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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma<xref ref-type="author-notes" rid="FN1">*</xref>
</title>
<author><name sortKey="Kempf, Werner" sort="Kempf, Werner" uniqKey="Kempf W" first="Werner" last="Kempf">Werner Kempf</name>
<affiliation><nlm:aff id="aff1">Department of Dermatology, University Hospital Zürich, Zürich, Switzerland;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Kempf and Pfaltz, Histological Diagnostics, Research Unit, Zürich, Switzerland;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pfaltz, Katrin" sort="Pfaltz, Katrin" uniqKey="Pfaltz K" first="Katrin" last="Pfaltz">Katrin Pfaltz</name>
<affiliation><nlm:aff id="aff2">Kempf and Pfaltz, Histological Diagnostics, Research Unit, Zürich, Switzerland;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vermeer, Maarten H" sort="Vermeer, Maarten H" uniqKey="Vermeer M" first="Maarten H." last="Vermeer">Maarten H. Vermeer</name>
<affiliation><nlm:aff id="aff3">Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cozzio, Antonio" sort="Cozzio, Antonio" uniqKey="Cozzio A" first="Antonio" last="Cozzio">Antonio Cozzio</name>
<affiliation><nlm:aff id="aff1">Department of Dermatology, University Hospital Zürich, Zürich, Switzerland;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ortiz Romero, Pablo L" sort="Ortiz Romero, Pablo L" uniqKey="Ortiz Romero P" first="Pablo L." last="Ortiz-Romero">Pablo L. Ortiz-Romero</name>
<affiliation><nlm:aff id="aff4">Department of Dermatology, Hospital 12 de Octubre, Madrid, Spain;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bagot, Martine" sort="Bagot, Martine" uniqKey="Bagot M" first="Martine" last="Bagot">Martine Bagot</name>
<affiliation><nlm:aff id="aff5">Department of Dermatology, Hôpital Saint Louis, Paris, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Olsen, Elise" sort="Olsen, Elise" uniqKey="Olsen E" first="Elise" last="Olsen">Elise Olsen</name>
<affiliation><nlm:aff id="aff6">Department of Medicine, Divisions of Dermatology and Oncology, Duke University Medical Center, Durham, NC;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kim, Youn H" sort="Kim, Youn H" uniqKey="Kim Y" first="Youn H." last="Kim">Youn H. Kim</name>
<affiliation><nlm:aff id="aff7">Department of Dermatology, Stanford Comprehensive Cancer Center, Stanford, CA;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dummer, Reinhard" sort="Dummer, Reinhard" uniqKey="Dummer R" first="Reinhard" last="Dummer">Reinhard Dummer</name>
<affiliation><nlm:aff id="aff1">Department of Dermatology, University Hospital Zürich, Zürich, Switzerland;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pimpinelli, Nicola" sort="Pimpinelli, Nicola" uniqKey="Pimpinelli N" first="Nicola" last="Pimpinelli">Nicola Pimpinelli</name>
<affiliation><nlm:aff id="aff8">Department of Dermatological Sciences, University of Florence, Florence, Italy;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Whittaker, Sean" sort="Whittaker, Sean" uniqKey="Whittaker S" first="Sean" last="Whittaker">Sean Whittaker</name>
<affiliation><nlm:aff id="aff9">Skin Tumour Unit, St Thomas' Hospital, London, United Kingdom;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hodak, Emmilia" sort="Hodak, Emmilia" uniqKey="Hodak E" first="Emmilia" last="Hodak">Emmilia Hodak</name>
<affiliation><nlm:aff id="aff10">Department of Dermatology, Tel Aviv University, Tel Aviv, Israel;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cerroni, Lorenzo" sort="Cerroni, Lorenzo" uniqKey="Cerroni L" first="Lorenzo" last="Cerroni">Lorenzo Cerroni</name>
<affiliation><nlm:aff id="aff11">Department of Dermatology, Medical University, Graz, Austria;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Berti, Emilio" sort="Berti, Emilio" uniqKey="Berti E" first="Emilio" last="Berti">Emilio Berti</name>
<affiliation><nlm:aff id="aff12">Department of Dermatology, University of Milano-Bicocca, Istituti di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore di Milano, Milano, Italy;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Horwitz, Steve" sort="Horwitz, Steve" uniqKey="Horwitz S" first="Steve" last="Horwitz">Steve Horwitz</name>
<affiliation><nlm:aff id="aff13">Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Prince, H Miles" sort="Prince, H Miles" uniqKey="Prince H" first="H. Miles" last="Prince">H. Miles Prince</name>
<affiliation><nlm:aff id="aff14">Peter MacCallum Cancer Centre, East Melbourne, Australia;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Guitart, Joan" sort="Guitart, Joan" uniqKey="Guitart J" first="Joan" last="Guitart">Joan Guitart</name>
<affiliation><nlm:aff id="aff15">Department of Dermatology, Northwestern University, Chicago, IL;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Estrach, Teresa" sort="Estrach, Teresa" uniqKey="Estrach T" first="Teresa" last="Estrach">Teresa Estrach</name>
<affiliation><nlm:aff id="aff16">Department of Dermatology, Hospital Clínico, University of Barcelona, Barcelona, Spain;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sanches, Jose A" sort="Sanches, Jose A" uniqKey="Sanches J" first="José A." last="Sanches">José A. Sanches</name>
<affiliation><nlm:aff id="aff17">Department of Dermatology, University of São Paulo, São Paulo, Brazil;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Duvic, Madeleine" sort="Duvic, Madeleine" uniqKey="Duvic M" first="Madeleine" last="Duvic">Madeleine Duvic</name>
<affiliation><nlm:aff id="aff18">Department of Dermatology, The University of Texas M. D. Anderson Cancer Center, Houston, TX;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ranki, Annamari" sort="Ranki, Annamari" uniqKey="Ranki A" first="Annamari" last="Ranki">Annamari Ranki</name>
<affiliation><nlm:aff id="aff19">Department of Dermatology and Venereal Diseases, Helsinki University Hospital, Helsinki, Finland;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dreno, Brigitte" sort="Dreno, Brigitte" uniqKey="Dreno B" first="Brigitte" last="Dreno">Brigitte Dreno</name>
<affiliation><nlm:aff id="aff20">Department of Dermatology, University Hospital Nantes, Nantes, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ostheeren Michaelis, Sonja" sort="Ostheeren Michaelis, Sonja" uniqKey="Ostheeren Michaelis S" first="Sonja" last="Ostheeren-Michaelis">Sonja Ostheeren-Michaelis</name>
<affiliation><nlm:aff id="aff2">Kempf and Pfaltz, Histological Diagnostics, Research Unit, Zürich, Switzerland;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Knobler, Robert" sort="Knobler, Robert" uniqKey="Knobler R" first="Robert" last="Knobler">Robert Knobler</name>
<affiliation><nlm:aff wicri:cut="; and" id="aff21">Department of Dermatology, University of Vienna Medical School, University of Vienna, Vienna, Austria</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wood, Gary" sort="Wood, Gary" uniqKey="Wood G" first="Gary" last="Wood">Gary Wood</name>
<affiliation><nlm:aff id="aff22">Department of Dermatology, University of Wisconsin, Madison, WI</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Willemze, Rein" sort="Willemze, Rein" uniqKey="Willemze R" first="Rein" last="Willemze">Rein Willemze</name>
<affiliation><nlm:aff id="aff3">Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands;</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">21841159</idno>
<idno type="pmc">3204726</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204726</idno>
<idno type="RBID">PMC:3204726</idno>
<idno type="doi">10.1182/blood-2011-05-351346</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">002E72</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E72</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma<xref ref-type="author-notes" rid="FN1">*</xref>
</title>
<author><name sortKey="Kempf, Werner" sort="Kempf, Werner" uniqKey="Kempf W" first="Werner" last="Kempf">Werner Kempf</name>
<affiliation><nlm:aff id="aff1">Department of Dermatology, University Hospital Zürich, Zürich, Switzerland;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Kempf and Pfaltz, Histological Diagnostics, Research Unit, Zürich, Switzerland;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pfaltz, Katrin" sort="Pfaltz, Katrin" uniqKey="Pfaltz K" first="Katrin" last="Pfaltz">Katrin Pfaltz</name>
<affiliation><nlm:aff id="aff2">Kempf and Pfaltz, Histological Diagnostics, Research Unit, Zürich, Switzerland;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vermeer, Maarten H" sort="Vermeer, Maarten H" uniqKey="Vermeer M" first="Maarten H." last="Vermeer">Maarten H. Vermeer</name>
<affiliation><nlm:aff id="aff3">Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cozzio, Antonio" sort="Cozzio, Antonio" uniqKey="Cozzio A" first="Antonio" last="Cozzio">Antonio Cozzio</name>
<affiliation><nlm:aff id="aff1">Department of Dermatology, University Hospital Zürich, Zürich, Switzerland;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ortiz Romero, Pablo L" sort="Ortiz Romero, Pablo L" uniqKey="Ortiz Romero P" first="Pablo L." last="Ortiz-Romero">Pablo L. Ortiz-Romero</name>
<affiliation><nlm:aff id="aff4">Department of Dermatology, Hospital 12 de Octubre, Madrid, Spain;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bagot, Martine" sort="Bagot, Martine" uniqKey="Bagot M" first="Martine" last="Bagot">Martine Bagot</name>
<affiliation><nlm:aff id="aff5">Department of Dermatology, Hôpital Saint Louis, Paris, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Olsen, Elise" sort="Olsen, Elise" uniqKey="Olsen E" first="Elise" last="Olsen">Elise Olsen</name>
<affiliation><nlm:aff id="aff6">Department of Medicine, Divisions of Dermatology and Oncology, Duke University Medical Center, Durham, NC;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kim, Youn H" sort="Kim, Youn H" uniqKey="Kim Y" first="Youn H." last="Kim">Youn H. Kim</name>
<affiliation><nlm:aff id="aff7">Department of Dermatology, Stanford Comprehensive Cancer Center, Stanford, CA;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dummer, Reinhard" sort="Dummer, Reinhard" uniqKey="Dummer R" first="Reinhard" last="Dummer">Reinhard Dummer</name>
<affiliation><nlm:aff id="aff1">Department of Dermatology, University Hospital Zürich, Zürich, Switzerland;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pimpinelli, Nicola" sort="Pimpinelli, Nicola" uniqKey="Pimpinelli N" first="Nicola" last="Pimpinelli">Nicola Pimpinelli</name>
<affiliation><nlm:aff id="aff8">Department of Dermatological Sciences, University of Florence, Florence, Italy;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Whittaker, Sean" sort="Whittaker, Sean" uniqKey="Whittaker S" first="Sean" last="Whittaker">Sean Whittaker</name>
<affiliation><nlm:aff id="aff9">Skin Tumour Unit, St Thomas' Hospital, London, United Kingdom;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hodak, Emmilia" sort="Hodak, Emmilia" uniqKey="Hodak E" first="Emmilia" last="Hodak">Emmilia Hodak</name>
<affiliation><nlm:aff id="aff10">Department of Dermatology, Tel Aviv University, Tel Aviv, Israel;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cerroni, Lorenzo" sort="Cerroni, Lorenzo" uniqKey="Cerroni L" first="Lorenzo" last="Cerroni">Lorenzo Cerroni</name>
<affiliation><nlm:aff id="aff11">Department of Dermatology, Medical University, Graz, Austria;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Berti, Emilio" sort="Berti, Emilio" uniqKey="Berti E" first="Emilio" last="Berti">Emilio Berti</name>
<affiliation><nlm:aff id="aff12">Department of Dermatology, University of Milano-Bicocca, Istituti di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore di Milano, Milano, Italy;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Horwitz, Steve" sort="Horwitz, Steve" uniqKey="Horwitz S" first="Steve" last="Horwitz">Steve Horwitz</name>
<affiliation><nlm:aff id="aff13">Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Prince, H Miles" sort="Prince, H Miles" uniqKey="Prince H" first="H. Miles" last="Prince">H. Miles Prince</name>
<affiliation><nlm:aff id="aff14">Peter MacCallum Cancer Centre, East Melbourne, Australia;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Guitart, Joan" sort="Guitart, Joan" uniqKey="Guitart J" first="Joan" last="Guitart">Joan Guitart</name>
<affiliation><nlm:aff id="aff15">Department of Dermatology, Northwestern University, Chicago, IL;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Estrach, Teresa" sort="Estrach, Teresa" uniqKey="Estrach T" first="Teresa" last="Estrach">Teresa Estrach</name>
<affiliation><nlm:aff id="aff16">Department of Dermatology, Hospital Clínico, University of Barcelona, Barcelona, Spain;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sanches, Jose A" sort="Sanches, Jose A" uniqKey="Sanches J" first="José A." last="Sanches">José A. Sanches</name>
<affiliation><nlm:aff id="aff17">Department of Dermatology, University of São Paulo, São Paulo, Brazil;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Duvic, Madeleine" sort="Duvic, Madeleine" uniqKey="Duvic M" first="Madeleine" last="Duvic">Madeleine Duvic</name>
<affiliation><nlm:aff id="aff18">Department of Dermatology, The University of Texas M. D. Anderson Cancer Center, Houston, TX;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ranki, Annamari" sort="Ranki, Annamari" uniqKey="Ranki A" first="Annamari" last="Ranki">Annamari Ranki</name>
<affiliation><nlm:aff id="aff19">Department of Dermatology and Venereal Diseases, Helsinki University Hospital, Helsinki, Finland;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dreno, Brigitte" sort="Dreno, Brigitte" uniqKey="Dreno B" first="Brigitte" last="Dreno">Brigitte Dreno</name>
<affiliation><nlm:aff id="aff20">Department of Dermatology, University Hospital Nantes, Nantes, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ostheeren Michaelis, Sonja" sort="Ostheeren Michaelis, Sonja" uniqKey="Ostheeren Michaelis S" first="Sonja" last="Ostheeren-Michaelis">Sonja Ostheeren-Michaelis</name>
<affiliation><nlm:aff id="aff2">Kempf and Pfaltz, Histological Diagnostics, Research Unit, Zürich, Switzerland;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Knobler, Robert" sort="Knobler, Robert" uniqKey="Knobler R" first="Robert" last="Knobler">Robert Knobler</name>
<affiliation><nlm:aff wicri:cut="; and" id="aff21">Department of Dermatology, University of Vienna Medical School, University of Vienna, Vienna, Austria</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wood, Gary" sort="Wood, Gary" uniqKey="Wood G" first="Gary" last="Wood">Gary Wood</name>
<affiliation><nlm:aff id="aff22">Department of Dermatology, University of Wisconsin, Madison, WI</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Willemze, Rein" sort="Willemze, Rein" uniqKey="Willemze R" first="Rein" last="Willemze">Rein Willemze</name>
<affiliation><nlm:aff id="aff3">Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands;</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Blood</title>
<idno type="ISSN">0006-4971</idno>
<idno type="eISSN">1528-0020</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Primary cutaneous CD30<sup>+</sup>
lymphoproliferative disorders (CD30<sup>+</sup>
LPDs) are the second most common form of cutaneous T-cell lymphomas and include lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. Despite the anaplastic cytomorphology of tumor cells that suggest an aggressive course, CD30<sup>+</sup>
LPDs are characterized by an excellent prognosis. Although a broad spectrum of therapeutic strategies has been reported, these have been limited mostly to small retrospective cohort series or case reports, and only very few prospective controlled or multicenter studies have been performed, which results in a low level of evidence for most therapies. The response rates to treatment, recurrence rates, and outcome have not been analyzed in a systematic review. Moreover, international guidelines for staging and treatment of CD30<sup>+</sup>
LPDs have not yet been presented. Based on a literature analysis and discussions, recommendations were elaborated by a multidisciplinary expert panel of the Cutaneous Lymphoma Task Force of the European Organization for Research and Treatment of Cancer, the International Society for Cutaneous Lymphomas, and the United States Cutaneous Lymphoma Consortium. The recommendations represent the state-of-the-art management of CD30<sup>+</sup>
LPDs and include definitions for clinical endpoints as well as response criteria for future clinical trials in CD30<sup>+</sup>
LPDs.</p>
</div>
</front>
</TEI>
<pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Blood</journal-id>
<journal-id journal-id-type="hwp">bloodjournal</journal-id>
<journal-id journal-id-type="pmc">blood</journal-id>
<journal-id journal-id-type="publisher-id">Blood</journal-id>
<journal-title-group><journal-title>Blood</journal-title>
</journal-title-group>
<issn pub-type="ppub">0006-4971</issn>
<issn pub-type="epub">1528-0020</issn>
<publisher><publisher-name>American Society of Hematology</publisher-name>
<publisher-loc>Washington, DC</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21841159</article-id>
<article-id pub-id-type="pmc">3204726</article-id>
<article-id pub-id-type="publisher-id">2011/351346</article-id>
<article-id pub-id-type="doi">10.1182/blood-2011-05-351346</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review Article</subject>
</subj-group>
<subj-group subj-group-type="heading"><subject>Lymphoid Neoplasia</subject>
</subj-group>
</article-categories>
<title-group><article-title>EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma<xref ref-type="author-notes" rid="FN1">*</xref>
</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Kempf</surname>
<given-names>Werner</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pfaltz</surname>
<given-names>Katrin</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
<xref ref-type="author-notes" rid="FN2">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vermeer</surname>
<given-names>Maarten H.</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
<xref ref-type="author-notes" rid="FN2">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cozzio</surname>
<given-names>Antonio</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ortiz-Romero</surname>
<given-names>Pablo L.</given-names>
</name>
<xref ref-type="aff" rid="aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bagot</surname>
<given-names>Martine</given-names>
</name>
<xref ref-type="aff" rid="aff5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Olsen</surname>
<given-names>Elise</given-names>
</name>
<xref ref-type="aff" rid="aff6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kim</surname>
<given-names>Youn H.</given-names>
</name>
<xref ref-type="aff" rid="aff7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dummer</surname>
<given-names>Reinhard</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pimpinelli</surname>
<given-names>Nicola</given-names>
</name>
<xref ref-type="aff" rid="aff8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Whittaker</surname>
<given-names>Sean</given-names>
</name>
<xref ref-type="aff" rid="aff9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hodak</surname>
<given-names>Emmilia</given-names>
</name>
<xref ref-type="aff" rid="aff10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cerroni</surname>
<given-names>Lorenzo</given-names>
</name>
<xref ref-type="aff" rid="aff11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Berti</surname>
<given-names>Emilio</given-names>
</name>
<xref ref-type="aff" rid="aff12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Horwitz</surname>
<given-names>Steve</given-names>
</name>
<xref ref-type="aff" rid="aff13">13</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Prince</surname>
<given-names>H. Miles</given-names>
</name>
<xref ref-type="aff" rid="aff14">14</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Guitart</surname>
<given-names>Joan</given-names>
</name>
<xref ref-type="aff" rid="aff15">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Estrach</surname>
<given-names>Teresa</given-names>
</name>
<xref ref-type="aff" rid="aff16">16</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sanches</surname>
<given-names>José A.</given-names>
</name>
<xref ref-type="aff" rid="aff17">17</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Duvic</surname>
<given-names>Madeleine</given-names>
</name>
<xref ref-type="aff" rid="aff18">18</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ranki</surname>
<given-names>Annamari</given-names>
</name>
<xref ref-type="aff" rid="aff19">19</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dreno</surname>
<given-names>Brigitte</given-names>
</name>
<xref ref-type="aff" rid="aff20">20</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ostheeren-Michaelis</surname>
<given-names>Sonja</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Knobler</surname>
<given-names>Robert</given-names>
</name>
<xref ref-type="aff" rid="aff21">21</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wood</surname>
<given-names>Gary</given-names>
</name>
<xref ref-type="aff" rid="aff22">22</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Willemze</surname>
<given-names>Rein</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<aff id="aff1"><label>1</label>
Department of Dermatology, University Hospital Zürich, Zürich, Switzerland;</aff>
<aff id="aff2"><label>2</label>
Kempf and Pfaltz, Histological Diagnostics, Research Unit, Zürich, Switzerland;</aff>
<aff id="aff3"><label>3</label>
Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands;</aff>
<aff id="aff4"><label>4</label>
Department of Dermatology, Hospital 12 de Octubre, Madrid, Spain;</aff>
<aff id="aff5"><label>5</label>
Department of Dermatology, Hôpital Saint Louis, Paris, France;</aff>
<aff id="aff6"><label>6</label>
Department of Medicine, Divisions of Dermatology and Oncology, Duke University Medical Center, Durham, NC;</aff>
<aff id="aff7"><label>7</label>
Department of Dermatology, Stanford Comprehensive Cancer Center, Stanford, CA;</aff>
<aff id="aff8"><label>8</label>
Department of Dermatological Sciences, University of Florence, Florence, Italy;</aff>
<aff id="aff9"><label>9</label>
Skin Tumour Unit, St Thomas' Hospital, London, United Kingdom;</aff>
<aff id="aff10"><label>10</label>
Department of Dermatology, Tel Aviv University, Tel Aviv, Israel;</aff>
<aff id="aff11"><label>11</label>
Department of Dermatology, Medical University, Graz, Austria;</aff>
<aff id="aff12"><label>12</label>
Department of Dermatology, University of Milano-Bicocca, Istituti di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore di Milano, Milano, Italy;</aff>
<aff id="aff13"><label>13</label>
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY;</aff>
<aff id="aff14"><label>14</label>
Peter MacCallum Cancer Centre, East Melbourne, Australia;</aff>
<aff id="aff15"><label>15</label>
Department of Dermatology, Northwestern University, Chicago, IL;</aff>
<aff id="aff16"><label>16</label>
Department of Dermatology, Hospital Clínico, University of Barcelona, Barcelona, Spain;</aff>
<aff id="aff17"><label>17</label>
Department of Dermatology, University of São Paulo, São Paulo, Brazil;</aff>
<aff id="aff18"><label>18</label>
Department of Dermatology, The University of Texas M. D. Anderson Cancer Center, Houston, TX;</aff>
<aff id="aff19"><label>19</label>
Department of Dermatology and Venereal Diseases, Helsinki University Hospital, Helsinki, Finland;</aff>
<aff id="aff20"><label>20</label>
Department of Dermatology, University Hospital Nantes, Nantes, France;</aff>
<aff id="aff21"><label>21</label>
Department of Dermatology, University of Vienna Medical School, University of Vienna, Vienna, Austria; and</aff>
<aff id="aff22"><label>22</label>
Department of Dermatology, University of Wisconsin, Madison, WI</aff>
</contrib-group>
<author-notes><fn fn-type="other" id="FN1"><label>*</label>
<p>The groups involved in the consensus recommendations are as follows: European Organization for Research and Treatment of Cancer (EORTC), International Society of Cutaneous Lymphoma (ISCL), and United States Cutaneous Lymphoma Consortium (USCLC).</p>
</fn>
<fn fn-type="equal" id="FN2"><label>†</label>
<p>K.P. and M.H.V. contributed equally to this study.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><day>13</day>
<month>10</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="epreprint"><day>12</day>
<month>8</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>13</day>
<month>10</month>
<year>2011</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
. </pmc-comment>
<volume>118</volume>
<issue>15</issue>
<fpage>4024</fpage>
<lpage>4035</lpage>
<history><date date-type="received"><day>22</day>
<month>5</month>
<year>2011</year>
</date>
<date date-type="accepted"><day>26</day>
<month>7</month>
<year>2011</year>
</date>
</history>
<permissions><copyright-statement>© 2011 by The American Society of Hematology</copyright-statement>
<copyright-year>2011</copyright-year>
</permissions>
<self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zh804111004024.pdf"></self-uri>
<abstract><p>Primary cutaneous CD30<sup>+</sup>
lymphoproliferative disorders (CD30<sup>+</sup>
LPDs) are the second most common form of cutaneous T-cell lymphomas and include lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. Despite the anaplastic cytomorphology of tumor cells that suggest an aggressive course, CD30<sup>+</sup>
LPDs are characterized by an excellent prognosis. Although a broad spectrum of therapeutic strategies has been reported, these have been limited mostly to small retrospective cohort series or case reports, and only very few prospective controlled or multicenter studies have been performed, which results in a low level of evidence for most therapies. The response rates to treatment, recurrence rates, and outcome have not been analyzed in a systematic review. Moreover, international guidelines for staging and treatment of CD30<sup>+</sup>
LPDs have not yet been presented. Based on a literature analysis and discussions, recommendations were elaborated by a multidisciplinary expert panel of the Cutaneous Lymphoma Task Force of the European Organization for Research and Treatment of Cancer, the International Society for Cutaneous Lymphomas, and the United States Cutaneous Lymphoma Consortium. The recommendations represent the state-of-the-art management of CD30<sup>+</sup>
LPDs and include definitions for clinical endpoints as well as response criteria for future clinical trials in CD30<sup>+</sup>
LPDs.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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