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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Breast cancer risk variants at 6q25 display different phenotype
associations and regulate <italic>ESR1</italic>, <italic>RMND1</italic> and
<italic>CCDC170</italic></title><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M" last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Kuchenbaecker, Karoline B" sort="Kuchenbaecker, Karoline B" uniqKey="Kuchenbaecker K" first="Karoline B" last="Kuchenbaecker">Karoline B. Kuchenbaecker</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Thompson, Deborah" sort="Thompson, Deborah" uniqKey="Thompson D" first="Deborah" last="Thompson">Deborah Thompson</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="French, Juliet D" sort="French, Juliet D" uniqKey="French J" first="Juliet D" last="French">Juliet D. French</name><affiliation><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Healey, Catherine S" sort="Healey, Catherine S" uniqKey="Healey C" first="Catherine S" last="Healey">Catherine S. Healey</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Kar, Siddhartha" sort="Kar, Siddhartha" uniqKey="Kar S" first="Siddhartha" last="Kar">Siddhartha Kar</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Pooley, Karen A" sort="Pooley, Karen A" uniqKey="Pooley K" first="Karen A" last="Pooley">Karen A. Pooley</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Lopez Knowles, Elena" sort="Lopez Knowles, Elena" uniqKey="Lopez Knowles E" first="Elena" last="Lopez-Knowles">Elena Lopez-Knowles</name><affiliation><nlm:aff id="A4">Breast Cancer Research, Breakthrough Breast Cancer Research Centre, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Academic Biochemistry, Royal Marsden Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Dicks, Ed" sort="Dicks, Ed" uniqKey="Dicks E" first="Ed" last="Dicks">Ed Dicks</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Barrowdale, Daniel" sort="Barrowdale, Daniel" uniqKey="Barrowdale D" first="Daniel" last="Barrowdale">Daniel Barrowdale</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Sinnott Armstrong, Nicholas A" sort="Sinnott Armstrong, Nicholas A" uniqKey="Sinnott Armstrong N" first="Nicholas A" last="Sinnott-Armstrong">Nicholas A. Sinnott-Armstrong</name><affiliation><nlm:aff id="A6">Department of Genetics, Stanford University School of Medicine, Stanford, California, USA</nlm:aff></affiliation></author><author><name sortKey="Sallari, Richard C" sort="Sallari, Richard C" uniqKey="Sallari R" first="Richard C" last="Sallari">Richard C. Sallari</name><affiliation><nlm:aff id="A7">Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Hillman, Kristine M" sort="Hillman, Kristine M" uniqKey="Hillman K" first="Kristine M" last="Hillman">Kristine M. Hillman</name><affiliation><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Kaufmann, Susanne" sort="Kaufmann, Susanne" uniqKey="Kaufmann S" first="Susanne" last="Kaufmann">Susanne Kaufmann</name><affiliation><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Sivakumaran, Haran" sort="Sivakumaran, Haran" uniqKey="Sivakumaran H" first="Haran" last="Sivakumaran">Haran Sivakumaran</name><affiliation><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Marjaneh, Mahdi Moradi" sort="Marjaneh, Mahdi Moradi" uniqKey="Marjaneh M" first="Mahdi Moradi" last="Marjaneh">Mahdi Moradi Marjaneh</name><affiliation><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Lee, Jason S" sort="Lee, Jason S" uniqKey="Lee J" first="Jason S" last="Lee">Jason S. Lee</name><affiliation><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Hills, Margaret" sort="Hills, Margaret" uniqKey="Hills M" first="Margaret" last="Hills">Margaret Hills</name><affiliation><nlm:aff id="A5">Academic Biochemistry, Royal Marsden Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Jarosz, Monika" sort="Jarosz, Monika" uniqKey="Jarosz M" first="Monika" last="Jarosz">Monika Jarosz</name><affiliation><nlm:aff id="A4">Breast Cancer Research, Breakthrough Breast Cancer Research Centre, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Academic Biochemistry, Royal Marsden Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Drury, Suzie" sort="Drury, Suzie" uniqKey="Drury S" first="Suzie" last="Drury">Suzie Drury</name><affiliation><nlm:aff id="A4">Breast Cancer Research, Breakthrough Breast Cancer Research Centre, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Academic Biochemistry, Royal Marsden Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Canisius, Sander" sort="Canisius, Sander" uniqKey="Canisius S" first="Sander" last="Canisius">Sander Canisius</name><affiliation><nlm:aff id="A8">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K" last="Bolla">Manjeet K. Bolla</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="A9">Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="A10">Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation><nlm:aff id="A8">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K" last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="A8">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name><affiliation><nlm:aff id="A11">Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK</nlm:aff></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation><nlm:aff id="A11">Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Institute of Population Health, University of Manchester, Manchester, UK</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W" last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="A13">Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg Metropolitan Region, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A" last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="A13">Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg Metropolitan Region, Erlangen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><affiliation><nlm:aff id="A15">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="A15">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J" last="Sawyer">Elinor J. Sawyer</name><affiliation><nlm:aff id="A16">Research Oncology, Division of Cancer Studies, King’s College London, Guy’s Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation><nlm:aff id="A17">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Oxford Biomedical Research Centre, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="A19">Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Molecular Epidemiology Group, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><affiliation><nlm:aff id="A21">National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation><nlm:aff id="A23">Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A24">University Paris–Sud, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation><nlm:aff id="A23">Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A24">University Paris–Sud, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E" last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="A25">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A26">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="A28">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name><affiliation><nlm:aff id="A29">Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Perez, Jose I A" sort="Perez, Jose I A" uniqKey="Perez J" first="Jose I A" last="Perez">Jose I A. Perez</name><affiliation><nlm:aff id="A30">Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain</nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="A31">Department of Epidemiology, University of California–Irvine, Irvine, California, USA</nlm:aff></affiliation></author><author><name sortKey="Eunjung, Lee" sort="Eunjung, Lee" uniqKey="Eunjung L" first="Lee" last="Eunjung">Lee Eunjung</name><affiliation><nlm:aff id="A32">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="A33">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="A33">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A34">German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="A35">Department of Gynaecology and Obstetrics, Technical University of Munich, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K" last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="A36">Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Centre of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Center for Integrated Oncology, University Hospital, Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="A34">German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A40">University of Tübingen, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="A41">Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="A42">Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation><nlm:aff id="A43">Department of Oncology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Ito, Hidemi" sort="Ito, Hidemi" uniqKey="Ito H" first="Hidemi" last="Ito">Hidemi Ito</name><affiliation><nlm:aff id="A44">Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Aichi, Japan</nlm:aff></affiliation></author><author><name sortKey="Matsuo, Keitaro" sort="Matsuo, Keitaro" uniqKey="Matsuo K" first="Keitaro" last="Matsuo">Keitaro Matsuo</name><affiliation><nlm:aff id="A45">Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan</nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natasha" sort="Bogdanova, Natasha" uniqKey="Bogdanova N" first="Natasha" last="Bogdanova">Natasha Bogdanova</name><affiliation><nlm:aff id="A46">Radiation Oncology Research Unit, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="A47">Gynaecology Research Unit, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff id="A48">Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation><nlm:aff id="A49">Department of Oncology-Pathology, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff id="A50">Cancer Center, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A51">Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff id="A50">Cancer Center, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A51">Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Tseng, Chiu Chen" sort="Tseng, Chiu Chen" uniqKey="Tseng C" first="Chiu-Chen" last="Tseng">Chiu-Chen Tseng</name><affiliation><nlm:aff id="A32">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Wu, Anna H" sort="Wu, Anna H" uniqKey="Wu A" first="Anna H" last="Wu">Anna H. Wu</name><affiliation><nlm:aff id="A32">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="A53">Vesalius Research Center, Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A54">Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Wildiers, Hans" sort="Wildiers, Hans" uniqKey="Wildiers H" first="Hans" last="Wildiers">Hans Wildiers</name><affiliation><nlm:aff id="A55">Multidisciplinary Breast Center, Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="A56">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A57">University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="A56">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="A58">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="A59">Unit of Molecular Basis of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E" last="Olson">Janet E. Olson</name><affiliation><nlm:aff id="A60">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="A9">Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L" last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="A9">Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A" last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="A32">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E" last="Henderson">Brian E. Henderson</name><affiliation><nlm:aff id="A32">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Goldberg, Mark S" sort="Goldberg, Mark S" uniqKey="Goldberg M" first="Mark S" last="Goldberg">Mark S. Goldberg</name><affiliation><nlm:aff id="A62">Department of Medicine, McGill University, Montreal, Quebec, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A63">Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Teo, Soo H" sort="Teo, Soo H" uniqKey="Teo S" first="Soo H" last="Teo">Soo H. Teo</name><affiliation><nlm:aff id="A64">Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Yip, Cheng Har" sort="Yip, Cheng Har" uniqKey="Yip C" first="Cheng Har" last="Yip">Cheng Har Yip</name><affiliation><nlm:aff id="A65">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Nord, Silje" sort="Nord, Silje" uniqKey="Nord S" first="Silje" last="Nord">Silje Nord</name><affiliation><nlm:aff id="A66">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Borresen Dale, Anne Lise" sort="Borresen Dale, Anne Lise" uniqKey="Borresen Dale A" first="Anne-Lise" last="Borresen-Dale">Anne-Lise Borresen-Dale</name><affiliation><nlm:aff id="A66">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A67">Institute of Clinical Medicine, University of Oslo, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation><nlm:aff id="A66">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A67">Institute of Clinical Medicine, University of Oslo, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A68">Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Long, Jirong" sort="Long, Jirong" uniqKey="Long J" first="Jirong" last="Long">Jirong Long</name><affiliation><nlm:aff id="A69">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA</nlm:aff></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:aff id="A69">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA</nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation><nlm:aff id="A70">Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A71">Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="A70">Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A71">Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L" last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="A72">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A73">Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A" last="Knight">Julia A. Knight</name><affiliation><nlm:aff id="A74">Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A75">Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:aff id="A76">Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A77">Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name><affiliation><nlm:aff id="A78">Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name><affiliation><nlm:aff id="A79">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Sherman, Mark E" sort="Sherman, Mark E" uniqKey="Sherman M" first="Mark E" last="Sherman">Mark E. Sherman</name><affiliation><nlm:aff id="A79">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="A80">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name><affiliation><nlm:aff id="A80">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation><nlm:aff id="A78">Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Den Ouweland, Ans M W" sort="Van Den Ouweland, Ans M W" uniqKey="Van Den Ouweland A" first="Ans M W" last="Van Den Ouweland">Ans M W. Van Den Ouweland</name><affiliation><nlm:aff id="A81">Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name><affiliation><nlm:aff id="A80">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Gao, Yu Tang" sort="Gao, Yu Tang" uniqKey="Gao Y" first="Yu-Tang" last="Gao">Yu-Tang Gao</name><affiliation><nlm:aff id="A82">Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China</nlm:aff></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation><nlm:aff id="A69">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="A83">Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S" last="Cross">Simon S. Cross</name><affiliation><nlm:aff id="A84">Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Blot, William" sort="Blot, William" uniqKey="Blot W" first="William" last="Blot">William Blot</name><affiliation><nlm:aff id="A69">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A85">International Epidemiology Institute, Rockville, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Cai, Qiuyin" sort="Cai, Qiuyin" uniqKey="Cai Q" first="Qiuyin" last="Cai">Qiuyin Cai</name><affiliation><nlm:aff id="A69">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA</nlm:aff></affiliation></author><author><name sortKey="Ghoussaini, Maya" sort="Ghoussaini, Maya" uniqKey="Ghoussaini M" first="Maya" last="Ghoussaini">Maya Ghoussaini</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Perkins, Barbara J" sort="Perkins, Barbara J" uniqKey="Perkins B" first="Barbara J" last="Perkins">Barbara J. Perkins</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Choi, Ji Yeob" sort="Choi, Ji Yeob" uniqKey="Choi J" first="Ji-Yeob" last="Choi">Ji-Yeob Choi</name><affiliation><nlm:aff id="A86">Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A87">Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Kang, Daehee" sort="Kang, Daehee" uniqKey="Kang D" first="Daehee" last="Kang">Daehee Kang</name><affiliation><nlm:aff id="A86">Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A87">Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A88">Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Lee, Soo Chin" sort="Lee, Soo Chin" uniqKey="Lee S" first="Soo Chin" last="Lee">Soo Chin Lee</name><affiliation><nlm:aff id="A89">Department of Haematology-Oncology, National University Health System, Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="A90">Cancer Science Institute of Singapore, National University of Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Hartman, Mikael" sort="Hartman, Mikael" uniqKey="Hartman M" first="Mikael" last="Hartman">Mikael Hartman</name><affiliation><nlm:aff id="A91">Saw Swee Hock School of Public Health, National University of Singapore, Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="A92">Department of Surgery, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Kabisch, Maria" sort="Kabisch, Maria" uniqKey="Kabisch M" first="Maria" last="Kabisch">Maria Kabisch</name><affiliation><nlm:aff id="A41">Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name><affiliation><nlm:aff id="A41">Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A93">Institute of Human Genetics, Pontificia Universidad Javerianar, Bogota, Colombia</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="A94">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="A94">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation><nlm:aff id="A95">International Agency for Research on Cancer, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Sangrajrang, Suleeporn" sort="Sangrajrang, Suleeporn" uniqKey="Sangrajrang S" first="Suleeporn" last="Sangrajrang">Suleeporn Sangrajrang</name><affiliation><nlm:aff id="A96">National Cancer Institute, Bangkok, Thailand</nlm:aff></affiliation></author><author><name sortKey="Ambrosone, Christine B" sort="Ambrosone, Christine B" uniqKey="Ambrosone C" first="Christine B" last="Ambrosone">Christine B. Ambrosone</name><affiliation><nlm:aff id="A97">Roswell Park Cancer Institute, Buffalo, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E" last="Toland">Amanda E. Toland</name><affiliation><nlm:aff id="A98">Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA</nlm:aff></affiliation></author><author><name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name><affiliation><nlm:aff id="A99">School of Public Health, China Medical University, Taichung, Taiwan</nlm:aff></affiliation><affiliation><nlm:aff id="A100">Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Wu, Pei Ei" sort="Wu, Pei Ei" uniqKey="Wu P" first="Pei-Ei" last="Wu">Pei-Ei Wu</name><affiliation><nlm:aff id="A100">Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><affiliation><nlm:aff id="A101">Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation><nlm:aff id="A102">Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A103">Division of Breast Cancer Research, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name><affiliation><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Lee, Andrew" sort="Lee, Andrew" uniqKey="Lee A" first="Andrew" last="Lee">Andrew Lee</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Kapuscinski, Miroslav" sort="Kapuscinski, Miroslav" uniqKey="Kapuscinski M" first="Miroslav" last="Kapuscinski">Miroslav Kapuscinski</name><affiliation><nlm:aff id="A104">Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M" last="John">Esther M. John</name><affiliation><nlm:aff id="A105">Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California, USA</nlm:aff></affiliation></author><author><name sortKey="Terry, Mary Beth" sort="Terry, Mary Beth" uniqKey="Terry M" first="Mary Beth" last="Terry">Mary Beth Terry</name><affiliation><nlm:aff id="A106">Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B" last="Daly">Mary B. Daly</name><affiliation><nlm:aff id="A107">Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E" last="Goldgar">David E. Goldgar</name><affiliation><nlm:aff id="A108">Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA</nlm:aff></affiliation></author><author><name sortKey="Buys, Saundra S" sort="Buys, Saundra S" uniqKey="Buys S" first="Saundra S" last="Buys">Saundra S. Buys</name><affiliation><nlm:aff id="A109">Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA</nlm:aff></affiliation></author><author><name sortKey="Janavicius, Ramunas" sort="Janavicius, Ramunas" uniqKey="Janavicius R" first="Ramunas" last="Janavicius">Ramunas Janavicius</name><affiliation><nlm:aff id="A110">State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania</nlm:aff></affiliation></author><author><name sortKey="Tihomirova, Laima" sort="Tihomirova, Laima" uniqKey="Tihomirova L" first="Laima" last="Tihomirova">Laima Tihomirova</name><affiliation><nlm:aff id="A111">Latvian Biomedical Research and Study Centre, Riga, Latvia</nlm:aff></affiliation></author><author><name sortKey="Tung, Nadine" sort="Tung, Nadine" uniqKey="Tung N" first="Nadine" last="Tung">Nadine Tung</name><affiliation><nlm:aff id="A112">Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Dorfling, Cecilia M" sort="Dorfling, Cecilia M" uniqKey="Dorfling C" first="Cecilia M" last="Dorfling">Cecilia M. Dorfling</name><affiliation><nlm:aff id="A113">Department of Genetics, University of Pretoria, Pretoria, South Africa</nlm:aff></affiliation></author><author><name sortKey="Van Rensburg, Elizabeth J" sort="Van Rensburg, Elizabeth J" uniqKey="Van Rensburg E" first="Elizabeth J" last="Van Rensburg">Elizabeth J. Van Rensburg</name><affiliation><nlm:aff id="A113">Department of Genetics, University of Pretoria, Pretoria, South Africa</nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L" last="Neuhausen">Susan L. Neuhausen</name><affiliation><nlm:aff id="A114">Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, USA</nlm:aff></affiliation></author><author><name sortKey="Ejlertsen, Bent" sort="Ejlertsen, Bent" uniqKey="Ejlertsen B" first="Bent" last="Ejlertsen">Bent Ejlertsen</name><affiliation><nlm:aff id="A115">Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Hansen, Thomas V O" sort="Hansen, Thomas V O" uniqKey="Hansen T" first="Thomas V O" last="Hansen">Thomas V O. Hansen</name><affiliation><nlm:aff id="A116">Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name><affiliation><nlm:aff id="A117">Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A118">Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="A117">Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A118">Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A119">Human Genotyping (CEGEN) Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Rando, Rachel" sort="Rando, Rachel" uniqKey="Rando R" first="Rachel" last="Rando">Rachel Rando</name><affiliation><nlm:aff id="A120">City of Hope Clinical Cancer Genomics Community Research Network, Duarte, California, USA</nlm:aff></affiliation></author><author><name sortKey="Weitzel, Jeffrey N" sort="Weitzel, Jeffrey N" uniqKey="Weitzel J" first="Jeffrey N" last="Weitzel">Jeffrey N. Weitzel</name><affiliation><nlm:aff id="A121">Clinical Cancer Genetics, City of Hope, Duarte, California, USA</nlm:aff></affiliation></author><author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name><affiliation><nlm:aff id="A122">Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Peissel, Bernard" sort="Peissel, Bernard" uniqKey="Peissel B" first="Bernard" last="Peissel">Bernard Peissel</name><affiliation><nlm:aff id="A123">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale Tumori, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="A123">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale Tumori, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Papi, Laura" sort="Papi, Laura" uniqKey="Papi L" first="Laura" last="Papi">Laura Papi</name><affiliation><nlm:aff id="A124">Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Ottini, Laura" sort="Ottini, Laura" uniqKey="Ottini L" first="Laura" last="Ottini">Laura Ottini</name><affiliation><nlm:aff id="A125">Department of Molecular Medicine, University La Sapienza, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Konstantopoulou, Irene" sort="Konstantopoulou, Irene" uniqKey="Konstantopoulou I" first="Irene" last="Konstantopoulou">Irene Konstantopoulou</name><affiliation><nlm:aff id="A126">Molecular Diagnostics Laboratory, INRASTES (Institute of Nuclear and Radiological Sciences and Technology), National Centre for Scientific Research ‘Demokritos’, Aghia Paraskevi Attikis, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Apostolou, Paraskevi" sort="Apostolou, Paraskevi" uniqKey="Apostolou P" first="Paraskevi" last="Apostolou">Paraskevi Apostolou</name><affiliation><nlm:aff id="A126">Molecular Diagnostics Laboratory, INRASTES (Institute of Nuclear and Radiological Sciences and Technology), National Centre for Scientific Research ‘Demokritos’, Aghia Paraskevi Attikis, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Garber, Judy" sort="Garber, Judy" uniqKey="Garber J" first="Judy" last="Garber">Judy Garber</name><affiliation><nlm:aff id="A127">Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Rashid, Muhammad Usman" sort="Rashid, Muhammad Usman" uniqKey="Rashid M" first="Muhammad Usman" last="Rashid">Muhammad Usman Rashid</name><affiliation><nlm:aff id="A41">Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A128">Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan</nlm:aff></affiliation></author><author><name sortKey="Frost, Debra" sort="Frost, Debra" uniqKey="Frost D" first="Debra" last="Frost">Debra Frost</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Izatt, Louise" sort="Izatt, Louise" uniqKey="Izatt L" first="Louise" last="Izatt">Louise Izatt</name><affiliation><nlm:aff id="A129">Clinical Genetics, Guy’s and St. Thomas’ National Health Service (NHS) Foundation Trust, London, UK</nlm:aff></affiliation></author><author><name sortKey="Ellis, Steve" sort="Ellis, Steve" uniqKey="Ellis S" first="Steve" last="Ellis">Steve Ellis</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K" last="Godwin">Andrew K. Godwin</name><affiliation><nlm:aff id="A130">Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA</nlm:aff></affiliation></author><author><name sortKey="Arnold, Norbert" sort="Arnold, Norbert" uniqKey="Arnold N" first="Norbert" last="Arnold">Norbert Arnold</name><affiliation><nlm:aff id="A131">Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian Albrechts University Kiel, Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Niederacher, Dieter" sort="Niederacher, Dieter" uniqKey="Niederacher D" first="Dieter" last="Niederacher">Dieter Niederacher</name><affiliation><nlm:aff id="A132">University Düsseldorf, Dusseldorf, Germany</nlm:aff></affiliation></author><author><name sortKey="Rhiem, Kerstin" sort="Rhiem, Kerstin" uniqKey="Rhiem K" first="Kerstin" last="Rhiem">Kerstin Rhiem</name><affiliation><nlm:aff id="A133">Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology, Center for Molecular Medicine Cologne, University Hospital of Cologne, Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Bogdanova Markov, Nadja" sort="Bogdanova Markov, Nadja" uniqKey="Bogdanova Markov N" first="Nadja" last="Bogdanova-Markov">Nadja Bogdanova-Markov</name><affiliation><nlm:aff id="A134">Institute of Human Genetics, Münster, Germany</nlm:aff></affiliation></author><author><name sortKey="Sagne, Charlotte" sort="Sagne, Charlotte" uniqKey="Sagne C" first="Charlotte" last="Sagne">Charlotte Sagne</name><affiliation><nlm:aff id="A135">INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><affiliation><nlm:aff id="A136">Institut Curie, Department of Tumour Biology, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A137">Université Paris Descartes, Sorbonne Paris Cité, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Damiola, Francesca" sort="Damiola, Francesca" uniqKey="Damiola F" first="Francesca" last="Damiola">Francesca Damiola</name><affiliation><nlm:aff id="A135">INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M" last="Sinilnikova">Olga M. Sinilnikova</name><affiliation><nlm:aff id="A135">INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="A138">Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon–Centre Léon Bérard, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name><affiliation><nlm:aff id="A135">INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Isaacs, Claudine" sort="Isaacs, Claudine" uniqKey="Isaacs C" first="Claudine" last="Isaacs">Claudine Isaacs</name><affiliation><nlm:aff id="A139">Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA</nlm:aff></affiliation></author><author><name sortKey="Claes, Kathleen B M" sort="Claes, Kathleen B M" uniqKey="Claes K" first="Kathleen B M" last="Claes">Kathleen B M. Claes</name><affiliation><nlm:aff id="A140">Center for Medical Genetics, Ghent University, Ghent, Belgium</nlm:aff></affiliation></author><author><name sortKey="De Leeneer, Kim" sort="De Leeneer, Kim" uniqKey="De Leeneer K" first="Kim" last="De Leeneer">Kim De Leeneer</name><affiliation><nlm:aff id="A140">Center for Medical Genetics, Ghent University, Ghent, Belgium</nlm:aff></affiliation></author><author><name sortKey="De La Hoya, Miguel" sort="De La Hoya, Miguel" uniqKey="De La Hoya M" first="Miguel" last="De La Hoya">Miguel De La Hoya</name><affiliation><nlm:aff id="A141">Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Caldes, Trinidad" sort="Caldes, Trinidad" uniqKey="Caldes T" first="Trinidad" last="Caldes">Trinidad Caldes</name><affiliation><nlm:aff id="A141">Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="A142">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Khan, Sofia" sort="Khan, Sofia" uniqKey="Khan S" first="Sofia" last="Khan">Sofia Khan</name><affiliation><nlm:aff id="A142">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Mensenkamp, Arjen R" sort="Mensenkamp, Arjen R" uniqKey="Mensenkamp A" first="Arjen R" last="Mensenkamp">Arjen R. Mensenkamp</name><affiliation><nlm:aff id="A143">Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J" last="Hooning">Maartje J. Hooning</name><affiliation><nlm:aff id="A144">Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Rookus, Matti A" sort="Rookus, Matti A" uniqKey="Rookus M" first="Matti A" last="Rookus">Matti A. Rookus</name><affiliation><nlm:aff id="A145">Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kwong, Ava" sort="Kwong, Ava" uniqKey="Kwong A" first="Ava" last="Kwong">Ava Kwong</name><affiliation><nlm:aff id="A146">Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong</nlm:aff></affiliation><affiliation><nlm:aff id="A147">Department of Surgery, University of Hong Kong, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Olah, Edith" sort="Olah, Edith" uniqKey="Olah E" first="Edith" last="Olah">Edith Olah</name><affiliation><nlm:aff id="A148">Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary</nlm:aff></affiliation></author><author><name sortKey="Diez, Orland" sort="Diez, Orland" uniqKey="Diez O" first="Orland" last="Diez">Orland Diez</name><affiliation><nlm:aff id="A149">Oncogenetics Laboratory, Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron University Hospital, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Brunet, Joan" sort="Brunet, Joan" uniqKey="Brunet J" first="Joan" last="Brunet">Joan Brunet</name><affiliation><nlm:aff id="A150">Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d’Investigació Biomèdica de Girona), Catalan Institute of Oncology, Girona, Spain</nlm:aff></affiliation></author><author><name sortKey="Pujana, Miquel Angel" sort="Pujana, Miquel Angel" uniqKey="Pujana M" first="Miquel Angel" last="Pujana">Miquel Angel Pujana</name><affiliation><nlm:aff id="A151">Breast Cancer and Systems Biology Unit, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Gronwald, Jacek" sort="Gronwald, Jacek" uniqKey="Gronwald J" first="Jacek" last="Gronwald">Jacek Gronwald</name><affiliation><nlm:aff id="A94">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Huzarski, Tomasz" sort="Huzarski, Tomasz" uniqKey="Huzarski T" first="Tomasz" last="Huzarski">Tomasz Huzarski</name><affiliation><nlm:aff id="A94">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Barkardottir, Rosa B" sort="Barkardottir, Rosa B" uniqKey="Barkardottir R" first="Rosa B" last="Barkardottir">Rosa B. Barkardottir</name><affiliation><nlm:aff id="A152">Department of Pathology, Landspitali University Hospital and Biomedical Centre (BMC), Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Laframboise, Rachel" sort="Laframboise, Rachel" uniqKey="Laframboise R" first="Rachel" last="Laframboise">Rachel Laframboise</name><affiliation><nlm:aff id="A153">Medical Genetic Division, Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name><affiliation><nlm:aff id="A154">Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name><affiliation><nlm:aff id="A155">Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV), IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Padua, Italy</nlm:aff></affiliation></author><author><name sortKey="Agata, Simona" sort="Agata, Simona" uniqKey="Agata S" first="Simona" last="Agata">Simona Agata</name><affiliation><nlm:aff id="A155">Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV), IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Padua, Italy</nlm:aff></affiliation></author><author><name sortKey="Teixeira, Manuel R" sort="Teixeira, Manuel R" uniqKey="Teixeira M" first="Manuel R" last="Teixeira">Manuel R. Teixeira</name><affiliation><nlm:aff id="A156">Department of Genetics, Portuguese Oncology Institute, Porto, Portugal</nlm:aff></affiliation><affiliation><nlm:aff id="A157">Biomedical Sciences Institute (ICBAS), Porto University, Porto, Portugal</nlm:aff></affiliation></author><author><name sortKey="Park, Sue Kyung" sort="Park, Sue Kyung" uniqKey="Park S" first="Sue Kyung" last="Park">Sue Kyung Park</name><affiliation><nlm:aff id="A86">Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A87">Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A88">Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Lindor, Noralane" sort="Lindor, Noralane" uniqKey="Lindor N" first="Noralane" last="Lindor">Noralane Lindor</name><affiliation><nlm:aff id="A60">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J" last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="A60">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A158">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Tischkowitz, Marc" sort="Tischkowitz, Marc" uniqKey="Tischkowitz M" first="Marc" last="Tischkowitz">Marc Tischkowitz</name><affiliation><nlm:aff id="A159">Program in Cancer Genetics, McGill University, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Foretova, Lenka" sort="Foretova, Lenka" uniqKey="Foretova L" first="Lenka" last="Foretova">Lenka Foretova</name><affiliation><nlm:aff id="A160">Masaryk Memorial Cancer Institute and Medical Faculty, Masaryk University, Brno, Czech Republic</nlm:aff></affiliation></author><author><name sortKey="Vijai, Joseph" sort="Vijai, Joseph" uniqKey="Vijai J" first="Joseph" last="Vijai">Joseph Vijai</name><affiliation><nlm:aff id="A161">Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation><nlm:aff id="A161">Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Singer, Christian F" sort="Singer, Christian F" uniqKey="Singer C" first="Christian F" last="Singer">Christian F. Singer</name><affiliation><nlm:aff id="A162">Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Rappaport, Christine" sort="Rappaport, Christine" uniqKey="Rappaport C" first="Christine" last="Rappaport">Christine Rappaport</name><affiliation><nlm:aff id="A162">Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Phelan, Catherine M" sort="Phelan, Catherine M" uniqKey="Phelan C" first="Catherine M" last="Phelan">Catherine M. Phelan</name><affiliation><nlm:aff id="A163">Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA</nlm:aff></affiliation></author><author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H" last="Greene">Mark H. Greene</name><affiliation><nlm:aff id="A164">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Rockville, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L" last="Mai">Phuong L. Mai</name><affiliation><nlm:aff id="A164">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Rockville, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name><affiliation><nlm:aff id="A165">Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Haifa, Israel</nlm:aff></affiliation><affiliation><nlm:aff id="A166">Clalit National Israeli Cancer Control Center, Haifa, Israel</nlm:aff></affiliation></author><author><name sortKey="Imyanitov, Evgeny N" sort="Imyanitov, Evgeny N" uniqKey="Imyanitov E" first="Evgeny N" last="Imyanitov">Evgeny N. Imyanitov</name><affiliation><nlm:aff id="A167">N.N. Petrov Institute of Oncology, St. Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Hulick, Peter J" sort="Hulick, Peter J" uniqKey="Hulick P" first="Peter J" last="Hulick">Peter J. Hulick</name><affiliation><nlm:aff id="A168">Center for Medical Genetics, NorthShore University Health System, Evanston, Illinois, USA</nlm:aff></affiliation></author><author><name sortKey="Phillips, Kelly Anne" sort="Phillips, Kelly Anne" uniqKey="Phillips K" first="Kelly-Anne" last="Phillips">Kelly-Anne Phillips</name><affiliation><nlm:aff id="A169">Division of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Piedmonte, Marion" sort="Piedmonte, Marion" uniqKey="Piedmonte M" first="Marion" last="Piedmonte">Marion Piedmonte</name><affiliation><nlm:aff id="A170">NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation><nlm:aff id="A171">Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A172">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="A72">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Anders" sort="Bojesen, Anders" uniqKey="Bojesen A" first="Anders" last="Bojesen">Anders Bojesen</name><affiliation><nlm:aff id="A173">Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark</nlm:aff></affiliation></author><author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name><affiliation><nlm:aff id="A174">Department of Clinical Genetics, Odense University Hospital, Odense, Denmark</nlm:aff></affiliation></author><author><name sortKey="Caligo, Maria A" sort="Caligo, Maria A" uniqKey="Caligo M" first="Maria A" last="Caligo">Maria A. Caligo</name><affiliation><nlm:aff id="A175">Section of Genetic Oncology, Department of Laboratory Medicine, University of Pisa and University Hospital of Pisa, Pisa, Italy</nlm:aff></affiliation></author><author><name sortKey="Yoon, Sook Yee" sort="Yoon, Sook Yee" uniqKey="Yoon S" first="Sook-Yee" last="Yoon">Sook-Yee Yoon</name><affiliation><nlm:aff id="A64">Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia</nlm:aff></affiliation><affiliation><nlm:aff id="A176">University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name><affiliation><nlm:aff id="A177">Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel</nlm:aff></affiliation></author><author><name sortKey="Laitman, Yael" sort="Laitman, Yael" uniqKey="Laitman Y" first="Yael" last="Laitman">Yael Laitman</name><affiliation><nlm:aff id="A177">Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel</nlm:aff></affiliation></author><author><name sortKey="Borg, Ake" sort="Borg, Ake" uniqKey="Borg A" first="Ake" last="Borg">Ake Borg</name><affiliation><nlm:aff id="A178">Department of Oncology, Lund University, Lund, Sweden</nlm:aff></affiliation></author><author><name sortKey="Von Wachenfeldt, Anna" sort="Von Wachenfeldt, Anna" uniqKey="Von Wachenfeldt A" first="Anna" last="Von Wachenfeldt">Anna Von Wachenfeldt</name><affiliation><nlm:aff id="A49">Department of Oncology-Pathology, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Ehrencrona, Hans" sort="Ehrencrona, Hans" uniqKey="Ehrencrona H" first="Hans" last="Ehrencrona">Hans Ehrencrona</name><affiliation><nlm:aff id="A179">Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A180">Department of Clinical Genetics, Lund University Hospital, Lund, Sweden</nlm:aff></affiliation></author><author><name sortKey="Rantala, Johanna" sort="Rantala, Johanna" uniqKey="Rantala J" first="Johanna" last="Rantala">Johanna Rantala</name><affiliation><nlm:aff id="A181">Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Olopade, Olufunmilayo I" sort="Olopade, Olufunmilayo I" uniqKey="Olopade O" first="Olufunmilayo I" last="Olopade">Olufunmilayo I. Olopade</name><affiliation><nlm:aff id="A182">Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, Illinois, USA</nlm:aff></affiliation></author><author><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A" last="Ganz">Patricia A. Ganz</name><affiliation><nlm:aff id="A183">Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center, University of California Los Angeles School of Medicine and School of Public Health, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Nussbaum, Robert L" sort="Nussbaum, Robert L" uniqKey="Nussbaum R" first="Robert L" last="Nussbaum">Robert L. Nussbaum</name><affiliation><nlm:aff id="A184">Department of Medicine and Genetics, University of California, San Francisco, San Francisco, California, USA</nlm:aff></affiliation></author><author><name sortKey="Gayther, Simon A" sort="Gayther, Simon A" uniqKey="Gayther S" first="Simon A" last="Gayther">Simon A. Gayther</name><affiliation><nlm:aff id="A32">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L" last="Nathanson">Katherine L. Nathanson</name><affiliation><nlm:aff id="A185">Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M" last="Domchek">Susan M. Domchek</name><affiliation><nlm:aff id="A185">Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Arun, Banu K" sort="Arun, Banu K" uniqKey="Arun B" first="Banu K" last="Arun">Banu K. Arun</name><affiliation><nlm:aff id="A186">University of Texas MD Anderson Cancer Center, Houston, Texas, USA</nlm:aff></affiliation></author><author><name sortKey="Mitchell, Gillian" sort="Mitchell, Gillian" uniqKey="Mitchell G" first="Gillian" last="Mitchell">Gillian Mitchell</name><affiliation><nlm:aff id="A187">Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A188">Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Karlan, Beth Y" sort="Karlan, Beth Y" uniqKey="Karlan B" first="Beth Y" last="Karlan">Beth Y. Karlan</name><affiliation><nlm:aff id="A189">Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Lester, Jenny" sort="Lester, Jenny" uniqKey="Lester J" first="Jenny" last="Lester">Jenny Lester</name><affiliation><nlm:aff id="A189">Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Maskarinec, Gertraud" sort="Maskarinec, Gertraud" uniqKey="Maskarinec G" first="Gertraud" last="Maskarinec">Gertraud Maskarinec</name><affiliation><nlm:aff id="A190">University of Hawaii Cancer Center, Honolulu, Hawaii, USA</nlm:aff></affiliation></author><author><name sortKey="Woolcott, Christy" sort="Woolcott, Christy" uniqKey="Woolcott C" first="Christy" last="Woolcott">Christy Woolcott</name><affiliation><nlm:aff id="A191">Department of Obstetrics, Gynaecology and Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada</nlm:aff></affiliation></author><author><name sortKey="Scott, Christopher" sort="Scott, Christopher" uniqKey="Scott C" first="Christopher" last="Scott">Christopher Scott</name><affiliation><nlm:aff id="A60">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Stone, Jennifer" sort="Stone, Jennifer" uniqKey="Stone J" first="Jennifer" last="Stone">Jennifer Stone</name><affiliation><nlm:aff id="A192">Centre for Genetic Origins of Health and Disease, University of Western Australia, Perth, Western Australia, Australia</nlm:aff></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation><nlm:aff id="A9">Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Tamimi, Rulla" sort="Tamimi, Rulla" uniqKey="Tamimi R" first="Rulla" last="Tamimi">Rulla Tamimi</name><affiliation><nlm:aff id="A193">Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A194">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A195">Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Luben, Robert" sort="Luben, Robert" uniqKey="Luben R" first="Robert" last="Luben">Robert Luben</name><affiliation><nlm:aff id="A196">Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation><nlm:aff id="A196">Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Helland, Slaug" sort="Helland, Slaug" uniqKey="Helland " first=" Slaug" last="Helland"> Slaug Helland</name><affiliation><nlm:aff id="A66">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Haakensen, Vilde" sort="Haakensen, Vilde" uniqKey="Haakensen V" first="Vilde" last="Haakensen">Vilde Haakensen</name><affiliation><nlm:aff id="A66">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Dowsett, Mitch" sort="Dowsett, Mitch" uniqKey="Dowsett M" first="Mitch" last="Dowsett">Mitch Dowsett</name><affiliation><nlm:aff id="A4">Breast Cancer Research, Breakthrough Breast Cancer Research Centre, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Academic Biochemistry, Royal Marsden Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D P" last="Pharoah">Paul D P. Pharoah</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="A154">Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="A80">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation><nlm:aff id="A101">Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A102">Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name><affiliation><nlm:aff id="A60">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C" last="Antoniou">Antonis C. Antoniou</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F" last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Edwards, Stacey L" sort="Edwards, Stacey L" uniqKey="Edwards S" first="Stacey L" last="Edwards">Stacey L. Edwards</name><affiliation><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26928228</idno><idno type="pmc">4938803</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938803</idno><idno type="RBID">PMC:4938803</idno><idno type="doi">10.1038/ng.3521</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002152</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002152</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Breast cancer risk variants at 6q25 display different phenotype
associations and regulate <italic>ESR1</italic>, <italic>RMND1</italic> and
<italic>CCDC170</italic></title><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M" last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Kuchenbaecker, Karoline B" sort="Kuchenbaecker, Karoline B" uniqKey="Kuchenbaecker K" first="Karoline B" last="Kuchenbaecker">Karoline B. Kuchenbaecker</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Thompson, Deborah" sort="Thompson, Deborah" uniqKey="Thompson D" first="Deborah" last="Thompson">Deborah Thompson</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="French, Juliet D" sort="French, Juliet D" uniqKey="French J" first="Juliet D" last="French">Juliet D. French</name><affiliation><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Healey, Catherine S" sort="Healey, Catherine S" uniqKey="Healey C" first="Catherine S" last="Healey">Catherine S. Healey</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Kar, Siddhartha" sort="Kar, Siddhartha" uniqKey="Kar S" first="Siddhartha" last="Kar">Siddhartha Kar</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Pooley, Karen A" sort="Pooley, Karen A" uniqKey="Pooley K" first="Karen A" last="Pooley">Karen A. Pooley</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Lopez Knowles, Elena" sort="Lopez Knowles, Elena" uniqKey="Lopez Knowles E" first="Elena" last="Lopez-Knowles">Elena Lopez-Knowles</name><affiliation><nlm:aff id="A4">Breast Cancer Research, Breakthrough Breast Cancer Research Centre, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Academic Biochemistry, Royal Marsden Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Dicks, Ed" sort="Dicks, Ed" uniqKey="Dicks E" first="Ed" last="Dicks">Ed Dicks</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Barrowdale, Daniel" sort="Barrowdale, Daniel" uniqKey="Barrowdale D" first="Daniel" last="Barrowdale">Daniel Barrowdale</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Sinnott Armstrong, Nicholas A" sort="Sinnott Armstrong, Nicholas A" uniqKey="Sinnott Armstrong N" first="Nicholas A" last="Sinnott-Armstrong">Nicholas A. Sinnott-Armstrong</name><affiliation><nlm:aff id="A6">Department of Genetics, Stanford University School of Medicine, Stanford, California, USA</nlm:aff></affiliation></author><author><name sortKey="Sallari, Richard C" sort="Sallari, Richard C" uniqKey="Sallari R" first="Richard C" last="Sallari">Richard C. Sallari</name><affiliation><nlm:aff id="A7">Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Hillman, Kristine M" sort="Hillman, Kristine M" uniqKey="Hillman K" first="Kristine M" last="Hillman">Kristine M. Hillman</name><affiliation><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Kaufmann, Susanne" sort="Kaufmann, Susanne" uniqKey="Kaufmann S" first="Susanne" last="Kaufmann">Susanne Kaufmann</name><affiliation><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Sivakumaran, Haran" sort="Sivakumaran, Haran" uniqKey="Sivakumaran H" first="Haran" last="Sivakumaran">Haran Sivakumaran</name><affiliation><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Marjaneh, Mahdi Moradi" sort="Marjaneh, Mahdi Moradi" uniqKey="Marjaneh M" first="Mahdi Moradi" last="Marjaneh">Mahdi Moradi Marjaneh</name><affiliation><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Lee, Jason S" sort="Lee, Jason S" uniqKey="Lee J" first="Jason S" last="Lee">Jason S. Lee</name><affiliation><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Hills, Margaret" sort="Hills, Margaret" uniqKey="Hills M" first="Margaret" last="Hills">Margaret Hills</name><affiliation><nlm:aff id="A5">Academic Biochemistry, Royal Marsden Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Jarosz, Monika" sort="Jarosz, Monika" uniqKey="Jarosz M" first="Monika" last="Jarosz">Monika Jarosz</name><affiliation><nlm:aff id="A4">Breast Cancer Research, Breakthrough Breast Cancer Research Centre, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Academic Biochemistry, Royal Marsden Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Drury, Suzie" sort="Drury, Suzie" uniqKey="Drury S" first="Suzie" last="Drury">Suzie Drury</name><affiliation><nlm:aff id="A4">Breast Cancer Research, Breakthrough Breast Cancer Research Centre, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Academic Biochemistry, Royal Marsden Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Canisius, Sander" sort="Canisius, Sander" uniqKey="Canisius S" first="Sander" last="Canisius">Sander Canisius</name><affiliation><nlm:aff id="A8">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K" last="Bolla">Manjeet K. Bolla</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="A9">Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="A10">Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation><nlm:aff id="A8">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K" last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="A8">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name><affiliation><nlm:aff id="A11">Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK</nlm:aff></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation><nlm:aff id="A11">Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Institute of Population Health, University of Manchester, Manchester, UK</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W" last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="A13">Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg Metropolitan Region, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A" last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="A13">Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg Metropolitan Region, Erlangen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><affiliation><nlm:aff id="A15">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="A15">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J" last="Sawyer">Elinor J. Sawyer</name><affiliation><nlm:aff id="A16">Research Oncology, Division of Cancer Studies, King’s College London, Guy’s Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation><nlm:aff id="A17">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Oxford Biomedical Research Centre, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="A19">Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Molecular Epidemiology Group, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><affiliation><nlm:aff id="A21">National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation><nlm:aff id="A23">Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A24">University Paris–Sud, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation><nlm:aff id="A23">Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A24">University Paris–Sud, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E" last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="A25">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A26">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="A28">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name><affiliation><nlm:aff id="A29">Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Perez, Jose I A" sort="Perez, Jose I A" uniqKey="Perez J" first="Jose I A" last="Perez">Jose I A. Perez</name><affiliation><nlm:aff id="A30">Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain</nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="A31">Department of Epidemiology, University of California–Irvine, Irvine, California, USA</nlm:aff></affiliation></author><author><name sortKey="Eunjung, Lee" sort="Eunjung, Lee" uniqKey="Eunjung L" first="Lee" last="Eunjung">Lee Eunjung</name><affiliation><nlm:aff id="A32">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="A33">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="A33">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A34">German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="A35">Department of Gynaecology and Obstetrics, Technical University of Munich, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K" last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="A36">Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Centre of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Center for Integrated Oncology, University Hospital, Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="A34">German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A40">University of Tübingen, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="A41">Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="A42">Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation><nlm:aff id="A43">Department of Oncology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Ito, Hidemi" sort="Ito, Hidemi" uniqKey="Ito H" first="Hidemi" last="Ito">Hidemi Ito</name><affiliation><nlm:aff id="A44">Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Aichi, Japan</nlm:aff></affiliation></author><author><name sortKey="Matsuo, Keitaro" sort="Matsuo, Keitaro" uniqKey="Matsuo K" first="Keitaro" last="Matsuo">Keitaro Matsuo</name><affiliation><nlm:aff id="A45">Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan</nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natasha" sort="Bogdanova, Natasha" uniqKey="Bogdanova N" first="Natasha" last="Bogdanova">Natasha Bogdanova</name><affiliation><nlm:aff id="A46">Radiation Oncology Research Unit, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="A47">Gynaecology Research Unit, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff id="A48">Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation><nlm:aff id="A49">Department of Oncology-Pathology, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff id="A50">Cancer Center, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A51">Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff id="A50">Cancer Center, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A51">Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Tseng, Chiu Chen" sort="Tseng, Chiu Chen" uniqKey="Tseng C" first="Chiu-Chen" last="Tseng">Chiu-Chen Tseng</name><affiliation><nlm:aff id="A32">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Wu, Anna H" sort="Wu, Anna H" uniqKey="Wu A" first="Anna H" last="Wu">Anna H. Wu</name><affiliation><nlm:aff id="A32">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="A53">Vesalius Research Center, Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A54">Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Wildiers, Hans" sort="Wildiers, Hans" uniqKey="Wildiers H" first="Hans" last="Wildiers">Hans Wildiers</name><affiliation><nlm:aff id="A55">Multidisciplinary Breast Center, Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="A56">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A57">University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="A56">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="A58">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="A59">Unit of Molecular Basis of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E" last="Olson">Janet E. Olson</name><affiliation><nlm:aff id="A60">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="A9">Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L" last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="A9">Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A" last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="A32">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E" last="Henderson">Brian E. Henderson</name><affiliation><nlm:aff id="A32">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Goldberg, Mark S" sort="Goldberg, Mark S" uniqKey="Goldberg M" first="Mark S" last="Goldberg">Mark S. Goldberg</name><affiliation><nlm:aff id="A62">Department of Medicine, McGill University, Montreal, Quebec, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A63">Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Teo, Soo H" sort="Teo, Soo H" uniqKey="Teo S" first="Soo H" last="Teo">Soo H. Teo</name><affiliation><nlm:aff id="A64">Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Yip, Cheng Har" sort="Yip, Cheng Har" uniqKey="Yip C" first="Cheng Har" last="Yip">Cheng Har Yip</name><affiliation><nlm:aff id="A65">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Nord, Silje" sort="Nord, Silje" uniqKey="Nord S" first="Silje" last="Nord">Silje Nord</name><affiliation><nlm:aff id="A66">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Borresen Dale, Anne Lise" sort="Borresen Dale, Anne Lise" uniqKey="Borresen Dale A" first="Anne-Lise" last="Borresen-Dale">Anne-Lise Borresen-Dale</name><affiliation><nlm:aff id="A66">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A67">Institute of Clinical Medicine, University of Oslo, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation><nlm:aff id="A66">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A67">Institute of Clinical Medicine, University of Oslo, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A68">Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Long, Jirong" sort="Long, Jirong" uniqKey="Long J" first="Jirong" last="Long">Jirong Long</name><affiliation><nlm:aff id="A69">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA</nlm:aff></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:aff id="A69">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA</nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation><nlm:aff id="A70">Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A71">Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="A70">Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A71">Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L" last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="A72">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A73">Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A" last="Knight">Julia A. Knight</name><affiliation><nlm:aff id="A74">Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A75">Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:aff id="A76">Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A77">Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name><affiliation><nlm:aff id="A78">Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name><affiliation><nlm:aff id="A79">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Sherman, Mark E" sort="Sherman, Mark E" uniqKey="Sherman M" first="Mark E" last="Sherman">Mark E. Sherman</name><affiliation><nlm:aff id="A79">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="A80">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name><affiliation><nlm:aff id="A80">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation><nlm:aff id="A78">Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Den Ouweland, Ans M W" sort="Van Den Ouweland, Ans M W" uniqKey="Van Den Ouweland A" first="Ans M W" last="Van Den Ouweland">Ans M W. Van Den Ouweland</name><affiliation><nlm:aff id="A81">Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name><affiliation><nlm:aff id="A80">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Gao, Yu Tang" sort="Gao, Yu Tang" uniqKey="Gao Y" first="Yu-Tang" last="Gao">Yu-Tang Gao</name><affiliation><nlm:aff id="A82">Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China</nlm:aff></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation><nlm:aff id="A69">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="A83">Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S" last="Cross">Simon S. Cross</name><affiliation><nlm:aff id="A84">Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Blot, William" sort="Blot, William" uniqKey="Blot W" first="William" last="Blot">William Blot</name><affiliation><nlm:aff id="A69">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A85">International Epidemiology Institute, Rockville, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Cai, Qiuyin" sort="Cai, Qiuyin" uniqKey="Cai Q" first="Qiuyin" last="Cai">Qiuyin Cai</name><affiliation><nlm:aff id="A69">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA</nlm:aff></affiliation></author><author><name sortKey="Ghoussaini, Maya" sort="Ghoussaini, Maya" uniqKey="Ghoussaini M" first="Maya" last="Ghoussaini">Maya Ghoussaini</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Perkins, Barbara J" sort="Perkins, Barbara J" uniqKey="Perkins B" first="Barbara J" last="Perkins">Barbara J. Perkins</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Choi, Ji Yeob" sort="Choi, Ji Yeob" uniqKey="Choi J" first="Ji-Yeob" last="Choi">Ji-Yeob Choi</name><affiliation><nlm:aff id="A86">Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A87">Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Kang, Daehee" sort="Kang, Daehee" uniqKey="Kang D" first="Daehee" last="Kang">Daehee Kang</name><affiliation><nlm:aff id="A86">Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A87">Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A88">Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Lee, Soo Chin" sort="Lee, Soo Chin" uniqKey="Lee S" first="Soo Chin" last="Lee">Soo Chin Lee</name><affiliation><nlm:aff id="A89">Department of Haematology-Oncology, National University Health System, Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="A90">Cancer Science Institute of Singapore, National University of Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Hartman, Mikael" sort="Hartman, Mikael" uniqKey="Hartman M" first="Mikael" last="Hartman">Mikael Hartman</name><affiliation><nlm:aff id="A91">Saw Swee Hock School of Public Health, National University of Singapore, Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="A92">Department of Surgery, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Kabisch, Maria" sort="Kabisch, Maria" uniqKey="Kabisch M" first="Maria" last="Kabisch">Maria Kabisch</name><affiliation><nlm:aff id="A41">Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name><affiliation><nlm:aff id="A41">Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A93">Institute of Human Genetics, Pontificia Universidad Javerianar, Bogota, Colombia</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="A94">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="A94">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation><nlm:aff id="A95">International Agency for Research on Cancer, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Sangrajrang, Suleeporn" sort="Sangrajrang, Suleeporn" uniqKey="Sangrajrang S" first="Suleeporn" last="Sangrajrang">Suleeporn Sangrajrang</name><affiliation><nlm:aff id="A96">National Cancer Institute, Bangkok, Thailand</nlm:aff></affiliation></author><author><name sortKey="Ambrosone, Christine B" sort="Ambrosone, Christine B" uniqKey="Ambrosone C" first="Christine B" last="Ambrosone">Christine B. Ambrosone</name><affiliation><nlm:aff id="A97">Roswell Park Cancer Institute, Buffalo, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E" last="Toland">Amanda E. Toland</name><affiliation><nlm:aff id="A98">Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA</nlm:aff></affiliation></author><author><name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name><affiliation><nlm:aff id="A99">School of Public Health, China Medical University, Taichung, Taiwan</nlm:aff></affiliation><affiliation><nlm:aff id="A100">Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Wu, Pei Ei" sort="Wu, Pei Ei" uniqKey="Wu P" first="Pei-Ei" last="Wu">Pei-Ei Wu</name><affiliation><nlm:aff id="A100">Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><affiliation><nlm:aff id="A101">Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation><nlm:aff id="A102">Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A103">Division of Breast Cancer Research, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name><affiliation><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Lee, Andrew" sort="Lee, Andrew" uniqKey="Lee A" first="Andrew" last="Lee">Andrew Lee</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Kapuscinski, Miroslav" sort="Kapuscinski, Miroslav" uniqKey="Kapuscinski M" first="Miroslav" last="Kapuscinski">Miroslav Kapuscinski</name><affiliation><nlm:aff id="A104">Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M" last="John">Esther M. John</name><affiliation><nlm:aff id="A105">Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California, USA</nlm:aff></affiliation></author><author><name sortKey="Terry, Mary Beth" sort="Terry, Mary Beth" uniqKey="Terry M" first="Mary Beth" last="Terry">Mary Beth Terry</name><affiliation><nlm:aff id="A106">Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B" last="Daly">Mary B. Daly</name><affiliation><nlm:aff id="A107">Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E" last="Goldgar">David E. Goldgar</name><affiliation><nlm:aff id="A108">Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA</nlm:aff></affiliation></author><author><name sortKey="Buys, Saundra S" sort="Buys, Saundra S" uniqKey="Buys S" first="Saundra S" last="Buys">Saundra S. Buys</name><affiliation><nlm:aff id="A109">Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA</nlm:aff></affiliation></author><author><name sortKey="Janavicius, Ramunas" sort="Janavicius, Ramunas" uniqKey="Janavicius R" first="Ramunas" last="Janavicius">Ramunas Janavicius</name><affiliation><nlm:aff id="A110">State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania</nlm:aff></affiliation></author><author><name sortKey="Tihomirova, Laima" sort="Tihomirova, Laima" uniqKey="Tihomirova L" first="Laima" last="Tihomirova">Laima Tihomirova</name><affiliation><nlm:aff id="A111">Latvian Biomedical Research and Study Centre, Riga, Latvia</nlm:aff></affiliation></author><author><name sortKey="Tung, Nadine" sort="Tung, Nadine" uniqKey="Tung N" first="Nadine" last="Tung">Nadine Tung</name><affiliation><nlm:aff id="A112">Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Dorfling, Cecilia M" sort="Dorfling, Cecilia M" uniqKey="Dorfling C" first="Cecilia M" last="Dorfling">Cecilia M. Dorfling</name><affiliation><nlm:aff id="A113">Department of Genetics, University of Pretoria, Pretoria, South Africa</nlm:aff></affiliation></author><author><name sortKey="Van Rensburg, Elizabeth J" sort="Van Rensburg, Elizabeth J" uniqKey="Van Rensburg E" first="Elizabeth J" last="Van Rensburg">Elizabeth J. Van Rensburg</name><affiliation><nlm:aff id="A113">Department of Genetics, University of Pretoria, Pretoria, South Africa</nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L" last="Neuhausen">Susan L. Neuhausen</name><affiliation><nlm:aff id="A114">Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, USA</nlm:aff></affiliation></author><author><name sortKey="Ejlertsen, Bent" sort="Ejlertsen, Bent" uniqKey="Ejlertsen B" first="Bent" last="Ejlertsen">Bent Ejlertsen</name><affiliation><nlm:aff id="A115">Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Hansen, Thomas V O" sort="Hansen, Thomas V O" uniqKey="Hansen T" first="Thomas V O" last="Hansen">Thomas V O. Hansen</name><affiliation><nlm:aff id="A116">Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name><affiliation><nlm:aff id="A117">Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A118">Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="A117">Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A118">Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A119">Human Genotyping (CEGEN) Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Rando, Rachel" sort="Rando, Rachel" uniqKey="Rando R" first="Rachel" last="Rando">Rachel Rando</name><affiliation><nlm:aff id="A120">City of Hope Clinical Cancer Genomics Community Research Network, Duarte, California, USA</nlm:aff></affiliation></author><author><name sortKey="Weitzel, Jeffrey N" sort="Weitzel, Jeffrey N" uniqKey="Weitzel J" first="Jeffrey N" last="Weitzel">Jeffrey N. Weitzel</name><affiliation><nlm:aff id="A121">Clinical Cancer Genetics, City of Hope, Duarte, California, USA</nlm:aff></affiliation></author><author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name><affiliation><nlm:aff id="A122">Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Peissel, Bernard" sort="Peissel, Bernard" uniqKey="Peissel B" first="Bernard" last="Peissel">Bernard Peissel</name><affiliation><nlm:aff id="A123">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale Tumori, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="A123">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale Tumori, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Papi, Laura" sort="Papi, Laura" uniqKey="Papi L" first="Laura" last="Papi">Laura Papi</name><affiliation><nlm:aff id="A124">Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Ottini, Laura" sort="Ottini, Laura" uniqKey="Ottini L" first="Laura" last="Ottini">Laura Ottini</name><affiliation><nlm:aff id="A125">Department of Molecular Medicine, University La Sapienza, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Konstantopoulou, Irene" sort="Konstantopoulou, Irene" uniqKey="Konstantopoulou I" first="Irene" last="Konstantopoulou">Irene Konstantopoulou</name><affiliation><nlm:aff id="A126">Molecular Diagnostics Laboratory, INRASTES (Institute of Nuclear and Radiological Sciences and Technology), National Centre for Scientific Research ‘Demokritos’, Aghia Paraskevi Attikis, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Apostolou, Paraskevi" sort="Apostolou, Paraskevi" uniqKey="Apostolou P" first="Paraskevi" last="Apostolou">Paraskevi Apostolou</name><affiliation><nlm:aff id="A126">Molecular Diagnostics Laboratory, INRASTES (Institute of Nuclear and Radiological Sciences and Technology), National Centre for Scientific Research ‘Demokritos’, Aghia Paraskevi Attikis, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Garber, Judy" sort="Garber, Judy" uniqKey="Garber J" first="Judy" last="Garber">Judy Garber</name><affiliation><nlm:aff id="A127">Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Rashid, Muhammad Usman" sort="Rashid, Muhammad Usman" uniqKey="Rashid M" first="Muhammad Usman" last="Rashid">Muhammad Usman Rashid</name><affiliation><nlm:aff id="A41">Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A128">Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan</nlm:aff></affiliation></author><author><name sortKey="Frost, Debra" sort="Frost, Debra" uniqKey="Frost D" first="Debra" last="Frost">Debra Frost</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Izatt, Louise" sort="Izatt, Louise" uniqKey="Izatt L" first="Louise" last="Izatt">Louise Izatt</name><affiliation><nlm:aff id="A129">Clinical Genetics, Guy’s and St. Thomas’ National Health Service (NHS) Foundation Trust, London, UK</nlm:aff></affiliation></author><author><name sortKey="Ellis, Steve" sort="Ellis, Steve" uniqKey="Ellis S" first="Steve" last="Ellis">Steve Ellis</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K" last="Godwin">Andrew K. Godwin</name><affiliation><nlm:aff id="A130">Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA</nlm:aff></affiliation></author><author><name sortKey="Arnold, Norbert" sort="Arnold, Norbert" uniqKey="Arnold N" first="Norbert" last="Arnold">Norbert Arnold</name><affiliation><nlm:aff id="A131">Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian Albrechts University Kiel, Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Niederacher, Dieter" sort="Niederacher, Dieter" uniqKey="Niederacher D" first="Dieter" last="Niederacher">Dieter Niederacher</name><affiliation><nlm:aff id="A132">University Düsseldorf, Dusseldorf, Germany</nlm:aff></affiliation></author><author><name sortKey="Rhiem, Kerstin" sort="Rhiem, Kerstin" uniqKey="Rhiem K" first="Kerstin" last="Rhiem">Kerstin Rhiem</name><affiliation><nlm:aff id="A133">Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology, Center for Molecular Medicine Cologne, University Hospital of Cologne, Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Bogdanova Markov, Nadja" sort="Bogdanova Markov, Nadja" uniqKey="Bogdanova Markov N" first="Nadja" last="Bogdanova-Markov">Nadja Bogdanova-Markov</name><affiliation><nlm:aff id="A134">Institute of Human Genetics, Münster, Germany</nlm:aff></affiliation></author><author><name sortKey="Sagne, Charlotte" sort="Sagne, Charlotte" uniqKey="Sagne C" first="Charlotte" last="Sagne">Charlotte Sagne</name><affiliation><nlm:aff id="A135">INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><affiliation><nlm:aff id="A136">Institut Curie, Department of Tumour Biology, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A137">Université Paris Descartes, Sorbonne Paris Cité, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Damiola, Francesca" sort="Damiola, Francesca" uniqKey="Damiola F" first="Francesca" last="Damiola">Francesca Damiola</name><affiliation><nlm:aff id="A135">INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M" last="Sinilnikova">Olga M. Sinilnikova</name><affiliation><nlm:aff id="A135">INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="A138">Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon–Centre Léon Bérard, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name><affiliation><nlm:aff id="A135">INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Isaacs, Claudine" sort="Isaacs, Claudine" uniqKey="Isaacs C" first="Claudine" last="Isaacs">Claudine Isaacs</name><affiliation><nlm:aff id="A139">Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA</nlm:aff></affiliation></author><author><name sortKey="Claes, Kathleen B M" sort="Claes, Kathleen B M" uniqKey="Claes K" first="Kathleen B M" last="Claes">Kathleen B M. Claes</name><affiliation><nlm:aff id="A140">Center for Medical Genetics, Ghent University, Ghent, Belgium</nlm:aff></affiliation></author><author><name sortKey="De Leeneer, Kim" sort="De Leeneer, Kim" uniqKey="De Leeneer K" first="Kim" last="De Leeneer">Kim De Leeneer</name><affiliation><nlm:aff id="A140">Center for Medical Genetics, Ghent University, Ghent, Belgium</nlm:aff></affiliation></author><author><name sortKey="De La Hoya, Miguel" sort="De La Hoya, Miguel" uniqKey="De La Hoya M" first="Miguel" last="De La Hoya">Miguel De La Hoya</name><affiliation><nlm:aff id="A141">Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Caldes, Trinidad" sort="Caldes, Trinidad" uniqKey="Caldes T" first="Trinidad" last="Caldes">Trinidad Caldes</name><affiliation><nlm:aff id="A141">Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="A142">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Khan, Sofia" sort="Khan, Sofia" uniqKey="Khan S" first="Sofia" last="Khan">Sofia Khan</name><affiliation><nlm:aff id="A142">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Mensenkamp, Arjen R" sort="Mensenkamp, Arjen R" uniqKey="Mensenkamp A" first="Arjen R" last="Mensenkamp">Arjen R. Mensenkamp</name><affiliation><nlm:aff id="A143">Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J" last="Hooning">Maartje J. Hooning</name><affiliation><nlm:aff id="A144">Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Rookus, Matti A" sort="Rookus, Matti A" uniqKey="Rookus M" first="Matti A" last="Rookus">Matti A. Rookus</name><affiliation><nlm:aff id="A145">Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kwong, Ava" sort="Kwong, Ava" uniqKey="Kwong A" first="Ava" last="Kwong">Ava Kwong</name><affiliation><nlm:aff id="A146">Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong</nlm:aff></affiliation><affiliation><nlm:aff id="A147">Department of Surgery, University of Hong Kong, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Olah, Edith" sort="Olah, Edith" uniqKey="Olah E" first="Edith" last="Olah">Edith Olah</name><affiliation><nlm:aff id="A148">Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary</nlm:aff></affiliation></author><author><name sortKey="Diez, Orland" sort="Diez, Orland" uniqKey="Diez O" first="Orland" last="Diez">Orland Diez</name><affiliation><nlm:aff id="A149">Oncogenetics Laboratory, Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron University Hospital, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Brunet, Joan" sort="Brunet, Joan" uniqKey="Brunet J" first="Joan" last="Brunet">Joan Brunet</name><affiliation><nlm:aff id="A150">Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d’Investigació Biomèdica de Girona), Catalan Institute of Oncology, Girona, Spain</nlm:aff></affiliation></author><author><name sortKey="Pujana, Miquel Angel" sort="Pujana, Miquel Angel" uniqKey="Pujana M" first="Miquel Angel" last="Pujana">Miquel Angel Pujana</name><affiliation><nlm:aff id="A151">Breast Cancer and Systems Biology Unit, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Gronwald, Jacek" sort="Gronwald, Jacek" uniqKey="Gronwald J" first="Jacek" last="Gronwald">Jacek Gronwald</name><affiliation><nlm:aff id="A94">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Huzarski, Tomasz" sort="Huzarski, Tomasz" uniqKey="Huzarski T" first="Tomasz" last="Huzarski">Tomasz Huzarski</name><affiliation><nlm:aff id="A94">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Barkardottir, Rosa B" sort="Barkardottir, Rosa B" uniqKey="Barkardottir R" first="Rosa B" last="Barkardottir">Rosa B. Barkardottir</name><affiliation><nlm:aff id="A152">Department of Pathology, Landspitali University Hospital and Biomedical Centre (BMC), Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Laframboise, Rachel" sort="Laframboise, Rachel" uniqKey="Laframboise R" first="Rachel" last="Laframboise">Rachel Laframboise</name><affiliation><nlm:aff id="A153">Medical Genetic Division, Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name><affiliation><nlm:aff id="A154">Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name><affiliation><nlm:aff id="A155">Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV), IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Padua, Italy</nlm:aff></affiliation></author><author><name sortKey="Agata, Simona" sort="Agata, Simona" uniqKey="Agata S" first="Simona" last="Agata">Simona Agata</name><affiliation><nlm:aff id="A155">Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV), IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Padua, Italy</nlm:aff></affiliation></author><author><name sortKey="Teixeira, Manuel R" sort="Teixeira, Manuel R" uniqKey="Teixeira M" first="Manuel R" last="Teixeira">Manuel R. Teixeira</name><affiliation><nlm:aff id="A156">Department of Genetics, Portuguese Oncology Institute, Porto, Portugal</nlm:aff></affiliation><affiliation><nlm:aff id="A157">Biomedical Sciences Institute (ICBAS), Porto University, Porto, Portugal</nlm:aff></affiliation></author><author><name sortKey="Park, Sue Kyung" sort="Park, Sue Kyung" uniqKey="Park S" first="Sue Kyung" last="Park">Sue Kyung Park</name><affiliation><nlm:aff id="A86">Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A87">Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A88">Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Lindor, Noralane" sort="Lindor, Noralane" uniqKey="Lindor N" first="Noralane" last="Lindor">Noralane Lindor</name><affiliation><nlm:aff id="A60">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J" last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="A60">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A158">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Tischkowitz, Marc" sort="Tischkowitz, Marc" uniqKey="Tischkowitz M" first="Marc" last="Tischkowitz">Marc Tischkowitz</name><affiliation><nlm:aff id="A159">Program in Cancer Genetics, McGill University, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Foretova, Lenka" sort="Foretova, Lenka" uniqKey="Foretova L" first="Lenka" last="Foretova">Lenka Foretova</name><affiliation><nlm:aff id="A160">Masaryk Memorial Cancer Institute and Medical Faculty, Masaryk University, Brno, Czech Republic</nlm:aff></affiliation></author><author><name sortKey="Vijai, Joseph" sort="Vijai, Joseph" uniqKey="Vijai J" first="Joseph" last="Vijai">Joseph Vijai</name><affiliation><nlm:aff id="A161">Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation><nlm:aff id="A161">Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Singer, Christian F" sort="Singer, Christian F" uniqKey="Singer C" first="Christian F" last="Singer">Christian F. Singer</name><affiliation><nlm:aff id="A162">Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Rappaport, Christine" sort="Rappaport, Christine" uniqKey="Rappaport C" first="Christine" last="Rappaport">Christine Rappaport</name><affiliation><nlm:aff id="A162">Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Phelan, Catherine M" sort="Phelan, Catherine M" uniqKey="Phelan C" first="Catherine M" last="Phelan">Catherine M. Phelan</name><affiliation><nlm:aff id="A163">Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA</nlm:aff></affiliation></author><author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H" last="Greene">Mark H. Greene</name><affiliation><nlm:aff id="A164">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Rockville, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L" last="Mai">Phuong L. Mai</name><affiliation><nlm:aff id="A164">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Rockville, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name><affiliation><nlm:aff id="A165">Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Haifa, Israel</nlm:aff></affiliation><affiliation><nlm:aff id="A166">Clalit National Israeli Cancer Control Center, Haifa, Israel</nlm:aff></affiliation></author><author><name sortKey="Imyanitov, Evgeny N" sort="Imyanitov, Evgeny N" uniqKey="Imyanitov E" first="Evgeny N" last="Imyanitov">Evgeny N. Imyanitov</name><affiliation><nlm:aff id="A167">N.N. Petrov Institute of Oncology, St. Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Hulick, Peter J" sort="Hulick, Peter J" uniqKey="Hulick P" first="Peter J" last="Hulick">Peter J. Hulick</name><affiliation><nlm:aff id="A168">Center for Medical Genetics, NorthShore University Health System, Evanston, Illinois, USA</nlm:aff></affiliation></author><author><name sortKey="Phillips, Kelly Anne" sort="Phillips, Kelly Anne" uniqKey="Phillips K" first="Kelly-Anne" last="Phillips">Kelly-Anne Phillips</name><affiliation><nlm:aff id="A169">Division of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Piedmonte, Marion" sort="Piedmonte, Marion" uniqKey="Piedmonte M" first="Marion" last="Piedmonte">Marion Piedmonte</name><affiliation><nlm:aff id="A170">NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation><nlm:aff id="A171">Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A172">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="A72">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Anders" sort="Bojesen, Anders" uniqKey="Bojesen A" first="Anders" last="Bojesen">Anders Bojesen</name><affiliation><nlm:aff id="A173">Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark</nlm:aff></affiliation></author><author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name><affiliation><nlm:aff id="A174">Department of Clinical Genetics, Odense University Hospital, Odense, Denmark</nlm:aff></affiliation></author><author><name sortKey="Caligo, Maria A" sort="Caligo, Maria A" uniqKey="Caligo M" first="Maria A" last="Caligo">Maria A. Caligo</name><affiliation><nlm:aff id="A175">Section of Genetic Oncology, Department of Laboratory Medicine, University of Pisa and University Hospital of Pisa, Pisa, Italy</nlm:aff></affiliation></author><author><name sortKey="Yoon, Sook Yee" sort="Yoon, Sook Yee" uniqKey="Yoon S" first="Sook-Yee" last="Yoon">Sook-Yee Yoon</name><affiliation><nlm:aff id="A64">Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia</nlm:aff></affiliation><affiliation><nlm:aff id="A176">University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name><affiliation><nlm:aff id="A177">Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel</nlm:aff></affiliation></author><author><name sortKey="Laitman, Yael" sort="Laitman, Yael" uniqKey="Laitman Y" first="Yael" last="Laitman">Yael Laitman</name><affiliation><nlm:aff id="A177">Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel</nlm:aff></affiliation></author><author><name sortKey="Borg, Ake" sort="Borg, Ake" uniqKey="Borg A" first="Ake" last="Borg">Ake Borg</name><affiliation><nlm:aff id="A178">Department of Oncology, Lund University, Lund, Sweden</nlm:aff></affiliation></author><author><name sortKey="Von Wachenfeldt, Anna" sort="Von Wachenfeldt, Anna" uniqKey="Von Wachenfeldt A" first="Anna" last="Von Wachenfeldt">Anna Von Wachenfeldt</name><affiliation><nlm:aff id="A49">Department of Oncology-Pathology, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Ehrencrona, Hans" sort="Ehrencrona, Hans" uniqKey="Ehrencrona H" first="Hans" last="Ehrencrona">Hans Ehrencrona</name><affiliation><nlm:aff id="A179">Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A180">Department of Clinical Genetics, Lund University Hospital, Lund, Sweden</nlm:aff></affiliation></author><author><name sortKey="Rantala, Johanna" sort="Rantala, Johanna" uniqKey="Rantala J" first="Johanna" last="Rantala">Johanna Rantala</name><affiliation><nlm:aff id="A181">Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Olopade, Olufunmilayo I" sort="Olopade, Olufunmilayo I" uniqKey="Olopade O" first="Olufunmilayo I" last="Olopade">Olufunmilayo I. Olopade</name><affiliation><nlm:aff id="A182">Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, Illinois, USA</nlm:aff></affiliation></author><author><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A" last="Ganz">Patricia A. Ganz</name><affiliation><nlm:aff id="A183">Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center, University of California Los Angeles School of Medicine and School of Public Health, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Nussbaum, Robert L" sort="Nussbaum, Robert L" uniqKey="Nussbaum R" first="Robert L" last="Nussbaum">Robert L. Nussbaum</name><affiliation><nlm:aff id="A184">Department of Medicine and Genetics, University of California, San Francisco, San Francisco, California, USA</nlm:aff></affiliation></author><author><name sortKey="Gayther, Simon A" sort="Gayther, Simon A" uniqKey="Gayther S" first="Simon A" last="Gayther">Simon A. Gayther</name><affiliation><nlm:aff id="A32">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L" last="Nathanson">Katherine L. Nathanson</name><affiliation><nlm:aff id="A185">Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M" last="Domchek">Susan M. Domchek</name><affiliation><nlm:aff id="A185">Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Arun, Banu K" sort="Arun, Banu K" uniqKey="Arun B" first="Banu K" last="Arun">Banu K. Arun</name><affiliation><nlm:aff id="A186">University of Texas MD Anderson Cancer Center, Houston, Texas, USA</nlm:aff></affiliation></author><author><name sortKey="Mitchell, Gillian" sort="Mitchell, Gillian" uniqKey="Mitchell G" first="Gillian" last="Mitchell">Gillian Mitchell</name><affiliation><nlm:aff id="A187">Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A188">Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Karlan, Beth Y" sort="Karlan, Beth Y" uniqKey="Karlan B" first="Beth Y" last="Karlan">Beth Y. Karlan</name><affiliation><nlm:aff id="A189">Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Lester, Jenny" sort="Lester, Jenny" uniqKey="Lester J" first="Jenny" last="Lester">Jenny Lester</name><affiliation><nlm:aff id="A189">Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Maskarinec, Gertraud" sort="Maskarinec, Gertraud" uniqKey="Maskarinec G" first="Gertraud" last="Maskarinec">Gertraud Maskarinec</name><affiliation><nlm:aff id="A190">University of Hawaii Cancer Center, Honolulu, Hawaii, USA</nlm:aff></affiliation></author><author><name sortKey="Woolcott, Christy" sort="Woolcott, Christy" uniqKey="Woolcott C" first="Christy" last="Woolcott">Christy Woolcott</name><affiliation><nlm:aff id="A191">Department of Obstetrics, Gynaecology and Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada</nlm:aff></affiliation></author><author><name sortKey="Scott, Christopher" sort="Scott, Christopher" uniqKey="Scott C" first="Christopher" last="Scott">Christopher Scott</name><affiliation><nlm:aff id="A60">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Stone, Jennifer" sort="Stone, Jennifer" uniqKey="Stone J" first="Jennifer" last="Stone">Jennifer Stone</name><affiliation><nlm:aff id="A192">Centre for Genetic Origins of Health and Disease, University of Western Australia, Perth, Western Australia, Australia</nlm:aff></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation><nlm:aff id="A9">Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Tamimi, Rulla" sort="Tamimi, Rulla" uniqKey="Tamimi R" first="Rulla" last="Tamimi">Rulla Tamimi</name><affiliation><nlm:aff id="A193">Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A194">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A195">Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Luben, Robert" sort="Luben, Robert" uniqKey="Luben R" first="Robert" last="Luben">Robert Luben</name><affiliation><nlm:aff id="A196">Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation><nlm:aff id="A196">Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Helland, Slaug" sort="Helland, Slaug" uniqKey="Helland " first=" Slaug" last="Helland"> Slaug Helland</name><affiliation><nlm:aff id="A66">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Haakensen, Vilde" sort="Haakensen, Vilde" uniqKey="Haakensen V" first="Vilde" last="Haakensen">Vilde Haakensen</name><affiliation><nlm:aff id="A66">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Dowsett, Mitch" sort="Dowsett, Mitch" uniqKey="Dowsett M" first="Mitch" last="Dowsett">Mitch Dowsett</name><affiliation><nlm:aff id="A4">Breast Cancer Research, Breakthrough Breast Cancer Research Centre, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Academic Biochemistry, Royal Marsden Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D P" last="Pharoah">Paul D P. Pharoah</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="A154">Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="A80">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation><nlm:aff id="A101">Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A102">Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name><affiliation><nlm:aff id="A60">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C" last="Antoniou">Antonis C. Antoniou</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F" last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Edwards, Stacey L" sort="Edwards, Stacey L" uniqKey="Edwards S" first="Stacey L" last="Edwards">Stacey L. Edwards</name><affiliation><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">We analyzed 3,872 common genetic variants across the
<italic>ESR1</italic> locus (encoding estrogen receptor α) in
118,816 subjects from three international consortia. We found evidence for at
least five independent causal variants, each associated with different phenotype
sets, including estrogen receptor (ER<sup>+</sup> or
ER<sup>−</sup>) and human ERBB2 (HER2<sup>+</sup> or
HER2<sup>−</sup>) tumor subtypes, mammographic density and tumor
grade. The best candidate causal variants for ER<sup>−</sup> tumors lie
in four separate enhancer elements, and their risk alleles reduce expression of
<italic>ESR1</italic>, <italic>RMND1</italic> and <italic>CCDC170</italic>,
whereas the risk alleles of the strongest candidates for the remaining
independent causal variant disrupt a silencer element and putatively increase
<italic>ESR1</italic> and <italic>RMND1</italic> expression.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9216904</journal-id><journal-id journal-id-type="pubmed-jr-id">2419</journal-id><journal-id journal-id-type="nlm-ta">Nat Genet</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Genet.</journal-id><journal-title-group><journal-title>Nature genetics</journal-title></journal-title-group><issn pub-type="ppub">1061-4036</issn><issn pub-type="epub">1546-1718</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26928228</article-id><article-id pub-id-type="pmc">4938803</article-id><article-id pub-id-type="doi">10.1038/ng.3521</article-id><article-id pub-id-type="manuscript">NIHMS783876</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Breast cancer risk variants at 6q25 display different phenotype
associations and regulate <italic>ESR1</italic>, <italic>RMND1</italic> and
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rid="A180">181</xref></contrib><contrib contrib-type="author"><name><surname>Rantala</surname><given-names>Johanna</given-names></name><xref ref-type="aff" rid="A181">182</xref></contrib><contrib contrib-type="author"><name><surname>Olopade</surname><given-names>Olufunmilayo I</given-names></name><xref ref-type="aff" rid="A182">183</xref></contrib><contrib contrib-type="author"><name><surname>Ganz</surname><given-names>Patricia A</given-names></name><xref ref-type="aff" rid="A183">184</xref></contrib><contrib contrib-type="author"><name><surname>Nussbaum</surname><given-names>Robert L</given-names></name><xref ref-type="aff" rid="A184">185</xref></contrib><contrib contrib-type="author"><name><surname>Gayther</surname><given-names>Simon A</given-names></name><xref ref-type="aff" rid="A32">32</xref></contrib><contrib contrib-type="author"><name><surname>Nathanson</surname><given-names>Katherine L</given-names></name><xref ref-type="aff" rid="A185">186</xref></contrib><contrib 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rid="A154">155</xref></contrib><contrib contrib-type="author"><name><surname>Hall</surname><given-names>Per</given-names></name><xref ref-type="aff" rid="A80">80</xref></contrib><contrib contrib-type="author"><name><surname>García-Closas</surname><given-names>Montserrat</given-names></name><xref ref-type="aff" rid="A101">101</xref><xref ref-type="aff" rid="A102">102</xref></contrib><contrib contrib-type="author"><name><surname>Vachon</surname><given-names>Celine</given-names></name><xref ref-type="aff" rid="A60">60</xref></contrib><contrib contrib-type="author"><name><surname>Chenevix-Trench</surname><given-names>Georgia</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Antoniou</surname><given-names>Antonis C</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref rid="FN4" ref-type="author-notes">199</xref></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas F</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref rid="FN4" ref-type="author-notes">199</xref></contrib><contrib contrib-type="author"><name><surname>Edwards</surname><given-names>Stacey L</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref rid="FN4" ref-type="author-notes">199</xref></contrib></contrib-group><aff id="A1"><label>1</label>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</aff><aff id="A2"><label>2</label>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</aff><aff id="A3"><label>3</label>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</aff><aff id="A4"><label>4</label>Breast Cancer Research, Breakthrough Breast Cancer Research Centre, London, UK</aff><aff id="A5"><label>5</label>Academic Biochemistry, Royal Marsden Hospital, London, UK</aff><aff id="A6"><label>6</label>Department of Genetics, Stanford University School of Medicine, Stanford, California, USA</aff><aff id="A7"><label>7</label>Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA</aff><aff id="A8"><label>8</label>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands</aff><aff id="A9"><label>9</label>Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia</aff><aff id="A10"><label>10</label>Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia</aff><aff id="A11"><label>11</label>Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK</aff><aff id="A12"><label>12</label>Institute of Population Health, University of Manchester, Manchester, UK</aff><aff id="A13"><label>13</label>Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg Metropolitan Region, Erlangen, Germany</aff><aff id="A14"><label>14</label>Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA</aff><aff id="A15"><label>15</label>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</aff><aff id="A16"><label>16</label>Research Oncology, Division of Cancer Studies, King’s College London, Guy’s Hospital, London, UK</aff><aff id="A17"><label>17</label>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</aff><aff id="A18"><label>18</label>Oxford Biomedical Research Centre, University of Oxford, Oxford, UK</aff><aff id="A19"><label>19</label>Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A20"><label>20</label>Molecular Epidemiology Group, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A21"><label>21</label>National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</aff><aff id="A22"><label>22</label>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</aff><aff id="A23"><label>23</label>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</aff><aff id="A24"><label>24</label>University Paris–Sud, Villejuif, France</aff><aff id="A25"><label>25</label>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</aff><aff id="A26"><label>26</label>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</aff><aff id="A27"><label>27</label>Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</aff><aff id="A28"><label>28</label>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</aff><aff id="A29"><label>29</label>Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, Spain</aff><aff id="A30"><label>30</label>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain</aff><aff id="A31"><label>31</label>Department of Epidemiology, University of California–Irvine, Irvine, California, USA</aff><aff id="A32"><label>32</label>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA</aff><aff id="A33"><label>33</label>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A34"><label>34</label>German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A35"><label>35</label>Department of Gynaecology and Obstetrics, Technical University of Munich, Munich, Germany</aff><aff id="A36"><label>36</label>Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany</aff><aff id="A37"><label>37</label>Centre of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany</aff><aff id="A38"><label>38</label>Center for Integrated Oncology, University Hospital, Cologne, Germany</aff><aff id="A39"><label>39</label>Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany</aff><aff id="A40"><label>40</label>University of Tübingen, Tübingen, Germany</aff><aff id="A41"><label>41</label>Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A42"><label>42</label>Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland</aff><aff id="A43"><label>43</label>Department of Oncology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland</aff><aff id="A44"><label>44</label>Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Aichi, Japan</aff><aff id="A45"><label>45</label>Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan</aff><aff id="A46"><label>46</label>Radiation Oncology Research Unit, Hannover Medical School, Hannover, Germany</aff><aff id="A47"><label>47</label>Gynaecology Research Unit, Hannover Medical School, Hannover, Germany</aff><aff id="A48"><label>48</label>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A49"><label>49</label>Department of Oncology-Pathology, Karolinska University Hospital, Stockholm, Sweden</aff><aff id="A50"><label>50</label>Cancer Center, Kuopio University Hospital, Kuopio, Finland</aff><aff id="A51"><label>51</label>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</aff><aff id="A52"><label>52</label>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</aff><aff id="A53"><label>53</label>Vesalius Research Center, Leuven, Belgium</aff><aff id="A54"><label>54</label>Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</aff><aff id="A55"><label>55</label>Multidisciplinary Breast Center, Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium</aff><aff id="A56"><label>56</label>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A57"><label>57</label>University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany</aff><aff id="A58"><label>58</label>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</aff><aff id="A59"><label>59</label>Unit of Molecular Basis of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy</aff><aff id="A60"><label>60</label>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</aff><aff id="A61"><label>61</label>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia</aff><aff id="A62"><label>62</label>Department of Medicine, McGill University, Montreal, Quebec, Canada</aff><aff id="A63"><label>63</label>Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada</aff><aff id="A64"><label>64</label>Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia</aff><aff id="A65"><label>65</label>Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia</aff><aff id="A66"><label>66</label>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</aff><aff id="A67"><label>67</label>Institute of Clinical Medicine, University of Oslo, Oslo, Norway</aff><aff id="A68"><label>68</label>Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway</aff><aff id="A69"><label>69</label>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA</aff><aff id="A70"><label>70</label>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu University Hospital, Oulu, Finland</aff><aff id="A71"><label>71</label>Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland</aff><aff id="A72"><label>72</label>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada</aff><aff id="A73"><label>73</label>Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</aff><aff id="A74"><label>74</label>Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada</aff><aff id="A75"><label>75</label>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada</aff><aff id="A76"><label>76</label>Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands</aff><aff id="A77"><label>77</label>Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands</aff><aff id="A78"><label>78</label>Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, the Netherlands</aff><aff id="A79"><label>79</label>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA</aff><aff id="A80"><label>80</label>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A81"><label>81</label>Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands</aff><aff id="A82"><label>82</label>Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China</aff><aff id="A83"><label>83</label>Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield, UK</aff><aff id="A84"><label>84</label>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK</aff><aff id="A85"><label>85</label>International Epidemiology Institute, Rockville, Maryland, USA</aff><aff id="A86"><label>86</label>Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea</aff><aff id="A87"><label>87</label>Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea</aff><aff id="A88"><label>88</label>Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea</aff><aff id="A89"><label>89</label>Department of Haematology-Oncology, National University Health System, Singapore</aff><aff id="A90"><label>90</label>Cancer Science Institute of Singapore, National University of Singapore, Singapore</aff><aff id="A91"><label>91</label>Saw Swee Hock School of Public Health, National University of Singapore, Singapore</aff><aff id="A92"><label>92</label>Department of Surgery, National University Health System, Singapore</aff><aff id="A93"><label>93</label>Institute of Human Genetics, Pontificia Universidad Javerianar, Bogota, Colombia</aff><aff id="A94"><label>94</label>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</aff><aff id="A95"><label>95</label>International Agency for Research on Cancer, Lyon, France</aff><aff id="A96"><label>96</label>National Cancer Institute, Bangkok, Thailand</aff><aff id="A97"><label>97</label>Roswell Park Cancer Institute, Buffalo, New York, USA</aff><aff id="A98"><label>98</label>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA</aff><aff id="A99"><label>99</label>School of Public Health, China Medical University, Taichung, Taiwan</aff><aff id="A100"><label>100</label>Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</aff><aff id="A101"><label>101</label>Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</aff><aff id="A102"><label>102</label>Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</aff><aff id="A103"><label>103</label>Division of Breast Cancer Research, Institute of Cancer Research, London, UK</aff><aff id="A104"><label>104</label>Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Victoria, Australia</aff><aff id="A105"><label>105</label>Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California, USA</aff><aff id="A106"><label>106</label>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA</aff><aff id="A107"><label>107</label>Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA</aff><aff id="A108"><label>108</label>Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA</aff><aff id="A109"><label>109</label>Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA</aff><aff id="A110"><label>110</label>State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania</aff><aff id="A111"><label>111</label>Latvian Biomedical Research and Study Centre, Riga, Latvia</aff><aff id="A112"><label>112</label>Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA</aff><aff id="A113"><label>113</label>Department of Genetics, University of Pretoria, Pretoria, South Africa</aff><aff id="A114"><label>114</label>Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, USA</aff><aff id="A115"><label>115</label>Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</aff><aff id="A116"><label>116</label>Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</aff><aff id="A117"><label>117</label>Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain</aff><aff id="A118"><label>118</label>Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain</aff><aff id="A119"><label>119</label>Human Genotyping (CEGEN) Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</aff><aff id="A120"><label>120</label>City of Hope Clinical Cancer Genomics Community Research Network, Duarte, California, USA</aff><aff id="A121"><label>121</label>Clinical Cancer Genetics, City of Hope, Duarte, California, USA</aff><aff id="A122"><label>122</label>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy</aff><aff id="A123"><label>123</label>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale Tumori, Milan, Italy</aff><aff id="A124"><label>124</label>Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy</aff><aff id="A125"><label>125</label>Department of Molecular Medicine, University La Sapienza, Rome, Italy</aff><aff id="A126"><label>126</label>Molecular Diagnostics Laboratory, INRASTES (Institute of Nuclear and Radiological Sciences and Technology), National Centre for Scientific Research ‘Demokritos’, Aghia Paraskevi Attikis, Athens, Greece</aff><aff id="A127"><label>127</label>Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, Massachusetts, USA</aff><aff id="A128"><label>128</label>Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan</aff><aff id="A129"><label>130</label>Clinical Genetics, Guy’s and St. Thomas’ National Health Service (NHS) Foundation Trust, London, UK</aff><aff id="A130"><label>131</label>Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA</aff><aff id="A131"><label>132</label>Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian Albrechts University Kiel, Kiel, Germany</aff><aff id="A132"><label>133</label>University Düsseldorf, Dusseldorf, Germany</aff><aff id="A133"><label>134</label>Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology, Center for Molecular Medicine Cologne, University Hospital of Cologne, Cologne, Germany</aff><aff id="A134"><label>135</label>Institute of Human Genetics, Münster, Germany</aff><aff id="A135"><label>136</label>INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France</aff><aff id="A136"><label>137</label>Institut Curie, Department of Tumour Biology, Paris, France</aff><aff id="A137"><label>138</label>Université Paris Descartes, Sorbonne Paris Cité, Paris, France</aff><aff id="A138"><label>139</label>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon–Centre Léon Bérard, Lyon, France</aff><aff id="A139"><label>140</label>Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA</aff><aff id="A140"><label>141</label>Center for Medical Genetics, Ghent University, Ghent, Belgium</aff><aff id="A141"><label>142</label>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid, Spain</aff><aff id="A142"><label>143</label>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</aff><aff id="A143"><label>144</label>Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands</aff><aff id="A144"><label>145</label>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, the Netherlands</aff><aff id="A145"><label>146</label>Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands</aff><aff id="A146"><label>147</label>Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong</aff><aff id="A147"><label>148</label>Department of Surgery, University of Hong Kong, Hong Kong</aff><aff id="A148"><label>149</label>Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary</aff><aff id="A149"><label>150</label>Oncogenetics Laboratory, Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron University Hospital, Barcelona, Spain</aff><aff id="A150"><label>151</label>Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d’Investigació Biomèdica de Girona), Catalan Institute of Oncology, Girona, Spain</aff><aff id="A151"><label>152</label>Breast Cancer and Systems Biology Unit, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Barcelona, Spain</aff><aff id="A152"><label>153</label>Department of Pathology, Landspitali University Hospital and Biomedical Centre (BMC), Faculty of Medicine, University of Iceland, Reykjavik, Iceland</aff><aff id="A153"><label>154</label>Medical Genetic Division, Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Quebec, Canada</aff><aff id="A154"><label>155</label>Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Quebec, Canada</aff><aff id="A155"><label>156</label>Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV), IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Padua, Italy</aff><aff id="A156"><label>157</label>Department of Genetics, Portuguese Oncology Institute, Porto, Portugal</aff><aff id="A157"><label>158</label>Biomedical Sciences Institute (ICBAS), Porto University, Porto, Portugal</aff><aff id="A158"><label>159</label>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</aff><aff id="A159"><label>160</label>Program in Cancer Genetics, McGill University, Montreal, Quebec, Canada</aff><aff id="A160"><label>161</label>Masaryk Memorial Cancer Institute and Medical Faculty, Masaryk University, Brno, Czech Republic</aff><aff id="A161"><label>162</label>Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA</aff><aff id="A162"><label>163</label>Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</aff><aff id="A163"><label>164</label>Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA</aff><aff id="A164"><label>165</label>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Rockville, Maryland, USA</aff><aff id="A165"><label>166</label>Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Haifa, Israel</aff><aff id="A166"><label>167</label>Clalit National Israeli Cancer Control Center, Haifa, Israel</aff><aff id="A167"><label>168</label>N.N. Petrov Institute of Oncology, St. Petersburg, Russia</aff><aff id="A168"><label>169</label>Center for Medical Genetics, NorthShore University Health System, Evanston, Illinois, USA</aff><aff id="A169"><label>170</label>Division of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia</aff><aff id="A170"><label>171</label>NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, New York, USA</aff><aff id="A171"><label>172</label>Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada</aff><aff id="A172"><label>173</label>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada</aff><aff id="A173"><label>174</label>Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark</aff><aff id="A174"><label>175</label>Department of Clinical Genetics, Odense University Hospital, Odense, Denmark</aff><aff id="A175"><label>176</label>Section of Genetic Oncology, Department of Laboratory Medicine, University of Pisa and University Hospital of Pisa, Pisa, Italy</aff><aff id="A176"><label>177</label>University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia</aff><aff id="A177"><label>178</label>Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel</aff><aff id="A178"><label>179</label>Department of Oncology, Lund University, Lund, Sweden</aff><aff id="A179"><label>180</label>Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden</aff><aff id="A180"><label>181</label>Department of Clinical Genetics, Lund University Hospital, Lund, Sweden</aff><aff id="A181"><label>182</label>Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden</aff><aff id="A182"><label>183</label>Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, Illinois, USA</aff><aff id="A183"><label>184</label>Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center, University of California Los Angeles School of Medicine and School of Public Health, Los Angeles, California, USA</aff><aff id="A184"><label>185</label>Department of Medicine and Genetics, University of California, San Francisco, San Francisco, California, USA</aff><aff id="A185"><label>186</label>Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA</aff><aff id="A186"><label>187</label>University of Texas MD Anderson Cancer Center, Houston, Texas, USA</aff><aff id="A187"><label>188</label>Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</aff><aff id="A188"><label>189</label>Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia</aff><aff id="A189"><label>190</label>Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</aff><aff id="A190"><label>191</label>University of Hawaii Cancer Center, Honolulu, Hawaii, USA</aff><aff id="A191"><label>192</label>Department of Obstetrics, Gynaecology and Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada</aff><aff id="A192"><label>193</label>Centre for Genetic Origins of Health and Disease, University of Western Australia, Perth, Western Australia, Australia</aff><aff id="A193"><label>194</label>Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA</aff><aff id="A194"><label>195</label>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</aff><aff id="A195"><label>196</label>Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts, USA</aff><aff id="A196"><label>197</label>Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</aff><author-notes><corresp id="FN1">Correspondence should be addressed to A.M.D.
(<email>amd24@medschl.cam.ac.uk</email>), D.F.E.
(<email>dfe20@medschl.cam.ac.uk</email>) or S.L.E.
(<email>stacey.edwards@qimrberghofer.edu.au</email>)</corresp><fn id="FN2"><label>129</label><p>A full list of members appears in the <xref rid="SD1" ref-type="supplementary-material">Supplementary Note</xref>.</p></fn><fn id="FN3" fn-type="equal"><label>198</label><p>These authors contributed equally to this work.</p></fn><fn id="FN4"><label>199</label><p>These authors jointly supervised this work.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>22</day><month>6</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>29</day><month>2</month><year>2016</year></pub-date><pub-date pub-type="ppub"><month>4</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>10</month><year>2016</year></pub-date><volume>48</volume><issue>4</issue><fpage>374</fpage><lpage>386</lpage><pmc-comment>elocation-id from pubmed: 10.1038/ng.3521</pmc-comment>
<permissions><license license-type="permissions-link"><license-p>Reprints and permissions information is available online at <ext-link ext-link-type="uri" xlink:href="http://www.nature.com/reprints/index.html">http://www.nature.com/reprints/index.html</ext-link>.</license-p></license></permissions><abstract><p id="P1">We analyzed 3,872 common genetic variants across the
<italic>ESR1</italic> locus (encoding estrogen receptor α) in
118,816 subjects from three international consortia. We found evidence for at
least five independent causal variants, each associated with different phenotype
sets, including estrogen receptor (ER<sup>+</sup> or
ER<sup>−</sup>) and human ERBB2 (HER2<sup>+</sup> or
HER2<sup>−</sup>) tumor subtypes, mammographic density and tumor
grade. The best candidate causal variants for ER<sup>−</sup> tumors lie
in four separate enhancer elements, and their risk alleles reduce expression of
<italic>ESR1</italic>, <italic>RMND1</italic> and <italic>CCDC170</italic>,
whereas the risk alleles of the strongest candidates for the remaining
independent causal variant disrupt a silencer element and putatively increase
<italic>ESR1</italic> and <italic>RMND1</italic> expression.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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