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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer</title><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation><nlm:aff id="A2">Department of Genetics, QIMR (Queensland Institute for Medical Research) Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindstrom">Sara Lindstrom</name><affiliation><nlm:aff id="A3">Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Canisius, Sander" sort="Canisius, Sander" uniqKey="Canisius S" first="Sander" last="Canisius">Sander Canisius</name><affiliation><nlm:aff id="A4">Division of Molecular Carcinogenesis, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Lush, Michael" sort="Lush, Michael" uniqKey="Lush M" first="Michael" last="Lush">Michael Lush</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Maranian, Mel J" sort="Maranian, Mel J" uniqKey="Maranian M" first="Mel J" last="Maranian">Mel J. Maranian</name><affiliation><nlm:aff id="A5">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K" last="Bolla">Manjeet K. Bolla</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name><affiliation><nlm:aff id="A5">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Perkins, Barbara J" sort="Perkins, Barbara J" uniqKey="Perkins B" first="Barbara J" last="Perkins">Barbara J. Perkins</name><affiliation><nlm:aff id="A5">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="A6">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Mikael" sort="Eriksson, Mikael" uniqKey="Eriksson M" first="Mikael" last="Eriksson">Mikael Eriksson</name><affiliation><nlm:aff id="A6">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name><affiliation><nlm:aff id="A6">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Brand, Judith S" sort="Brand, Judith S" uniqKey="Brand J" first="Judith S" last="Brand">Judith S. Brand</name><affiliation><nlm:aff id="A6">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E" last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="A7">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G" last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation><nlm:aff id="A7">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="A10">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nielsen, Sune F" sort="Nielsen, Sune F" uniqKey="Nielsen S" first="Sune F" last="Nielsen">Sune F. Nielsen</name><affiliation><nlm:aff id="A7">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><affiliation><nlm:aff id="A11">Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Turnbull, Clare" sort="Turnbull, Clare" uniqKey="Turnbull C" first="Clare" last="Turnbull">Clare Turnbull</name><affiliation><nlm:aff id="A11">Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="A12">Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="A13">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff></affiliation></author><author><name sortKey="Gibson, Lorna" sort="Gibson, Lorna" uniqKey="Gibson L" first="Lorna" last="Gibson">Lorna Gibson</name><affiliation><nlm:aff id="A13">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><affiliation><nlm:aff id="A13">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="A14">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="A15">Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Hamburg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="A14">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Eilber, Ursula" sort="Eilber, Ursula" uniqKey="Eilber U" first="Ursula" last="Eilber">Ursula Eilber</name><affiliation><nlm:aff id="A14">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Behrens, Sabine" sort="Behrens, Sabine" uniqKey="Behrens S" first="Sabine" last="Behrens">Sabine Behrens</name><affiliation><nlm:aff id="A14">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="A17">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A" last="Muranen">Taru A. Muranen</name><affiliation><nlm:aff id="A17">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="A18">Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation><nlm:aff id="A19">Department of Oncology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Khan, Sofia" sort="Khan, Sofia" uniqKey="Khan S" first="Sofia" last="Khan">Sofia Khan</name><affiliation><nlm:aff id="A17">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Aaltonen, Kirsimari" sort="Aaltonen, Kirsimari" uniqKey="Aaltonen K" first="Kirsimari" last="Aaltonen">Kirsimari Aaltonen</name><affiliation><nlm:aff id="A17">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Ahsan, Habibul" sort="Ahsan, Habibul" uniqKey="Ahsan H" first="Habibul" last="Ahsan">Habibul Ahsan</name><affiliation><nlm:aff id="A20">Center for Cancer Epidemiology and Prevention, University of Chicago, Chicago, Illinois</nlm:aff></affiliation><affiliation><nlm:aff id="A21">Department of Health Studies, University of Chicago, Chicago, Illinois</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Department of Medicine, University of Chicago, Chicago, Illinois</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Department of Human Genetics, University of Chicago, Chicago, Illinois</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Comprehensive Cancer Center, University of Chicago, Chicago, Illinois</nlm:aff></affiliation></author><author><name sortKey="Kibriya, Muhammad G" sort="Kibriya, Muhammad G" uniqKey="Kibriya M" first="Muhammad G" last="Kibriya">Muhammad G. Kibriya</name><affiliation><nlm:aff id="A20">Center for Cancer Epidemiology and Prevention, University of Chicago, Chicago, Illinois</nlm:aff></affiliation><affiliation><nlm:aff id="A21">Department of Health Studies, University of Chicago, Chicago, Illinois</nlm:aff></affiliation></author><author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S" last="Whittemore">Alice S. Whittemore</name><affiliation><nlm:aff id="A25">Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A26">Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M" last="John">Esther M. John</name><affiliation><nlm:aff id="A25">Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A26">Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Department of Epidemiology, Cancer Prevention Institute of California, Fremont, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Malone, Kathleen E" sort="Malone, Kathleen E" uniqKey="Malone K" first="Kathleen E" last="Malone">Kathleen E. Malone</name><affiliation><nlm:aff id="A28">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="Gammon, Marilie D" sort="Gammon, Marilie D" uniqKey="Gammon M" first="Marilie D" last="Gammon">Marilie D. Gammon</name><affiliation><nlm:aff id="A29">Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina</nlm:aff></affiliation></author><author><name sortKey="Santella, Regina M" sort="Santella, Regina M" uniqKey="Santella R" first="Regina M" last="Santella">Regina M. Santella</name><affiliation><nlm:aff id="A30">Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York</nlm:aff></affiliation></author><author><name sortKey="Ursin, Giske" sort="Ursin, Giske" uniqKey="Ursin G" first="Giske" last="Ursin">Giske Ursin</name><affiliation><nlm:aff id="A31">Norway Cancer Registry, Norway</nlm:aff></affiliation></author><author><name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name><affiliation><nlm:aff id="A32">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Daniel F" sort="Schmidt, Daniel F" uniqKey="Schmidt D" first="Daniel F" last="Schmidt">Daniel F. Schmidt</name><affiliation><nlm:aff id="A32">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><affiliation><nlm:aff id="A33">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name><affiliation><nlm:aff id="A3">Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Gapstur, Susan M" sort="Gapstur, Susan M" uniqKey="Gapstur S" first="Susan M" last="Gapstur">Susan M. Gapstur</name><affiliation><nlm:aff id="A34">Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M" last="Gaudet">Mia M. Gaudet</name><affiliation><nlm:aff id="A34">Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Diver, W Ryan" sort="Diver, W Ryan" uniqKey="Diver W" first="W Ryan" last="Diver">W Ryan Diver</name><affiliation><nlm:aff id="A34">Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A" last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="A33">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Schumacher, Fredrick" sort="Schumacher, Fredrick" uniqKey="Schumacher F" first="Fredrick" last="Schumacher">Fredrick Schumacher</name><affiliation><nlm:aff id="A33">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E" last="Henderson">Brian E. Henderson</name><affiliation><nlm:aff id="A33">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="A35">Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA</nlm:aff></affiliation></author><author><name sortKey="Berg, Christine D" sort="Berg, Christine D" uniqKey="Berg C" first="Christine D" last="Berg">Christine D. Berg</name><affiliation><nlm:aff id="A36">Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Medicine, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen" sort="Chanock, Stephen" uniqKey="Chanock S" first="Stephen" last="Chanock">Stephen Chanock</name><affiliation><nlm:aff id="A37">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name><affiliation><nlm:aff id="A37">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Hoover, Robert N" sort="Hoover, Robert N" uniqKey="Hoover R" first="Robert N" last="Hoover">Robert N. Hoover</name><affiliation><nlm:aff id="A37">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="A38">Vesalius Research Center, VIB, Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Neven, Patrick" sort="Neven, Patrick" uniqKey="Neven P" first="Patrick" last="Neven">Patrick Neven</name><affiliation><nlm:aff id="A40">Multidisciplinary Breast Center, University Hospitals Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Wildiers, Hans" sort="Wildiers, Hans" uniqKey="Wildiers H" first="Hans" last="Wildiers">Hans Wildiers</name><affiliation><nlm:aff id="A40">Multidisciplinary Breast Center, University Hospitals Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Van Limbergen, Erik" sort="Van Limbergen, Erik" uniqKey="Van Limbergen E" first="Erik" last="Van Limbergen">Erik Van Limbergen</name><affiliation><nlm:aff id="A40">Multidisciplinary Breast Center, University Hospitals Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K" last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="A41">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation><nlm:aff id="A41">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Verhoef, Senno" sort="Verhoef, Senno" uniqKey="Verhoef S" first="Senno" last="Verhoef">Senno Verhoef</name><affiliation><nlm:aff id="A41">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Cornelissen, Sten" sort="Cornelissen, Sten" uniqKey="Cornelissen S" first="Sten" last="Cornelissen">Sten Cornelissen</name><affiliation><nlm:aff id="A41">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J" last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="A42">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E" last="Olson">Janet E. Olson</name><affiliation><nlm:aff id="A43">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Hallberg, Emily" sort="Hallberg, Emily" uniqKey="Hallberg E" first="Emily" last="Hallberg">Emily Hallberg</name><affiliation><nlm:aff id="A43">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name><affiliation><nlm:aff id="A43">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Waisfisz, Quinten" sort="Waisfisz, Quinten" uniqKey="Waisfisz Q" first="Quinten" last="Waisfisz">Quinten Waisfisz</name><affiliation><nlm:aff id="A44">Department of Clinical Genetics, VU University Medical Center, section Oncogenetics, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Meijers Heijboer, Hanne" sort="Meijers Heijboer, Hanne" uniqKey="Meijers Heijboer H" first="Hanne" last="Meijers-Heijboer">Hanne Meijers-Heijboer</name><affiliation><nlm:aff id="A44">Department of Clinical Genetics, VU University Medical Center, section Oncogenetics, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Adank, Muriel A" sort="Adank, Muriel A" uniqKey="Adank M" first="Muriel A" last="Adank">Muriel A. Adank</name><affiliation><nlm:aff id="A44">Department of Clinical Genetics, VU University Medical Center, section Oncogenetics, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Der Luijt, Rob B" sort="Van Der Luijt, Rob B" uniqKey="Van Der Luijt R" first="Rob B" last="Van Der Luijt">Rob B. Van Der Luijt</name><affiliation><nlm:aff id="A45">Division of Biomedical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation><nlm:aff id="A6">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation><nlm:aff id="A46">Human Genetics Division, Genome Institute of Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name><affiliation><nlm:aff id="A6">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Kang, Daehee" sort="Kang, Daehee" uniqKey="Kang D" first="Daehee" last="Kang">Daehee Kang</name><affiliation><nlm:aff id="A47">Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A49">Cancer Research Institute, Seoul National University, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Choi, Ji Yeob" sort="Choi, Ji Yeob" uniqKey="Choi J" first="Ji-Yeob" last="Choi">Ji-Yeob Choi</name><affiliation><nlm:aff id="A48">Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A49">Cancer Research Institute, Seoul National University, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Park, Sue K" sort="Park, Sue K" uniqKey="Park S" first="Sue K" last="Park">Sue K. Park</name><affiliation><nlm:aff id="A47">Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A49">Cancer Research Institute, Seoul National University, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Yoo, Keun Young" sort="Yoo, Keun Young" uniqKey="Yoo K" first="Keun-Young" last="Yoo">Keun-Young Yoo</name><affiliation><nlm:aff id="A50">Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Matsuo, Keitaro" sort="Matsuo, Keitaro" uniqKey="Matsuo K" first="Keitaro" last="Matsuo">Keitaro Matsuo</name><affiliation><nlm:aff id="A51">Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan</nlm:aff></affiliation></author><author><name sortKey="Ito, Hidemi" sort="Ito, Hidemi" uniqKey="Ito H" first="Hidemi" last="Ito">Hidemi Ito</name><affiliation><nlm:aff id="A52">Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan</nlm:aff></affiliation></author><author><name sortKey="Iwata, Hiroji" sort="Iwata, Hiroji" uniqKey="Iwata H" first="Hiroji" last="Iwata">Hiroji Iwata</name><affiliation><nlm:aff id="A53">Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan</nlm:aff></affiliation></author><author><name sortKey="Tajima, Kazuo" sort="Tajima, Kazuo" uniqKey="Tajima K" first="Kazuo" last="Tajima">Kazuo Tajima</name><affiliation><nlm:aff id="A54">Epidemiology Center for Disease Control and Prevention, Mie University Hospital, Tsu, Mie, Japan</nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation><nlm:aff id="A55">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 94807 Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A56">University Paris-Sud, UMRS 1018, 94807 Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation><nlm:aff id="A55">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 94807 Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A56">University Paris-Sud, UMRS 1018, 94807 Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Mulot, Claire" sort="Mulot, Claire" uniqKey="Mulot C" first="Claire" last="Mulot">Claire Mulot</name><affiliation><nlm:aff id="A57">Université Paris Sorbonne Cité, UMR-S775 Inserm, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Sanchez, Marie" sort="Sanchez, Marie" uniqKey="Sanchez M" first="Marie" last="Sanchez">Marie Sanchez</name><affiliation><nlm:aff id="A55">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 94807 Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A56">University Paris-Sud, UMRS 1018, 94807 Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="A58">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A59">Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><affiliation><nlm:aff id="A58">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A60">National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Surowy, Harald" sort="Surowy, Harald" uniqKey="Surowy H" first="Harald" last="Surowy">Harald Surowy</name><affiliation><nlm:aff id="A58">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A59">Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Sohn, Christof" sort="Sohn, Christof" uniqKey="Sohn C" first="Christof" last="Sohn">Christof Sohn</name><affiliation><nlm:aff id="A58">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Wu, Anna H" sort="Wu, Anna H" uniqKey="Wu A" first="Anna H" last="Wu">Anna H. Wu</name><affiliation><nlm:aff id="A33">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Tseng, Chiu Chen" sort="Tseng, Chiu Chen" uniqKey="Tseng C" first="Chiu-Chen" last="Tseng">Chiu-Chen Tseng</name><affiliation><nlm:aff id="A33">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Van Den Berg, David" sort="Van Den Berg, David" uniqKey="Van Den Berg D" first="David" last="Van Den Berg">David Van Den Berg</name><affiliation><nlm:aff id="A33">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Stram, Daniel O" sort="Stram, Daniel O" uniqKey="Stram D" first="Daniel O" last="Stram">Daniel O. Stram</name><affiliation><nlm:aff id="A33">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name><affiliation><nlm:aff id="A61">Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="A61">Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A62">Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia, Spain</nlm:aff></affiliation></author><author><name sortKey="Zamora, M Pilar" sort="Zamora, M Pilar" uniqKey="Zamora M" first="M Pilar" last="Zamora">M Pilar Zamora</name><affiliation><nlm:aff id="A63">Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Perez, Jose Ignacio Arias" sort="Perez, Jose Ignacio Arias" uniqKey="Perez J" first="Jose Ignacio Arias" last="Perez">Jose Ignacio Arias Perez</name><affiliation><nlm:aff id="A64">Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain</nlm:aff></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation><nlm:aff id="A65">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Lu, Wei" sort="Lu, Wei" uniqKey="Lu W" first="Wei" last="Lu">Wei Lu</name><affiliation><nlm:aff id="A66">Shanghai Center for Disease Control and Prevention, Changning, Shanghai, China</nlm:aff></affiliation></author><author><name sortKey="Gao, Yu Tang" sort="Gao, Yu Tang" uniqKey="Gao Y" first="Yu-Tang" last="Gao">Yu-Tang Gao</name><affiliation><nlm:aff id="A67">Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China</nlm:aff></affiliation></author><author><name sortKey="Cai, Hui" sort="Cai, Hui" uniqKey="Cai H" first="Hui" last="Cai">Hui Cai</name><affiliation><nlm:aff id="A65">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="A68">Sheffield Cancer Research Centre, University of Sheffield, Sheffield, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A69">Department of Oncology, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S" last="Cross">Simon S. Cross</name><affiliation><nlm:aff id="A70">Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Reed, Malcolm Wr" sort="Reed, Malcolm Wr" uniqKey="Reed M" first="Malcolm Wr" last="Reed">Malcolm Wr Reed</name><affiliation><nlm:aff id="A68">Sheffield Cancer Research Centre, University of Sheffield, Sheffield, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A69">Department of Oncology, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L" last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="A71">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A" last="Knight">Julia A. Knight</name><affiliation><nlm:aff id="A73">Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A74">Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="A71">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation><nlm:aff id="A75">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A76">Laboratory Medicine Program, University Health Network, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J" last="Sawyer">Elinor J. Sawyer</name><affiliation><nlm:aff id="A77">Research Oncology, Division of Cancer Studies, King’s College London, Guy’s Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation><nlm:aff id="A78">Wellcome Trust Centre for Human Genetics, University of Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A79">Oxford Biomedical Research Centre, University of Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Kerin, Michael J" sort="Kerin, Michael J" uniqKey="Kerin M" first="Michael J" last="Kerin">Michael J. Kerin</name><affiliation><nlm:aff id="A80">Surgery, School of Medicine, National University of Ireland, Galway</nlm:aff></affiliation></author><author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name><affiliation><nlm:aff id="A80">Surgery, School of Medicine, National University of Ireland, Galway</nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff id="A81">Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation><nlm:aff id="A82">Department of Oncology - Pathology, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Teo, Soo Hwang" sort="Teo, Soo Hwang" uniqKey="Teo S" first="Soo Hwang" last="Teo">Soo Hwang Teo</name><affiliation><nlm:aff id="A83">Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia</nlm:aff></affiliation><affiliation><nlm:aff id="A84">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Yip, Cheng Har" sort="Yip, Cheng Har" uniqKey="Yip C" first="Cheng Har" last="Yip">Cheng Har Yip</name><affiliation><nlm:aff id="A84">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Taib, Nur Aishah Mohd" sort="Taib, Nur Aishah Mohd" uniqKey="Taib N" first="Nur Aishah Mohd" last="Taib">Nur Aishah Mohd Taib</name><affiliation><nlm:aff id="A84">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Tan, Gie Hooi" sort="Tan, Gie Hooi" uniqKey="Tan G" first="Gie-Hooi" last="Tan">Gie-Hooi Tan</name><affiliation><nlm:aff id="A84">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J" last="Hooning">Maartje J. Hooning</name><affiliation><nlm:aff id="A85">Department of Medical Oncology, Erasmus MC Cancer Institute, 3008 AE Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation><nlm:aff id="A85">Department of Medical Oncology, Erasmus MC Cancer Institute, 3008 AE Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Martens, John Wm" sort="Martens, John Wm" uniqKey="Martens J" first="John Wm" last="Martens">John Wm Martens</name><affiliation><nlm:aff id="A85">Department of Medical Oncology, Erasmus MC Cancer Institute, 3008 AE Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Collee, J Margriet" sort="Collee, J Margriet" uniqKey="Collee J" first="J Margriet" last="Collée">J Margriet Collée</name><affiliation><nlm:aff id="A86">Department of Clinical Genetics, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Blot, William" sort="Blot, William" uniqKey="Blot W" first="William" last="Blot">William Blot</name><affiliation><nlm:aff id="A65">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A87">International Epidemiology Institute, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Signorello, Lisa B" sort="Signorello, Lisa B" uniqKey="Signorello L" first="Lisa B" last="Signorello">Lisa B. Signorello</name><affiliation><nlm:aff id="A88">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Cai, Qiuyin" sort="Cai, Qiuyin" uniqKey="Cai Q" first="Qiuyin" last="Cai">Qiuyin Cai</name><affiliation><nlm:aff id="A65">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="A89">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="A90">Department of Pathology, The University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Tsimiklis, Helen" sort="Tsimiklis, Helen" uniqKey="Tsimiklis H" first="Helen" last="Tsimiklis">Helen Tsimiklis</name><affiliation><nlm:aff id="A90">Department of Pathology, The University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation><nlm:aff id="A89">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia</nlm:aff></affiliation></author><author><name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name><affiliation><nlm:aff id="A91">Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</nlm:aff></affiliation><affiliation><nlm:aff id="A92">Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</nlm:aff></affiliation><affiliation><nlm:aff id="A93">School of Public Health, China Medical University, Taichung, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Hsiung, Chia Ni" sort="Hsiung, Chia Ni" uniqKey="Hsiung C" first="Chia-Ni" last="Hsiung">Chia-Ni Hsiung</name><affiliation><nlm:aff id="A92">Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Wu, Pei Ei" sort="Wu, Pei Ei" uniqKey="Wu P" first="Pei-Ei" last="Wu">Pei-Ei Wu</name><affiliation><nlm:aff id="A91">Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</nlm:aff></affiliation><affiliation><nlm:aff id="A92">Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Hou, Ming Feng" sort="Hou, Ming Feng" uniqKey="Hou M" first="Ming-Feng" last="Hou">Ming-Feng Hou</name><affiliation><nlm:aff id="A94">Cancer Center, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan</nlm:aff></affiliation><affiliation><nlm:aff id="A95">Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Kristensen, Vessela N" sort="Kristensen, Vessela N" uniqKey="Kristensen V" first="Vessela N" last="Kristensen">Vessela N. Kristensen</name><affiliation><nlm:aff id="A96">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A97">Institute of Clinical Medicine, University of Oslo (UiO), Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A98">Department of Clinical Molecular Biology (EpiGen), University of Oslo (UiO), Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Nord, Silje" sort="Nord, Silje" uniqKey="Nord S" first="Silje" last="Nord">Silje Nord</name><affiliation><nlm:aff id="A96">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Alnaes, Grethe I Grenaker" sort="Alnaes, Grethe I Grenaker" uniqKey="Alnaes G" first="Grethe I Grenaker" last="Alnaes">Grethe I Grenaker Alnaes</name><affiliation><nlm:aff id="A96">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="A89">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A99">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia</nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L" last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="A89">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A99">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia</nlm:aff></affiliation></author><author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name><affiliation><nlm:aff id="A100">Anatomical Pathology, The Alfred Hospital, Melbourne, VIC, Australia</nlm:aff></affiliation></author><author><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name><affiliation><nlm:aff id="A101">Genomic Epidemiology Group, German Cancer Research Center (Deutsches Krebsforschungszentrum; DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Trichopoulos, Dmitrios" sort="Trichopoulos, Dmitrios" uniqKey="Trichopoulos D" first="Dmitrios" last="Trichopoulos">Dmitrios Trichopoulos</name><affiliation><nlm:aff id="A88">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A102">Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece; Hellenic Health Foundation, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Peeters, Petra" sort="Peeters, Petra" uniqKey="Peeters P" first="Petra" last="Peeters">Petra Peeters</name><affiliation><nlm:aff id="A103">Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A104">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK</nlm:aff></affiliation></author><author><name sortKey="Lund, Eiliv" sort="Lund, Eiliv" uniqKey="Lund E" first="Eiliv" last="Lund">Eiliv Lund</name><affiliation><nlm:aff id="A105">Department of Community Medicine, Faculty of Health Sciences, University of Tromsø - The Arctic University of Norway, Tromsø, Norway</nlm:aff></affiliation></author><author><name sortKey="Sund, Malin" sort="Sund, Malin" uniqKey="Sund M" first="Malin" last="Sund">Malin Sund</name><affiliation><nlm:aff id="A106">Department of Surgical and Perioperative Sciences, Umea University, Sweden</nlm:aff></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation><nlm:aff id="A107">School of Clinical Medicine, Cambridge Institute of Public Health, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J" last="Gunter">Marc J. Gunter</name><affiliation><nlm:aff id="A104">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK</nlm:aff></affiliation></author><author><name sortKey="Palli, Domenico" sort="Palli, Domenico" uniqKey="Palli D" first="Domenico" last="Palli">Domenico Palli</name><affiliation><nlm:aff id="A108">Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute, ISPO, Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Mortensen, Lotte Maxild" sort="Mortensen, Lotte Maxild" uniqKey="Mortensen L" first="Lotte Maxild" last="Mortensen">Lotte Maxild Mortensen</name><affiliation><nlm:aff id="A109">Section for Epidemiology, Aarhus University, Aarhus, Denmark</nlm:aff></affiliation></author><author><name sortKey="Dossus, Laure" sort="Dossus, Laure" uniqKey="Dossus L" first="Laure" last="Dossus">Laure Dossus</name><affiliation><nlm:aff id="A110">Inserm Centre for research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women’s Health team, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A111">Univ Paris Sud, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Huerta, Jose Maria" sort="Huerta, Jose Maria" uniqKey="Huerta J" first="Jose-Maria" last="Huerta">Jose-Maria Huerta</name><affiliation><nlm:aff id="A112">Department of Epidemiology, Consejeria de Sanidad y Politica Social, CIBER de Epidemiologia y Salud Publica, Murcia, Spain</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="A113">Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K" last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="A114">Center for Hereditary Breast and Ovarian Cancer, University Hospital Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A115">Center for Integrated Oncology (CIO), University Hospital Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A116">Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine, University of Cologne, Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Sutter, Christian" sort="Sutter, Christian" uniqKey="Sutter C" first="Christian" last="Sutter">Christian Sutter</name><affiliation><nlm:aff id="A117">Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Yang, Rongxi" sort="Yang, Rongxi" uniqKey="Yang R" first="Rongxi" last="Yang">Rongxi Yang</name><affiliation><nlm:aff id="A58">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A59">Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation><nlm:aff id="A118">Division of Health Sciences, Warwick Medical school, Warwick University, Coventry, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A119">Institute of Population Health, University of Manchester, Manchester, UK</nlm:aff></affiliation></author><author><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name><affiliation><nlm:aff id="A118">Division of Health Sciences, Warwick Medical school, Warwick University, Coventry, UK</nlm:aff></affiliation></author><author><name sortKey="Stewart Brown, Sarah" sort="Stewart Brown, Sarah" uniqKey="Stewart Brown S" first="Sarah" last="Stewart-Brown">Sarah Stewart-Brown</name><affiliation><nlm:aff id="A118">Division of Health Sciences, Warwick Medical school, Warwick University, Coventry, UK</nlm:aff></affiliation></author><author><name sortKey="Siriwanarangsan, Pornthep" sort="Siriwanarangsan, Pornthep" uniqKey="Siriwanarangsan P" first="Pornthep" last="Siriwanarangsan">Pornthep Siriwanarangsan</name><affiliation><nlm:aff id="A120">Ministry of Public Health, Nonthaburi, Thailand</nlm:aff></affiliation></author><author><name sortKey="Hartman, Mikael" sort="Hartman, Mikael" uniqKey="Hartman M" first="Mikael" last="Hartman">Mikael Hartman</name><affiliation><nlm:aff id="A121">Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="A122">Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Miao, Hui" sort="Miao, Hui" uniqKey="Miao H" first="Hui" last="Miao">Hui Miao</name><affiliation><nlm:aff id="A122">Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Chia, Kee Seng" sort="Chia, Kee Seng" uniqKey="Chia K" first="Kee Seng" last="Chia">Kee Seng Chia</name><affiliation><nlm:aff id="A122">Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Chan, Ching Wan" sort="Chan, Ching Wan" uniqKey="Chan C" first="Ching Wan" last="Chan">Ching Wan Chan</name><affiliation><nlm:aff id="A123">Division of General Surgery, National University Health System</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A" last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="A124">University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A125">University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Hein, Alexander" sort="Hein, Alexander" uniqKey="Hein A" first="Alexander" last="Hein">Alexander Hein</name><affiliation><nlm:aff id="A124">University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W" last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="A124">University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Haeberle, Lothar" sort="Haeberle, Lothar" uniqKey="Haeberle L" first="Lothar" last="Haeberle">Lothar Haeberle</name><affiliation><nlm:aff id="A124">University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="A126">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A127">German Cancer Consortium (DKTK), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Dieffenbach, Aida Karina" sort="Dieffenbach, Aida Karina" uniqKey="Dieffenbach A" first="Aida Karina" last="Dieffenbach">Aida Karina Dieffenbach</name><affiliation><nlm:aff id="A126">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A127">German Cancer Consortium (DKTK), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="A126">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name><affiliation><nlm:aff id="A128">Saarland Cancer Registry, Saarbrücken, Germany</nlm:aff></affiliation></author><author><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name><affiliation><nlm:aff id="A12">Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><affiliation><nlm:aff id="A12">Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Schoemaker, Minouk J" sort="Schoemaker, Minouk J" uniqKey="Schoemaker M" first="Minouk J" last="Schoemaker">Minouk J. Schoemaker</name><affiliation><nlm:aff id="A11">Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony J" sort="Swerdlow, Anthony J" uniqKey="Swerdlow A" first="Anthony J" last="Swerdlow">Anthony J. Swerdlow</name><affiliation><nlm:aff id="A11">Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A129">Division of Breast Cancer Research, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Brinton, Louise" sort="Brinton, Louise" uniqKey="Brinton L" first="Louise" last="Brinton">Louise Brinton</name><affiliation><nlm:aff id="A37">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name><affiliation><nlm:aff id="A11">Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:aff id="A65">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Halverson, Sandra L" sort="Halverson, Sandra L" uniqKey="Halverson S" first="Sandra L" last="Halverson">Sandra L. Halverson</name><affiliation><nlm:aff id="A65">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Shrubsole, Martha" sort="Shrubsole, Martha" uniqKey="Shrubsole M" first="Martha" last="Shrubsole">Martha Shrubsole</name><affiliation><nlm:aff id="A65">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Long, Jirong" sort="Long, Jirong" uniqKey="Long J" first="Jirong" last="Long">Jirong Long</name><affiliation><nlm:aff id="A65">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Goldberg, Mark S" sort="Goldberg, Mark S" uniqKey="Goldberg M" first="Mark S" last="Goldberg">Mark S. Goldberg</name><affiliation><nlm:aff id="A130">Department of Medicine, McGill University, Montreal, QC, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A131">Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, Montreal, QC, Canada</nlm:aff></affiliation></author><author><name sortKey="Labreche, France" sort="Labreche, France" uniqKey="Labreche F" first="France" last="Labrèche">France Labrèche</name><affiliation><nlm:aff id="A132">Département de Santé environnementale et santé au travail, École de santé publique, Université de Montréal, Montreal, Quebec, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A133">Département de Médecine sociale et préventive, École de santé publique, Université de Montréal, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name><affiliation><nlm:aff id="A134">Centre Hospitalier Universitaire de Québec Research Center, Quebec City, Quebec, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A135">Laval University, Quebec City, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="A136">Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu/Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation><nlm:aff id="A136">Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu/Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name><affiliation><nlm:aff id="A137">Department of Oncology, Oulu University Hospital, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Grip, Mervi" sort="Grip, Mervi" uniqKey="Grip M" first="Mervi" last="Grip">Mervi Grip</name><affiliation><nlm:aff id="A138">Department of Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="A127">German Cancer Consortium (DKTK), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A139">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A140">University of Tübingen, Tübingen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A141">German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="A142">Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><affiliation><nlm:aff id="A143">Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany</nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="A144">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="A145">Fondazione Istituto FIRC (Italian Foundation for Cancer Research) di Oncologia Molecolare (IFOM), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="A146">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Bernard, Loris" sort="Bernard, Loris" uniqKey="Bernard L" first="Loris" last="Bernard">Loris Bernard</name><affiliation><nlm:aff id="A147">Department of Experimental Oncology, Istituto Europeo di Oncologia, Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A148">Cogentech Cancer Genetic Test Laboratory, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V" last="Bogdanova">Natalia V. Bogdanova</name><affiliation><nlm:aff id="A149">Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="A150">Gynaecology Research Unit, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff id="A151">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A152">Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A153">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name><affiliation><nlm:aff id="A154">Cancer Center, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A155">Central Finland Hospital District, Jyväskylä Central Hospital, Jyväskylä, Finland</nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff id="A151">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A152">Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A153">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M" last="Hartikainen">Jaana M. Hartikainen</name><affiliation><nlm:aff id="A151">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A152">Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A153">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:aff id="A156">Department of Human Genetics and Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Tollenaar, Robert Aem" sort="Tollenaar, Robert Aem" uniqKey="Tollenaar R" first="Robert Aem" last="Tollenaar">Robert Aem Tollenaar</name><affiliation><nlm:aff id="A157">Department of Surgical Oncology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name><affiliation><nlm:aff id="A158">Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Asperen, Christi J" sort="Van Asperen, Christi J" uniqKey="Van Asperen C" first="Christi J" last="Van Asperen">Christi J. Van Asperen</name><affiliation><nlm:aff id="A159">Department of Clinical Genetics, Leiden University Medical Center Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="A160">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="A160">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Jaworska, Katarzyna" sort="Jaworska, Katarzyna" uniqKey="Jaworska K" first="Katarzyna" last="Jaworska">Katarzyna Jaworska</name><affiliation><nlm:aff id="A160">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Huzarski, Tomasz" sort="Huzarski, Tomasz" uniqKey="Huzarski T" first="Tomasz" last="Huzarski">Tomasz Huzarski</name><affiliation><nlm:aff id="A160">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Sangrajrang, Suleeporn" sort="Sangrajrang, Suleeporn" uniqKey="Sangrajrang S" first="Suleeporn" last="Sangrajrang">Suleeporn Sangrajrang</name><affiliation><nlm:aff id="A161">National Cancer Institute, Bangkok, Thailand</nlm:aff></affiliation></author><author><name sortKey="Gaborieau, Valerie" sort="Gaborieau, Valerie" uniqKey="Gaborieau V" first="Valerie" last="Gaborieau">Valerie Gaborieau</name><affiliation><nlm:aff id="A162">International Agency for Research on Cancer, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation><nlm:aff id="A162">International Agency for Research on Cancer, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Mckay, James" sort="Mckay, James" uniqKey="Mckay J" first="James" last="Mckay">James Mckay</name><affiliation><nlm:aff id="A162">International Agency for Research on Cancer, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Slager, Susan" sort="Slager, Susan" uniqKey="Slager S" first="Susan" last="Slager">Susan Slager</name><affiliation><nlm:aff id="A43">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E" last="Toland">Amanda E. Toland</name><affiliation><nlm:aff id="A163">Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH, USA</nlm:aff></affiliation></author><author><name sortKey="Ambrosone, Christine B" sort="Ambrosone, Christine B" uniqKey="Ambrosone C" first="Christine B" last="Ambrosone">Christine B. Ambrosone</name><affiliation><nlm:aff id="A164">Roswell Park Cancer Institute, Buffalo, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name><affiliation><nlm:aff id="A165">Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research “Demokritos”, Aghia Paraskevi Attikis, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Kabisch, Maria" sort="Kabisch, Maria" uniqKey="Kabisch M" first="Maria" last="Kabisch">Maria Kabisch</name><affiliation><nlm:aff id="A142">Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name><affiliation><nlm:aff id="A142">Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A166">Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota, Colombia</nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L" last="Neuhausen">Susan L. Neuhausen</name><affiliation><nlm:aff id="A167">Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA</nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="A168">Department of Epidemiology, University of California Irvine, Irvine, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Luccarini, Craig" sort="Luccarini, Craig" uniqKey="Luccarini C" first="Craig" last="Luccarini">Craig Luccarini</name><affiliation><nlm:aff id="A5">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Baynes, Caroline" sort="Baynes, Caroline" uniqKey="Baynes C" first="Caroline" last="Baynes">Caroline Baynes</name><affiliation><nlm:aff id="A5">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Ahmed, Shahana" sort="Ahmed, Shahana" uniqKey="Ahmed S" first="Shahana" last="Ahmed">Shahana Ahmed</name><affiliation><nlm:aff id="A5">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Healey, Catherine S" sort="Healey, Catherine S" uniqKey="Healey C" first="Catherine S" last="Healey">Catherine S. Healey</name><affiliation><nlm:aff id="A5">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Tessier, Daniel C" sort="Tessier, Daniel C" uniqKey="Tessier D" first="Daniel C" last="Tessier">Daniel C. Tessier</name><affiliation><nlm:aff id="A169">McGill University and Génome Québec Innovation Centre, Montréal, Québec, Canada</nlm:aff></affiliation></author><author><name sortKey="Vincent, Daniel" sort="Vincent, Daniel" uniqKey="Vincent D" first="Daniel" last="Vincent">Daniel Vincent</name><affiliation><nlm:aff id="A169">McGill University and Génome Québec Innovation Centre, Montréal, Québec, Canada</nlm:aff></affiliation></author><author><name sortKey="Bacot, Francois" sort="Bacot, Francois" uniqKey="Bacot F" first="Francois" last="Bacot">Francois Bacot</name><affiliation><nlm:aff id="A169">McGill University and Génome Québec Innovation Centre, Montréal, Québec, Canada</nlm:aff></affiliation></author><author><name sortKey="Pita, Guillermo" sort="Pita, Guillermo" uniqKey="Pita G" first="Guillermo" last="Pita">Guillermo Pita</name><affiliation><nlm:aff id="A61">Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Alonso, M Rosario" sort="Alonso, M Rosario" uniqKey="Alonso M" first="M Rosario" last="Alonso">M Rosario Alonso</name><affiliation><nlm:aff id="A61">Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Alvarez, Nuria" sort="Alvarez, Nuria" uniqKey="Alvarez N" first="Nuria" last="Álvarez">Nuria Álvarez</name><affiliation><nlm:aff id="A61">Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Herrero, Daniel" sort="Herrero, Daniel" uniqKey="Herrero D" first="Daniel" last="Herrero">Daniel Herrero</name><affiliation><nlm:aff id="A61">Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="A134">Centre Hospitalier Universitaire de Québec Research Center, Quebec City, Quebec, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A135">Laval University, Quebec City, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul Pdp" sort="Pharoah, Paul Pdp" uniqKey="Pharoah P" first="Paul Pdp" last="Pharoah">Paul Pdp Pharoah</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="A3">Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M" last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="A5">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="A2">Department of Genetics, QIMR (Queensland Institute for Medical Research) Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="A6">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F" last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25751625</idno><idno type="pmc">4549775</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549775</idno><idno type="RBID">PMC:4549775</idno><idno type="doi">10.1038/ng.3242</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">002E40</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E40</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer</title><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation><nlm:aff id="A2">Department of Genetics, QIMR (Queensland Institute for Medical Research) Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindstrom">Sara Lindstrom</name><affiliation><nlm:aff id="A3">Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Canisius, Sander" sort="Canisius, Sander" uniqKey="Canisius S" first="Sander" last="Canisius">Sander Canisius</name><affiliation><nlm:aff id="A4">Division of Molecular Carcinogenesis, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Lush, Michael" sort="Lush, Michael" uniqKey="Lush M" first="Michael" last="Lush">Michael Lush</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Maranian, Mel J" sort="Maranian, Mel J" uniqKey="Maranian M" first="Mel J" last="Maranian">Mel J. Maranian</name><affiliation><nlm:aff id="A5">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K" last="Bolla">Manjeet K. Bolla</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name><affiliation><nlm:aff id="A5">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Perkins, Barbara J" sort="Perkins, Barbara J" uniqKey="Perkins B" first="Barbara J" last="Perkins">Barbara J. Perkins</name><affiliation><nlm:aff id="A5">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="A6">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Mikael" sort="Eriksson, Mikael" uniqKey="Eriksson M" first="Mikael" last="Eriksson">Mikael Eriksson</name><affiliation><nlm:aff id="A6">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name><affiliation><nlm:aff id="A6">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Brand, Judith S" sort="Brand, Judith S" uniqKey="Brand J" first="Judith S" last="Brand">Judith S. Brand</name><affiliation><nlm:aff id="A6">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E" last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="A7">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G" last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation><nlm:aff id="A7">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="A10">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nielsen, Sune F" sort="Nielsen, Sune F" uniqKey="Nielsen S" first="Sune F" last="Nielsen">Sune F. Nielsen</name><affiliation><nlm:aff id="A7">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><affiliation><nlm:aff id="A11">Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Turnbull, Clare" sort="Turnbull, Clare" uniqKey="Turnbull C" first="Clare" last="Turnbull">Clare Turnbull</name><affiliation><nlm:aff id="A11">Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="A12">Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="A13">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff></affiliation></author><author><name sortKey="Gibson, Lorna" sort="Gibson, Lorna" uniqKey="Gibson L" first="Lorna" last="Gibson">Lorna Gibson</name><affiliation><nlm:aff id="A13">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><affiliation><nlm:aff id="A13">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="A14">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="A15">Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Hamburg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="A14">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Eilber, Ursula" sort="Eilber, Ursula" uniqKey="Eilber U" first="Ursula" last="Eilber">Ursula Eilber</name><affiliation><nlm:aff id="A14">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Behrens, Sabine" sort="Behrens, Sabine" uniqKey="Behrens S" first="Sabine" last="Behrens">Sabine Behrens</name><affiliation><nlm:aff id="A14">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="A17">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A" last="Muranen">Taru A. Muranen</name><affiliation><nlm:aff id="A17">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="A18">Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation><nlm:aff id="A19">Department of Oncology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Khan, Sofia" sort="Khan, Sofia" uniqKey="Khan S" first="Sofia" last="Khan">Sofia Khan</name><affiliation><nlm:aff id="A17">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Aaltonen, Kirsimari" sort="Aaltonen, Kirsimari" uniqKey="Aaltonen K" first="Kirsimari" last="Aaltonen">Kirsimari Aaltonen</name><affiliation><nlm:aff id="A17">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Ahsan, Habibul" sort="Ahsan, Habibul" uniqKey="Ahsan H" first="Habibul" last="Ahsan">Habibul Ahsan</name><affiliation><nlm:aff id="A20">Center for Cancer Epidemiology and Prevention, University of Chicago, Chicago, Illinois</nlm:aff></affiliation><affiliation><nlm:aff id="A21">Department of Health Studies, University of Chicago, Chicago, Illinois</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Department of Medicine, University of Chicago, Chicago, Illinois</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Department of Human Genetics, University of Chicago, Chicago, Illinois</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Comprehensive Cancer Center, University of Chicago, Chicago, Illinois</nlm:aff></affiliation></author><author><name sortKey="Kibriya, Muhammad G" sort="Kibriya, Muhammad G" uniqKey="Kibriya M" first="Muhammad G" last="Kibriya">Muhammad G. Kibriya</name><affiliation><nlm:aff id="A20">Center for Cancer Epidemiology and Prevention, University of Chicago, Chicago, Illinois</nlm:aff></affiliation><affiliation><nlm:aff id="A21">Department of Health Studies, University of Chicago, Chicago, Illinois</nlm:aff></affiliation></author><author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S" last="Whittemore">Alice S. Whittemore</name><affiliation><nlm:aff id="A25">Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A26">Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M" last="John">Esther M. John</name><affiliation><nlm:aff id="A25">Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A26">Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Department of Epidemiology, Cancer Prevention Institute of California, Fremont, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Malone, Kathleen E" sort="Malone, Kathleen E" uniqKey="Malone K" first="Kathleen E" last="Malone">Kathleen E. Malone</name><affiliation><nlm:aff id="A28">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="Gammon, Marilie D" sort="Gammon, Marilie D" uniqKey="Gammon M" first="Marilie D" last="Gammon">Marilie D. Gammon</name><affiliation><nlm:aff id="A29">Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina</nlm:aff></affiliation></author><author><name sortKey="Santella, Regina M" sort="Santella, Regina M" uniqKey="Santella R" first="Regina M" last="Santella">Regina M. Santella</name><affiliation><nlm:aff id="A30">Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York</nlm:aff></affiliation></author><author><name sortKey="Ursin, Giske" sort="Ursin, Giske" uniqKey="Ursin G" first="Giske" last="Ursin">Giske Ursin</name><affiliation><nlm:aff id="A31">Norway Cancer Registry, Norway</nlm:aff></affiliation></author><author><name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name><affiliation><nlm:aff id="A32">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Daniel F" sort="Schmidt, Daniel F" uniqKey="Schmidt D" first="Daniel F" last="Schmidt">Daniel F. Schmidt</name><affiliation><nlm:aff id="A32">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><affiliation><nlm:aff id="A33">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name><affiliation><nlm:aff id="A3">Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Gapstur, Susan M" sort="Gapstur, Susan M" uniqKey="Gapstur S" first="Susan M" last="Gapstur">Susan M. Gapstur</name><affiliation><nlm:aff id="A34">Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M" last="Gaudet">Mia M. Gaudet</name><affiliation><nlm:aff id="A34">Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Diver, W Ryan" sort="Diver, W Ryan" uniqKey="Diver W" first="W Ryan" last="Diver">W Ryan Diver</name><affiliation><nlm:aff id="A34">Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A" last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="A33">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Schumacher, Fredrick" sort="Schumacher, Fredrick" uniqKey="Schumacher F" first="Fredrick" last="Schumacher">Fredrick Schumacher</name><affiliation><nlm:aff id="A33">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E" last="Henderson">Brian E. Henderson</name><affiliation><nlm:aff id="A33">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="A35">Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA</nlm:aff></affiliation></author><author><name sortKey="Berg, Christine D" sort="Berg, Christine D" uniqKey="Berg C" first="Christine D" last="Berg">Christine D. Berg</name><affiliation><nlm:aff id="A36">Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Medicine, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen" sort="Chanock, Stephen" uniqKey="Chanock S" first="Stephen" last="Chanock">Stephen Chanock</name><affiliation><nlm:aff id="A37">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name><affiliation><nlm:aff id="A37">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Hoover, Robert N" sort="Hoover, Robert N" uniqKey="Hoover R" first="Robert N" last="Hoover">Robert N. Hoover</name><affiliation><nlm:aff id="A37">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="A38">Vesalius Research Center, VIB, Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Neven, Patrick" sort="Neven, Patrick" uniqKey="Neven P" first="Patrick" last="Neven">Patrick Neven</name><affiliation><nlm:aff id="A40">Multidisciplinary Breast Center, University Hospitals Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Wildiers, Hans" sort="Wildiers, Hans" uniqKey="Wildiers H" first="Hans" last="Wildiers">Hans Wildiers</name><affiliation><nlm:aff id="A40">Multidisciplinary Breast Center, University Hospitals Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Van Limbergen, Erik" sort="Van Limbergen, Erik" uniqKey="Van Limbergen E" first="Erik" last="Van Limbergen">Erik Van Limbergen</name><affiliation><nlm:aff id="A40">Multidisciplinary Breast Center, University Hospitals Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K" last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="A41">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation><nlm:aff id="A41">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Verhoef, Senno" sort="Verhoef, Senno" uniqKey="Verhoef S" first="Senno" last="Verhoef">Senno Verhoef</name><affiliation><nlm:aff id="A41">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Cornelissen, Sten" sort="Cornelissen, Sten" uniqKey="Cornelissen S" first="Sten" last="Cornelissen">Sten Cornelissen</name><affiliation><nlm:aff id="A41">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J" last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="A42">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E" last="Olson">Janet E. Olson</name><affiliation><nlm:aff id="A43">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Hallberg, Emily" sort="Hallberg, Emily" uniqKey="Hallberg E" first="Emily" last="Hallberg">Emily Hallberg</name><affiliation><nlm:aff id="A43">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name><affiliation><nlm:aff id="A43">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Waisfisz, Quinten" sort="Waisfisz, Quinten" uniqKey="Waisfisz Q" first="Quinten" last="Waisfisz">Quinten Waisfisz</name><affiliation><nlm:aff id="A44">Department of Clinical Genetics, VU University Medical Center, section Oncogenetics, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Meijers Heijboer, Hanne" sort="Meijers Heijboer, Hanne" uniqKey="Meijers Heijboer H" first="Hanne" last="Meijers-Heijboer">Hanne Meijers-Heijboer</name><affiliation><nlm:aff id="A44">Department of Clinical Genetics, VU University Medical Center, section Oncogenetics, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Adank, Muriel A" sort="Adank, Muriel A" uniqKey="Adank M" first="Muriel A" last="Adank">Muriel A. Adank</name><affiliation><nlm:aff id="A44">Department of Clinical Genetics, VU University Medical Center, section Oncogenetics, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Der Luijt, Rob B" sort="Van Der Luijt, Rob B" uniqKey="Van Der Luijt R" first="Rob B" last="Van Der Luijt">Rob B. Van Der Luijt</name><affiliation><nlm:aff id="A45">Division of Biomedical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation><nlm:aff id="A6">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation><nlm:aff id="A46">Human Genetics Division, Genome Institute of Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name><affiliation><nlm:aff id="A6">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Kang, Daehee" sort="Kang, Daehee" uniqKey="Kang D" first="Daehee" last="Kang">Daehee Kang</name><affiliation><nlm:aff id="A47">Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A49">Cancer Research Institute, Seoul National University, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Choi, Ji Yeob" sort="Choi, Ji Yeob" uniqKey="Choi J" first="Ji-Yeob" last="Choi">Ji-Yeob Choi</name><affiliation><nlm:aff id="A48">Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A49">Cancer Research Institute, Seoul National University, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Park, Sue K" sort="Park, Sue K" uniqKey="Park S" first="Sue K" last="Park">Sue K. Park</name><affiliation><nlm:aff id="A47">Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A49">Cancer Research Institute, Seoul National University, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Yoo, Keun Young" sort="Yoo, Keun Young" uniqKey="Yoo K" first="Keun-Young" last="Yoo">Keun-Young Yoo</name><affiliation><nlm:aff id="A50">Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Matsuo, Keitaro" sort="Matsuo, Keitaro" uniqKey="Matsuo K" first="Keitaro" last="Matsuo">Keitaro Matsuo</name><affiliation><nlm:aff id="A51">Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan</nlm:aff></affiliation></author><author><name sortKey="Ito, Hidemi" sort="Ito, Hidemi" uniqKey="Ito H" first="Hidemi" last="Ito">Hidemi Ito</name><affiliation><nlm:aff id="A52">Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan</nlm:aff></affiliation></author><author><name sortKey="Iwata, Hiroji" sort="Iwata, Hiroji" uniqKey="Iwata H" first="Hiroji" last="Iwata">Hiroji Iwata</name><affiliation><nlm:aff id="A53">Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan</nlm:aff></affiliation></author><author><name sortKey="Tajima, Kazuo" sort="Tajima, Kazuo" uniqKey="Tajima K" first="Kazuo" last="Tajima">Kazuo Tajima</name><affiliation><nlm:aff id="A54">Epidemiology Center for Disease Control and Prevention, Mie University Hospital, Tsu, Mie, Japan</nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation><nlm:aff id="A55">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 94807 Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A56">University Paris-Sud, UMRS 1018, 94807 Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation><nlm:aff id="A55">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 94807 Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A56">University Paris-Sud, UMRS 1018, 94807 Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Mulot, Claire" sort="Mulot, Claire" uniqKey="Mulot C" first="Claire" last="Mulot">Claire Mulot</name><affiliation><nlm:aff id="A57">Université Paris Sorbonne Cité, UMR-S775 Inserm, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Sanchez, Marie" sort="Sanchez, Marie" uniqKey="Sanchez M" first="Marie" last="Sanchez">Marie Sanchez</name><affiliation><nlm:aff id="A55">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 94807 Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A56">University Paris-Sud, UMRS 1018, 94807 Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="A58">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A59">Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><affiliation><nlm:aff id="A58">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A60">National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Surowy, Harald" sort="Surowy, Harald" uniqKey="Surowy H" first="Harald" last="Surowy">Harald Surowy</name><affiliation><nlm:aff id="A58">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A59">Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Sohn, Christof" sort="Sohn, Christof" uniqKey="Sohn C" first="Christof" last="Sohn">Christof Sohn</name><affiliation><nlm:aff id="A58">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Wu, Anna H" sort="Wu, Anna H" uniqKey="Wu A" first="Anna H" last="Wu">Anna H. Wu</name><affiliation><nlm:aff id="A33">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Tseng, Chiu Chen" sort="Tseng, Chiu Chen" uniqKey="Tseng C" first="Chiu-Chen" last="Tseng">Chiu-Chen Tseng</name><affiliation><nlm:aff id="A33">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Van Den Berg, David" sort="Van Den Berg, David" uniqKey="Van Den Berg D" first="David" last="Van Den Berg">David Van Den Berg</name><affiliation><nlm:aff id="A33">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Stram, Daniel O" sort="Stram, Daniel O" uniqKey="Stram D" first="Daniel O" last="Stram">Daniel O. Stram</name><affiliation><nlm:aff id="A33">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name><affiliation><nlm:aff id="A61">Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="A61">Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A62">Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia, Spain</nlm:aff></affiliation></author><author><name sortKey="Zamora, M Pilar" sort="Zamora, M Pilar" uniqKey="Zamora M" first="M Pilar" last="Zamora">M Pilar Zamora</name><affiliation><nlm:aff id="A63">Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Perez, Jose Ignacio Arias" sort="Perez, Jose Ignacio Arias" uniqKey="Perez J" first="Jose Ignacio Arias" last="Perez">Jose Ignacio Arias Perez</name><affiliation><nlm:aff id="A64">Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain</nlm:aff></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation><nlm:aff id="A65">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Lu, Wei" sort="Lu, Wei" uniqKey="Lu W" first="Wei" last="Lu">Wei Lu</name><affiliation><nlm:aff id="A66">Shanghai Center for Disease Control and Prevention, Changning, Shanghai, China</nlm:aff></affiliation></author><author><name sortKey="Gao, Yu Tang" sort="Gao, Yu Tang" uniqKey="Gao Y" first="Yu-Tang" last="Gao">Yu-Tang Gao</name><affiliation><nlm:aff id="A67">Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China</nlm:aff></affiliation></author><author><name sortKey="Cai, Hui" sort="Cai, Hui" uniqKey="Cai H" first="Hui" last="Cai">Hui Cai</name><affiliation><nlm:aff id="A65">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="A68">Sheffield Cancer Research Centre, University of Sheffield, Sheffield, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A69">Department of Oncology, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S" last="Cross">Simon S. Cross</name><affiliation><nlm:aff id="A70">Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Reed, Malcolm Wr" sort="Reed, Malcolm Wr" uniqKey="Reed M" first="Malcolm Wr" last="Reed">Malcolm Wr Reed</name><affiliation><nlm:aff id="A68">Sheffield Cancer Research Centre, University of Sheffield, Sheffield, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A69">Department of Oncology, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L" last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="A71">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A" last="Knight">Julia A. Knight</name><affiliation><nlm:aff id="A73">Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A74">Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="A71">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation><nlm:aff id="A75">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A76">Laboratory Medicine Program, University Health Network, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J" last="Sawyer">Elinor J. Sawyer</name><affiliation><nlm:aff id="A77">Research Oncology, Division of Cancer Studies, King’s College London, Guy’s Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation><nlm:aff id="A78">Wellcome Trust Centre for Human Genetics, University of Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A79">Oxford Biomedical Research Centre, University of Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Kerin, Michael J" sort="Kerin, Michael J" uniqKey="Kerin M" first="Michael J" last="Kerin">Michael J. Kerin</name><affiliation><nlm:aff id="A80">Surgery, School of Medicine, National University of Ireland, Galway</nlm:aff></affiliation></author><author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name><affiliation><nlm:aff id="A80">Surgery, School of Medicine, National University of Ireland, Galway</nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff id="A81">Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation><nlm:aff id="A82">Department of Oncology - Pathology, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Teo, Soo Hwang" sort="Teo, Soo Hwang" uniqKey="Teo S" first="Soo Hwang" last="Teo">Soo Hwang Teo</name><affiliation><nlm:aff id="A83">Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia</nlm:aff></affiliation><affiliation><nlm:aff id="A84">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Yip, Cheng Har" sort="Yip, Cheng Har" uniqKey="Yip C" first="Cheng Har" last="Yip">Cheng Har Yip</name><affiliation><nlm:aff id="A84">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Taib, Nur Aishah Mohd" sort="Taib, Nur Aishah Mohd" uniqKey="Taib N" first="Nur Aishah Mohd" last="Taib">Nur Aishah Mohd Taib</name><affiliation><nlm:aff id="A84">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Tan, Gie Hooi" sort="Tan, Gie Hooi" uniqKey="Tan G" first="Gie-Hooi" last="Tan">Gie-Hooi Tan</name><affiliation><nlm:aff id="A84">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J" last="Hooning">Maartje J. Hooning</name><affiliation><nlm:aff id="A85">Department of Medical Oncology, Erasmus MC Cancer Institute, 3008 AE Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation><nlm:aff id="A85">Department of Medical Oncology, Erasmus MC Cancer Institute, 3008 AE Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Martens, John Wm" sort="Martens, John Wm" uniqKey="Martens J" first="John Wm" last="Martens">John Wm Martens</name><affiliation><nlm:aff id="A85">Department of Medical Oncology, Erasmus MC Cancer Institute, 3008 AE Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Collee, J Margriet" sort="Collee, J Margriet" uniqKey="Collee J" first="J Margriet" last="Collée">J Margriet Collée</name><affiliation><nlm:aff id="A86">Department of Clinical Genetics, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Blot, William" sort="Blot, William" uniqKey="Blot W" first="William" last="Blot">William Blot</name><affiliation><nlm:aff id="A65">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A87">International Epidemiology Institute, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Signorello, Lisa B" sort="Signorello, Lisa B" uniqKey="Signorello L" first="Lisa B" last="Signorello">Lisa B. Signorello</name><affiliation><nlm:aff id="A88">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Cai, Qiuyin" sort="Cai, Qiuyin" uniqKey="Cai Q" first="Qiuyin" last="Cai">Qiuyin Cai</name><affiliation><nlm:aff id="A65">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="A89">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="A90">Department of Pathology, The University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Tsimiklis, Helen" sort="Tsimiklis, Helen" uniqKey="Tsimiklis H" first="Helen" last="Tsimiklis">Helen Tsimiklis</name><affiliation><nlm:aff id="A90">Department of Pathology, The University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation><nlm:aff id="A89">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia</nlm:aff></affiliation></author><author><name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name><affiliation><nlm:aff id="A91">Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</nlm:aff></affiliation><affiliation><nlm:aff id="A92">Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</nlm:aff></affiliation><affiliation><nlm:aff id="A93">School of Public Health, China Medical University, Taichung, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Hsiung, Chia Ni" sort="Hsiung, Chia Ni" uniqKey="Hsiung C" first="Chia-Ni" last="Hsiung">Chia-Ni Hsiung</name><affiliation><nlm:aff id="A92">Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Wu, Pei Ei" sort="Wu, Pei Ei" uniqKey="Wu P" first="Pei-Ei" last="Wu">Pei-Ei Wu</name><affiliation><nlm:aff id="A91">Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</nlm:aff></affiliation><affiliation><nlm:aff id="A92">Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Hou, Ming Feng" sort="Hou, Ming Feng" uniqKey="Hou M" first="Ming-Feng" last="Hou">Ming-Feng Hou</name><affiliation><nlm:aff id="A94">Cancer Center, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan</nlm:aff></affiliation><affiliation><nlm:aff id="A95">Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Kristensen, Vessela N" sort="Kristensen, Vessela N" uniqKey="Kristensen V" first="Vessela N" last="Kristensen">Vessela N. Kristensen</name><affiliation><nlm:aff id="A96">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A97">Institute of Clinical Medicine, University of Oslo (UiO), Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A98">Department of Clinical Molecular Biology (EpiGen), University of Oslo (UiO), Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Nord, Silje" sort="Nord, Silje" uniqKey="Nord S" first="Silje" last="Nord">Silje Nord</name><affiliation><nlm:aff id="A96">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Alnaes, Grethe I Grenaker" sort="Alnaes, Grethe I Grenaker" uniqKey="Alnaes G" first="Grethe I Grenaker" last="Alnaes">Grethe I Grenaker Alnaes</name><affiliation><nlm:aff id="A96">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="A89">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A99">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia</nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L" last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="A89">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A99">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia</nlm:aff></affiliation></author><author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name><affiliation><nlm:aff id="A100">Anatomical Pathology, The Alfred Hospital, Melbourne, VIC, Australia</nlm:aff></affiliation></author><author><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name><affiliation><nlm:aff id="A101">Genomic Epidemiology Group, German Cancer Research Center (Deutsches Krebsforschungszentrum; DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Trichopoulos, Dmitrios" sort="Trichopoulos, Dmitrios" uniqKey="Trichopoulos D" first="Dmitrios" last="Trichopoulos">Dmitrios Trichopoulos</name><affiliation><nlm:aff id="A88">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A102">Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece; Hellenic Health Foundation, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Peeters, Petra" sort="Peeters, Petra" uniqKey="Peeters P" first="Petra" last="Peeters">Petra Peeters</name><affiliation><nlm:aff id="A103">Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A104">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK</nlm:aff></affiliation></author><author><name sortKey="Lund, Eiliv" sort="Lund, Eiliv" uniqKey="Lund E" first="Eiliv" last="Lund">Eiliv Lund</name><affiliation><nlm:aff id="A105">Department of Community Medicine, Faculty of Health Sciences, University of Tromsø - The Arctic University of Norway, Tromsø, Norway</nlm:aff></affiliation></author><author><name sortKey="Sund, Malin" sort="Sund, Malin" uniqKey="Sund M" first="Malin" last="Sund">Malin Sund</name><affiliation><nlm:aff id="A106">Department of Surgical and Perioperative Sciences, Umea University, Sweden</nlm:aff></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation><nlm:aff id="A107">School of Clinical Medicine, Cambridge Institute of Public Health, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J" last="Gunter">Marc J. Gunter</name><affiliation><nlm:aff id="A104">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK</nlm:aff></affiliation></author><author><name sortKey="Palli, Domenico" sort="Palli, Domenico" uniqKey="Palli D" first="Domenico" last="Palli">Domenico Palli</name><affiliation><nlm:aff id="A108">Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute, ISPO, Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Mortensen, Lotte Maxild" sort="Mortensen, Lotte Maxild" uniqKey="Mortensen L" first="Lotte Maxild" last="Mortensen">Lotte Maxild Mortensen</name><affiliation><nlm:aff id="A109">Section for Epidemiology, Aarhus University, Aarhus, Denmark</nlm:aff></affiliation></author><author><name sortKey="Dossus, Laure" sort="Dossus, Laure" uniqKey="Dossus L" first="Laure" last="Dossus">Laure Dossus</name><affiliation><nlm:aff id="A110">Inserm Centre for research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women’s Health team, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A111">Univ Paris Sud, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Huerta, Jose Maria" sort="Huerta, Jose Maria" uniqKey="Huerta J" first="Jose-Maria" last="Huerta">Jose-Maria Huerta</name><affiliation><nlm:aff id="A112">Department of Epidemiology, Consejeria de Sanidad y Politica Social, CIBER de Epidemiologia y Salud Publica, Murcia, Spain</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="A113">Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K" last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="A114">Center for Hereditary Breast and Ovarian Cancer, University Hospital Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A115">Center for Integrated Oncology (CIO), University Hospital Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A116">Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine, University of Cologne, Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Sutter, Christian" sort="Sutter, Christian" uniqKey="Sutter C" first="Christian" last="Sutter">Christian Sutter</name><affiliation><nlm:aff id="A117">Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Yang, Rongxi" sort="Yang, Rongxi" uniqKey="Yang R" first="Rongxi" last="Yang">Rongxi Yang</name><affiliation><nlm:aff id="A58">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A59">Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation><nlm:aff id="A118">Division of Health Sciences, Warwick Medical school, Warwick University, Coventry, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A119">Institute of Population Health, University of Manchester, Manchester, UK</nlm:aff></affiliation></author><author><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name><affiliation><nlm:aff id="A118">Division of Health Sciences, Warwick Medical school, Warwick University, Coventry, UK</nlm:aff></affiliation></author><author><name sortKey="Stewart Brown, Sarah" sort="Stewart Brown, Sarah" uniqKey="Stewart Brown S" first="Sarah" last="Stewart-Brown">Sarah Stewart-Brown</name><affiliation><nlm:aff id="A118">Division of Health Sciences, Warwick Medical school, Warwick University, Coventry, UK</nlm:aff></affiliation></author><author><name sortKey="Siriwanarangsan, Pornthep" sort="Siriwanarangsan, Pornthep" uniqKey="Siriwanarangsan P" first="Pornthep" last="Siriwanarangsan">Pornthep Siriwanarangsan</name><affiliation><nlm:aff id="A120">Ministry of Public Health, Nonthaburi, Thailand</nlm:aff></affiliation></author><author><name sortKey="Hartman, Mikael" sort="Hartman, Mikael" uniqKey="Hartman M" first="Mikael" last="Hartman">Mikael Hartman</name><affiliation><nlm:aff id="A121">Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="A122">Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Miao, Hui" sort="Miao, Hui" uniqKey="Miao H" first="Hui" last="Miao">Hui Miao</name><affiliation><nlm:aff id="A122">Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Chia, Kee Seng" sort="Chia, Kee Seng" uniqKey="Chia K" first="Kee Seng" last="Chia">Kee Seng Chia</name><affiliation><nlm:aff id="A122">Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Chan, Ching Wan" sort="Chan, Ching Wan" uniqKey="Chan C" first="Ching Wan" last="Chan">Ching Wan Chan</name><affiliation><nlm:aff id="A123">Division of General Surgery, National University Health System</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A" last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="A124">University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A125">University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Hein, Alexander" sort="Hein, Alexander" uniqKey="Hein A" first="Alexander" last="Hein">Alexander Hein</name><affiliation><nlm:aff id="A124">University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W" last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="A124">University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Haeberle, Lothar" sort="Haeberle, Lothar" uniqKey="Haeberle L" first="Lothar" last="Haeberle">Lothar Haeberle</name><affiliation><nlm:aff id="A124">University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="A126">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A127">German Cancer Consortium (DKTK), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Dieffenbach, Aida Karina" sort="Dieffenbach, Aida Karina" uniqKey="Dieffenbach A" first="Aida Karina" last="Dieffenbach">Aida Karina Dieffenbach</name><affiliation><nlm:aff id="A126">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A127">German Cancer Consortium (DKTK), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="A126">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name><affiliation><nlm:aff id="A128">Saarland Cancer Registry, Saarbrücken, Germany</nlm:aff></affiliation></author><author><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name><affiliation><nlm:aff id="A12">Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><affiliation><nlm:aff id="A12">Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Schoemaker, Minouk J" sort="Schoemaker, Minouk J" uniqKey="Schoemaker M" first="Minouk J" last="Schoemaker">Minouk J. Schoemaker</name><affiliation><nlm:aff id="A11">Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony J" sort="Swerdlow, Anthony J" uniqKey="Swerdlow A" first="Anthony J" last="Swerdlow">Anthony J. Swerdlow</name><affiliation><nlm:aff id="A11">Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A129">Division of Breast Cancer Research, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Brinton, Louise" sort="Brinton, Louise" uniqKey="Brinton L" first="Louise" last="Brinton">Louise Brinton</name><affiliation><nlm:aff id="A37">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name><affiliation><nlm:aff id="A11">Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:aff id="A65">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Halverson, Sandra L" sort="Halverson, Sandra L" uniqKey="Halverson S" first="Sandra L" last="Halverson">Sandra L. Halverson</name><affiliation><nlm:aff id="A65">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Shrubsole, Martha" sort="Shrubsole, Martha" uniqKey="Shrubsole M" first="Martha" last="Shrubsole">Martha Shrubsole</name><affiliation><nlm:aff id="A65">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Long, Jirong" sort="Long, Jirong" uniqKey="Long J" first="Jirong" last="Long">Jirong Long</name><affiliation><nlm:aff id="A65">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Goldberg, Mark S" sort="Goldberg, Mark S" uniqKey="Goldberg M" first="Mark S" last="Goldberg">Mark S. Goldberg</name><affiliation><nlm:aff id="A130">Department of Medicine, McGill University, Montreal, QC, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A131">Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, Montreal, QC, Canada</nlm:aff></affiliation></author><author><name sortKey="Labreche, France" sort="Labreche, France" uniqKey="Labreche F" first="France" last="Labrèche">France Labrèche</name><affiliation><nlm:aff id="A132">Département de Santé environnementale et santé au travail, École de santé publique, Université de Montréal, Montreal, Quebec, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A133">Département de Médecine sociale et préventive, École de santé publique, Université de Montréal, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name><affiliation><nlm:aff id="A134">Centre Hospitalier Universitaire de Québec Research Center, Quebec City, Quebec, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A135">Laval University, Quebec City, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="A136">Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu/Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation><nlm:aff id="A136">Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu/Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name><affiliation><nlm:aff id="A137">Department of Oncology, Oulu University Hospital, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Grip, Mervi" sort="Grip, Mervi" uniqKey="Grip M" first="Mervi" last="Grip">Mervi Grip</name><affiliation><nlm:aff id="A138">Department of Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="A127">German Cancer Consortium (DKTK), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A139">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A140">University of Tübingen, Tübingen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A141">German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="A142">Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><affiliation><nlm:aff id="A143">Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany</nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="A144">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="A145">Fondazione Istituto FIRC (Italian Foundation for Cancer Research) di Oncologia Molecolare (IFOM), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="A146">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Bernard, Loris" sort="Bernard, Loris" uniqKey="Bernard L" first="Loris" last="Bernard">Loris Bernard</name><affiliation><nlm:aff id="A147">Department of Experimental Oncology, Istituto Europeo di Oncologia, Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A148">Cogentech Cancer Genetic Test Laboratory, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V" last="Bogdanova">Natalia V. Bogdanova</name><affiliation><nlm:aff id="A149">Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="A150">Gynaecology Research Unit, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff id="A151">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A152">Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A153">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name><affiliation><nlm:aff id="A154">Cancer Center, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A155">Central Finland Hospital District, Jyväskylä Central Hospital, Jyväskylä, Finland</nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff id="A151">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A152">Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A153">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M" last="Hartikainen">Jaana M. Hartikainen</name><affiliation><nlm:aff id="A151">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A152">Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A153">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:aff id="A156">Department of Human Genetics and Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Tollenaar, Robert Aem" sort="Tollenaar, Robert Aem" uniqKey="Tollenaar R" first="Robert Aem" last="Tollenaar">Robert Aem Tollenaar</name><affiliation><nlm:aff id="A157">Department of Surgical Oncology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name><affiliation><nlm:aff id="A158">Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Asperen, Christi J" sort="Van Asperen, Christi J" uniqKey="Van Asperen C" first="Christi J" last="Van Asperen">Christi J. Van Asperen</name><affiliation><nlm:aff id="A159">Department of Clinical Genetics, Leiden University Medical Center Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="A160">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="A160">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Jaworska, Katarzyna" sort="Jaworska, Katarzyna" uniqKey="Jaworska K" first="Katarzyna" last="Jaworska">Katarzyna Jaworska</name><affiliation><nlm:aff id="A160">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Huzarski, Tomasz" sort="Huzarski, Tomasz" uniqKey="Huzarski T" first="Tomasz" last="Huzarski">Tomasz Huzarski</name><affiliation><nlm:aff id="A160">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Sangrajrang, Suleeporn" sort="Sangrajrang, Suleeporn" uniqKey="Sangrajrang S" first="Suleeporn" last="Sangrajrang">Suleeporn Sangrajrang</name><affiliation><nlm:aff id="A161">National Cancer Institute, Bangkok, Thailand</nlm:aff></affiliation></author><author><name sortKey="Gaborieau, Valerie" sort="Gaborieau, Valerie" uniqKey="Gaborieau V" first="Valerie" last="Gaborieau">Valerie Gaborieau</name><affiliation><nlm:aff id="A162">International Agency for Research on Cancer, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation><nlm:aff id="A162">International Agency for Research on Cancer, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Mckay, James" sort="Mckay, James" uniqKey="Mckay J" first="James" last="Mckay">James Mckay</name><affiliation><nlm:aff id="A162">International Agency for Research on Cancer, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Slager, Susan" sort="Slager, Susan" uniqKey="Slager S" first="Susan" last="Slager">Susan Slager</name><affiliation><nlm:aff id="A43">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E" last="Toland">Amanda E. Toland</name><affiliation><nlm:aff id="A163">Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH, USA</nlm:aff></affiliation></author><author><name sortKey="Ambrosone, Christine B" sort="Ambrosone, Christine B" uniqKey="Ambrosone C" first="Christine B" last="Ambrosone">Christine B. Ambrosone</name><affiliation><nlm:aff id="A164">Roswell Park Cancer Institute, Buffalo, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name><affiliation><nlm:aff id="A165">Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research “Demokritos”, Aghia Paraskevi Attikis, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Kabisch, Maria" sort="Kabisch, Maria" uniqKey="Kabisch M" first="Maria" last="Kabisch">Maria Kabisch</name><affiliation><nlm:aff id="A142">Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name><affiliation><nlm:aff id="A142">Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A166">Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota, Colombia</nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L" last="Neuhausen">Susan L. Neuhausen</name><affiliation><nlm:aff id="A167">Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA</nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="A168">Department of Epidemiology, University of California Irvine, Irvine, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Luccarini, Craig" sort="Luccarini, Craig" uniqKey="Luccarini C" first="Craig" last="Luccarini">Craig Luccarini</name><affiliation><nlm:aff id="A5">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Baynes, Caroline" sort="Baynes, Caroline" uniqKey="Baynes C" first="Caroline" last="Baynes">Caroline Baynes</name><affiliation><nlm:aff id="A5">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Ahmed, Shahana" sort="Ahmed, Shahana" uniqKey="Ahmed S" first="Shahana" last="Ahmed">Shahana Ahmed</name><affiliation><nlm:aff id="A5">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Healey, Catherine S" sort="Healey, Catherine S" uniqKey="Healey C" first="Catherine S" last="Healey">Catherine S. Healey</name><affiliation><nlm:aff id="A5">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Tessier, Daniel C" sort="Tessier, Daniel C" uniqKey="Tessier D" first="Daniel C" last="Tessier">Daniel C. Tessier</name><affiliation><nlm:aff id="A169">McGill University and Génome Québec Innovation Centre, Montréal, Québec, Canada</nlm:aff></affiliation></author><author><name sortKey="Vincent, Daniel" sort="Vincent, Daniel" uniqKey="Vincent D" first="Daniel" last="Vincent">Daniel Vincent</name><affiliation><nlm:aff id="A169">McGill University and Génome Québec Innovation Centre, Montréal, Québec, Canada</nlm:aff></affiliation></author><author><name sortKey="Bacot, Francois" sort="Bacot, Francois" uniqKey="Bacot F" first="Francois" last="Bacot">Francois Bacot</name><affiliation><nlm:aff id="A169">McGill University and Génome Québec Innovation Centre, Montréal, Québec, Canada</nlm:aff></affiliation></author><author><name sortKey="Pita, Guillermo" sort="Pita, Guillermo" uniqKey="Pita G" first="Guillermo" last="Pita">Guillermo Pita</name><affiliation><nlm:aff id="A61">Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Alonso, M Rosario" sort="Alonso, M Rosario" uniqKey="Alonso M" first="M Rosario" last="Alonso">M Rosario Alonso</name><affiliation><nlm:aff id="A61">Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Alvarez, Nuria" sort="Alvarez, Nuria" uniqKey="Alvarez N" first="Nuria" last="Álvarez">Nuria Álvarez</name><affiliation><nlm:aff id="A61">Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Herrero, Daniel" sort="Herrero, Daniel" uniqKey="Herrero D" first="Daniel" last="Herrero">Daniel Herrero</name><affiliation><nlm:aff id="A61">Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="A134">Centre Hospitalier Universitaire de Québec Research Center, Quebec City, Quebec, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A135">Laval University, Quebec City, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul Pdp" sort="Pharoah, Paul Pdp" uniqKey="Pharoah P" first="Paul Pdp" last="Pharoah">Paul Pdp Pharoah</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="A3">Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M" last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="A5">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="A2">Department of Genetics, QIMR (Queensland Institute for Medical Research) Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="A6">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F" last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Genome wide association studies (GWAS) and large scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining ~14% of the familial risk of the disease. To identify new susceptibility loci, we performed a meta-analysis of 11 GWAS comprising of 15,748 breast cancer cases and 18,084 controls, and 46,785 cases and 42,892 controls from 41 studies genotyped on a 200K custom array (iCOGS). Analyses were restricted to women of European ancestry. Genotypes for more than 11M SNPs were generated by imputation using the 1000 Genomes Project reference panel. We identified 15 novel loci associated with breast cancer at <italic>P</italic><5×10<sup>−8</sup>. Combining association analysis with ChIP-Seq data in mammary cell lines and ChIA-PET chromatin interaction data in ENCODE, we identified likely target genes in two regions: <italic>SETBP1</italic> on 18q12.3 and <italic>RNF115</italic> and <italic>PDZK1</italic> on 1q21.1. One association appears to be driven by an amino-acid substitution in <italic>EXO1</italic>.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kamangar, F" uniqKey="Kamangar F">F Kamangar</name></author><author><name sortKey="Dores, Gm" uniqKey="Dores G">GM Dores</name></author><author><name sortKey="Anderson, Wf" uniqKey="Anderson W">WF Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Easton, Df" uniqKey="Easton D">DF Easton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hunter, Dj" uniqKey="Hunter D">DJ Hunter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stacey, Sn" uniqKey="Stacey S">SN Stacey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stacey, Sn" uniqKey="Stacey S">SN Stacey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ahmed, S" 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<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9216904</journal-id><journal-id journal-id-type="pubmed-jr-id">2419</journal-id><journal-id journal-id-type="nlm-ta">Nat Genet</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Genet.</journal-id><journal-title-group><journal-title>Nature genetics</journal-title></journal-title-group><issn pub-type="ppub">1061-4036</issn><issn pub-type="epub">1546-1718</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25751625</article-id><article-id pub-id-type="pmc">4549775</article-id><article-id pub-id-type="doi">10.1038/ng.3242</article-id><article-id pub-id-type="manuscript">NIHMS664248</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Michailidou</surname><given-names>Kyriaki</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib 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contrib-type="author"><name><surname>Arndt</surname><given-names>Volker</given-names></name><xref ref-type="aff" rid="A126">127</xref></contrib><contrib contrib-type="author"><name><surname>Stegmaier</surname><given-names>Christa</given-names></name><xref ref-type="aff" rid="A128">129</xref></contrib><contrib contrib-type="author"><name><surname>Ashworth</surname><given-names>Alan</given-names></name><xref ref-type="aff" rid="A12">13</xref></contrib><contrib contrib-type="author"><name><surname>Orr</surname><given-names>Nick</given-names></name><xref ref-type="aff" rid="A12">13</xref></contrib><contrib contrib-type="author"><name><surname>Schoemaker</surname><given-names>Minouk J</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Swerdlow</surname><given-names>Anthony J</given-names></name><xref ref-type="aff" rid="A11">11</xref><xref ref-type="aff" rid="A129">130</xref></contrib><contrib 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contrib-type="author"><name><surname>Jukkola-Vuorinen</surname><given-names>Arja</given-names></name><xref ref-type="aff" rid="A137">138</xref></contrib><contrib contrib-type="author"><name><surname>Grip</surname><given-names>Mervi</given-names></name><xref ref-type="aff" rid="A138">139</xref></contrib><contrib contrib-type="author"><name><surname>Brauch</surname><given-names>Hiltrud</given-names></name><xref ref-type="aff" rid="A127">128</xref><xref ref-type="aff" rid="A139">140</xref><xref ref-type="aff" rid="A140">141</xref><xref ref-type="aff" rid="A141">142</xref></contrib><contrib contrib-type="author"><name><surname>Hamann</surname><given-names>Ute</given-names></name><xref ref-type="aff" rid="A142">143</xref></contrib><contrib contrib-type="author"><name><surname>Brüning</surname><given-names>Thomas</given-names></name><xref ref-type="aff" rid="A143">144</xref></contrib><contrib contrib-type="author"><collab>The GENICA Network</collab><xref rid="FN2" ref-type="author-notes">12</xref></contrib><contrib contrib-type="author"><name><surname>Radice</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="A144">145</xref></contrib><contrib contrib-type="author"><name><surname>Peterlongo</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="A145">146</xref></contrib><contrib contrib-type="author"><name><surname>Manoukian</surname><given-names>Siranoush</given-names></name><xref ref-type="aff" rid="A146">147</xref></contrib><contrib contrib-type="author"><name><surname>Bernard</surname><given-names>Loris</given-names></name><xref ref-type="aff" rid="A147">148</xref><xref ref-type="aff" rid="A148">149</xref></contrib><contrib contrib-type="author"><name><surname>Bogdanova</surname><given-names>Natalia V</given-names></name><xref ref-type="aff" rid="A149">150</xref></contrib><contrib contrib-type="author"><name><surname>Dörk</surname><given-names>Thilo</given-names></name><xref ref-type="aff" rid="A150">151</xref></contrib><contrib contrib-type="author"><name><surname>Mannermaa</surname><given-names>Arto</given-names></name><xref ref-type="aff" rid="A151">152</xref><xref ref-type="aff" rid="A152">153</xref><xref ref-type="aff" rid="A153">154</xref></contrib><contrib contrib-type="author"><name><surname>Kataja</surname><given-names>Vesa</given-names></name><xref ref-type="aff" rid="A154">155</xref><xref ref-type="aff" rid="A155">156</xref></contrib><contrib contrib-type="author"><name><surname>Kosma</surname><given-names>Veli-Matti</given-names></name><xref ref-type="aff" rid="A151">152</xref><xref ref-type="aff" rid="A152">153</xref><xref ref-type="aff" rid="A153">154</xref></contrib><contrib contrib-type="author"><name><surname>Hartikainen</surname><given-names>Jaana M</given-names></name><xref ref-type="aff" rid="A151">152</xref><xref ref-type="aff" rid="A152">153</xref><xref ref-type="aff" rid="A153">154</xref></contrib><contrib contrib-type="author"><name><surname>Devilee</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="A156">157</xref></contrib><contrib contrib-type="author"><name><surname>Tollenaar</surname><given-names>Robert AEM</given-names></name><xref ref-type="aff" rid="A157">158</xref></contrib><contrib contrib-type="author"><name><surname>Seynaeve</surname><given-names>Caroline</given-names></name><xref ref-type="aff" rid="A158">159</xref></contrib><contrib contrib-type="author"><name><surname>Van Asperen</surname><given-names>Christi J</given-names></name><xref ref-type="aff" rid="A159">160</xref></contrib><contrib contrib-type="author"><name><surname>Jakubowska</surname><given-names>Anna</given-names></name><xref ref-type="aff" rid="A160">161</xref></contrib><contrib contrib-type="author"><name><surname>Lubinski</surname><given-names>Jan</given-names></name><xref ref-type="aff" rid="A160">161</xref></contrib><contrib contrib-type="author"><name><surname>Jaworska</surname><given-names>Katarzyna</given-names></name><xref ref-type="aff" rid="A160">161</xref></contrib><contrib contrib-type="author"><name><surname>Huzarski</surname><given-names>Tomasz</given-names></name><xref ref-type="aff" rid="A160">161</xref></contrib><contrib contrib-type="author"><name><surname>Sangrajrang</surname><given-names>Suleeporn</given-names></name><xref ref-type="aff" rid="A161">162</xref></contrib><contrib contrib-type="author"><name><surname>Gaborieau</surname><given-names>Valerie</given-names></name><xref ref-type="aff" rid="A162">163</xref></contrib><contrib contrib-type="author"><name><surname>Brennan</surname><given-names>Paul</given-names></name><xref ref-type="aff" rid="A162">163</xref></contrib><contrib contrib-type="author"><name><surname>McKay</surname><given-names>James</given-names></name><xref ref-type="aff" rid="A162">163</xref></contrib><contrib contrib-type="author"><name><surname>Slager</surname><given-names>Susan</given-names></name><xref ref-type="aff" rid="A43">44</xref></contrib><contrib contrib-type="author"><name><surname>Toland</surname><given-names>Amanda E</given-names></name><xref ref-type="aff" rid="A163">164</xref></contrib><contrib contrib-type="author"><name><surname>Ambrosone</surname><given-names>Christine B</given-names></name><xref ref-type="aff" rid="A164">165</xref></contrib><contrib contrib-type="author"><name><surname>Yannoukakos</surname><given-names>Drakoulis</given-names></name><xref ref-type="aff" rid="A165">166</xref></contrib><contrib contrib-type="author"><name><surname>Kabisch</surname><given-names>Maria</given-names></name><xref ref-type="aff" rid="A142">143</xref></contrib><contrib contrib-type="author"><name><surname>Torres</surname><given-names>Diana</given-names></name><xref ref-type="aff" rid="A142">143</xref><xref ref-type="aff" rid="A166">167</xref></contrib><contrib contrib-type="author"><name><surname>Neuhausen</surname><given-names>Susan L</given-names></name><xref ref-type="aff" rid="A167">168</xref></contrib><contrib contrib-type="author"><name><surname>Anton-Culver</surname><given-names>Hoda</given-names></name><xref ref-type="aff" rid="A168">169</xref></contrib><contrib contrib-type="author"><name><surname>Luccarini</surname><given-names>Craig</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Baynes</surname><given-names>Caroline</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Ahmed</surname><given-names>Shahana</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Healey</surname><given-names>Catherine S</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Tessier</surname><given-names>Daniel C</given-names></name><xref ref-type="aff" rid="A169">170</xref></contrib><contrib contrib-type="author"><name><surname>Vincent</surname><given-names>Daniel</given-names></name><xref ref-type="aff" rid="A169">170</xref></contrib><contrib contrib-type="author"><name><surname>Bacot</surname><given-names>Francois</given-names></name><xref ref-type="aff" rid="A169">170</xref></contrib><contrib contrib-type="author"><name><surname>Pita</surname><given-names>Guillermo</given-names></name><xref ref-type="aff" rid="A61">62</xref></contrib><contrib contrib-type="author"><name><surname>Alonso</surname><given-names>M Rosario</given-names></name><xref ref-type="aff" rid="A61">62</xref></contrib><contrib contrib-type="author"><name><surname>Álvarez</surname><given-names>Nuria</given-names></name><xref ref-type="aff" rid="A61">62</xref></contrib><contrib contrib-type="author"><name><surname>Herrero</surname><given-names>Daniel</given-names></name><xref ref-type="aff" rid="A61">62</xref></contrib><contrib contrib-type="author"><name><surname>Simard</surname><given-names>Jacques</given-names></name><xref ref-type="aff" rid="A134">135</xref><xref ref-type="aff" rid="A135">136</xref></contrib><contrib contrib-type="author"><name><surname>Pharoah</surname><given-names>Paul PDP</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Kraft</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Dunning</surname><given-names>Alison M</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Chenevix-Trench</surname><given-names>Georgia</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Hall</surname><given-names>Per</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas F</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A5">5</xref></contrib></contrib-group><aff id="A1"><label>1</label>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</aff><aff id="A2"><label>2</label>Department of Genetics, QIMR (Queensland Institute for Medical Research) Berghofer Medical Research Institute, Brisbane, Queensland, Australia</aff><aff id="A3"><label>3</label>Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, MA, USA</aff><aff id="A4"><label>4</label>Division of Molecular Carcinogenesis, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands</aff><aff id="A5"><label>5</label>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</aff><aff id="A6"><label>6</label>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A7"><label>7</label>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</aff><aff id="A8"><label>8</label>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</aff><aff id="A9"><label>9</label>Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</aff><aff id="A10"><label>10</label>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</aff><aff id="A11"><label>11</label>Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</aff><aff id="A12"><label>13</label>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK</aff><aff id="A13"><label>14</label>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</aff><aff id="A14"><label>15</label>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A15"><label>16</label>Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Hamburg, Germany</aff><aff id="A16"><label>17</label>Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</aff><aff id="A17"><label>18</label>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</aff><aff id="A18"><label>19</label>Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland</aff><aff id="A19"><label>20</label>Department of Oncology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</aff><aff id="A20"><label>21</label>Center for Cancer Epidemiology and Prevention, University of Chicago, Chicago, Illinois</aff><aff id="A21"><label>22</label>Department of Health Studies, University of Chicago, Chicago, Illinois</aff><aff id="A22"><label>23</label>Department of Medicine, University of Chicago, Chicago, Illinois</aff><aff id="A23"><label>24</label>Department of Human Genetics, University of Chicago, Chicago, Illinois</aff><aff id="A24"><label>25</label>Comprehensive Cancer Center, University of Chicago, Chicago, Illinois</aff><aff id="A25"><label>26</label>Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA, USA</aff><aff id="A26"><label>27</label>Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA</aff><aff id="A27"><label>28</label>Department of Epidemiology, Cancer Prevention Institute of California, Fremont, CA, USA</aff><aff id="A28"><label>29</label>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington</aff><aff id="A29"><label>30</label>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina</aff><aff id="A30"><label>31</label>Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York</aff><aff id="A31"><label>32</label>Norway Cancer Registry, Norway</aff><aff id="A32"><label>33</label>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, Melbourne, Australia</aff><aff id="A33"><label>34</label>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</aff><aff id="A34"><label>35</label>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</aff><aff id="A35"><label>36</label>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA</aff><aff id="A36"><label>37</label>Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Medicine, Baltimore, MD, USA</aff><aff id="A37"><label>38</label>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</aff><aff id="A38"><label>39</label>Vesalius Research Center, VIB, Leuven, Belgium</aff><aff id="A39"><label>40</label>Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</aff><aff id="A40"><label>41</label>Multidisciplinary Breast Center, University Hospitals Leuven, Leuven, Belgium</aff><aff id="A41"><label>42</label>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</aff><aff id="A42"><label>43</label>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA</aff><aff id="A43"><label>44</label>Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</aff><aff id="A44"><label>45</label>Department of Clinical Genetics, VU University Medical Center, section Oncogenetics, Amsterdam, The Netherlands</aff><aff id="A45"><label>46</label>Division of Biomedical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</aff><aff id="A46"><label>47</label>Human Genetics Division, Genome Institute of Singapore, Singapore</aff><aff id="A47"><label>48</label>Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea</aff><aff id="A48"><label>49</label>Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea</aff><aff id="A49"><label>50</label>Cancer Research Institute, Seoul National University, Seoul, Korea</aff><aff id="A50"><label>51</label>Seoul National University College of Medicine, Seoul, Korea</aff><aff id="A51"><label>52</label>Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan</aff><aff id="A52"><label>53</label>Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan</aff><aff id="A53"><label>54</label>Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan</aff><aff id="A54"><label>55</label>Epidemiology Center for Disease Control and Prevention, Mie University Hospital, Tsu, Mie, Japan</aff><aff id="A55"><label>56</label>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 94807 Villejuif, France</aff><aff id="A56"><label>57</label>University Paris-Sud, UMRS 1018, 94807 Villejuif, France</aff><aff id="A57"><label>58</label>Université Paris Sorbonne Cité, UMR-S775 Inserm, Paris, France</aff><aff id="A58"><label>59</label>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</aff><aff id="A59"><label>60</label>Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A60"><label>61</label>National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</aff><aff id="A61"><label>62</label>Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</aff><aff id="A62"><label>63</label>Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia, Spain</aff><aff id="A63"><label>64</label>Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid, Spain</aff><aff id="A64"><label>65</label>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain</aff><aff id="A65"><label>66</label>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</aff><aff id="A66"><label>67</label>Shanghai Center for Disease Control and Prevention, Changning, Shanghai, China</aff><aff id="A67"><label>68</label>Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China</aff><aff id="A68"><label>69</label>Sheffield Cancer Research Centre, University of Sheffield, Sheffield, UK</aff><aff id="A69"><label>70</label>Department of Oncology, University of Sheffield, Sheffield, UK</aff><aff id="A70"><label>71</label>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK</aff><aff id="A71"><label>72</label>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada</aff><aff id="A72"><label>73</label>Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada</aff><aff id="A73"><label>74</label>Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada</aff><aff id="A74"><label>75</label>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada</aff><aff id="A75"><label>76</label>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada</aff><aff id="A76"><label>77</label>Laboratory Medicine Program, University Health Network, Toronto, ON, Canada</aff><aff id="A77"><label>78</label>Research Oncology, Division of Cancer Studies, King’s College London, Guy’s Hospital, London, UK</aff><aff id="A78"><label>79</label>Wellcome Trust Centre for Human Genetics, University of Oxford, UK</aff><aff id="A79"><label>80</label>Oxford Biomedical Research Centre, University of Oxford, UK</aff><aff id="A80"><label>81</label>Surgery, School of Medicine, National University of Ireland, Galway</aff><aff id="A81"><label>82</label>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A82"><label>83</label>Department of Oncology - Pathology, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A83"><label>84</label>Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia</aff><aff id="A84"><label>85</label>Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia</aff><aff id="A85"><label>86</label>Department of Medical Oncology, Erasmus MC Cancer Institute, 3008 AE Rotterdam, The Netherlands</aff><aff id="A86"><label>87</label>Department of Clinical Genetics, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands</aff><aff id="A87"><label>88</label>International Epidemiology Institute, Rockville, MD, USA</aff><aff id="A88"><label>89</label>Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</aff><aff id="A89"><label>90</label>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia</aff><aff id="A90"><label>91</label>Department of Pathology, The University of Melbourne, Melbourne, Australia</aff><aff id="A91"><label>92</label>Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</aff><aff id="A92"><label>93</label>Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</aff><aff id="A93"><label>94</label>School of Public Health, China Medical University, Taichung, Taiwan</aff><aff id="A94"><label>95</label>Cancer Center, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan</aff><aff id="A95"><label>96</label>Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan</aff><aff id="A96"><label>97</label>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</aff><aff id="A97"><label>98</label>Institute of Clinical Medicine, University of Oslo (UiO), Oslo, Norway</aff><aff id="A98"><label>99</label>Department of Clinical Molecular Biology (EpiGen), University of Oslo (UiO), Oslo, Norway</aff><aff id="A99"><label>100</label>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia</aff><aff id="A100"><label>101</label>Anatomical Pathology, The Alfred Hospital, Melbourne, VIC, Australia</aff><aff id="A101"><label>102</label>Genomic Epidemiology Group, German Cancer Research Center (Deutsches Krebsforschungszentrum; DKFZ), Heidelberg, Germany</aff><aff id="A102"><label>103</label>Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece; Hellenic Health Foundation, Athens, Greece</aff><aff id="A103"><label>104</label>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands</aff><aff id="A104"><label>105</label>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK</aff><aff id="A105"><label>106</label>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø - The Arctic University of Norway, Tromsø, Norway</aff><aff id="A106"><label>107</label>Department of Surgical and Perioperative Sciences, Umea University, Sweden</aff><aff id="A107"><label>108</label>School of Clinical Medicine, Cambridge Institute of Public Health, University of Cambridge, UK</aff><aff id="A108"><label>109</label>Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute, ISPO, Florence, Italy</aff><aff id="A109"><label>110</label>Section for Epidemiology, Aarhus University, Aarhus, Denmark</aff><aff id="A110"><label>111</label>Inserm Centre for research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women’s Health team, Villejuif, France</aff><aff id="A111"><label>112</label>Univ Paris Sud, Villejuif, France</aff><aff id="A112"><label>113</label>Department of Epidemiology, Consejeria de Sanidad y Politica Social, CIBER de Epidemiologia y Salud Publica, Murcia, Spain</aff><aff id="A113"><label>114</label>Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany</aff><aff id="A114"><label>115</label>Center for Hereditary Breast and Ovarian Cancer, University Hospital Cologne, Cologne, Germany</aff><aff id="A115"><label>116</label>Center for Integrated Oncology (CIO), University Hospital Cologne, Cologne, Germany</aff><aff id="A116"><label>117</label>Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine, University of Cologne, Cologne, Germany</aff><aff id="A117"><label>118</label>Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany</aff><aff id="A118"><label>119</label>Division of Health Sciences, Warwick Medical school, Warwick University, Coventry, UK</aff><aff id="A119"><label>120</label>Institute of Population Health, University of Manchester, Manchester, UK</aff><aff id="A120"><label>121</label>Ministry of Public Health, Nonthaburi, Thailand</aff><aff id="A121"><label>122</label>Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore</aff><aff id="A122"><label>123</label>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore</aff><aff id="A123"><label>124</label>Division of General Surgery, National University Health System</aff><aff id="A124"><label>125</label>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany</aff><aff id="A125"><label>126</label>University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, Los Angeles, CA, USA</aff><aff id="A126"><label>127</label>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A127"><label>128</label>German Cancer Consortium (DKTK), Heidelberg, Germany</aff><aff id="A128"><label>129</label>Saarland Cancer Registry, Saarbrücken, Germany</aff><aff id="A129"><label>130</label>Division of Breast Cancer Research, Institute of Cancer Research, London, UK</aff><aff id="A130"><label>131</label>Department of Medicine, McGill University, Montreal, QC, Canada</aff><aff id="A131"><label>132</label>Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, Montreal, QC, Canada</aff><aff id="A132"><label>133</label>Département de Santé environnementale et santé au travail, École de santé publique, Université de Montréal, Montreal, Quebec, Canada</aff><aff id="A133"><label>134</label>Département de Médecine sociale et préventive, École de santé publique, Université de Montréal, Montreal, Quebec, Canada</aff><aff id="A134"><label>135</label>Centre Hospitalier Universitaire de Québec Research Center, Quebec City, Quebec, Canada</aff><aff id="A135"><label>136</label>Laval University, Quebec City, Quebec, Canada</aff><aff id="A136"><label>137</label>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu/Oulu University Hospital, Oulu, Finland</aff><aff id="A137"><label>138</label>Department of Oncology, Oulu University Hospital, University of Oulu, Oulu, Finland</aff><aff id="A138"><label>139</label>Department of Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland</aff><aff id="A139"><label>140</label>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</aff><aff id="A140"><label>141</label>University of Tübingen, Tübingen, Germany</aff><aff id="A141"><label>142</label>German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A142"><label>143</label>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A143"><label>144</label>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany</aff><aff id="A144"><label>145</label>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Milan, Italy</aff><aff id="A145"><label>146</label>Fondazione Istituto FIRC (Italian Foundation for Cancer Research) di Oncologia Molecolare (IFOM), Milan, Italy</aff><aff id="A146"><label>147</label>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Milan, Italy</aff><aff id="A147"><label>148</label>Department of Experimental Oncology, Istituto Europeo di Oncologia, Milan, Italy</aff><aff id="A148"><label>149</label>Cogentech Cancer Genetic Test Laboratory, Milan, Italy</aff><aff id="A149"><label>150</label>Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</aff><aff id="A150"><label>151</label>Gynaecology Research Unit, Hannover Medical School, Hannover, Germany</aff><aff id="A151"><label>152</label>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</aff><aff id="A152"><label>153</label>Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</aff><aff id="A153"><label>154</label>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</aff><aff id="A154"><label>155</label>Cancer Center, Kuopio University Hospital, Kuopio, Finland</aff><aff id="A155"><label>156</label>Central Finland Hospital District, Jyväskylä Central Hospital, Jyväskylä, Finland</aff><aff id="A156"><label>157</label>Department of Human Genetics and Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands</aff><aff id="A157"><label>158</label>Department of Surgical Oncology, Leiden University Medical Center, Leiden, The Netherlands</aff><aff id="A158"><label>159</label>Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands</aff><aff id="A159"><label>160</label>Department of Clinical Genetics, Leiden University Medical Center Leiden, The Netherlands</aff><aff id="A160"><label>161</label>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</aff><aff id="A161"><label>162</label>National Cancer Institute, Bangkok, Thailand</aff><aff id="A162"><label>163</label>International Agency for Research on Cancer, Lyon, France</aff><aff id="A163"><label>164</label>Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH, USA</aff><aff id="A164"><label>165</label>Roswell Park Cancer Institute, Buffalo, NY, USA</aff><aff id="A165"><label>166</label>Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research “Demokritos”, Aghia Paraskevi Attikis, Athens, Greece</aff><aff id="A166"><label>167</label>Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota, Colombia</aff><aff id="A167"><label>168</label>Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA</aff><aff id="A168"><label>169</label>Department of Epidemiology, University of California Irvine, Irvine, CA, USA</aff><aff id="A169"><label>170</label>McGill University and Génome Québec Innovation Centre, Montréal, Québec, Canada</aff><author-notes><corresp id="FN1">Correspondence should be addressed to D.F.E. (<email>dfe20@medschl.cam.ac.uk</email>)</corresp><fn id="FN2"><label>12</label><p>A full list of members and affiliations appears in the <xref rid="SD1" ref-type="supplementary-material">Supplementary Note</xref></p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>13</day><month>8</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>09</day><month>3</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>4</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>10</month><year>2015</year></pub-date><volume>47</volume><issue>4</issue><fpage>373</fpage><lpage>380</lpage><pmc-comment>elocation-id from pubmed: 10.1038/ng.3242</pmc-comment>
<permissions><license xlink:href="http://www.nature.com/authors/editorial_policies/license.html#terms"><license-p>Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:<ext-link ext-link-type="uri" xlink:href="http://www.nature.com/authors/editorial_policies/license.html#terms">http://www.nature.com/authors/editorial_policies/license.html#terms</ext-link></license-p></license></permissions><abstract><p id="P1">Genome wide association studies (GWAS) and large scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining ~14% of the familial risk of the disease. To identify new susceptibility loci, we performed a meta-analysis of 11 GWAS comprising of 15,748 breast cancer cases and 18,084 controls, and 46,785 cases and 42,892 controls from 41 studies genotyped on a 200K custom array (iCOGS). Analyses were restricted to women of European ancestry. Genotypes for more than 11M SNPs were generated by imputation using the 1000 Genomes Project reference panel. We identified 15 novel loci associated with breast cancer at <italic>P</italic><5×10<sup>−8</sup>. Combining association analysis with ChIP-Seq data in mammary cell lines and ChIA-PET chromatin interaction data in ENCODE, we identified likely target genes in two regions: <italic>SETBP1</italic> on 18q12.3 and <italic>RNF115</italic> and <italic>PDZK1</italic> on 1q21.1. One association appears to be driven by an amino-acid substitution in <italic>EXO1</italic>.</p></abstract></article-meta></front><body><p id="P2">Breast cancer is the most common cancer in women worldwide<sup><xref rid="R1" ref-type="bibr">1</xref></sup>. The disease aggregates in families, and has an important inherited component. This inherited component is driven by a combination of rare variants, notably in <italic>BRCA1</italic>, <italic>BRCA2</italic>, <italic>PALB2, ATM</italic> and <italic>CHEK2</italic> conferring a moderate or high lifetime risk of the disease, together with common variants at more than 70 loci, identified through GWAS and large scale replication studies<sup><xref rid="R2" ref-type="bibr">2</xref>–<xref rid="R20" ref-type="bibr">20</xref></sup>. Taken together, these loci explain approximately one-third of the excess familial risk of breast cancer.</p><p id="P3">The majority of susceptibility SNPs has been identified through the Breast Cancer Association Consortium (BCAC), a collaboration involving more than 50 case-control studies. We recently reported the results of a large-scale genotyping experiment within BCAC, which utilised a custom array (iCOGS) designed to study variants of interest for breast, ovarian and prostate cancers. iCOGS comprised more than 200,000 variants, of which 29,807 had been selected from combined analysis of nine breast cancer GWAS involving 10,052 breast cancer cases and 12,575 controls of European ancestry. In total, 45,290 breast cancer cases and 41,880 controls of European ancestry from 41 studies were genotyped with iCOGS, leading to the discovery of 41 novel susceptibility loci<sup><xref rid="R16" ref-type="bibr">16</xref></sup>. A parallel analysis identified four loci specific to oestrogen receptor (ER)-negative disease<sup><xref rid="R17" ref-type="bibr">17</xref></sup>. However, additional susceptibility loci may have been missed because they were not selected from the original GWAS, or not included on the array.</p><p id="P4">Genotype imputation is a powerful approach to infer missing genotypes using the genetic correlations defined in a densely genotyped reference panel, thus providing the opportunity to identify novel susceptibility variants even if not directly genotyped<sup><xref rid="R21" ref-type="bibr">21</xref></sup>. In this analysis we aimed to identify additional breast cancer susceptibility loci by utilising data from all 200k variants on the iCOGS array, and used imputation to estimate genotypes for more than 11M SNPs. We applied the same approach to data from 11 GWAS. After quality control (QC) exclusions, the dataset comprised 15,748 breast cancer cases and 18,084 controls from GWAS, and 46,785 cases and 42,892 controls from 41 studies genotyped with iCOGS (see Online Methods and <xref rid="SD2" ref-type="supplementary-material">Supplementary Tables 1a–1e</xref>). All subjects were women of European ancestry.</p><p id="P5">We imputed genotypes using the 1000 Genomes Project March 2012 release as the reference dataset (see Online Methods) The main analyses were based on ~11.6M SNPs that were imputed with imputation r<sup>2</sup> >0.3 and had MAF>0.005 in at least one of the datasets<sup><xref rid="R22" ref-type="bibr">22</xref></sup>.</p><p id="P6">Of common SNPs (MAF>0.05), 88% were imputed from the iCOGS array with r<sup>2</sup>>0.5; this compared to 99% of variants for the largest GWAS (UK2), which was genotyped using a 670k SNP array (<xref rid="F1" ref-type="fig">Figure 1a and 1b</xref>, <xref rid="SD2" ref-type="supplementary-material">Supplementary Table 2</xref>). Thirty-seven per cent of common SNPs were imputed on the iCOGS with r<sup>2</sup>>0.9, compared with 85% for UK2. Thus, despite being designed as a follow-up of GWAS for different diseases rather than a genome-wide array, the majority of common variants could be imputed using the iCOGS, but the overall imputation quality was, poorer that from a standard GWAS array. Imputation quality decreased with decreasing allele frequency (<xref rid="F1" ref-type="fig">Figure 1c and 1d</xref>, <xref rid="SD2" ref-type="supplementary-material">Supplementary Table 2</xref>).</p><p id="P7">Log odds ratio estimates and standard errors were calculated for each dataset using logistic regression, adjusting for principal components where it was found to reduce substantially the inflation factor. We then combined the results from each dataset for variants with MAF >0.5% using a fixed effects meta-analysis<sup><xref rid="R23" ref-type="bibr">23</xref></sup>. More than 7,000 variants with a combined <italic>P</italic><5×10<sup>−8</sup> for association were identified, the large majority of which was in regions previously shown to be associated with breast cancer susceptibility. Of the 79 previously published breast cancer susceptibility loci identified in women of European ancestry, all but eight show evidence of association at P<5×10<sup>−8</sup> for overall, ER-positive or ER-negative disease risk (<xref rid="SD2" ref-type="supplementary-material">Supplementary Tables 3a, 3b and 3c</xref>). For four of the eight variants, (rs1550623 on 2q31, rs11571833 on 13q13.1, rs12422552 on 12p13.1 and rs11242674 on 6p25.3), slightly weaker evidence of association was observed. One reported variant, rs7726159 did not reach P<5×10<sup>−8</sup> in this (<italic>P</italic>=0.0017) or the previous analysis – it was identified through fine-mapping of the <italic>TERT</italic> region on 5p15.33<sup><xref rid="R18" ref-type="bibr">18</xref></sup>. One other variant in <italic>AKAP9,</italic> rs6964587 reported previously<sup><xref rid="R19" ref-type="bibr">19</xref></sup> did not reach P<5×10<sup>−8</sup> but an alternative correlated with it did (P=3.67×10<sup>−8</sup> for chr7:91681597:D; r<sup>2</sup> between the two markers = 0.98). The two remaining variants (rs2380205 on 10p15 and rs1045485 at <italic>CASP8</italic>) were reported in earlier analysis<sup><xref rid="R9" ref-type="bibr">9</xref>,<xref rid="R24" ref-type="bibr">24</xref></sup> but did not even reach <italic>P</italic><0.0001, suggesting that they may have been false positive reports. An alternative variant at <italic>CASP8</italic>, rs1830298 (r<sup>2</sup>=0.06, D’=1 with rs1045485 in 1000G CEU) did reach P<5×10<sup>−8</sup> in this dataset<sup><xref rid="R25" ref-type="bibr">25</xref></sup>.</p><p id="P8">To assess evidence for additional susceptibility loci, we removed all SNPs within 500kb of susceptibility variants identified previously in women of European ancestry<sup><xref rid="R2" ref-type="bibr">2</xref>–<xref rid="R14" ref-type="bibr">14</xref>,<xref rid="R16" ref-type="bibr">16</xref>–<xref rid="R19" ref-type="bibr">19</xref></sup>, leaving 314 variants from 27 regions associated with breast cancer at <italic>P</italic><5×10<sup>−8</sup> (<xref rid="SD1" ref-type="supplementary-material">Supplementary Figures 1 and 2</xref>). The strongest associations were observed in a 610kb (b37 28,314,612- 28,928,858) interval on chromosome 22 (smallest <italic>P</italic>=8.2×10<sup>−22</sup>, for rs62237573). This interval lies approximately 100kb centromeric to <italic>CHEK2</italic>, and further analysis revealed that the associated SNPs were correlated with the <italic>CHEK2</italic> founder variant 1100delC (strongest correlation r<sup>2</sup>=0.39 for SNP rs62235635), <italic>CHEK2</italic> 1100delC is known to be associated with breast cancer through candidate gene analysis, but has not previously generated an association in GWAS <sup><xref rid="R26" ref-type="bibr">26</xref>,<xref rid="R27" ref-type="bibr">27</xref></sup>. We performed an analysis adjusting for <italic>CHEK2</italic> 1100delC using data on ~40,000 samples that had been genotyped for this variant. The strongest associated variant in this subset was rs140914118; after adjustment for 1100delC the statistical significance diminished markedly (<italic>P</italic>=3.1×10<sup>−9</sup> to <italic>P</italic>=0.78; <xref rid="SD1" ref-type="supplementary-material">Supplementary Figures 3a and 3b</xref>), suggesting that this signal is driven by <italic>CHEK2</italic> 1100delC.</p><p id="P9">Variants in four regions (<italic>DNAJC1</italic>, 5p12, <italic>PTHLH</italic> and <italic>MKL1</italic>) lay within 2Mb of a previously published susceptibility-associated SNP. In each case, these associations became weaker (no longer <italic>P</italic><5×10<sup>−8</sup>) after adjustment for the previously associated SNP(s) in the region (data not shown). For four other regions, the significant variants were identified in just one GWAS, and failed imputation (r<sup>2</sup><0.3) in the remaining datasets, including iCOGS; we did not consider these variants further.</p><p id="P10">To confirm the results for the remaining 18 regions, we performed re-imputation in the iCOGS dataset without phasing (See Online Methods). Fifteen loci remained associated with breast cancer at P<5×10<sup>−8</sup> (<xref rid="T1" ref-type="table">Table 1</xref> and <xref rid="SD2" ref-type="supplementary-material">Supplementary Table 4</xref>). For three of the loci, the most significant SNP, or a highly correlated SNP, had been directly genotyped on iCOGS (<xref rid="SD2" ref-type="supplementary-material">Supplementary Table 5</xref>); one, rs11205277, had been included on the array because it is associated with adult height<sup><xref rid="R28" ref-type="bibr">28</xref></sup>, while the other two were selected based on evidence from the combined breast cancer GWAS but failed to reach genome-wide significance in the earlier analyses. We attempted to genotype the 12 remaining variants on a subset of ~4K samples to confirm the quality of the imputation (10 variants could be directly genotyped, for one region an alternative correlated variant was selected (<xref rid="SD2" ref-type="supplementary-material">Supplementary Table 5</xref>). For the 11 variants that could be assessed, the r<sup>2</sup> between the observed and imputed genotypes were close to the r<sup>2</sup> estimated in the imputation. Furthermore, the estimated effect sizes in the subset of individuals that we genotyped were similar to those obtained from the imputed genotypes (<xref rid="SD2" ref-type="supplementary-material">Supplementary Table 5</xref>). These results indicate that the analyses based on imputed genotype data were reliable.</p><p id="P11">There was little or no evidence of heterogeneity in the per-allele odds ratios (ORs) among studies genotyped using iCOGS (<xref rid="SD2" ref-type="supplementary-material">Supplementary Table 6</xref> and <xref rid="SD1" ref-type="supplementary-material">Supplementary Figure 4</xref>). There was little evidence for departure from a log-additive model for any locus, except for a borderline departure for rs6796502 (<italic>P</italic>=0.049) for which the ORs for heterozygotes and homozygotes for the risk associated allele were similar (<xref rid="SD2" ref-type="supplementary-material">Supplementary Table 6</xref>).</p><p id="P12">The estimated ORs for invasive versus in-situ disease were similar for all the loci (<italic>P</italic>>0.05) (<xref rid="SD2" ref-type="supplementary-material">Supplementary Table 7</xref>). For four of the loci, rs12405132, rs12048493, rs4593472 and rs6507583 the association was stronger for ER positive disease (case only <italic>P</italic><0.05) (<xref rid="SD2" ref-type="supplementary-material">Supplementary Table 8</xref>). Seven of the loci were associated with ER-negative disease (<italic>P</italic><0.05) but none had a stronger association for ER-negative than ER-positive disease. Two of the loci showed significant trends in the OR by age at diagnosis: for rs13162653, the OR was higher at younger ages (<italic>P</italic>=0.007), while for rs6507583, the OR was higher at older ages (<italic>P</italic>=0.006) (<xref rid="SD2" ref-type="supplementary-material">Supplementary Table 9</xref>). One of the variants, chr17:29230520:D in <italic>ATAD5</italic> is correlated with a variant that has also been shown to be associated with serous ovarian cancer in a meta-analysis<sup><xref rid="R29" ref-type="bibr">29</xref></sup> (r<sup>2</sup>=0.93 between chr17:29230520:D and chr17:29181220:I).</p><p id="P13">To approach the task of identifying the likely causal variants and genes underlying these associations, we first defined the set of all SNPs correlated with each of the 15 lead SNPs and that could not be ruled out as potentially causal (based on a likelihood ratio 100:1<sup><xref rid="R30" ref-type="bibr">30</xref></sup>), resulting in a subset of 522 variants (<xref rid="SD2" ref-type="supplementary-material">Supplementary Table 10</xref>). One of the variants, rs72755295, lies in an intron of <italic>EXO1</italic>, encoding a protein involved in mismatch repair. It is strongly correlated with only one other variant, rs4149909, coding for an amino-acid substitution in <italic>EXO1</italic> (p.Asn279Ser; CADD score 33<sup><xref rid="R31" ref-type="bibr">31</xref></sup>), suggesting that this variant is likely to be functionally related to breast cancer risk. None of the remaining SNPs lay within gene coding sequences, consistent with previous observations that most common cancer susceptibility variants are regulatory. For each of the remaining 520 variants, we then looked for enhancer elements in mammary cell lines, based on ENCODE ChIP-Seq data<sup><xref rid="R32" ref-type="bibr">32</xref>,<xref rid="R33" ref-type="bibr">33</xref></sup>. To identify potential gene targets, we combined this information with ENCODE ChIA-PET chromatin interaction data. We identified two regions in which the associated variants overlapped with putative enhancer sequences and for which consistent promoter interactions were predicted (<xref rid="T1" ref-type="table">Table 1</xref>). For rs12405132 at 1q21.1, we identified four potential interacting genes, <italic>RNF115</italic>, <italic>POLR3C</italic>, <italic>PDZK1</italic> and <italic>PIAS3</italic> (<xref rid="F2" ref-type="fig">Figure 2</xref>). Of these, the strongest evidence was for <italic>RNF115</italic> and <italic>PDZK1;</italic> three of the 64 potentially causal variants lay in interacting enhancer regions. <italic>RNF115</italic> (also known as <italic>BCA2</italic>) is an E3 ubiquitin ligase RING finger protein that is overexpressed in ER-positive breast cancers<sup><xref rid="R34" ref-type="bibr">34</xref></sup>. <italic>PDZK1</italic> is a scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains, and has been proposed to act as an oncogene in breast cancer<sup><xref rid="R35" ref-type="bibr">35</xref></sup>.</p><p id="P14">SNPs correlated with rs6507583 at 18q12.3 lay in regions interacting with the promoter of <italic>SETBP1</italic> (<xref rid="SD1" ref-type="supplementary-material">Supplementary Figure 5</xref>). The encoded protein has been shown to bind the SET nuclear oncogene which is involved in DNA replication.</p><p id="P15">We utilised data from TCGA to assess associations between the 15 novel susceptibility variants and expression of neighbouring genes in breast tumors and normal breast tissue. One SNP, rs7707921, was strongly associated with <italic>RPS23</italic> expression in all tissues (<xref rid="SD2" ref-type="supplementary-material">Supplementary Table 11</xref>, <xref rid="SD1" ref-type="supplementary-material">Supplementary Figure 6</xref>). However, stronger associations with expression were observed with more telomeric SNPs that were less strongly associated with disease risk (top eQTL SNP rs3739: <italic>P</italic>=10<sup>−23</sup>, <italic>P</italic>-risk=5.28×10<sup>−7</sup>), suggesting that this association may be coincidental. SNP, rs7707921 was also more weakly associated with expression of <italic>ATP6AP1L</italic> (<italic>P</italic>=5.6×10<sup>−5</sup> in tumours, <italic>P</italic>=0.066 in normal tissue).</p><p id="P16">Based on the estimated ORs in the iCOGS stage (all but one of which were in the range 1.05–1.10), the 15 novel loci identified here would explain a further ~2% of the 2-fold familial risk of breast cancer. Taken together with previously identified loci, more than 90 independent common susceptibility loci for breast cancer have been identified, explaining ~16% of the familial risk. We estimate assuming a log-additive model that, based on genotypes for variants at these loci, approximately 5% of women in the general population have a >2 fold increased risk of breast cancer and 0.7% of women have a >3 fold increased risk. In the current analyses, more than 50% of variants with MAF>0.005 in subjects of European ancestry were well imputable (r<sup>2</sup>>0.5) These results suggest that, while there may be further susceptibility variants with comparable associated effects that were not well imputed, the identification of many additional loci will require larger association studies. In the meantime, inclusion of these additional loci in polygenic risk scores will improve our ability to discriminate between high and low risk individuals, potentially improving breast cancer screening and prevention.</p><sec id="S1" specific-use="web-only"><title>Online Methods</title><p id="P17">Details of the subjects, genotyping and QC measures for the GWAS and iCOGS data are described elsewhere<sup><xref rid="R12" ref-type="bibr">12</xref>,<xref rid="R14" ref-type="bibr">14</xref>,<xref rid="R16" ref-type="bibr">16</xref>,<xref rid="R36" ref-type="bibr">36</xref>,<xref rid="R37" ref-type="bibr">37</xref></sup>. All participating studies were approved by their appropriate ethics review board and all subjects provided informed consent. Analyses were restricted to women of European ancestry. All imputations were performed using the 1000 Genomes Project March 2012 release as the reference panel. Of the 11 GWAS, 8 (C-BCAC) plus a subset of the BPC3 GWAS (CGEMS) were used in the combined GWAS analysis that nominated 29,807 SNPs for the array. The BPC3 and TNBCC GWAS nominated additional SNPs with evidence for association with ER-negative or triple-negative (ER-, PR- and HER2- negative) breast cancer. The EBCG GWAS was not used to nominate SNPs for the iCOGS array.</p><p id="P18">For eight GWAS (C-BCAC), genotypes were imputed in a two-stage procedure, using SHAPEIT to derive phased genotypes and IMPUTEv2 to perform the imputation on the phased data <sup><xref rid="R22" ref-type="bibr">22</xref></sup>. We performed the imputation using 5Mb non-overlapping intervals for the whole genome. OR estimates and standard errors where obtained using logistic regression with SNPTEST <sup><xref rid="R21" ref-type="bibr">21</xref></sup>. For two of the studies we adjusted for the 3 leading principal components as it was found to reduce materially the inflation factor; for the rest of the studies no such adjustment was necessary. For the remaining three GWAS (BPC3, TNBCC and EBCG), imputation was performed using MACH and Minimac<sup><xref rid="R23" ref-type="bibr">23</xref></sup>. Genomic control adjustment was applied to each GWAS as previously described<sup><xref rid="R16" ref-type="bibr">16</xref></sup>. The iCOGS data were also imputed in a two-stage procedure using SHAPEIT and IMPUTEv2, again using 5Mb non-overlapping intervals. We split the ~90K samples into 10 subsets, where possible keeping subjects from the same study in the same subset. We obtained OR estimates and standard errors using logistic regression adjusting for study and 9 principal components.</p><p id="P19">For the regions showing evidence of association we repeated the imputation in iCOGS, using IMPUTEv2 but without pre-phasing in SHAPEIT to improve imputation accuracy. We also increased the number of MCMC iterations from 30 to 90, and increased the buffer region from 250kb to 500kb.</p><sec id="S2"><title>Meta-analysis</title><p id="P20">OR estimates and standard errors were combined in a fixed effects inverse variance meta-analysis using METAL<sup><xref rid="R23" ref-type="bibr">23</xref></sup>. For the GWAS, results were included in the analysis for all SNPs with MAF>0.01 and imputation r<sup>2</sup>>0.3, except for the TN GWAS where the criteria were r<sup>2</sup>>0.9 and MAF>0.05. For iCOGS, we included all SNPs with r<sup>2</sup>>=0.3 and MAF>0.005.</p></sec><sec id="S3"><title>Confirmatory genotyping</title><p id="P21">The best variant in each region after the re-imputation and meta-analysis was genotyped in 4123 samples from SEARCH, using Taqman according to the manufacturer’s instructions. The squared correlations between the observed genotypes and the genotypes estimated by imputation are shown in <xref rid="SD1" ref-type="supplementary-material">Supplementary Table 5</xref>. For all the imputed SNPs the squared correlations was greater than 0.7, the call-rates were >=0.98 and there was no evidence of departure of genotype frequencies from those expected under HWE (p>0.1).</p></sec><sec id="S4"><title>eQTL analyses</title><p id="P22">Germline genotype, mRNA expression, and somatic copy number data for samples taken from breast tumours and tumour-adjacent normal tissue were obtained from The Cancer Genome Atlas<sup><xref rid="R38" ref-type="bibr">38</xref></sup>. The copy number and genotype data were measured using the Affymetrix Genome-Wide Human SNP 6.0 platform. For the mRNA expression data, we used the expression profiles obtained using the Agilent G4502A-07-3 microarray. The genotype data were subjected to the following quality control filters. SNPs were excluded in case of low frequency (MAF < 1%), low call rate (< 95%,) or departure from Hardy-Weinberg equilibrium at P < 1 × 10<sup>13</sup>. Individuals were excluded based on low call rate (< 95%), or high heterozygosity (false discovery rate < 1%). Furthermore, individuals were also excluded in case of non-European ancestry, or male gender. Quality control and intersection with the other genomic data types resulted in 380 tumour samples and 56 normal samples.</p><p id="P23">The genotype data were imputed as described above. eQTL analysis was performed using linear regression with SNPTEST, regressing the mRNA expression of selected candidate genes on the imputed genotype. For each gene, we performed the eQTL analysis against every microarray probe that uniquely maps to that gene. We adjusted the analyses for somatic copy number of the gene, and for SNPs that intersect the probe sequence, provided that their MAF exceeds 1% in individuals of European ancestry in the 1,000 Genomes data.</p></sec><sec id="S5"><title>Enhancer analyses</title><p id="P24">Maps of enhancer regions with predicted target genes were obtained from Hnisz et al.<sup><xref rid="R33" ref-type="bibr">33</xref></sup>, and Corradin et al.<sup><xref rid="R32" ref-type="bibr">32</xref></sup>. Enhancers active in the mammary cell types MCF7, HMEC and HCC1954 were intersected with candidate causal variants using Galaxy. ENCODE ChIA-PET chromatin interaction data from MCF7 cells (mediated by RNApolII and ERα) were downloaded using the UCSC Table browser. Galaxy was used to identify ChIA-PET interactions between an implicated mammary cell enhancer (containing a strongly associated variant) and a predicted gene promoter (defined as regions 3 kb upstream and 1 kb downstream of the transcription start site).</p></sec></sec><sec sec-type="supplementary-material" id="S6"><title>Supplementary Material</title><supplementary-material content-type="local-data" id="SD1"><label>1</label><media xlink:href="NIHMS664248-supplement-1.pdf" orientation="portrait" xlink:type="simple" id="d37e3469" position="anchor"></media></supplementary-material><supplementary-material content-type="local-data" id="SD2"><label>2</label><media xlink:href="NIHMS664248-supplement-2.xlsx" orientation="portrait" xlink:type="simple" id="d37e3473" position="anchor"></media></supplementary-material><supplementary-material content-type="local-data" id="SD3"><label>3</label><media xlink:href="NIHMS664248-supplement-3.xlsx" orientation="portrait" xlink:type="simple" id="d37e3477" position="anchor"></media></supplementary-material></sec></body><back><ack id="S7"><p>The authors wish to thank all the individuals who took part in these studies and all the researchers, clinicians, technicians and administrative staff who have enabled this work to be carried out. BCAC is funded by Cancer Research UK [C1287/A10118, C1287/A12014] and by the European Community’s Seventh Framework Programme under grant agreement n° 223175 (HEALTH-F2-2009-223175) (COGS). Meetings of the BCAC have been funded by the European Union COST programme [BM0606]. Genotyping of the iCOGS array was funded by the European Union (HEALTH-F2-2009-223175), Cancer Research UK (C1287/A10710, C8197/A16565), the Canadian Institutes of Health Research for the “CIHR Team in Familial Risks of Breast Cancer” program, and the Ministry of Economic Development, Innovation and Export Trade of Quebec – grant # PSR-SIIRI-701. Combining the GWAS data was supported in part by The National Institute of Health (NIH) Cancer Post-Cancer GWAS initiative grant: No. 1 U19 CA 148065-01 (DRIVE, part of the GAME-ON initiative). For a full description of funding and acknowledgments, see <xref rid="SD1" ref-type="supplementary-material">Supplementary Note</xref>.</p></ack><fn-group><fn id="FN3" fn-type="conflict"><p><bold>Competing Financial Interests</bold></p><p>The authors confirm that they have no competing financial interests</p></fn><fn id="FN4"><p><bold>URLs</bold></p><p>BCAC <ext-link ext-link-type="uri" xlink:href="http://ccge.medschl.cam.ac.uk/consortia/bcac/index.html">http://ccge.medschl.cam.ac.uk/consortia/bcac/index.html</ext-link></p><p>COGS <ext-link ext-link-type="uri" xlink:href="http://http://www.cogseu.org/">http://http://www.cogseu.org/</ext-link></p><p>ENCODE <ext-link ext-link-type="uri" xlink:href="http://www.genome.gov/encode/">http://www.genome.gov/encode/</ext-link>, <ext-link ext-link-type="uri" xlink:href="genome.ucsc.edu/ENCODE/">genome.ucsc.edu/ENCODE/</ext-link></p><p>iCOGS <ext-link ext-link-type="uri" xlink:href="http://www.nature.com/icogs/">http://www.nature.com/icogs/</ext-link>, <ext-link ext-link-type="uri" xlink:href="http://ccge.medschl.cam.ac.uk/research/consortia/icogs/">http://ccge.medschl.cam.ac.uk/research/consortia/icogs/</ext-link></p><p>IMPUTE <ext-link ext-link-type="uri" xlink:href="http://mathgen.stats.ox.ac.uk/impute/impute.html">http://mathgen.stats.ox.ac.uk/impute/impute.html</ext-link></p><p>MACH <ext-link ext-link-type="uri" xlink:href="http://www.sph.umich.edu/csg/abecasis/MACH/">http://www.sph.umich.edu/csg/abecasis/MACH/</ext-link></p><p>SHAPEIT <ext-link ext-link-type="uri" xlink:href="https://mathgen.stats.ox.ac.uk/genetics_software/shapeit/shapeit.html">https://mathgen.stats.ox.ac.uk/genetics_software/shapeit/shapeit.html</ext-link></p><p>TCGA <ext-link ext-link-type="uri" xlink:href="http://cancergenome.nih.gov/1000">http://cancergenome.nih.gov/1000</ext-link> genomes: <ext-link ext-link-type="uri" xlink:href="http://www.1000genomes.org/">http://www.1000genomes.org/</ext-link></p></fn><fn id="FN5" fn-type="con"><p><bold>Author Contributions</bold></p><p>K. Michailidou and D.F.E. performed the statistical analysis and drafted the manuscript. D.F.E. conceived and coordinated the synthesis of the iCOGS array and led the BCAC. P.H. coordinated the Collaborative Oncological Gene-Environment Study (COGS). J.Benitez led the iCOGS genotyping working group. A.G.-N., G.P., M.R.A., J. Benitez, D.V., F.B., D.C.T., J. Simard, A.M.D., C.L., C. Baynes, S.A, C.S.H and M.J.M. co-ordinated genotyping of the iCOGS array. M.G-C., P.D.P.P. and M.K.S. led the BCAC pathology and survival working group. J.C-C. led the BCAC risk factor working group. A.M.D. and G.C.-T. led the iCOGS quality control working group. J. Beesley, J.D and M.J.L. provided bioinformatics support. M.K.B. and Q. Wang provided data management support for BCAC. S. Canisius provided analysis of the TCGA expression data. J.L.H, M.C.S, H.T. and C.A co-ordinated ABCFS. M.K.S, A.B., S.V and S. Cornelissen co-ordinated ABCS. K. Muir, A. Lophatananon, S.S.-B and P.S. co-ordinated ACP. P.A.F., A.H., M.W.B. and L.H. co-ordinated BBCC. J.P., I.d.S.S., O.F. and L.G. co-ordinated BBCS. E.J.S., I.T., M.J.K. and N.M. co-ordinated BIGGS. P.K, D.J.H., S.L., S.M.G., M.M.G., W.R.D., C.A.H., F.S., B.E.H., L.L.M., C.D.B., S.C, J.F. and R.N.H co-ordinated BPC3. B.B., F.M., H.S. and C. Sohn co-ordinated BSUCH. P.G, T.T, C. Mulot and M. Sanchez co-ordinated CECILE. S.E.B, B.G.N, H.F. and S.F.N. coordinated CGPS. A.G.-N., J. Benitez, M.P.Z. and J.I.A.P co-ordinated CNIO-BCS. H.A-C. and S.L.N. coordinated CTS. H.Brenner, A.K.D., V.A and C. Stegmaier co-ordinated ESTHER. A. Meindl, R.K.S, C. Sutter and R.Y co-ordinated GC-HBOC. H. Brauch, U.H. and T.B. co-ordinated GENICA. H.N., T.A.M, K.A., C.Blomqvist, K.A. and S.K. co-ordinated HEBCS. K. Matsuo, H. Ito, H. Iwata and K.T. co-ordinated HERPACC. T.D. and N.V.B. co-ordinated HMBCS. A. Lindblom and S. Margolin co-ordinated KARBAC. A. Mannermaa, V. Kataja, V-M.K. and J.M.H. co-ordinated KBCP. G.C.-T. and J. Beesley co-ordinated kConFab/AOCS. A.H.W., C-C.T., D.V.D.B and D.O.S co-ordinated LAABC. D.L., P.N., H.W. and E.V.L. coordinated LMBC. J.C-C. D.F-J., U.E., S.B. and A.R. co-ordinated MARIE. P.R., P.P., S. Manoukian and L. Bernard co-ordinated MBCSG. F.J.C., J.E.O., E.H. and C.V. co-ordinated MCBCS. G.G.G., R.L.M. and C. McLean co-ordinated MCCS. C.A.H., B.E.H., F.S. and L.L.M. co-ordinated MEC. J. Simard, M.S.G., F.L. and M.D. co-ordinated MTLGEBCS. S.H.T., C.H.Y., Y.-C.T and N.A.M.T. co-ordinated MYBRCA. V. Kristensen, G.I.G.A., S.N. and A-L.B-D. co-ordinated NBCS. W.Z., S.L.H., M. Shrubsole and J. Long coordinated NBHS. R.W., K.P., A.J-V. and M.G co-ordinated OBCS. I.L.A., J.A.K., G.G. and A.M.M. coordinated OFBCR. P.D., R.A.E.M.T, C. Seynaeve and C.J.V.A. co-ordinated ORIGO. M.G-C., J.F., S.J.C. and L. Brinton co-ordinated PBCS. K.C., H.D., M.E. and J. Brand co-ordinated pKARMA. J.W.M.M. and J.M.C. co-ordinated RBCS. P. Hall, J. Li, J. Liu and K.H. co-ordinated SASBAC. X.-O.S, W.L., Y.-T.G. and H.C. co-ordinated SBCGS. A.C., S.S.C. and M.W.R. Reed co-ordinated SBCS. W.B., L.B.S. and Q.C. coordinated SCCS. M. Shah and B.J.B. co-ordinated SEARCH. D.K., J-Y.C., S.K.P. and K-Y.Y. co-ordinated SEBCS. M.H., H.M., K.S.C. and C.W.C. co-ordinated SGBCC. U.H., M. Kabisch and D. Torres coordinated SKKDKFZS. A.J., J. Lubinski, K.J. and T.H., co-ordinated SZBCS. S. Sangrajrang, V.G., P.B. and J.M. co-ordinated TBCS. F.J.C, S. Slager, A.E.T, C.B.A. and D.Y. co-ordinated the TNBCC. C.-Y.S, C.-N.H., P.-E.W. and M.-F.H. co-ordinated TWBCS. A.S., A.A., N.O. and M.J.S. co-ordinated UKBGS. H.A., M.G.K., A.S.W., E.M.J., K.E.M., M.D.G., R.M.S., G.U., E.M., D.F.S and G.C. co-ordinated EBCG GWAS. Q.W, H.M-H., M.A.A. and R.B.v.d.L co-ordinated DFBBCS GWAS. D.F.E., N.H. and C.T. co-ordinated UK2 GWAS. F.C., D.Trichopoulos, P.P., E.L., M.Sund, K-T.K., M.J.G, D.P., L.D., J-M.H and L.M.M coordinated EPIC. 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for variants with MAF>0.05 <bold>b)</bold> Histogram of the imputation r<sup>2</sup> for the UK2 GWAS for variants with MAF>0.05 <bold>c)</bold> Histogram of the imputation r<sup>2</sup> for the iCOGS for variants with MAF<=0.05 <bold>d)</bold> Histogram of the imputation r<sup>2</sup> for the UK2 GWAS for variants with MAF<=0.05.</p></caption><graphic xlink:href="nihms664248f1"></graphic></fig><fig id="F2" orientation="portrait" position="float"><label>Figure 2</label><caption><p>The chromosome 1 locus tagged by rs12405132 <bold>a)</bold> The Manhattan Plot displays the strength of genetic association (−log<sub>10</sub><italic>P</italic>) versus chromosomal position (Mb), where each dot presents a genotyped (solid black dot) or imputed (red circle) SNP (in the iCOGS stage). The purple horizontal line represents the threshold for genome-wide significance (<italic>P</italic>=5×10<sup>−8</sup>). Gene structures are depicted as well as the location of SNPs with MAF>0.01 which were neither imputed reliably nor genotyped. <bold>b)</bold> Mammary cell enhancer locations as defined in Corradin et al.<sup><xref rid="R32" ref-type="bibr">32</xref></sup>, and Hnisz et al.<sup><xref rid="R33" ref-type="bibr">33</xref></sup>, are shown where elements overlapping the best associated SNPs are labelled with their predicted target genes. A subset of ChiA-PET interactions in MCF7 cells (mediated by either RNApolII or ERa) between enhancers and their target gene promoters are also shown.</p></caption><graphic xlink:href="nihms664248f2"></graphic></fig><table-wrap id="T1" position="float" orientation="landscape"><label>Table 1</label><caption><p>Results for the 15 regions with combined P<5×10<sup>−8</sup>. Results are shown for the strongest associated variant in the region.</p></caption><table frame="box" rules="all"><thead><tr><th valign="top" align="left" rowspan="1" colspan="1">Best variant</th><th valign="top" align="center" rowspan="1" colspan="1">Locus</th><th valign="top" align="right" rowspan="1" colspan="1">Position<xref rid="TFN2" ref-type="table-fn">2</xref></th><th valign="top" align="center" rowspan="1" colspan="1">Alleles<xref rid="TFN3" ref-type="table-fn">3</xref></th><th valign="top" align="center" rowspan="1" colspan="1">EAF<xref rid="TFN4" ref-type="table-fn">4</xref></th><th valign="top" align="center" rowspan="1" colspan="1">r<sup>2</sup><xref rid="TFN5" ref-type="table-fn">5</xref></th><th valign="top" align="center" rowspan="1" colspan="1">GWAS OR<break></break>(95% CI)<xref rid="TFN6" ref-type="table-fn">6</xref></th><th valign="top" align="left" rowspan="1" colspan="1">GWAS P<xref rid="TFN7" ref-type="table-fn">7</xref></th><th valign="top" align="center" rowspan="1" colspan="1">iCOGS OR<break></break>(95% CI)</th><th valign="top" align="left" rowspan="1" colspan="1">iCOGS P</th><th valign="top" align="left" rowspan="1" colspan="1">Combined<break></break>GWAS +<break></break>iCOGS P</th><th valign="top" align="left" rowspan="1" colspan="1">Genes within<break></break>+/−2kb</th><th valign="top" align="left" rowspan="1" colspan="1">Enhancers in<break></break>MCF7/HMEC</th><th valign="top" align="left" rowspan="1" colspan="1">eQTLs</th></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">rs12405132</td><td align="center" valign="top" rowspan="1" colspan="1">1q21.1</td><td align="right" valign="top" rowspan="1" colspan="1">145644984</td><td align="center" valign="top" rowspan="1" colspan="1">C/T</td><td align="center" valign="top" rowspan="1" colspan="1">0.36</td><td align="center" valign="top" rowspan="1" colspan="1">0.96</td><td align="center" valign="top" rowspan="1" colspan="1">0.96 (0.92–0.99)</td><td align="left" valign="top" rowspan="1" colspan="1">0.00962</td><td align="center" valign="top" rowspan="1" colspan="1">0.95 (0.93–0.97)</td><td align="left" valign="top" rowspan="1" colspan="1">2.34×10<sup>−7</sup></td><td align="left" valign="top" rowspan="1" colspan="1">7.92×10<sup>−9</sup></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>LOC10028814, NBPF10, RNF115</italic></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>RNF115</italic>, <italic>POLR3C</italic>,<italic>PDZK1, PIAS3</italic></td><td align="left" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs12048493</td><td align="center" valign="top" rowspan="1" colspan="1">1q21.2</td><td align="right" valign="top" rowspan="1" colspan="1">149927034</td><td align="center" valign="top" rowspan="1" colspan="1">A/C</td><td align="center" valign="top" rowspan="1" colspan="1">0.34</td><td align="center" valign="top" rowspan="1" colspan="1">0.76</td><td align="center" valign="top" rowspan="1" colspan="1">1.04 (0.99–1.09)</td><td align="left" valign="top" rowspan="1" colspan="1">0.121</td><td align="center" valign="top" rowspan="1" colspan="1">1.07 (1.05–1.10)</td><td align="left" valign="top" rowspan="1" colspan="1">1.66×10<sup>−9</sup></td><td align="left" valign="top" rowspan="1" colspan="1">1.10×10<sup>−9</sup></td><td align="left" valign="top" rowspan="1" colspan="1">-</td><td align="left" valign="top" rowspan="1" colspan="1">-</td><td align="left" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs72755295</td><td align="center" valign="top" rowspan="1" colspan="1">1q43</td><td align="right" valign="top" rowspan="1" colspan="1">242034263</td><td align="center" valign="top" rowspan="1" colspan="1">A/G</td><td align="center" valign="top" rowspan="1" colspan="1">0.03</td><td align="center" valign="top" rowspan="1" colspan="1">0.94</td><td align="center" valign="top" rowspan="1" colspan="1">1.19 (1.03–1.39)</td><td align="left" valign="top" rowspan="1" colspan="1">0.021</td><td align="center" valign="top" rowspan="1" colspan="1">1.15 (1.09–1.22)</td><td align="left" valign="top" rowspan="1" colspan="1">2.60×10<sup>−7</sup></td><td align="left" valign="top" rowspan="1" colspan="1">1.82×10<sup>−8</sup></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>EXO1</italic></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>-</italic></td><td align="left" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs6796502</td><td align="center" valign="top" rowspan="1" colspan="1">3p21.3</td><td align="right" valign="top" rowspan="1" colspan="1">46866866</td><td align="center" valign="top" rowspan="1" colspan="1">G/A</td><td align="center" valign="top" rowspan="1" colspan="1">0.09</td><td align="center" valign="top" rowspan="1" colspan="1">0.91</td><td align="center" valign="top" rowspan="1" colspan="1">0.92 (0.87–0.98)</td><td align="left" valign="top" rowspan="1" colspan="1">0.00657</td><td align="center" valign="top" rowspan="1" colspan="1">0.92 (0.89–0.95)</td><td align="left" valign="top" rowspan="1" colspan="1">8.13×10<sup>−7</sup></td><td align="left" valign="top" rowspan="1" colspan="1">1.84×10<sup>−8</sup></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>-</italic></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>-</italic></td><td align="left" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs13162653</td><td align="center" valign="top" rowspan="1" colspan="1">5p15.1</td><td align="right" valign="top" rowspan="1" colspan="1">16187528</td><td align="center" valign="top" rowspan="1" colspan="1">G/T</td><td align="center" valign="top" rowspan="1" colspan="1">0.45</td><td align="center" valign="top" rowspan="1" colspan="1">0.72</td><td align="center" valign="top" rowspan="1" colspan="1">0.92 (0.88–0.95)</td><td align="left" valign="top" rowspan="1" colspan="1">5.18×10<sup>−6</sup></td><td align="center" valign="top" rowspan="1" colspan="1">0.95 (0.93–0.97)</td><td align="left" valign="top" rowspan="1" colspan="1">1.71×10<sup>−6</sup></td><td align="left" valign="top" rowspan="1" colspan="1">1.08×10<sup>−10</sup></td><td align="left" valign="top" rowspan="1" colspan="1">-</td><td align="left" valign="top" rowspan="1" colspan="1"><italic>-</italic></td><td align="left" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs2012709</td><td align="center" valign="top" rowspan="1" colspan="1">5p13.3</td><td align="right" valign="top" rowspan="1" colspan="1">32567732</td><td align="center" valign="top" rowspan="1" colspan="1">C/T</td><td align="center" valign="top" rowspan="1" colspan="1">0.46</td><td align="center" valign="top" rowspan="1" colspan="1">0.81</td><td align="center" valign="top" rowspan="1" colspan="1">1.06 (1.02–1.09)</td><td align="left" valign="top" rowspan="1" colspan="1">0.00101</td><td align="center" valign="top" rowspan="1" colspan="1">1.05 (1.03–1.08)</td><td align="left" valign="top" rowspan="1" colspan="1">1.66×10<sup>−6</sup></td><td align="left" valign="top" rowspan="1" colspan="1">6.38×10<sup>−9</sup></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>-</italic></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>-</italic></td><td align="left" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs7707921</td><td align="center" valign="top" rowspan="1" colspan="1">5q14</td><td align="right" valign="top" rowspan="1" colspan="1">81538046</td><td align="center" valign="top" rowspan="1" colspan="1">A/T</td><td align="center" valign="top" rowspan="1" colspan="1">0.23</td><td align="center" valign="top" rowspan="1" colspan="1">0.88</td><td align="center" valign="top" rowspan="1" colspan="1">0.94 (0.9–0.98)</td><td align="left" valign="top" rowspan="1" colspan="1">0.00302</td><td align="center" valign="top" rowspan="1" colspan="1">0.93 (0.91–0.95)</td><td align="left" valign="top" rowspan="1" colspan="1">4.09×10<sup>−9</sup></td><td align="left" valign="top" rowspan="1" colspan="1">5.00×10<sup>−11</sup></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>ATG10</italic></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>-</italic></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>RPS23, ATP6AP1L</italic></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs9257408</td><td align="center" valign="top" rowspan="1" colspan="1">6p22.1</td><td align="right" valign="top" rowspan="1" colspan="1">28926220</td><td align="center" valign="top" rowspan="1" colspan="1">G/C</td><td align="center" valign="top" rowspan="1" colspan="1">0.38</td><td align="center" valign="top" rowspan="1" colspan="1">0.92</td><td align="center" valign="top" rowspan="1" colspan="1">1.05 (1–1.1)</td><td align="left" valign="top" rowspan="1" colspan="1">0.0372</td><td align="center" valign="top" rowspan="1" colspan="1">1.05 (1.03–1.08)</td><td align="left" valign="top" rowspan="1" colspan="1">4.53×10<sup>−7</sup></td><td align="left" valign="top" rowspan="1" colspan="1">4.84×10<sup>−8</sup></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>-</italic></td><td align="left" valign="top" rowspan="1" colspan="1">-</td><td align="left" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs4593472</td><td align="center" valign="top" rowspan="1" colspan="1">7q32.3</td><td align="right" valign="top" rowspan="1" colspan="1">130667121</td><td align="center" valign="top" rowspan="1" colspan="1">C/T</td><td align="center" valign="top" rowspan="1" colspan="1">0.35</td><td align="center" valign="top" rowspan="1" colspan="1">1.00</td><td align="center" valign="top" rowspan="1" colspan="1">0.92 (0.88–0.96)</td><td align="left" valign="top" rowspan="1" colspan="1">2.57×10<sup>−5</sup></td><td align="center" valign="top" rowspan="1" colspan="1">0.95 (0.94–0.97)</td><td align="left" valign="top" rowspan="1" colspan="1">3.97×10<sup>−6</sup></td><td align="left" valign="top" rowspan="1" colspan="1">1.83×10<sup>−9</sup></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>FLJ43663</italic></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>-</italic></td><td align="left" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs13365225</td><td align="center" valign="top" rowspan="1" colspan="1">8p11.23</td><td align="right" valign="top" rowspan="1" colspan="1">36858483</td><td align="center" valign="top" rowspan="1" colspan="1">A/G</td><td align="center" valign="top" rowspan="1" colspan="1">0.17</td><td align="center" valign="top" rowspan="1" colspan="1">0.94</td><td align="center" valign="top" rowspan="1" colspan="1">0.89 (0.85–0.93)</td><td align="left" valign="top" rowspan="1" colspan="1">6.32×10<sup>−7</sup></td><td align="center" valign="top" rowspan="1" colspan="1">0.95 (0.93–0.98)</td><td align="left" valign="top" rowspan="1" colspan="1">0.000159</td><td align="left" valign="top" rowspan="1" colspan="1">1.06×10<sup>−8</sup></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>-</italic></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>-</italic></td><td align="left" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs13267382</td><td align="center" valign="top" rowspan="1" colspan="1">8q23.3</td><td align="right" valign="top" rowspan="1" colspan="1">117209548</td><td align="center" valign="top" rowspan="1" colspan="1">G/A</td><td align="center" valign="top" rowspan="1" colspan="1">0.36</td><td align="center" valign="top" rowspan="1" colspan="1">0.97</td><td align="center" valign="top" rowspan="1" colspan="1">1.07 (1.03–1.12)</td><td align="left" valign="top" rowspan="1" colspan="1">0.000537</td><td align="center" valign="top" rowspan="1" colspan="1">1.05 (1.03–1.07)</td><td align="left" valign="top" rowspan="1" colspan="1">4.87×10<sup>−6</sup></td><td align="left" valign="top" rowspan="1" colspan="1">1.72×10<sup>−8</sup></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>LINC00536</italic></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>-</italic></td><td align="left" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs11627032</td><td align="center" valign="top" rowspan="1" colspan="1">14q32.12</td><td align="right" valign="top" rowspan="1" colspan="1">93104072</td><td align="center" valign="top" rowspan="1" colspan="1">T/C</td><td align="center" valign="top" rowspan="1" colspan="1">0.26</td><td align="center" valign="top" rowspan="1" colspan="1">0.73</td><td align="center" valign="top" rowspan="1" colspan="1">0.94 (0.9–0.98)</td><td align="left" valign="top" rowspan="1" colspan="1">0.00114</td><td align="center" valign="top" rowspan="1" colspan="1">0.94 (0.92–0.96)</td><td align="left" valign="top" rowspan="1" colspan="1">1.06×10<sup>−6</sup></td><td align="left" valign="top" rowspan="1" colspan="1">4.48×10<sup>−9</sup></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>RIN3</italic></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>-</italic></td><td align="left" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">chr17:29230520</td><td align="center" valign="top" rowspan="1" colspan="1">17q11.2</td><td align="right" valign="top" rowspan="1" colspan="1">29230520</td><td align="center" valign="top" rowspan="1" colspan="1">GGT/G</td><td align="center" valign="top" rowspan="1" colspan="1">0.20</td><td align="center" valign="top" rowspan="1" colspan="1">0.77</td><td align="center" valign="top" rowspan="1" colspan="1">0.94 (0.89–0.98)</td><td align="left" valign="top" rowspan="1" colspan="1">0.009</td><td align="center" valign="top" rowspan="1" colspan="1">0.93 (0.91–0.96)</td><td align="left" valign="top" rowspan="1" colspan="1">1.11×10<sup>−6</sup></td><td align="left" valign="top" rowspan="1" colspan="1">3.34×10<sup>−8</sup></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>ATAD5</italic></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>-</italic></td><td align="left" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs745570</td><td align="center" valign="top" rowspan="1" colspan="1">17q25.3</td><td align="right" valign="top" rowspan="1" colspan="1">77781725</td><td align="center" valign="top" rowspan="1" colspan="1">A/G</td><td align="center" valign="top" rowspan="1" colspan="1">0.50</td><td align="center" valign="top" rowspan="1" colspan="1">0.93</td><td align="center" valign="top" rowspan="1" colspan="1">0.94 (0.91–0.98)</td><td align="left" valign="top" rowspan="1" colspan="1">0.000754</td><td align="center" valign="top" rowspan="1" colspan="1">0.95 (0.93–0.97)</td><td align="left" valign="top" rowspan="1" colspan="1">4.52×10<sup>−7</sup></td><td align="left" valign="top" rowspan="1" colspan="1">1.40×10<sup>−9</sup></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>-</italic></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>-</italic></td><td align="left" valign="top" rowspan="1" colspan="1">-</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">rs6507583</td><td align="center" valign="top" rowspan="1" colspan="1">18q12.3</td><td align="right" valign="top" rowspan="1" colspan="1">42399590</td><td align="center" valign="top" rowspan="1" colspan="1">A/G</td><td align="center" valign="top" rowspan="1" colspan="1">0.07</td><td align="center" valign="top" rowspan="1" colspan="1">0.96</td><td align="center" valign="top" rowspan="1" colspan="1">0.91 (0.85–0.98)</td><td align="left" valign="top" rowspan="1" colspan="1">0.00803</td><td align="center" valign="top" rowspan="1" colspan="1">0.91 (0.88–0.95)</td><td align="left" valign="top" rowspan="1" colspan="1">1.21×10<sup>−6</sup></td><td align="left" valign="top" rowspan="1" colspan="1">3.20×10<sup>−8</sup></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>SETBP1</italic></td><td align="left" valign="top" rowspan="1" colspan="1"><italic>SETBP1</italic></td><td align="left" valign="top" rowspan="1" colspan="1">-</td></tr></tbody></table><table-wrap-foot><fn id="TFN1"><label>1</label><p>Chromosome</p></fn><fn id="TFN2"><label>2</label><p>Build 37 position</p></fn><fn id="TFN3"><label>3</label><p>Reference/effect allele, based on the forward strand</p></fn><fn id="TFN4"><label>4</label><p>Mean effect allele frequency over all controls</p></fn><fn id="TFN5"><label>5</label><p>Imputation r<sup>2</sup> in the iCOGS samples (calculated by the average info score from IMPUTEv2)</p></fn><fn id="TFN6"><label>6</label><p>Per allele odds ratio for the minor allele relative to the major allele</p></fn><fn id="TFN7"><label>7</label><p>P value for the 1df trend test</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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