Distinct Campylobacter fetus lineages adapted as livestock pathogens and human pathobionts in the intestinal microbiota
Identifieur interne : 000C52 ( Pmc/Curation ); précédent : 000C51; suivant : 000C53Distinct Campylobacter fetus lineages adapted as livestock pathogens and human pathobionts in the intestinal microbiota
Auteurs : Gregorio Iraola [Uruguay, Royaume-Uni] ; Samuel C. Forster [Royaume-Uni] ; Nitin Kumar [Royaume-Uni] ; Philippe Lehours [France] ; Sadjia Bekal ; Francisco J. García-Pe A [Espagne] ; Fernando Paolicchi [Argentine] ; Claudia Morsella [Argentine] ; Helmut Hotzel [Allemagne] ; Po-Ren Hsueh [Taïwan] ; Ana Vidal ; Simon Lévesque ; Wataru Yamazaki [Japon] ; Claudia Balzan [Brésil] ; Agueda Vargas [Brésil] ; Alessandra Piccirillo [Italie] ; Bonnie Chaban ; Janet E. Hill ; Laura Betancor [Uruguay] ; Luis Collado [Chili] ; Isabelle Truyers ; Anne C. Midwinter [Nouvelle-Zélande] ; Hatice T. Dagi [Turquie] ; Francis Mégraud [France] ; Lucía Calleros [Uruguay] ; Ruben Pérez [Uruguay] ; Hugo Naya [Uruguay] ; Trevor D. Lawley [Royaume-Uni]Source :
- Nature Communications [ 2041-1723 ] ; 2017.
Abstract
Url:
DOI: 10.1038/s41467-017-01449-9
PubMed: 29118316
PubMed Central: 5678084
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<institution>EpiLab, Infectious Disease Research Centre,</institution>
<institution>Massey University,</institution>
</institution-wrap>
Palmerston North, 4442 New Zealand</nlm:aff>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>Palmerston North</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dagi, Hatice T" sort="Dagi, Hatice T" uniqKey="Dagi H" first="Hatice T." last="Dagi">Hatice T. Dagi</name>
<affiliation wicri:level="1"><nlm:aff id="Aff24"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2308 7215</institution-id>
<institution-id institution-id-type="GRID">grid.17242.32</institution-id>
<institution>Department of Microbiology,</institution>
<institution>Faculty of Medicine, Selçuk University,</institution>
</institution-wrap>
Selçuklu, 42250 Turkey</nlm:aff>
<country xml:lang="fr">Turquie</country>
<wicri:regionArea>Selçuklu</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Megraud, Francis" sort="Megraud, Francis" uniqKey="Megraud F" first="Francis" last="Mégraud">Francis Mégraud</name>
<affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2106 639X</institution-id>
<institution-id institution-id-type="GRID">grid.412041.2</institution-id>
<institution>Bordeaux Research in Translational Oncology,</institution>
<institution>INSERM UMR1053, University of Bordeaux,</institution>
</institution-wrap>
33076 Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>33076 Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2106 639X</institution-id>
<institution-id institution-id-type="GRID">grid.412041.2</institution-id>
<institution>French National Reference Center for Campylobacters and Helicobacters,</institution>
<institution>University of Bordeaux,</institution>
</institution-wrap>
33076 Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>33076 Bordeaux</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Calleros, Lucia" sort="Calleros, Lucia" uniqKey="Calleros L" first="Lucía" last="Calleros">Lucía Calleros</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000000121657640</institution-id>
<institution-id institution-id-type="GRID">grid.11630.35</institution-id>
<institution>Sección Genética Evolutiva,</institution>
<institution>Facultad de Ciencias, Universidad de la República,</institution>
</institution-wrap>
11400 Montevideo, Uruguay</nlm:aff>
<country xml:lang="fr">Uruguay</country>
<wicri:regionArea>11400 Montevideo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Perez, Ruben" sort="Perez, Ruben" uniqKey="Perez R" first="Ruben" last="Pérez">Ruben Pérez</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000000121657640</institution-id>
<institution-id institution-id-type="GRID">grid.11630.35</institution-id>
<institution>Sección Genética Evolutiva,</institution>
<institution>Facultad de Ciencias, Universidad de la República,</institution>
</institution-wrap>
11400 Montevideo, Uruguay</nlm:aff>
<country xml:lang="fr">Uruguay</country>
<wicri:regionArea>11400 Montevideo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Naya, Hugo" sort="Naya, Hugo" uniqKey="Naya H" first="Hugo" last="Naya">Hugo Naya</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.418532.9</institution-id>
<institution>Unidad de Bioinformática,</institution>
<institution>Institut Pasteur Montevideo,</institution>
</institution-wrap>
11400 Montevideo, Uruguay</nlm:aff>
<country xml:lang="fr">Uruguay</country>
<wicri:regionArea>11400 Montevideo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff25"><institution-wrap><institution-id institution-id-type="ISNI">0000000121657640</institution-id>
<institution-id institution-id-type="GRID">grid.11630.35</institution-id>
<institution>Departamento de Producción Animal y Pasturas,</institution>
<institution>Facultad de Agronomía, Universidad de la República,</institution>
</institution-wrap>
12900 Montevideo, Uruguay</nlm:aff>
<country xml:lang="fr">Uruguay</country>
<wicri:regionArea>12900 Montevideo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lawley, Trevor D" sort="Lawley, Trevor D" uniqKey="Lawley T" first="Trevor D." last="Lawley">Trevor D. Lawley</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0606 5382</institution-id>
<institution-id institution-id-type="GRID">grid.10306.34</institution-id>
<institution>Host-Microbiota Interactions Laboratory,</institution>
<institution>Wellcome Trust Sanger Institute,</institution>
</institution-wrap>
CB10 1SA Hinxton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>CB10 1SA Hinxton</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">29118316</idno>
<idno type="pmc">5678084</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678084</idno>
<idno type="RBID">PMC:5678084</idno>
<idno type="doi">10.1038/s41467-017-01449-9</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Distinct <italic>Campylobacter fetus</italic>
lineages adapted as livestock pathogens and human pathobionts in the intestinal microbiota</title>
<author><name sortKey="Iraola, Gregorio" sort="Iraola, Gregorio" uniqKey="Iraola G" first="Gregorio" last="Iraola">Gregorio Iraola</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.418532.9</institution-id>
<institution>Unidad de Bioinformática,</institution>
<institution>Institut Pasteur Montevideo,</institution>
</institution-wrap>
11400 Montevideo, Uruguay</nlm:aff>
<country xml:lang="fr">Uruguay</country>
<wicri:regionArea>11400 Montevideo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000000121657640</institution-id>
<institution-id institution-id-type="GRID">grid.11630.35</institution-id>
<institution>Sección Genética Evolutiva,</institution>
<institution>Facultad de Ciencias, Universidad de la República,</institution>
</institution-wrap>
11400 Montevideo, Uruguay</nlm:aff>
<country xml:lang="fr">Uruguay</country>
<wicri:regionArea>11400 Montevideo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0606 5382</institution-id>
<institution-id institution-id-type="GRID">grid.10306.34</institution-id>
<institution>Host-Microbiota Interactions Laboratory,</institution>
<institution>Wellcome Trust Sanger Institute,</institution>
</institution-wrap>
CB10 1SA Hinxton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>CB10 1SA Hinxton</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Forster, Samuel C" sort="Forster, Samuel C" uniqKey="Forster S" first="Samuel C." last="Forster">Samuel C. Forster</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0606 5382</institution-id>
<institution-id institution-id-type="GRID">grid.10306.34</institution-id>
<institution>Host-Microbiota Interactions Laboratory,</institution>
<institution>Wellcome Trust Sanger Institute,</institution>
</institution-wrap>
CB10 1SA Hinxton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>CB10 1SA Hinxton</wicri:regionArea>
</affiliation>
<affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.452824.d</institution-id>
<institution>Centre for Innate Immunity and Infectious Diseases,</institution>
<institution>Hudson Institute of Medical Research,</institution>
</institution-wrap>
Clayton, VIC 3168 Australia</nlm:aff>
<wicri:noCountry code="subfield">VIC 3168 Australia</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7857</institution-id>
<institution-id institution-id-type="GRID">grid.1002.3</institution-id>
<institution>Department of Molecular and Translational Sciences,</institution>
<institution>Monash University,</institution>
</institution-wrap>
Clayton, VIC 3168 Australia</nlm:aff>
<wicri:noCountry code="subfield">VIC 3168 Australia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kumar, Nitin" sort="Kumar, Nitin" uniqKey="Kumar N" first="Nitin" last="Kumar">Nitin Kumar</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0606 5382</institution-id>
<institution-id institution-id-type="GRID">grid.10306.34</institution-id>
<institution>Host-Microbiota Interactions Laboratory,</institution>
<institution>Wellcome Trust Sanger Institute,</institution>
</institution-wrap>
CB10 1SA Hinxton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>CB10 1SA Hinxton</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lehours, Philippe" sort="Lehours, Philippe" uniqKey="Lehours P" first="Philippe" last="Lehours">Philippe Lehours</name>
<affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2106 639X</institution-id>
<institution-id institution-id-type="GRID">grid.412041.2</institution-id>
<institution>Bordeaux Research in Translational Oncology,</institution>
<institution>INSERM UMR1053, University of Bordeaux,</institution>
</institution-wrap>
33076 Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>33076 Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2106 639X</institution-id>
<institution-id institution-id-type="GRID">grid.412041.2</institution-id>
<institution>French National Reference Center for Campylobacters and Helicobacters,</institution>
<institution>University of Bordeaux,</institution>
</institution-wrap>
33076 Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>33076 Bordeaux</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bekal, Sadjia" sort="Bekal, Sadjia" uniqKey="Bekal S" first="Sadjia" last="Bekal">Sadjia Bekal</name>
<affiliation><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8929 2775</institution-id>
<institution-id institution-id-type="GRID">grid.434819.3</institution-id>
<institution>Laboratoire de Santé Publique du Québec,</institution>
<institution>Institut National de Santé Publique du Québec,</institution>
</institution-wrap>
Sainte-Anne-de-Bellevue, QC Canada H9X 3Y3</nlm:aff>
<wicri:noCountry code="subfield">QC Canada H9X 3Y3</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff9"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2292 3357</institution-id>
<institution-id institution-id-type="GRID">grid.14848.31</institution-id>
<institution>Départment de Microbiologie,</institution>
<institution>Immunologie et Infectiologie, Université de Montréal,</institution>
</institution-wrap>
Montreal, QC Canada H3T 1J4</nlm:aff>
<wicri:noCountry code="subfield">QC Canada H3T 1J4</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Garcia Pe A, Francisco J" sort="Garcia Pe A, Francisco J" uniqKey="Garcia Pe A F" first="Francisco J." last="García-Pe A">Francisco J. García-Pe A</name>
<affiliation wicri:level="1"><nlm:aff id="Aff10">Departamento de Bacteriología, Laboratorio Central de Veterinaria de Algete (MAGRAMA), 28110 Algete, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Departamento de Bacteriología, Laboratorio Central de Veterinaria de Algete (MAGRAMA), 28110 Algete</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Paolicchi, Fernando" sort="Paolicchi, Fernando" uniqKey="Paolicchi F" first="Fernando" last="Paolicchi">Fernando Paolicchi</name>
<affiliation wicri:level="1"><nlm:aff id="Aff11">Laboratorio de Bacteriología, EEA-INTA Balcarce, Balcarce, 7620 Argentina</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea>Laboratorio de Bacteriología, EEA-INTA Balcarce, Balcarce</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Morsella, Claudia" sort="Morsella, Claudia" uniqKey="Morsella C" first="Claudia" last="Morsella">Claudia Morsella</name>
<affiliation wicri:level="1"><nlm:aff id="Aff11">Laboratorio de Bacteriología, EEA-INTA Balcarce, Balcarce, 7620 Argentina</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea>Laboratorio de Bacteriología, EEA-INTA Balcarce, Balcarce</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hotzel, Helmut" sort="Hotzel, Helmut" uniqKey="Hotzel H" first="Helmut" last="Hotzel">Helmut Hotzel</name>
<affiliation wicri:level="1"><nlm:aff id="Aff12">Friedrich-Loeffler-Institut, Institute of Bacterial Infections and Zoonoses, 07743 Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Friedrich-Loeffler-Institut, Institute of Bacterial Infections and Zoonoses, 07743 Jena</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hsueh, Po Ren" sort="Hsueh, Po Ren" uniqKey="Hsueh P" first="Po-Ren" last="Hsueh">Po-Ren Hsueh</name>
<affiliation wicri:level="1"><nlm:aff id="Aff13"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0572 7815</institution-id>
<institution-id institution-id-type="GRID">grid.412094.a</institution-id>
<institution>Departments of Laboratory Medicine and Internal Medicine,</institution>
<institution>National Taiwan University Hospital,</institution>
</institution-wrap>
Taipei, 10617 Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Taipei</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vidal, Ana" sort="Vidal, Ana" uniqKey="Vidal A" first="Ana" last="Vidal">Ana Vidal</name>
<affiliation><nlm:aff id="Aff14"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1765 422X</institution-id>
<institution-id institution-id-type="GRID">grid.422685.f</institution-id>
<institution>Animal and Plant Health Association (APHA),</institution>
</institution-wrap>
Addlestone, KT15 3NB UK</nlm:aff>
<wicri:noCountry code="subfield">KT15 3NB UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Levesque, Simon" sort="Levesque, Simon" uniqKey="Levesque S" first="Simon" last="Lévesque">Simon Lévesque</name>
<affiliation><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8929 2775</institution-id>
<institution-id institution-id-type="GRID">grid.434819.3</institution-id>
<institution>Laboratoire de Santé Publique du Québec,</institution>
<institution>Institut National de Santé Publique du Québec,</institution>
</institution-wrap>
Sainte-Anne-de-Bellevue, QC Canada H9X 3Y3</nlm:aff>
<wicri:noCountry code="subfield">QC Canada H9X 3Y3</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Yamazaki, Wataru" sort="Yamazaki, Wataru" uniqKey="Yamazaki W" first="Wataru" last="Yamazaki">Wataru Yamazaki</name>
<affiliation wicri:level="1"><nlm:aff id="Aff15"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0657 3887</institution-id>
<institution-id institution-id-type="GRID">grid.410849.0</institution-id>
<institution>Department of Veterinary Science,</institution>
<institution>Faculty of Agriculture, University of Miyazaki,</institution>
</institution-wrap>
Miyazaki, 889-2192 Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Miyazaki</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Balzan, Claudia" sort="Balzan, Claudia" uniqKey="Balzan C" first="Claudia" last="Balzan">Claudia Balzan</name>
<affiliation wicri:level="1"><nlm:aff id="Aff16"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2284 6531</institution-id>
<institution-id institution-id-type="GRID">grid.411239.c</institution-id>
<institution>Departamento de Medicina Veterinária Preventiva,</institution>
<institution>Universidade Federal de Santa Maria,</institution>
</institution-wrap>
Santa Maria, 97105-900 Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Santa Maria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vargas, Agueda" sort="Vargas, Agueda" uniqKey="Vargas A" first="Agueda" last="Vargas">Agueda Vargas</name>
<affiliation wicri:level="1"><nlm:aff id="Aff16"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2284 6531</institution-id>
<institution-id institution-id-type="GRID">grid.411239.c</institution-id>
<institution>Departamento de Medicina Veterinária Preventiva,</institution>
<institution>Universidade Federal de Santa Maria,</institution>
</institution-wrap>
Santa Maria, 97105-900 Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Santa Maria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Piccirillo, Alessandra" sort="Piccirillo, Alessandra" uniqKey="Piccirillo A" first="Alessandra" last="Piccirillo">Alessandra Piccirillo</name>
<affiliation wicri:level="1"><nlm:aff id="Aff17"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1757 3470</institution-id>
<institution-id institution-id-type="GRID">grid.5608.b</institution-id>
<institution>Department of Comparative Biomedicine and Food Science,</institution>
<institution>University of Padova,</institution>
</institution-wrap>
Padova, 35122 Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Padova</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chaban, Bonnie" sort="Chaban, Bonnie" uniqKey="Chaban B" first="Bonnie" last="Chaban">Bonnie Chaban</name>
<affiliation><nlm:aff id="Aff18"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1555 3415</institution-id>
<institution-id institution-id-type="GRID">grid.1034.6</institution-id>
<institution>Faculty of Science,</institution>
<institution>Health, Education and Engineering, University of the Sunshine Coast,</institution>
</institution-wrap>
Sippy Downs, QLD 4556 Australia</nlm:aff>
<wicri:noCountry code="subfield">QLD 4556 Australia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Hill, Janet E" sort="Hill, Janet E" uniqKey="Hill J" first="Janet E." last="Hill">Janet E. Hill</name>
<affiliation><nlm:aff id="Aff19"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2154 235X</institution-id>
<institution-id institution-id-type="GRID">grid.25152.31</institution-id>
<institution>Department of Veterinary Microbiology,</institution>
<institution>University of Saskatchewan,</institution>
</institution-wrap>
Saskatchewan, SK Canada S7N 5A2</nlm:aff>
<wicri:noCountry code="subfield">SK Canada S7N 5A2</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Betancor, Laura" sort="Betancor, Laura" uniqKey="Betancor L" first="Laura" last="Betancor">Laura Betancor</name>
<affiliation wicri:level="1"><nlm:aff id="Aff20"><institution-wrap><institution-id institution-id-type="ISNI">0000000121657640</institution-id>
<institution-id institution-id-type="GRID">grid.11630.35</institution-id>
<institution>Instituto de Higiene,</institution>
<institution>Facultad de Medicina, Universidad de la República,</institution>
</institution-wrap>
Montevideo, 11600 Uruguay</nlm:aff>
<country xml:lang="fr">Uruguay</country>
<wicri:regionArea>Montevideo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Collado, Luis" sort="Collado, Luis" uniqKey="Collado L" first="Luis" last="Collado">Luis Collado</name>
<affiliation wicri:level="1"><nlm:aff id="Aff21"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0487 459X</institution-id>
<institution-id institution-id-type="GRID">grid.7119.e</institution-id>
<institution>Instituto de Bioquímica y Microbiología,</institution>
<institution>Facultad de Ciencias, Universidad Austral de Chile,</institution>
</institution-wrap>
5090000 Valdivia, Chile</nlm:aff>
<country xml:lang="fr">Chili</country>
<wicri:regionArea>5090000 Valdivia</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Truyers, Isabelle" sort="Truyers, Isabelle" uniqKey="Truyers I" first="Isabelle" last="Truyers">Isabelle Truyers</name>
<affiliation><nlm:aff id="Aff22"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7988</institution-id>
<institution-id institution-id-type="GRID">grid.4305.2</institution-id>
<institution>Royal (Dick) School of Veterinary Studies,</institution>
<institution>University of Edinburgh,</institution>
</institution-wrap>
Midlothian, EH25 9RG UK</nlm:aff>
<wicri:noCountry code="subfield">EH25 9RG UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Midwinter, Anne C" sort="Midwinter, Anne C" uniqKey="Midwinter A" first="Anne C." last="Midwinter">Anne C. Midwinter</name>
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<institution>EpiLab, Infectious Disease Research Centre,</institution>
<institution>Massey University,</institution>
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Palmerston North, 4442 New Zealand</nlm:aff>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>Palmerston North</wicri:regionArea>
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<institution>Faculty of Medicine, Selçuk University,</institution>
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Selçuklu, 42250 Turkey</nlm:aff>
<country xml:lang="fr">Turquie</country>
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<author><name sortKey="Megraud, Francis" sort="Megraud, Francis" uniqKey="Megraud F" first="Francis" last="Mégraud">Francis Mégraud</name>
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33076 Bordeaux, France</nlm:aff>
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33076 Bordeaux, France</nlm:aff>
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<author><name sortKey="Calleros, Lucia" sort="Calleros, Lucia" uniqKey="Calleros L" first="Lucía" last="Calleros">Lucía Calleros</name>
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<institution-id institution-id-type="GRID">grid.11630.35</institution-id>
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<institution>Facultad de Ciencias, Universidad de la República,</institution>
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11400 Montevideo, Uruguay</nlm:aff>
<country xml:lang="fr">Uruguay</country>
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<author><name sortKey="Perez, Ruben" sort="Perez, Ruben" uniqKey="Perez R" first="Ruben" last="Pérez">Ruben Pérez</name>
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<institution-id institution-id-type="GRID">grid.11630.35</institution-id>
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<institution>Facultad de Ciencias, Universidad de la República,</institution>
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11400 Montevideo, Uruguay</nlm:aff>
<country xml:lang="fr">Uruguay</country>
<wicri:regionArea>11400 Montevideo</wicri:regionArea>
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<institution>Unidad de Bioinformática,</institution>
<institution>Institut Pasteur Montevideo,</institution>
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11400 Montevideo, Uruguay</nlm:aff>
<country xml:lang="fr">Uruguay</country>
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<institution>Departamento de Producción Animal y Pasturas,</institution>
<institution>Facultad de Agronomía, Universidad de la República,</institution>
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12900 Montevideo, Uruguay</nlm:aff>
<country xml:lang="fr">Uruguay</country>
<wicri:regionArea>12900 Montevideo</wicri:regionArea>
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<author><name sortKey="Lawley, Trevor D" sort="Lawley, Trevor D" uniqKey="Lawley T" first="Trevor D." last="Lawley">Trevor D. Lawley</name>
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<institution-id institution-id-type="GRID">grid.10306.34</institution-id>
<institution>Host-Microbiota Interactions Laboratory,</institution>
<institution>Wellcome Trust Sanger Institute,</institution>
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CB10 1SA Hinxton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
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</analytic>
<series><title level="j">Nature Communications</title>
<idno type="eISSN">2041-1723</idno>
<imprint><date when="2017">2017</date>
</imprint>
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<front><div type="abstract" xml:lang="en"><p id="Par1"><italic>Campylobacter fetus</italic>
is a venereal pathogen of cattle and sheep, and an opportunistic human pathogen. It is often assumed that <italic>C. fetus</italic>
infection occurs in humans as a zoonosis through food chain transmission. Here we show that mammalian <italic>C. fetus</italic>
consists of distinct evolutionary lineages, primarily associated with either human or bovine hosts. We use whole-genome phylogenetics on 182 strains from 17 countries to provide evidence that <italic>C. fetus</italic>
may have originated in humans around 10,500 years ago and may have “jumped” into cattle during the livestock domestication period. We detect <italic>C. fetus</italic>
genomes in 8% of healthy human fecal metagenomes, where the human-associated lineages are the dominant type (78%). Thus, our work suggests that <italic>C. fetus</italic>
is an unappreciated human intestinal pathobiont likely spread by human to human transmission. This genome-based evolutionary framework will facilitate <italic>C. fetus</italic>
epidemiology research and the development of improved molecular diagnostics and prevention schemes for this neglected pathogen.</p>
</div>
</front>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Nat Commun</journal-id>
<journal-id journal-id-type="iso-abbrev">Nat Commun</journal-id>
<journal-title-group><journal-title>Nature Communications</journal-title>
</journal-title-group>
<issn pub-type="epub">2041-1723</issn>
<publisher><publisher-name>Nature Publishing Group UK</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">29118316</article-id>
<article-id pub-id-type="pmc">5678084</article-id>
<article-id pub-id-type="publisher-id">1449</article-id>
<article-id pub-id-type="doi">10.1038/s41467-017-01449-9</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Distinct <italic>Campylobacter fetus</italic>
lineages adapted as livestock pathogens and human pathobionts in the intestinal microbiota</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-6516-3404</contrib-id>
<name><surname>Iraola</surname>
<given-names>Gregorio</given-names>
</name>
<address><email>giraola@pasteur.edu.uy</email>
</address>
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</contrib>
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<given-names>Lucía</given-names>
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<given-names>Ruben</given-names>
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<address><email>tl2@sanger.ac.uk</email>
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</contrib>
<aff id="Aff1"><label>1</label>
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<institution>Unidad de Bioinformática,</institution>
<institution>Institut Pasteur Montevideo,</institution>
</institution-wrap>
11400 Montevideo, Uruguay</aff>
<aff id="Aff2"><label>2</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000000121657640</institution-id>
<institution-id institution-id-type="GRID">grid.11630.35</institution-id>
<institution>Sección Genética Evolutiva,</institution>
<institution>Facultad de Ciencias, Universidad de la República,</institution>
</institution-wrap>
11400 Montevideo, Uruguay</aff>
<aff id="Aff3"><label>3</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0606 5382</institution-id>
<institution-id institution-id-type="GRID">grid.10306.34</institution-id>
<institution>Host-Microbiota Interactions Laboratory,</institution>
<institution>Wellcome Trust Sanger Institute,</institution>
</institution-wrap>
CB10 1SA Hinxton, UK</aff>
<aff id="Aff4"><label>4</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.452824.d</institution-id>
<institution>Centre for Innate Immunity and Infectious Diseases,</institution>
<institution>Hudson Institute of Medical Research,</institution>
</institution-wrap>
Clayton, VIC 3168 Australia</aff>
<aff id="Aff5"><label>5</label>
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<institution-id institution-id-type="GRID">grid.1002.3</institution-id>
<institution>Department of Molecular and Translational Sciences,</institution>
<institution>Monash University,</institution>
</institution-wrap>
Clayton, VIC 3168 Australia</aff>
<aff id="Aff6"><label>6</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2106 639X</institution-id>
<institution-id institution-id-type="GRID">grid.412041.2</institution-id>
<institution>Bordeaux Research in Translational Oncology,</institution>
<institution>INSERM UMR1053, University of Bordeaux,</institution>
</institution-wrap>
33076 Bordeaux, France</aff>
<aff id="Aff7"><label>7</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2106 639X</institution-id>
<institution-id institution-id-type="GRID">grid.412041.2</institution-id>
<institution>French National Reference Center for Campylobacters and Helicobacters,</institution>
<institution>University of Bordeaux,</institution>
</institution-wrap>
33076 Bordeaux, France</aff>
<aff id="Aff8"><label>8</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8929 2775</institution-id>
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<institution>Laboratoire de Santé Publique du Québec,</institution>
<institution>Institut National de Santé Publique du Québec,</institution>
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Sainte-Anne-de-Bellevue, QC Canada H9X 3Y3</aff>
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<institution-id institution-id-type="GRID">grid.14848.31</institution-id>
<institution>Départment de Microbiologie,</institution>
<institution>Immunologie et Infectiologie, Université de Montréal,</institution>
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Montreal, QC Canada H3T 1J4</aff>
<aff id="Aff10"><label>10</label>
Departamento de Bacteriología, Laboratorio Central de Veterinaria de Algete (MAGRAMA), 28110 Algete, Spain</aff>
<aff id="Aff11"><label>11</label>
Laboratorio de Bacteriología, EEA-INTA Balcarce, Balcarce, 7620 Argentina</aff>
<aff id="Aff12"><label>12</label>
Friedrich-Loeffler-Institut, Institute of Bacterial Infections and Zoonoses, 07743 Jena, Germany</aff>
<aff id="Aff13"><label>13</label>
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<institution-id institution-id-type="GRID">grid.412094.a</institution-id>
<institution>Departments of Laboratory Medicine and Internal Medicine,</institution>
<institution>National Taiwan University Hospital,</institution>
</institution-wrap>
Taipei, 10617 Taiwan</aff>
<aff id="Aff14"><label>14</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1765 422X</institution-id>
<institution-id institution-id-type="GRID">grid.422685.f</institution-id>
<institution>Animal and Plant Health Association (APHA),</institution>
</institution-wrap>
Addlestone, KT15 3NB UK</aff>
<aff id="Aff15"><label>15</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0657 3887</institution-id>
<institution-id institution-id-type="GRID">grid.410849.0</institution-id>
<institution>Department of Veterinary Science,</institution>
<institution>Faculty of Agriculture, University of Miyazaki,</institution>
</institution-wrap>
Miyazaki, 889-2192 Japan</aff>
<aff id="Aff16"><label>16</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2284 6531</institution-id>
<institution-id institution-id-type="GRID">grid.411239.c</institution-id>
<institution>Departamento de Medicina Veterinária Preventiva,</institution>
<institution>Universidade Federal de Santa Maria,</institution>
</institution-wrap>
Santa Maria, 97105-900 Brazil</aff>
<aff id="Aff17"><label>17</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1757 3470</institution-id>
<institution-id institution-id-type="GRID">grid.5608.b</institution-id>
<institution>Department of Comparative Biomedicine and Food Science,</institution>
<institution>University of Padova,</institution>
</institution-wrap>
Padova, 35122 Italy</aff>
<aff id="Aff18"><label>18</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1555 3415</institution-id>
<institution-id institution-id-type="GRID">grid.1034.6</institution-id>
<institution>Faculty of Science,</institution>
<institution>Health, Education and Engineering, University of the Sunshine Coast,</institution>
</institution-wrap>
Sippy Downs, QLD 4556 Australia</aff>
<aff id="Aff19"><label>19</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2154 235X</institution-id>
<institution-id institution-id-type="GRID">grid.25152.31</institution-id>
<institution>Department of Veterinary Microbiology,</institution>
<institution>University of Saskatchewan,</institution>
</institution-wrap>
Saskatchewan, SK Canada S7N 5A2</aff>
<aff id="Aff20"><label>20</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000000121657640</institution-id>
<institution-id institution-id-type="GRID">grid.11630.35</institution-id>
<institution>Instituto de Higiene,</institution>
<institution>Facultad de Medicina, Universidad de la República,</institution>
</institution-wrap>
Montevideo, 11600 Uruguay</aff>
<aff id="Aff21"><label>21</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0487 459X</institution-id>
<institution-id institution-id-type="GRID">grid.7119.e</institution-id>
<institution>Instituto de Bioquímica y Microbiología,</institution>
<institution>Facultad de Ciencias, Universidad Austral de Chile,</institution>
</institution-wrap>
5090000 Valdivia, Chile</aff>
<aff id="Aff22"><label>22</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7988</institution-id>
<institution-id institution-id-type="GRID">grid.4305.2</institution-id>
<institution>Royal (Dick) School of Veterinary Studies,</institution>
<institution>University of Edinburgh,</institution>
</institution-wrap>
Midlothian, EH25 9RG UK</aff>
<aff id="Aff23"><label>23</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.148374.d</institution-id>
<institution>EpiLab, Infectious Disease Research Centre,</institution>
<institution>Massey University,</institution>
</institution-wrap>
Palmerston North, 4442 New Zealand</aff>
<aff id="Aff24"><label>24</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2308 7215</institution-id>
<institution-id institution-id-type="GRID">grid.17242.32</institution-id>
<institution>Department of Microbiology,</institution>
<institution>Faculty of Medicine, Selçuk University,</institution>
</institution-wrap>
Selçuklu, 42250 Turkey</aff>
<aff id="Aff25"><label>25</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000000121657640</institution-id>
<institution-id institution-id-type="GRID">grid.11630.35</institution-id>
<institution>Departamento de Producción Animal y Pasturas,</institution>
<institution>Facultad de Agronomía, Universidad de la República,</institution>
</institution-wrap>
12900 Montevideo, Uruguay</aff>
</contrib-group>
<pub-date pub-type="epub"><day>8</day>
<month>11</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>8</day>
<month>11</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="collection"><year>2017</year>
</pub-date>
<volume>8</volume>
<elocation-id>1367</elocation-id>
<history><date date-type="received"><day>13</day>
<month>2</month>
<year>2017</year>
</date>
<date date-type="accepted"><day>15</day>
<month>9</month>
<year>2017</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s) 2017</copyright-statement>
<license license-type="OpenAccess"><license-p><bold>Open Access</bold>
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
.</license-p>
</license>
</permissions>
<abstract id="Abs1"><p id="Par1"><italic>Campylobacter fetus</italic>
is a venereal pathogen of cattle and sheep, and an opportunistic human pathogen. It is often assumed that <italic>C. fetus</italic>
infection occurs in humans as a zoonosis through food chain transmission. Here we show that mammalian <italic>C. fetus</italic>
consists of distinct evolutionary lineages, primarily associated with either human or bovine hosts. We use whole-genome phylogenetics on 182 strains from 17 countries to provide evidence that <italic>C. fetus</italic>
may have originated in humans around 10,500 years ago and may have “jumped” into cattle during the livestock domestication period. We detect <italic>C. fetus</italic>
genomes in 8% of healthy human fecal metagenomes, where the human-associated lineages are the dominant type (78%). Thus, our work suggests that <italic>C. fetus</italic>
is an unappreciated human intestinal pathobiont likely spread by human to human transmission. This genome-based evolutionary framework will facilitate <italic>C. fetus</italic>
epidemiology research and the development of improved molecular diagnostics and prevention schemes for this neglected pathogen.</p>
</abstract>
<abstract id="Abs2" abstract-type="web-summary"><p id="Par2">Human infections with <italic>Campylobacter fetus</italic>
are often assumed to be derived from livestock. Here, Iraola et al. provide evidence that healthy humans may act as carriers and dispersers, and <italic>C. fetus</italic>
may have originated in humans as an intestinal pathobiont and then adapted as a livestock pathogen.</p>
</abstract>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2017</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
</record>
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