BDNF) in the visual cortex and superior colliculus after single and multiple stimulations. BDNF was upregulated after a single stimulation for all groups, but only sustained in the superior colliculus of ephrin-A2A5<sup>−/−</sup>
mice. Our results show that LI-rTMS upregulates BDNF, promoting a plastic environment conducive to beneficial reorganization of abnormal cortical circuits, information that has important implications for clinical rTMS.</p>
</abstract>
<kwd-group><kwd>corticotectal projection</kwd>
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