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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Association Between BRCA1 and BRCA2 Mutations and Survival in Women with Invasive Epithelial Ovarian Cancer</title>
<author><name sortKey="Bolton, Kelly L" sort="Bolton, Kelly L" uniqKey="Bolton K" first="Kelly L." last="Bolton">Kelly L. Bolton</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda MD 20892, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">David Geffen School of Medicine at the University of California, Los Angeles CA 90095, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
<affiliation><nlm:aff id="A3">Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Herston, QLD 4029, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Goh, Cindy" sort="Goh, Cindy" uniqKey="Goh C" first="Cindy" last="Goh">Cindy Goh</name>
<affiliation><nlm:aff id="A4">Addenbrooke’s Hospital, Hills Road, Cambridge CB2 OQQ, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sadetzki, Siegal" sort="Sadetzki, Siegal" uniqKey="Sadetzki S" first="Siegal" last="Sadetzki">Siegal Sadetzki</name>
<affiliation><nlm:aff id="A5">Cancer and Radiation Epidemiology Unit, Gertner Institute for Epidemiology and Health Policy, Sheba Medical Center, Tel Hashomer, 52621, Israel</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A6">Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, 69978 Israel</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ramus, Susan J" sort="Ramus, Susan J" uniqKey="Ramus S" first="Susan J." last="Ramus">Susan J. Ramus</name>
<affiliation><nlm:aff id="A7">Department of Preventive Medicine, Keck School of Medicine University of Southern California, Los Angeles, California, 90033, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Karlan, Beth Y" sort="Karlan, Beth Y" uniqKey="Karlan B" first="Beth Y." last="Karlan">Beth Y. Karlan</name>
<affiliation><nlm:aff id="A8">Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048 USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name>
<affiliation><nlm:aff id="A9">VIB Vesalius Research Center, University of Leuven, Leuven, 3000 Belgium</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Despierre, Evelyn" sort="Despierre, Evelyn" uniqKey="Despierre E" first="Evelyn" last="Despierre">Evelyn Despierre</name>
<affiliation><nlm:aff id="A10">Division of Gynaecologic Oncology, Department of Obstetrics and Gynaecology, University Hospitals Leuven, University of Leuven, Leuven, 3000 Belgium</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Barrowdale, Daniel" sort="Barrowdale, Daniel" uniqKey="Barrowdale D" first="Daniel" last="Barrowdale">Daniel Barrowdale</name>
<affiliation><nlm:aff id="A11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name>
<affiliation><nlm:aff id="A11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name>
<affiliation><nlm:aff id="A3">Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Herston, QLD 4029, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name>
<affiliation><nlm:aff id="A11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sinilnikova, Olga" sort="Sinilnikova, Olga" uniqKey="Sinilnikova O" first="Olga" last="Sinilnikova">Olga Sinilnikova</name>
<affiliation><nlm:aff id="A12">Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon, Lyon 69373, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A13">Centre Léon Bérard, and Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon 69373, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name>
<affiliation><nlm:aff id="A14">Human Cancer Genetics Programme and Genotyping Unit, Spanish National Cancer Research Centre, Melchor Fernández Almagro 3, Madrid 28029, Spain</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A15">CIBERER, Melchor Fernández Almagro 3, Madrid 28029, Spain</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Garcia, Maria J" sort="Garcia, Maria J" uniqKey="Garcia M" first="María J." last="García">María J. García</name>
<affiliation><nlm:aff id="A15">CIBERER, Melchor Fernández Almagro 3, Madrid 28029, Spain</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A16">Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Melchor Fernández Almagro 3, Madrid 28029, Spain</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Neuhausen, Susan" sort="Neuhausen, Susan" uniqKey="Neuhausen S" first="Susan" last="Neuhausen">Susan Neuhausen</name>
<affiliation><nlm:aff id="A17">Department of Population Sciences, the Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gail, Mitchell H" sort="Gail, Mitchell H" uniqKey="Gail M" first="Mitchell H." last="Gail">Mitchell H. Gail</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda MD 20892, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hartge, Patricia" sort="Hartge, Patricia" uniqKey="Hartge P" first="Patricia" last="Hartge">Patricia Hartge</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda MD 20892, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Peock, Susan" sort="Peock, Susan" uniqKey="Peock S" first="Susan" last="Peock">Susan Peock</name>
<affiliation><nlm:aff id="A11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Frost, Debra" sort="Frost, Debra" uniqKey="Frost D" first="Debra" last="Frost">Debra Frost</name>
<affiliation><nlm:aff id="A11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Evans, D Gareth" sort="Evans, D Gareth" uniqKey="Evans D" first="D. Gareth" last="Evans">D. Gareth Evans</name>
<affiliation><nlm:aff id="A18">Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, M13 9WL UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Eeles, Ros" sort="Eeles, Ros" uniqKey="Eeles R" first="Ros" last="Eeles">Ros Eeles</name>
<affiliation><nlm:aff id="A19">Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, SM2 5NG UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K." last="Godwin">Andrew K. Godwin</name>
<affiliation><nlm:aff id="A20">Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, Kansas City, KS 66160, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B." last="Daly">Mary B. Daly</name>
<affiliation><nlm:aff id="A21">Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA 19111, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kwong, Ava" sort="Kwong, Ava" uniqKey="Kwong A" first="Ava" last="Kwong">Ava Kwong</name>
<affiliation><nlm:aff id="A22">The Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Centre, Hong Kong Sanatorium and Hospital, 4/F, Central Block, 2 Village Road, Hong Kong</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A23">Division of Breast Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ma, Edmond Sk" sort="Ma, Edmond Sk" uniqKey="Ma E" first="Edmond Sk" last="Ma">Edmond Sk Ma</name>
<affiliation><nlm:aff id="A22">The Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Centre, Hong Kong Sanatorium and Hospital, 4/F, Central Block, 2 Village Road, Hong Kong</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A24">Division of Molecular Pathology, Hong Kong Sanatorium and Hospital, 4/F, Central Block, 2 Village Road, Hong Kong</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lazaro, Conxi" sort="Lazaro, Conxi" uniqKey="Lazaro C" first="Conxi" last="Lázaro">Conxi Lázaro</name>
<affiliation><nlm:aff id="A25">Hereditary Cancer Programme, Catalan Institute of Oncology, IDIBELL, Gran Via 199-203, L’Hospitalet, Barcelona 08907, Spain</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Blanco, Ignacio" sort="Blanco, Ignacio" uniqKey="Blanco I" first="Ignacio" last="Blanco">Ignacio Blanco</name>
<affiliation><nlm:aff id="A25">Hereditary Cancer Programme, Catalan Institute of Oncology, IDIBELL, Gran Via 199-203, L’Hospitalet, Barcelona 08907, Spain</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name>
<affiliation><nlm:aff id="A26">Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto - IRCCS, Via Gattamelata 64, 35128 Padua, Italy</nlm:aff>
</affiliation>
</author>
<author><name sortKey="D Ndrea, Emma" sort="D Ndrea, Emma" uniqKey="D Ndrea E" first="Emma" last="D Ndrea">Emma D Ndrea</name>
<affiliation><nlm:aff id="A27">Department of Oncology and Surgical Sciences, University of Padua, 35128 Padua, Italy</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A28">Istituto Oncologico Veneto IRCCS, Via Gattamelata 64, 35128 Padua, Italy</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nicoletto, Ornella" sort="Nicoletto, Ornella" uniqKey="Nicoletto O" first="Ornella" last="Nicoletto">Ornella Nicoletto</name>
<affiliation><nlm:aff id="A29">Medical Oncology Unit, Istituto Oncologico Veneto - IRCCS, Via Gattamelata 64, 35128 Padua, Italy</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Investigators, Kconfab" sort="Investigators, Kconfab" uniqKey="Investigators K" first="Kconfab" last="Investigators">Kconfab Investigators</name>
<affiliation><nlm:aff id="A30">Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Johnatty, Sharon E" sort="Johnatty, Sharon E" uniqKey="Johnatty S" first="Sharon E." last="Johnatty">Sharon E. Johnatty</name>
<affiliation><nlm:aff id="A3">Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Herston, QLD 4029, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kj R, Susanne Kruger" sort="Kj R, Susanne Kruger" uniqKey="Kj R S" first="Susanne Krüger" last="Kj R">Susanne Krüger Kj R</name>
<affiliation><nlm:aff id="A31">Department of Virus, Hormones and Cancer, Danish Cancer Society, Copenhagen, 2100 Denmark</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A32">Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, 2100 Denmark</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jensen, Allan" sort="Jensen, Allan" uniqKey="Jensen A" first="Allan" last="Jensen">Allan Jensen</name>
<affiliation><nlm:aff id="A31">Department of Virus, Hormones and Cancer, Danish Cancer Society, Copenhagen, 2100 Denmark</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A32">Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, 2100 Denmark</nlm:aff>
</affiliation>
</author>
<author><name sortKey="H Gdall, Estrid" sort="H Gdall, Estrid" uniqKey="H Gdall E" first="Estrid" last="H Gdall">Estrid H Gdall</name>
<affiliation><nlm:aff id="A31">Department of Virus, Hormones and Cancer, Danish Cancer Society, Copenhagen, 2100 Denmark</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A32">Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, 2100 Denmark</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Goode, Ellen L" sort="Goode, Ellen L" uniqKey="Goode E" first="Ellen L." last="Goode">Ellen L. Goode</name>
<affiliation><nlm:aff id="A33">Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fridley, Brooke L" sort="Fridley, Brooke L" uniqKey="Fridley B" first="Brooke L." last="Fridley">Brooke L. Fridley</name>
<affiliation><nlm:aff id="A33">Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Loud, Jennifer T" sort="Loud, Jennifer T" uniqKey="Loud J" first="Jennifer T." last="Loud">Jennifer T. Loud</name>
<affiliation><nlm:aff id="A34">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville MD 20852, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name>
<affiliation><nlm:aff id="A34">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville MD 20852, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L." last="Mai">Phuong L. Mai</name>
<affiliation><nlm:aff id="A34">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville MD 20852, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chetrit, Angela" sort="Chetrit, Angela" uniqKey="Chetrit A" first="Angela" last="Chetrit">Angela Chetrit</name>
<affiliation><nlm:aff id="A5">Cancer and Radiation Epidemiology Unit, Gertner Institute for Epidemiology and Health Policy, Sheba Medical Center, Tel Hashomer, 52621, Israel</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lubin, Flora" sort="Lubin, Flora" uniqKey="Lubin F" first="Flora" last="Lubin">Flora Lubin</name>
<affiliation><nlm:aff id="A35">Gertner Institute for Epidemiology and Health Policy, Sheba Medical Center, Tel Hashomer, 52621, Israel</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hirsh Yechezkel, Galit" sort="Hirsh Yechezkel, Galit" uniqKey="Hirsh Yechezkel G" first="Galit" last="Hirsh-Yechezkel">Galit Hirsh-Yechezkel</name>
<affiliation><nlm:aff id="A5">Cancer and Radiation Epidemiology Unit, Gertner Institute for Epidemiology and Health Policy, Sheba Medical Center, Tel Hashomer, 52621, Israel</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name>
<affiliation><nlm:aff id="A36">Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, M5G 2C1 Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name>
<affiliation><nlm:aff id="A36">Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, M5G 2C1 Canada</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A37">Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5 Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name>
<affiliation><nlm:aff id="A38">Division of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, The Comprehensive Cancer Center, The Ohio State University, Columbus, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Senter, Leigha" sort="Senter, Leigha" uniqKey="Senter L" first="Leigha" last="Senter">Leigha Senter</name>
<affiliation><nlm:aff id="A39">Clinical Cancer Genetics Program, Division of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, The Ohio State University, Columbus, 43210 USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gore, Martin E" sort="Gore, Martin E" uniqKey="Gore M" first="Martin E." last="Gore">Martin E. Gore</name>
<affiliation><nlm:aff id="A40">Gynecological Oncology Unit, The Royal Marsden Hospital, FulhamRoad, London SW3 6JJ, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gourley, Charlie" sort="Gourley, Charlie" uniqKey="Gourley C" first="Charlie" last="Gourley">Charlie Gourley</name>
<affiliation><nlm:aff id="A41">University of Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XR UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Michie, Caroline O" sort="Michie, Caroline O" uniqKey="Michie C" first="Caroline O" last="Michie">Caroline O. Michie</name>
<affiliation><nlm:aff id="A41">University of Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XR UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Song, Honglin" sort="Song, Honglin" uniqKey="Song H" first="Honglin" last="Song">Honglin Song</name>
<affiliation><nlm:aff id="A42">Cancer Research United Kingdom, Department of Oncology and Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tyrer, Jonathan" sort="Tyrer, Jonathan" uniqKey="Tyrer J" first="Jonathan" last="Tyrer">Jonathan Tyrer</name>
<affiliation><nlm:aff id="A42">Cancer Research United Kingdom, Department of Oncology and Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S." last="Whittemore">Alice S. Whittemore</name>
<affiliation><nlm:aff id="A43">Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mcguire, Valerie" sort="Mcguire, Valerie" uniqKey="Mcguire V" first="Valerie" last="Mcguire">Valerie Mcguire</name>
<affiliation><nlm:aff id="A43">Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sieh, Weiva" sort="Sieh, Weiva" uniqKey="Sieh W" first="Weiva" last="Sieh">Weiva Sieh</name>
<affiliation><nlm:aff id="A43">Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kristoffersson, Ulf" sort="Kristoffersson, Ulf" uniqKey="Kristoffersson U" first="Ulf" last="Kristoffersson">Ulf Kristoffersson</name>
<affiliation><nlm:aff id="A44">Department of Clinical Genetics, University and Regional Laboratories Skåne and Lund University, SE-20502 Lund, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Olsson, H Kan" sort="Olsson, H Kan" uniqKey="Olsson H" first="H Kan" last="Olsson">H Kan Olsson</name>
<affiliation><nlm:aff id="A45">Department of Oncology, Lund University, SE-22185 Lund, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Borg, Ke" sort="Borg, Ke" uniqKey="Borg " first=" Ke" last="Borg"> Ke Borg</name>
<affiliation><nlm:aff id="A45">Department of Oncology, Lund University, SE-22185 Lund, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Levine, Douglas A" sort="Levine, Douglas A" uniqKey="Levine D" first="Douglas A." last="Levine">Douglas A. Levine</name>
<affiliation><nlm:aff id="A46">Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065 USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Steele, Linda" sort="Steele, Linda" uniqKey="Steele L" first="Linda" last="Steele">Linda Steele</name>
<affiliation><nlm:aff id="A17">Department of Population Sciences, the Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Beattie, Mary S" sort="Beattie, Mary S" uniqKey="Beattie M" first="Mary S." last="Beattie">Mary S. Beattie</name>
<affiliation><nlm:aff id="A48">UCSF Cancer Risk Program, San Fransisco, CA 94143, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A49">UCSF Departments of Medicine, San Fransisco, CA 94118, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chan, Salina" sort="Chan, Salina" uniqKey="Chan S" first="Salina" last="Chan">Salina Chan</name>
<affiliation><nlm:aff id="A48">UCSF Cancer Risk Program, San Fransisco, CA 94143, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nussbaum, Robert" sort="Nussbaum, Robert" uniqKey="Nussbaum R" first="Robert" last="Nussbaum">Robert Nussbaum</name>
<affiliation><nlm:aff id="A48">UCSF Cancer Risk Program, San Fransisco, CA 94143, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A49">UCSF Departments of Medicine, San Fransisco, CA 94118, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Moysich, Kirsten B" sort="Moysich, Kirsten B" uniqKey="Moysich K" first="Kirsten B." last="Moysich">Kirsten B. Moysich</name>
<affiliation><nlm:aff id="A50">Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gross, Jenny" sort="Gross, Jenny" uniqKey="Gross J" first="Jenny" last="Gross">Jenny Gross</name>
<affiliation><nlm:aff id="A8">Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048 USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cass, Ilana" sort="Cass, Ilana" uniqKey="Cass I" first="Ilana" last="Cass">Ilana Cass</name>
<affiliation><nlm:aff id="A8">Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048 USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Walsh, Christine" sort="Walsh, Christine" uniqKey="Walsh C" first="Christine" last="Walsh">Christine Walsh</name>
<affiliation><nlm:aff id="A8">Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048 USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Li, Andrew J" sort="Li, Andrew J" uniqKey="Li A" first="Andrew J." last="Li">Andrew J. Li</name>
<affiliation><nlm:aff id="A8">Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048 USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Leuchter, Ronald" sort="Leuchter, Ronald" uniqKey="Leuchter R" first="Ronald" last="Leuchter">Ronald Leuchter</name>
<affiliation><nlm:aff id="A8">Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048 USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gordon, Ora" sort="Gordon, Ora" uniqKey="Gordon O" first="Ora" last="Gordon">Ora Gordon</name>
<affiliation><nlm:aff id="A8">Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048 USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name>
<affiliation><nlm:aff id="A51">Sections of Epidemiology and Genetics, Institute of Cancer Research and Breakthrough Breast Cancer Research Centre, London, SW7 3RP UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gayther, Simon A" sort="Gayther, Simon A" uniqKey="Gayther S" first="Simon A." last="Gayther">Simon A. Gayther</name>
<affiliation><nlm:aff id="A7">Department of Preventive Medicine, Keck School of Medicine University of Southern California, Los Angeles, California, 90033, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda MD 20892, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C." last="Antoniou">Antonis C. Antoniou</name>
<affiliation><nlm:aff id="A11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name>
<affiliation><nlm:aff id="A42">Cancer Research United Kingdom, Department of Oncology and Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">22274685</idno>
<idno type="pmc">3727895</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727895</idno>
<idno type="RBID">PMC:3727895</idno>
<idno type="doi">10.1001/jama.2012.20</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">001F38</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001F38</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Association Between BRCA1 and BRCA2 Mutations and Survival in Women with Invasive Epithelial Ovarian Cancer</title>
<author><name sortKey="Bolton, Kelly L" sort="Bolton, Kelly L" uniqKey="Bolton K" first="Kelly L." last="Bolton">Kelly L. Bolton</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda MD 20892, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">David Geffen School of Medicine at the University of California, Los Angeles CA 90095, USA</nlm:aff>
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<author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
<affiliation><nlm:aff id="A3">Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Herston, QLD 4029, Australia</nlm:aff>
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</author>
<author><name sortKey="Goh, Cindy" sort="Goh, Cindy" uniqKey="Goh C" first="Cindy" last="Goh">Cindy Goh</name>
<affiliation><nlm:aff id="A4">Addenbrooke’s Hospital, Hills Road, Cambridge CB2 OQQ, UK</nlm:aff>
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<author><name sortKey="Sadetzki, Siegal" sort="Sadetzki, Siegal" uniqKey="Sadetzki S" first="Siegal" last="Sadetzki">Siegal Sadetzki</name>
<affiliation><nlm:aff id="A5">Cancer and Radiation Epidemiology Unit, Gertner Institute for Epidemiology and Health Policy, Sheba Medical Center, Tel Hashomer, 52621, Israel</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A6">Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, 69978 Israel</nlm:aff>
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<author><name sortKey="Ramus, Susan J" sort="Ramus, Susan J" uniqKey="Ramus S" first="Susan J." last="Ramus">Susan J. Ramus</name>
<affiliation><nlm:aff id="A7">Department of Preventive Medicine, Keck School of Medicine University of Southern California, Los Angeles, California, 90033, USA</nlm:aff>
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</author>
<author><name sortKey="Karlan, Beth Y" sort="Karlan, Beth Y" uniqKey="Karlan B" first="Beth Y." last="Karlan">Beth Y. Karlan</name>
<affiliation><nlm:aff id="A8">Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048 USA</nlm:aff>
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<author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name>
<affiliation><nlm:aff id="A9">VIB Vesalius Research Center, University of Leuven, Leuven, 3000 Belgium</nlm:aff>
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<author><name sortKey="Despierre, Evelyn" sort="Despierre, Evelyn" uniqKey="Despierre E" first="Evelyn" last="Despierre">Evelyn Despierre</name>
<affiliation><nlm:aff id="A10">Division of Gynaecologic Oncology, Department of Obstetrics and Gynaecology, University Hospitals Leuven, University of Leuven, Leuven, 3000 Belgium</nlm:aff>
</affiliation>
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<author><name sortKey="Barrowdale, Daniel" sort="Barrowdale, Daniel" uniqKey="Barrowdale D" first="Daniel" last="Barrowdale">Daniel Barrowdale</name>
<affiliation><nlm:aff id="A11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name>
<affiliation><nlm:aff id="A11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name>
<affiliation><nlm:aff id="A3">Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Herston, QLD 4029, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name>
<affiliation><nlm:aff id="A11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sinilnikova, Olga" sort="Sinilnikova, Olga" uniqKey="Sinilnikova O" first="Olga" last="Sinilnikova">Olga Sinilnikova</name>
<affiliation><nlm:aff id="A12">Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon, Lyon 69373, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A13">Centre Léon Bérard, and Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon 69373, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name>
<affiliation><nlm:aff id="A14">Human Cancer Genetics Programme and Genotyping Unit, Spanish National Cancer Research Centre, Melchor Fernández Almagro 3, Madrid 28029, Spain</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A15">CIBERER, Melchor Fernández Almagro 3, Madrid 28029, Spain</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Garcia, Maria J" sort="Garcia, Maria J" uniqKey="Garcia M" first="María J." last="García">María J. García</name>
<affiliation><nlm:aff id="A15">CIBERER, Melchor Fernández Almagro 3, Madrid 28029, Spain</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A16">Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Melchor Fernández Almagro 3, Madrid 28029, Spain</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Neuhausen, Susan" sort="Neuhausen, Susan" uniqKey="Neuhausen S" first="Susan" last="Neuhausen">Susan Neuhausen</name>
<affiliation><nlm:aff id="A17">Department of Population Sciences, the Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gail, Mitchell H" sort="Gail, Mitchell H" uniqKey="Gail M" first="Mitchell H." last="Gail">Mitchell H. Gail</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda MD 20892, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hartge, Patricia" sort="Hartge, Patricia" uniqKey="Hartge P" first="Patricia" last="Hartge">Patricia Hartge</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda MD 20892, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Peock, Susan" sort="Peock, Susan" uniqKey="Peock S" first="Susan" last="Peock">Susan Peock</name>
<affiliation><nlm:aff id="A11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Frost, Debra" sort="Frost, Debra" uniqKey="Frost D" first="Debra" last="Frost">Debra Frost</name>
<affiliation><nlm:aff id="A11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Evans, D Gareth" sort="Evans, D Gareth" uniqKey="Evans D" first="D. Gareth" last="Evans">D. Gareth Evans</name>
<affiliation><nlm:aff id="A18">Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, M13 9WL UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Eeles, Ros" sort="Eeles, Ros" uniqKey="Eeles R" first="Ros" last="Eeles">Ros Eeles</name>
<affiliation><nlm:aff id="A19">Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, SM2 5NG UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K." last="Godwin">Andrew K. Godwin</name>
<affiliation><nlm:aff id="A20">Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, Kansas City, KS 66160, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B." last="Daly">Mary B. Daly</name>
<affiliation><nlm:aff id="A21">Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA 19111, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kwong, Ava" sort="Kwong, Ava" uniqKey="Kwong A" first="Ava" last="Kwong">Ava Kwong</name>
<affiliation><nlm:aff id="A22">The Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Centre, Hong Kong Sanatorium and Hospital, 4/F, Central Block, 2 Village Road, Hong Kong</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A23">Division of Breast Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ma, Edmond Sk" sort="Ma, Edmond Sk" uniqKey="Ma E" first="Edmond Sk" last="Ma">Edmond Sk Ma</name>
<affiliation><nlm:aff id="A22">The Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Centre, Hong Kong Sanatorium and Hospital, 4/F, Central Block, 2 Village Road, Hong Kong</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A24">Division of Molecular Pathology, Hong Kong Sanatorium and Hospital, 4/F, Central Block, 2 Village Road, Hong Kong</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lazaro, Conxi" sort="Lazaro, Conxi" uniqKey="Lazaro C" first="Conxi" last="Lázaro">Conxi Lázaro</name>
<affiliation><nlm:aff id="A25">Hereditary Cancer Programme, Catalan Institute of Oncology, IDIBELL, Gran Via 199-203, L’Hospitalet, Barcelona 08907, Spain</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Blanco, Ignacio" sort="Blanco, Ignacio" uniqKey="Blanco I" first="Ignacio" last="Blanco">Ignacio Blanco</name>
<affiliation><nlm:aff id="A25">Hereditary Cancer Programme, Catalan Institute of Oncology, IDIBELL, Gran Via 199-203, L’Hospitalet, Barcelona 08907, Spain</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name>
<affiliation><nlm:aff id="A26">Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto - IRCCS, Via Gattamelata 64, 35128 Padua, Italy</nlm:aff>
</affiliation>
</author>
<author><name sortKey="D Ndrea, Emma" sort="D Ndrea, Emma" uniqKey="D Ndrea E" first="Emma" last="D Ndrea">Emma D Ndrea</name>
<affiliation><nlm:aff id="A27">Department of Oncology and Surgical Sciences, University of Padua, 35128 Padua, Italy</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A28">Istituto Oncologico Veneto IRCCS, Via Gattamelata 64, 35128 Padua, Italy</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nicoletto, Ornella" sort="Nicoletto, Ornella" uniqKey="Nicoletto O" first="Ornella" last="Nicoletto">Ornella Nicoletto</name>
<affiliation><nlm:aff id="A29">Medical Oncology Unit, Istituto Oncologico Veneto - IRCCS, Via Gattamelata 64, 35128 Padua, Italy</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Investigators, Kconfab" sort="Investigators, Kconfab" uniqKey="Investigators K" first="Kconfab" last="Investigators">Kconfab Investigators</name>
<affiliation><nlm:aff id="A30">Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Johnatty, Sharon E" sort="Johnatty, Sharon E" uniqKey="Johnatty S" first="Sharon E." last="Johnatty">Sharon E. Johnatty</name>
<affiliation><nlm:aff id="A3">Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Herston, QLD 4029, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kj R, Susanne Kruger" sort="Kj R, Susanne Kruger" uniqKey="Kj R S" first="Susanne Krüger" last="Kj R">Susanne Krüger Kj R</name>
<affiliation><nlm:aff id="A31">Department of Virus, Hormones and Cancer, Danish Cancer Society, Copenhagen, 2100 Denmark</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A32">Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, 2100 Denmark</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jensen, Allan" sort="Jensen, Allan" uniqKey="Jensen A" first="Allan" last="Jensen">Allan Jensen</name>
<affiliation><nlm:aff id="A31">Department of Virus, Hormones and Cancer, Danish Cancer Society, Copenhagen, 2100 Denmark</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A32">Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, 2100 Denmark</nlm:aff>
</affiliation>
</author>
<author><name sortKey="H Gdall, Estrid" sort="H Gdall, Estrid" uniqKey="H Gdall E" first="Estrid" last="H Gdall">Estrid H Gdall</name>
<affiliation><nlm:aff id="A31">Department of Virus, Hormones and Cancer, Danish Cancer Society, Copenhagen, 2100 Denmark</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A32">Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, 2100 Denmark</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Goode, Ellen L" sort="Goode, Ellen L" uniqKey="Goode E" first="Ellen L." last="Goode">Ellen L. Goode</name>
<affiliation><nlm:aff id="A33">Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fridley, Brooke L" sort="Fridley, Brooke L" uniqKey="Fridley B" first="Brooke L." last="Fridley">Brooke L. Fridley</name>
<affiliation><nlm:aff id="A33">Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Loud, Jennifer T" sort="Loud, Jennifer T" uniqKey="Loud J" first="Jennifer T." last="Loud">Jennifer T. Loud</name>
<affiliation><nlm:aff id="A34">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville MD 20852, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name>
<affiliation><nlm:aff id="A34">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville MD 20852, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L." last="Mai">Phuong L. Mai</name>
<affiliation><nlm:aff id="A34">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville MD 20852, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chetrit, Angela" sort="Chetrit, Angela" uniqKey="Chetrit A" first="Angela" last="Chetrit">Angela Chetrit</name>
<affiliation><nlm:aff id="A5">Cancer and Radiation Epidemiology Unit, Gertner Institute for Epidemiology and Health Policy, Sheba Medical Center, Tel Hashomer, 52621, Israel</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lubin, Flora" sort="Lubin, Flora" uniqKey="Lubin F" first="Flora" last="Lubin">Flora Lubin</name>
<affiliation><nlm:aff id="A35">Gertner Institute for Epidemiology and Health Policy, Sheba Medical Center, Tel Hashomer, 52621, Israel</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hirsh Yechezkel, Galit" sort="Hirsh Yechezkel, Galit" uniqKey="Hirsh Yechezkel G" first="Galit" last="Hirsh-Yechezkel">Galit Hirsh-Yechezkel</name>
<affiliation><nlm:aff id="A5">Cancer and Radiation Epidemiology Unit, Gertner Institute for Epidemiology and Health Policy, Sheba Medical Center, Tel Hashomer, 52621, Israel</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name>
<affiliation><nlm:aff id="A36">Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, M5G 2C1 Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name>
<affiliation><nlm:aff id="A36">Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, M5G 2C1 Canada</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A37">Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5 Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name>
<affiliation><nlm:aff id="A38">Division of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, The Comprehensive Cancer Center, The Ohio State University, Columbus, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Senter, Leigha" sort="Senter, Leigha" uniqKey="Senter L" first="Leigha" last="Senter">Leigha Senter</name>
<affiliation><nlm:aff id="A39">Clinical Cancer Genetics Program, Division of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, The Ohio State University, Columbus, 43210 USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gore, Martin E" sort="Gore, Martin E" uniqKey="Gore M" first="Martin E." last="Gore">Martin E. Gore</name>
<affiliation><nlm:aff id="A40">Gynecological Oncology Unit, The Royal Marsden Hospital, FulhamRoad, London SW3 6JJ, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gourley, Charlie" sort="Gourley, Charlie" uniqKey="Gourley C" first="Charlie" last="Gourley">Charlie Gourley</name>
<affiliation><nlm:aff id="A41">University of Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XR UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Michie, Caroline O" sort="Michie, Caroline O" uniqKey="Michie C" first="Caroline O" last="Michie">Caroline O. Michie</name>
<affiliation><nlm:aff id="A41">University of Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XR UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Song, Honglin" sort="Song, Honglin" uniqKey="Song H" first="Honglin" last="Song">Honglin Song</name>
<affiliation><nlm:aff id="A42">Cancer Research United Kingdom, Department of Oncology and Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tyrer, Jonathan" sort="Tyrer, Jonathan" uniqKey="Tyrer J" first="Jonathan" last="Tyrer">Jonathan Tyrer</name>
<affiliation><nlm:aff id="A42">Cancer Research United Kingdom, Department of Oncology and Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S." last="Whittemore">Alice S. Whittemore</name>
<affiliation><nlm:aff id="A43">Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mcguire, Valerie" sort="Mcguire, Valerie" uniqKey="Mcguire V" first="Valerie" last="Mcguire">Valerie Mcguire</name>
<affiliation><nlm:aff id="A43">Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sieh, Weiva" sort="Sieh, Weiva" uniqKey="Sieh W" first="Weiva" last="Sieh">Weiva Sieh</name>
<affiliation><nlm:aff id="A43">Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kristoffersson, Ulf" sort="Kristoffersson, Ulf" uniqKey="Kristoffersson U" first="Ulf" last="Kristoffersson">Ulf Kristoffersson</name>
<affiliation><nlm:aff id="A44">Department of Clinical Genetics, University and Regional Laboratories Skåne and Lund University, SE-20502 Lund, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Olsson, H Kan" sort="Olsson, H Kan" uniqKey="Olsson H" first="H Kan" last="Olsson">H Kan Olsson</name>
<affiliation><nlm:aff id="A45">Department of Oncology, Lund University, SE-22185 Lund, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Borg, Ke" sort="Borg, Ke" uniqKey="Borg " first=" Ke" last="Borg"> Ke Borg</name>
<affiliation><nlm:aff id="A45">Department of Oncology, Lund University, SE-22185 Lund, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Levine, Douglas A" sort="Levine, Douglas A" uniqKey="Levine D" first="Douglas A." last="Levine">Douglas A. Levine</name>
<affiliation><nlm:aff id="A46">Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065 USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Steele, Linda" sort="Steele, Linda" uniqKey="Steele L" first="Linda" last="Steele">Linda Steele</name>
<affiliation><nlm:aff id="A17">Department of Population Sciences, the Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Beattie, Mary S" sort="Beattie, Mary S" uniqKey="Beattie M" first="Mary S." last="Beattie">Mary S. Beattie</name>
<affiliation><nlm:aff id="A48">UCSF Cancer Risk Program, San Fransisco, CA 94143, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A49">UCSF Departments of Medicine, San Fransisco, CA 94118, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chan, Salina" sort="Chan, Salina" uniqKey="Chan S" first="Salina" last="Chan">Salina Chan</name>
<affiliation><nlm:aff id="A48">UCSF Cancer Risk Program, San Fransisco, CA 94143, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nussbaum, Robert" sort="Nussbaum, Robert" uniqKey="Nussbaum R" first="Robert" last="Nussbaum">Robert Nussbaum</name>
<affiliation><nlm:aff id="A48">UCSF Cancer Risk Program, San Fransisco, CA 94143, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A49">UCSF Departments of Medicine, San Fransisco, CA 94118, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Moysich, Kirsten B" sort="Moysich, Kirsten B" uniqKey="Moysich K" first="Kirsten B." last="Moysich">Kirsten B. Moysich</name>
<affiliation><nlm:aff id="A50">Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gross, Jenny" sort="Gross, Jenny" uniqKey="Gross J" first="Jenny" last="Gross">Jenny Gross</name>
<affiliation><nlm:aff id="A8">Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048 USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cass, Ilana" sort="Cass, Ilana" uniqKey="Cass I" first="Ilana" last="Cass">Ilana Cass</name>
<affiliation><nlm:aff id="A8">Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048 USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Walsh, Christine" sort="Walsh, Christine" uniqKey="Walsh C" first="Christine" last="Walsh">Christine Walsh</name>
<affiliation><nlm:aff id="A8">Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048 USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Li, Andrew J" sort="Li, Andrew J" uniqKey="Li A" first="Andrew J." last="Li">Andrew J. Li</name>
<affiliation><nlm:aff id="A8">Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048 USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Leuchter, Ronald" sort="Leuchter, Ronald" uniqKey="Leuchter R" first="Ronald" last="Leuchter">Ronald Leuchter</name>
<affiliation><nlm:aff id="A8">Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048 USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gordon, Ora" sort="Gordon, Ora" uniqKey="Gordon O" first="Ora" last="Gordon">Ora Gordon</name>
<affiliation><nlm:aff id="A8">Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048 USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name>
<affiliation><nlm:aff id="A51">Sections of Epidemiology and Genetics, Institute of Cancer Research and Breakthrough Breast Cancer Research Centre, London, SW7 3RP UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gayther, Simon A" sort="Gayther, Simon A" uniqKey="Gayther S" first="Simon A." last="Gayther">Simon A. Gayther</name>
<affiliation><nlm:aff id="A7">Department of Preventive Medicine, Keck School of Medicine University of Southern California, Los Angeles, California, 90033, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda MD 20892, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C." last="Antoniou">Antonis C. Antoniou</name>
<affiliation><nlm:aff id="A11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name>
<affiliation><nlm:aff id="A42">Cancer Research United Kingdom, Department of Oncology and Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">JAMA : the journal of the American Medical Association</title>
<idno type="ISSN">0098-7484</idno>
<idno type="eISSN">1538-3598</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Context</title>
<p id="P1">Approximately 10 percent of women with invasive epithelial ovarian cancer (EOC) carry deleterious germline mutations in <italic>BRCA1</italic>
or <italic>BRCA2</italic>
. A recent report suggested that <italic>BRCA2</italic>
related EOC was associated with an improved prognosis, but the effect of BRCA1 remains unclear.</p>
</sec>
<sec id="S2"><title>Objective</title>
<p id="P2">To characterize the survival of <italic>BRCA</italic>
carriers with EOC compared to non-carriers and to determine whether <italic>BRCA1</italic>
and <italic>BRCA2</italic>
carriers show similar survival patterns.</p>
</sec>
<sec id="S3"><title>Design, Setting, and Participants</title>
<p id="P3">We pooled data from 26 studies on the survival of women with ovarian cancer. This included data on 1,213 EOC cases with pathogenic germline mutations in <italic>BRCA1</italic>
(909) or <italic>BRCA2</italic>
(304) and 2,666 non-carriers recruited and followed for variable times between 1987 and 2010; the median year of diagnosis was 1998.</p>
</sec>
<sec id="S4"><title>Main Outcome Measures</title>
<p id="P4">Five year overall mortality.</p>
</sec>
<sec id="S5"><title>Results</title>
<p id="P5">The five-year overall survival was 36 percent (95% CI: 34–38) for non-carriers, 44 percent (95% CI: 40–48) for <italic>BRCA1</italic>
carriers and 52 percent (95% CI: 46–58) for <italic>BRCA2</italic>
carriers. After adjusting for study and year of diagnosis, <italic>BRCA1</italic>
and <italic>BRCA2</italic>
carriers showed a more favorable survival than non-carriers (<italic>BRCA1</italic>
, HR=0.78; 95% CI=0.68–0.89, P=2×10<sup>−4</sup>
; <italic>BRCA2</italic>
, HR = 0.61; 95% CI=0.50–0.76, P=6×10<sup>−6</sup>
). These survival differences remained after additional adjustment for stage, grade, histology and age at diagnosis (<italic>BRCA1</italic>
, HR=0.73, 95% CI=0.64–0.84, P=2×10<sup>−5</sup>
; <italic>BRCA2</italic>
, HR = 0.49, 95% CI=0.39–0.61, P=3×10<sup>−10</sup>
).</p>
</sec>
<sec id="S6"><title>Conclusions</title>
<p id="P6">Among patients with invasive epithelial ovarian cancer, having a germline mutation in <italic>BRCA1</italic>
or <italic>BRCA2</italic>
was associated with improved 5-year overall survival.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7501160</journal-id>
<journal-id journal-id-type="pubmed-jr-id">5346</journal-id>
<journal-id journal-id-type="nlm-ta">JAMA</journal-id>
<journal-id journal-id-type="iso-abbrev">JAMA</journal-id>
<journal-title-group><journal-title>JAMA : the journal of the American Medical Association</journal-title>
</journal-title-group>
<issn pub-type="ppub">0098-7484</issn>
<issn pub-type="epub">1538-3598</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">22274685</article-id>
<article-id pub-id-type="pmc">3727895</article-id>
<article-id pub-id-type="doi">10.1001/jama.2012.20</article-id>
<article-id pub-id-type="manuscript">NIHMS449532</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Association Between BRCA1 and BRCA2 Mutations and Survival in Women with Invasive Epithelial Ovarian Cancer</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Bolton</surname>
<given-names>Kelly L.</given-names>
</name>
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<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chenevix-Trench</surname>
<given-names>Georgia</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Goh</surname>
<given-names>Cindy</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sadetzki</surname>
<given-names>Siegal</given-names>
</name>
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</contrib>
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<given-names>Susan J.</given-names>
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<given-names>Beth Y.</given-names>
</name>
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</contrib>
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<given-names>Diether</given-names>
</name>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Despierre</surname>
<given-names>Evelyn</given-names>
</name>
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</contrib>
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<given-names>Daniel</given-names>
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<given-names>Lesley</given-names>
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<given-names>Sue</given-names>
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</contrib>
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<given-names>Douglas F.</given-names>
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<xref ref-type="aff" rid="A13">13</xref>
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<given-names>Javier</given-names>
</name>
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</contrib>
<contrib contrib-type="author"><name><surname>García</surname>
<given-names>María J.</given-names>
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<given-names>Susan</given-names>
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</contrib>
<contrib contrib-type="author"><name><surname>Gail</surname>
<given-names>Mitchell H.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hartge</surname>
<given-names>Patricia</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><collab>EMBRACE study team</collab>
<xref ref-type="aff" rid="A11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Peock</surname>
<given-names>Susan</given-names>
</name>
<xref ref-type="aff" rid="A11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Frost</surname>
<given-names>Debra</given-names>
</name>
<xref ref-type="aff" rid="A11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Evans</surname>
<given-names>D. Gareth</given-names>
</name>
<xref ref-type="aff" rid="A18">18</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Eeles</surname>
<given-names>Ros</given-names>
</name>
<xref ref-type="aff" rid="A19">19</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Godwin</surname>
<given-names>Andrew K.</given-names>
</name>
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</contrib>
<contrib contrib-type="author"><name><surname>Daly</surname>
<given-names>Mary B.</given-names>
</name>
<xref ref-type="aff" rid="A21">21</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kwong</surname>
<given-names>Ava</given-names>
</name>
<xref ref-type="aff" rid="A22">22</xref>
<xref ref-type="aff" rid="A23">23</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ma</surname>
<given-names>Edmond SK</given-names>
</name>
<xref ref-type="aff" rid="A22">22</xref>
<xref ref-type="aff" rid="A24">24</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lázaro</surname>
<given-names>Conxi</given-names>
</name>
<xref ref-type="aff" rid="A25">25</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Blanco</surname>
<given-names>Ignacio</given-names>
</name>
<xref ref-type="aff" rid="A25">25</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Montagna</surname>
<given-names>Marco</given-names>
</name>
<xref ref-type="aff" rid="A26">26</xref>
</contrib>
<contrib contrib-type="author"><name><surname>D’Andrea</surname>
<given-names>Emma</given-names>
</name>
<xref ref-type="aff" rid="A27">27</xref>
<xref ref-type="aff" rid="A28">28</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nicoletto</surname>
<given-names>Ornella</given-names>
</name>
<xref ref-type="aff" rid="A29">29</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Investigators</surname>
<given-names>kConFab</given-names>
</name>
<xref ref-type="aff" rid="A30">30</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Johnatty</surname>
<given-names>Sharon E.</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kjær</surname>
<given-names>Susanne Krüger</given-names>
</name>
<xref ref-type="aff" rid="A31">31</xref>
<xref ref-type="aff" rid="A32">32</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jensen</surname>
<given-names>Allan</given-names>
</name>
<xref ref-type="aff" rid="A31">31</xref>
<xref ref-type="aff" rid="A32">32</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Høgdall</surname>
<given-names>Estrid</given-names>
</name>
<xref ref-type="aff" rid="A31">31</xref>
<xref ref-type="aff" rid="A32">32</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Goode</surname>
<given-names>Ellen L.</given-names>
</name>
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</contrib>
<contrib contrib-type="author"><name><surname>Fridley</surname>
<given-names>Brooke L.</given-names>
</name>
<xref ref-type="aff" rid="A33">33</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Loud</surname>
<given-names>Jennifer T.</given-names>
</name>
<xref ref-type="aff" rid="A34">34</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Greene</surname>
<given-names>Mark H.</given-names>
</name>
<xref ref-type="aff" rid="A34">34</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mai</surname>
<given-names>Phuong L.</given-names>
</name>
<xref ref-type="aff" rid="A34">34</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chetrit</surname>
<given-names>Angela</given-names>
</name>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lubin</surname>
<given-names>Flora</given-names>
</name>
<xref ref-type="aff" rid="A35">35</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hirsh-Yechezkel</surname>
<given-names>Galit</given-names>
</name>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Glendon</surname>
<given-names>Gord</given-names>
</name>
<xref ref-type="aff" rid="A36">36</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Andrulis</surname>
<given-names>Irene L.</given-names>
</name>
<xref ref-type="aff" rid="A36">36</xref>
<xref ref-type="aff" rid="A37">37</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Toland</surname>
<given-names>Amanda E.</given-names>
</name>
<xref ref-type="aff" rid="A38">38</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Senter</surname>
<given-names>Leigha</given-names>
</name>
<xref ref-type="aff" rid="A39">39</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gore</surname>
<given-names>Martin E.</given-names>
</name>
<xref ref-type="aff" rid="A40">40</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gourley</surname>
<given-names>Charlie</given-names>
</name>
<xref ref-type="aff" rid="A41">41</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Michie</surname>
<given-names>Caroline O</given-names>
</name>
<xref ref-type="aff" rid="A41">41</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Song</surname>
<given-names>Honglin</given-names>
</name>
<xref ref-type="aff" rid="A42">42</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tyrer</surname>
<given-names>Jonathan</given-names>
</name>
<xref ref-type="aff" rid="A42">42</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Whittemore</surname>
<given-names>Alice S.</given-names>
</name>
<xref ref-type="aff" rid="A43">43</xref>
</contrib>
<contrib contrib-type="author"><name><surname>McGuire</surname>
<given-names>Valerie</given-names>
</name>
<xref ref-type="aff" rid="A43">43</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sieh</surname>
<given-names>Weiva</given-names>
</name>
<xref ref-type="aff" rid="A43">43</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kristoffersson</surname>
<given-names>Ulf</given-names>
</name>
<xref ref-type="aff" rid="A44">44</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Olsson</surname>
<given-names>Håkan</given-names>
</name>
<xref ref-type="aff" rid="A45">45</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Borg</surname>
<given-names>Åke</given-names>
</name>
<xref ref-type="aff" rid="A45">45</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Levine</surname>
<given-names>Douglas A.</given-names>
</name>
<xref ref-type="aff" rid="A46">46</xref>
</contrib>
<contrib contrib-type="author"><collab>Cancer Genome Atlas Research Network</collab>
<xref ref-type="aff" rid="A47">47</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Steele</surname>
<given-names>Linda</given-names>
</name>
<xref ref-type="aff" rid="A17">17</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Beattie</surname>
<given-names>Mary S.</given-names>
</name>
<xref ref-type="aff" rid="A48">48</xref>
<xref ref-type="aff" rid="A49">49</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chan</surname>
<given-names>Salina</given-names>
</name>
<xref ref-type="aff" rid="A48">48</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nussbaum</surname>
<given-names>Robert</given-names>
</name>
<xref ref-type="aff" rid="A48">48</xref>
<xref ref-type="aff" rid="A49">49</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Moysich</surname>
<given-names>Kirsten B.</given-names>
</name>
<xref ref-type="aff" rid="A50">50</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gross</surname>
<given-names>Jenny</given-names>
</name>
<xref ref-type="aff" rid="A8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cass</surname>
<given-names>Ilana</given-names>
</name>
<xref ref-type="aff" rid="A8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Walsh</surname>
<given-names>Christine</given-names>
</name>
<xref ref-type="aff" rid="A8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Li</surname>
<given-names>Andrew J.</given-names>
</name>
<xref ref-type="aff" rid="A8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Leuchter</surname>
<given-names>Ronald</given-names>
</name>
<xref ref-type="aff" rid="A8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gordon</surname>
<given-names>Ora</given-names>
</name>
<xref ref-type="aff" rid="A8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Garcia-Closas</surname>
<given-names>Montserrat</given-names>
</name>
<xref ref-type="aff" rid="A51">51</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gayther</surname>
<given-names>Simon A.</given-names>
</name>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chanock</surname>
<given-names>Stephen J.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Antoniou</surname>
<given-names>Antonis C.</given-names>
</name>
<xref ref-type="aff" rid="A11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pharoah</surname>
<given-names>Paul D.P.</given-names>
</name>
<xref ref-type="aff" rid="A42">42</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda MD 20892, USA</aff>
<aff id="A2"><label>2</label>
David Geffen School of Medicine at the University of California, Los Angeles CA 90095, USA</aff>
<aff id="A3"><label>3</label>
Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Herston, QLD 4029, Australia</aff>
<aff id="A4"><label>4</label>
Addenbrooke’s Hospital, Hills Road, Cambridge CB2 OQQ, UK</aff>
<aff id="A5"><label>5</label>
Cancer and Radiation Epidemiology Unit, Gertner Institute for Epidemiology and Health Policy, Sheba Medical Center, Tel Hashomer, 52621, Israel</aff>
<aff id="A6"><label>6</label>
Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, 69978 Israel</aff>
<aff id="A7"><label>7</label>
Department of Preventive Medicine, Keck School of Medicine University of Southern California, Los Angeles, California, 90033, USA</aff>
<aff id="A8"><label>8</label>
Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048 USA</aff>
<aff id="A9"><label>9</label>
VIB Vesalius Research Center, University of Leuven, Leuven, 3000 Belgium</aff>
<aff id="A10"><label>10</label>
Division of Gynaecologic Oncology, Department of Obstetrics and Gynaecology, University Hospitals Leuven, University of Leuven, Leuven, 3000 Belgium</aff>
<aff id="A11"><label>11</label>
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK</aff>
<aff id="A12"><label>12</label>
Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon, Lyon 69373, France</aff>
<aff id="A13"><label>13</label>
Centre Léon Bérard, and Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon 69373, France</aff>
<aff id="A14"><label>14</label>
Human Cancer Genetics Programme and Genotyping Unit, Spanish National Cancer Research Centre, Melchor Fernández Almagro 3, Madrid 28029, Spain</aff>
<aff id="A15"><label>15</label>
CIBERER, Melchor Fernández Almagro 3, Madrid 28029, Spain</aff>
<aff id="A16"><label>16</label>
Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Melchor Fernández Almagro 3, Madrid 28029, Spain</aff>
<aff id="A17"><label>17</label>
Department of Population Sciences, the Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA</aff>
<aff id="A18"><label>18</label>
Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, M13 9WL UK</aff>
<aff id="A19"><label>19</label>
Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, SM2 5NG UK</aff>
<aff id="A20"><label>20</label>
Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, Kansas City, KS 66160, USA</aff>
<aff id="A21"><label>21</label>
Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA 19111, USA</aff>
<aff id="A22"><label>22</label>
The Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Centre, Hong Kong Sanatorium and Hospital, 4/F, Central Block, 2 Village Road, Hong Kong</aff>
<aff id="A23"><label>23</label>
Division of Breast Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong</aff>
<aff id="A24"><label>24</label>
Division of Molecular Pathology, Hong Kong Sanatorium and Hospital, 4/F, Central Block, 2 Village Road, Hong Kong</aff>
<aff id="A25"><label>25</label>
Hereditary Cancer Programme, Catalan Institute of Oncology, IDIBELL, Gran Via 199-203, L’Hospitalet, Barcelona 08907, Spain</aff>
<aff id="A26"><label>26</label>
Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto - IRCCS, Via Gattamelata 64, 35128 Padua, Italy</aff>
<aff id="A27"><label>27</label>
Department of Oncology and Surgical Sciences, University of Padua, 35128 Padua, Italy</aff>
<aff id="A28"><label>28</label>
Istituto Oncologico Veneto IRCCS, Via Gattamelata 64, 35128 Padua, Italy</aff>
<aff id="A29"><label>29</label>
Medical Oncology Unit, Istituto Oncologico Veneto - IRCCS, Via Gattamelata 64, 35128 Padua, Italy</aff>
<aff id="A30"><label>30</label>
Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia</aff>
<aff id="A31"><label>31</label>
Department of Virus, Hormones and Cancer, Danish Cancer Society, Copenhagen, 2100 Denmark</aff>
<aff id="A32"><label>32</label>
Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, 2100 Denmark</aff>
<aff id="A33"><label>33</label>
Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA</aff>
<aff id="A34"><label>34</label>
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville MD 20852, USA</aff>
<aff id="A35"><label>35</label>
Gertner Institute for Epidemiology and Health Policy, Sheba Medical Center, Tel Hashomer, 52621, Israel</aff>
<aff id="A36"><label>36</label>
Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, M5G 2C1 Canada</aff>
<aff id="A37"><label>37</label>
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5 Canada</aff>
<aff id="A38"><label>38</label>
Division of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, The Comprehensive Cancer Center, The Ohio State University, Columbus, USA</aff>
<aff id="A39"><label>39</label>
Clinical Cancer Genetics Program, Division of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, The Ohio State University, Columbus, 43210 USA</aff>
<aff id="A40"><label>40</label>
Gynecological Oncology Unit, The Royal Marsden Hospital, FulhamRoad, London SW3 6JJ, UK</aff>
<aff id="A41"><label>41</label>
University of Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XR UK</aff>
<aff id="A42"><label>42</label>
Cancer Research United Kingdom, Department of Oncology and Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK</aff>
<aff id="A43"><label>43</label>
Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA</aff>
<aff id="A44"><label>44</label>
Department of Clinical Genetics, University and Regional Laboratories Skåne and Lund University, SE-20502 Lund, Sweden</aff>
<aff id="A45"><label>45</label>
Department of Oncology, Lund University, SE-22185 Lund, Sweden</aff>
<aff id="A46"><label>46</label>
Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065 USA</aff>
<aff id="A47"><label>47</label>
National Cancer Institute at National Institutes of Health, Bethesda, MD 20892, USA</aff>
<aff id="A48"><label>48</label>
UCSF Cancer Risk Program, San Fransisco, CA 94143, USA</aff>
<aff id="A49"><label>49</label>
UCSF Departments of Medicine, San Fransisco, CA 94118, USA</aff>
<aff id="A50"><label>50</label>
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA</aff>
<aff id="A51"><label>51</label>
Sections of Epidemiology and Genetics, Institute of Cancer Research and Breakthrough Breast Cancer Research Centre, London, SW7 3RP UK</aff>
<pub-date pub-type="nihms-submitted"><day>18</day>
<month>3</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="ppub"><day>25</day>
<month>1</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>30</day>
<month>7</month>
<year>2013</year>
</pub-date>
<volume>307</volume>
<issue>4</issue>
<fpage>382</fpage>
<lpage>390</lpage>
<abstract><sec id="S1"><title>Context</title>
<p id="P1">Approximately 10 percent of women with invasive epithelial ovarian cancer (EOC) carry deleterious germline mutations in <italic>BRCA1</italic>
or <italic>BRCA2</italic>
. A recent report suggested that <italic>BRCA2</italic>
related EOC was associated with an improved prognosis, but the effect of BRCA1 remains unclear.</p>
</sec>
<sec id="S2"><title>Objective</title>
<p id="P2">To characterize the survival of <italic>BRCA</italic>
carriers with EOC compared to non-carriers and to determine whether <italic>BRCA1</italic>
and <italic>BRCA2</italic>
carriers show similar survival patterns.</p>
</sec>
<sec id="S3"><title>Design, Setting, and Participants</title>
<p id="P3">We pooled data from 26 studies on the survival of women with ovarian cancer. This included data on 1,213 EOC cases with pathogenic germline mutations in <italic>BRCA1</italic>
(909) or <italic>BRCA2</italic>
(304) and 2,666 non-carriers recruited and followed for variable times between 1987 and 2010; the median year of diagnosis was 1998.</p>
</sec>
<sec id="S4"><title>Main Outcome Measures</title>
<p id="P4">Five year overall mortality.</p>
</sec>
<sec id="S5"><title>Results</title>
<p id="P5">The five-year overall survival was 36 percent (95% CI: 34–38) for non-carriers, 44 percent (95% CI: 40–48) for <italic>BRCA1</italic>
carriers and 52 percent (95% CI: 46–58) for <italic>BRCA2</italic>
carriers. After adjusting for study and year of diagnosis, <italic>BRCA1</italic>
and <italic>BRCA2</italic>
carriers showed a more favorable survival than non-carriers (<italic>BRCA1</italic>
, HR=0.78; 95% CI=0.68–0.89, P=2×10<sup>−4</sup>
; <italic>BRCA2</italic>
, HR = 0.61; 95% CI=0.50–0.76, P=6×10<sup>−6</sup>
). These survival differences remained after additional adjustment for stage, grade, histology and age at diagnosis (<italic>BRCA1</italic>
, HR=0.73, 95% CI=0.64–0.84, P=2×10<sup>−5</sup>
; <italic>BRCA2</italic>
, HR = 0.49, 95% CI=0.39–0.61, P=3×10<sup>−10</sup>
).</p>
</sec>
<sec id="S6"><title>Conclusions</title>
<p id="P6">Among patients with invasive epithelial ovarian cancer, having a germline mutation in <italic>BRCA1</italic>
or <italic>BRCA2</italic>
was associated with improved 5-year overall survival.</p>
</sec>
</abstract>
<funding-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source>
<award-id>R01 CA122443 || CA</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
</record>
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