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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution</title><author><name sortKey="Heid, Iris M" sort="Heid, Iris M" uniqKey="Heid I" first="Iris M" last="Heid">Iris M. Heid</name><affiliation><nlm:aff id="A1">Regensburg University Medical Center, Department of Epidemiology and Preventive Medicine, Regensburg, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Jackson, Anne U" sort="Jackson, Anne U" uniqKey="Jackson A" first="Anne U" last="Jackson">Anne U. Jackson</name><affiliation><nlm:aff id="A3">Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.</nlm:aff></affiliation></author><author><name sortKey="Randall, Joshua C" sort="Randall, Joshua C" uniqKey="Randall J" first="Joshua C" last="Randall">Joshua C. Randall</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Winkler, Thomas W" sort="Winkler, Thomas W" uniqKey="Winkler T" first="Thomas W" last="Winkler">Thomas W. Winkler</name><affiliation><nlm:aff id="A1">Regensburg University Medical Center, Department of Epidemiology and Preventive Medicine, Regensburg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Qi, Lu" sort="Qi, Lu" uniqKey="Qi L" first="Lu" last="Qi">Lu Qi</name><affiliation><nlm:aff id="A5">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Steinthorsdottir, Valgerdur" sort="Steinthorsdottir, Valgerdur" uniqKey="Steinthorsdottir V" first="Valgerdur" last="Steinthorsdottir">Valgerdur Steinthorsdottir</name><affiliation><nlm:aff id="A7">deCODE Genetics, Reykjavik, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name><affiliation><nlm:aff id="A7">deCODE Genetics, Reykjavik, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Zillikens, M Carola" sort="Zillikens, M Carola" uniqKey="Zillikens M" first="M Carola" last="Zillikens">M Carola Zillikens</name><affiliation><nlm:aff id="A8">Department of Internal Medicine, Erasmus Medical Center (MC), Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Speliotes, Elizabeth K" sort="Speliotes, Elizabeth K" uniqKey="Speliotes E" first="Elizabeth K" last="Speliotes">Elizabeth K. Speliotes</name><affiliation><nlm:aff id="A10">Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Workalemahu, Tsegaselassie" sort="Workalemahu, Tsegaselassie" uniqKey="Workalemahu T" first="Tsegaselassie" last="Workalemahu">Tsegaselassie Workalemahu</name><affiliation><nlm:aff id="A5">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="White, Charles C" sort="White, Charles C" uniqKey="White C" first="Charles C" last="White">Charles C. White</name><affiliation><nlm:aff id="A12">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Bouatia Naji, Nabila" sort="Bouatia Naji, Nabila" uniqKey="Bouatia Naji N" first="Nabila" last="Bouatia-Naji">Nabila Bouatia-Naji</name><affiliation><nlm:aff id="A13">Centre National de la Recherche Scientifique (CNRS), UMR8199-IBL-Institut Pasteur de Lille, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A14">University Lille Nord de France, Lille, France.</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B" last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="A15">Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><affiliation><nlm:aff id="A16">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation><nlm:aff id="A17">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Willer, Cristen J" sort="Willer, Cristen J" uniqKey="Willer C" first="Cristen J" last="Willer">Cristen J. Willer</name><affiliation><nlm:aff id="A3">Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.</nlm:aff></affiliation></author><author><name sortKey="Weedon, Michael N" sort="Weedon, Michael N" uniqKey="Weedon M" first="Michael N" last="Weedon">Michael N. Weedon</name><affiliation><nlm:aff id="A18">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK.</nlm:aff></affiliation></author><author><name sortKey="Luan, Jian N" sort="Luan, Jian N" uniqKey="Luan J" first="Jian N" last="Luan">Jian N Luan</name><affiliation><nlm:aff id="A19">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Vedantam, Sailaja" sort="Vedantam, Sailaja" uniqKey="Vedantam S" first="Sailaja" last="Vedantam">Sailaja Vedantam</name><affiliation><nlm:aff id="A10">Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Divisions of Genetics and Endocrinology and Program in Genomics, Children’s Hospital, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation><nlm:aff id="A21">Estonian Genome Center, University of Tartu, Tartu, Estonia.</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.</nlm:aff></affiliation></author><author><name sortKey="Kilpel Inen, Tuomas O" sort="Kilpel Inen, Tuomas O" uniqKey="Kilpel Inen T" first="Tuomas O" last="Kilpel Inen">Tuomas O. Kilpel Inen</name><affiliation><nlm:aff id="A19">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltán" last="Kutalik">Zoltán Kutalik</name><affiliation><nlm:aff id="A24">Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.</nlm:aff></affiliation><affiliation><nlm:aff id="A25">Swiss Institute of Bioinformatics, Lausanne, Switzerland.</nlm:aff></affiliation></author><author><name sortKey="Li, Shengxu" sort="Li, Shengxu" uniqKey="Li S" first="Shengxu" last="Li">Shengxu Li</name><affiliation><nlm:aff id="A19">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Monda, Keri L" sort="Monda, Keri L" uniqKey="Monda K" first="Keri L" last="Monda">Keri L. Monda</name><affiliation><nlm:aff id="A26">Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.</nlm:aff></affiliation></author><author><name sortKey="Dixon, Anna L" sort="Dixon, Anna L" uniqKey="Dixon A" first="Anna L" last="Dixon">Anna L. Dixon</name><affiliation><nlm:aff id="A27">Department of Pharmacy and Pharmacology, University of Bath, Bath, UK.</nlm:aff></affiliation></author><author><name sortKey="Holmes, Christopher C" sort="Holmes, Christopher C" uniqKey="Holmes C" first="Christopher C" last="Holmes">Christopher C. Holmes</name><affiliation><nlm:aff id="A28">MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A29">Department of Statistics, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Kaplan, Lee M" sort="Kaplan, Lee M" uniqKey="Kaplan L" first="Lee M" last="Kaplan">Lee M. Kaplan</name><affiliation><nlm:aff id="A11">Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Harvard Medical School, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A31">Massachusetts General Hospital (MGH) Weight Center, Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Liang, Liming" sort="Liang, Liming" uniqKey="Liang L" first="Liming" last="Liang">Liming Liang</name><affiliation><nlm:aff id="A32">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Min, Josine L" sort="Min, Josine L" uniqKey="Min J" first="Josine L" last="Min">Josine L. Min</name><affiliation><nlm:aff id="A34">Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Moffatt, Miriam F" sort="Moffatt, Miriam F" uniqKey="Moffatt M" first="Miriam F" last="Moffatt">Miriam F. Moffatt</name><affiliation><nlm:aff id="A35">National Heart and Lung Institute, Imperial College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Molony, Cliona" sort="Molony, Cliona" uniqKey="Molony C" first="Cliona" last="Molony">Cliona Molony</name><affiliation><nlm:aff id="A36">Merck Research Laboratories, Merck & Co., Inc., Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Nicholson, George" sort="Nicholson, George" uniqKey="Nicholson G" first="George" last="Nicholson">George Nicholson</name><affiliation><nlm:aff id="A29">Department of Statistics, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Schadt, Eric E" sort="Schadt, Eric E" uniqKey="Schadt E" first="Eric E" last="Schadt">Eric E. Schadt</name><affiliation><nlm:aff id="A37">Pacific Biosciences, Menlo Park, California, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Sage Bionetworks, Seattle, Washington, USA.</nlm:aff></affiliation></author><author><name sortKey="Zondervan, Krina T" sort="Zondervan, Krina T" uniqKey="Zondervan K" first="Krina T" last="Zondervan">Krina T. Zondervan</name><affiliation><nlm:aff id="A39">Genetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Feitosa, Mary F" sort="Feitosa, Mary F" uniqKey="Feitosa M" first="Mary F" last="Feitosa">Mary F. Feitosa</name><affiliation><nlm:aff id="A40">Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA.</nlm:aff></affiliation></author><author><name sortKey="Ferreira, Teresa" sort="Ferreira, Teresa" uniqKey="Ferreira T" first="Teresa" last="Ferreira">Teresa Ferreira</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Allen, Hana Lango" sort="Allen, Hana Lango" uniqKey="Allen H" first="Hana Lango" last="Allen">Hana Lango Allen</name><affiliation><nlm:aff id="A18">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK.</nlm:aff></affiliation></author><author><name sortKey="Weyant, Robert J" sort="Weyant, Robert J" uniqKey="Weyant R" first="Robert J" last="Weyant">Robert J. Weyant</name><affiliation><nlm:aff id="A3">Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.</nlm:aff></affiliation></author><author><name sortKey="Wheeler, Eleanor" sort="Wheeler, Eleanor" uniqKey="Wheeler E" first="Eleanor" last="Wheeler">Eleanor Wheeler</name><affiliation><nlm:aff id="A41">Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Wood, Andrew R" sort="Wood, Andrew R" uniqKey="Wood A" first="Andrew R" last="Wood">Andrew R. Wood</name><affiliation><nlm:aff id="A18">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK.</nlm:aff></affiliation></author><author><name sortKey="Estrada, Karol" sort="Estrada, Karol" uniqKey="Estrada K" first="Karol" last="Estrada">Karol Estrada</name><affiliation><nlm:aff id="A8">Department of Internal Medicine, Erasmus Medical Center (MC), Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A43">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Goddard, Michael E" sort="Goddard, Michael E" uniqKey="Goddard M" first="Michael E" last="Goddard">Michael E. Goddard</name><affiliation><nlm:aff id="A44">University of Melbourne, Parkville, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A45">Department of Primary Industries, Melbourne, Victoria, Australia.</nlm:aff></affiliation></author><author><name sortKey="Lettre, Guillaume" sort="Lettre, Guillaume" uniqKey="Lettre G" first="Guillaume" last="Lettre">Guillaume Lettre</name><affiliation><nlm:aff id="A46">Montreal Heart Institute, Montreal, Quebec, Canada.</nlm:aff></affiliation><affiliation><nlm:aff id="A47">Department of Medicine, Université de Montréal, Montreal, Quebec, Canada.</nlm:aff></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation><nlm:aff id="A48">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Nyholt, Dale R" sort="Nyholt, Dale R" uniqKey="Nyholt D" first="Dale R" last="Nyholt">Dale R. Nyholt</name><affiliation><nlm:aff id="A49">Neurogenetics Laboratory, Queensland Institute of Medical Research, Queensland, Australia.</nlm:aff></affiliation></author><author><name sortKey="Purcell, Shaun" sort="Purcell, Shaun" uniqKey="Purcell S" first="Shaun" last="Purcell">Shaun Purcell</name><affiliation><nlm:aff id="A50">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name><affiliation><nlm:aff id="A53">Icelandic Heart Association, Kopavogur, Iceland.</nlm:aff></affiliation><affiliation><nlm:aff id="A54">University of Iceland, Reykjavik, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Visscher, Peter M" sort="Visscher, Peter M" uniqKey="Visscher P" first="Peter M" last="Visscher">Peter M. Visscher</name><affiliation><nlm:aff id="A55">Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, Queensland, Australia.</nlm:aff></affiliation></author><author><name sortKey="Yang, Jian" sort="Yang, Jian" uniqKey="Yang J" first="Jian" last="Yang">Jian Yang</name><affiliation><nlm:aff id="A55">Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, Queensland, Australia.</nlm:aff></affiliation></author><author><name sortKey="Mccarroll, Steven A" sort="Mccarroll, Steven A" uniqKey="Mccarroll S" first="Steven A" last="Mccarroll">Steven A. Mccarroll</name><affiliation><nlm:aff id="A50">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Nemesh, James" sort="Nemesh, James" uniqKey="Nemesh J" first="James" last="Nemesh">James Nemesh</name><affiliation><nlm:aff id="A56">Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Voight, Benjamin F" sort="Voight, Benjamin F" uniqKey="Voight B" first="Benjamin F" last="Voight">Benjamin F. Voight</name><affiliation><nlm:aff id="A50">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Absher, Devin" sort="Absher, Devin" uniqKey="Absher D" first="Devin" last="Absher">Devin Absher</name><affiliation><nlm:aff id="A58">Hudson Alpha Institute for Biotechnology, Huntsville, Alabama, USA.</nlm:aff></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation><nlm:aff id="A43">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Aspelund, Thor" sort="Aspelund, Thor" uniqKey="Aspelund T" first="Thor" last="Aspelund">Thor Aspelund</name><affiliation><nlm:aff id="A53">Icelandic Heart Association, Kopavogur, Iceland.</nlm:aff></affiliation><affiliation><nlm:aff id="A54">University of Iceland, Reykjavik, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Coin, Lachlan" sort="Coin, Lachlan" uniqKey="Coin L" first="Lachlan" last="Coin">Lachlan Coin</name><affiliation><nlm:aff id="A59">Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Glazer, Nicole L" sort="Glazer, Nicole L" uniqKey="Glazer N" first="Nicole L" last="Glazer">Nicole L. Glazer</name><affiliation><nlm:aff id="A60">Department of Medicine, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation><nlm:aff id="A62">MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Heard Costa, Nancy L" sort="Heard Costa, Nancy L" uniqKey="Heard Costa N" first="Nancy L" last="Heard-Costa">Nancy L. Heard-Costa</name><affiliation><nlm:aff id="A63">Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><affiliation><nlm:aff id="A64">Department of Biological Psychology, Vrije Universiteit (VU) University Amsterdam, Amsterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><affiliation><nlm:aff id="A65">Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, Uppsala, Sweden.</nlm:aff></affiliation><affiliation><nlm:aff id="A66">Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.</nlm:aff></affiliation></author><author><name sortKey="Johnson, Toby" sort="Johnson, Toby" uniqKey="Johnson T" first="Toby" last="Johnson">Toby Johnson</name><affiliation><nlm:aff id="A24">Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.</nlm:aff></affiliation><affiliation><nlm:aff id="A25">Swiss Institute of Bioinformatics, Lausanne, Switzerland.</nlm:aff></affiliation><affiliation><nlm:aff id="A67">Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A68">Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London UK.</nlm:aff></affiliation></author><author><name sortKey="Kaakinen, Marika" sort="Kaakinen, Marika" uniqKey="Kaakinen M" first="Marika" last="Kaakinen">Marika Kaakinen</name><affiliation><nlm:aff id="A69">Institute of Health Sciences, University of Oulu, Oulu, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A70">Biocenter Oulu, University of Oulu, Oulu, Finland.</nlm:aff></affiliation></author><author><name sortKey="Kapur, Karen" sort="Kapur, Karen" uniqKey="Kapur K" first="Karen" last="Kapur">Karen Kapur</name><affiliation><nlm:aff id="A24">Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.</nlm:aff></affiliation><affiliation><nlm:aff id="A25">Swiss Institute of Bioinformatics, Lausanne, Switzerland.</nlm:aff></affiliation></author><author><name sortKey="Ketkar, Shamika" sort="Ketkar, Shamika" uniqKey="Ketkar S" first="Shamika" last="Ketkar">Shamika Ketkar</name><affiliation><nlm:aff id="A40">Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA.</nlm:aff></affiliation></author><author><name sortKey="Knowles, Joshua W" sort="Knowles, Joshua W" uniqKey="Knowles J" first="Joshua W" last="Knowles">Joshua W. Knowles</name><affiliation><nlm:aff id="A71">Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</nlm:aff></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="A32">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Kraja, Aldi T" sort="Kraja, Aldi T" uniqKey="Kraja A" first="Aldi T" last="Kraja">Aldi T. Kraja</name><affiliation><nlm:aff id="A40">Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA.</nlm:aff></affiliation></author><author><name sortKey="Lamina, Claudia" sort="Lamina, Claudia" uniqKey="Lamina C" first="Claudia" last="Lamina">Claudia Lamina</name><affiliation><nlm:aff id="A2">Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria.</nlm:aff></affiliation></author><author><name sortKey="Leitzmann, Michael F" sort="Leitzmann, Michael F" uniqKey="Leitzmann M" first="Michael F" last="Leitzmann">Michael F. Leitzmann</name><affiliation><nlm:aff id="A1">Regensburg University Medical Center, Department of Epidemiology and Preventive Medicine, Regensburg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Mcknight, Barbara" sort="Mcknight, Barbara" uniqKey="Mcknight B" first="Barbara" last="Mcknight">Barbara Mcknight</name><affiliation><nlm:aff id="A73">Department of Biostatistics, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation></author><author><name sortKey="Morris, Andrew P" sort="Morris, Andrew P" uniqKey="Morris A" first="Andrew P" last="Morris">Andrew P. Morris</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Ong, Ken K" sort="Ong, Ken K" uniqKey="Ong K" first="Ken K" last="Ong">Ken K. Ong</name><affiliation><nlm:aff id="A19">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Perry, John R B" sort="Perry, John R B" uniqKey="Perry J" first="John R B" last="Perry">John R B. Perry</name><affiliation><nlm:aff id="A18">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK.</nlm:aff></affiliation></author><author><name sortKey="Peters, Marjolein J" sort="Peters, Marjolein J" uniqKey="Peters M" first="Marjolein J" last="Peters">Marjolein J. Peters</name><affiliation><nlm:aff id="A8">Department of Internal Medicine, Erasmus Medical Center (MC), Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation><nlm:aff id="A74">Andrija Stampar School of Public Health, Medical School, University of Zagreb, Zagreb, Croatia.</nlm:aff></affiliation><affiliation><nlm:aff id="A75">Gen-Info Ltd, Zagreb, Croatia.</nlm:aff></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A76">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Rayner, Nigel W" sort="Rayner, Nigel W" uniqKey="Rayner N" first="Nigel W" last="Rayner">Nigel W. Rayner</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A76">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Ripatti, Samuli" sort="Ripatti, Samuli" uniqKey="Ripatti S" first="Samuli" last="Ripatti">Samuli Ripatti</name><affiliation><nlm:aff id="A77">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A78">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:aff id="A8">Department of Internal Medicine, Erasmus Medical Center (MC), Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A43">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Robertson, Neil R" sort="Robertson, Neil R" uniqKey="Robertson N" first="Neil R" last="Robertson">Neil R. Robertson</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A76">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name><affiliation><nlm:aff id="A79">Istituto di Neurogenetica e Neurofarmacologia del CNR, Monserrato, Cagliari, Italy.</nlm:aff></affiliation></author><author><name sortKey="Sovio, Ulla" sort="Sovio, Ulla" uniqKey="Sovio U" first="Ulla" last="Sovio">Ulla Sovio</name><affiliation><nlm:aff id="A59">Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Surakka, Ida" sort="Surakka, Ida" uniqKey="Surakka I" first="Ida" last="Surakka">Ida Surakka</name><affiliation><nlm:aff id="A77">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A78">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation><nlm:aff id="A80">Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.</nlm:aff></affiliation></author><author><name sortKey="Van Wingerden, Sophie" sort="Van Wingerden, Sophie" uniqKey="Van Wingerden S" first="Sophie" last="Van Wingerden">Sophie Van Wingerden</name><affiliation><nlm:aff id="A43">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation><nlm:aff id="A62">MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:aff id="A19">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Cavalcanti Proenca, Christine" sort="Cavalcanti Proenca, Christine" uniqKey="Cavalcanti Proenca C" first="Christine" last="Cavalcanti-Proença">Christine Cavalcanti-Proença</name><affiliation><nlm:aff id="A13">Centre National de la Recherche Scientifique (CNRS), UMR8199-IBL-Institut Pasteur de Lille, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A14">University Lille Nord de France, Lille, France.</nlm:aff></affiliation></author><author><name sortKey="Chines, Peter S" sort="Chines, Peter S" uniqKey="Chines P" first="Peter S" last="Chines">Peter S. Chines</name><affiliation><nlm:aff id="A81">National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Fisher, Eva" sort="Fisher, Eva" uniqKey="Fisher E" first="Eva" last="Fisher">Eva Fisher</name><affiliation><nlm:aff id="A82">Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.</nlm:aff></affiliation></author><author><name sortKey="Kulzer, Jennifer R" sort="Kulzer, Jennifer R" uniqKey="Kulzer J" first="Jennifer R" last="Kulzer">Jennifer R. Kulzer</name><affiliation><nlm:aff id="A83">Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.</nlm:aff></affiliation></author><author><name sortKey="Lecoeur, Cecile" sort="Lecoeur, Cecile" uniqKey="Lecoeur C" first="Cecile" last="Lecoeur">Cecile Lecoeur</name><affiliation><nlm:aff id="A13">Centre National de la Recherche Scientifique (CNRS), UMR8199-IBL-Institut Pasteur de Lille, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A14">University Lille Nord de France, Lille, France.</nlm:aff></affiliation></author><author><name sortKey="Narisu, Narisu" sort="Narisu, Narisu" uniqKey="Narisu N" first="Narisu" last="Narisu">Narisu Narisu</name><affiliation><nlm:aff id="A81">National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Sandholt, Camilla" sort="Sandholt, Camilla" uniqKey="Sandholt C" first="Camilla" last="Sandholt">Camilla Sandholt</name><affiliation><nlm:aff id="A84">Hagedorn Research Institute, Gentofte, Denmark.</nlm:aff></affiliation></author><author><name sortKey="Scott, Laura J" sort="Scott, Laura J" uniqKey="Scott L" first="Laura J" last="Scott">Laura J. Scott</name><affiliation><nlm:aff id="A3">Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.</nlm:aff></affiliation></author><author><name sortKey="Silander, Kaisa" sort="Silander, Kaisa" uniqKey="Silander K" first="Kaisa" last="Silander">Kaisa Silander</name><affiliation><nlm:aff id="A77">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A78">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Stark, Klaus" sort="Stark, Klaus" uniqKey="Stark K" first="Klaus" last="Stark">Klaus Stark</name><affiliation><nlm:aff id="A85">Regensburg University Medical Center, Clinic and Policlinic for Internal Medicine II, Regensburg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Tammesoo, Mari Liis" sort="Tammesoo, Mari Liis" uniqKey="Tammesoo M" first="Mari-Liis" last="Tammesoo">Mari-Liis Tammesoo</name><affiliation><nlm:aff id="A21">Estonian Genome Center, University of Tartu, Tartu, Estonia.</nlm:aff></affiliation></author><author><name sortKey="Teslovich, Tanya M" sort="Teslovich, Tanya M" uniqKey="Teslovich T" first="Tanya M" last="Teslovich">Tanya M. Teslovich</name><affiliation><nlm:aff id="A3">Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.</nlm:aff></affiliation></author><author><name sortKey="Timpson, Nicholas John" sort="Timpson, Nicholas John" uniqKey="Timpson N" first="Nicholas John" last="Timpson">Nicholas John Timpson</name><affiliation><nlm:aff id="A86">MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, Oakfield House, Bristol, UK.</nlm:aff></affiliation></author><author><name sortKey="Watanabe, Richard M" sort="Watanabe, Richard M" uniqKey="Watanabe R" first="Richard M" last="Watanabe">Richard M. Watanabe</name><affiliation><nlm:aff id="A87">Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A88">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.</nlm:aff></affiliation></author><author><name sortKey="Welch, Ryan" sort="Welch, Ryan" uniqKey="Welch R" first="Ryan" last="Welch">Ryan Welch</name><affiliation><nlm:aff id="A3">Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.</nlm:aff></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I" last="Chasman">Daniel I. Chasman</name><affiliation><nlm:aff id="A30">Harvard Medical School, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A89">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Cooper, Matthew N" sort="Cooper, Matthew N" uniqKey="Cooper M" first="Matthew N" last="Cooper">Matthew N. Cooper</name><affiliation><nlm:aff id="A90">Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Crawley, Western Australia, Australia.</nlm:aff></affiliation></author><author><name sortKey="Jansson, John Olov" sort="Jansson, John Olov" uniqKey="Jansson J" first="John-Olov" last="Jansson">John-Olov Jansson</name><affiliation><nlm:aff id="A91">Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Kettunen, Johannes" sort="Kettunen, Johannes" uniqKey="Kettunen J" first="Johannes" last="Kettunen">Johannes Kettunen</name><affiliation><nlm:aff id="A77">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A78">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Lawrence, Robert W" sort="Lawrence, Robert W" uniqKey="Lawrence R" first="Robert W" last="Lawrence">Robert W. Lawrence</name><affiliation><nlm:aff id="A90">Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Crawley, Western Australia, Australia.</nlm:aff></affiliation></author><author><name sortKey="Pellikka, Niina" sort="Pellikka, Niina" uniqKey="Pellikka N" first="Niina" last="Pellikka">Niina Pellikka</name><affiliation><nlm:aff id="A77">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A78">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Perola, Markus" sort="Perola, Markus" uniqKey="Perola M" first="Markus" last="Perola">Markus Perola</name><affiliation><nlm:aff id="A77">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A78">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Vandenput, Liesbeth" sort="Vandenput, Liesbeth" uniqKey="Vandenput L" first="Liesbeth" last="Vandenput">Liesbeth Vandenput</name><affiliation><nlm:aff id="A92">Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Alavere, Helene" sort="Alavere, Helene" uniqKey="Alavere H" first="Helene" last="Alavere">Helene Alavere</name><affiliation><nlm:aff id="A21">Estonian Genome Center, University of Tartu, Tartu, Estonia.</nlm:aff></affiliation></author><author><name sortKey="Almgren, Peter" sort="Almgren, Peter" uniqKey="Almgren P" first="Peter" last="Almgren">Peter Almgren</name><affiliation><nlm:aff id="A93">Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Malmö, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Atwood, Larry D" sort="Atwood, Larry D" uniqKey="Atwood L" first="Larry D" last="Atwood">Larry D. Atwood</name><affiliation><nlm:aff id="A63">Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Bennett, Amanda J" sort="Bennett, Amanda J" uniqKey="Bennett A" first="Amanda J" last="Bennett">Amanda J. Bennett</name><affiliation><nlm:aff id="A76">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Biffar, Reiner" sort="Biffar, Reiner" uniqKey="Biffar R" first="Reiner" last="Biffar">Reiner Biffar</name><affiliation><nlm:aff id="A94">Zentrum für Zahn-, Mund- und Kieferheilkunde, Greifswald, Germany.</nlm:aff></affiliation></author><author><name sortKey="Bonnycastle, Lori L" sort="Bonnycastle, Lori L" uniqKey="Bonnycastle L" first="Lori L" last="Bonnycastle">Lori L. Bonnycastle</name><affiliation><nlm:aff id="A81">National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Bornstein, Stefan R" sort="Bornstein, Stefan R" uniqKey="Bornstein S" first="Stefan R" last="Bornstein">Stefan R. Bornstein</name><affiliation><nlm:aff id="A95">Department of Medicine III, University of Dresden, Dresden, Germany.</nlm:aff></affiliation></author><author><name sortKey="Buchanan, Thomas A" sort="Buchanan, Thomas A" uniqKey="Buchanan T" first="Thomas A" last="Buchanan">Thomas A. Buchanan</name><affiliation><nlm:aff id="A87">Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A96">Division of Endocrinology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.</nlm:aff></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation><nlm:aff id="A97">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Day, Ian N M" sort="Day, Ian N M" uniqKey="Day I" first="Ian N M" last="Day">Ian N M. Day</name><affiliation><nlm:aff id="A86">MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, Oakfield House, Bristol, UK.</nlm:aff></affiliation></author><author><name sortKey="Dei, Mariano" sort="Dei, Mariano" uniqKey="Dei M" first="Mariano" last="Dei">Mariano Dei</name><affiliation><nlm:aff id="A79">Istituto di Neurogenetica e Neurofarmacologia del CNR, Monserrato, Cagliari, Italy.</nlm:aff></affiliation></author><author><name sortKey="Dorr, Marcus" sort="Dorr, Marcus" uniqKey="Dorr M" first="Marcus" last="Dörr">Marcus Dörr</name><affiliation><nlm:aff id="A98">Department of Internal Medicine B, Ernst-Moritz-Arndt University, Greifswald, Germany.</nlm:aff></affiliation></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation><nlm:aff id="A59">Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A99">MRC-Health Protection Agency (HPA) Centre for Environment and Health, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Erdos, Michael R" sort="Erdos, Michael R" uniqKey="Erdos M" first="Michael R" last="Erdos">Michael R. Erdos</name><affiliation><nlm:aff id="A81">National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G" last="Eriksson">Johan G. Eriksson</name><affiliation><nlm:aff id="A100">Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A104">Vasa Central Hospital, Vasa, Finland.</nlm:aff></affiliation></author><author><name sortKey="Freimer, Nelson B" sort="Freimer, Nelson B" uniqKey="Freimer N" first="Nelson B" last="Freimer">Nelson B. Freimer</name><affiliation><nlm:aff id="A105">Center for Neurobehavioral Genetics, University of California, Los Angeles, California, USA.</nlm:aff></affiliation></author><author><name sortKey="Fu, Mao" sort="Fu, Mao" uniqKey="Fu M" first="Mao" last="Fu">Mao Fu</name><affiliation><nlm:aff id="A106">Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Gaget, Stefan" sort="Gaget, Stefan" uniqKey="Gaget S" first="Stefan" last="Gaget">Stefan Gaget</name><affiliation><nlm:aff id="A13">Centre National de la Recherche Scientifique (CNRS), UMR8199-IBL-Institut Pasteur de Lille, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A14">University Lille Nord de France, Lille, France.</nlm:aff></affiliation></author><author><name sortKey="Geus, Eco J C" sort="Geus, Eco J C" uniqKey="Geus E" first="Eco J C" last="Geus">Eco J C. Geus</name><affiliation><nlm:aff id="A64">Department of Biological Psychology, Vrije Universiteit (VU) University Amsterdam, Amsterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Gjesing, Anette P" sort="Gjesing, Anette P" uniqKey="Gjesing A" first="Anette P" last="Gjesing">Anette P. Gjesing</name><affiliation><nlm:aff id="A84">Hagedorn Research Institute, Gentofte, Denmark.</nlm:aff></affiliation></author><author><name sortKey="Grallert, Harald" sort="Grallert, Harald" uniqKey="Grallert H" first="Harald" last="Grallert">Harald Grallert</name><affiliation><nlm:aff id="A2">Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Gr Ler, Jurgen" sort="Gr Ler, Jurgen" uniqKey="Gr Ler J" first="Jürgen" last="Gr Ler">Jürgen Gr Ler</name><affiliation><nlm:aff id="A107">Department of Medicine III, Pathobiochemistry, University of Dresden, Dresden, Germany.</nlm:aff></affiliation></author><author><name sortKey="Groves, Christopher J" sort="Groves, Christopher J" uniqKey="Groves C" first="Christopher J" last="Groves">Christopher J. Groves</name><affiliation><nlm:aff id="A76">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Guiducci, Candace" sort="Guiducci, Candace" uniqKey="Guiducci C" first="Candace" last="Guiducci">Candace Guiducci</name><affiliation><nlm:aff id="A10">Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation><nlm:aff id="A108">Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, Oulu, Finland.</nlm:aff></affiliation></author><author><name sortKey="Hassanali, Neelam" sort="Hassanali, Neelam" uniqKey="Hassanali N" first="Neelam" last="Hassanali">Neelam Hassanali</name><affiliation><nlm:aff id="A76">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Havulinna, Aki S" sort="Havulinna, Aki S" uniqKey="Havulinna A" first="Aki S" last="Havulinna">Aki S. Havulinna</name><affiliation><nlm:aff id="A109">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Chronic Disease Epidemiology and Prevention Unit, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Herzig, Karl Heinz" sort="Herzig, Karl Heinz" uniqKey="Herzig K" first="Karl-Heinz" last="Herzig">Karl-Heinz Herzig</name><affiliation><nlm:aff id="A70">Biocenter Oulu, University of Oulu, Oulu, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A110">Institute of Biomedicine, Department of Physiology, University of Oulu, Oulu, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A111">Department of Psychiatry, Kuopio University Hospital and University of Kuopio, Kuopio, Finland.</nlm:aff></affiliation></author><author><name sortKey="Hicks, Andrew A" sort="Hicks, Andrew A" uniqKey="Hicks A" first="Andrew A" last="Hicks">Andrew A. Hicks</name><affiliation><nlm:aff id="A112">Institute of Genetic Medicine, European Academy Bozen-Bolzano (EURAC), Bolzano-Bozen, Italy (affiliated Institute of the University of Lübeck, Lübeck, Germany).</nlm:aff></affiliation></author><author><name sortKey="Hui, Jennie" sort="Hui, Jennie" uniqKey="Hui J" first="Jennie" last="Hui">Jennie Hui</name><affiliation><nlm:aff id="A90">Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Crawley, Western Australia, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A113">PathWest Laboratory of Western Australia, Department of Molecular Genetics, J Block, QEII Medical Centre, Nedlands, Western Australia, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A114">Busselton Population Medical Research Foundation Inc., Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.</nlm:aff></affiliation></author><author><name sortKey="Igl, Wilmar" sort="Igl, Wilmar" uniqKey="Igl W" first="Wilmar" last="Igl">Wilmar Igl</name><affiliation><nlm:aff id="A65">Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, Uppsala, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Jousilahti, Pekka" sort="Jousilahti, Pekka" uniqKey="Jousilahti P" first="Pekka" last="Jousilahti">Pekka Jousilahti</name><affiliation><nlm:aff id="A109">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Chronic Disease Epidemiology and Prevention Unit, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Jula, Antti" sort="Jula, Antti" uniqKey="Jula A" first="Antti" last="Jula">Antti Jula</name><affiliation><nlm:aff id="A115">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Population Studies Unit, Turku, Finland.</nlm:aff></affiliation></author><author><name sortKey="Kajantie, Eero" sort="Kajantie, Eero" uniqKey="Kajantie E" first="Eero" last="Kajantie">Eero Kajantie</name><affiliation><nlm:aff id="A101">National Institute for Health and Welfare, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A116">Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Kinnunen, Leena" sort="Kinnunen, Leena" uniqKey="Kinnunen L" first="Leena" last="Kinnunen">Leena Kinnunen</name><affiliation><nlm:aff id="A117">National Institute for Health and Welfare, Diabetes Prevention Unit, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Kolcic, Ivana" sort="Kolcic, Ivana" uniqKey="Kolcic I" first="Ivana" last="Kolcic">Ivana Kolcic</name><affiliation><nlm:aff id="A74">Andrija Stampar School of Public Health, Medical School, University of Zagreb, Zagreb, Croatia.</nlm:aff></affiliation></author><author><name sortKey="Koskinen, Seppo" sort="Koskinen, Seppo" uniqKey="Koskinen S" first="Seppo" last="Koskinen">Seppo Koskinen</name><affiliation><nlm:aff id="A109">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Chronic Disease Epidemiology and Prevention Unit, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Kovacs, Peter" sort="Kovacs, Peter" uniqKey="Kovacs P" first="Peter" last="Kovacs">Peter Kovacs</name><affiliation><nlm:aff id="A118">Interdisciplinary Centre for Clinical Research, University of Leipzig, Leipzig, Germany.</nlm:aff></affiliation></author><author><name sortKey="Kroemer, Heyo K" sort="Kroemer, Heyo K" uniqKey="Kroemer H" first="Heyo K" last="Kroemer">Heyo K. Kroemer</name><affiliation><nlm:aff id="A119">Institut für Pharmakologie, Universität Greifswald, Greifswald, Germany.</nlm:aff></affiliation></author><author><name sortKey="Krzelj, Vjekoslav" sort="Krzelj, Vjekoslav" uniqKey="Krzelj V" first="Vjekoslav" last="Krzelj">Vjekoslav Krzelj</name><affiliation><nlm:aff id="A120">Croatian Centre for Global Health, School of Medicine, University of Split, Split, Croatia.</nlm:aff></affiliation></author><author><name sortKey="Kuusisto, Johanna" sort="Kuusisto, Johanna" uniqKey="Kuusisto J" first="Johanna" last="Kuusisto">Johanna Kuusisto</name><affiliation><nlm:aff id="A121">Department of Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland.</nlm:aff></affiliation></author><author><name sortKey="Kvaloy, Kirsti" sort="Kvaloy, Kirsti" uniqKey="Kvaloy K" first="Kirsti" last="Kvaloy">Kirsti Kvaloy</name><affiliation><nlm:aff id="A122">Nord-Trøndelag Health Study (HUNT) Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.</nlm:aff></affiliation></author><author><name sortKey="Laitinen, Jaana" sort="Laitinen, Jaana" uniqKey="Laitinen J" first="Jaana" last="Laitinen">Jaana Laitinen</name><affiliation><nlm:aff id="A123">Finnish Institute of Occupational Health, Oulu, Finland.</nlm:aff></affiliation></author><author><name sortKey="Lantieri, Olivier" sort="Lantieri, Olivier" uniqKey="Lantieri O" first="Olivier" last="Lantieri">Olivier Lantieri</name><affiliation><nlm:aff id="A124">Institut inter-regional pour la sante (IRSA), La Riche, France.</nlm:aff></affiliation></author><author><name sortKey="Lathrop, G Mark" sort="Lathrop, G Mark" uniqKey="Lathrop G" first="G Mark" last="Lathrop">G Mark Lathrop</name><affiliation><nlm:aff id="A125">Centre National de Genotypage, Evry, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Lokki, Marja Liisa" sort="Lokki, Marja Liisa" uniqKey="Lokki M" first="Marja-Liisa" last="Lokki">Marja-Liisa Lokki</name><affiliation><nlm:aff id="A126">Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Luben, Robert N" sort="Luben, Robert N" uniqKey="Luben R" first="Robert N" last="Luben">Robert N. Luben</name><affiliation><nlm:aff id="A127">Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Ludwig, Barbara" sort="Ludwig, Barbara" uniqKey="Ludwig B" first="Barbara" last="Ludwig">Barbara Ludwig</name><affiliation><nlm:aff id="A95">Department of Medicine III, University of Dresden, Dresden, Germany.</nlm:aff></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L" last="Mcardle">Wendy L. Mcardle</name><affiliation><nlm:aff id="A128">Avon Longitudinal Study of Parents and Children (ALSPAC) Laboratory, Department of Social Medicine, University of Bristol, Bristol, UK.</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Anne" sort="Mccarthy, Anne" uniqKey="Mccarthy A" first="Anne" last="Mccarthy">Anne Mccarthy</name><affiliation><nlm:aff id="A129">Division of Health, Research Board, An Bord Taighde Sláinte, Dublin, Ireland.</nlm:aff></affiliation></author><author><name sortKey="Morken, Mario A" sort="Morken, Mario A" uniqKey="Morken M" first="Mario A" last="Morken">Mario A. Morken</name><affiliation><nlm:aff id="A81">National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Nelis, Mari" sort="Nelis, Mari" uniqKey="Nelis M" first="Mari" last="Nelis">Mari Nelis</name><affiliation><nlm:aff id="A21">Estonian Genome Center, University of Tartu, Tartu, Estonia.</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.</nlm:aff></affiliation></author><author><name sortKey="Neville, Matt J" sort="Neville, Matt J" uniqKey="Neville M" first="Matt J" last="Neville">Matt J. Neville</name><affiliation><nlm:aff id="A76">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Pare, Guillaume" sort="Pare, Guillaume" uniqKey="Pare G" first="Guillaume" last="Paré">Guillaume Paré</name><affiliation><nlm:aff id="A130">Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.</nlm:aff></affiliation></author><author><name sortKey="Parker, Alex N" sort="Parker, Alex N" uniqKey="Parker A" first="Alex N" last="Parker">Alex N. Parker</name><affiliation><nlm:aff id="A131">Amgen, Cambridge, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Peden, John F" sort="Peden, John F" uniqKey="Peden J" first="John F" last="Peden">John F. Peden</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A132">Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Pichler, Irene" sort="Pichler, Irene" uniqKey="Pichler I" first="Irene" last="Pichler">Irene Pichler</name><affiliation><nlm:aff id="A112">Institute of Genetic Medicine, European Academy Bozen-Bolzano (EURAC), Bolzano-Bozen, Italy (affiliated Institute of the University of Lübeck, Lübeck, Germany).</nlm:aff></affiliation></author><author><name sortKey="Pietil Inen, Kirsi H" sort="Pietil Inen, Kirsi H" uniqKey="Pietil Inen K" first="Kirsi H" last="Pietil Inen">Kirsi H. Pietil Inen</name><affiliation><nlm:aff id="A133">Finnish Twin Cohort Study, Department of Public Health, University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A134">Obesity Research Unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Platou, Carl G P" sort="Platou, Carl G P" uniqKey="Platou C" first="Carl G P" last="Platou">Carl G P. Platou</name><affiliation><nlm:aff id="A122">Nord-Trøndelag Health Study (HUNT) Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.</nlm:aff></affiliation><affiliation><nlm:aff id="A135">Department of Medicine, Levanger Hospital, The Nord-Trøndelag Health Trust, Levanger, Norway.</nlm:aff></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><affiliation><nlm:aff id="A108">Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, Oulu, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A136">National Institute for Health and Welfare, Oulu, Finland.</nlm:aff></affiliation></author><author><name sortKey="Ridderstr Le, Martin" sort="Ridderstr Le, Martin" uniqKey="Ridderstr Le M" first="Martin" last="Ridderstr Le">Martin Ridderstr Le</name><affiliation><nlm:aff id="A137">Department of Clinical Sciences, Lund University, Malmö, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J" last="Samani">Nilesh J. Samani</name><affiliation><nlm:aff id="A138">Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A139">Leicester National Institute for Health Research (NIHR) Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, UK.</nlm:aff></affiliation></author><author><name sortKey="Saramies, Jouko" sort="Saramies, Jouko" uniqKey="Saramies J" first="Jouko" last="Saramies">Jouko Saramies</name><affiliation><nlm:aff id="A140">South Karelia Central Hospital, Lappeenranta, Finland.</nlm:aff></affiliation></author><author><name sortKey="Sinisalo, Juha" sort="Sinisalo, Juha" uniqKey="Sinisalo J" first="Juha" last="Sinisalo">Juha Sinisalo</name><affiliation><nlm:aff id="A141">Division of Cardiology, Cardiovascular Laboratory, Helsinki University Central Hospital, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Smit, Jan H" sort="Smit, Jan H" uniqKey="Smit J" first="Jan H" last="Smit">Jan H. Smit</name><affiliation><nlm:aff id="A142">Department of Psychiatry/Instituut voor Extramuraal Geneeskundig Onderzoek (EMGO) Institute, VU University Medical Center, Amsterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Strawbridge, Rona J" sort="Strawbridge, Rona J" uniqKey="Strawbridge R" first="Rona J" last="Strawbridge">Rona J. Strawbridge</name><affiliation><nlm:aff id="A143">Atherosclerosis Research Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Stringham, Heather M" sort="Stringham, Heather M" uniqKey="Stringham H" first="Heather M" last="Stringham">Heather M. Stringham</name><affiliation><nlm:aff id="A3">Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.</nlm:aff></affiliation></author><author><name sortKey="Swift, Amy J" sort="Swift, Amy J" uniqKey="Swift A" first="Amy J" last="Swift">Amy J. Swift</name><affiliation><nlm:aff id="A81">National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Teder Laving, Maris" sort="Teder Laving, Maris" uniqKey="Teder Laving M" first="Maris" last="Teder-Laving">Maris Teder-Laving</name><affiliation><nlm:aff id="A22">Estonian Biocenter, Tartu, Estonia.</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.</nlm:aff></affiliation></author><author><name sortKey="Thomson, Brian" sort="Thomson, Brian" uniqKey="Thomson B" first="Brian" last="Thomson">Brian Thomson</name><affiliation><nlm:aff id="A10">Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Usala, Gianluca" sort="Usala, Gianluca" uniqKey="Usala G" first="Gianluca" last="Usala">Gianluca Usala</name><affiliation><nlm:aff id="A79">Istituto di Neurogenetica e Neurofarmacologia del CNR, Monserrato, Cagliari, Italy.</nlm:aff></affiliation></author><author><name sortKey="Van Meurs, Joyce B J" sort="Van Meurs, Joyce B J" uniqKey="Van Meurs J" first="Joyce B J" last="Van Meurs">Joyce B J. Van Meurs</name><affiliation><nlm:aff id="A8">Department of Internal Medicine, Erasmus Medical Center (MC), Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A43">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Van Ommen, Gert Jan" sort="Van Ommen, Gert Jan" uniqKey="Van Ommen G" first="Gert-Jan" last="Van Ommen">Gert-Jan Van Ommen</name><affiliation><nlm:aff id="A144">Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A145">Center of Medical Systems Biology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Vatin, Vincent" sort="Vatin, Vincent" uniqKey="Vatin V" first="Vincent" last="Vatin">Vincent Vatin</name><affiliation><nlm:aff id="A13">Centre National de la Recherche Scientifique (CNRS), UMR8199-IBL-Institut Pasteur de Lille, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A14">University Lille Nord de France, Lille, France.</nlm:aff></affiliation></author><author><name sortKey="Volpato, Claudia B" sort="Volpato, Claudia B" uniqKey="Volpato C" first="Claudia B" last="Volpato">Claudia B. Volpato</name><affiliation><nlm:aff id="A112">Institute of Genetic Medicine, European Academy Bozen-Bolzano (EURAC), Bolzano-Bozen, Italy (affiliated Institute of the University of Lübeck, Lübeck, Germany).</nlm:aff></affiliation></author><author><name sortKey="Wallaschofski, Henri" sort="Wallaschofski, Henri" uniqKey="Wallaschofski H" first="Henri" last="Wallaschofski">Henri Wallaschofski</name><affiliation><nlm:aff id="A146">Institut für Klinische Chemie und Laboratoriumsmedizin, Universität Greifswald, Greifswald, Germany.</nlm:aff></affiliation></author><author><name sortKey="Walters, G Bragi" sort="Walters, G Bragi" uniqKey="Walters G" first="G Bragi" last="Walters">G Bragi Walters</name><affiliation><nlm:aff id="A7">deCODE Genetics, Reykjavik, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widen">Elisabeth Widen</name><affiliation><nlm:aff id="A77">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H" last="Wild">Sarah H. Wild</name><affiliation><nlm:aff id="A97">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation><nlm:aff id="A64">Department of Biological Psychology, Vrije Universiteit (VU) University Amsterdam, Amsterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Witte, Daniel R" sort="Witte, Daniel R" uniqKey="Witte D" first="Daniel R" last="Witte">Daniel R. Witte</name><affiliation><nlm:aff id="A147">Steno Diabetes Center, Gentofte, Denmark.</nlm:aff></affiliation></author><author><name sortKey="Zgaga, Lina" sort="Zgaga, Lina" uniqKey="Zgaga L" first="Lina" last="Zgaga">Lina Zgaga</name><affiliation><nlm:aff id="A74">Andrija Stampar School of Public Health, Medical School, University of Zagreb, Zagreb, Croatia.</nlm:aff></affiliation></author><author><name sortKey="Zitting, Paavo" sort="Zitting, Paavo" uniqKey="Zitting P" first="Paavo" last="Zitting">Paavo Zitting</name><affiliation><nlm:aff id="A148">Department of Physiatrics, Lapland Central Hospital, Rovaniemi, Finland.</nlm:aff></affiliation></author><author><name sortKey="Beilby, John P" sort="Beilby, John P" uniqKey="Beilby J" first="John P" last="Beilby">John P. Beilby</name><affiliation><nlm:aff id="A113">PathWest Laboratory of Western Australia, Department of Molecular Genetics, J Block, QEII Medical Centre, Nedlands, Western Australia, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A114">Busselton Population Medical Research Foundation Inc., Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A149">School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Western Australia, Australia.</nlm:aff></affiliation></author><author><name sortKey="James, Alan L" sort="James, Alan L" uniqKey="James A" first="Alan L" last="James">Alan L. James</name><affiliation><nlm:aff id="A114">Busselton Population Medical Research Foundation Inc., Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A150">School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia.</nlm:aff></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation><nlm:aff id="A151">Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland.</nlm:aff></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation><nlm:aff id="A152">Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Tampere, Finland.</nlm:aff></affiliation></author><author><name sortKey="Nieminen, Markku S" sort="Nieminen, Markku S" uniqKey="Nieminen M" first="Markku S" last="Nieminen">Markku S. Nieminen</name><affiliation><nlm:aff id="A141">Division of Cardiology, Cardiovascular Laboratory, Helsinki University Central Hospital, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Ohlsson, Claes" sort="Ohlsson, Claes" uniqKey="Ohlsson C" first="Claes" last="Ohlsson">Claes Ohlsson</name><affiliation><nlm:aff id="A92">Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J" last="Palmer">Lyle J. Palmer</name><affiliation><nlm:aff id="A90">Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Crawley, Western Australia, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A114">Busselton Population Medical Research Foundation Inc., Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.</nlm:aff></affiliation></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><affiliation><nlm:aff id="A153">Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A154">The Department of Clinical Physiology, Turku University Hospital, Turku, Finland.</nlm:aff></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name><affiliation><nlm:aff id="A30">Harvard Medical School, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A89">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name><affiliation><nlm:aff id="A155">Department of Medicine, University of Leipzig, Leipzig, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A156">Leipziger Interdisziplinärer Forschungskomplex zu molekularen Ursachen umwelt- und lebensstilassoziierter Erkrankungen (LIFE) Study Centre, University of Leipzig, Leipzig, Germany.</nlm:aff></affiliation></author><author><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tönjes">Anke Tönjes</name><affiliation><nlm:aff id="A155">Department of Medicine, University of Leipzig, Leipzig, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A157">Coordination Centre for Clinical Trials, University of Leipzig, Leipzig, Germany.</nlm:aff></affiliation></author><author><name sortKey="Viikari, Jorma" sort="Viikari, Jorma" uniqKey="Viikari J" first="Jorma" last="Viikari">Jorma Viikari</name><affiliation><nlm:aff id="A158">Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland.</nlm:aff></affiliation></author><author><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name><affiliation><nlm:aff id="A159">INSERM Centre de Recherche en Epidémiologie et Santé des Populations (CESP) U1018, Villejuif, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A160">University Paris Sud 11, Unité Mixte de Recherche en Santé (UMRS) 1018, Villejuif, France.</nlm:aff></affiliation></author><author><name sortKey="Ben Shlomo, Yoav" sort="Ben Shlomo, Yoav" uniqKey="Ben Shlomo Y" first="Yoav" last="Ben-Shlomo">Yoav Ben-Shlomo</name><affiliation><nlm:aff id="A161">Department of Social Medicine, University of Bristol, Bristol, UK.</nlm:aff></affiliation></author><author><name sortKey="Bergman, Richard N" sort="Bergman, Richard N" uniqKey="Bergman R" first="Richard N" last="Bergman">Richard N. Bergman</name><affiliation><nlm:aff id="A87">Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.</nlm:aff></affiliation></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><affiliation><nlm:aff id="A82">Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.</nlm:aff></affiliation></author><author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name><affiliation><nlm:aff id="A86">MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, Oakfield House, Bristol, UK.</nlm:aff></affiliation></author><author><name sortKey="Ebrahim, Shah" sort="Ebrahim, Shah" uniqKey="Ebrahim S" first="Shah" last="Ebrahim">Shah Ebrahim</name><affiliation><nlm:aff id="A162">The London School of Hygiene and Tropical Medicine, London, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A163">South Asia Network for Chronic Disease, New Delhi, India.</nlm:aff></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation><nlm:aff id="A13">Centre National de la Recherche Scientifique (CNRS), UMR8199-IBL-Institut Pasteur de Lille, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A14">University Lille Nord de France, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A164">Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Hansen, Torben" sort="Hansen, Torben" uniqKey="Hansen T" first="Torben" last="Hansen">Torben Hansen</name><affiliation><nlm:aff id="A84">Hagedorn Research Institute, Gentofte, Denmark.</nlm:aff></affiliation><affiliation><nlm:aff id="A165">Faculty of Health Science, University of Southern Denmark, Odense, Denmark.</nlm:aff></affiliation></author><author><name sortKey="Hengstenberg, Christian" sort="Hengstenberg, Christian" uniqKey="Hengstenberg C" first="Christian" last="Hengstenberg">Christian Hengstenberg</name><affiliation><nlm:aff id="A166">Klinik und Poliklinik für Innere Medizin II, Universität Regensburg, Regensburg, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A167">Regensburg University Medical Center, Innere Medizin II, Regensburg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Hveem, Kristian" sort="Hveem, Kristian" uniqKey="Hveem K" first="Kristian" last="Hveem">Kristian Hveem</name><affiliation><nlm:aff id="A122">Nord-Trøndelag Health Study (HUNT) Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.</nlm:aff></affiliation></author><author><name sortKey="Isomaa, Bo" sort="Isomaa, Bo" uniqKey="Isomaa B" first="Bo" last="Isomaa">Bo Isomaa</name><affiliation><nlm:aff id="A103">Folkhalsan Research Centre, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A168">Department of Social Services and Health Care, Jakobstad, Finland.</nlm:aff></affiliation></author><author><name sortKey="J Rgensen, Torben" sort="J Rgensen, Torben" uniqKey="J Rgensen T" first="Torben" last="J Rgensen">Torben J Rgensen</name><affiliation><nlm:aff id="A169">Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark.</nlm:aff></affiliation><affiliation><nlm:aff id="A170">Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.</nlm:aff></affiliation></author><author><name sortKey="Karpe, Fredrik" sort="Karpe, Fredrik" uniqKey="Karpe F" first="Fredrik" last="Karpe">Fredrik Karpe</name><affiliation><nlm:aff id="A76">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A171">NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation><nlm:aff id="A127">Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Laakso, Markku" sort="Laakso, Markku" uniqKey="Laakso M" first="Markku" last="Laakso">Markku Laakso</name><affiliation><nlm:aff id="A121">Department of Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland.</nlm:aff></affiliation></author><author><name sortKey="Lawlor, Debbie A" sort="Lawlor, Debbie A" uniqKey="Lawlor D" first="Debbie A" last="Lawlor">Debbie A. Lawlor</name><affiliation><nlm:aff id="A86">MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, Oakfield House, Bristol, UK.</nlm:aff></affiliation></author><author><name sortKey="Marre, Michel" sort="Marre, Michel" uniqKey="Marre M" first="Michel" last="Marre">Michel Marre</name><affiliation><nlm:aff id="A172">Department of Endocrinology, Diabetology and Nutrition, Bichat-Claude Bernard University Hospital, Assistance Publique des Hôpitaux de Paris, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A173">Cardiovascular Genetics Research Unit, Université Henri Poincaré-Nancy 1, Nancy, France.</nlm:aff></affiliation></author><author><name sortKey="Meitinger, Thomas" sort="Meitinger, Thomas" uniqKey="Meitinger T" first="Thomas" last="Meitinger">Thomas Meitinger</name><affiliation><nlm:aff id="A174">Institute of Human Genetics, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A175">Institute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation><nlm:aff id="A21">Estonian Genome Center, University of Tartu, Tartu, Estonia.</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.</nlm:aff></affiliation></author><author><name sortKey="Midthjell, Kristian" sort="Midthjell, Kristian" uniqKey="Midthjell K" first="Kristian" last="Midthjell">Kristian Midthjell</name><affiliation><nlm:aff id="A122">Nord-Trøndelag Health Study (HUNT) Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.</nlm:aff></affiliation></author><author><name sortKey="Pedersen, Oluf" sort="Pedersen, Oluf" uniqKey="Pedersen O" first="Oluf" last="Pedersen">Oluf Pedersen</name><affiliation><nlm:aff id="A84">Hagedorn Research Institute, Gentofte, Denmark.</nlm:aff></affiliation><affiliation><nlm:aff id="A176">Institute of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:aff></affiliation><affiliation><nlm:aff id="A177">Faculty of Health Science, University of Aarhus, Aarhus, Denmark.</nlm:aff></affiliation></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name><affiliation><nlm:aff id="A109">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Chronic Disease Epidemiology and Prevention Unit, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Schwarz, Peter E H" sort="Schwarz, Peter E H" uniqKey="Schwarz P" first="Peter E H" last="Schwarz">Peter E H. Schwarz</name><affiliation><nlm:aff id="A178">Department of Medicine III, Prevention and Care of Diabetes, University of Dresden, Dresden, Germany.</nlm:aff></affiliation></author><author><name sortKey="Tuomi, Tiinamaija" sort="Tuomi, Tiinamaija" uniqKey="Tuomi T" first="Tiinamaija" last="Tuomi">Tiinamaija Tuomi</name><affiliation><nlm:aff id="A103">Folkhalsan Research Centre, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A179">Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A180">Research Program of Molecular Medicine, University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Tuomilehto, Jaakko" sort="Tuomilehto, Jaakko" uniqKey="Tuomilehto J" first="Jaakko" last="Tuomilehto">Jaakko Tuomilehto</name><affiliation><nlm:aff id="A117">National Institute for Health and Welfare, Diabetes Prevention Unit, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A181">Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A182">South Ostrobothnia Central Hospital, Seinajoki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Valle, Timo T" sort="Valle, Timo T" uniqKey="Valle T" first="Timo T" last="Valle">Timo T. Valle</name><affiliation><nlm:aff id="A117">National Institute for Health and Welfare, Diabetes Prevention Unit, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="A19">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Arnold, Alice M" sort="Arnold, Alice M" uniqKey="Arnold A" first="Alice M" last="Arnold">Alice M. Arnold</name><affiliation><nlm:aff id="A73">Department of Biostatistics, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A183">Collaborative Health Studies Coordinating Center, Seattle, Washington, USA.</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Jacques S" sort="Beckmann, Jacques S" uniqKey="Beckmann J" first="Jacques S" last="Beckmann">Jacques S. Beckmann</name><affiliation><nlm:aff id="A24">Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.</nlm:aff></affiliation><affiliation><nlm:aff id="A184">Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, Lausanne, Switzerland.</nlm:aff></affiliation></author><author><name sortKey="Bergmann, Sven" sort="Bergmann, Sven" uniqKey="Bergmann S" first="Sven" last="Bergmann">Sven Bergmann</name><affiliation><nlm:aff id="A24">Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.</nlm:aff></affiliation><affiliation><nlm:aff id="A25">Swiss Institute of Bioinformatics, Lausanne, Switzerland.</nlm:aff></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation><nlm:aff id="A185">Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas, USA.</nlm:aff></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I" last="Boomsma">Dorret I. Boomsma</name><affiliation><nlm:aff id="A64">Department of Biological Psychology, Vrije Universiteit (VU) University Amsterdam, Amsterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Caulfield, Mark J" sort="Caulfield, Mark J" uniqKey="Caulfield M" first="Mark J" last="Caulfield">Mark J. Caulfield</name><affiliation><nlm:aff id="A68">Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London UK.</nlm:aff></affiliation></author><author><name sortKey="Collins, Francis S" sort="Collins, Francis S" uniqKey="Collins F" first="Francis S" last="Collins">Francis S. Collins</name><affiliation><nlm:aff id="A81">National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation><nlm:aff id="A53">Icelandic Heart Association, Kopavogur, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:aff id="A53">Icelandic Heart Association, Kopavogur, Iceland.</nlm:aff></affiliation><affiliation><nlm:aff id="A54">University of Iceland, Reykjavik, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation><nlm:aff id="A65">Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, Uppsala, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Hamsten, Anders" sort="Hamsten, Anders" uniqKey="Hamsten A" first="Anders" last="Hamsten">Anders Hamsten</name><affiliation><nlm:aff id="A143">Atherosclerosis Research Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Hattersley, Andrew T" sort="Hattersley, Andrew T" uniqKey="Hattersley A" first="Andrew T" last="Hattersley">Andrew T. Hattersley</name><affiliation><nlm:aff id="A18">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK.</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="A9">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A43">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Hu, Frank B" sort="Hu, Frank B" uniqKey="Hu F" first="Frank B" last="Hu">Frank B. Hu</name><affiliation><nlm:aff id="A5">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A32">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><affiliation><nlm:aff id="A2">Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Iribarren, Carlos" sort="Iribarren, Carlos" uniqKey="Iribarren C" first="Carlos" last="Iribarren">Carlos Iribarren</name><affiliation><nlm:aff id="A186">Division of Research, Kaiser Permanente Northern California, Oakland, California, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A187">Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.</nlm:aff></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation><nlm:aff id="A59">Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A69">Institute of Health Sciences, University of Oulu, Oulu, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A70">Biocenter Oulu, University of Oulu, Oulu, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A136">National Institute for Health and Welfare, Oulu, Finland.</nlm:aff></affiliation></author><author><name sortKey="Kao, W H Linda" sort="Kao, W H Linda" uniqKey="Kao W" first="W H Linda" last="Kao">W H Linda Kao</name><affiliation><nlm:aff id="A188">Department of Epidemiology and Medicine, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><affiliation><nlm:aff id="A77">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A133">Finnish Twin Cohort Study, Department of Public Health, University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A189">National Institute for Health and Welfare, Department of Mental Health and Substance Abuse Services, Unit for Child and Adolescent Mental Health, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name><affiliation><nlm:aff id="A15">Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Munroe, Patricia B" sort="Munroe, Patricia B" uniqKey="Munroe P" first="Patricia B" last="Munroe">Patricia B. Munroe</name><affiliation><nlm:aff id="A68">Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London UK.</nlm:aff></affiliation></author><author><name sortKey="Oostra, Ben" sort="Oostra, Ben" uniqKey="Oostra B" first="Ben" last="Oostra">Ben Oostra</name><affiliation><nlm:aff id="A190">Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W" last="Penninx">Brenda W. Penninx</name><affiliation><nlm:aff id="A142">Department of Psychiatry/Instituut voor Extramuraal Geneeskundig Onderzoek (EMGO) Institute, VU University Medical Center, Amsterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A191">Department of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A192">Department of Psychiatry, University Medical Centre Groningen, Groningen, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P" last="Pramstaller">Peter P. Pramstaller</name><affiliation><nlm:aff id="A112">Institute of Genetic Medicine, European Academy Bozen-Bolzano (EURAC), Bolzano-Bozen, Italy (affiliated Institute of the University of Lübeck, Lübeck, Germany).</nlm:aff></affiliation><affiliation><nlm:aff id="A193">Department of Neurology, General Central Hospital, Bolzano, Italy.</nlm:aff></affiliation><affiliation><nlm:aff id="A194">Department of Neurology, University of Lübeck, Lübeck, Germany.</nlm:aff></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M" last="Psaty">Bruce M. Psaty</name><affiliation><nlm:aff id="A195">Departments of Epidemiology, Medicine and Health Services, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A196">Group Health Research Institute, Group Health, Seattle, Washington, USA.</nlm:aff></affiliation></author><author><name sortKey="Quertermous, Thomas" sort="Quertermous, Thomas" uniqKey="Quertermous T" first="Thomas" last="Quertermous">Thomas Quertermous</name><affiliation><nlm:aff id="A71">Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</nlm:aff></affiliation></author><author><name sortKey="Rissanen, Aila" sort="Rissanen, Aila" uniqKey="Rissanen A" first="Aila" last="Rissanen">Aila Rissanen</name><affiliation><nlm:aff id="A134">Obesity Research Unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation><nlm:aff id="A97">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A120">Croatian Centre for Global Health, School of Medicine, University of Split, Split, Croatia.</nlm:aff></affiliation></author><author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R" last="Shuldiner">Alan R. Shuldiner</name><affiliation><nlm:aff id="A106">Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A197">Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation><nlm:aff id="A41">Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D" last="Spector">Timothy D. Spector</name><affiliation><nlm:aff id="A48">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Syvanen, Ann Christine" sort="Syvanen, Ann Christine" uniqKey="Syvanen A" first="Ann-Christine" last="Syvanen">Ann-Christine Syvanen</name><affiliation><nlm:aff id="A198">Uppsala University, Department of Medical Sciences, Molecular Medicine, Uppsala, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Uda, Manuela" sort="Uda, Manuela" uniqKey="Uda M" first="Manuela" last="Uda">Manuela Uda</name><affiliation><nlm:aff id="A79">Istituto di Neurogenetica e Neurofarmacologia del CNR, Monserrato, Cagliari, Italy.</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre" sort="Uitterlinden, Andre" uniqKey="Uitterlinden A" first="André" last="Uitterlinden">André Uitterlinden</name><affiliation><nlm:aff id="A8">Department of Internal Medicine, Erasmus Medical Center (MC), Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A43">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation><nlm:aff id="A199">Institut für Community Medicine, Greifswald, Germany.</nlm:aff></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation><nlm:aff id="A200">Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, Lausanne, Switzerland.</nlm:aff></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F" last="Wilson">James F. Wilson</name><affiliation><nlm:aff id="A97">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Witteman, Jacqueline C" sort="Witteman, Jacqueline C" uniqKey="Witteman J" first="Jacqueline C" last="Witteman">Jacqueline C. Witteman</name><affiliation><nlm:aff id="A9">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A43">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F" last="Wright">Alan F. Wright</name><affiliation><nlm:aff id="A62">MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Abecasis, Goncalo R" sort="Abecasis, Goncalo R" uniqKey="Abecasis G" first="Gonçalo R" last="Abecasis">Gonçalo R. Abecasis</name><affiliation><nlm:aff id="A3">Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.</nlm:aff></affiliation></author><author><name sortKey="Boehnke, Michael" sort="Boehnke, Michael" uniqKey="Boehnke M" first="Michael" last="Boehnke">Michael Boehnke</name><affiliation><nlm:aff id="A3">Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.</nlm:aff></affiliation></author><author><name sortKey="Borecki, Ingrid B" sort="Borecki, Ingrid B" uniqKey="Borecki I" first="Ingrid B" last="Borecki">Ingrid B. Borecki</name><affiliation><nlm:aff id="A40">Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A201">Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA.</nlm:aff></affiliation></author><author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name><affiliation><nlm:aff id="A41">Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Frayling, Timothy M" sort="Frayling, Timothy M" uniqKey="Frayling T" first="Timothy M" last="Frayling">Timothy M. Frayling</name><affiliation><nlm:aff id="A18">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK.</nlm:aff></affiliation></author><author><name sortKey="Groop, Leif C" sort="Groop, Leif C" uniqKey="Groop L" first="Leif C" last="Groop">Leif C. Groop</name><affiliation><nlm:aff id="A93">Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Malmö, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Haritunians, Talin" sort="Haritunians, Talin" uniqKey="Haritunians T" first="Talin" last="Haritunians">Talin Haritunians</name><affiliation><nlm:aff id="A202">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.</nlm:aff></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name><affiliation><nlm:aff id="A5">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A32">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Kaplan, Robert C" sort="Kaplan, Robert C" uniqKey="Kaplan R" first="Robert C" last="Kaplan">Robert C. Kaplan</name><affiliation><nlm:aff id="A203">Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.</nlm:aff></affiliation></author><author><name sortKey="North, Kari E" sort="North, Kari E" uniqKey="North K" first="Kari E" last="North">Kari E. North</name><affiliation><nlm:aff id="A26">Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A204">Carolina Center for Genome Sciences, School of Public Health, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA.</nlm:aff></affiliation></author><author><name sortKey="O Onnell, Jeffrey R" sort="O Onnell, Jeffrey R" uniqKey="O Onnell J" first="Jeffrey R" last="O Onnell">Jeffrey R. O Onnell</name><affiliation><nlm:aff id="A106">Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Peltonen, Leena" sort="Peltonen, Leena" uniqKey="Peltonen L" first="Leena" last="Peltonen">Leena Peltonen</name><affiliation><nlm:aff id="A41">Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A51">The Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A77">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A101">National Institute for Health and Welfare, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A205">Department of Medical Genetics, University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Schlessinger, David" sort="Schlessinger, David" uniqKey="Schlessinger D" first="David" last="Schlessinger">David Schlessinger</name><affiliation><nlm:aff id="A206">Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P" last="Strachan">David P. Strachan</name><affiliation><nlm:aff id="A207">Division of Community Health Sciences, St George’s, University of London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N" last="Hirschhorn">Joel N. Hirschhorn</name><affiliation><nlm:aff id="A10">Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Divisions of Genetics and Endocrinology and Program in Genomics, Children’s Hospital, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A208">Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Assimes, Themistocles L" sort="Assimes, Themistocles L" uniqKey="Assimes T" first="Themistocles L" last="Assimes">Themistocles L. Assimes</name><affiliation><nlm:aff id="A71">Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</nlm:aff></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H-Erich" last="Wichmann">H-Erich Wichmann</name><affiliation><nlm:aff id="A2">Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A209">Klinikum Grosshadern, Munich, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A210">Ludwig-Maximilians-Universität, Institute of Medical Informatics, Biometry and Epidemiology, Munich, Germany.</nlm:aff></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation><nlm:aff id="A7">deCODE Genetics, Reykjavik, Iceland.</nlm:aff></affiliation><affiliation><nlm:aff id="A211">Faculty of Medicine, University of Iceland, Reykjavík, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:aff id="A9">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A43">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation><nlm:aff id="A7">deCODE Genetics, Reykjavik, Iceland.</nlm:aff></affiliation><affiliation><nlm:aff id="A211">Faculty of Medicine, University of Iceland, Reykjavík, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Cupples, L Adrienne" sort="Cupples, L Adrienne" uniqKey="Cupples L" first="L Adrienne" last="Cupples">L Adrienne Cupples</name><affiliation><nlm:aff id="A12">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J F" last="Loos">Ruth J F. Loos</name><affiliation><nlm:aff id="A19">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Barroso, Ines" sort="Barroso, Ines" uniqKey="Barroso I" first="Inês" last="Barroso">Inês Barroso</name><affiliation><nlm:aff id="A41">Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A212">University of Cambridge Metabolic Research Labs, Institute of Metabolic Science Addenbrooke’s Hospital, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I" last="Mccarthy">Mark I. Mccarthy</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A76">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A171">NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S" last="Fox">Caroline S. Fox</name><affiliation><nlm:aff id="A213">Division of Intramural Research, National Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Mohlke, Karen L" sort="Mohlke, Karen L" uniqKey="Mohlke K" first="Karen L" last="Mohlke">Karen L. Mohlke</name><affiliation><nlm:aff id="A83">Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.</nlm:aff></affiliation></author><author><name sortKey="Lindgren, Cecilia M" sort="Lindgren, Cecilia M" uniqKey="Lindgren C" first="Cecilia M" last="Lindgren">Cecilia M. Lindgren</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A76">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20935629</idno><idno type="pmc">3000924</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000924</idno><idno type="RBID">PMC:3000924</idno><idno type="doi">10.1038/ng.685</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">002127</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002127</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution</title><author><name sortKey="Heid, Iris M" sort="Heid, Iris M" uniqKey="Heid I" first="Iris M" last="Heid">Iris M. Heid</name><affiliation><nlm:aff id="A1">Regensburg University Medical Center, Department of Epidemiology and Preventive Medicine, Regensburg, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Jackson, Anne U" sort="Jackson, Anne U" uniqKey="Jackson A" first="Anne U" last="Jackson">Anne U. Jackson</name><affiliation><nlm:aff id="A3">Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.</nlm:aff></affiliation></author><author><name sortKey="Randall, Joshua C" sort="Randall, Joshua C" uniqKey="Randall J" first="Joshua C" last="Randall">Joshua C. Randall</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Winkler, Thomas W" sort="Winkler, Thomas W" uniqKey="Winkler T" first="Thomas W" last="Winkler">Thomas W. Winkler</name><affiliation><nlm:aff id="A1">Regensburg University Medical Center, Department of Epidemiology and Preventive Medicine, Regensburg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Qi, Lu" sort="Qi, Lu" uniqKey="Qi L" first="Lu" last="Qi">Lu Qi</name><affiliation><nlm:aff id="A5">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Steinthorsdottir, Valgerdur" sort="Steinthorsdottir, Valgerdur" uniqKey="Steinthorsdottir V" first="Valgerdur" last="Steinthorsdottir">Valgerdur Steinthorsdottir</name><affiliation><nlm:aff id="A7">deCODE Genetics, Reykjavik, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name><affiliation><nlm:aff id="A7">deCODE Genetics, Reykjavik, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Zillikens, M Carola" sort="Zillikens, M Carola" uniqKey="Zillikens M" first="M Carola" last="Zillikens">M Carola Zillikens</name><affiliation><nlm:aff id="A8">Department of Internal Medicine, Erasmus Medical Center (MC), Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Speliotes, Elizabeth K" sort="Speliotes, Elizabeth K" uniqKey="Speliotes E" first="Elizabeth K" last="Speliotes">Elizabeth K. Speliotes</name><affiliation><nlm:aff id="A10">Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Workalemahu, Tsegaselassie" sort="Workalemahu, Tsegaselassie" uniqKey="Workalemahu T" first="Tsegaselassie" last="Workalemahu">Tsegaselassie Workalemahu</name><affiliation><nlm:aff id="A5">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="White, Charles C" sort="White, Charles C" uniqKey="White C" first="Charles C" last="White">Charles C. White</name><affiliation><nlm:aff id="A12">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Bouatia Naji, Nabila" sort="Bouatia Naji, Nabila" uniqKey="Bouatia Naji N" first="Nabila" last="Bouatia-Naji">Nabila Bouatia-Naji</name><affiliation><nlm:aff id="A13">Centre National de la Recherche Scientifique (CNRS), UMR8199-IBL-Institut Pasteur de Lille, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A14">University Lille Nord de France, Lille, France.</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B" last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="A15">Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><affiliation><nlm:aff id="A16">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation><nlm:aff id="A17">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Willer, Cristen J" sort="Willer, Cristen J" uniqKey="Willer C" first="Cristen J" last="Willer">Cristen J. Willer</name><affiliation><nlm:aff id="A3">Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.</nlm:aff></affiliation></author><author><name sortKey="Weedon, Michael N" sort="Weedon, Michael N" uniqKey="Weedon M" first="Michael N" last="Weedon">Michael N. Weedon</name><affiliation><nlm:aff id="A18">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK.</nlm:aff></affiliation></author><author><name sortKey="Luan, Jian N" sort="Luan, Jian N" uniqKey="Luan J" first="Jian N" last="Luan">Jian N Luan</name><affiliation><nlm:aff id="A19">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Vedantam, Sailaja" sort="Vedantam, Sailaja" uniqKey="Vedantam S" first="Sailaja" last="Vedantam">Sailaja Vedantam</name><affiliation><nlm:aff id="A10">Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Divisions of Genetics and Endocrinology and Program in Genomics, Children’s Hospital, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation><nlm:aff id="A21">Estonian Genome Center, University of Tartu, Tartu, Estonia.</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.</nlm:aff></affiliation></author><author><name sortKey="Kilpel Inen, Tuomas O" sort="Kilpel Inen, Tuomas O" uniqKey="Kilpel Inen T" first="Tuomas O" last="Kilpel Inen">Tuomas O. Kilpel Inen</name><affiliation><nlm:aff id="A19">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltán" last="Kutalik">Zoltán Kutalik</name><affiliation><nlm:aff id="A24">Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.</nlm:aff></affiliation><affiliation><nlm:aff id="A25">Swiss Institute of Bioinformatics, Lausanne, Switzerland.</nlm:aff></affiliation></author><author><name sortKey="Li, Shengxu" sort="Li, Shengxu" uniqKey="Li S" first="Shengxu" last="Li">Shengxu Li</name><affiliation><nlm:aff id="A19">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Monda, Keri L" sort="Monda, Keri L" uniqKey="Monda K" first="Keri L" last="Monda">Keri L. Monda</name><affiliation><nlm:aff id="A26">Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.</nlm:aff></affiliation></author><author><name sortKey="Dixon, Anna L" sort="Dixon, Anna L" uniqKey="Dixon A" first="Anna L" last="Dixon">Anna L. Dixon</name><affiliation><nlm:aff id="A27">Department of Pharmacy and Pharmacology, University of Bath, Bath, UK.</nlm:aff></affiliation></author><author><name sortKey="Holmes, Christopher C" sort="Holmes, Christopher C" uniqKey="Holmes C" first="Christopher C" last="Holmes">Christopher C. Holmes</name><affiliation><nlm:aff id="A28">MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A29">Department of Statistics, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Kaplan, Lee M" sort="Kaplan, Lee M" uniqKey="Kaplan L" first="Lee M" last="Kaplan">Lee M. Kaplan</name><affiliation><nlm:aff id="A11">Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Harvard Medical School, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A31">Massachusetts General Hospital (MGH) Weight Center, Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Liang, Liming" sort="Liang, Liming" uniqKey="Liang L" first="Liming" last="Liang">Liming Liang</name><affiliation><nlm:aff id="A32">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Min, Josine L" sort="Min, Josine L" uniqKey="Min J" first="Josine L" last="Min">Josine L. Min</name><affiliation><nlm:aff id="A34">Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Moffatt, Miriam F" sort="Moffatt, Miriam F" uniqKey="Moffatt M" first="Miriam F" last="Moffatt">Miriam F. Moffatt</name><affiliation><nlm:aff id="A35">National Heart and Lung Institute, Imperial College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Molony, Cliona" sort="Molony, Cliona" uniqKey="Molony C" first="Cliona" last="Molony">Cliona Molony</name><affiliation><nlm:aff id="A36">Merck Research Laboratories, Merck & Co., Inc., Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Nicholson, George" sort="Nicholson, George" uniqKey="Nicholson G" first="George" last="Nicholson">George Nicholson</name><affiliation><nlm:aff id="A29">Department of Statistics, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Schadt, Eric E" sort="Schadt, Eric E" uniqKey="Schadt E" first="Eric E" last="Schadt">Eric E. Schadt</name><affiliation><nlm:aff id="A37">Pacific Biosciences, Menlo Park, California, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Sage Bionetworks, Seattle, Washington, USA.</nlm:aff></affiliation></author><author><name sortKey="Zondervan, Krina T" sort="Zondervan, Krina T" uniqKey="Zondervan K" first="Krina T" last="Zondervan">Krina T. Zondervan</name><affiliation><nlm:aff id="A39">Genetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Feitosa, Mary F" sort="Feitosa, Mary F" uniqKey="Feitosa M" first="Mary F" last="Feitosa">Mary F. Feitosa</name><affiliation><nlm:aff id="A40">Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA.</nlm:aff></affiliation></author><author><name sortKey="Ferreira, Teresa" sort="Ferreira, Teresa" uniqKey="Ferreira T" first="Teresa" last="Ferreira">Teresa Ferreira</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Allen, Hana Lango" sort="Allen, Hana Lango" uniqKey="Allen H" first="Hana Lango" last="Allen">Hana Lango Allen</name><affiliation><nlm:aff id="A18">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK.</nlm:aff></affiliation></author><author><name sortKey="Weyant, Robert J" sort="Weyant, Robert J" uniqKey="Weyant R" first="Robert J" last="Weyant">Robert J. Weyant</name><affiliation><nlm:aff id="A3">Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.</nlm:aff></affiliation></author><author><name sortKey="Wheeler, Eleanor" sort="Wheeler, Eleanor" uniqKey="Wheeler E" first="Eleanor" last="Wheeler">Eleanor Wheeler</name><affiliation><nlm:aff id="A41">Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Wood, Andrew R" sort="Wood, Andrew R" uniqKey="Wood A" first="Andrew R" last="Wood">Andrew R. Wood</name><affiliation><nlm:aff id="A18">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK.</nlm:aff></affiliation></author><author><name sortKey="Estrada, Karol" sort="Estrada, Karol" uniqKey="Estrada K" first="Karol" last="Estrada">Karol Estrada</name><affiliation><nlm:aff id="A8">Department of Internal Medicine, Erasmus Medical Center (MC), Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A43">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Goddard, Michael E" sort="Goddard, Michael E" uniqKey="Goddard M" first="Michael E" last="Goddard">Michael E. Goddard</name><affiliation><nlm:aff id="A44">University of Melbourne, Parkville, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A45">Department of Primary Industries, Melbourne, Victoria, Australia.</nlm:aff></affiliation></author><author><name sortKey="Lettre, Guillaume" sort="Lettre, Guillaume" uniqKey="Lettre G" first="Guillaume" last="Lettre">Guillaume Lettre</name><affiliation><nlm:aff id="A46">Montreal Heart Institute, Montreal, Quebec, Canada.</nlm:aff></affiliation><affiliation><nlm:aff id="A47">Department of Medicine, Université de Montréal, Montreal, Quebec, Canada.</nlm:aff></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation><nlm:aff id="A48">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Nyholt, Dale R" sort="Nyholt, Dale R" uniqKey="Nyholt D" first="Dale R" last="Nyholt">Dale R. Nyholt</name><affiliation><nlm:aff id="A49">Neurogenetics Laboratory, Queensland Institute of Medical Research, Queensland, Australia.</nlm:aff></affiliation></author><author><name sortKey="Purcell, Shaun" sort="Purcell, Shaun" uniqKey="Purcell S" first="Shaun" last="Purcell">Shaun Purcell</name><affiliation><nlm:aff id="A50">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name><affiliation><nlm:aff id="A53">Icelandic Heart Association, Kopavogur, Iceland.</nlm:aff></affiliation><affiliation><nlm:aff id="A54">University of Iceland, Reykjavik, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Visscher, Peter M" sort="Visscher, Peter M" uniqKey="Visscher P" first="Peter M" last="Visscher">Peter M. Visscher</name><affiliation><nlm:aff id="A55">Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, Queensland, Australia.</nlm:aff></affiliation></author><author><name sortKey="Yang, Jian" sort="Yang, Jian" uniqKey="Yang J" first="Jian" last="Yang">Jian Yang</name><affiliation><nlm:aff id="A55">Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, Queensland, Australia.</nlm:aff></affiliation></author><author><name sortKey="Mccarroll, Steven A" sort="Mccarroll, Steven A" uniqKey="Mccarroll S" first="Steven A" last="Mccarroll">Steven A. Mccarroll</name><affiliation><nlm:aff id="A50">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Nemesh, James" sort="Nemesh, James" uniqKey="Nemesh J" first="James" last="Nemesh">James Nemesh</name><affiliation><nlm:aff id="A56">Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Voight, Benjamin F" sort="Voight, Benjamin F" uniqKey="Voight B" first="Benjamin F" last="Voight">Benjamin F. Voight</name><affiliation><nlm:aff id="A50">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Absher, Devin" sort="Absher, Devin" uniqKey="Absher D" first="Devin" last="Absher">Devin Absher</name><affiliation><nlm:aff id="A58">Hudson Alpha Institute for Biotechnology, Huntsville, Alabama, USA.</nlm:aff></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation><nlm:aff id="A43">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Aspelund, Thor" sort="Aspelund, Thor" uniqKey="Aspelund T" first="Thor" last="Aspelund">Thor Aspelund</name><affiliation><nlm:aff id="A53">Icelandic Heart Association, Kopavogur, Iceland.</nlm:aff></affiliation><affiliation><nlm:aff id="A54">University of Iceland, Reykjavik, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Coin, Lachlan" sort="Coin, Lachlan" uniqKey="Coin L" first="Lachlan" last="Coin">Lachlan Coin</name><affiliation><nlm:aff id="A59">Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Glazer, Nicole L" sort="Glazer, Nicole L" uniqKey="Glazer N" first="Nicole L" last="Glazer">Nicole L. Glazer</name><affiliation><nlm:aff id="A60">Department of Medicine, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation><nlm:aff id="A62">MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Heard Costa, Nancy L" sort="Heard Costa, Nancy L" uniqKey="Heard Costa N" first="Nancy L" last="Heard-Costa">Nancy L. Heard-Costa</name><affiliation><nlm:aff id="A63">Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><affiliation><nlm:aff id="A64">Department of Biological Psychology, Vrije Universiteit (VU) University Amsterdam, Amsterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><affiliation><nlm:aff id="A65">Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, Uppsala, Sweden.</nlm:aff></affiliation><affiliation><nlm:aff id="A66">Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.</nlm:aff></affiliation></author><author><name sortKey="Johnson, Toby" sort="Johnson, Toby" uniqKey="Johnson T" first="Toby" last="Johnson">Toby Johnson</name><affiliation><nlm:aff id="A24">Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.</nlm:aff></affiliation><affiliation><nlm:aff id="A25">Swiss Institute of Bioinformatics, Lausanne, Switzerland.</nlm:aff></affiliation><affiliation><nlm:aff id="A67">Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A68">Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London UK.</nlm:aff></affiliation></author><author><name sortKey="Kaakinen, Marika" sort="Kaakinen, Marika" uniqKey="Kaakinen M" first="Marika" last="Kaakinen">Marika Kaakinen</name><affiliation><nlm:aff id="A69">Institute of Health Sciences, University of Oulu, Oulu, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A70">Biocenter Oulu, University of Oulu, Oulu, Finland.</nlm:aff></affiliation></author><author><name sortKey="Kapur, Karen" sort="Kapur, Karen" uniqKey="Kapur K" first="Karen" last="Kapur">Karen Kapur</name><affiliation><nlm:aff id="A24">Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.</nlm:aff></affiliation><affiliation><nlm:aff id="A25">Swiss Institute of Bioinformatics, Lausanne, Switzerland.</nlm:aff></affiliation></author><author><name sortKey="Ketkar, Shamika" sort="Ketkar, Shamika" uniqKey="Ketkar S" first="Shamika" last="Ketkar">Shamika Ketkar</name><affiliation><nlm:aff id="A40">Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA.</nlm:aff></affiliation></author><author><name sortKey="Knowles, Joshua W" sort="Knowles, Joshua W" uniqKey="Knowles J" first="Joshua W" last="Knowles">Joshua W. Knowles</name><affiliation><nlm:aff id="A71">Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</nlm:aff></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="A32">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Kraja, Aldi T" sort="Kraja, Aldi T" uniqKey="Kraja A" first="Aldi T" last="Kraja">Aldi T. Kraja</name><affiliation><nlm:aff id="A40">Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA.</nlm:aff></affiliation></author><author><name sortKey="Lamina, Claudia" sort="Lamina, Claudia" uniqKey="Lamina C" first="Claudia" last="Lamina">Claudia Lamina</name><affiliation><nlm:aff id="A2">Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria.</nlm:aff></affiliation></author><author><name sortKey="Leitzmann, Michael F" sort="Leitzmann, Michael F" uniqKey="Leitzmann M" first="Michael F" last="Leitzmann">Michael F. Leitzmann</name><affiliation><nlm:aff id="A1">Regensburg University Medical Center, Department of Epidemiology and Preventive Medicine, Regensburg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Mcknight, Barbara" sort="Mcknight, Barbara" uniqKey="Mcknight B" first="Barbara" last="Mcknight">Barbara Mcknight</name><affiliation><nlm:aff id="A73">Department of Biostatistics, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation></author><author><name sortKey="Morris, Andrew P" sort="Morris, Andrew P" uniqKey="Morris A" first="Andrew P" last="Morris">Andrew P. Morris</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Ong, Ken K" sort="Ong, Ken K" uniqKey="Ong K" first="Ken K" last="Ong">Ken K. Ong</name><affiliation><nlm:aff id="A19">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Perry, John R B" sort="Perry, John R B" uniqKey="Perry J" first="John R B" last="Perry">John R B. Perry</name><affiliation><nlm:aff id="A18">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK.</nlm:aff></affiliation></author><author><name sortKey="Peters, Marjolein J" sort="Peters, Marjolein J" uniqKey="Peters M" first="Marjolein J" last="Peters">Marjolein J. Peters</name><affiliation><nlm:aff id="A8">Department of Internal Medicine, Erasmus Medical Center (MC), Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation><nlm:aff id="A74">Andrija Stampar School of Public Health, Medical School, University of Zagreb, Zagreb, Croatia.</nlm:aff></affiliation><affiliation><nlm:aff id="A75">Gen-Info Ltd, Zagreb, Croatia.</nlm:aff></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A76">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Rayner, Nigel W" sort="Rayner, Nigel W" uniqKey="Rayner N" first="Nigel W" last="Rayner">Nigel W. Rayner</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A76">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Ripatti, Samuli" sort="Ripatti, Samuli" uniqKey="Ripatti S" first="Samuli" last="Ripatti">Samuli Ripatti</name><affiliation><nlm:aff id="A77">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A78">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:aff id="A8">Department of Internal Medicine, Erasmus Medical Center (MC), Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A43">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Robertson, Neil R" sort="Robertson, Neil R" uniqKey="Robertson N" first="Neil R" last="Robertson">Neil R. Robertson</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A76">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name><affiliation><nlm:aff id="A79">Istituto di Neurogenetica e Neurofarmacologia del CNR, Monserrato, Cagliari, Italy.</nlm:aff></affiliation></author><author><name sortKey="Sovio, Ulla" sort="Sovio, Ulla" uniqKey="Sovio U" first="Ulla" last="Sovio">Ulla Sovio</name><affiliation><nlm:aff id="A59">Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Surakka, Ida" sort="Surakka, Ida" uniqKey="Surakka I" first="Ida" last="Surakka">Ida Surakka</name><affiliation><nlm:aff id="A77">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A78">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation><nlm:aff id="A80">Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.</nlm:aff></affiliation></author><author><name sortKey="Van Wingerden, Sophie" sort="Van Wingerden, Sophie" uniqKey="Van Wingerden S" first="Sophie" last="Van Wingerden">Sophie Van Wingerden</name><affiliation><nlm:aff id="A43">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation><nlm:aff id="A62">MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:aff id="A19">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Cavalcanti Proenca, Christine" sort="Cavalcanti Proenca, Christine" uniqKey="Cavalcanti Proenca C" first="Christine" last="Cavalcanti-Proença">Christine Cavalcanti-Proença</name><affiliation><nlm:aff id="A13">Centre National de la Recherche Scientifique (CNRS), UMR8199-IBL-Institut Pasteur de Lille, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A14">University Lille Nord de France, Lille, France.</nlm:aff></affiliation></author><author><name sortKey="Chines, Peter S" sort="Chines, Peter S" uniqKey="Chines P" first="Peter S" last="Chines">Peter S. Chines</name><affiliation><nlm:aff id="A81">National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Fisher, Eva" sort="Fisher, Eva" uniqKey="Fisher E" first="Eva" last="Fisher">Eva Fisher</name><affiliation><nlm:aff id="A82">Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.</nlm:aff></affiliation></author><author><name sortKey="Kulzer, Jennifer R" sort="Kulzer, Jennifer R" uniqKey="Kulzer J" first="Jennifer R" last="Kulzer">Jennifer R. Kulzer</name><affiliation><nlm:aff id="A83">Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.</nlm:aff></affiliation></author><author><name sortKey="Lecoeur, Cecile" sort="Lecoeur, Cecile" uniqKey="Lecoeur C" first="Cecile" last="Lecoeur">Cecile Lecoeur</name><affiliation><nlm:aff id="A13">Centre National de la Recherche Scientifique (CNRS), UMR8199-IBL-Institut Pasteur de Lille, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A14">University Lille Nord de France, Lille, France.</nlm:aff></affiliation></author><author><name sortKey="Narisu, Narisu" sort="Narisu, Narisu" uniqKey="Narisu N" first="Narisu" last="Narisu">Narisu Narisu</name><affiliation><nlm:aff id="A81">National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Sandholt, Camilla" sort="Sandholt, Camilla" uniqKey="Sandholt C" first="Camilla" last="Sandholt">Camilla Sandholt</name><affiliation><nlm:aff id="A84">Hagedorn Research Institute, Gentofte, Denmark.</nlm:aff></affiliation></author><author><name sortKey="Scott, Laura J" sort="Scott, Laura J" uniqKey="Scott L" first="Laura J" last="Scott">Laura J. Scott</name><affiliation><nlm:aff id="A3">Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.</nlm:aff></affiliation></author><author><name sortKey="Silander, Kaisa" sort="Silander, Kaisa" uniqKey="Silander K" first="Kaisa" last="Silander">Kaisa Silander</name><affiliation><nlm:aff id="A77">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A78">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Stark, Klaus" sort="Stark, Klaus" uniqKey="Stark K" first="Klaus" last="Stark">Klaus Stark</name><affiliation><nlm:aff id="A85">Regensburg University Medical Center, Clinic and Policlinic for Internal Medicine II, Regensburg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Tammesoo, Mari Liis" sort="Tammesoo, Mari Liis" uniqKey="Tammesoo M" first="Mari-Liis" last="Tammesoo">Mari-Liis Tammesoo</name><affiliation><nlm:aff id="A21">Estonian Genome Center, University of Tartu, Tartu, Estonia.</nlm:aff></affiliation></author><author><name sortKey="Teslovich, Tanya M" sort="Teslovich, Tanya M" uniqKey="Teslovich T" first="Tanya M" last="Teslovich">Tanya M. Teslovich</name><affiliation><nlm:aff id="A3">Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.</nlm:aff></affiliation></author><author><name sortKey="Timpson, Nicholas John" sort="Timpson, Nicholas John" uniqKey="Timpson N" first="Nicholas John" last="Timpson">Nicholas John Timpson</name><affiliation><nlm:aff id="A86">MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, Oakfield House, Bristol, UK.</nlm:aff></affiliation></author><author><name sortKey="Watanabe, Richard M" sort="Watanabe, Richard M" uniqKey="Watanabe R" first="Richard M" last="Watanabe">Richard M. Watanabe</name><affiliation><nlm:aff id="A87">Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A88">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.</nlm:aff></affiliation></author><author><name sortKey="Welch, Ryan" sort="Welch, Ryan" uniqKey="Welch R" first="Ryan" last="Welch">Ryan Welch</name><affiliation><nlm:aff id="A3">Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.</nlm:aff></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I" last="Chasman">Daniel I. Chasman</name><affiliation><nlm:aff id="A30">Harvard Medical School, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A89">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Cooper, Matthew N" sort="Cooper, Matthew N" uniqKey="Cooper M" first="Matthew N" last="Cooper">Matthew N. Cooper</name><affiliation><nlm:aff id="A90">Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Crawley, Western Australia, Australia.</nlm:aff></affiliation></author><author><name sortKey="Jansson, John Olov" sort="Jansson, John Olov" uniqKey="Jansson J" first="John-Olov" last="Jansson">John-Olov Jansson</name><affiliation><nlm:aff id="A91">Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Kettunen, Johannes" sort="Kettunen, Johannes" uniqKey="Kettunen J" first="Johannes" last="Kettunen">Johannes Kettunen</name><affiliation><nlm:aff id="A77">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A78">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Lawrence, Robert W" sort="Lawrence, Robert W" uniqKey="Lawrence R" first="Robert W" last="Lawrence">Robert W. Lawrence</name><affiliation><nlm:aff id="A90">Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Crawley, Western Australia, Australia.</nlm:aff></affiliation></author><author><name sortKey="Pellikka, Niina" sort="Pellikka, Niina" uniqKey="Pellikka N" first="Niina" last="Pellikka">Niina Pellikka</name><affiliation><nlm:aff id="A77">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A78">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Perola, Markus" sort="Perola, Markus" uniqKey="Perola M" first="Markus" last="Perola">Markus Perola</name><affiliation><nlm:aff id="A77">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A78">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Vandenput, Liesbeth" sort="Vandenput, Liesbeth" uniqKey="Vandenput L" first="Liesbeth" last="Vandenput">Liesbeth Vandenput</name><affiliation><nlm:aff id="A92">Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Alavere, Helene" sort="Alavere, Helene" uniqKey="Alavere H" first="Helene" last="Alavere">Helene Alavere</name><affiliation><nlm:aff id="A21">Estonian Genome Center, University of Tartu, Tartu, Estonia.</nlm:aff></affiliation></author><author><name sortKey="Almgren, Peter" sort="Almgren, Peter" uniqKey="Almgren P" first="Peter" last="Almgren">Peter Almgren</name><affiliation><nlm:aff id="A93">Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Malmö, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Atwood, Larry D" sort="Atwood, Larry D" uniqKey="Atwood L" first="Larry D" last="Atwood">Larry D. Atwood</name><affiliation><nlm:aff id="A63">Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Bennett, Amanda J" sort="Bennett, Amanda J" uniqKey="Bennett A" first="Amanda J" last="Bennett">Amanda J. Bennett</name><affiliation><nlm:aff id="A76">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Biffar, Reiner" sort="Biffar, Reiner" uniqKey="Biffar R" first="Reiner" last="Biffar">Reiner Biffar</name><affiliation><nlm:aff id="A94">Zentrum für Zahn-, Mund- und Kieferheilkunde, Greifswald, Germany.</nlm:aff></affiliation></author><author><name sortKey="Bonnycastle, Lori L" sort="Bonnycastle, Lori L" uniqKey="Bonnycastle L" first="Lori L" last="Bonnycastle">Lori L. Bonnycastle</name><affiliation><nlm:aff id="A81">National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Bornstein, Stefan R" sort="Bornstein, Stefan R" uniqKey="Bornstein S" first="Stefan R" last="Bornstein">Stefan R. Bornstein</name><affiliation><nlm:aff id="A95">Department of Medicine III, University of Dresden, Dresden, Germany.</nlm:aff></affiliation></author><author><name sortKey="Buchanan, Thomas A" sort="Buchanan, Thomas A" uniqKey="Buchanan T" first="Thomas A" last="Buchanan">Thomas A. Buchanan</name><affiliation><nlm:aff id="A87">Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A96">Division of Endocrinology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.</nlm:aff></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation><nlm:aff id="A97">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Day, Ian N M" sort="Day, Ian N M" uniqKey="Day I" first="Ian N M" last="Day">Ian N M. Day</name><affiliation><nlm:aff id="A86">MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, Oakfield House, Bristol, UK.</nlm:aff></affiliation></author><author><name sortKey="Dei, Mariano" sort="Dei, Mariano" uniqKey="Dei M" first="Mariano" last="Dei">Mariano Dei</name><affiliation><nlm:aff id="A79">Istituto di Neurogenetica e Neurofarmacologia del CNR, Monserrato, Cagliari, Italy.</nlm:aff></affiliation></author><author><name sortKey="Dorr, Marcus" sort="Dorr, Marcus" uniqKey="Dorr M" first="Marcus" last="Dörr">Marcus Dörr</name><affiliation><nlm:aff id="A98">Department of Internal Medicine B, Ernst-Moritz-Arndt University, Greifswald, Germany.</nlm:aff></affiliation></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation><nlm:aff id="A59">Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A99">MRC-Health Protection Agency (HPA) Centre for Environment and Health, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Erdos, Michael R" sort="Erdos, Michael R" uniqKey="Erdos M" first="Michael R" last="Erdos">Michael R. Erdos</name><affiliation><nlm:aff id="A81">National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G" last="Eriksson">Johan G. Eriksson</name><affiliation><nlm:aff id="A100">Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A104">Vasa Central Hospital, Vasa, Finland.</nlm:aff></affiliation></author><author><name sortKey="Freimer, Nelson B" sort="Freimer, Nelson B" uniqKey="Freimer N" first="Nelson B" last="Freimer">Nelson B. Freimer</name><affiliation><nlm:aff id="A105">Center for Neurobehavioral Genetics, University of California, Los Angeles, California, USA.</nlm:aff></affiliation></author><author><name sortKey="Fu, Mao" sort="Fu, Mao" uniqKey="Fu M" first="Mao" last="Fu">Mao Fu</name><affiliation><nlm:aff id="A106">Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Gaget, Stefan" sort="Gaget, Stefan" uniqKey="Gaget S" first="Stefan" last="Gaget">Stefan Gaget</name><affiliation><nlm:aff id="A13">Centre National de la Recherche Scientifique (CNRS), UMR8199-IBL-Institut Pasteur de Lille, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A14">University Lille Nord de France, Lille, France.</nlm:aff></affiliation></author><author><name sortKey="Geus, Eco J C" sort="Geus, Eco J C" uniqKey="Geus E" first="Eco J C" last="Geus">Eco J C. Geus</name><affiliation><nlm:aff id="A64">Department of Biological Psychology, Vrije Universiteit (VU) University Amsterdam, Amsterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Gjesing, Anette P" sort="Gjesing, Anette P" uniqKey="Gjesing A" first="Anette P" last="Gjesing">Anette P. Gjesing</name><affiliation><nlm:aff id="A84">Hagedorn Research Institute, Gentofte, Denmark.</nlm:aff></affiliation></author><author><name sortKey="Grallert, Harald" sort="Grallert, Harald" uniqKey="Grallert H" first="Harald" last="Grallert">Harald Grallert</name><affiliation><nlm:aff id="A2">Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Gr Ler, Jurgen" sort="Gr Ler, Jurgen" uniqKey="Gr Ler J" first="Jürgen" last="Gr Ler">Jürgen Gr Ler</name><affiliation><nlm:aff id="A107">Department of Medicine III, Pathobiochemistry, University of Dresden, Dresden, Germany.</nlm:aff></affiliation></author><author><name sortKey="Groves, Christopher J" sort="Groves, Christopher J" uniqKey="Groves C" first="Christopher J" last="Groves">Christopher J. Groves</name><affiliation><nlm:aff id="A76">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Guiducci, Candace" sort="Guiducci, Candace" uniqKey="Guiducci C" first="Candace" last="Guiducci">Candace Guiducci</name><affiliation><nlm:aff id="A10">Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation><nlm:aff id="A108">Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, Oulu, Finland.</nlm:aff></affiliation></author><author><name sortKey="Hassanali, Neelam" sort="Hassanali, Neelam" uniqKey="Hassanali N" first="Neelam" last="Hassanali">Neelam Hassanali</name><affiliation><nlm:aff id="A76">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Havulinna, Aki S" sort="Havulinna, Aki S" uniqKey="Havulinna A" first="Aki S" last="Havulinna">Aki S. Havulinna</name><affiliation><nlm:aff id="A109">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Chronic Disease Epidemiology and Prevention Unit, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Herzig, Karl Heinz" sort="Herzig, Karl Heinz" uniqKey="Herzig K" first="Karl-Heinz" last="Herzig">Karl-Heinz Herzig</name><affiliation><nlm:aff id="A70">Biocenter Oulu, University of Oulu, Oulu, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A110">Institute of Biomedicine, Department of Physiology, University of Oulu, Oulu, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A111">Department of Psychiatry, Kuopio University Hospital and University of Kuopio, Kuopio, Finland.</nlm:aff></affiliation></author><author><name sortKey="Hicks, Andrew A" sort="Hicks, Andrew A" uniqKey="Hicks A" first="Andrew A" last="Hicks">Andrew A. Hicks</name><affiliation><nlm:aff id="A112">Institute of Genetic Medicine, European Academy Bozen-Bolzano (EURAC), Bolzano-Bozen, Italy (affiliated Institute of the University of Lübeck, Lübeck, Germany).</nlm:aff></affiliation></author><author><name sortKey="Hui, Jennie" sort="Hui, Jennie" uniqKey="Hui J" first="Jennie" last="Hui">Jennie Hui</name><affiliation><nlm:aff id="A90">Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Crawley, Western Australia, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A113">PathWest Laboratory of Western Australia, Department of Molecular Genetics, J Block, QEII Medical Centre, Nedlands, Western Australia, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A114">Busselton Population Medical Research Foundation Inc., Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.</nlm:aff></affiliation></author><author><name sortKey="Igl, Wilmar" sort="Igl, Wilmar" uniqKey="Igl W" first="Wilmar" last="Igl">Wilmar Igl</name><affiliation><nlm:aff id="A65">Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, Uppsala, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Jousilahti, Pekka" sort="Jousilahti, Pekka" uniqKey="Jousilahti P" first="Pekka" last="Jousilahti">Pekka Jousilahti</name><affiliation><nlm:aff id="A109">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Chronic Disease Epidemiology and Prevention Unit, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Jula, Antti" sort="Jula, Antti" uniqKey="Jula A" first="Antti" last="Jula">Antti Jula</name><affiliation><nlm:aff id="A115">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Population Studies Unit, Turku, Finland.</nlm:aff></affiliation></author><author><name sortKey="Kajantie, Eero" sort="Kajantie, Eero" uniqKey="Kajantie E" first="Eero" last="Kajantie">Eero Kajantie</name><affiliation><nlm:aff id="A101">National Institute for Health and Welfare, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A116">Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Kinnunen, Leena" sort="Kinnunen, Leena" uniqKey="Kinnunen L" first="Leena" last="Kinnunen">Leena Kinnunen</name><affiliation><nlm:aff id="A117">National Institute for Health and Welfare, Diabetes Prevention Unit, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Kolcic, Ivana" sort="Kolcic, Ivana" uniqKey="Kolcic I" first="Ivana" last="Kolcic">Ivana Kolcic</name><affiliation><nlm:aff id="A74">Andrija Stampar School of Public Health, Medical School, University of Zagreb, Zagreb, Croatia.</nlm:aff></affiliation></author><author><name sortKey="Koskinen, Seppo" sort="Koskinen, Seppo" uniqKey="Koskinen S" first="Seppo" last="Koskinen">Seppo Koskinen</name><affiliation><nlm:aff id="A109">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Chronic Disease Epidemiology and Prevention Unit, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Kovacs, Peter" sort="Kovacs, Peter" uniqKey="Kovacs P" first="Peter" last="Kovacs">Peter Kovacs</name><affiliation><nlm:aff id="A118">Interdisciplinary Centre for Clinical Research, University of Leipzig, Leipzig, Germany.</nlm:aff></affiliation></author><author><name sortKey="Kroemer, Heyo K" sort="Kroemer, Heyo K" uniqKey="Kroemer H" first="Heyo K" last="Kroemer">Heyo K. Kroemer</name><affiliation><nlm:aff id="A119">Institut für Pharmakologie, Universität Greifswald, Greifswald, Germany.</nlm:aff></affiliation></author><author><name sortKey="Krzelj, Vjekoslav" sort="Krzelj, Vjekoslav" uniqKey="Krzelj V" first="Vjekoslav" last="Krzelj">Vjekoslav Krzelj</name><affiliation><nlm:aff id="A120">Croatian Centre for Global Health, School of Medicine, University of Split, Split, Croatia.</nlm:aff></affiliation></author><author><name sortKey="Kuusisto, Johanna" sort="Kuusisto, Johanna" uniqKey="Kuusisto J" first="Johanna" last="Kuusisto">Johanna Kuusisto</name><affiliation><nlm:aff id="A121">Department of Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland.</nlm:aff></affiliation></author><author><name sortKey="Kvaloy, Kirsti" sort="Kvaloy, Kirsti" uniqKey="Kvaloy K" first="Kirsti" last="Kvaloy">Kirsti Kvaloy</name><affiliation><nlm:aff id="A122">Nord-Trøndelag Health Study (HUNT) Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.</nlm:aff></affiliation></author><author><name sortKey="Laitinen, Jaana" sort="Laitinen, Jaana" uniqKey="Laitinen J" first="Jaana" last="Laitinen">Jaana Laitinen</name><affiliation><nlm:aff id="A123">Finnish Institute of Occupational Health, Oulu, Finland.</nlm:aff></affiliation></author><author><name sortKey="Lantieri, Olivier" sort="Lantieri, Olivier" uniqKey="Lantieri O" first="Olivier" last="Lantieri">Olivier Lantieri</name><affiliation><nlm:aff id="A124">Institut inter-regional pour la sante (IRSA), La Riche, France.</nlm:aff></affiliation></author><author><name sortKey="Lathrop, G Mark" sort="Lathrop, G Mark" uniqKey="Lathrop G" first="G Mark" last="Lathrop">G Mark Lathrop</name><affiliation><nlm:aff id="A125">Centre National de Genotypage, Evry, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Lokki, Marja Liisa" sort="Lokki, Marja Liisa" uniqKey="Lokki M" first="Marja-Liisa" last="Lokki">Marja-Liisa Lokki</name><affiliation><nlm:aff id="A126">Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Luben, Robert N" sort="Luben, Robert N" uniqKey="Luben R" first="Robert N" last="Luben">Robert N. Luben</name><affiliation><nlm:aff id="A127">Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Ludwig, Barbara" sort="Ludwig, Barbara" uniqKey="Ludwig B" first="Barbara" last="Ludwig">Barbara Ludwig</name><affiliation><nlm:aff id="A95">Department of Medicine III, University of Dresden, Dresden, Germany.</nlm:aff></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L" last="Mcardle">Wendy L. Mcardle</name><affiliation><nlm:aff id="A128">Avon Longitudinal Study of Parents and Children (ALSPAC) Laboratory, Department of Social Medicine, University of Bristol, Bristol, UK.</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Anne" sort="Mccarthy, Anne" uniqKey="Mccarthy A" first="Anne" last="Mccarthy">Anne Mccarthy</name><affiliation><nlm:aff id="A129">Division of Health, Research Board, An Bord Taighde Sláinte, Dublin, Ireland.</nlm:aff></affiliation></author><author><name sortKey="Morken, Mario A" sort="Morken, Mario A" uniqKey="Morken M" first="Mario A" last="Morken">Mario A. Morken</name><affiliation><nlm:aff id="A81">National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Nelis, Mari" sort="Nelis, Mari" uniqKey="Nelis M" first="Mari" last="Nelis">Mari Nelis</name><affiliation><nlm:aff id="A21">Estonian Genome Center, University of Tartu, Tartu, Estonia.</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.</nlm:aff></affiliation></author><author><name sortKey="Neville, Matt J" sort="Neville, Matt J" uniqKey="Neville M" first="Matt J" last="Neville">Matt J. Neville</name><affiliation><nlm:aff id="A76">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Pare, Guillaume" sort="Pare, Guillaume" uniqKey="Pare G" first="Guillaume" last="Paré">Guillaume Paré</name><affiliation><nlm:aff id="A130">Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.</nlm:aff></affiliation></author><author><name sortKey="Parker, Alex N" sort="Parker, Alex N" uniqKey="Parker A" first="Alex N" last="Parker">Alex N. Parker</name><affiliation><nlm:aff id="A131">Amgen, Cambridge, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Peden, John F" sort="Peden, John F" uniqKey="Peden J" first="John F" last="Peden">John F. Peden</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A132">Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Pichler, Irene" sort="Pichler, Irene" uniqKey="Pichler I" first="Irene" last="Pichler">Irene Pichler</name><affiliation><nlm:aff id="A112">Institute of Genetic Medicine, European Academy Bozen-Bolzano (EURAC), Bolzano-Bozen, Italy (affiliated Institute of the University of Lübeck, Lübeck, Germany).</nlm:aff></affiliation></author><author><name sortKey="Pietil Inen, Kirsi H" sort="Pietil Inen, Kirsi H" uniqKey="Pietil Inen K" first="Kirsi H" last="Pietil Inen">Kirsi H. Pietil Inen</name><affiliation><nlm:aff id="A133">Finnish Twin Cohort Study, Department of Public Health, University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A134">Obesity Research Unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Platou, Carl G P" sort="Platou, Carl G P" uniqKey="Platou C" first="Carl G P" last="Platou">Carl G P. Platou</name><affiliation><nlm:aff id="A122">Nord-Trøndelag Health Study (HUNT) Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.</nlm:aff></affiliation><affiliation><nlm:aff id="A135">Department of Medicine, Levanger Hospital, The Nord-Trøndelag Health Trust, Levanger, Norway.</nlm:aff></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><affiliation><nlm:aff id="A108">Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, Oulu, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A136">National Institute for Health and Welfare, Oulu, Finland.</nlm:aff></affiliation></author><author><name sortKey="Ridderstr Le, Martin" sort="Ridderstr Le, Martin" uniqKey="Ridderstr Le M" first="Martin" last="Ridderstr Le">Martin Ridderstr Le</name><affiliation><nlm:aff id="A137">Department of Clinical Sciences, Lund University, Malmö, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J" last="Samani">Nilesh J. Samani</name><affiliation><nlm:aff id="A138">Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A139">Leicester National Institute for Health Research (NIHR) Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, UK.</nlm:aff></affiliation></author><author><name sortKey="Saramies, Jouko" sort="Saramies, Jouko" uniqKey="Saramies J" first="Jouko" last="Saramies">Jouko Saramies</name><affiliation><nlm:aff id="A140">South Karelia Central Hospital, Lappeenranta, Finland.</nlm:aff></affiliation></author><author><name sortKey="Sinisalo, Juha" sort="Sinisalo, Juha" uniqKey="Sinisalo J" first="Juha" last="Sinisalo">Juha Sinisalo</name><affiliation><nlm:aff id="A141">Division of Cardiology, Cardiovascular Laboratory, Helsinki University Central Hospital, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Smit, Jan H" sort="Smit, Jan H" uniqKey="Smit J" first="Jan H" last="Smit">Jan H. Smit</name><affiliation><nlm:aff id="A142">Department of Psychiatry/Instituut voor Extramuraal Geneeskundig Onderzoek (EMGO) Institute, VU University Medical Center, Amsterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Strawbridge, Rona J" sort="Strawbridge, Rona J" uniqKey="Strawbridge R" first="Rona J" last="Strawbridge">Rona J. Strawbridge</name><affiliation><nlm:aff id="A143">Atherosclerosis Research Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Stringham, Heather M" sort="Stringham, Heather M" uniqKey="Stringham H" first="Heather M" last="Stringham">Heather M. Stringham</name><affiliation><nlm:aff id="A3">Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.</nlm:aff></affiliation></author><author><name sortKey="Swift, Amy J" sort="Swift, Amy J" uniqKey="Swift A" first="Amy J" last="Swift">Amy J. Swift</name><affiliation><nlm:aff id="A81">National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Teder Laving, Maris" sort="Teder Laving, Maris" uniqKey="Teder Laving M" first="Maris" last="Teder-Laving">Maris Teder-Laving</name><affiliation><nlm:aff id="A22">Estonian Biocenter, Tartu, Estonia.</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.</nlm:aff></affiliation></author><author><name sortKey="Thomson, Brian" sort="Thomson, Brian" uniqKey="Thomson B" first="Brian" last="Thomson">Brian Thomson</name><affiliation><nlm:aff id="A10">Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Usala, Gianluca" sort="Usala, Gianluca" uniqKey="Usala G" first="Gianluca" last="Usala">Gianluca Usala</name><affiliation><nlm:aff id="A79">Istituto di Neurogenetica e Neurofarmacologia del CNR, Monserrato, Cagliari, Italy.</nlm:aff></affiliation></author><author><name sortKey="Van Meurs, Joyce B J" sort="Van Meurs, Joyce B J" uniqKey="Van Meurs J" first="Joyce B J" last="Van Meurs">Joyce B J. Van Meurs</name><affiliation><nlm:aff id="A8">Department of Internal Medicine, Erasmus Medical Center (MC), Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A43">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Van Ommen, Gert Jan" sort="Van Ommen, Gert Jan" uniqKey="Van Ommen G" first="Gert-Jan" last="Van Ommen">Gert-Jan Van Ommen</name><affiliation><nlm:aff id="A144">Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A145">Center of Medical Systems Biology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Vatin, Vincent" sort="Vatin, Vincent" uniqKey="Vatin V" first="Vincent" last="Vatin">Vincent Vatin</name><affiliation><nlm:aff id="A13">Centre National de la Recherche Scientifique (CNRS), UMR8199-IBL-Institut Pasteur de Lille, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A14">University Lille Nord de France, Lille, France.</nlm:aff></affiliation></author><author><name sortKey="Volpato, Claudia B" sort="Volpato, Claudia B" uniqKey="Volpato C" first="Claudia B" last="Volpato">Claudia B. Volpato</name><affiliation><nlm:aff id="A112">Institute of Genetic Medicine, European Academy Bozen-Bolzano (EURAC), Bolzano-Bozen, Italy (affiliated Institute of the University of Lübeck, Lübeck, Germany).</nlm:aff></affiliation></author><author><name sortKey="Wallaschofski, Henri" sort="Wallaschofski, Henri" uniqKey="Wallaschofski H" first="Henri" last="Wallaschofski">Henri Wallaschofski</name><affiliation><nlm:aff id="A146">Institut für Klinische Chemie und Laboratoriumsmedizin, Universität Greifswald, Greifswald, Germany.</nlm:aff></affiliation></author><author><name sortKey="Walters, G Bragi" sort="Walters, G Bragi" uniqKey="Walters G" first="G Bragi" last="Walters">G Bragi Walters</name><affiliation><nlm:aff id="A7">deCODE Genetics, Reykjavik, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widen">Elisabeth Widen</name><affiliation><nlm:aff id="A77">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H" last="Wild">Sarah H. Wild</name><affiliation><nlm:aff id="A97">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation><nlm:aff id="A64">Department of Biological Psychology, Vrije Universiteit (VU) University Amsterdam, Amsterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Witte, Daniel R" sort="Witte, Daniel R" uniqKey="Witte D" first="Daniel R" last="Witte">Daniel R. Witte</name><affiliation><nlm:aff id="A147">Steno Diabetes Center, Gentofte, Denmark.</nlm:aff></affiliation></author><author><name sortKey="Zgaga, Lina" sort="Zgaga, Lina" uniqKey="Zgaga L" first="Lina" last="Zgaga">Lina Zgaga</name><affiliation><nlm:aff id="A74">Andrija Stampar School of Public Health, Medical School, University of Zagreb, Zagreb, Croatia.</nlm:aff></affiliation></author><author><name sortKey="Zitting, Paavo" sort="Zitting, Paavo" uniqKey="Zitting P" first="Paavo" last="Zitting">Paavo Zitting</name><affiliation><nlm:aff id="A148">Department of Physiatrics, Lapland Central Hospital, Rovaniemi, Finland.</nlm:aff></affiliation></author><author><name sortKey="Beilby, John P" sort="Beilby, John P" uniqKey="Beilby J" first="John P" last="Beilby">John P. Beilby</name><affiliation><nlm:aff id="A113">PathWest Laboratory of Western Australia, Department of Molecular Genetics, J Block, QEII Medical Centre, Nedlands, Western Australia, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A114">Busselton Population Medical Research Foundation Inc., Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A149">School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Western Australia, Australia.</nlm:aff></affiliation></author><author><name sortKey="James, Alan L" sort="James, Alan L" uniqKey="James A" first="Alan L" last="James">Alan L. James</name><affiliation><nlm:aff id="A114">Busselton Population Medical Research Foundation Inc., Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A150">School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia.</nlm:aff></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation><nlm:aff id="A151">Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland.</nlm:aff></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation><nlm:aff id="A152">Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Tampere, Finland.</nlm:aff></affiliation></author><author><name sortKey="Nieminen, Markku S" sort="Nieminen, Markku S" uniqKey="Nieminen M" first="Markku S" last="Nieminen">Markku S. Nieminen</name><affiliation><nlm:aff id="A141">Division of Cardiology, Cardiovascular Laboratory, Helsinki University Central Hospital, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Ohlsson, Claes" sort="Ohlsson, Claes" uniqKey="Ohlsson C" first="Claes" last="Ohlsson">Claes Ohlsson</name><affiliation><nlm:aff id="A92">Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J" last="Palmer">Lyle J. Palmer</name><affiliation><nlm:aff id="A90">Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Crawley, Western Australia, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A114">Busselton Population Medical Research Foundation Inc., Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.</nlm:aff></affiliation></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><affiliation><nlm:aff id="A153">Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A154">The Department of Clinical Physiology, Turku University Hospital, Turku, Finland.</nlm:aff></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name><affiliation><nlm:aff id="A30">Harvard Medical School, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A89">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name><affiliation><nlm:aff id="A155">Department of Medicine, University of Leipzig, Leipzig, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A156">Leipziger Interdisziplinärer Forschungskomplex zu molekularen Ursachen umwelt- und lebensstilassoziierter Erkrankungen (LIFE) Study Centre, University of Leipzig, Leipzig, Germany.</nlm:aff></affiliation></author><author><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tönjes">Anke Tönjes</name><affiliation><nlm:aff id="A155">Department of Medicine, University of Leipzig, Leipzig, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A157">Coordination Centre for Clinical Trials, University of Leipzig, Leipzig, Germany.</nlm:aff></affiliation></author><author><name sortKey="Viikari, Jorma" sort="Viikari, Jorma" uniqKey="Viikari J" first="Jorma" last="Viikari">Jorma Viikari</name><affiliation><nlm:aff id="A158">Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland.</nlm:aff></affiliation></author><author><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name><affiliation><nlm:aff id="A159">INSERM Centre de Recherche en Epidémiologie et Santé des Populations (CESP) U1018, Villejuif, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A160">University Paris Sud 11, Unité Mixte de Recherche en Santé (UMRS) 1018, Villejuif, France.</nlm:aff></affiliation></author><author><name sortKey="Ben Shlomo, Yoav" sort="Ben Shlomo, Yoav" uniqKey="Ben Shlomo Y" first="Yoav" last="Ben-Shlomo">Yoav Ben-Shlomo</name><affiliation><nlm:aff id="A161">Department of Social Medicine, University of Bristol, Bristol, UK.</nlm:aff></affiliation></author><author><name sortKey="Bergman, Richard N" sort="Bergman, Richard N" uniqKey="Bergman R" first="Richard N" last="Bergman">Richard N. Bergman</name><affiliation><nlm:aff id="A87">Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.</nlm:aff></affiliation></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><affiliation><nlm:aff id="A82">Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.</nlm:aff></affiliation></author><author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name><affiliation><nlm:aff id="A86">MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, Oakfield House, Bristol, UK.</nlm:aff></affiliation></author><author><name sortKey="Ebrahim, Shah" sort="Ebrahim, Shah" uniqKey="Ebrahim S" first="Shah" last="Ebrahim">Shah Ebrahim</name><affiliation><nlm:aff id="A162">The London School of Hygiene and Tropical Medicine, London, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A163">South Asia Network for Chronic Disease, New Delhi, India.</nlm:aff></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation><nlm:aff id="A13">Centre National de la Recherche Scientifique (CNRS), UMR8199-IBL-Institut Pasteur de Lille, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A14">University Lille Nord de France, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A164">Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Hansen, Torben" sort="Hansen, Torben" uniqKey="Hansen T" first="Torben" last="Hansen">Torben Hansen</name><affiliation><nlm:aff id="A84">Hagedorn Research Institute, Gentofte, Denmark.</nlm:aff></affiliation><affiliation><nlm:aff id="A165">Faculty of Health Science, University of Southern Denmark, Odense, Denmark.</nlm:aff></affiliation></author><author><name sortKey="Hengstenberg, Christian" sort="Hengstenberg, Christian" uniqKey="Hengstenberg C" first="Christian" last="Hengstenberg">Christian Hengstenberg</name><affiliation><nlm:aff id="A166">Klinik und Poliklinik für Innere Medizin II, Universität Regensburg, Regensburg, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A167">Regensburg University Medical Center, Innere Medizin II, Regensburg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Hveem, Kristian" sort="Hveem, Kristian" uniqKey="Hveem K" first="Kristian" last="Hveem">Kristian Hveem</name><affiliation><nlm:aff id="A122">Nord-Trøndelag Health Study (HUNT) Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.</nlm:aff></affiliation></author><author><name sortKey="Isomaa, Bo" sort="Isomaa, Bo" uniqKey="Isomaa B" first="Bo" last="Isomaa">Bo Isomaa</name><affiliation><nlm:aff id="A103">Folkhalsan Research Centre, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A168">Department of Social Services and Health Care, Jakobstad, Finland.</nlm:aff></affiliation></author><author><name sortKey="J Rgensen, Torben" sort="J Rgensen, Torben" uniqKey="J Rgensen T" first="Torben" last="J Rgensen">Torben J Rgensen</name><affiliation><nlm:aff id="A169">Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark.</nlm:aff></affiliation><affiliation><nlm:aff id="A170">Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.</nlm:aff></affiliation></author><author><name sortKey="Karpe, Fredrik" sort="Karpe, Fredrik" uniqKey="Karpe F" first="Fredrik" last="Karpe">Fredrik Karpe</name><affiliation><nlm:aff id="A76">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A171">NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation><nlm:aff id="A127">Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Laakso, Markku" sort="Laakso, Markku" uniqKey="Laakso M" first="Markku" last="Laakso">Markku Laakso</name><affiliation><nlm:aff id="A121">Department of Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland.</nlm:aff></affiliation></author><author><name sortKey="Lawlor, Debbie A" sort="Lawlor, Debbie A" uniqKey="Lawlor D" first="Debbie A" last="Lawlor">Debbie A. Lawlor</name><affiliation><nlm:aff id="A86">MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, Oakfield House, Bristol, UK.</nlm:aff></affiliation></author><author><name sortKey="Marre, Michel" sort="Marre, Michel" uniqKey="Marre M" first="Michel" last="Marre">Michel Marre</name><affiliation><nlm:aff id="A172">Department of Endocrinology, Diabetology and Nutrition, Bichat-Claude Bernard University Hospital, Assistance Publique des Hôpitaux de Paris, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A173">Cardiovascular Genetics Research Unit, Université Henri Poincaré-Nancy 1, Nancy, France.</nlm:aff></affiliation></author><author><name sortKey="Meitinger, Thomas" sort="Meitinger, Thomas" uniqKey="Meitinger T" first="Thomas" last="Meitinger">Thomas Meitinger</name><affiliation><nlm:aff id="A174">Institute of Human Genetics, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A175">Institute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation><nlm:aff id="A21">Estonian Genome Center, University of Tartu, Tartu, Estonia.</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.</nlm:aff></affiliation></author><author><name sortKey="Midthjell, Kristian" sort="Midthjell, Kristian" uniqKey="Midthjell K" first="Kristian" last="Midthjell">Kristian Midthjell</name><affiliation><nlm:aff id="A122">Nord-Trøndelag Health Study (HUNT) Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.</nlm:aff></affiliation></author><author><name sortKey="Pedersen, Oluf" sort="Pedersen, Oluf" uniqKey="Pedersen O" first="Oluf" last="Pedersen">Oluf Pedersen</name><affiliation><nlm:aff id="A84">Hagedorn Research Institute, Gentofte, Denmark.</nlm:aff></affiliation><affiliation><nlm:aff id="A176">Institute of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:aff></affiliation><affiliation><nlm:aff id="A177">Faculty of Health Science, University of Aarhus, Aarhus, Denmark.</nlm:aff></affiliation></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name><affiliation><nlm:aff id="A109">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Chronic Disease Epidemiology and Prevention Unit, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Schwarz, Peter E H" sort="Schwarz, Peter E H" uniqKey="Schwarz P" first="Peter E H" last="Schwarz">Peter E H. Schwarz</name><affiliation><nlm:aff id="A178">Department of Medicine III, Prevention and Care of Diabetes, University of Dresden, Dresden, Germany.</nlm:aff></affiliation></author><author><name sortKey="Tuomi, Tiinamaija" sort="Tuomi, Tiinamaija" uniqKey="Tuomi T" first="Tiinamaija" last="Tuomi">Tiinamaija Tuomi</name><affiliation><nlm:aff id="A103">Folkhalsan Research Centre, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A179">Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A180">Research Program of Molecular Medicine, University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Tuomilehto, Jaakko" sort="Tuomilehto, Jaakko" uniqKey="Tuomilehto J" first="Jaakko" last="Tuomilehto">Jaakko Tuomilehto</name><affiliation><nlm:aff id="A117">National Institute for Health and Welfare, Diabetes Prevention Unit, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A181">Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A182">South Ostrobothnia Central Hospital, Seinajoki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Valle, Timo T" sort="Valle, Timo T" uniqKey="Valle T" first="Timo T" last="Valle">Timo T. Valle</name><affiliation><nlm:aff id="A117">National Institute for Health and Welfare, Diabetes Prevention Unit, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="A19">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Arnold, Alice M" sort="Arnold, Alice M" uniqKey="Arnold A" first="Alice M" last="Arnold">Alice M. Arnold</name><affiliation><nlm:aff id="A73">Department of Biostatistics, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A183">Collaborative Health Studies Coordinating Center, Seattle, Washington, USA.</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Jacques S" sort="Beckmann, Jacques S" uniqKey="Beckmann J" first="Jacques S" last="Beckmann">Jacques S. Beckmann</name><affiliation><nlm:aff id="A24">Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.</nlm:aff></affiliation><affiliation><nlm:aff id="A184">Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, Lausanne, Switzerland.</nlm:aff></affiliation></author><author><name sortKey="Bergmann, Sven" sort="Bergmann, Sven" uniqKey="Bergmann S" first="Sven" last="Bergmann">Sven Bergmann</name><affiliation><nlm:aff id="A24">Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.</nlm:aff></affiliation><affiliation><nlm:aff id="A25">Swiss Institute of Bioinformatics, Lausanne, Switzerland.</nlm:aff></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation><nlm:aff id="A185">Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas, USA.</nlm:aff></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I" last="Boomsma">Dorret I. Boomsma</name><affiliation><nlm:aff id="A64">Department of Biological Psychology, Vrije Universiteit (VU) University Amsterdam, Amsterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Caulfield, Mark J" sort="Caulfield, Mark J" uniqKey="Caulfield M" first="Mark J" last="Caulfield">Mark J. Caulfield</name><affiliation><nlm:aff id="A68">Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London UK.</nlm:aff></affiliation></author><author><name sortKey="Collins, Francis S" sort="Collins, Francis S" uniqKey="Collins F" first="Francis S" last="Collins">Francis S. Collins</name><affiliation><nlm:aff id="A81">National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation><nlm:aff id="A53">Icelandic Heart Association, Kopavogur, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:aff id="A53">Icelandic Heart Association, Kopavogur, Iceland.</nlm:aff></affiliation><affiliation><nlm:aff id="A54">University of Iceland, Reykjavik, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation><nlm:aff id="A65">Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, Uppsala, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Hamsten, Anders" sort="Hamsten, Anders" uniqKey="Hamsten A" first="Anders" last="Hamsten">Anders Hamsten</name><affiliation><nlm:aff id="A143">Atherosclerosis Research Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Hattersley, Andrew T" sort="Hattersley, Andrew T" uniqKey="Hattersley A" first="Andrew T" last="Hattersley">Andrew T. Hattersley</name><affiliation><nlm:aff id="A18">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK.</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="A9">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A43">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Hu, Frank B" sort="Hu, Frank B" uniqKey="Hu F" first="Frank B" last="Hu">Frank B. Hu</name><affiliation><nlm:aff id="A5">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A32">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><affiliation><nlm:aff id="A2">Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Iribarren, Carlos" sort="Iribarren, Carlos" uniqKey="Iribarren C" first="Carlos" last="Iribarren">Carlos Iribarren</name><affiliation><nlm:aff id="A186">Division of Research, Kaiser Permanente Northern California, Oakland, California, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A187">Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.</nlm:aff></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation><nlm:aff id="A59">Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A69">Institute of Health Sciences, University of Oulu, Oulu, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A70">Biocenter Oulu, University of Oulu, Oulu, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A136">National Institute for Health and Welfare, Oulu, Finland.</nlm:aff></affiliation></author><author><name sortKey="Kao, W H Linda" sort="Kao, W H Linda" uniqKey="Kao W" first="W H Linda" last="Kao">W H Linda Kao</name><affiliation><nlm:aff id="A188">Department of Epidemiology and Medicine, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><affiliation><nlm:aff id="A77">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A133">Finnish Twin Cohort Study, Department of Public Health, University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A189">National Institute for Health and Welfare, Department of Mental Health and Substance Abuse Services, Unit for Child and Adolescent Mental Health, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name><affiliation><nlm:aff id="A15">Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Munroe, Patricia B" sort="Munroe, Patricia B" uniqKey="Munroe P" first="Patricia B" last="Munroe">Patricia B. Munroe</name><affiliation><nlm:aff id="A68">Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London UK.</nlm:aff></affiliation></author><author><name sortKey="Oostra, Ben" sort="Oostra, Ben" uniqKey="Oostra B" first="Ben" last="Oostra">Ben Oostra</name><affiliation><nlm:aff id="A190">Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W" last="Penninx">Brenda W. Penninx</name><affiliation><nlm:aff id="A142">Department of Psychiatry/Instituut voor Extramuraal Geneeskundig Onderzoek (EMGO) Institute, VU University Medical Center, Amsterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A191">Department of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A192">Department of Psychiatry, University Medical Centre Groningen, Groningen, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P" last="Pramstaller">Peter P. Pramstaller</name><affiliation><nlm:aff id="A112">Institute of Genetic Medicine, European Academy Bozen-Bolzano (EURAC), Bolzano-Bozen, Italy (affiliated Institute of the University of Lübeck, Lübeck, Germany).</nlm:aff></affiliation><affiliation><nlm:aff id="A193">Department of Neurology, General Central Hospital, Bolzano, Italy.</nlm:aff></affiliation><affiliation><nlm:aff id="A194">Department of Neurology, University of Lübeck, Lübeck, Germany.</nlm:aff></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M" last="Psaty">Bruce M. Psaty</name><affiliation><nlm:aff id="A195">Departments of Epidemiology, Medicine and Health Services, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A196">Group Health Research Institute, Group Health, Seattle, Washington, USA.</nlm:aff></affiliation></author><author><name sortKey="Quertermous, Thomas" sort="Quertermous, Thomas" uniqKey="Quertermous T" first="Thomas" last="Quertermous">Thomas Quertermous</name><affiliation><nlm:aff id="A71">Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</nlm:aff></affiliation></author><author><name sortKey="Rissanen, Aila" sort="Rissanen, Aila" uniqKey="Rissanen A" first="Aila" last="Rissanen">Aila Rissanen</name><affiliation><nlm:aff id="A134">Obesity Research Unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation><nlm:aff id="A97">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A120">Croatian Centre for Global Health, School of Medicine, University of Split, Split, Croatia.</nlm:aff></affiliation></author><author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R" last="Shuldiner">Alan R. Shuldiner</name><affiliation><nlm:aff id="A106">Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A197">Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation><nlm:aff id="A41">Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D" last="Spector">Timothy D. Spector</name><affiliation><nlm:aff id="A48">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Syvanen, Ann Christine" sort="Syvanen, Ann Christine" uniqKey="Syvanen A" first="Ann-Christine" last="Syvanen">Ann-Christine Syvanen</name><affiliation><nlm:aff id="A198">Uppsala University, Department of Medical Sciences, Molecular Medicine, Uppsala, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Uda, Manuela" sort="Uda, Manuela" uniqKey="Uda M" first="Manuela" last="Uda">Manuela Uda</name><affiliation><nlm:aff id="A79">Istituto di Neurogenetica e Neurofarmacologia del CNR, Monserrato, Cagliari, Italy.</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre" sort="Uitterlinden, Andre" uniqKey="Uitterlinden A" first="André" last="Uitterlinden">André Uitterlinden</name><affiliation><nlm:aff id="A8">Department of Internal Medicine, Erasmus Medical Center (MC), Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A43">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation><nlm:aff id="A199">Institut für Community Medicine, Greifswald, Germany.</nlm:aff></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation><nlm:aff id="A200">Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, Lausanne, Switzerland.</nlm:aff></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F" last="Wilson">James F. Wilson</name><affiliation><nlm:aff id="A97">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Witteman, Jacqueline C" sort="Witteman, Jacqueline C" uniqKey="Witteman J" first="Jacqueline C" last="Witteman">Jacqueline C. Witteman</name><affiliation><nlm:aff id="A9">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A43">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F" last="Wright">Alan F. Wright</name><affiliation><nlm:aff id="A62">MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Abecasis, Goncalo R" sort="Abecasis, Goncalo R" uniqKey="Abecasis G" first="Gonçalo R" last="Abecasis">Gonçalo R. Abecasis</name><affiliation><nlm:aff id="A3">Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.</nlm:aff></affiliation></author><author><name sortKey="Boehnke, Michael" sort="Boehnke, Michael" uniqKey="Boehnke M" first="Michael" last="Boehnke">Michael Boehnke</name><affiliation><nlm:aff id="A3">Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.</nlm:aff></affiliation></author><author><name sortKey="Borecki, Ingrid B" sort="Borecki, Ingrid B" uniqKey="Borecki I" first="Ingrid B" last="Borecki">Ingrid B. Borecki</name><affiliation><nlm:aff id="A40">Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A201">Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA.</nlm:aff></affiliation></author><author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name><affiliation><nlm:aff id="A41">Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Frayling, Timothy M" sort="Frayling, Timothy M" uniqKey="Frayling T" first="Timothy M" last="Frayling">Timothy M. Frayling</name><affiliation><nlm:aff id="A18">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK.</nlm:aff></affiliation></author><author><name sortKey="Groop, Leif C" sort="Groop, Leif C" uniqKey="Groop L" first="Leif C" last="Groop">Leif C. Groop</name><affiliation><nlm:aff id="A93">Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Malmö, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Haritunians, Talin" sort="Haritunians, Talin" uniqKey="Haritunians T" first="Talin" last="Haritunians">Talin Haritunians</name><affiliation><nlm:aff id="A202">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.</nlm:aff></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name><affiliation><nlm:aff id="A5">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A32">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Kaplan, Robert C" sort="Kaplan, Robert C" uniqKey="Kaplan R" first="Robert C" last="Kaplan">Robert C. Kaplan</name><affiliation><nlm:aff id="A203">Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.</nlm:aff></affiliation></author><author><name sortKey="North, Kari E" sort="North, Kari E" uniqKey="North K" first="Kari E" last="North">Kari E. North</name><affiliation><nlm:aff id="A26">Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A204">Carolina Center for Genome Sciences, School of Public Health, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA.</nlm:aff></affiliation></author><author><name sortKey="O Onnell, Jeffrey R" sort="O Onnell, Jeffrey R" uniqKey="O Onnell J" first="Jeffrey R" last="O Onnell">Jeffrey R. O Onnell</name><affiliation><nlm:aff id="A106">Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Peltonen, Leena" sort="Peltonen, Leena" uniqKey="Peltonen L" first="Leena" last="Peltonen">Leena Peltonen</name><affiliation><nlm:aff id="A41">Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A51">The Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A77">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A101">National Institute for Health and Welfare, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A205">Department of Medical Genetics, University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Schlessinger, David" sort="Schlessinger, David" uniqKey="Schlessinger D" first="David" last="Schlessinger">David Schlessinger</name><affiliation><nlm:aff id="A206">Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P" last="Strachan">David P. Strachan</name><affiliation><nlm:aff id="A207">Division of Community Health Sciences, St George’s, University of London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N" last="Hirschhorn">Joel N. Hirschhorn</name><affiliation><nlm:aff id="A10">Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Divisions of Genetics and Endocrinology and Program in Genomics, Children’s Hospital, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A208">Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Assimes, Themistocles L" sort="Assimes, Themistocles L" uniqKey="Assimes T" first="Themistocles L" last="Assimes">Themistocles L. Assimes</name><affiliation><nlm:aff id="A71">Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</nlm:aff></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H-Erich" last="Wichmann">H-Erich Wichmann</name><affiliation><nlm:aff id="A2">Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A209">Klinikum Grosshadern, Munich, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A210">Ludwig-Maximilians-Universität, Institute of Medical Informatics, Biometry and Epidemiology, Munich, Germany.</nlm:aff></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation><nlm:aff id="A7">deCODE Genetics, Reykjavik, Iceland.</nlm:aff></affiliation><affiliation><nlm:aff id="A211">Faculty of Medicine, University of Iceland, Reykjavík, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:aff id="A9">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A43">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation><nlm:aff id="A7">deCODE Genetics, Reykjavik, Iceland.</nlm:aff></affiliation><affiliation><nlm:aff id="A211">Faculty of Medicine, University of Iceland, Reykjavík, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Cupples, L Adrienne" sort="Cupples, L Adrienne" uniqKey="Cupples L" first="L Adrienne" last="Cupples">L Adrienne Cupples</name><affiliation><nlm:aff id="A12">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J F" last="Loos">Ruth J F. Loos</name><affiliation><nlm:aff id="A19">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Barroso, Ines" sort="Barroso, Ines" uniqKey="Barroso I" first="Inês" last="Barroso">Inês Barroso</name><affiliation><nlm:aff id="A41">Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A212">University of Cambridge Metabolic Research Labs, Institute of Metabolic Science Addenbrooke’s Hospital, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I" last="Mccarthy">Mark I. Mccarthy</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A76">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A171">NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S" last="Fox">Caroline S. Fox</name><affiliation><nlm:aff id="A213">Division of Intramural Research, National Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Mohlke, Karen L" sort="Mohlke, Karen L" uniqKey="Mohlke K" first="Karen L" last="Mohlke">Karen L. Mohlke</name><affiliation><nlm:aff id="A83">Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.</nlm:aff></affiliation></author><author><name sortKey="Lindgren, Cecilia M" sort="Lindgren, Cecilia M" uniqKey="Lindgren C" first="Cecilia M" last="Lindgren">Cecilia M. Lindgren</name><affiliation><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A76">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P15">Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near <italic>RSPO3</italic>, <italic>VEGFA</italic>, <italic>TBX15-WARS2</italic>, <italic>NFE2L3</italic>, <italic>GRB14</italic>, <italic>DNM3-PIGC</italic>, <italic>ITPR2-SSPN</italic>, <italic>LY86</italic>, <italic>HOXC13</italic>, <italic>ADAMTS9</italic>, <italic>ZNRF3-KREMEN1</italic>, <italic>NISCH-STAB1</italic> and <italic>CPEB4</italic> (<italic>P</italic> = 1.9 × 10<sup>−9</sup> to <italic>P</italic> = 1.8 × 10<sup>−40</sup>) and the known signal at <italic>LYPLAL1</italic>. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (<italic>P</italic> for sex difference = 1.9 × 10<sup>−3</sup> to <italic>P</italic> = 1.2 × 10<sup>−13</sup>). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9216904</journal-id><journal-id journal-id-type="pubmed-jr-id">2419</journal-id><journal-id journal-id-type="nlm-ta">Nat Genet</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Genet.</journal-id><journal-title-group><journal-title>Nature genetics</journal-title></journal-title-group><issn pub-type="ppub">1061-4036</issn><issn pub-type="epub">1546-1718</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20935629</article-id><article-id pub-id-type="pmc">3000924</article-id><article-id pub-id-type="doi">10.1038/ng.685</article-id><article-id pub-id-type="manuscript">UKMS33585</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Heid</surname><given-names>Iris M</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="author-notes" 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ref-type="aff" rid="A204">204</xref></contrib><contrib contrib-type="author"><name><surname>O’connell</surname><given-names>Jeffrey R</given-names></name><xref ref-type="aff" rid="A106">106</xref></contrib><contrib contrib-type="author"><name><surname>Peltonen</surname><given-names>Leena</given-names></name><xref ref-type="aff" rid="A41">41</xref><xref ref-type="aff" rid="A51">51</xref><xref ref-type="aff" rid="A77">77</xref><xref ref-type="aff" rid="A101">101</xref><xref ref-type="aff" rid="A205">205</xref></contrib><contrib contrib-type="author"><name><surname>Schlessinger</surname><given-names>David</given-names></name><xref ref-type="aff" rid="A206">206</xref></contrib><contrib contrib-type="author"><name><surname>Strachan</surname><given-names>David P</given-names></name><xref ref-type="aff" rid="A207">207</xref></contrib><contrib contrib-type="author"><name><surname>Hirschhorn</surname><given-names>Joel N</given-names></name><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A20">20</xref><xref ref-type="aff" rid="A208">208</xref></contrib><contrib contrib-type="author"><name><surname>Assimes</surname><given-names>Themistocles L</given-names></name><xref ref-type="aff" rid="A71">71</xref></contrib><contrib contrib-type="author"><name><surname>Wichmann</surname><given-names>H-Erich</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A209">209</xref><xref ref-type="aff" rid="A210">210</xref></contrib><contrib contrib-type="author"><name><surname>Thorsteinsdottir</surname><given-names>Unnur</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A211">211</xref></contrib><contrib contrib-type="author"><name><surname>van Duijn</surname><given-names>Cornelia M</given-names></name><xref ref-type="aff" rid="A9">9</xref><xref ref-type="aff" rid="A43">43</xref></contrib><contrib contrib-type="author"><name><surname>Stefansson</surname><given-names>Kari</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A211">211</xref><xref ref-type="author-notes" rid="FN2">215</xref></contrib><contrib contrib-type="author"><name><surname>Cupples</surname><given-names>L Adrienne</given-names></name><xref ref-type="aff" rid="A12">12</xref><xref ref-type="author-notes" rid="FN2">215</xref></contrib><contrib contrib-type="author"><name><surname>Loos</surname><given-names>Ruth J F</given-names></name><xref ref-type="aff" rid="A19">19</xref><xref ref-type="author-notes" rid="FN2">215</xref></contrib><contrib contrib-type="author"><name><surname>Barroso</surname><given-names>Inês</given-names></name><xref ref-type="aff" rid="A41">41</xref><xref ref-type="aff" rid="A212">212</xref><xref ref-type="author-notes" rid="FN2">215</xref></contrib><contrib contrib-type="author"><name><surname>McCarthy</surname><given-names>Mark I</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A76">76</xref><xref ref-type="aff" rid="A171">171</xref><xref ref-type="author-notes" rid="FN2">215</xref></contrib><contrib contrib-type="author"><name><surname>Fox</surname><given-names>Caroline S</given-names></name><xref ref-type="aff" rid="A213">213</xref><xref ref-type="author-notes" rid="FN2">215</xref></contrib><contrib contrib-type="author"><name><surname>Mohlke</surname><given-names>Karen L</given-names></name><xref ref-type="aff" rid="A83">83</xref><xref ref-type="author-notes" rid="FN2">215</xref></contrib><contrib contrib-type="author"><name><surname>Lindgren</surname><given-names>Cecilia M</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A76">76</xref><xref ref-type="author-notes" rid="FN2">215</xref></contrib></contrib-group><aff id="A1"><label>1</label>Regensburg University Medical Center, Department of Epidemiology and Preventive Medicine, Regensburg, Germany.</aff><aff id="A2"><label>2</label>Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.</aff><aff id="A3"><label>3</label>Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.</aff><aff id="A4"><label>4</label>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</aff><aff id="A5"><label>5</label>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.</aff><aff id="A6"><label>6</label>Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.</aff><aff id="A7"><label>7</label>deCODE Genetics, Reykjavik, Iceland.</aff><aff id="A8"><label>8</label>Department of Internal Medicine, Erasmus Medical Center (MC), Rotterdam, The Netherlands.</aff><aff id="A9"><label>9</label>Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</aff><aff id="A10"><label>10</label>Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.</aff><aff id="A11"><label>11</label>Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA.</aff><aff id="A12"><label>12</label>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.</aff><aff id="A13"><label>13</label>Centre National de la Recherche Scientifique (CNRS), UMR8199-IBL-Institut Pasteur de Lille, Lille, France.</aff><aff id="A14"><label>14</label>University Lille Nord de France, Lille, France.</aff><aff id="A15"><label>15</label>Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.</aff><aff id="A16"><label>16</label>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA.</aff><aff id="A17"><label>17</label>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</aff><aff id="A18"><label>18</label>Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK.</aff><aff id="A19"><label>19</label>Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK.</aff><aff id="A20"><label>20</label>Divisions of Genetics and Endocrinology and Program in Genomics, Children’s Hospital, Boston, Massachusetts, USA.</aff><aff id="A21"><label>21</label>Estonian Genome Center, University of Tartu, Tartu, Estonia.</aff><aff id="A22"><label>22</label>Estonian Biocenter, Tartu, Estonia.</aff><aff id="A23"><label>23</label>Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.</aff><aff id="A24"><label>24</label>Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.</aff><aff id="A25"><label>25</label>Swiss Institute of Bioinformatics, Lausanne, Switzerland.</aff><aff id="A26"><label>26</label>Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.</aff><aff id="A27"><label>27</label>Department of Pharmacy and Pharmacology, University of Bath, Bath, UK.</aff><aff id="A28"><label>28</label>MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, UK.</aff><aff id="A29"><label>29</label>Department of Statistics, University of Oxford, Oxford, UK.</aff><aff id="A30"><label>30</label>Harvard Medical School, Boston, Massachusetts, USA.</aff><aff id="A31"><label>31</label>Massachusetts General Hospital (MGH) Weight Center, Massachusetts General Hospital, Boston, Massachusetts, USA.</aff><aff id="A32"><label>32</label>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.</aff><aff id="A33"><label>33</label>Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA.</aff><aff id="A34"><label>34</label>Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.</aff><aff id="A35"><label>35</label>National Heart and Lung Institute, Imperial College London, London, UK.</aff><aff id="A36"><label>36</label>Merck Research Laboratories, Merck & Co., Inc., Boston, Massachusetts, USA.</aff><aff id="A37"><label>37</label>Pacific Biosciences, Menlo Park, California, USA.</aff><aff id="A38"><label>38</label>Sage Bionetworks, Seattle, Washington, USA.</aff><aff id="A39"><label>39</label>Genetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics, Oxford, UK.</aff><aff id="A40"><label>40</label>Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA.</aff><aff id="A41"><label>41</label>Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.</aff><aff id="A42"><label>42</label>On behalf of the MAGIC (Meta-Analyses of Glucose and Insulin-related traits Consortium) investigators.</aff><aff id="A43"><label>43</label>Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</aff><aff id="A44"><label>44</label>University of Melbourne, Parkville, Australia.</aff><aff id="A45"><label>45</label>Department of Primary Industries, Melbourne, Victoria, Australia.</aff><aff id="A46"><label>46</label>Montreal Heart Institute, Montreal, Quebec, Canada.</aff><aff id="A47"><label>47</label>Department of Medicine, Université de Montréal, Montreal, Quebec, Canada.</aff><aff id="A48"><label>48</label>Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK.</aff><aff id="A49"><label>49</label>Neurogenetics Laboratory, Queensland Institute of Medical Research, Queensland, Australia.</aff><aff id="A50"><label>50</label>Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.</aff><aff id="A51"><label>51</label>The Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA.</aff><aff id="A52"><label>52</label>Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.</aff><aff id="A53"><label>53</label>Icelandic Heart Association, Kopavogur, Iceland.</aff><aff id="A54"><label>54</label>University of Iceland, Reykjavik, Iceland.</aff><aff id="A55"><label>55</label>Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, Queensland, Australia.</aff><aff id="A56"><label>56</label>Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.</aff><aff id="A57"><label>57</label>Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.</aff><aff id="A58"><label>58</label>Hudson Alpha Institute for Biotechnology, Huntsville, Alabama, USA.</aff><aff id="A59"><label>59</label>Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, UK.</aff><aff id="A60"><label>60</label>Department of Medicine, University of Washington, Seattle, Washington, USA.</aff><aff id="A61"><label>61</label>Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA.</aff><aff id="A62"><label>62</label>MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, UK.</aff><aff id="A63"><label>63</label>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.</aff><aff id="A64"><label>64</label>Department of Biological Psychology, Vrije Universiteit (VU) University Amsterdam, Amsterdam, The Netherlands.</aff><aff id="A65"><label>65</label>Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, Uppsala, Sweden.</aff><aff id="A66"><label>66</label>Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.</aff><aff id="A67"><label>67</label>Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, UK.</aff><aff id="A68"><label>68</label>Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London UK.</aff><aff id="A69"><label>69</label>Institute of Health Sciences, University of Oulu, Oulu, Finland.</aff><aff id="A70"><label>70</label>Biocenter Oulu, University of Oulu, Oulu, Finland.</aff><aff id="A71"><label>71</label>Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.</aff><aff id="A72"><label>72</label>Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria.</aff><aff id="A73"><label>73</label>Department of Biostatistics, University of Washington, Seattle, Washington, USA.</aff><aff id="A74"><label>74</label>Andrija Stampar School of Public Health, Medical School, University of Zagreb, Zagreb, Croatia.</aff><aff id="A75"><label>75</label>Gen-Info Ltd, Zagreb, Croatia.</aff><aff id="A76"><label>76</label>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.</aff><aff id="A77"><label>77</label>Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</aff><aff id="A78"><label>78</label>National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, Helsinki, Finland.</aff><aff id="A79"><label>79</label>Istituto di Neurogenetica e Neurofarmacologia del CNR, Monserrato, Cagliari, Italy.</aff><aff id="A80"><label>80</label>Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.</aff><aff id="A81"><label>81</label>National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.</aff><aff id="A82"><label>82</label>Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.</aff><aff id="A83"><label>83</label>Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.</aff><aff id="A84"><label>84</label>Hagedorn Research Institute, Gentofte, Denmark.</aff><aff id="A85"><label>85</label>Regensburg University Medical Center, Clinic and Policlinic for Internal Medicine II, Regensburg, Germany.</aff><aff id="A86"><label>86</label>MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, Oakfield House, Bristol, UK.</aff><aff id="A87"><label>87</label>Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.</aff><aff id="A88"><label>88</label>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.</aff><aff id="A89"><label>89</label>Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA.</aff><aff id="A90"><label>90</label>Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Crawley, Western Australia, Australia.</aff><aff id="A91"><label>91</label>Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.</aff><aff id="A92"><label>92</label>Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.</aff><aff id="A93"><label>93</label>Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Malmö, Sweden.</aff><aff id="A94"><label>94</label>Zentrum für Zahn-, Mund- und Kieferheilkunde, Greifswald, Germany.</aff><aff id="A95"><label>95</label>Department of Medicine III, University of Dresden, Dresden, Germany.</aff><aff id="A96"><label>96</label>Division of Endocrinology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.</aff><aff id="A97"><label>97</label>Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, UK.</aff><aff id="A98"><label>98</label>Department of Internal Medicine B, Ernst-Moritz-Arndt University, Greifswald, Germany.</aff><aff id="A99"><label>99</label>MRC-Health Protection Agency (HPA) Centre for Environment and Health, London, UK.</aff><aff id="A100"><label>100</label>Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland.</aff><aff id="A101"><label>101</label>National Institute for Health and Welfare, Helsinki, Finland.</aff><aff id="A102"><label>102</label>Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland.</aff><aff id="A103"><label>103</label>Folkhalsan Research Centre, Helsinki, Finland.</aff><aff id="A104"><label>104</label>Vasa Central Hospital, Vasa, Finland.</aff><aff id="A105"><label>105</label>Center for Neurobehavioral Genetics, University of California, Los Angeles, California, USA.</aff><aff id="A106"><label>106</label>Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.</aff><aff id="A107"><label>107</label>Department of Medicine III, Pathobiochemistry, University of Dresden, Dresden, Germany.</aff><aff id="A108"><label>108</label>Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, Oulu, Finland.</aff><aff id="A109"><label>109</label>National Institute for Health and Welfare, Department of Chronic Disease Prevention, Chronic Disease Epidemiology and Prevention Unit, Helsinki, Finland.</aff><aff id="A110"><label>110</label>Institute of Biomedicine, Department of Physiology, University of Oulu, Oulu, Finland.</aff><aff id="A111"><label>111</label>Department of Psychiatry, Kuopio University Hospital and University of Kuopio, Kuopio, Finland.</aff><aff id="A112"><label>112</label>Institute of Genetic Medicine, European Academy Bozen-Bolzano (EURAC), Bolzano-Bozen, Italy (affiliated Institute of the University of Lübeck, Lübeck, Germany).</aff><aff id="A113"><label>113</label>PathWest Laboratory of Western Australia, Department of Molecular Genetics, J Block, QEII Medical Centre, Nedlands, Western Australia, Australia.</aff><aff id="A114"><label>114</label>Busselton Population Medical Research Foundation Inc., Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.</aff><aff id="A115"><label>115</label>National Institute for Health and Welfare, Department of Chronic Disease Prevention, Population Studies Unit, Turku, Finland.</aff><aff id="A116"><label>116</label>Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.</aff><aff id="A117"><label>117</label>National Institute for Health and Welfare, Diabetes Prevention Unit, Helsinki, Finland.</aff><aff id="A118"><label>118</label>Interdisciplinary Centre for Clinical Research, University of Leipzig, Leipzig, Germany.</aff><aff id="A119"><label>119</label>Institut für Pharmakologie, Universität Greifswald, Greifswald, Germany.</aff><aff id="A120"><label>120</label>Croatian Centre for Global Health, School of Medicine, University of Split, Split, Croatia.</aff><aff id="A121"><label>121</label>Department of Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland.</aff><aff id="A122"><label>122</label>Nord-Trøndelag Health Study (HUNT) Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.</aff><aff id="A123"><label>123</label>Finnish Institute of Occupational Health, Oulu, Finland.</aff><aff id="A124"><label>124</label>Institut inter-regional pour la sante (IRSA), La Riche, France.</aff><aff id="A125"><label>125</label>Centre National de Genotypage, Evry, Paris, France.</aff><aff id="A126"><label>126</label>Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland.</aff><aff id="A127"><label>127</label>Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK.</aff><aff id="A128"><label>128</label>Avon Longitudinal Study of Parents and Children (ALSPAC) Laboratory, Department of Social Medicine, University of Bristol, Bristol, UK.</aff><aff id="A129"><label>129</label>Division of Health, Research Board, An Bord Taighde Sláinte, Dublin, Ireland.</aff><aff id="A130"><label>130</label>Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.</aff><aff id="A131"><label>131</label>Amgen, Cambridge, Massachusetts, USA.</aff><aff id="A132"><label>132</label>Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK.</aff><aff id="A133"><label>133</label>Finnish Twin Cohort Study, Department of Public Health, University of Helsinki, Helsinki, Finland.</aff><aff id="A134"><label>134</label>Obesity Research Unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland.</aff><aff id="A135"><label>135</label>Department of Medicine, Levanger Hospital, The Nord-Trøndelag Health Trust, Levanger, Norway.</aff><aff id="A136"><label>136</label>National Institute for Health and Welfare, Oulu, Finland.</aff><aff id="A137"><label>137</label>Department of Clinical Sciences, Lund University, Malmö, Sweden.</aff><aff id="A138"><label>138</label>Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK.</aff><aff id="A139"><label>139</label>Leicester National Institute for Health Research (NIHR) Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, UK.</aff><aff id="A140"><label>140</label>South Karelia Central Hospital, Lappeenranta, Finland.</aff><aff id="A141"><label>141</label>Division of Cardiology, Cardiovascular Laboratory, Helsinki University Central Hospital, Helsinki, Finland.</aff><aff id="A142"><label>142</label>Department of Psychiatry/Instituut voor Extramuraal Geneeskundig Onderzoek (EMGO) Institute, VU University Medical Center, Amsterdam, The Netherlands.</aff><aff id="A143"><label>143</label>Atherosclerosis Research Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.</aff><aff id="A144"><label>144</label>Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.</aff><aff id="A145"><label>145</label>Center of Medical Systems Biology, Leiden University Medical Center, Leiden, The Netherlands.</aff><aff id="A146"><label>146</label>Institut für Klinische Chemie und Laboratoriumsmedizin, Universität Greifswald, Greifswald, Germany.</aff><aff id="A147"><label>147</label>Steno Diabetes Center, Gentofte, Denmark.</aff><aff id="A148"><label>148</label>Department of Physiatrics, Lapland Central Hospital, Rovaniemi, Finland.</aff><aff id="A149"><label>149</label>School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Western Australia, Australia.</aff><aff id="A150"><label>150</label>School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia.</aff><aff id="A151"><label>151</label>Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland.</aff><aff id="A152"><label>152</label>Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Tampere, Finland.</aff><aff id="A153"><label>153</label>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.</aff><aff id="A154"><label>154</label>The Department of Clinical Physiology, Turku University Hospital, Turku, Finland.</aff><aff id="A155"><label>155</label>Department of Medicine, University of Leipzig, Leipzig, Germany.</aff><aff id="A156"><label>156</label>Leipziger Interdisziplinärer Forschungskomplex zu molekularen Ursachen umwelt- und lebensstilassoziierter Erkrankungen (LIFE) Study Centre, University of Leipzig, Leipzig, Germany.</aff><aff id="A157"><label>157</label>Coordination Centre for Clinical Trials, University of Leipzig, Leipzig, Germany.</aff><aff id="A158"><label>158</label>Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland.</aff><aff id="A159"><label>159</label>INSERM Centre de Recherche en Epidémiologie et Santé des Populations (CESP) U1018, Villejuif, France.</aff><aff id="A160"><label>160</label>University Paris Sud 11, Unité Mixte de Recherche en Santé (UMRS) 1018, Villejuif, France.</aff><aff id="A161"><label>161</label>Department of Social Medicine, University of Bristol, Bristol, UK.</aff><aff id="A162"><label>162</label>The London School of Hygiene and Tropical Medicine, London, UK.</aff><aff id="A163"><label>163</label>South Asia Network for Chronic Disease, New Delhi, India.</aff><aff id="A164"><label>164</label>Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK.</aff><aff id="A165"><label>165</label>Faculty of Health Science, University of Southern Denmark, Odense, Denmark.</aff><aff id="A166"><label>166</label>Klinik und Poliklinik für Innere Medizin II, Universität Regensburg, Regensburg, Germany.</aff><aff id="A167"><label>167</label>Regensburg University Medical Center, Innere Medizin II, Regensburg, Germany.</aff><aff id="A168"><label>168</label>Department of Social Services and Health Care, Jakobstad, Finland.</aff><aff id="A169"><label>169</label>Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark.</aff><aff id="A170"><label>170</label>Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.</aff><aff id="A171"><label>171</label>NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK.</aff><aff id="A172"><label>172</label>Department of Endocrinology, Diabetology and Nutrition, Bichat-Claude Bernard University Hospital, Assistance Publique des Hôpitaux de Paris, Paris, France.</aff><aff id="A173"><label>173</label>Cardiovascular Genetics Research Unit, Université Henri Poincaré-Nancy 1, Nancy, France.</aff><aff id="A174"><label>174</label>Institute of Human Genetics, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany.</aff><aff id="A175"><label>175</label>Institute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.</aff><aff id="A176"><label>176</label>Institute of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.</aff><aff id="A177"><label>177</label>Faculty of Health Science, University of Aarhus, Aarhus, Denmark.</aff><aff id="A178"><label>178</label>Department of Medicine III, Prevention and Care of Diabetes, University of Dresden, Dresden, Germany.</aff><aff id="A179"><label>179</label>Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland.</aff><aff id="A180"><label>180</label>Research Program of Molecular Medicine, University of Helsinki, Helsinki, Finland.</aff><aff id="A181"><label>181</label>Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki, Finland.</aff><aff id="A182"><label>182</label>South Ostrobothnia Central Hospital, Seinajoki, Finland.</aff><aff id="A183"><label>183</label>Collaborative Health Studies Coordinating Center, Seattle, Washington, USA.</aff><aff id="A184"><label>184</label>Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, Lausanne, Switzerland.</aff><aff id="A185"><label>185</label>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas, USA.</aff><aff id="A186"><label>186</label>Division of Research, Kaiser Permanente Northern California, Oakland, California, USA.</aff><aff id="A187"><label>187</label>Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.</aff><aff id="A188"><label>188</label>Department of Epidemiology and Medicine, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.</aff><aff id="A189"><label>189</label>National Institute for Health and Welfare, Department of Mental Health and Substance Abuse Services, Unit for Child and Adolescent Mental Health, Helsinki, Finland.</aff><aff id="A190"><label>190</label>Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands.</aff><aff id="A191"><label>191</label>Department of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands.</aff><aff id="A192"><label>192</label>Department of Psychiatry, University Medical Centre Groningen, Groningen, The Netherlands.</aff><aff id="A193"><label>193</label>Department of Neurology, General Central Hospital, Bolzano, Italy.</aff><aff id="A194"><label>194</label>Department of Neurology, University of Lübeck, Lübeck, Germany.</aff><aff id="A195"><label>195</label>Departments of Epidemiology, Medicine and Health Services, University of Washington, Seattle, Washington, USA.</aff><aff id="A196"><label>196</label>Group Health Research Institute, Group Health, Seattle, Washington, USA.</aff><aff id="A197"><label>197</label>Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, Maryland, USA.</aff><aff id="A198"><label>198</label>Uppsala University, Department of Medical Sciences, Molecular Medicine, Uppsala, Sweden.</aff><aff id="A199"><label>199</label>Institut für Community Medicine, Greifswald, Germany.</aff><aff id="A200"><label>200</label>Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, Lausanne, Switzerland.</aff><aff id="A201"><label>201</label>Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA.</aff><aff id="A202"><label>202</label>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.</aff><aff id="A203"><label>203</label>Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.</aff><aff id="A204"><label>204</label>Carolina Center for Genome Sciences, School of Public Health, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA.</aff><aff id="A205"><label>205</label>Department of Medical Genetics, University of Helsinki, Helsinki, Finland.</aff><aff id="A206"><label>206</label>Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, USA.</aff><aff id="A207"><label>207</label>Division of Community Health Sciences, St George’s, University of London, London, UK.</aff><aff id="A208"><label>208</label>Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.</aff><aff id="A209"><label>209</label>Klinikum Grosshadern, Munich, Germany.</aff><aff id="A210"><label>210</label>Ludwig-Maximilians-Universität, Institute of Medical Informatics, Biometry and Epidemiology, Munich, Germany.</aff><aff id="A211"><label>211</label>Faculty of Medicine, University of Iceland, Reykjavík, Iceland.</aff><aff id="A212"><label>212</label>University of Cambridge Metabolic Research Labs, Institute of Metabolic Science Addenbrooke’s Hospital, Cambridge, UK.</aff><aff id="A213"><label>213</label>Division of Intramural Research, National Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, Massachusetts, USA.</aff><author-notes><corresp id="CR1">Correspondence should be addressed to C.M.L. (<email>celi@well.ox.ac.uk</email>), K.L.M. (<email>mohlke@med.unc.edu</email>), C.S.F. (<email>foxca@nhlbi.nih.gov</email>), M.I.M. (<email>mark.mccarthy@drl.ox.ac.uk</email>) or I.M.H. (<email>iris.heid@klinik.uni-regensburg.de</email>).</corresp><fn fn-type="equal" id="FN1"><label>214</label><p id="P1">These authors contributed equally to this work.</p></fn><fn id="FN2"><label>215</label><p id="P2">These authors jointly directed this work.</p></fn><fn id="FN3"><p id="P3"><bold>AUTHOR CONTRIBUTIONS Writing group:</bold> I.B., C.S.F., I.M.H. (lead), C.M.L. (lead), M.I.M., K.L. Mohlke, L.Q., V. Steinthorsdottir, G.T., M.C.Z.</p><p id="P4"><bold>Waist phenotype working group:</bold> T.L.A., N.B., I.B., L.A.C., C.M.D., C.S.F., T.B.H., I.M.H., A.U.J., C.M.L. (lead), R.J.F.L., R.M., M.I.M., K.L. Mohlke, L.Q., J.C.R., E.K.S., V. Steinthorsdottir, K. Stefansson, G.T., U.T., C.C.W., T.W., T.W.W., H.E.W., M.C.Z.</p><p id="P5"><bold>Data cleaning and analysis:</bold> S.I.B., I.M.H. (lead), E.I., A.U.J., H.L., C.M.L. (lead), R.J.F.L. (lead), J.L., R.M., L.Q., J.C.R., E.K.S., G.T., S.V., M.N.W., E.W., C.J.W., T.W.W., T.W.</p><p id="P6"><bold>Sex-specific analyses:</bold> S.I.B., T.E., I.M.H., A.U.J., T.O.K., Z.K., S.L., C.M.L., R.J.F.L., R.M., K.L. Monda, K.E.N., L.Q., J.C.R. (lead), V. Steinthorsdottir, G.T., T.W.W. (lead).</p><p id="P7"><bold>eQTL and expression analyses:</bold> S.I.B., A.L.D., C.C.H., J.N.H., F.K., L.M.K., C.M.L., L.L., R.J.F.L., J.L., M.F.M., J.L.M., C.M., G.N., E.E.S., E.K.S., V. Steinthorsdottir, G.T., K.T.Z.</p><p id="P8"><bold>Pathway and CNV analyses</bold>: C.M.L., S.A.M., M.I.M., J.N., V. Steinthorsdottir, G.T., B.F.V.</p><p id="P9"><bold>Secondary analyses:</bold> S.I.B., I.B.B., N.C., K.E., T.M.F., M.F.F., T.F., M.E.G., J.N.H., E.I., G.L., C.M.L., H.L., R.M., M. Mangino, M.I.M., K.L. Mohlke, D.R.N., J.R.O., S.P., J.R.B.P., J.C.R., A.V.S., E.K.S., P.M.V., M.N.W., C.J.W., R.J.W., E.W., A.R.W., J.Y.</p><p id="P10"><bold>Study-specific analyses:</bold> G.R.A., D.A., N.A., T.A., T.L.A., N.B., C.C., P.S.C., L.C., L.A.C., D.I.C., M.N.C., C.M.D., T.E., K.E., E.F., M.F.F., T.F., A.P.G., N.L.G., M.E.G., C. Hayward, N.L.H., I.M.H., J.J.H., A.U.J., Å.J., T. Johnson, J.O.J., J.R.K., M. Kaakinen, K. Kapur, S. Ketkar, J.W.K., P. Kraft, A.T.K., Z.K., J. Kettunen, C. Lamina, R.J.F.L., C. Lecoeur, H.L., M.F.L., C.M.L., J.L., R.W.L., R.M., M. Mangino, B.M., K.L. Monda, A.P.M., N.N., K.E.N., D.R.N., J.R.O., K.K.O., C.O., M.J.P., O. Polasek, I. Prokopenko, N.P., M.P., L.Q., J.C.R., N.W.R., S.R., F.R., N.R.R., C.S., L.J.S., K. Silander, E.K.S., K. Stark, S.S., A.V.S., N.S., U.S., V. Steinthorsdottir, D.P.S., I.S., M.L.T., T.M.T., N.J.T., A.T., G.T., A.U., S.V., V. Vitart, L.V., P.M.V., R.M.W., R.W., R.J.W., S.W., M.N.W., C.C.W., C.J.W., T.W.W., A.R.W., J.Y., J.H.Z., M.C.Z.</p><p id="P11"><bold>Study-specific genotyping:</bold> D.A., T.L.A., L.D.A., N.B., I.B., A.J.B., E.B., L.L.B., I.B.B., H.C., D.I.C., I.N.M.D., M. Dei, M.R.E., P.E., K.E., N.B.F., M.F., A.P.G., H.G., C.G., E.J.C.G., C.J.G., T. Hansen, A.L.H., N.H., C. Hayward, A.A.H., J.J.H., F.B.H., D.J.H., J.H., W.I., M.R.J., Å.J., J.O.J., J.W.K., P. Kovacs, A.T.K., H.K.K., J. Kettunen, P. Kraft, R.N.L., C.M.L., R.J.F.L., J.L., M.L.L., M.A.M., M. Mangino, W.L.M., M.I.M., J.B.J.M., M.J.N., M.N., D.R.N., K.K.O., C.O., O. Pedersen, L.P., M.J.P., G.P., A.N.P., N.P., L.Q., N.W.R., F.R., N.R.R., C.S., A.J.S., N.S., A.C.S., M.T., B.T., A.U., G.U., V. Vatin, P.M.V., H.W., P.Z.</p><p id="P12"><bold>Study-specific phenotyping:</bold> H.A., P.A., D.A., A.M.A., T.L.A., B.B., S.R.B., R.B., E.B., I.B.B., J.P.B., M. Dörr, C.M.D., P.E., M.F.F., C.S.F., T.M.F., M.F., S.G., J.G., L.C.G., T. Hansen, A.S.H., C. Hengstenberg, A.L.H., A.T.H., K.H.H., A. Hofman, F.B.H., D.J.H., B.I., T.I., T. Jørgensen, P.J., M.R.J., Å.J., A.J., A.L.J., J.O.J., F.K., L.K., J. Kuusisto, K. Kvaloy, R.K., S. Ketkar, J.W.K., I.K., S. Koskinen, V.K., M. Kähönen, P. Kovacs, O.L., R.N.L., B.L., J.L., G.M.L., R.J.F.L., T.L., M. Mangino, M.I.M., C.O., B.M.P., O. Pedersen, C.G.P.P., J.F.P., I. Pichler, K.P., O. Polasek, A.P., L.Q., M.R., I.R., O.R., V. Salomaa, J. Saramies, P.E.H.S., K. Silander, N.J.S., J.H.S., T.D.S., D.P.S., R.S., H.M.S., J. Sinisalo, T.T., A.T., M.U., P.V., C.B.V., L.V., J.V., D.R.W., G.B.W., S.H.W., G.W., J.C.W., A.F.W., L.Z., P.Z.</p><p id="P13"><bold>Study-specific management:</bold> G.R.A., A.M.A., B.B., Y.B.S., R.N.B., H.B., J.S.B., S.B., M.B., E.B., D.I.B., I.B.B., J.P.B., M.J.C., F.S.C., L.A.C., G.D., C.M.D., S.E., G.E., P.F., C.S.F., T.M.F., L.C.G., V.G., U.G., M.E.G., T. Hansen, C. Hengstenberg, K.H., A. Hamsten, T.B.H., A.T.H., A. Hofman, F.B.H., D.J.H., B.I., T.I., C.I., T. Jørgensen, M.R.J., A.L.J., F.K., K.T.K., W.H.L.K., R.K., J. Kaprio, M. Kähönen, M.L., D.A.L., L.J.L., C.M.L., R.J.F.L., T.L., M. Marre, T.M., A.M.E.T., K.M., M.I.M., K.L. Mohlke, P.B.M., K.E.N., M.S.N., D.R.N., B.O., C.O., O. Pedersen, L.P., B.W.P., P.P.P., B.M.P., L.J.P., T.Q., A.R., I.R., O.R., P.M.R., V. Salomaa, P.S., D.S., A.R.S., N.S., T.D.S., K. Stefansson, D.P.S., A.C.S., M.S., T.T., J.T., U.T., A.T., M.U., A.U., T.T.V., P.V., H.V., J.V., P.M.V., N.J.W., H.E.W., J.F.W., J.C.W., A.F.W.</p><p id="P14"><bold>Steering committee:</bold> G.R.A., T.L.A., I.B., S.I.B., M.B., I.B.B., P.D., C.M.D., C.S.F., T.M.F., L.C.G., T. Haritunians, J.N.H. (chair), D.J.H., E.I., R.K., R.J.F.L., M.I.M., K.L. Mohlke, K.E.N., J.R.O., L.P., D.S., D.P.S., U.T., H.E.W.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>12</day><month>4</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>10</day><month>10</month><year>2010</year></pub-date><pub-date pub-type="ppub"><month>11</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>5</month><year>2011</year></pub-date><volume>42</volume><issue>11</issue><fpage>949</fpage><lpage>960</lpage><permissions><copyright-statement>© 2010 Nature America, Inc. All rights reserved.</copyright-statement><copyright-year>2010</copyright-year></permissions><abstract><p id="P15">Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near <italic>RSPO3</italic>, <italic>VEGFA</italic>, <italic>TBX15-WARS2</italic>, <italic>NFE2L3</italic>, <italic>GRB14</italic>, <italic>DNM3-PIGC</italic>, <italic>ITPR2-SSPN</italic>, <italic>LY86</italic>, <italic>HOXC13</italic>, <italic>ADAMTS9</italic>, <italic>ZNRF3-KREMEN1</italic>, <italic>NISCH-STAB1</italic> and <italic>CPEB4</italic> (<italic>P</italic> = 1.9 × 10<sup>−9</sup> to <italic>P</italic> = 1.8 × 10<sup>−40</sup>) and the known signal at <italic>LYPLAL1</italic>. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (<italic>P</italic> for sex difference = 1.9 × 10<sup>−3</sup> to <italic>P</italic> = 1.2 × 10<sup>−13</sup>). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.</p></abstract><funding-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>091746 || WT</award-id></award-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>089061 || WT</award-id></award-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>088885 || WT</award-id></award-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>086596 || WT</award-id></award-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>085301 || WT</award-id></award-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>085235 || WT</award-id></award-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>083270 || WT</award-id></award-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>081682 || WT</award-id></award-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>079895 || WT</award-id></award-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>079557 || WT</award-id></award-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>079557 || WT</award-id></award-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>077016 || WT</award-id></award-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>077011 || WT</award-id></award-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>076113 || WT</award-id></award-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>076113 || WT</award-id></award-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>076113 || WT</award-id></award-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>076113 || WT</award-id></award-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>076113 || WT</award-id></award-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>076113 || WT</award-id></award-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>072960 || WT</award-id></award-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>068545 || WT</award-id></award-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>068545 || WT</award-id></award-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>064890 || WT</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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