AustralieFrV1, Pmc, Curation, bibRecord, 001417

A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population

Identifieur interne : 001417 ( Pmc/Curation ); précédent : 001416; suivant : 001418

A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population

Auteurs : Antonis C. Antoniou [Royaume-Uni] ; Xianshu Wang [États-Unis] ; Zachary S. Fredericksen [États-Unis] ; Lesley Mcguffog [Royaume-Uni] ; Robert Tarrell [États-Unis] ; Olga M. Sinilnikova [France] ; Sue Healey [Australie] ; Jonathan Morrison [Royaume-Uni] ; Christiana Kartsonaki [Royaume-Uni] ; Timothy Lesnick [États-Unis] ; Maya Ghoussaini [Australie] ; Daniel Barrowdale [Royaume-Uni] ; Susan Peock [Royaume-Uni] ; Margaret Cook [Royaume-Uni] ; Clare Oliver [Royaume-Uni] ; Debra Frost [Royaume-Uni] ; Diana Eccles [Royaume-Uni] ; D Gareth Evans [Royaume-Uni] ; Ros Eeles [Royaume-Uni] ; Louise Izatt [Royaume-Uni] ; Carol Chu [Royaume-Uni] ; Fiona Douglas [Royaume-Uni] ; Joan Paterson [Royaume-Uni] ; Dominique Stoppa-Lyonnet [France] ; Claude Houdayer [France] ; Sylvie Mazoyer [France] ; Sophie Giraud [France] ; Christine Lasset [France] ; Audrey Remenieras [France] ; Olivier Caron [France] ; Agnès Hardouin [France] ; Pascaline Berthet [France] ; Frans B L. Hogervorst [Pays-Bas] ; Matti A. Rookus [Pays-Bas] ; Agnes Jager [Pays-Bas] ; Ans Van Den Ouweland [Pays-Bas] ; Nicoline Hoogerbrugge [Pays-Bas] ; Rob B. Van Der Luijt [Pays-Bas] ; Hanne Meijers-Heijboer [Pays-Bas] ; Encarna B G Mez García [Pays-Bas] ; Peter Devilee [Pays-Bas] ; Maaike P G. Vreeswijk [Pays-Bas] ; Jan Lubinski [Pologne] ; Anna Jakubowska [Pologne] ; Jacek Gronwald [Pologne] ; Tomasz Huzarski [Pologne] ; Tomasz Byrski [Pologne] ; Bohdan G Rski [Pologne] ; Cezary Cybulski [Pologne] ; Amanda B. Spurdle [Australie] ; Helene Holland [Australie] ; David E. Goldgar [États-Unis] ; Esther M. John [États-Unis] ; John L. Hopper [Australie] ; Melissa Southey [Australie] ; Saundra S. Buys [États-Unis] ; Mary B. Daly [États-Unis] ; Mary-Beth Terry [États-Unis] ; Rita K. Schmutzler [Allemagne] ; Barbara Wappenschmidt [Allemagne] ; Christoph Engel [Allemagne] ; Alfons Meindl [Allemagne] ; Sabine Preisler-Adams [Allemagne] ; Norbert Arnold [Allemagne] ; Dieter Niederacher [Allemagne] ; Christian Sutter [Allemagne] ; Susan M. Domchek [États-Unis] ; Katherine L. Nathanson [États-Unis] ; Timothy Rebbeck [États-Unis] ; Joanne L. Blum [États-Unis] ; Marion Piedmonte [États-Unis] ; Gustavo C. Rodriguez [États-Unis] ; Katie Wakeley [États-Unis] ; John F. Boggess [États-Unis] ; Jack Basil [États-Unis] ; Stephanie V. Blank [États-Unis] ; Eitan Friedman [Israël] ; Bella Kaufman [Israël] ; Yael Laitman [Israël] ; Roni Milgrom [Israël] ; Irene L. Andrulis [Canada] ; Gord Glendon [Canada] ; Hilmi Ozcelik [Canada] ; Tomas Kirchhoff [États-Unis] ; Joseph Vijai [États-Unis] ; Mia M. Gaudet [États-Unis] ; David Altshuler [États-Unis] ; Candace Guiducci [États-Unis] ; Niklas Loman [Suède] ; Katja Harbst [Suède] ; Johanna Rantala [Suède] ; Hans Ehrencrona [Suède] ; Anne-Marie Gerdes [Danemark] ; Mads Thomassen [Danemark] ; Lone Sunde [Danemark] ; Paolo Peterlongo [Italie] ; Siranoush Manoukian [Italie] ; Bernardo Bonanni [Italie] ; Alessandra Viel [Italie] ; Paolo Radice [Italie] ; Trinidad Caldes [Espagne] ; Miguel De La Hoya [Italie] ; Christian F. Singer [Autriche] ; Anneliese Fink-Retter [Autriche] ; Mark H. Greene [États-Unis] ; Phuong L. Mai [États-Unis] ; Jennifer T. Loud [États-Unis] ; Lucia Guidugli [États-Unis] ; Noralane M. Lindor [États-Unis] ; Thomas V O. Hansen [Danemark] ; Finn C. Nielsen [Danemark] ; Ignacio Blanco [Espagne] ; Conxi Lazaro [Espagne] ; Judy Garber [États-Unis] ; Susan J. Ramus [Royaume-Uni] ; Simon A. Gayther [Royaume-Uni] ; Catherine Phelan [Canada] ; Stephen Narod [États-Unis] ; Csilla I. Szabo [États-Unis] ; Javier Benitez [Espagne] ; Ana Osorio [Espagne] ; Heli Nevanlinna [Finlande] ; Tuomas Heikkinen [Finlande] ; Maria A. Caligo [Italie] ; Mary S. Beattie [États-Unis] ; Ute Hamann [Allemagne] ; Andrew K. Godwin [États-Unis] ; Marco Montagna [Italie] ; Cinzia Casella [Italie] ; Susan L. Neuhausen [États-Unis] ; Beth Y. Karlan [États-Unis] ; Nadine Tung [États-Unis] ; Amanda E. Toland [États-Unis] ; Jeffrey Weitzel [États-Unis] ; Olofunmilayo Olopade [États-Unis] ; Jacques Simard [Canada] ; Penny Soucy [Canada] ; Wendy S. Rubinstein [États-Unis] ; Adalgeir Arason [Islande] ; Gad Rennert [Australie] ; Nicholas G. Martin [Israël] ; Grant W. Montgomery [Israël] ; Jenny Chang-Claude [Allemagne] ; Dieter Flesch-Janys [Allemagne] ; Hiltrud Brauch [Allemagne] ; Gianluca Severi [Australie] ; Laura Baglietto [Australie] ; Angela Cox [Royaume-Uni] ; Simon S. Cross [Royaume-Uni] ; Penelope Miron [États-Unis] ; Sue M. Gerty [Royaume-Uni] ; William Tapper [Royaume-Uni] ; Drakoulis Yannoukakos [Grèce] ; George Fountzilas [Grèce] ; Peter A. Fasching [États-Unis] ; Matthias W. Beckmann [Allemagne] ; Isabel Dos Santos Silva [Royaume-Uni] ; Julian Peto [Royaume-Uni] ; Diether Lambrechts [Belgique] ; Robert Paridaens [Belgique] ; Thomas Rüdiger [Allemagne] ; Asta Försti [Allemagne, Suède] ; Robert Winqvist [Finlande] ; Katri Pylk S [Finlande] ; Robert B. Diasio [États-Unis] ; Adam M. Lee [États-Unis] ; Jeanette Eckel-Passow [États-Unis] ; Celine Vachon [États-Unis] ; Fiona Blows [Royaume-Uni] ; Kristy Driver [Royaume-Uni] ; Alison Dunning [Royaume-Uni] ; Paul P D. Pharoah [Royaume-Uni] ; Kenneth Offit [Canada] ; V Shane Pankratz [États-Unis] ; Hakon Hakonarson [États-Unis] ; Georgia Chenevix-Trench [Australie] ; Douglas F. Easton [Royaume-Uni] ; Fergus J. Couch [États-Unis]

Source :

Nature genetics [ 1061-4036 ] ; 2010.

RBID : PMC:3130795

Abstract

Germline BRCA1 mutations predispose to breast cancer. To identify genetic modifiers of this risk, we performed a genome-wide association study in 1,193 individuals with BRCA1 mutations who were diagnosed with invasive breast cancer under age 40 and 1,190 BRCA1 carriers without breast cancer diagnosis over age 35. We took forward 96 SNPs for replication in another 5,986 BRCA1 carriers (2,974 individuals with breast cancer and 3,012 unaffected individuals). Five SNPs on 19p13 were associated with breast cancer risk (P_trend = 2.3 × 10⁻⁹ to P_trend = 3.9 × 10⁻⁷), two of which showed independent associations (rs8170, hazard ratio (HR) = 1.26, 95% CI 1.17–1.35; rs2363956 HR = 0.84, 95% CI 0.80–0.89). Genotyping these SNPs in 6,800 population-based breast cancer cases and 6,613 controls identified a similar association with estrogen receptor–negative breast cancer (rs2363956 per-allele odds ratio (OR) = 0.83, 95% CI 0.75–0.92, P_trend = 0.0003) and an association with estrogen receptor–positive disease in the opposite direction (OR = 1.07, 95% CI 1.01–1.14, P_trend = 0.016). The five SNPs were also associated with triple-negative breast cancer in a separate study of 2,301 triple-negative cases and 3,949 controls (P_trend = 1 × 10⁻⁷ to P_trend = 8 × 10⁻⁵; rs2363956 per-allele OR = 0.80, 95% CI 0.74–0.87, P_trend = 1.1 × 10⁻⁷).

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130795

DOI: 10.1038/ng.669
PubMed: 20852631
PubMed Central: 3130795

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<author><name sortKey="Paterson, Joan" sort="Paterson, Joan" uniqKey="Paterson J" first="Joan" last="Paterson">Joan Paterson</name>
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<author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name>
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<author><name sortKey="Houdayer, Claude" sort="Houdayer, Claude" uniqKey="Houdayer C" first="Claude" last="Houdayer">Claude Houdayer</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea> INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes, Paris</wicri:regionArea>
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<author><name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea> Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon</wicri:regionArea>
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<author><name sortKey="Giraud, Sophie" sort="Giraud, Sophie" uniqKey="Giraud S" first="Sophie" last="Giraud">Sophie Giraud</name>
<affiliation wicri:level="1"><nlm:aff id="A4"> Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard, Lyon</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lasset, Christine" sort="Lasset, Christine" uniqKey="Lasset C" first="Christine" last="Lasset">Christine Lasset</name>
<affiliation wicri:level="1"><nlm:aff id="A15"> CNRS UMR5558, Université Lyon 1, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> CNRS UMR5558, Université Lyon 1, Lyon</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A16"> Unité de Prévention et d’Epidémiologie Génétique, Centre Léon Bérard, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Unité de Prévention et d’Epidémiologie Génétique, Centre Léon Bérard, Lyon</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Remenieras, Audrey" sort="Remenieras, Audrey" uniqKey="Remenieras A" first="Audrey" last="Remenieras">Audrey Remenieras</name>
<affiliation wicri:level="1"><nlm:aff id="A17"> Genetics Department, Institut de Cancérologie Gustave Roussy, Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Genetics Department, Institut de Cancérologie Gustave Roussy, Villejuif</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Caron, Olivier" sort="Caron, Olivier" uniqKey="Caron O" first="Olivier" last="Caron">Olivier Caron</name>
<affiliation wicri:level="1"><nlm:aff id="A18"> Consultation de Génétique, Département de Médecine, Institut de Cancérologie Gustave Roussy, Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Consultation de Génétique, Département de Médecine, Institut de Cancérologie Gustave Roussy, Villejuif</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hardouin, Agnes" sort="Hardouin, Agnes" uniqKey="Hardouin A" first="Agnès" last="Hardouin">Agnès Hardouin</name>
<affiliation wicri:level="1"><nlm:aff id="A19"> Centre François Baclesse, Caen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Centre François Baclesse, Caen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Berthet, Pascaline" sort="Berthet, Pascaline" uniqKey="Berthet P" first="Pascaline" last="Berthet">Pascaline Berthet</name>
<affiliation wicri:level="1"><nlm:aff id="A19"> Centre François Baclesse, Caen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Centre François Baclesse, Caen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hogervorst, Frans B L" sort="Hogervorst, Frans B L" uniqKey="Hogervorst F" first="Frans B L" last="Hogervorst">Frans B L. Hogervorst</name>
<affiliation wicri:level="1"><nlm:aff id="A21"> Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rookus, Matti A" sort="Rookus, Matti A" uniqKey="Rookus M" first="Matti A" last="Rookus">Matti A. Rookus</name>
<affiliation wicri:level="1"><nlm:aff id="A22"> Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Department of Epidemiology, Netherlands Cancer Institute, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jager, Agnes" sort="Jager, Agnes" uniqKey="Jager A" first="Agnes" last="Jager">Agnes Jager</name>
<affiliation wicri:level="1"><nlm:aff id="A23"> Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus University Medical Center, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Den Ouweland, Ans" sort="Van Den Ouweland, Ans" uniqKey="Van Den Ouweland A" first="Ans" last="Van Den Ouweland">Ans Van Den Ouweland</name>
<affiliation wicri:level="1"><nlm:aff id="A24"> Department of Clinical Genetics, Rotterdam Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Department of Clinical Genetics, Rotterdam Family Cancer Clinic, Erasmus University Medical Center, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hoogerbrugge, Nicoline" sort="Hoogerbrugge, Nicoline" uniqKey="Hoogerbrugge N" first="Nicoline" last="Hoogerbrugge">Nicoline Hoogerbrugge</name>
<affiliation wicri:level="1"><nlm:aff id="A25"> Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Der Luijt, Rob B" sort="Van Der Luijt, Rob B" uniqKey="Van Der Luijt R" first="Rob B" last="Van Der Luijt">Rob B. Van Der Luijt</name>
<affiliation wicri:level="1"><nlm:aff id="A26"> Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Department of Medical Genetics, University Medical Center Utrecht, Utrecht</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Meijers Heijboer, Hanne" sort="Meijers Heijboer, Hanne" uniqKey="Meijers Heijboer H" first="Hanne" last="Meijers-Heijboer">Hanne Meijers-Heijboer</name>
<affiliation wicri:level="1"><nlm:aff id="A27"> Department of Clinical Genetics, Vrije Universiteit (VU) Medical Center, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Department of Clinical Genetics, Vrije Universiteit (VU) Medical Center, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Garcia, Encarna B G Mez" sort="Garcia, Encarna B G Mez" uniqKey="Garcia E" first="Encarna B G Mez" last="García">Encarna B G Mez García</name>
<affiliation wicri:level="1"><nlm:aff id="A28"> Department of Clinical Genetics, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Department of Clinical Genetics, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name>
<affiliation wicri:level="1"><nlm:aff id="A30"> Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Department of Human Genetics, Leiden University Medical Center, Leiden</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A31"> Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Department of Pathology, Leiden University Medical Center, Leiden</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vreeswijk, Maaike P G" sort="Vreeswijk, Maaike P G" uniqKey="Vreeswijk M" first="Maaike P G" last="Vreeswijk">Maaike P G. Vreeswijk</name>
<affiliation wicri:level="1"><nlm:aff id="A32"> Department of Toxicogenetics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Department of Toxicogenetics, Leiden University Medical Center, Leiden</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name>
<affiliation wicri:level="1"><nlm:aff id="A33"> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name>
<affiliation wicri:level="1"><nlm:aff id="A33"> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gronwald, Jacek" sort="Gronwald, Jacek" uniqKey="Gronwald J" first="Jacek" last="Gronwald">Jacek Gronwald</name>
<affiliation wicri:level="1"><nlm:aff id="A33"> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Huzarski, Tomasz" sort="Huzarski, Tomasz" uniqKey="Huzarski T" first="Tomasz" last="Huzarski">Tomasz Huzarski</name>
<affiliation wicri:level="1"><nlm:aff id="A33"> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Byrski, Tomasz" sort="Byrski, Tomasz" uniqKey="Byrski T" first="Tomasz" last="Byrski">Tomasz Byrski</name>
<affiliation wicri:level="1"><nlm:aff id="A33"> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="G Rski, Bohdan" sort="G Rski, Bohdan" uniqKey="G Rski B" first="Bohdan" last="G Rski">Bohdan G Rski</name>
<affiliation wicri:level="1"><nlm:aff id="A33"> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cybulski, Cezary" sort="Cybulski, Cezary" uniqKey="Cybulski C" first="Cezary" last="Cybulski">Cezary Cybulski</name>
<affiliation wicri:level="1"><nlm:aff id="A33"> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B" last="Spurdle">Amanda B. Spurdle</name>
<affiliation wicri:level="1"><nlm:aff id="A6"> Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> Queensland Institute of Medical Research, Brisbane</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Holland, Helene" sort="Holland, Helene" uniqKey="Holland H" first="Helene" last="Holland">Helene Holland</name>
<affiliation wicri:level="1"><nlm:aff id="A6"> Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> Queensland Institute of Medical Research, Brisbane</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E" last="Goldgar">David E. Goldgar</name>
<affiliation wicri:level="1"><nlm:aff id="A35"> Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M" last="John">Esther M. John</name>
<affiliation wicri:level="1"><nlm:aff id="A36"> Cancer Prevention Institute of California, Stanford University School of Medicine, Stanford, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Cancer Prevention Institute of California, Stanford University School of Medicine, Stanford, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name>
<affiliation wicri:level="1"><nlm:aff id="A37"> The University of Melbourne, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> The University of Melbourne, Melbourne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Southey, Melissa" sort="Southey, Melissa" uniqKey="Southey M" first="Melissa" last="Southey">Melissa Southey</name>
<affiliation wicri:level="1"><nlm:aff id="A37"> The University of Melbourne, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> The University of Melbourne, Melbourne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Buys, Saundra S" sort="Buys, Saundra S" uniqKey="Buys S" first="Saundra S" last="Buys">Saundra S. Buys</name>
<affiliation wicri:level="1"><nlm:aff id="A38"> Huntsman Cancer Institute, University of Utah Health Sciences Centre, Salt Lake City, Utah, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Huntsman Cancer Institute, University of Utah Health Sciences Centre, Salt Lake City, Utah</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B" last="Daly">Mary B. Daly</name>
<affiliation wicri:level="1"><nlm:aff id="A39"> Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Fox Chase Cancer Center, Philadelphia, Pennsylvania</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Terry, Mary Beth" sort="Terry, Mary Beth" uniqKey="Terry M" first="Mary-Beth" last="Terry">Mary-Beth Terry</name>
<affiliation wicri:level="1"><nlm:aff id="A40"> Columbia University, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Columbia University, New York, New York</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K" last="Schmutzler">Rita K. Schmutzler</name>
<affiliation wicri:level="1"><nlm:aff id="A41"> Centre of Familial Breast and Ovarian Cancer, Department of Obstetrics and Gynaecology, University of Cologne, Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Centre of Familial Breast and Ovarian Cancer, Department of Obstetrics and Gynaecology, University of Cologne, Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A42"> Centre for Integrated Oncology (CIO), University of Cologne, Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Centre for Integrated Oncology (CIO), University of Cologne, Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wappenschmidt, Barbara" sort="Wappenschmidt, Barbara" uniqKey="Wappenschmidt B" first="Barbara" last="Wappenschmidt">Barbara Wappenschmidt</name>
<affiliation wicri:level="1"><nlm:aff id="A41"> Centre of Familial Breast and Ovarian Cancer, Department of Obstetrics and Gynaecology, University of Cologne, Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Centre of Familial Breast and Ovarian Cancer, Department of Obstetrics and Gynaecology, University of Cologne, Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A42"> Centre for Integrated Oncology (CIO), University of Cologne, Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Centre for Integrated Oncology (CIO), University of Cologne, Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Engel, Christoph" sort="Engel, Christoph" uniqKey="Engel C" first="Christoph" last="Engel">Christoph Engel</name>
<affiliation wicri:level="1"><nlm:aff id="A43"> Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name>
<affiliation wicri:level="1"><nlm:aff id="A44"> Department of Obstetrics and Gynaecology, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Department of Obstetrics and Gynaecology, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Munich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Preisler Adams, Sabine" sort="Preisler Adams, Sabine" uniqKey="Preisler Adams S" first="Sabine" last="Preisler-Adams">Sabine Preisler-Adams</name>
<affiliation wicri:level="1"><nlm:aff id="A45"> Institute of Human Genetics, University of Muenster, Muenster, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Institute of Human Genetics, University of Muenster, Muenster</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Arnold, Norbert" sort="Arnold, Norbert" uniqKey="Arnold N" first="Norbert" last="Arnold">Norbert Arnold</name>
<affiliation wicri:level="1"><nlm:aff id="A46"> Department of Obstetrics and Gynaecology, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University, Kiel, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Department of Obstetrics and Gynaecology, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University, Kiel</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Niederacher, Dieter" sort="Niederacher, Dieter" uniqKey="Niederacher D" first="Dieter" last="Niederacher">Dieter Niederacher</name>
<affiliation wicri:level="1"><nlm:aff id="A47"> Department of Obstetrics and Gynaecology, Division of Molecular Genetics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Dusseldorf, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Department of Obstetrics and Gynaecology, Division of Molecular Genetics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Dusseldorf</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sutter, Christian" sort="Sutter, Christian" uniqKey="Sutter C" first="Christian" last="Sutter">Christian Sutter</name>
<affiliation wicri:level="1"><nlm:aff id="A48"> Institute of Human Genetics, Division of Molecular Diagnostics, University Heidelberg, Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Institute of Human Genetics, Division of Molecular Diagnostics, University Heidelberg, Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M" last="Domchek">Susan M. Domchek</name>
<affiliation wicri:level="1"><nlm:aff id="A49"> University of Pennsylvania, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L" last="Nathanson">Katherine L. Nathanson</name>
<affiliation wicri:level="1"><nlm:aff id="A49"> University of Pennsylvania, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rebbeck, Timothy" sort="Rebbeck, Timothy" uniqKey="Rebbeck T" first="Timothy" last="Rebbeck">Timothy Rebbeck</name>
<affiliation wicri:level="1"><nlm:aff id="A49"> University of Pennsylvania, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Blum, Joanne L" sort="Blum, Joanne L" uniqKey="Blum J" first="Joanne L" last="Blum">Joanne L. Blum</name>
<affiliation wicri:level="1"><nlm:aff id="A50"> Baylor-Charles A. Sammons Cancer Center, Dallas, Texas, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Baylor-Charles A. Sammons Cancer Center, Dallas, Texas</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Piedmonte, Marion" sort="Piedmonte, Marion" uniqKey="Piedmonte M" first="Marion" last="Piedmonte">Marion Piedmonte</name>
<affiliation wicri:level="1"><nlm:aff id="A51"> Gynecology Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Gynecology Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, New York</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rodriguez, Gustavo C" sort="Rodriguez, Gustavo C" uniqKey="Rodriguez G" first="Gustavo C" last="Rodriguez">Gustavo C. Rodriguez</name>
<affiliation wicri:level="1"><nlm:aff id="A52"> Northshore University Health System, Evanston Northwestern Healthcare, Evanston, Illinois, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Northshore University Health System, Evanston Northwestern Healthcare, Evanston, Illinois</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wakeley, Katie" sort="Wakeley, Katie" uniqKey="Wakeley K" first="Katie" last="Wakeley">Katie Wakeley</name>
<affiliation wicri:level="1"><nlm:aff id="A53"> Tufts University, New England Medical Center, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Tufts University, New England Medical Center, Boston, Massachusetts</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Boggess, John F" sort="Boggess, John F" uniqKey="Boggess J" first="John F" last="Boggess">John F. Boggess</name>
<affiliation wicri:level="1"><nlm:aff id="A54"> University of North Carolina, Chapel Hill, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> University of North Carolina, Chapel Hill, North Carolina</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Basil, Jack" sort="Basil, Jack" uniqKey="Basil J" first="Jack" last="Basil">Jack Basil</name>
<affiliation wicri:level="1"><nlm:aff id="A55"> St. Elizabeth Medical Center, Edgewood, Kentucky, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> St. Elizabeth Medical Center, Edgewood, Kentucky</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Blank, Stephanie V" sort="Blank, Stephanie V" uniqKey="Blank S" first="Stephanie V" last="Blank">Stephanie V. Blank</name>
<affiliation wicri:level="1"><nlm:aff id="A56"> New York University School of Medicine, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> New York University School of Medicine, New York, New York</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name>
<affiliation wicri:level="1"><nlm:aff id="A57"> The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea> The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kaufman, Bella" sort="Kaufman, Bella" uniqKey="Kaufman B" first="Bella" last="Kaufman">Bella Kaufman</name>
<affiliation wicri:level="1"><nlm:aff id="A58"> Oncology Institute, Sheba Medical Center, Tel-Hashomer, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea> Oncology Institute, Sheba Medical Center, Tel-Hashomer</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Laitman, Yael" sort="Laitman, Yael" uniqKey="Laitman Y" first="Yael" last="Laitman">Yael Laitman</name>
<affiliation wicri:level="1"><nlm:aff id="A57"> The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea> The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Milgrom, Roni" sort="Milgrom, Roni" uniqKey="Milgrom R" first="Roni" last="Milgrom">Roni Milgrom</name>
<affiliation wicri:level="1"><nlm:aff id="A57"> The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea> The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L" last="Andrulis">Irene L. Andrulis</name>
<affiliation wicri:level="1"><nlm:aff id="A59"> Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea> Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A60"> Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea> Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A61"> Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea> Department of Molecular Genetics, University of Toronto, Toronto, Ontario</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name>
<affiliation wicri:level="1"><nlm:aff id="A59"> Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea> Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ozcelik, Hilmi" sort="Ozcelik, Hilmi" uniqKey="Ozcelik H" first="Hilmi" last="Ozcelik">Hilmi Ozcelik</name>
<affiliation wicri:level="1"><nlm:aff id="A60"> Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea> Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kirchhoff, Tomas" sort="Kirchhoff, Tomas" uniqKey="Kirchhoff T" first="Tomas" last="Kirchhoff">Tomas Kirchhoff</name>
<affiliation wicri:level="1"><nlm:aff id="A62"> Clinical Genetics Service, Memorial Hospital, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Clinical Genetics Service, Memorial Hospital, New York, New York</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A63"> Cancer Biology and Genetics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Cancer Biology and Genetics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vijai, Joseph" sort="Vijai, Joseph" uniqKey="Vijai J" first="Joseph" last="Vijai">Joseph Vijai</name>
<affiliation wicri:level="1"><nlm:aff id="A62"> Clinical Genetics Service, Memorial Hospital, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Clinical Genetics Service, Memorial Hospital, New York, New York</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A63"> Cancer Biology and Genetics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Cancer Biology and Genetics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M" last="Gaudet">Mia M. Gaudet</name>
<affiliation wicri:level="1"><nlm:aff id="A64"> Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, New York</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A65"> Department of Obstetrics and Gynecology and Women’s Health, Albert Einstein College of Medicine, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Obstetrics and Gynecology and Women’s Health, Albert Einstein College of Medicine, New York, New York</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Altshuler, David" sort="Altshuler, David" uniqKey="Altshuler D" first="David" last="Altshuler">David Altshuler</name>
<affiliation wicri:level="1"><nlm:aff id="A66"> Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Guiducci, Candace" sort="Guiducci, Candace" uniqKey="Guiducci C" first="Candace" last="Guiducci">Candace Guiducci</name>
<affiliation wicri:level="1"><nlm:aff id="A66"> Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Loman, Niklas" sort="Loman, Niklas" uniqKey="Loman N" first="Niklas" last="Loman">Niklas Loman</name>
<affiliation wicri:level="1"><nlm:aff id="A68"> Department of Oncology, Lund University, Lund, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea> Department of Oncology, Lund University, Lund</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Harbst, Katja" sort="Harbst, Katja" uniqKey="Harbst K" first="Katja" last="Harbst">Katja Harbst</name>
<affiliation wicri:level="1"><nlm:aff id="A68"> Department of Oncology, Lund University, Lund, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea> Department of Oncology, Lund University, Lund</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rantala, Johanna" sort="Rantala, Johanna" uniqKey="Rantala J" first="Johanna" last="Rantala">Johanna Rantala</name>
<affiliation wicri:level="1"><nlm:aff id="A69"> Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea> Department of Clinical Genetics, Karolinska University Hospital, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ehrencrona, Hans" sort="Ehrencrona, Hans" uniqKey="Ehrencrona H" first="Hans" last="Ehrencrona">Hans Ehrencrona</name>
<affiliation wicri:level="1"><nlm:aff id="A70"> Department of Genetics and Pathology Rudbeck Laboratory, Uppsala University, Uppsala, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea> Department of Genetics and Pathology Rudbeck Laboratory, Uppsala University, Uppsala</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gerdes, Anne Marie" sort="Gerdes, Anne Marie" uniqKey="Gerdes A" first="Anne-Marie" last="Gerdes">Anne-Marie Gerdes</name>
<affiliation wicri:level="1"><nlm:aff id="A71"> Department of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea> Department of Clinical Genetics, Rigshospitalet, Copenhagen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name>
<affiliation wicri:level="1"><nlm:aff id="A72"> Department of Clinical Genetics, Odense University Hospital, Odense, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea> Department of Clinical Genetics, Odense University Hospital, Odense</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sunde, Lone" sort="Sunde, Lone" uniqKey="Sunde L" first="Lone" last="Sunde">Lone Sunde</name>
<affiliation wicri:level="1"><nlm:aff id="A73"> Department of Clinical Genetics, Aalborg and Aarhus University Hospital, Aaarhus, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea> Department of Clinical Genetics, Aalborg and Aarhus University Hospital, Aaarhus</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name>
<affiliation wicri:level="1"><nlm:aff id="A74"> Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale Tumori (INT), Milan</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A75"> IFOM, Fondazione Istituto Fondazione Italiana per la Ricera sul Cancro (FIRC) di Oncologia Molecolare, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> IFOM, Fondazione Istituto Fondazione Italiana per la Ricera sul Cancro (FIRC) di Oncologia Molecolare, Milan</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name>
<affiliation wicri:level="1"><nlm:aff id="A76"> Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name>
<affiliation wicri:level="1"><nlm:aff id="A77"> Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Viel, Alessandra" sort="Viel, Alessandra" uniqKey="Viel A" first="Alessandra" last="Viel">Alessandra Viel</name>
<affiliation wicri:level="1"><nlm:aff id="A78"> Division of Experimental Oncology, Centro di Riferimento Oncologico (CRO), IRCCS, Aviano (PN), Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> Division of Experimental Oncology, Centro di Riferimento Oncologico (CRO), IRCCS, Aviano (PN)</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name>
<affiliation wicri:level="1"><nlm:aff id="A74"> Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale Tumori (INT), Milan</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A75"> IFOM, Fondazione Istituto Fondazione Italiana per la Ricera sul Cancro (FIRC) di Oncologia Molecolare, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> IFOM, Fondazione Istituto Fondazione Italiana per la Ricera sul Cancro (FIRC) di Oncologia Molecolare, Milan</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Caldes, Trinidad" sort="Caldes, Trinidad" uniqKey="Caldes T" first="Trinidad" last="Caldes">Trinidad Caldes</name>
<affiliation wicri:level="1"><nlm:aff id="A79"> Hospital Clinico San Carlos, Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea> Hospital Clinico San Carlos, Madrid</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De La Hoya, Miguel" sort="De La Hoya, Miguel" uniqKey="De La Hoya M" first="Miguel" last="De La Hoya">Miguel De La Hoya</name>
<affiliation wicri:level="1"><nlm:aff id="A77"> Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Singer, Christian F" sort="Singer, Christian F" uniqKey="Singer C" first="Christian F" last="Singer">Christian F. Singer</name>
<affiliation wicri:level="1"><nlm:aff id="A80"> Department of Obstetrics/Gynocology, Medical University of Vienna, Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea> Department of Obstetrics/Gynocology, Medical University of Vienna, Vienna</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fink Retter, Anneliese" sort="Fink Retter, Anneliese" uniqKey="Fink Retter A" first="Anneliese" last="Fink-Retter">Anneliese Fink-Retter</name>
<affiliation wicri:level="1"><nlm:aff id="A80"> Department of Obstetrics/Gynocology, Medical University of Vienna, Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea> Department of Obstetrics/Gynocology, Medical University of Vienna, Vienna</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H" last="Greene">Mark H. Greene</name>
<affiliation wicri:level="1"><nlm:aff id="A81"> Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L" last="Mai">Phuong L. Mai</name>
<affiliation wicri:level="1"><nlm:aff id="A81"> Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Loud, Jennifer T" sort="Loud, Jennifer T" uniqKey="Loud J" first="Jennifer T" last="Loud">Jennifer T. Loud</name>
<affiliation wicri:level="1"><nlm:aff id="A81"> Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Guidugli, Lucia" sort="Guidugli, Lucia" uniqKey="Guidugli L" first="Lucia" last="Guidugli">Lucia Guidugli</name>
<affiliation wicri:level="1"><nlm:aff id="A2"> Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lindor, Noralane M" sort="Lindor, Noralane M" uniqKey="Lindor N" first="Noralane M" last="Lindor">Noralane M. Lindor</name>
<affiliation wicri:level="1"><nlm:aff id="A82"> Medical Genetics, Mayo Clinic Rochester, Rochester, Minnesota, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Medical Genetics, Mayo Clinic Rochester, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hansen, Thomas V O" sort="Hansen, Thomas V O" uniqKey="Hansen T" first="Thomas V O" last="Hansen">Thomas V O. Hansen</name>
<affiliation wicri:level="1"><nlm:aff id="A83"> Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea> Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nielsen, Finn C" sort="Nielsen, Finn C" uniqKey="Nielsen F" first="Finn C" last="Nielsen">Finn C. Nielsen</name>
<affiliation wicri:level="1"><nlm:aff id="A83"> Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea> Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Blanco, Ignacio" sort="Blanco, Ignacio" uniqKey="Blanco I" first="Ignacio" last="Blanco">Ignacio Blanco</name>
<affiliation wicri:level="1"><nlm:aff id="A84"> Hereditary Cancer Program, Catalan Institute of Oncology, Gran Via de l’Hospitalet, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea> Hereditary Cancer Program, Catalan Institute of Oncology, Gran Via de l’Hospitalet, Barcelona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lazaro, Conxi" sort="Lazaro, Conxi" uniqKey="Lazaro C" first="Conxi" last="Lazaro">Conxi Lazaro</name>
<affiliation wicri:level="1"><nlm:aff id="A84"> Hereditary Cancer Program, Catalan Institute of Oncology, Gran Via de l’Hospitalet, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea> Hereditary Cancer Program, Catalan Institute of Oncology, Gran Via de l’Hospitalet, Barcelona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Garber, Judy" sort="Garber, Judy" uniqKey="Garber J" first="Judy" last="Garber">Judy Garber</name>
<affiliation wicri:level="1"><nlm:aff id="A85"> Dana-Farber Cancer Institute, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Dana-Farber Cancer Institute, Boston, Massachusetts</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ramus, Susan J" sort="Ramus, Susan J" uniqKey="Ramus S" first="Susan J" last="Ramus">Susan J. Ramus</name>
<affiliation wicri:level="1"><nlm:aff id="A86"> Department of Gynaecological Oncology, University College London, Elizabeth Garrett Anderson (EGA) Institute for Women’s Health, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Department of Gynaecological Oncology, University College London, Elizabeth Garrett Anderson (EGA) Institute for Women’s Health, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gayther, Simon A" sort="Gayther, Simon A" uniqKey="Gayther S" first="Simon A" last="Gayther">Simon A. Gayther</name>
<affiliation wicri:level="1"><nlm:aff id="A86"> Department of Gynaecological Oncology, University College London, Elizabeth Garrett Anderson (EGA) Institute for Women’s Health, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Department of Gynaecological Oncology, University College London, Elizabeth Garrett Anderson (EGA) Institute for Women’s Health, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Phelan, Catherine" sort="Phelan, Catherine" uniqKey="Phelan C" first="Catherine" last="Phelan">Catherine Phelan</name>
<affiliation wicri:level="1"><nlm:aff id="A87"> Women’s College Research Institute, Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea> Women’s College Research Institute, Toronto, Ontario</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Narod, Stephen" sort="Narod, Stephen" uniqKey="Narod S" first="Stephen" last="Narod">Stephen Narod</name>
<affiliation wicri:level="1"><nlm:aff id="A88"> Department of Epidemiology and Genetics, H. Lee Moffitt Cancer Center, Tampa, Florida, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Epidemiology and Genetics, H. Lee Moffitt Cancer Center, Tampa, Florida</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Szabo, Csilla I" sort="Szabo, Csilla I" uniqKey="Szabo C" first="Csilla I" last="Szabo">Csilla I. Szabo</name>
<affiliation wicri:level="1"><nlm:aff id="A2"> Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name>
<affiliation wicri:level="1"><nlm:aff id="A90"> Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea> Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name>
<affiliation wicri:level="1"><nlm:aff id="A90"> Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea> Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name>
<affiliation wicri:level="1"><nlm:aff id="A91"> Helsinki University Central Hospital, Department of Obstetrics and Gynecology, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea> Helsinki University Central Hospital, Department of Obstetrics and Gynecology, Helsinki</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Heikkinen, Tuomas" sort="Heikkinen, Tuomas" uniqKey="Heikkinen T" first="Tuomas" last="Heikkinen">Tuomas Heikkinen</name>
<affiliation wicri:level="1"><nlm:aff id="A91"> Helsinki University Central Hospital, Department of Obstetrics and Gynecology, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea> Helsinki University Central Hospital, Department of Obstetrics and Gynecology, Helsinki</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Caligo, Maria A" sort="Caligo, Maria A" uniqKey="Caligo M" first="Maria A" last="Caligo">Maria A. Caligo</name>
<affiliation wicri:level="1"><nlm:aff id="A92"> Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, Pisa University Hospital, Pisa, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, Pisa University Hospital, Pisa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Beattie, Mary S" sort="Beattie, Mary S" uniqKey="Beattie M" first="Mary S" last="Beattie">Mary S. Beattie</name>
<affiliation wicri:level="1"><nlm:aff id="A93"> Department of Medicine, University of California, San Francisco, San Francisco, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Medicine, University of California, San Francisco, San Francisco, California</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A94"> Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A95"> Cancer Risk Program, Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Cancer Risk Program, Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name>
<affiliation wicri:level="1"><nlm:aff id="A96"> German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K" last="Godwin">Andrew K. Godwin</name>
<affiliation wicri:level="1"><nlm:aff id="A39"> Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Fox Chase Cancer Center, Philadelphia, Pennsylvania</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name>
<affiliation wicri:level="1"><nlm:aff id="A97"> Istituto Oncologico Veneto-IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> Istituto Oncologico Veneto-IRCCS, Immunology and Molecular Oncology Unit, Padua</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Casella, Cinzia" sort="Casella, Cinzia" uniqKey="Casella C" first="Cinzia" last="Casella">Cinzia Casella</name>
<affiliation wicri:level="1"><nlm:aff id="A97"> Istituto Oncologico Veneto-IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> Istituto Oncologico Veneto-IRCCS, Immunology and Molecular Oncology Unit, Padua</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L" last="Neuhausen">Susan L. Neuhausen</name>
<affiliation wicri:level="1"><nlm:aff id="A98"> Department of Population Sciences, The Beckman Research Institute of the City of Hope, Duarte, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Population Sciences, The Beckman Research Institute of the City of Hope, Duarte, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Karlan, Beth Y" sort="Karlan, Beth Y" uniqKey="Karlan B" first="Beth Y" last="Karlan">Beth Y. Karlan</name>
<affiliation wicri:level="1"><nlm:aff id="A99"> Women’s Cancer Research Institute at the Samuel Oschin Cancer Institute, Division of Gynecologic Oncology, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Women’s Cancer Research Institute at the Samuel Oschin Cancer Institute, Division of Gynecologic Oncology, Cedars-Sinai Medical Center, Los Angeles, California</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A100"> Department of Obstetrics and Gynecology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Obstetrics and Gynecology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tung, Nadine" sort="Tung, Nadine" uniqKey="Tung N" first="Nadine" last="Tung">Nadine Tung</name>
<affiliation wicri:level="1"><nlm:aff id="A101"> Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Beth Israel Deaconess Medical Center, Boston, Massachusetts</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E" last="Toland">Amanda E. Toland</name>
<affiliation wicri:level="1"><nlm:aff id="A102"> Comprehensive Cancer Center, Department of Molecular Virology, Immunology and Medical Genetics, Division of Human Genetics, Department of Internal Medicine, Ohio State University, Columbus, Ohio, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Comprehensive Cancer Center, Department of Molecular Virology, Immunology and Medical Genetics, Division of Human Genetics, Department of Internal Medicine, Ohio State University, Columbus, Ohio</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Weitzel, Jeffrey" sort="Weitzel, Jeffrey" uniqKey="Weitzel J" first="Jeffrey" last="Weitzel">Jeffrey Weitzel</name>
<affiliation wicri:level="1"><nlm:aff id="A103"> Division of Clinical Cancer Genetics, City of Hope Cancer Center, Duarte, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Division of Clinical Cancer Genetics, City of Hope Cancer Center, Duarte, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Olopade, Olofunmilayo" sort="Olopade, Olofunmilayo" uniqKey="Olopade O" first="Olofunmilayo" last="Olopade">Olofunmilayo Olopade</name>
<affiliation wicri:level="1"><nlm:aff id="A104"> University of Chicago Medical Center, Chicago, Illinois, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> University of Chicago Medical Center, Chicago, Illinois</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name>
<affiliation wicri:level="1"><nlm:aff id="A105"> Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Quebec, Québec City, Quebec, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea> Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Quebec, Québec City, Quebec</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A106"> Université Laval, Centre de recherche du Centre Hospitalier Universitaire de Quebéc (CHUQ), Québec City, Quebec, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea> Université Laval, Centre de recherche du Centre Hospitalier Universitaire de Quebéc (CHUQ), Québec City, Quebec</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name>
<affiliation wicri:level="1"><nlm:aff id="A105"> Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Quebec, Québec City, Quebec, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea> Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Quebec, Québec City, Quebec</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rubinstein, Wendy S" sort="Rubinstein, Wendy S" uniqKey="Rubinstein W" first="Wendy S" last="Rubinstein">Wendy S. Rubinstein</name>
<affiliation wicri:level="1"><nlm:aff id="A107"> Northshore University Health System, Evanston, Illinois, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Northshore University Health System, Evanston, Illinois</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Arason, Adalgeir" sort="Arason, Adalgeir" uniqKey="Arason A" first="Adalgeir" last="Arason">Adalgeir Arason</name>
<affiliation wicri:level="1"><nlm:aff id="A108"> Department of Pathology, Landspitali University Hospital, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea> Department of Pathology, Landspitali University Hospital, Reykjavik</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name>
<affiliation wicri:level="1"><nlm:aff id="A109"> QIMR GWAS Collective, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> QIMR GWAS Collective, Queensland Institute of Medical Research, Brisbane</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name>
<affiliation wicri:level="1"><nlm:aff id="A110"> Clalit Health Services National Cancer Control Center, Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Technion, Haifa, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea> Clalit Health Services National Cancer Control Center, Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Technion, Haifa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W" last="Montgomery">Grant W. Montgomery</name>
<affiliation wicri:level="1"><nlm:aff id="A110"> Clalit Health Services National Cancer Control Center, Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Technion, Haifa, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea> Clalit Health Services National Cancer Control Center, Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Technion, Haifa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name>
<affiliation wicri:level="1"><nlm:aff id="A111"> Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name>
<affiliation wicri:level="1"><nlm:aff id="A112"> Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name>
<affiliation wicri:level="1"><nlm:aff id="A113"> Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A114"> University Tübingen, Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> University Tübingen, Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
<affiliation wicri:level="1"><nlm:aff id="A116"> Melbourne Collaborative Cohort Study (MCCS), Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> Melbourne Collaborative Cohort Study (MCCS), Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name>
<affiliation wicri:level="1"><nlm:aff id="A116"> Melbourne Collaborative Cohort Study (MCCS), Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> Melbourne Collaborative Cohort Study (MCCS), Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name>
<affiliation wicri:level="1"><nlm:aff id="A117"> Institute for Cancer Studies, Department of Oncology, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Institute for Cancer Studies, Department of Oncology, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S" last="Cross">Simon S. Cross</name>
<affiliation wicri:level="1"><nlm:aff id="A118"> Academic Unit of Pathology, Department of Neuroscience, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Academic Unit of Pathology, Department of Neuroscience, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Miron, Penelope" sort="Miron, Penelope" uniqKey="Miron P" first="Penelope" last="Miron">Penelope Miron</name>
<affiliation wicri:level="1"><nlm:aff id="A119"> Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gerty, Sue M" sort="Gerty, Sue M" uniqKey="Gerty S" first="Sue M" last="Gerty">Sue M. Gerty</name>
<affiliation wicri:level="1"><nlm:aff id="A7"> Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tapper, William" sort="Tapper, William" uniqKey="Tapper W" first="William" last="Tapper">William Tapper</name>
<affiliation wicri:level="1"><nlm:aff id="A7"> Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name>
<affiliation wicri:level="1"><nlm:aff id="A120"> Molecular Diagnostics Laboratory Institute of Radioisotopes and Radiodiagnostic Products, National Centre for Scientific Research ‘Demokritos’, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea> Molecular Diagnostics Laboratory Institute of Radioisotopes and Radiodiagnostic Products, National Centre for Scientific Research ‘Demokritos’, Athens</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fountzilas, George" sort="Fountzilas, George" uniqKey="Fountzilas G" first="George" last="Fountzilas">George Fountzilas</name>
<affiliation wicri:level="1"><nlm:aff id="A121"> Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea> Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A122"> Hellenic Cooperative Oncology Group, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea> Hellenic Cooperative Oncology Group</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A" last="Fasching">Peter A. Fasching</name>
<affiliation wicri:level="1"><nlm:aff id="A123"> University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, Los Angeles, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W" last="Beckmann">Matthias W. Beckmann</name>
<affiliation wicri:level="1"><nlm:aff id="A124"> University Hospital Erlangen, Department of Gynecology and Obstetrics, Erlangen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> University Hospital Erlangen, Department of Gynecology and Obstetrics, Erlangen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Silva, Isabel Dos Santos" sort="Silva, Isabel Dos Santos" uniqKey="Silva I" first="Isabel Dos Santos" last="Silva">Isabel Dos Santos Silva</name>
<affiliation wicri:level="1"><nlm:aff id="A125"> Cancer Research UK Epidemiology and Genetics Group, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Cancer Research UK Epidemiology and Genetics Group, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name>
<affiliation wicri:level="1"><nlm:aff id="A125"> Cancer Research UK Epidemiology and Genetics Group, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Cancer Research UK Epidemiology and Genetics Group, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name>
<affiliation wicri:level="1"><nlm:aff id="A126"> Vesalius Research Center (VRC), VIB, Leuven, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea> Vesalius Research Center (VRC), VIB, Leuven</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Paridaens, Robert" sort="Paridaens, Robert" uniqKey="Paridaens R" first="Robert" last="Paridaens">Robert Paridaens</name>
<affiliation wicri:level="1"><nlm:aff id="A127"> Multidisciplinary Breast Center, University Hospitals Leuven, Leuven, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea> Multidisciplinary Breast Center, University Hospitals Leuven, Leuven</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rudiger, Thomas" sort="Rudiger, Thomas" uniqKey="Rudiger T" first="Thomas" last="Rüdiger">Thomas Rüdiger</name>
<affiliation wicri:level="1"><nlm:aff id="A128"> Institute of Pathology, Städtisches Klinikum Karlsruhe, Karlsruhe, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Institute of Pathology, Städtisches Klinikum Karlsruhe, Karlsruhe</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Forsti, Asta" sort="Forsti, Asta" uniqKey="Forsti A" first="Asta" last="Försti">Asta Försti</name>
<affiliation wicri:level="1"><nlm:aff id="A96"> German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A129"> Center for Primary Health Care Research, University of Lund, Lund, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea> Center for Primary Health Care Research, University of Lund, Lund</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name>
<affiliation wicri:level="1"><nlm:aff id="A130"> Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea> Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name>
<affiliation wicri:level="1"><nlm:aff id="A130"> Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea> Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Diasio, Robert B" sort="Diasio, Robert B" uniqKey="Diasio R" first="Robert B" last="Diasio">Robert B. Diasio</name>
<affiliation wicri:level="1"><nlm:aff id="A131"> Department of Pharmacology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Pharmacology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lee, Adam M" sort="Lee, Adam M" uniqKey="Lee A" first="Adam M" last="Lee">Adam M. Lee</name>
<affiliation wicri:level="1"><nlm:aff id="A131"> Department of Pharmacology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Pharmacology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eckel Passow, Jeanette" sort="Eckel Passow, Jeanette" uniqKey="Eckel Passow J" first="Jeanette" last="Eckel-Passow">Jeanette Eckel-Passow</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Blows, Fiona" sort="Blows, Fiona" uniqKey="Blows F" first="Fiona" last="Blows">Fiona Blows</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Driver, Kristy" sort="Driver, Kristy" uniqKey="Driver K" first="Kristy" last="Driver">Kristy Driver</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dunning, Alison" sort="Dunning, Alison" uniqKey="Dunning A" first="Alison" last="Dunning">Alison Dunning</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pharoah, Paul P D" sort="Pharoah, Paul P D" uniqKey="Pharoah P" first="Paul P D" last="Pharoah">Paul P D. Pharoah</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name>
<affiliation wicri:level="1"><nlm:aff id="A61"> Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea> Department of Molecular Genetics, University of Toronto, Toronto, Ontario</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pankratz, V Shane" sort="Pankratz, V Shane" uniqKey="Pankratz V" first="V Shane" last="Pankratz">V Shane Pankratz</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name>
<affiliation wicri:level="1"><nlm:aff id="A132"> Center for Applied Genomics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Center for Applied Genomics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
<affiliation wicri:level="1"><nlm:aff id="A6"> Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> Queensland Institute of Medical Research, Brisbane</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F" last="Easton">Douglas F. Easton</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J" last="Couch">Fergus J. Couch</name>
<affiliation wicri:level="1"><nlm:aff id="A2"> Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A locus on 19p13 modifies risk of breast cancer in <italic>BRCA1</italic>
 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population</title>
<author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C" last="Antoniou">Antonis C. Antoniou</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name>
<affiliation wicri:level="1"><nlm:aff id="A2"> Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fredericksen, Zachary S" sort="Fredericksen, Zachary S" uniqKey="Fredericksen Z" first="Zachary S" last="Fredericksen">Zachary S. Fredericksen</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tarrell, Robert" sort="Tarrell, Robert" uniqKey="Tarrell R" first="Robert" last="Tarrell">Robert Tarrell</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M" last="Sinilnikova">Olga M. Sinilnikova</name>
<affiliation wicri:level="1"><nlm:aff id="A4"> Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard, Lyon</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A5"> Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name>
<affiliation wicri:level="1"><nlm:aff id="A6"> Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> Queensland Institute of Medical Research, Brisbane</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Morrison, Jonathan" sort="Morrison, Jonathan" uniqKey="Morrison J" first="Jonathan" last="Morrison">Jonathan Morrison</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kartsonaki, Christiana" sort="Kartsonaki, Christiana" uniqKey="Kartsonaki C" first="Christiana" last="Kartsonaki">Christiana Kartsonaki</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lesnick, Timothy" sort="Lesnick, Timothy" uniqKey="Lesnick T" first="Timothy" last="Lesnick">Timothy Lesnick</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ghoussaini, Maya" sort="Ghoussaini, Maya" uniqKey="Ghoussaini M" first="Maya" last="Ghoussaini">Maya Ghoussaini</name>
<affiliation wicri:level="1"><nlm:aff id="A6"> Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> Queensland Institute of Medical Research, Brisbane</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Barrowdale, Daniel" sort="Barrowdale, Daniel" uniqKey="Barrowdale D" first="Daniel" last="Barrowdale">Daniel Barrowdale</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peock, Susan" sort="Peock, Susan" uniqKey="Peock S" first="Susan" last="Peock">Susan Peock</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cook, Margaret" sort="Cook, Margaret" uniqKey="Cook M" first="Margaret" last="Cook">Margaret Cook</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Oliver, Clare" sort="Oliver, Clare" uniqKey="Oliver C" first="Clare" last="Oliver">Clare Oliver</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Frost, Debra" sort="Frost, Debra" uniqKey="Frost D" first="Debra" last="Frost">Debra Frost</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eccles, Diana" sort="Eccles, Diana" uniqKey="Eccles D" first="Diana" last="Eccles">Diana Eccles</name>
<affiliation wicri:level="1"><nlm:aff id="A7"> Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Evans, D Gareth" sort="Evans, D Gareth" uniqKey="Evans D" first="D Gareth" last="Evans">D Gareth Evans</name>
<affiliation wicri:level="1"><nlm:aff id="A8"> Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals National Health Service (NHSFT) Foundation Trust, Manchester, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals National Health Service (NHSFT) Foundation Trust, Manchester</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eeles, Ros" sort="Eeles, Ros" uniqKey="Eeles R" first="Ros" last="Eeles">Ros Eeles</name>
<affiliation wicri:level="1"><nlm:aff id="A9"> Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Izatt, Louise" sort="Izatt, Louise" uniqKey="Izatt L" first="Louise" last="Izatt">Louise Izatt</name>
<affiliation wicri:level="1"><nlm:aff id="A10"> Clinical Genetics, Guy’s and St. Thomas’ NHS Foundation Trust, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Clinical Genetics, Guy’s and St. Thomas’ NHS Foundation Trust, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chu, Carol" sort="Chu, Carol" uniqKey="Chu C" first="Carol" last="Chu">Carol Chu</name>
<affiliation wicri:level="1"><nlm:aff id="A11"> Yorkshire Regional Genetics Service, Leeds, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Yorkshire Regional Genetics Service, Leeds</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Douglas, Fiona" sort="Douglas, Fiona" uniqKey="Douglas F" first="Fiona" last="Douglas">Fiona Douglas</name>
<affiliation wicri:level="1"><nlm:aff id="A12"> Institute of Human Genetics, Centre for Life, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Institute of Human Genetics, Centre for Life, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle upon Tyne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Paterson, Joan" sort="Paterson, Joan" uniqKey="Paterson J" first="Joan" last="Paterson">Joan Paterson</name>
<affiliation wicri:level="1"><nlm:aff id="A13"> Department of Clinical Genetics, East Anglian Regional Genetics Service, Addenbrookes Hospital, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Department of Clinical Genetics, East Anglian Regional Genetics Service, Addenbrookes Hospital, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name>
<affiliation wicri:level="1"><nlm:aff id="A14"> INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes, Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Houdayer, Claude" sort="Houdayer, Claude" uniqKey="Houdayer C" first="Claude" last="Houdayer">Claude Houdayer</name>
<affiliation wicri:level="1"><nlm:aff id="A14"> INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes, Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name>
<affiliation wicri:level="1"><nlm:aff id="A5"> Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Giraud, Sophie" sort="Giraud, Sophie" uniqKey="Giraud S" first="Sophie" last="Giraud">Sophie Giraud</name>
<affiliation wicri:level="1"><nlm:aff id="A4"> Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard, Lyon</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lasset, Christine" sort="Lasset, Christine" uniqKey="Lasset C" first="Christine" last="Lasset">Christine Lasset</name>
<affiliation wicri:level="1"><nlm:aff id="A15"> CNRS UMR5558, Université Lyon 1, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> CNRS UMR5558, Université Lyon 1, Lyon</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A16"> Unité de Prévention et d’Epidémiologie Génétique, Centre Léon Bérard, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Unité de Prévention et d’Epidémiologie Génétique, Centre Léon Bérard, Lyon</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Remenieras, Audrey" sort="Remenieras, Audrey" uniqKey="Remenieras A" first="Audrey" last="Remenieras">Audrey Remenieras</name>
<affiliation wicri:level="1"><nlm:aff id="A17"> Genetics Department, Institut de Cancérologie Gustave Roussy, Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Genetics Department, Institut de Cancérologie Gustave Roussy, Villejuif</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Caron, Olivier" sort="Caron, Olivier" uniqKey="Caron O" first="Olivier" last="Caron">Olivier Caron</name>
<affiliation wicri:level="1"><nlm:aff id="A18"> Consultation de Génétique, Département de Médecine, Institut de Cancérologie Gustave Roussy, Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Consultation de Génétique, Département de Médecine, Institut de Cancérologie Gustave Roussy, Villejuif</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hardouin, Agnes" sort="Hardouin, Agnes" uniqKey="Hardouin A" first="Agnès" last="Hardouin">Agnès Hardouin</name>
<affiliation wicri:level="1"><nlm:aff id="A19"> Centre François Baclesse, Caen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Centre François Baclesse, Caen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Berthet, Pascaline" sort="Berthet, Pascaline" uniqKey="Berthet P" first="Pascaline" last="Berthet">Pascaline Berthet</name>
<affiliation wicri:level="1"><nlm:aff id="A19"> Centre François Baclesse, Caen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Centre François Baclesse, Caen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hogervorst, Frans B L" sort="Hogervorst, Frans B L" uniqKey="Hogervorst F" first="Frans B L" last="Hogervorst">Frans B L. Hogervorst</name>
<affiliation wicri:level="1"><nlm:aff id="A21"> Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rookus, Matti A" sort="Rookus, Matti A" uniqKey="Rookus M" first="Matti A" last="Rookus">Matti A. Rookus</name>
<affiliation wicri:level="1"><nlm:aff id="A22"> Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Department of Epidemiology, Netherlands Cancer Institute, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jager, Agnes" sort="Jager, Agnes" uniqKey="Jager A" first="Agnes" last="Jager">Agnes Jager</name>
<affiliation wicri:level="1"><nlm:aff id="A23"> Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus University Medical Center, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Den Ouweland, Ans" sort="Van Den Ouweland, Ans" uniqKey="Van Den Ouweland A" first="Ans" last="Van Den Ouweland">Ans Van Den Ouweland</name>
<affiliation wicri:level="1"><nlm:aff id="A24"> Department of Clinical Genetics, Rotterdam Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Department of Clinical Genetics, Rotterdam Family Cancer Clinic, Erasmus University Medical Center, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hoogerbrugge, Nicoline" sort="Hoogerbrugge, Nicoline" uniqKey="Hoogerbrugge N" first="Nicoline" last="Hoogerbrugge">Nicoline Hoogerbrugge</name>
<affiliation wicri:level="1"><nlm:aff id="A25"> Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Der Luijt, Rob B" sort="Van Der Luijt, Rob B" uniqKey="Van Der Luijt R" first="Rob B" last="Van Der Luijt">Rob B. Van Der Luijt</name>
<affiliation wicri:level="1"><nlm:aff id="A26"> Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Department of Medical Genetics, University Medical Center Utrecht, Utrecht</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Meijers Heijboer, Hanne" sort="Meijers Heijboer, Hanne" uniqKey="Meijers Heijboer H" first="Hanne" last="Meijers-Heijboer">Hanne Meijers-Heijboer</name>
<affiliation wicri:level="1"><nlm:aff id="A27"> Department of Clinical Genetics, Vrije Universiteit (VU) Medical Center, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Department of Clinical Genetics, Vrije Universiteit (VU) Medical Center, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Garcia, Encarna B G Mez" sort="Garcia, Encarna B G Mez" uniqKey="Garcia E" first="Encarna B G Mez" last="García">Encarna B G Mez García</name>
<affiliation wicri:level="1"><nlm:aff id="A28"> Department of Clinical Genetics, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Department of Clinical Genetics, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name>
<affiliation wicri:level="1"><nlm:aff id="A30"> Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Department of Human Genetics, Leiden University Medical Center, Leiden</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A31"> Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Department of Pathology, Leiden University Medical Center, Leiden</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vreeswijk, Maaike P G" sort="Vreeswijk, Maaike P G" uniqKey="Vreeswijk M" first="Maaike P G" last="Vreeswijk">Maaike P G. Vreeswijk</name>
<affiliation wicri:level="1"><nlm:aff id="A32"> Department of Toxicogenetics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea> Department of Toxicogenetics, Leiden University Medical Center, Leiden</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name>
<affiliation wicri:level="1"><nlm:aff id="A33"> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name>
<affiliation wicri:level="1"><nlm:aff id="A33"> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gronwald, Jacek" sort="Gronwald, Jacek" uniqKey="Gronwald J" first="Jacek" last="Gronwald">Jacek Gronwald</name>
<affiliation wicri:level="1"><nlm:aff id="A33"> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Huzarski, Tomasz" sort="Huzarski, Tomasz" uniqKey="Huzarski T" first="Tomasz" last="Huzarski">Tomasz Huzarski</name>
<affiliation wicri:level="1"><nlm:aff id="A33"> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Byrski, Tomasz" sort="Byrski, Tomasz" uniqKey="Byrski T" first="Tomasz" last="Byrski">Tomasz Byrski</name>
<affiliation wicri:level="1"><nlm:aff id="A33"> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="G Rski, Bohdan" sort="G Rski, Bohdan" uniqKey="G Rski B" first="Bohdan" last="G Rski">Bohdan G Rski</name>
<affiliation wicri:level="1"><nlm:aff id="A33"> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cybulski, Cezary" sort="Cybulski, Cezary" uniqKey="Cybulski C" first="Cezary" last="Cybulski">Cezary Cybulski</name>
<affiliation wicri:level="1"><nlm:aff id="A33"> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B" last="Spurdle">Amanda B. Spurdle</name>
<affiliation wicri:level="1"><nlm:aff id="A6"> Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> Queensland Institute of Medical Research, Brisbane</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Holland, Helene" sort="Holland, Helene" uniqKey="Holland H" first="Helene" last="Holland">Helene Holland</name>
<affiliation wicri:level="1"><nlm:aff id="A6"> Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> Queensland Institute of Medical Research, Brisbane</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E" last="Goldgar">David E. Goldgar</name>
<affiliation wicri:level="1"><nlm:aff id="A35"> Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M" last="John">Esther M. John</name>
<affiliation wicri:level="1"><nlm:aff id="A36"> Cancer Prevention Institute of California, Stanford University School of Medicine, Stanford, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Cancer Prevention Institute of California, Stanford University School of Medicine, Stanford, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name>
<affiliation wicri:level="1"><nlm:aff id="A37"> The University of Melbourne, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> The University of Melbourne, Melbourne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Southey, Melissa" sort="Southey, Melissa" uniqKey="Southey M" first="Melissa" last="Southey">Melissa Southey</name>
<affiliation wicri:level="1"><nlm:aff id="A37"> The University of Melbourne, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> The University of Melbourne, Melbourne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Buys, Saundra S" sort="Buys, Saundra S" uniqKey="Buys S" first="Saundra S" last="Buys">Saundra S. Buys</name>
<affiliation wicri:level="1"><nlm:aff id="A38"> Huntsman Cancer Institute, University of Utah Health Sciences Centre, Salt Lake City, Utah, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Huntsman Cancer Institute, University of Utah Health Sciences Centre, Salt Lake City, Utah</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B" last="Daly">Mary B. Daly</name>
<affiliation wicri:level="1"><nlm:aff id="A39"> Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Fox Chase Cancer Center, Philadelphia, Pennsylvania</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Terry, Mary Beth" sort="Terry, Mary Beth" uniqKey="Terry M" first="Mary-Beth" last="Terry">Mary-Beth Terry</name>
<affiliation wicri:level="1"><nlm:aff id="A40"> Columbia University, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Columbia University, New York, New York</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K" last="Schmutzler">Rita K. Schmutzler</name>
<affiliation wicri:level="1"><nlm:aff id="A41"> Centre of Familial Breast and Ovarian Cancer, Department of Obstetrics and Gynaecology, University of Cologne, Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Centre of Familial Breast and Ovarian Cancer, Department of Obstetrics and Gynaecology, University of Cologne, Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A42"> Centre for Integrated Oncology (CIO), University of Cologne, Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Centre for Integrated Oncology (CIO), University of Cologne, Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wappenschmidt, Barbara" sort="Wappenschmidt, Barbara" uniqKey="Wappenschmidt B" first="Barbara" last="Wappenschmidt">Barbara Wappenschmidt</name>
<affiliation wicri:level="1"><nlm:aff id="A41"> Centre of Familial Breast and Ovarian Cancer, Department of Obstetrics and Gynaecology, University of Cologne, Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Centre of Familial Breast and Ovarian Cancer, Department of Obstetrics and Gynaecology, University of Cologne, Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A42"> Centre for Integrated Oncology (CIO), University of Cologne, Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Centre for Integrated Oncology (CIO), University of Cologne, Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Engel, Christoph" sort="Engel, Christoph" uniqKey="Engel C" first="Christoph" last="Engel">Christoph Engel</name>
<affiliation wicri:level="1"><nlm:aff id="A43"> Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name>
<affiliation wicri:level="1"><nlm:aff id="A44"> Department of Obstetrics and Gynaecology, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Department of Obstetrics and Gynaecology, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Munich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Preisler Adams, Sabine" sort="Preisler Adams, Sabine" uniqKey="Preisler Adams S" first="Sabine" last="Preisler-Adams">Sabine Preisler-Adams</name>
<affiliation wicri:level="1"><nlm:aff id="A45"> Institute of Human Genetics, University of Muenster, Muenster, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Institute of Human Genetics, University of Muenster, Muenster</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Arnold, Norbert" sort="Arnold, Norbert" uniqKey="Arnold N" first="Norbert" last="Arnold">Norbert Arnold</name>
<affiliation wicri:level="1"><nlm:aff id="A46"> Department of Obstetrics and Gynaecology, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University, Kiel, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Department of Obstetrics and Gynaecology, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University, Kiel</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Niederacher, Dieter" sort="Niederacher, Dieter" uniqKey="Niederacher D" first="Dieter" last="Niederacher">Dieter Niederacher</name>
<affiliation wicri:level="1"><nlm:aff id="A47"> Department of Obstetrics and Gynaecology, Division of Molecular Genetics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Dusseldorf, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Department of Obstetrics and Gynaecology, Division of Molecular Genetics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Dusseldorf</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sutter, Christian" sort="Sutter, Christian" uniqKey="Sutter C" first="Christian" last="Sutter">Christian Sutter</name>
<affiliation wicri:level="1"><nlm:aff id="A48"> Institute of Human Genetics, Division of Molecular Diagnostics, University Heidelberg, Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Institute of Human Genetics, Division of Molecular Diagnostics, University Heidelberg, Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M" last="Domchek">Susan M. Domchek</name>
<affiliation wicri:level="1"><nlm:aff id="A49"> University of Pennsylvania, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L" last="Nathanson">Katherine L. Nathanson</name>
<affiliation wicri:level="1"><nlm:aff id="A49"> University of Pennsylvania, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rebbeck, Timothy" sort="Rebbeck, Timothy" uniqKey="Rebbeck T" first="Timothy" last="Rebbeck">Timothy Rebbeck</name>
<affiliation wicri:level="1"><nlm:aff id="A49"> University of Pennsylvania, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Blum, Joanne L" sort="Blum, Joanne L" uniqKey="Blum J" first="Joanne L" last="Blum">Joanne L. Blum</name>
<affiliation wicri:level="1"><nlm:aff id="A50"> Baylor-Charles A. Sammons Cancer Center, Dallas, Texas, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Baylor-Charles A. Sammons Cancer Center, Dallas, Texas</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Piedmonte, Marion" sort="Piedmonte, Marion" uniqKey="Piedmonte M" first="Marion" last="Piedmonte">Marion Piedmonte</name>
<affiliation wicri:level="1"><nlm:aff id="A51"> Gynecology Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Gynecology Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, New York</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rodriguez, Gustavo C" sort="Rodriguez, Gustavo C" uniqKey="Rodriguez G" first="Gustavo C" last="Rodriguez">Gustavo C. Rodriguez</name>
<affiliation wicri:level="1"><nlm:aff id="A52"> Northshore University Health System, Evanston Northwestern Healthcare, Evanston, Illinois, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Northshore University Health System, Evanston Northwestern Healthcare, Evanston, Illinois</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wakeley, Katie" sort="Wakeley, Katie" uniqKey="Wakeley K" first="Katie" last="Wakeley">Katie Wakeley</name>
<affiliation wicri:level="1"><nlm:aff id="A53"> Tufts University, New England Medical Center, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Tufts University, New England Medical Center, Boston, Massachusetts</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Boggess, John F" sort="Boggess, John F" uniqKey="Boggess J" first="John F" last="Boggess">John F. Boggess</name>
<affiliation wicri:level="1"><nlm:aff id="A54"> University of North Carolina, Chapel Hill, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> University of North Carolina, Chapel Hill, North Carolina</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Basil, Jack" sort="Basil, Jack" uniqKey="Basil J" first="Jack" last="Basil">Jack Basil</name>
<affiliation wicri:level="1"><nlm:aff id="A55"> St. Elizabeth Medical Center, Edgewood, Kentucky, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> St. Elizabeth Medical Center, Edgewood, Kentucky</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Blank, Stephanie V" sort="Blank, Stephanie V" uniqKey="Blank S" first="Stephanie V" last="Blank">Stephanie V. Blank</name>
<affiliation wicri:level="1"><nlm:aff id="A56"> New York University School of Medicine, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> New York University School of Medicine, New York, New York</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name>
<affiliation wicri:level="1"><nlm:aff id="A57"> The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea> The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kaufman, Bella" sort="Kaufman, Bella" uniqKey="Kaufman B" first="Bella" last="Kaufman">Bella Kaufman</name>
<affiliation wicri:level="1"><nlm:aff id="A58"> Oncology Institute, Sheba Medical Center, Tel-Hashomer, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea> Oncology Institute, Sheba Medical Center, Tel-Hashomer</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Laitman, Yael" sort="Laitman, Yael" uniqKey="Laitman Y" first="Yael" last="Laitman">Yael Laitman</name>
<affiliation wicri:level="1"><nlm:aff id="A57"> The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea> The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Milgrom, Roni" sort="Milgrom, Roni" uniqKey="Milgrom R" first="Roni" last="Milgrom">Roni Milgrom</name>
<affiliation wicri:level="1"><nlm:aff id="A57"> The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea> The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L" last="Andrulis">Irene L. Andrulis</name>
<affiliation wicri:level="1"><nlm:aff id="A59"> Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea> Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A60"> Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea> Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A61"> Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea> Department of Molecular Genetics, University of Toronto, Toronto, Ontario</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name>
<affiliation wicri:level="1"><nlm:aff id="A59"> Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea> Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ozcelik, Hilmi" sort="Ozcelik, Hilmi" uniqKey="Ozcelik H" first="Hilmi" last="Ozcelik">Hilmi Ozcelik</name>
<affiliation wicri:level="1"><nlm:aff id="A60"> Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea> Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kirchhoff, Tomas" sort="Kirchhoff, Tomas" uniqKey="Kirchhoff T" first="Tomas" last="Kirchhoff">Tomas Kirchhoff</name>
<affiliation wicri:level="1"><nlm:aff id="A62"> Clinical Genetics Service, Memorial Hospital, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Clinical Genetics Service, Memorial Hospital, New York, New York</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A63"> Cancer Biology and Genetics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Cancer Biology and Genetics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vijai, Joseph" sort="Vijai, Joseph" uniqKey="Vijai J" first="Joseph" last="Vijai">Joseph Vijai</name>
<affiliation wicri:level="1"><nlm:aff id="A62"> Clinical Genetics Service, Memorial Hospital, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Clinical Genetics Service, Memorial Hospital, New York, New York</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A63"> Cancer Biology and Genetics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Cancer Biology and Genetics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M" last="Gaudet">Mia M. Gaudet</name>
<affiliation wicri:level="1"><nlm:aff id="A64"> Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, New York</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A65"> Department of Obstetrics and Gynecology and Women’s Health, Albert Einstein College of Medicine, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Obstetrics and Gynecology and Women’s Health, Albert Einstein College of Medicine, New York, New York</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Altshuler, David" sort="Altshuler, David" uniqKey="Altshuler D" first="David" last="Altshuler">David Altshuler</name>
<affiliation wicri:level="1"><nlm:aff id="A66"> Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Guiducci, Candace" sort="Guiducci, Candace" uniqKey="Guiducci C" first="Candace" last="Guiducci">Candace Guiducci</name>
<affiliation wicri:level="1"><nlm:aff id="A66"> Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Loman, Niklas" sort="Loman, Niklas" uniqKey="Loman N" first="Niklas" last="Loman">Niklas Loman</name>
<affiliation wicri:level="1"><nlm:aff id="A68"> Department of Oncology, Lund University, Lund, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea> Department of Oncology, Lund University, Lund</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Harbst, Katja" sort="Harbst, Katja" uniqKey="Harbst K" first="Katja" last="Harbst">Katja Harbst</name>
<affiliation wicri:level="1"><nlm:aff id="A68"> Department of Oncology, Lund University, Lund, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea> Department of Oncology, Lund University, Lund</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rantala, Johanna" sort="Rantala, Johanna" uniqKey="Rantala J" first="Johanna" last="Rantala">Johanna Rantala</name>
<affiliation wicri:level="1"><nlm:aff id="A69"> Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea> Department of Clinical Genetics, Karolinska University Hospital, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ehrencrona, Hans" sort="Ehrencrona, Hans" uniqKey="Ehrencrona H" first="Hans" last="Ehrencrona">Hans Ehrencrona</name>
<affiliation wicri:level="1"><nlm:aff id="A70"> Department of Genetics and Pathology Rudbeck Laboratory, Uppsala University, Uppsala, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea> Department of Genetics and Pathology Rudbeck Laboratory, Uppsala University, Uppsala</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gerdes, Anne Marie" sort="Gerdes, Anne Marie" uniqKey="Gerdes A" first="Anne-Marie" last="Gerdes">Anne-Marie Gerdes</name>
<affiliation wicri:level="1"><nlm:aff id="A71"> Department of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea> Department of Clinical Genetics, Rigshospitalet, Copenhagen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name>
<affiliation wicri:level="1"><nlm:aff id="A72"> Department of Clinical Genetics, Odense University Hospital, Odense, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea> Department of Clinical Genetics, Odense University Hospital, Odense</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sunde, Lone" sort="Sunde, Lone" uniqKey="Sunde L" first="Lone" last="Sunde">Lone Sunde</name>
<affiliation wicri:level="1"><nlm:aff id="A73"> Department of Clinical Genetics, Aalborg and Aarhus University Hospital, Aaarhus, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea> Department of Clinical Genetics, Aalborg and Aarhus University Hospital, Aaarhus</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name>
<affiliation wicri:level="1"><nlm:aff id="A74"> Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale Tumori (INT), Milan</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A75"> IFOM, Fondazione Istituto Fondazione Italiana per la Ricera sul Cancro (FIRC) di Oncologia Molecolare, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> IFOM, Fondazione Istituto Fondazione Italiana per la Ricera sul Cancro (FIRC) di Oncologia Molecolare, Milan</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name>
<affiliation wicri:level="1"><nlm:aff id="A76"> Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name>
<affiliation wicri:level="1"><nlm:aff id="A77"> Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Viel, Alessandra" sort="Viel, Alessandra" uniqKey="Viel A" first="Alessandra" last="Viel">Alessandra Viel</name>
<affiliation wicri:level="1"><nlm:aff id="A78"> Division of Experimental Oncology, Centro di Riferimento Oncologico (CRO), IRCCS, Aviano (PN), Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> Division of Experimental Oncology, Centro di Riferimento Oncologico (CRO), IRCCS, Aviano (PN)</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name>
<affiliation wicri:level="1"><nlm:aff id="A74"> Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale Tumori (INT), Milan</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A75"> IFOM, Fondazione Istituto Fondazione Italiana per la Ricera sul Cancro (FIRC) di Oncologia Molecolare, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> IFOM, Fondazione Istituto Fondazione Italiana per la Ricera sul Cancro (FIRC) di Oncologia Molecolare, Milan</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Caldes, Trinidad" sort="Caldes, Trinidad" uniqKey="Caldes T" first="Trinidad" last="Caldes">Trinidad Caldes</name>
<affiliation wicri:level="1"><nlm:aff id="A79"> Hospital Clinico San Carlos, Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea> Hospital Clinico San Carlos, Madrid</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De La Hoya, Miguel" sort="De La Hoya, Miguel" uniqKey="De La Hoya M" first="Miguel" last="De La Hoya">Miguel De La Hoya</name>
<affiliation wicri:level="1"><nlm:aff id="A77"> Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Singer, Christian F" sort="Singer, Christian F" uniqKey="Singer C" first="Christian F" last="Singer">Christian F. Singer</name>
<affiliation wicri:level="1"><nlm:aff id="A80"> Department of Obstetrics/Gynocology, Medical University of Vienna, Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea> Department of Obstetrics/Gynocology, Medical University of Vienna, Vienna</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fink Retter, Anneliese" sort="Fink Retter, Anneliese" uniqKey="Fink Retter A" first="Anneliese" last="Fink-Retter">Anneliese Fink-Retter</name>
<affiliation wicri:level="1"><nlm:aff id="A80"> Department of Obstetrics/Gynocology, Medical University of Vienna, Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea> Department of Obstetrics/Gynocology, Medical University of Vienna, Vienna</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H" last="Greene">Mark H. Greene</name>
<affiliation wicri:level="1"><nlm:aff id="A81"> Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L" last="Mai">Phuong L. Mai</name>
<affiliation wicri:level="1"><nlm:aff id="A81"> Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Loud, Jennifer T" sort="Loud, Jennifer T" uniqKey="Loud J" first="Jennifer T" last="Loud">Jennifer T. Loud</name>
<affiliation wicri:level="1"><nlm:aff id="A81"> Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Guidugli, Lucia" sort="Guidugli, Lucia" uniqKey="Guidugli L" first="Lucia" last="Guidugli">Lucia Guidugli</name>
<affiliation wicri:level="1"><nlm:aff id="A2"> Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lindor, Noralane M" sort="Lindor, Noralane M" uniqKey="Lindor N" first="Noralane M" last="Lindor">Noralane M. Lindor</name>
<affiliation wicri:level="1"><nlm:aff id="A82"> Medical Genetics, Mayo Clinic Rochester, Rochester, Minnesota, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Medical Genetics, Mayo Clinic Rochester, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hansen, Thomas V O" sort="Hansen, Thomas V O" uniqKey="Hansen T" first="Thomas V O" last="Hansen">Thomas V O. Hansen</name>
<affiliation wicri:level="1"><nlm:aff id="A83"> Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea> Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nielsen, Finn C" sort="Nielsen, Finn C" uniqKey="Nielsen F" first="Finn C" last="Nielsen">Finn C. Nielsen</name>
<affiliation wicri:level="1"><nlm:aff id="A83"> Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea> Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Blanco, Ignacio" sort="Blanco, Ignacio" uniqKey="Blanco I" first="Ignacio" last="Blanco">Ignacio Blanco</name>
<affiliation wicri:level="1"><nlm:aff id="A84"> Hereditary Cancer Program, Catalan Institute of Oncology, Gran Via de l’Hospitalet, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea> Hereditary Cancer Program, Catalan Institute of Oncology, Gran Via de l’Hospitalet, Barcelona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lazaro, Conxi" sort="Lazaro, Conxi" uniqKey="Lazaro C" first="Conxi" last="Lazaro">Conxi Lazaro</name>
<affiliation wicri:level="1"><nlm:aff id="A84"> Hereditary Cancer Program, Catalan Institute of Oncology, Gran Via de l’Hospitalet, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea> Hereditary Cancer Program, Catalan Institute of Oncology, Gran Via de l’Hospitalet, Barcelona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Garber, Judy" sort="Garber, Judy" uniqKey="Garber J" first="Judy" last="Garber">Judy Garber</name>
<affiliation wicri:level="1"><nlm:aff id="A85"> Dana-Farber Cancer Institute, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Dana-Farber Cancer Institute, Boston, Massachusetts</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ramus, Susan J" sort="Ramus, Susan J" uniqKey="Ramus S" first="Susan J" last="Ramus">Susan J. Ramus</name>
<affiliation wicri:level="1"><nlm:aff id="A86"> Department of Gynaecological Oncology, University College London, Elizabeth Garrett Anderson (EGA) Institute for Women’s Health, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Department of Gynaecological Oncology, University College London, Elizabeth Garrett Anderson (EGA) Institute for Women’s Health, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gayther, Simon A" sort="Gayther, Simon A" uniqKey="Gayther S" first="Simon A" last="Gayther">Simon A. Gayther</name>
<affiliation wicri:level="1"><nlm:aff id="A86"> Department of Gynaecological Oncology, University College London, Elizabeth Garrett Anderson (EGA) Institute for Women’s Health, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Department of Gynaecological Oncology, University College London, Elizabeth Garrett Anderson (EGA) Institute for Women’s Health, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Phelan, Catherine" sort="Phelan, Catherine" uniqKey="Phelan C" first="Catherine" last="Phelan">Catherine Phelan</name>
<affiliation wicri:level="1"><nlm:aff id="A87"> Women’s College Research Institute, Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea> Women’s College Research Institute, Toronto, Ontario</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Narod, Stephen" sort="Narod, Stephen" uniqKey="Narod S" first="Stephen" last="Narod">Stephen Narod</name>
<affiliation wicri:level="1"><nlm:aff id="A88"> Department of Epidemiology and Genetics, H. Lee Moffitt Cancer Center, Tampa, Florida, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Epidemiology and Genetics, H. Lee Moffitt Cancer Center, Tampa, Florida</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Szabo, Csilla I" sort="Szabo, Csilla I" uniqKey="Szabo C" first="Csilla I" last="Szabo">Csilla I. Szabo</name>
<affiliation wicri:level="1"><nlm:aff id="A2"> Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name>
<affiliation wicri:level="1"><nlm:aff id="A90"> Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea> Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name>
<affiliation wicri:level="1"><nlm:aff id="A90"> Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea> Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name>
<affiliation wicri:level="1"><nlm:aff id="A91"> Helsinki University Central Hospital, Department of Obstetrics and Gynecology, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea> Helsinki University Central Hospital, Department of Obstetrics and Gynecology, Helsinki</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Heikkinen, Tuomas" sort="Heikkinen, Tuomas" uniqKey="Heikkinen T" first="Tuomas" last="Heikkinen">Tuomas Heikkinen</name>
<affiliation wicri:level="1"><nlm:aff id="A91"> Helsinki University Central Hospital, Department of Obstetrics and Gynecology, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea> Helsinki University Central Hospital, Department of Obstetrics and Gynecology, Helsinki</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Caligo, Maria A" sort="Caligo, Maria A" uniqKey="Caligo M" first="Maria A" last="Caligo">Maria A. Caligo</name>
<affiliation wicri:level="1"><nlm:aff id="A92"> Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, Pisa University Hospital, Pisa, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, Pisa University Hospital, Pisa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Beattie, Mary S" sort="Beattie, Mary S" uniqKey="Beattie M" first="Mary S" last="Beattie">Mary S. Beattie</name>
<affiliation wicri:level="1"><nlm:aff id="A93"> Department of Medicine, University of California, San Francisco, San Francisco, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Medicine, University of California, San Francisco, San Francisco, California</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A94"> Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A95"> Cancer Risk Program, Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Cancer Risk Program, Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name>
<affiliation wicri:level="1"><nlm:aff id="A96"> German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K" last="Godwin">Andrew K. Godwin</name>
<affiliation wicri:level="1"><nlm:aff id="A39"> Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Fox Chase Cancer Center, Philadelphia, Pennsylvania</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name>
<affiliation wicri:level="1"><nlm:aff id="A97"> Istituto Oncologico Veneto-IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> Istituto Oncologico Veneto-IRCCS, Immunology and Molecular Oncology Unit, Padua</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Casella, Cinzia" sort="Casella, Cinzia" uniqKey="Casella C" first="Cinzia" last="Casella">Cinzia Casella</name>
<affiliation wicri:level="1"><nlm:aff id="A97"> Istituto Oncologico Veneto-IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> Istituto Oncologico Veneto-IRCCS, Immunology and Molecular Oncology Unit, Padua</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L" last="Neuhausen">Susan L. Neuhausen</name>
<affiliation wicri:level="1"><nlm:aff id="A98"> Department of Population Sciences, The Beckman Research Institute of the City of Hope, Duarte, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Population Sciences, The Beckman Research Institute of the City of Hope, Duarte, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Karlan, Beth Y" sort="Karlan, Beth Y" uniqKey="Karlan B" first="Beth Y" last="Karlan">Beth Y. Karlan</name>
<affiliation wicri:level="1"><nlm:aff id="A99"> Women’s Cancer Research Institute at the Samuel Oschin Cancer Institute, Division of Gynecologic Oncology, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Women’s Cancer Research Institute at the Samuel Oschin Cancer Institute, Division of Gynecologic Oncology, Cedars-Sinai Medical Center, Los Angeles, California</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A100"> Department of Obstetrics and Gynecology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Obstetrics and Gynecology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tung, Nadine" sort="Tung, Nadine" uniqKey="Tung N" first="Nadine" last="Tung">Nadine Tung</name>
<affiliation wicri:level="1"><nlm:aff id="A101"> Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Beth Israel Deaconess Medical Center, Boston, Massachusetts</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E" last="Toland">Amanda E. Toland</name>
<affiliation wicri:level="1"><nlm:aff id="A102"> Comprehensive Cancer Center, Department of Molecular Virology, Immunology and Medical Genetics, Division of Human Genetics, Department of Internal Medicine, Ohio State University, Columbus, Ohio, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Comprehensive Cancer Center, Department of Molecular Virology, Immunology and Medical Genetics, Division of Human Genetics, Department of Internal Medicine, Ohio State University, Columbus, Ohio</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Weitzel, Jeffrey" sort="Weitzel, Jeffrey" uniqKey="Weitzel J" first="Jeffrey" last="Weitzel">Jeffrey Weitzel</name>
<affiliation wicri:level="1"><nlm:aff id="A103"> Division of Clinical Cancer Genetics, City of Hope Cancer Center, Duarte, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Division of Clinical Cancer Genetics, City of Hope Cancer Center, Duarte, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Olopade, Olofunmilayo" sort="Olopade, Olofunmilayo" uniqKey="Olopade O" first="Olofunmilayo" last="Olopade">Olofunmilayo Olopade</name>
<affiliation wicri:level="1"><nlm:aff id="A104"> University of Chicago Medical Center, Chicago, Illinois, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> University of Chicago Medical Center, Chicago, Illinois</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name>
<affiliation wicri:level="1"><nlm:aff id="A105"> Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Quebec, Québec City, Quebec, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea> Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Quebec, Québec City, Quebec</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A106"> Université Laval, Centre de recherche du Centre Hospitalier Universitaire de Quebéc (CHUQ), Québec City, Quebec, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea> Université Laval, Centre de recherche du Centre Hospitalier Universitaire de Quebéc (CHUQ), Québec City, Quebec</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name>
<affiliation wicri:level="1"><nlm:aff id="A105"> Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Quebec, Québec City, Quebec, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea> Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Quebec, Québec City, Quebec</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rubinstein, Wendy S" sort="Rubinstein, Wendy S" uniqKey="Rubinstein W" first="Wendy S" last="Rubinstein">Wendy S. Rubinstein</name>
<affiliation wicri:level="1"><nlm:aff id="A107"> Northshore University Health System, Evanston, Illinois, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Northshore University Health System, Evanston, Illinois</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Arason, Adalgeir" sort="Arason, Adalgeir" uniqKey="Arason A" first="Adalgeir" last="Arason">Adalgeir Arason</name>
<affiliation wicri:level="1"><nlm:aff id="A108"> Department of Pathology, Landspitali University Hospital, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea> Department of Pathology, Landspitali University Hospital, Reykjavik</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name>
<affiliation wicri:level="1"><nlm:aff id="A109"> QIMR GWAS Collective, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> QIMR GWAS Collective, Queensland Institute of Medical Research, Brisbane</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name>
<affiliation wicri:level="1"><nlm:aff id="A110"> Clalit Health Services National Cancer Control Center, Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Technion, Haifa, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea> Clalit Health Services National Cancer Control Center, Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Technion, Haifa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W" last="Montgomery">Grant W. Montgomery</name>
<affiliation wicri:level="1"><nlm:aff id="A110"> Clalit Health Services National Cancer Control Center, Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Technion, Haifa, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea> Clalit Health Services National Cancer Control Center, Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Technion, Haifa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name>
<affiliation wicri:level="1"><nlm:aff id="A111"> Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name>
<affiliation wicri:level="1"><nlm:aff id="A112"> Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name>
<affiliation wicri:level="1"><nlm:aff id="A113"> Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A114"> University Tübingen, Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> University Tübingen, Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
<affiliation wicri:level="1"><nlm:aff id="A116"> Melbourne Collaborative Cohort Study (MCCS), Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> Melbourne Collaborative Cohort Study (MCCS), Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name>
<affiliation wicri:level="1"><nlm:aff id="A116"> Melbourne Collaborative Cohort Study (MCCS), Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> Melbourne Collaborative Cohort Study (MCCS), Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name>
<affiliation wicri:level="1"><nlm:aff id="A117"> Institute for Cancer Studies, Department of Oncology, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Institute for Cancer Studies, Department of Oncology, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S" last="Cross">Simon S. Cross</name>
<affiliation wicri:level="1"><nlm:aff id="A118"> Academic Unit of Pathology, Department of Neuroscience, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Academic Unit of Pathology, Department of Neuroscience, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Miron, Penelope" sort="Miron, Penelope" uniqKey="Miron P" first="Penelope" last="Miron">Penelope Miron</name>
<affiliation wicri:level="1"><nlm:aff id="A119"> Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gerty, Sue M" sort="Gerty, Sue M" uniqKey="Gerty S" first="Sue M" last="Gerty">Sue M. Gerty</name>
<affiliation wicri:level="1"><nlm:aff id="A7"> Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tapper, William" sort="Tapper, William" uniqKey="Tapper W" first="William" last="Tapper">William Tapper</name>
<affiliation wicri:level="1"><nlm:aff id="A7"> Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name>
<affiliation wicri:level="1"><nlm:aff id="A120"> Molecular Diagnostics Laboratory Institute of Radioisotopes and Radiodiagnostic Products, National Centre for Scientific Research ‘Demokritos’, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea> Molecular Diagnostics Laboratory Institute of Radioisotopes and Radiodiagnostic Products, National Centre for Scientific Research ‘Demokritos’, Athens</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fountzilas, George" sort="Fountzilas, George" uniqKey="Fountzilas G" first="George" last="Fountzilas">George Fountzilas</name>
<affiliation wicri:level="1"><nlm:aff id="A121"> Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea> Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A122"> Hellenic Cooperative Oncology Group, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea> Hellenic Cooperative Oncology Group</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A" last="Fasching">Peter A. Fasching</name>
<affiliation wicri:level="1"><nlm:aff id="A123"> University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, Los Angeles, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W" last="Beckmann">Matthias W. Beckmann</name>
<affiliation wicri:level="1"><nlm:aff id="A124"> University Hospital Erlangen, Department of Gynecology and Obstetrics, Erlangen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> University Hospital Erlangen, Department of Gynecology and Obstetrics, Erlangen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Silva, Isabel Dos Santos" sort="Silva, Isabel Dos Santos" uniqKey="Silva I" first="Isabel Dos Santos" last="Silva">Isabel Dos Santos Silva</name>
<affiliation wicri:level="1"><nlm:aff id="A125"> Cancer Research UK Epidemiology and Genetics Group, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Cancer Research UK Epidemiology and Genetics Group, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name>
<affiliation wicri:level="1"><nlm:aff id="A125"> Cancer Research UK Epidemiology and Genetics Group, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Cancer Research UK Epidemiology and Genetics Group, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name>
<affiliation wicri:level="1"><nlm:aff id="A126"> Vesalius Research Center (VRC), VIB, Leuven, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea> Vesalius Research Center (VRC), VIB, Leuven</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Paridaens, Robert" sort="Paridaens, Robert" uniqKey="Paridaens R" first="Robert" last="Paridaens">Robert Paridaens</name>
<affiliation wicri:level="1"><nlm:aff id="A127"> Multidisciplinary Breast Center, University Hospitals Leuven, Leuven, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea> Multidisciplinary Breast Center, University Hospitals Leuven, Leuven</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rudiger, Thomas" sort="Rudiger, Thomas" uniqKey="Rudiger T" first="Thomas" last="Rüdiger">Thomas Rüdiger</name>
<affiliation wicri:level="1"><nlm:aff id="A128"> Institute of Pathology, Städtisches Klinikum Karlsruhe, Karlsruhe, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Institute of Pathology, Städtisches Klinikum Karlsruhe, Karlsruhe</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Forsti, Asta" sort="Forsti, Asta" uniqKey="Forsti A" first="Asta" last="Försti">Asta Försti</name>
<affiliation wicri:level="1"><nlm:aff id="A96"> German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A129"> Center for Primary Health Care Research, University of Lund, Lund, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea> Center for Primary Health Care Research, University of Lund, Lund</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name>
<affiliation wicri:level="1"><nlm:aff id="A130"> Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea> Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name>
<affiliation wicri:level="1"><nlm:aff id="A130"> Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea> Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Diasio, Robert B" sort="Diasio, Robert B" uniqKey="Diasio R" first="Robert B" last="Diasio">Robert B. Diasio</name>
<affiliation wicri:level="1"><nlm:aff id="A131"> Department of Pharmacology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Pharmacology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lee, Adam M" sort="Lee, Adam M" uniqKey="Lee A" first="Adam M" last="Lee">Adam M. Lee</name>
<affiliation wicri:level="1"><nlm:aff id="A131"> Department of Pharmacology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Pharmacology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eckel Passow, Jeanette" sort="Eckel Passow, Jeanette" uniqKey="Eckel Passow J" first="Jeanette" last="Eckel-Passow">Jeanette Eckel-Passow</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Blows, Fiona" sort="Blows, Fiona" uniqKey="Blows F" first="Fiona" last="Blows">Fiona Blows</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Driver, Kristy" sort="Driver, Kristy" uniqKey="Driver K" first="Kristy" last="Driver">Kristy Driver</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dunning, Alison" sort="Dunning, Alison" uniqKey="Dunning A" first="Alison" last="Dunning">Alison Dunning</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pharoah, Paul P D" sort="Pharoah, Paul P D" uniqKey="Pharoah P" first="Paul P D" last="Pharoah">Paul P D. Pharoah</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name>
<affiliation wicri:level="1"><nlm:aff id="A61"> Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea> Department of Molecular Genetics, University of Toronto, Toronto, Ontario</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pankratz, V Shane" sort="Pankratz, V Shane" uniqKey="Pankratz V" first="V Shane" last="Pankratz">V Shane Pankratz</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name>
<affiliation wicri:level="1"><nlm:aff id="A132"> Center for Applied Genomics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Center for Applied Genomics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
<affiliation wicri:level="1"><nlm:aff id="A6"> Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> Queensland Institute of Medical Research, Brisbane</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F" last="Easton">Douglas F. Easton</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J" last="Couch">Fergus J. Couch</name>
<affiliation wicri:level="1"><nlm:aff id="A2"> Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature genetics</title>
<idno type="ISSN">1061-4036</idno>
<idno type="eISSN">1546-1718</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Germline <italic>BRCA1</italic>
 mutations predispose to breast cancer. To identify genetic modifiers of this risk, we performed a genome-wide association study in 1,193 individuals with <italic>BRCA1</italic>
 mutations who were diagnosed with invasive breast cancer under age 40 and 1,190 <italic>BRCA1</italic>
 carriers without breast cancer diagnosis over age 35. We took forward 96 SNPs for replication in another 5,986 <italic>BRCA1</italic>
 carriers (2,974 individuals with breast cancer and 3,012 unaffected individuals). Five SNPs on 19p13 were associated with breast cancer risk (<italic>P</italic>
<sub>trend</sub>
 = 2.3 × 10<sup>−9</sup>
 to <italic>P</italic>
<sub>trend</sub>
 = 3.9 × 10<sup>−7</sup>
), two of which showed independent associations (rs8170, hazard ratio (HR) = 1.26, 95% CI 1.17–1.35; rs2363956 HR = 0.84, 95% CI 0.80–0.89). Genotyping these SNPs in 6,800 population-based breast cancer cases and 6,613 controls identified a similar association with estrogen receptor–negative breast cancer (rs2363956 per-allele odds ratio (OR) = 0.83, 95% CI 0.75–0.92, <italic>P</italic>
<sub>trend</sub>
 = 0.0003) and an association with estrogen receptor–positive disease in the opposite direction (OR = 1.07, 95% CI 1.01–1.14, <italic>P</italic>
<sub>trend</sub>
 = 0.016). The five SNPs were also associated with triple-negative breast cancer in a separate study of 2,301 triple-negative cases and 3,949 controls (<italic>P</italic>
<sub>trend</sub>
 = 1 × 10<sup>−7</sup>
 to <italic>P</italic>
<sub>trend</sub>
 = 8 × 10<sup>−5</sup>
; rs2363956 per-allele OR = 0.80, 95% CI 0.74–0.87, <italic>P</italic>
<sub>trend</sub>
 = 1.1 × 10<sup>−7</sup>
).</p>
</div>
</front>
</TEI>
<pmc article-type="research-article" xml:lang="en"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">9216904</journal-id>
<journal-id journal-id-type="pubmed-jr-id">2419</journal-id>
<journal-id journal-id-type="nlm-ta">Nat Genet</journal-id>
<journal-title-group><journal-title>Nature genetics</journal-title>
</journal-title-group>
<issn pub-type="ppub">1061-4036</issn>
<issn pub-type="epub">1546-1718</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">20852631</article-id>
<article-id pub-id-type="pmc">3130795</article-id>
<article-id pub-id-type="doi">10.1038/ng.669</article-id>
<article-id pub-id-type="manuscript">NIHMS287057</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>A locus on 19p13 modifies risk of breast cancer in <italic>BRCA1</italic>
 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Antoniou</surname>
<given-names>Antonis C</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Xianshu</given-names>
</name>
<xref rid="A2" ref-type="aff">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fredericksen</surname>
<given-names>Zachary S</given-names>
</name>
<xref rid="A3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>McGuffog</surname>
<given-names>Lesley</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tarrell</surname>
<given-names>Robert</given-names>
</name>
<xref rid="A3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sinilnikova</surname>
<given-names>Olga M</given-names>
</name>
<xref rid="A4" ref-type="aff">4</xref>
<xref rid="A5" ref-type="aff">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Healey</surname>
<given-names>Sue</given-names>
</name>
<xref rid="A6" ref-type="aff">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Morrison</surname>
<given-names>Jonathan</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kartsonaki</surname>
<given-names>Christiana</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lesnick</surname>
<given-names>Timothy</given-names>
</name>
<xref rid="A3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ghoussaini</surname>
<given-names>Maya</given-names>
</name>
<xref rid="A6" ref-type="aff">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Barrowdale</surname>
<given-names>Daniel</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><collab>EMBRACE</collab>
<xref rid="A1" ref-type="aff">1</xref>
<xref rid="FN2" ref-type="author-notes">133</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Peock</surname>
<given-names>Susan</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cook</surname>
<given-names>Margaret</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Oliver</surname>
<given-names>Clare</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Frost</surname>
<given-names>Debra</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Eccles</surname>
<given-names>Diana</given-names>
</name>
<xref rid="A7" ref-type="aff">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Evans</surname>
<given-names>D Gareth</given-names>
</name>
<xref rid="A8" ref-type="aff">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Eeles</surname>
<given-names>Ros</given-names>
</name>
<xref rid="A9" ref-type="aff">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Izatt</surname>
<given-names>Louise</given-names>
</name>
<xref rid="A10" ref-type="aff">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chu</surname>
<given-names>Carol</given-names>
</name>
<xref rid="A11" ref-type="aff">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Douglas</surname>
<given-names>Fiona</given-names>
</name>
<xref rid="A12" ref-type="aff">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Paterson</surname>
<given-names>Joan</given-names>
</name>
<xref rid="A13" ref-type="aff">13</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Stoppa-Lyonnet</surname>
<given-names>Dominique</given-names>
</name>
<xref rid="A14" ref-type="aff">14</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Houdayer</surname>
<given-names>Claude</given-names>
</name>
<xref rid="A14" ref-type="aff">14</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mazoyer</surname>
<given-names>Sylvie</given-names>
</name>
<xref rid="A5" ref-type="aff">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Giraud</surname>
<given-names>Sophie</given-names>
</name>
<xref rid="A4" ref-type="aff">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lasset</surname>
<given-names>Christine</given-names>
</name>
<xref rid="A15" ref-type="aff">15</xref>
<xref rid="A16" ref-type="aff">16</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Remenieras</surname>
<given-names>Audrey</given-names>
</name>
<xref rid="A17" ref-type="aff">17</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Caron</surname>
<given-names>Olivier</given-names>
</name>
<xref rid="A18" ref-type="aff">18</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hardouin</surname>
<given-names>Agnès</given-names>
</name>
<xref rid="A19" ref-type="aff">19</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Berthet</surname>
<given-names>Pascaline</given-names>
</name>
<xref rid="A19" ref-type="aff">19</xref>
</contrib>
<contrib contrib-type="author"><collab>GEMO Study Collaborators</collab>
<xref rid="A20" ref-type="aff">20</xref>
<xref rid="FN2" ref-type="author-notes">133</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hogervorst</surname>
<given-names>Frans B L</given-names>
</name>
<xref rid="A21" ref-type="aff">21</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rookus</surname>
<given-names>Matti A</given-names>
</name>
<xref rid="A22" ref-type="aff">22</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jager</surname>
<given-names>Agnes</given-names>
</name>
<xref rid="A23" ref-type="aff">23</xref>
</contrib>
<contrib contrib-type="author"><name><surname>van den Ouweland</surname>
<given-names>Ans</given-names>
</name>
<xref rid="A24" ref-type="aff">24</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hoogerbrugge</surname>
<given-names>Nicoline</given-names>
</name>
<xref rid="A25" ref-type="aff">25</xref>
</contrib>
<contrib contrib-type="author"><name><surname>van der Luijt</surname>
<given-names>Rob B</given-names>
</name>
<xref rid="A26" ref-type="aff">26</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Meijers-Heijboer</surname>
<given-names>Hanne</given-names>
</name>
<xref rid="A27" ref-type="aff">27</xref>
</contrib>
<contrib contrib-type="author"><name><surname>García</surname>
<given-names>Encarna B Gómez</given-names>
</name>
<xref rid="A28" ref-type="aff">28</xref>
</contrib>
<contrib contrib-type="author"><collab>HEBON</collab>
<xref rid="A29" ref-type="aff">29</xref>
<xref rid="FN2" ref-type="author-notes">133</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Devilee</surname>
<given-names>Peter</given-names>
</name>
<xref rid="A30" ref-type="aff">30</xref>
<xref rid="A31" ref-type="aff">31</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vreeswijk</surname>
<given-names>Maaike P G</given-names>
</name>
<xref rid="A32" ref-type="aff">32</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lubinski</surname>
<given-names>Jan</given-names>
</name>
<xref rid="A33" ref-type="aff">33</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jakubowska</surname>
<given-names>Anna</given-names>
</name>
<xref rid="A33" ref-type="aff">33</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gronwald</surname>
<given-names>Jacek</given-names>
</name>
<xref rid="A33" ref-type="aff">33</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Huzarski</surname>
<given-names>Tomasz</given-names>
</name>
<xref rid="A33" ref-type="aff">33</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Byrski</surname>
<given-names>Tomasz</given-names>
</name>
<xref rid="A33" ref-type="aff">33</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Górski</surname>
<given-names>Bohdan</given-names>
</name>
<xref rid="A33" ref-type="aff">33</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cybulski</surname>
<given-names>Cezary</given-names>
</name>
<xref rid="A33" ref-type="aff">33</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Spurdle</surname>
<given-names>Amanda B</given-names>
</name>
<xref rid="A6" ref-type="aff">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Holland</surname>
<given-names>Helene</given-names>
</name>
<xref rid="A6" ref-type="aff">6</xref>
</contrib>
<contrib contrib-type="author"><collab>kConFab</collab>
<xref rid="A34" ref-type="aff">34</xref>
<xref rid="FN2" ref-type="author-notes">133</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Goldgar</surname>
<given-names>David E</given-names>
</name>
<xref rid="A35" ref-type="aff">35</xref>
</contrib>
<contrib contrib-type="author"><name><surname>John</surname>
<given-names>Esther M</given-names>
</name>
<xref rid="A36" ref-type="aff">36</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hopper</surname>
<given-names>John L</given-names>
</name>
<xref rid="A37" ref-type="aff">37</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Southey</surname>
<given-names>Melissa</given-names>
</name>
<xref rid="A37" ref-type="aff">37</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Buys</surname>
<given-names>Saundra S</given-names>
</name>
<xref rid="A38" ref-type="aff">38</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Daly</surname>
<given-names>Mary B</given-names>
</name>
<xref rid="A39" ref-type="aff">39</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Terry</surname>
<given-names>Mary-Beth</given-names>
</name>
<xref rid="A40" ref-type="aff">40</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schmutzler</surname>
<given-names>Rita K</given-names>
</name>
<xref rid="A41" ref-type="aff">41</xref>
<xref rid="A42" ref-type="aff">42</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wappenschmidt</surname>
<given-names>Barbara</given-names>
</name>
<xref rid="A41" ref-type="aff">41</xref>
<xref rid="A42" ref-type="aff">42</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Engel</surname>
<given-names>Christoph</given-names>
</name>
<xref rid="A43" ref-type="aff">43</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Meindl</surname>
<given-names>Alfons</given-names>
</name>
<xref rid="A44" ref-type="aff">44</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Preisler-Adams</surname>
<given-names>Sabine</given-names>
</name>
<xref rid="A45" ref-type="aff">45</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Arnold</surname>
<given-names>Norbert</given-names>
</name>
<xref rid="A46" ref-type="aff">46</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Niederacher</surname>
<given-names>Dieter</given-names>
</name>
<xref rid="A47" ref-type="aff">47</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sutter</surname>
<given-names>Christian</given-names>
</name>
<xref rid="A48" ref-type="aff">48</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Domchek</surname>
<given-names>Susan M</given-names>
</name>
<xref rid="A49" ref-type="aff">49</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nathanson</surname>
<given-names>Katherine L</given-names>
</name>
<xref rid="A49" ref-type="aff">49</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rebbeck</surname>
<given-names>Timothy</given-names>
</name>
<xref rid="A49" ref-type="aff">49</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Blum</surname>
<given-names>Joanne L</given-names>
</name>
<xref rid="A50" ref-type="aff">50</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Piedmonte</surname>
<given-names>Marion</given-names>
</name>
<xref rid="A51" ref-type="aff">51</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rodriguez</surname>
<given-names>Gustavo C</given-names>
</name>
<xref rid="A52" ref-type="aff">52</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wakeley</surname>
<given-names>Katie</given-names>
</name>
<xref rid="A53" ref-type="aff">53</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Boggess</surname>
<given-names>John F</given-names>
</name>
<xref rid="A54" ref-type="aff">54</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Basil</surname>
<given-names>Jack</given-names>
</name>
<xref rid="A55" ref-type="aff">55</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Blank</surname>
<given-names>Stephanie V</given-names>
</name>
<xref rid="A56" ref-type="aff">56</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Friedman</surname>
<given-names>Eitan</given-names>
</name>
<xref rid="A57" ref-type="aff">57</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kaufman</surname>
<given-names>Bella</given-names>
</name>
<xref rid="A58" ref-type="aff">58</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Laitman</surname>
<given-names>Yael</given-names>
</name>
<xref rid="A57" ref-type="aff">57</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Milgrom</surname>
<given-names>Roni</given-names>
</name>
<xref rid="A57" ref-type="aff">57</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Andrulis</surname>
<given-names>Irene L</given-names>
</name>
<xref rid="A59" ref-type="aff">59</xref>
<xref rid="A60" ref-type="aff">60</xref>
<xref rid="A61" ref-type="aff">61</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Glendon</surname>
<given-names>Gord</given-names>
</name>
<xref rid="A59" ref-type="aff">59</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ozcelik</surname>
<given-names>Hilmi</given-names>
</name>
<xref rid="A60" ref-type="aff">60</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kirchhoff</surname>
<given-names>Tomas</given-names>
</name>
<xref rid="A62" ref-type="aff">62</xref>
<xref rid="A63" ref-type="aff">63</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vijai</surname>
<given-names>Joseph</given-names>
</name>
<xref rid="A62" ref-type="aff">62</xref>
<xref rid="A63" ref-type="aff">63</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gaudet</surname>
<given-names>Mia M</given-names>
</name>
<xref rid="A64" ref-type="aff">64</xref>
<xref rid="A65" ref-type="aff">65</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Altshuler</surname>
<given-names>David</given-names>
</name>
<xref rid="A66" ref-type="aff">66</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Guiducci</surname>
<given-names>Candace</given-names>
</name>
<xref rid="A66" ref-type="aff">66</xref>
</contrib>
<contrib contrib-type="author"><collab>SWE-BRCA</collab>
<xref rid="A67" ref-type="aff">67</xref>
<xref rid="FN2" ref-type="author-notes">133</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Loman</surname>
<given-names>Niklas</given-names>
</name>
<xref rid="A68" ref-type="aff">68</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Harbst</surname>
<given-names>Katja</given-names>
</name>
<xref rid="A68" ref-type="aff">68</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rantala</surname>
<given-names>Johanna</given-names>
</name>
<xref rid="A69" ref-type="aff">69</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ehrencrona</surname>
<given-names>Hans</given-names>
</name>
<xref rid="A70" ref-type="aff">70</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gerdes</surname>
<given-names>Anne-Marie</given-names>
</name>
<xref rid="A71" ref-type="aff">71</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Thomassen</surname>
<given-names>Mads</given-names>
</name>
<xref rid="A72" ref-type="aff">72</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sunde</surname>
<given-names>Lone</given-names>
</name>
<xref rid="A73" ref-type="aff">73</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Peterlongo</surname>
<given-names>Paolo</given-names>
</name>
<xref rid="A74" ref-type="aff">74</xref>
<xref rid="A75" ref-type="aff">75</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Manoukian</surname>
<given-names>Siranoush</given-names>
</name>
<xref rid="A76" ref-type="aff">76</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bonanni</surname>
<given-names>Bernardo</given-names>
</name>
<xref rid="A77" ref-type="aff">77</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Viel</surname>
<given-names>Alessandra</given-names>
</name>
<xref rid="A78" ref-type="aff">78</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Radice</surname>
<given-names>Paolo</given-names>
</name>
<xref rid="A74" ref-type="aff">74</xref>
<xref rid="A75" ref-type="aff">75</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Caldes</surname>
<given-names>Trinidad</given-names>
</name>
<xref rid="A79" ref-type="aff">79</xref>
</contrib>
<contrib contrib-type="author"><name><surname>de la Hoya</surname>
<given-names>Miguel</given-names>
</name>
<xref rid="A77" ref-type="aff">77</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Singer</surname>
<given-names>Christian F</given-names>
</name>
<xref rid="A80" ref-type="aff">80</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fink-Retter</surname>
<given-names>Anneliese</given-names>
</name>
<xref rid="A80" ref-type="aff">80</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Greene</surname>
<given-names>Mark H</given-names>
</name>
<xref rid="A81" ref-type="aff">81</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mai</surname>
<given-names>Phuong L</given-names>
</name>
<xref rid="A81" ref-type="aff">81</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Loud</surname>
<given-names>Jennifer T</given-names>
</name>
<xref rid="A81" ref-type="aff">81</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Guidugli</surname>
<given-names>Lucia</given-names>
</name>
<xref rid="A2" ref-type="aff">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lindor</surname>
<given-names>Noralane M</given-names>
</name>
<xref rid="A82" ref-type="aff">82</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hansen</surname>
<given-names>Thomas V O</given-names>
</name>
<xref rid="A83" ref-type="aff">83</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nielsen</surname>
<given-names>Finn C</given-names>
</name>
<xref rid="A83" ref-type="aff">83</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Blanco</surname>
<given-names>Ignacio</given-names>
</name>
<xref rid="A84" ref-type="aff">84</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lazaro</surname>
<given-names>Conxi</given-names>
</name>
<xref rid="A84" ref-type="aff">84</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Garber</surname>
<given-names>Judy</given-names>
</name>
<xref rid="A85" ref-type="aff">85</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ramus</surname>
<given-names>Susan J</given-names>
</name>
<xref rid="A86" ref-type="aff">86</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gayther</surname>
<given-names>Simon A</given-names>
</name>
<xref rid="A86" ref-type="aff">86</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Phelan</surname>
<given-names>Catherine</given-names>
</name>
<xref rid="A87" ref-type="aff">87</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Narod</surname>
<given-names>Stephen</given-names>
</name>
<xref rid="A88" ref-type="aff">88</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Szabo</surname>
<given-names>Csilla I</given-names>
</name>
<xref rid="A2" ref-type="aff">2</xref>
</contrib>
<contrib contrib-type="author"><collab>MOD SQUAD</collab>
<xref rid="A89" ref-type="aff">89</xref>
<xref rid="FN2" ref-type="author-notes">133</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Benitez</surname>
<given-names>Javier</given-names>
</name>
<xref rid="A90" ref-type="aff">90</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Osorio</surname>
<given-names>Ana</given-names>
</name>
<xref rid="A90" ref-type="aff">90</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nevanlinna</surname>
<given-names>Heli</given-names>
</name>
<xref rid="A91" ref-type="aff">91</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Heikkinen</surname>
<given-names>Tuomas</given-names>
</name>
<xref rid="A91" ref-type="aff">91</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Caligo</surname>
<given-names>Maria A</given-names>
</name>
<xref rid="A92" ref-type="aff">92</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Beattie</surname>
<given-names>Mary S</given-names>
</name>
<xref rid="A93" ref-type="aff">93</xref>
<xref rid="A94" ref-type="aff">94</xref>
<xref rid="A95" ref-type="aff">95</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hamann</surname>
<given-names>Ute</given-names>
</name>
<xref rid="A96" ref-type="aff">96</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Godwin</surname>
<given-names>Andrew K</given-names>
</name>
<xref rid="A39" ref-type="aff">39</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Montagna</surname>
<given-names>Marco</given-names>
</name>
<xref rid="A97" ref-type="aff">97</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Casella</surname>
<given-names>Cinzia</given-names>
</name>
<xref rid="A97" ref-type="aff">97</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Neuhausen</surname>
<given-names>Susan L</given-names>
</name>
<xref rid="A98" ref-type="aff">98</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Karlan</surname>
<given-names>Beth Y</given-names>
</name>
<xref rid="A99" ref-type="aff">99</xref>
<xref rid="A100" ref-type="aff">100</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tung</surname>
<given-names>Nadine</given-names>
</name>
<xref rid="A101" ref-type="aff">101</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Toland</surname>
<given-names>Amanda E</given-names>
</name>
<xref rid="A102" ref-type="aff">102</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Weitzel</surname>
<given-names>Jeffrey</given-names>
</name>
<xref rid="A103" ref-type="aff">103</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Olopade</surname>
<given-names>Olofunmilayo</given-names>
</name>
<xref rid="A104" ref-type="aff">104</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Simard</surname>
<given-names>Jacques</given-names>
</name>
<xref rid="A105" ref-type="aff">105</xref>
<xref rid="A106" ref-type="aff">106</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Soucy</surname>
<given-names>Penny</given-names>
</name>
<xref rid="A105" ref-type="aff">105</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rubinstein</surname>
<given-names>Wendy S</given-names>
</name>
<xref rid="A107" ref-type="aff">107</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Arason</surname>
<given-names>Adalgeir</given-names>
</name>
<xref rid="A108" ref-type="aff">108</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rennert</surname>
<given-names>Gad</given-names>
</name>
<xref rid="A109" ref-type="aff">109</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Martin</surname>
<given-names>Nicholas G</given-names>
</name>
<xref rid="A110" ref-type="aff">110</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Montgomery</surname>
<given-names>Grant W</given-names>
</name>
<xref rid="A110" ref-type="aff">110</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chang-Claude</surname>
<given-names>Jenny</given-names>
</name>
<xref rid="A111" ref-type="aff">111</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Flesch-Janys</surname>
<given-names>Dieter</given-names>
</name>
<xref rid="A112" ref-type="aff">112</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Brauch</surname>
<given-names>Hiltrud</given-names>
</name>
<xref rid="A113" ref-type="aff">113</xref>
<xref rid="A114" ref-type="aff">114</xref>
</contrib>
<contrib contrib-type="author"><collab>GENICA</collab>
<xref rid="A115" ref-type="aff">115</xref>
<xref rid="FN2" ref-type="author-notes">133</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Severi</surname>
<given-names>Gianluca</given-names>
</name>
<xref rid="A116" ref-type="aff">116</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baglietto</surname>
<given-names>Laura</given-names>
</name>
<xref rid="A116" ref-type="aff">116</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cox</surname>
<given-names>Angela</given-names>
</name>
<xref rid="A117" ref-type="aff">117</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cross</surname>
<given-names>Simon S</given-names>
</name>
<xref rid="A118" ref-type="aff">118</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Miron</surname>
<given-names>Penelope</given-names>
</name>
<xref rid="A119" ref-type="aff">119</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gerty</surname>
<given-names>Sue M</given-names>
</name>
<xref rid="A7" ref-type="aff">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tapper</surname>
<given-names>William</given-names>
</name>
<xref rid="A7" ref-type="aff">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yannoukakos</surname>
<given-names>Drakoulis</given-names>
</name>
<xref rid="A120" ref-type="aff">120</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fountzilas</surname>
<given-names>George</given-names>
</name>
<xref rid="A121" ref-type="aff">121</xref>
<xref rid="A122" ref-type="aff">122</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fasching</surname>
<given-names>Peter A</given-names>
</name>
<xref rid="A123" ref-type="aff">123</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Beckmann</surname>
<given-names>Matthias W</given-names>
</name>
<xref rid="A124" ref-type="aff">124</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Silva</surname>
<given-names>Isabel dos Santos</given-names>
</name>
<xref rid="A125" ref-type="aff">125</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Peto</surname>
<given-names>Julian</given-names>
</name>
<xref rid="A125" ref-type="aff">125</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lambrechts</surname>
<given-names>Diether</given-names>
</name>
<xref rid="A126" ref-type="aff">126</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Paridaens</surname>
<given-names>Robert</given-names>
</name>
<xref rid="A127" ref-type="aff">127</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rüdiger</surname>
<given-names>Thomas</given-names>
</name>
<xref rid="A128" ref-type="aff">128</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Försti</surname>
<given-names>Asta</given-names>
</name>
<xref rid="A96" ref-type="aff">96</xref>
<xref rid="A129" ref-type="aff">129</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Winqvist</surname>
<given-names>Robert</given-names>
</name>
<xref rid="A130" ref-type="aff">130</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pylkäs</surname>
<given-names>Katri</given-names>
</name>
<xref rid="A130" ref-type="aff">130</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Diasio</surname>
<given-names>Robert B</given-names>
</name>
<xref rid="A131" ref-type="aff">131</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lee</surname>
<given-names>Adam M</given-names>
</name>
<xref rid="A131" ref-type="aff">131</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Eckel-Passow</surname>
<given-names>Jeanette</given-names>
</name>
<xref rid="A3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vachon</surname>
<given-names>Celine</given-names>
</name>
<xref rid="A3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Blows</surname>
<given-names>Fiona</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Driver</surname>
<given-names>Kristy</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dunning</surname>
<given-names>Alison</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pharoah</surname>
<given-names>Paul P D</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Offit</surname>
<given-names>Kenneth</given-names>
</name>
<xref rid="A61" ref-type="aff">61</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pankratz</surname>
<given-names>V Shane</given-names>
</name>
<xref rid="A3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hakonarson</surname>
<given-names>Hakon</given-names>
</name>
<xref rid="A132" ref-type="aff">132</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chenevix-Trench</surname>
<given-names>Georgia</given-names>
</name>
<xref rid="A6" ref-type="aff">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Easton</surname>
<given-names>Douglas F</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Couch</surname>
<given-names>Fergus J</given-names>
</name>
<xref rid="A2" ref-type="aff">2</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
 Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</aff>
<aff id="A2"><label>2</label>
 Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</aff>
<aff id="A3"><label>3</label>
 Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</aff>
<aff id="A4"><label>4</label>
 Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard, Lyon, France</aff>
<aff id="A5"><label>5</label>
 Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France</aff>
<aff id="A6"><label>6</label>
 Queensland Institute of Medical Research, Brisbane, Australia</aff>
<aff id="A7"><label>7</label>
 Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK</aff>
<aff id="A8"><label>8</label>
 Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals National Health Service (NHSFT) Foundation Trust, Manchester, UK</aff>
<aff id="A9"><label>9</label>
 Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK</aff>
<aff id="A10"><label>10</label>
 Clinical Genetics, Guy’s and St. Thomas’ NHS Foundation Trust, London, UK</aff>
<aff id="A11"><label>11</label>
 Yorkshire Regional Genetics Service, Leeds, UK</aff>
<aff id="A12"><label>12</label>
 Institute of Human Genetics, Centre for Life, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK</aff>
<aff id="A13"><label>13</label>
 Department of Clinical Genetics, East Anglian Regional Genetics Service, Addenbrookes Hospital, Cambridge, UK</aff>
<aff id="A14"><label>14</label>
 INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes, Paris, France</aff>
<aff id="A15"><label>15</label>
 CNRS UMR5558, Université Lyon 1, Lyon, France</aff>
<aff id="A16"><label>16</label>
 Unité de Prévention et d’Epidémiologie Génétique, Centre Léon Bérard, Lyon, France</aff>
<aff id="A17"><label>17</label>
 Genetics Department, Institut de Cancérologie Gustave Roussy, Villejuif, France</aff>
<aff id="A18"><label>18</label>
 Consultation de Génétique, Département de Médecine, Institut de Cancérologie Gustave Roussy, Villejuif, France</aff>
<aff id="A19"><label>19</label>
 Centre François Baclesse, Caen, France</aff>
<aff id="A20"><label>20</label>
 GEMO study, Cancer Genetics Network ‘Groupe Génétique et Cancer’, Fédération Nationale des Centres de Lutte Contre le Cancer, Paris, France</aff>
<aff id="A21"><label>21</label>
 Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, The Netherlands</aff>
<aff id="A22"><label>22</label>
 Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</aff>
<aff id="A23"><label>23</label>
 Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</aff>
<aff id="A24"><label>24</label>
 Department of Clinical Genetics, Rotterdam Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</aff>
<aff id="A25"><label>25</label>
 Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</aff>
<aff id="A26"><label>26</label>
 Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</aff>
<aff id="A27"><label>27</label>
 Department of Clinical Genetics, Vrije Universiteit (VU) Medical Center, Amsterdam, The Netherlands</aff>
<aff id="A28"><label>28</label>
 Department of Clinical Genetics, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands</aff>
<aff id="A29"><label>29</label>
 HEBON, Hereditary Breast and Ovarian Cancer Research Group, The Netherlands</aff>
<aff id="A30"><label>30</label>
 Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</aff>
<aff id="A31"><label>31</label>
 Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands</aff>
<aff id="A32"><label>32</label>
 Department of Toxicogenetics, Leiden University Medical Center, Leiden, The Netherlands</aff>
<aff id="A33"><label>33</label>
 International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</aff>
<aff id="A34"><label>34</label>
 kConFab, Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, Peter MacCallum Cancer Centre, Melbourne, Australia</aff>
<aff id="A35"><label>35</label>
 Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, USA</aff>
<aff id="A36"><label>36</label>
 Cancer Prevention Institute of California, Stanford University School of Medicine, Stanford, California, USA</aff>
<aff id="A37"><label>37</label>
 The University of Melbourne, Melbourne, Australia</aff>
<aff id="A38"><label>38</label>
 Huntsman Cancer Institute, University of Utah Health Sciences Centre, Salt Lake City, Utah, USA</aff>
<aff id="A39"><label>39</label>
 Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA</aff>
<aff id="A40"><label>40</label>
 Columbia University, New York, New York, USA</aff>
<aff id="A41"><label>41</label>
 Centre of Familial Breast and Ovarian Cancer, Department of Obstetrics and Gynaecology, University of Cologne, Cologne, Germany</aff>
<aff id="A42"><label>42</label>
 Centre for Integrated Oncology (CIO), University of Cologne, Cologne, Germany</aff>
<aff id="A43"><label>43</label>
 Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany</aff>
<aff id="A44"><label>44</label>
 Department of Obstetrics and Gynaecology, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Munich, Germany</aff>
<aff id="A45"><label>45</label>
 Institute of Human Genetics, University of Muenster, Muenster, Germany</aff>
<aff id="A46"><label>46</label>
 Department of Obstetrics and Gynaecology, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University, Kiel, Germany</aff>
<aff id="A47"><label>47</label>
 Department of Obstetrics and Gynaecology, Division of Molecular Genetics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Dusseldorf, Germany</aff>
<aff id="A48"><label>48</label>
 Institute of Human Genetics, Division of Molecular Diagnostics, University Heidelberg, Heidelberg, Germany</aff>
<aff id="A49"><label>49</label>
 University of Pennsylvania, Philadelphia, Pennsylvania, USA</aff>
<aff id="A50"><label>50</label>
 Baylor-Charles A. Sammons Cancer Center, Dallas, Texas, USA</aff>
<aff id="A51"><label>51</label>
 Gynecology Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, New York, USA</aff>
<aff id="A52"><label>52</label>
 Northshore University Health System, Evanston Northwestern Healthcare, Evanston, Illinois, USA</aff>
<aff id="A53"><label>53</label>
 Tufts University, New England Medical Center, Boston, Massachusetts, USA</aff>
<aff id="A54"><label>54</label>
 University of North Carolina, Chapel Hill, North Carolina, USA</aff>
<aff id="A55"><label>55</label>
 St. Elizabeth Medical Center, Edgewood, Kentucky, USA</aff>
<aff id="A56"><label>56</label>
 New York University School of Medicine, New York, New York, USA</aff>
<aff id="A57"><label>57</label>
 The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel</aff>
<aff id="A58"><label>58</label>
 Oncology Institute, Sheba Medical Center, Tel-Hashomer, Israel</aff>
<aff id="A59"><label>59</label>
 Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada</aff>
<aff id="A60"><label>60</label>
 Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</aff>
<aff id="A61"><label>61</label>
 Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</aff>
<aff id="A62"><label>62</label>
 Clinical Genetics Service, Memorial Hospital, New York, New York, USA</aff>
<aff id="A63"><label>63</label>
 Cancer Biology and Genetics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, USA</aff>
<aff id="A64"><label>64</label>
 Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, New York, USA</aff>
<aff id="A65"><label>65</label>
 Department of Obstetrics and Gynecology and Women’s Health, Albert Einstein College of Medicine, New York, New York, USA</aff>
<aff id="A66"><label>66</label>
 Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA</aff>
<aff id="A67"><label>67</label>
 SWE-BRCA, Swedish Breast Cancer Study, Sweden</aff>
<aff id="A68"><label>68</label>
 Department of Oncology, Lund University, Lund, Sweden</aff>
<aff id="A69"><label>69</label>
 Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden</aff>
<aff id="A70"><label>70</label>
 Department of Genetics and Pathology Rudbeck Laboratory, Uppsala University, Uppsala, Sweden</aff>
<aff id="A71"><label>71</label>
 Department of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark</aff>
<aff id="A72"><label>72</label>
 Department of Clinical Genetics, Odense University Hospital, Odense, Denmark</aff>
<aff id="A73"><label>73</label>
 Department of Clinical Genetics, Aalborg and Aarhus University Hospital, Aaarhus, Denmark</aff>
<aff id="A74"><label>74</label>
 Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale Tumori (INT), Milan, Italy</aff>
<aff id="A75"><label>75</label>
 IFOM, Fondazione Istituto Fondazione Italiana per la Ricera sul Cancro (FIRC) di Oncologia Molecolare, Milan, Italy</aff>
<aff id="A76"><label>76</label>
 Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy</aff>
<aff id="A77"><label>77</label>
 Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy</aff>
<aff id="A78"><label>78</label>
 Division of Experimental Oncology, Centro di Riferimento Oncologico (CRO), IRCCS, Aviano (PN), Italy</aff>
<aff id="A79"><label>79</label>
 Hospital Clinico San Carlos, Madrid, Spain</aff>
<aff id="A80"><label>80</label>
 Department of Obstetrics/Gynocology, Medical University of Vienna, Vienna, Austria</aff>
<aff id="A81"><label>81</label>
 Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA</aff>
<aff id="A82"><label>82</label>
 Medical Genetics, Mayo Clinic Rochester, Rochester, Minnesota, USA</aff>
<aff id="A83"><label>83</label>
 Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark</aff>
<aff id="A84"><label>84</label>
 Hereditary Cancer Program, Catalan Institute of Oncology, Gran Via de l’Hospitalet, Barcelona, Spain</aff>
<aff id="A85"><label>85</label>
 Dana-Farber Cancer Institute, Boston, Massachusetts, USA</aff>
<aff id="A86"><label>86</label>
 Department of Gynaecological Oncology, University College London, Elizabeth Garrett Anderson (EGA) Institute for Women’s Health, London, UK</aff>
<aff id="A87"><label>87</label>
 Women’s College Research Institute, Toronto, Ontario, Canada</aff>
<aff id="A88"><label>88</label>
 Department of Epidemiology and Genetics, H. Lee Moffitt Cancer Center, Tampa, Florida, USA</aff>
<aff id="A89"><label>89</label>
 MOD SQUAD, Modifier Study of Quantitative Effects on Disease</aff>
<aff id="A90"><label>90</label>
 Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain</aff>
<aff id="A91"><label>91</label>
 Helsinki University Central Hospital, Department of Obstetrics and Gynecology, Helsinki, Finland</aff>
<aff id="A92"><label>92</label>
 Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, Pisa University Hospital, Pisa, Italy</aff>
<aff id="A93"><label>93</label>
 Department of Medicine, University of California, San Francisco, San Francisco, California, USA</aff>
<aff id="A94"><label>94</label>
 Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA</aff>
<aff id="A95"><label>95</label>
 Cancer Risk Program, Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco, California, USA</aff>
<aff id="A96"><label>96</label>
 German Cancer Research Center (DKFZ), Heidelberg, Germany</aff>
<aff id="A97"><label>97</label>
 Istituto Oncologico Veneto-IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy</aff>
<aff id="A98"><label>98</label>
 Department of Population Sciences, The Beckman Research Institute of the City of Hope, Duarte, California, USA</aff>
<aff id="A99"><label>99</label>
 Women’s Cancer Research Institute at the Samuel Oschin Cancer Institute, Division of Gynecologic Oncology, Cedars-Sinai Medical Center, Los Angeles, California, USA</aff>
<aff id="A100"><label>100</label>
 Department of Obstetrics and Gynecology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California, USA</aff>
<aff id="A101"><label>101</label>
 Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA</aff>
<aff id="A102"><label>102</label>
 Comprehensive Cancer Center, Department of Molecular Virology, Immunology and Medical Genetics, Division of Human Genetics, Department of Internal Medicine, Ohio State University, Columbus, Ohio, USA</aff>
<aff id="A103"><label>103</label>
 Division of Clinical Cancer Genetics, City of Hope Cancer Center, Duarte, California, USA</aff>
<aff id="A104"><label>104</label>
 University of Chicago Medical Center, Chicago, Illinois, USA</aff>
<aff id="A105"><label>105</label>
 Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Quebec, Québec City, Quebec, Canada</aff>
<aff id="A106"><label>106</label>
 Université Laval, Centre de recherche du Centre Hospitalier Universitaire de Quebéc (CHUQ), Québec City, Quebec, Canada</aff>
<aff id="A107"><label>107</label>
 Northshore University Health System, Evanston, Illinois, USA</aff>
<aff id="A108"><label>108</label>
 Department of Pathology, Landspitali University Hospital, Reykjavik, Iceland</aff>
<aff id="A109"><label>109</label>
 QIMR GWAS Collective, Queensland Institute of Medical Research, Brisbane, Australia</aff>
<aff id="A110"><label>110</label>
 Clalit Health Services National Cancer Control Center, Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Technion, Haifa, Israel</aff>
<aff id="A111"><label>111</label>
 Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</aff>
<aff id="A112"><label>112</label>
 Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</aff>
<aff id="A113"><label>113</label>
 Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</aff>
<aff id="A114"><label>114</label>
 University Tübingen, Tübingen, Germany</aff>
<aff id="A115"><label>115</label>
 GENICA, Gene Environment Interaction and Breast Cancer in Germany</aff>
<aff id="A116"><label>116</label>
 Melbourne Collaborative Cohort Study (MCCS), Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</aff>
<aff id="A117"><label>117</label>
 Institute for Cancer Studies, Department of Oncology, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK</aff>
<aff id="A118"><label>118</label>
 Academic Unit of Pathology, Department of Neuroscience, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK</aff>
<aff id="A119"><label>119</label>
 Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA</aff>
<aff id="A120"><label>120</label>
 Molecular Diagnostics Laboratory Institute of Radioisotopes and Radiodiagnostic Products, National Centre for Scientific Research ‘Demokritos’, Athens, Greece</aff>
<aff id="A121"><label>121</label>
 Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece</aff>
<aff id="A122"><label>122</label>
 Hellenic Cooperative Oncology Group, Greece</aff>
<aff id="A123"><label>123</label>
 University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, Los Angeles, California, USA</aff>
<aff id="A124"><label>124</label>
 University Hospital Erlangen, Department of Gynecology and Obstetrics, Erlangen, Germany</aff>
<aff id="A125"><label>125</label>
 Cancer Research UK Epidemiology and Genetics Group, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK</aff>
<aff id="A126"><label>126</label>
 Vesalius Research Center (VRC), VIB, Leuven, Belgium</aff>
<aff id="A127"><label>127</label>
 Multidisciplinary Breast Center, University Hospitals Leuven, Leuven, Belgium</aff>
<aff id="A128"><label>128</label>
 Institute of Pathology, Städtisches Klinikum Karlsruhe, Karlsruhe, Germany</aff>
<aff id="A129"><label>129</label>
 Center for Primary Health Care Research, University of Lund, Lund, Sweden</aff>
<aff id="A130"><label>130</label>
 Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu, Finland</aff>
<aff id="A131"><label>131</label>
 Department of Pharmacology, Mayo Clinic, Rochester, Minnesota, USA</aff>
<aff id="A132"><label>132</label>
 Center for Applied Genomics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA</aff>
<author-notes><corresp id="FN1">Correspondence should be addressed to F.J.C. (<email>couch.fergus@mayo.edu</email>
)</corresp>
<fn id="FN2"><label>133</label>
<p>A full list of members is provided in the <xref rid="SD1" ref-type="supplementary-material">supplementary Note</xref>
.</p>
</fn>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>7</day>
<month>4</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="epub"><day>19</day>
<month>9</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="ppub"><month>10</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>1</day>
<month>10</month>
<year>2011</year>
</pub-date>
<volume>42</volume>
<issue>10</issue>
<fpage>885</fpage>
<lpage>892</lpage>
<permissions><copyright-statement>© 2010 Nature America, Inc. All rights reserved.</copyright-statement>
<copyright-year>2010</copyright-year>
</permissions>
<abstract><p id="P1">Germline <italic>BRCA1</italic>
 mutations predispose to breast cancer. To identify genetic modifiers of this risk, we performed a genome-wide association study in 1,193 individuals with <italic>BRCA1</italic>
 mutations who were diagnosed with invasive breast cancer under age 40 and 1,190 <italic>BRCA1</italic>
 carriers without breast cancer diagnosis over age 35. We took forward 96 SNPs for replication in another 5,986 <italic>BRCA1</italic>
 carriers (2,974 individuals with breast cancer and 3,012 unaffected individuals). Five SNPs on 19p13 were associated with breast cancer risk (<italic>P</italic>
<sub>trend</sub>
 = 2.3 × 10<sup>−9</sup>
 to <italic>P</italic>
<sub>trend</sub>
 = 3.9 × 10<sup>−7</sup>
), two of which showed independent associations (rs8170, hazard ratio (HR) = 1.26, 95% CI 1.17–1.35; rs2363956 HR = 0.84, 95% CI 0.80–0.89). Genotyping these SNPs in 6,800 population-based breast cancer cases and 6,613 controls identified a similar association with estrogen receptor–negative breast cancer (rs2363956 per-allele odds ratio (OR) = 0.83, 95% CI 0.75–0.92, <italic>P</italic>
<sub>trend</sub>
 = 0.0003) and an association with estrogen receptor–positive disease in the opposite direction (OR = 1.07, 95% CI 1.01–1.14, <italic>P</italic>
<sub>trend</sub>
 = 0.016). The five SNPs were also associated with triple-negative breast cancer in a separate study of 2,301 triple-negative cases and 3,949 controls (<italic>P</italic>
<sub>trend</sub>
 = 1 × 10<sup>−7</sup>
 to <italic>P</italic>
<sub>trend</sub>
 = 8 × 10<sup>−5</sup>
; rs2363956 per-allele OR = 0.80, 95% CI 0.74–0.87, <italic>P</italic>
<sub>trend</sub>
 = 1.1 × 10<sup>−7</sup>
).</p>
</abstract>
<funding-group><award-group><funding-source country="United States">National Cancer Institute  : NCI</funding-source>
<award-id>U01 CA069638-14 || CA</award-id>
</award-group>
<award-group><funding-source country="United States">National Cancer Institute  : NCI</funding-source>
<award-id>U01 CA069631-14 || CA</award-id>
</award-group>
<award-group><funding-source country="United States">National Cancer Institute  : NCI</funding-source>
<award-id>U01 CA069467-14 || CA</award-id>
</award-group>
<award-group><funding-source country="United States">National Cancer Institute  : NCI</funding-source>
<award-id>U01 CA069446-14 || CA</award-id>
</award-group>
<award-group><funding-source country="United States">National Cancer Institute  : NCI</funding-source>
<award-id>U01 CA069417-14 || CA</award-id>
</award-group>
<award-group><funding-source country="United States">National Cancer Institute  : NCI</funding-source>
<award-id>U01 CA069398-14 || CA</award-id>
</award-group>
<award-group><funding-source country="United States">National Cancer Institute  : NCI</funding-source>
<award-id>R01 CA128978-03 || CA</award-id>
</award-group>
<award-group><funding-source country="United States">National Cancer Institute  : NCI</funding-source>
<award-id>R01 CA122340-03 || CA</award-id>
</award-group>
<award-group><funding-source country="United States">National Cancer Institute  : NCI</funding-source>
<award-id>R01 CA074415-10 || CA</award-id>
</award-group>
<award-group><funding-source country="United States">National Cancer Institute  : NCI</funding-source>
<award-id>P50 CA116201-05 || CA</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
</record>

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A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population

A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population

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