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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy</title><author><name sortKey="Kovacs, Gabor G" sort="Kovacs, Gabor G" uniqKey="Kovacs G" first="Gabor G." last="Kovacs">Gabor G. Kovacs</name><affiliation><nlm:aff id="A1">Institute of Neurology, Medical University of Vienna, AKH 4J, Währinger Gürtel 18-20, 1097 Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Ferrer, Isidro" sort="Ferrer, Isidro" uniqKey="Ferrer I" first="Isidro" last="Ferrer">Isidro Ferrer</name><affiliation><nlm:aff id="A2">Institute of Neuropathology, Bellvitge University Hospital, University of Barcelona, Hospitalet de Llobregat, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Grinberg, Lea T" sort="Grinberg, Lea T" uniqKey="Grinberg L" first="Lea T." last="Grinberg">Lea T. Grinberg</name><affiliation><nlm:aff id="A3">Department of Neurology, Memory and Aging Center, University of California, San Francisco, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Pathology, LIM-22, University of Sao Paulo Medical School, Sao Paulo, Brazil</nlm:aff></affiliation></author><author><name sortKey="Alafuzoff, Irina" sort="Alafuzoff, Irina" uniqKey="Alafuzoff I" first="Irina" last="Alafuzoff">Irina Alafuzoff</name><affiliation><nlm:aff id="A5">Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Attems, Johannes" sort="Attems, Johannes" uniqKey="Attems J" first="Johannes" last="Attems">Johannes Attems</name><affiliation><nlm:aff id="A6">Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK</nlm:aff></affiliation></author><author><name sortKey="Budka, Herbert" sort="Budka, Herbert" uniqKey="Budka H" first="Herbert" last="Budka">Herbert Budka</name><affiliation><nlm:aff id="A7">Institute of Neuropathology, University Hospital Zürich, Zurich, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Cairns, Nigel J" sort="Cairns, Nigel J" uniqKey="Cairns N" first="Nigel J." last="Cairns">Nigel J. Cairns</name><affiliation><nlm:aff id="A8">Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA</nlm:aff></affiliation></author><author><name sortKey="Crary, John F" sort="Crary, John F" uniqKey="Crary J" first="John F." last="Crary">John F. Crary</name><affiliation><nlm:aff id="A9">Department of Pathology, Friedman Brain Institute, and the Ronald M. Loeb Center for Alzheimer’s Disease, Icahn School of Medicine at Mount Sinai, New York, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Fishberg Department of Neuroscience, Friedman Brain Institute, and Ronald M. Loeb Center for Alzheimer’s Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</nlm:aff></affiliation></author><author><name sortKey="Duyckaerts, Charles" sort="Duyckaerts, Charles" uniqKey="Duyckaerts C" first="Charles" last="Duyckaerts">Charles Duyckaerts</name><affiliation><nlm:aff id="A10">Neuropathology Department, Hopital de La Salpetrière, AP-HP, UPMC-Sorbonne-University, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Ghetti, Bernardino" sort="Ghetti, Bernardino" uniqKey="Ghetti B" first="Bernardino" last="Ghetti">Bernardino Ghetti</name><affiliation><nlm:aff id="A11">Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA</nlm:aff></affiliation></author><author><name sortKey="Halliday, Glenda M" sort="Halliday, Glenda M" uniqKey="Halliday G" first="Glenda M." last="Halliday">Glenda M. Halliday</name><affiliation><nlm:aff id="A12">GMH-Neuroscience Research Australia and the University of New South Wales, Sydney, NSW, Australia</nlm:aff></affiliation></author><author><name sortKey="Ironside, James W" sort="Ironside, James W" uniqKey="Ironside J" first="James W." last="Ironside">James W. Ironside</name><affiliation><nlm:aff id="A13">Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Love, Seth" sort="Love, Seth" uniqKey="Love S" first="Seth" last="Love">Seth Love</name><affiliation><nlm:aff id="A14">Institute of Clinical Neurosciences, University of Bristol, Learning and Research Level 2, Southmead Hospital, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Mackenzie, Ian R" sort="Mackenzie, Ian R" uniqKey="Mackenzie I" first="Ian R." last="Mackenzie">Ian R. Mackenzie</name><affiliation><nlm:aff id="A15">Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada</nlm:aff></affiliation></author><author><name sortKey="Munoz, David G" sort="Munoz, David G" uniqKey="Munoz D" first="David G." last="Munoz">David G. Munoz</name><affiliation><nlm:aff id="A16">Division of Pathology, St. Michael’s Hospital, 30 Bond St, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Murray, Melissa E" sort="Murray, Melissa E" uniqKey="Murray M" first="Melissa E." last="Murray">Melissa E. Murray</name><affiliation><nlm:aff id="A17">Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA</nlm:aff></affiliation></author><author><name sortKey="Nelson, Peter T" sort="Nelson, Peter T" uniqKey="Nelson P" first="Peter T." last="Nelson">Peter T. Nelson</name><affiliation><nlm:aff id="A18">Department of Pathology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA</nlm:aff></affiliation></author><author><name sortKey="Takahashi, Hitoshi" sort="Takahashi, Hitoshi" uniqKey="Takahashi H" first="Hitoshi" last="Takahashi">Hitoshi Takahashi</name><affiliation><nlm:aff id="A19">Department of Pathology, Brain Research Institute, Niigata University, Niigata 951-8585, Japan</nlm:aff></affiliation></author><author><name sortKey="Trojanowski, John Q" sort="Trojanowski, John Q" uniqKey="Trojanowski J" first="John Q." last="Trojanowski">John Q. Trojanowski</name><affiliation><nlm:aff id="A20">Department of Pathology and Laboratory Medicine of the Perelman School of Medicine, Center for Neurodegenerative Disease Research, Institute On Aging, University of Pennsylvania, Philadelphia, USA</nlm:aff></affiliation></author><author><name sortKey="Ansorge, Olaf" sort="Ansorge, Olaf" uniqKey="Ansorge O" first="Olaf" last="Ansorge">Olaf Ansorge</name><affiliation><nlm:aff id="A21">Department of Neuropathology, John Radcliffe Hospital, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Arzberger, Thomas" sort="Arzberger, Thomas" uniqKey="Arzberger T" first="Thomas" last="Arzberger">Thomas Arzberger</name><affiliation><nlm:aff id="A22">Department of Psychiatry and Psychotherapy, Centre for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Baborie, Atik" sort="Baborie, Atik" uniqKey="Baborie A" first="Atik" last="Baborie">Atik Baborie</name><affiliation><nlm:aff id="A23">Department of Neuropathology, Walton Centre, Liverpool, UK</nlm:aff></affiliation></author><author><name sortKey="Beach, Thomas G" sort="Beach, Thomas G" uniqKey="Beach T" first="Thomas G." last="Beach">Thomas G. Beach</name><affiliation><nlm:aff id="A24">Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ 85351, USA</nlm:aff></affiliation></author><author><name sortKey="Bieniek, Kevin F" sort="Bieniek, Kevin F" uniqKey="Bieniek K" first="Kevin F." last="Bieniek">Kevin F. Bieniek</name><affiliation><nlm:aff id="A17">Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA</nlm:aff></affiliation></author><author><name sortKey="Bigio, Eileen H" sort="Bigio, Eileen H" uniqKey="Bigio E" first="Eileen H." last="Bigio">Eileen H. Bigio</name><affiliation><nlm:aff id="A25">Northwestern ADC Neuropathology Core, Northwestern University Feinberg School of Medicine, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Bodi, Istvan" sort="Bodi, Istvan" uniqKey="Bodi I" first="Istvan" last="Bodi">Istvan Bodi</name><affiliation><nlm:aff id="A26">Clinical Neuropathology, King’s College Hospital, London Neurodegenerative Brain Bank, London, UK</nlm:aff></affiliation></author><author><name sortKey="Dugger, Brittany N" sort="Dugger, Brittany N" uniqKey="Dugger B" first="Brittany N." last="Dugger">Brittany N. Dugger</name><affiliation><nlm:aff id="A24">Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ 85351, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Institute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Feany, Mel" sort="Feany, Mel" uniqKey="Feany M" first="Mel" last="Feany">Mel Feany</name><affiliation><nlm:aff id="A28">Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Gelpi, Ellen" sort="Gelpi, Ellen" uniqKey="Gelpi E" first="Ellen" last="Gelpi">Ellen Gelpi</name><affiliation><nlm:aff id="A29">Neurological Tissue Bank of the Biobank-Hospital Clinic-IDIBAPS, Institut d’Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Gentleman, Stephen M" sort="Gentleman, Stephen M" uniqKey="Gentleman S" first="Stephen M." last="Gentleman">Stephen M. Gentleman</name><affiliation><nlm:aff id="A30">Department of Medicine, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Giaccone, Giorgio" sort="Giaccone, Giorgio" uniqKey="Giaccone G" first="Giorgio" last="Giaccone">Giorgio Giaccone</name><affiliation><nlm:aff id="A31">IRCCS Foundation “Carlo Besta” Neurological Institute, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Hatanpaa, Kimmo J" sort="Hatanpaa, Kimmo J" uniqKey="Hatanpaa K" first="Kimmo J." last="Hatanpaa">Kimmo J. Hatanpaa</name><affiliation><nlm:aff id="A32">Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Heale, Richard" sort="Heale, Richard" uniqKey="Heale R" first="Richard" last="Heale">Richard Heale</name><affiliation><nlm:aff id="A6">Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK</nlm:aff></affiliation></author><author><name sortKey="Hof, Patrick R" sort="Hof, Patrick R" uniqKey="Hof P" first="Patrick R." last="Hof">Patrick R. Hof</name><affiliation><nlm:aff id="A33">Fishberg Department of Neuroscience, Friedman Brain Institute, and Ronald M. Loeb Center for Alzheimer’s Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</nlm:aff></affiliation></author><author><name sortKey="Hofer, Monika" sort="Hofer, Monika" uniqKey="Hofer M" first="Monika" last="Hofer">Monika Hofer</name><affiliation><nlm:aff id="A21">Department of Neuropathology, John Radcliffe Hospital, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Hortobagyi, Tibor" sort="Hortobagyi, Tibor" uniqKey="Hortobagyi T" first="Tibor" last="Hortobágyi">Tibor Hortobágyi</name><affiliation><nlm:aff id="A34">Department of Neuropathology, Faculty of Medicine, Institute of Pathology, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary</nlm:aff></affiliation></author><author><name sortKey="Jellinger, Kurt" sort="Jellinger, Kurt" uniqKey="Jellinger K" first="Kurt" last="Jellinger">Kurt Jellinger</name><affiliation><nlm:aff id="A35">Institute of Clinical Neurobiology, Alberichgasse 5/13, 1150 Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Jicha, Gregory A" sort="Jicha, Gregory A" uniqKey="Jicha G" first="Gregory A." last="Jicha">Gregory A. Jicha</name><affiliation><nlm:aff id="A36">Department of Neurology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA</nlm:aff></affiliation></author><author><name sortKey="Ince, Paul" sort="Ince, Paul" uniqKey="Ince P" first="Paul" last="Ince">Paul Ince</name><affiliation><nlm:aff id="A37">Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Kofler, Julia" sort="Kofler, Julia" uniqKey="Kofler J" first="Julia" last="Kofler">Julia Kofler</name><affiliation><nlm:aff id="A38">Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Kovari, Eniko" sort="Kovari, Eniko" uniqKey="Kovari E" first="Enikö" last="Kövari">Enikö Kövari</name><affiliation><nlm:aff id="A39">Department of Mental Health and Psychiatry, University Hospitals and University of Geneva School of Medicine, Geneva, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Kril, Jillian J" sort="Kril, Jillian J" uniqKey="Kril J" first="Jillian J." last="Kril">Jillian J. Kril</name><affiliation><nlm:aff id="A40">Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia</nlm:aff></affiliation></author><author><name sortKey="Mann, David M" sort="Mann, David M" uniqKey="Mann D" first="David M." last="Mann">David M. Mann</name><affiliation><nlm:aff id="A41">Institute of Brain, Behaviour and Mental Health, Manchester University Faculty of Medical and Health Sciences, Manchester, UK</nlm:aff></affiliation></author><author><name sortKey="Matej, Radoslav" sort="Matej, Radoslav" uniqKey="Matej R" first="Radoslav" last="Matej">Radoslav Matej</name><affiliation><nlm:aff id="A42">Department of Pathology and Molecular Medicine, Thomayer Hospital, Prague 4, Czech Republic</nlm:aff></affiliation></author><author><name sortKey="Mckee, Ann C" sort="Mckee, Ann C" uniqKey="Mckee A" first="Ann C." last="Mckee">Ann C. Mckee</name><affiliation><nlm:aff id="A43">Department of Neurology and Pathology, Boston University School of Medicine and VA Healthcare System, Boston, MA 02118, USA</nlm:aff></affiliation></author><author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name><affiliation><nlm:aff id="A44">Department of Anatomical Pathology, Alfred Hospital, Prahran, VIC 3004, Australia</nlm:aff></affiliation></author><author><name sortKey="Milenkovic, Ivan" sort="Milenkovic, Ivan" uniqKey="Milenkovic I" first="Ivan" last="Milenkovic">Ivan Milenkovic</name><affiliation><nlm:aff id="A1">Institute of Neurology, Medical University of Vienna, AKH 4J, Währinger Gürtel 18-20, 1097 Vienna, Austria</nlm:aff></affiliation><affiliation><nlm:aff id="A45">Department of Neurology, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas J." last="Montine">Thomas J. Montine</name><affiliation><nlm:aff id="A46">Department of Pathology, University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Murayama, Shigeo" sort="Murayama, Shigeo" uniqKey="Murayama S" first="Shigeo" last="Murayama">Shigeo Murayama</name><affiliation><nlm:aff id="A47">Department of Neuropathology (The Brain Bank for Aging Research), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Lee, Edward B" sort="Lee, Edward B" uniqKey="Lee E" first="Edward B." last="Lee">Edward B. Lee</name><affiliation><nlm:aff id="A20">Department of Pathology and Laboratory Medicine of the Perelman School of Medicine, Center for Neurodegenerative Disease Research, Institute On Aging, University of Pennsylvania, Philadelphia, USA</nlm:aff></affiliation></author><author><name sortKey="Rahimi, Jasmin" sort="Rahimi, Jasmin" uniqKey="Rahimi J" first="Jasmin" last="Rahimi">Jasmin Rahimi</name><affiliation><nlm:aff id="A1">Institute of Neurology, Medical University of Vienna, AKH 4J, Währinger Gürtel 18-20, 1097 Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Rodriguez, Roberta D" sort="Rodriguez, Roberta D" uniqKey="Rodriguez R" first="Roberta D." last="Rodriguez">Roberta D. Rodriguez</name><affiliation><nlm:aff id="A48">Physiopathology in Aging Lab/Brazilian Aging Brain Study Group-LIM22, University of Sao Paulo Medical School, Sao Paulo, Brazil</nlm:aff></affiliation></author><author><name sortKey="Rozemuller, Annemieke" sort="Rozemuller, Annemieke" uniqKey="Rozemuller A" first="Annemieke" last="Rozemüller">Annemieke Rozemüller</name><affiliation><nlm:aff id="A49">Netherlands Brainbank and Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Schneider, Julie A" sort="Schneider, Julie A" uniqKey="Schneider J" first="Julie A." last="Schneider">Julie A. Schneider</name><affiliation><nlm:aff id="A50">Department of Pathology, Rush University Medical Center, Chicago, IL, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A51">Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Schultz, Christian" sort="Schultz, Christian" uniqKey="Schultz C" first="Christian" last="Schultz">Christian Schultz</name><affiliation><nlm:aff id="A52">Institute of Neuroanatomy, Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Seeley, William" sort="Seeley, William" uniqKey="Seeley W" first="William" last="Seeley">William Seeley</name><affiliation><nlm:aff id="A3">Department of Neurology, Memory and Aging Center, University of California, San Francisco, USA</nlm:aff></affiliation></author><author><name sortKey="Seilhean, Danielle" sort="Seilhean, Danielle" uniqKey="Seilhean D" first="Danielle" last="Seilhean">Danielle Seilhean</name><affiliation><nlm:aff id="A10">Neuropathology Department, Hopital de La Salpetrière, AP-HP, UPMC-Sorbonne-University, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Smith, Colin" sort="Smith, Colin" uniqKey="Smith C" first="Colin" last="Smith">Colin Smith</name><affiliation><nlm:aff id="A13">Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Tagliavini, Fabrizio" sort="Tagliavini, Fabrizio" uniqKey="Tagliavini F" first="Fabrizio" last="Tagliavini">Fabrizio Tagliavini</name><affiliation><nlm:aff id="A31">IRCCS Foundation “Carlo Besta” Neurological Institute, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Takao, Masaki" sort="Takao, Masaki" uniqKey="Takao M" first="Masaki" last="Takao">Masaki Takao</name><affiliation><nlm:aff id="A53">Department of Neurology, Saitama Medical University International Medical Center, Saitama, Japan</nlm:aff></affiliation></author><author><name sortKey="Thal, Dietmar Rudolf" sort="Thal, Dietmar Rudolf" uniqKey="Thal D" first="Dietmar Rudolf" last="Thal">Dietmar Rudolf Thal</name><affiliation><nlm:aff id="A54">Laboratory of Neuropathology, Institute of Pathology, University of Ulm, 89081 Ulm, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Department of Neuroscience, KU-Leuven, 3000 Louvain, Belgium</nlm:aff></affiliation></author><author><name sortKey="Toledo, Jon B" sort="Toledo, Jon B" uniqKey="Toledo J" first="Jon B." last="Toledo">Jon B. Toledo</name><affiliation><nlm:aff id="A20">Department of Pathology and Laboratory Medicine of the Perelman School of Medicine, Center for Neurodegenerative Disease Research, Institute On Aging, University of Pennsylvania, Philadelphia, USA</nlm:aff></affiliation></author><author><name sortKey="Tolnay, Markus" sort="Tolnay, Markus" uniqKey="Tolnay M" first="Markus" last="Tolnay">Markus Tolnay</name><affiliation><nlm:aff id="A56">Institute of Pathology, University Hospital Basel, Basel, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Troncoso, Juan C" sort="Troncoso, Juan C" uniqKey="Troncoso J" first="Juan C." last="Troncoso">Juan C. Troncoso</name><affiliation><nlm:aff id="A57">Division of Neuropathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Vinters, Harry V" sort="Vinters, Harry V" uniqKey="Vinters H" first="Harry V." last="Vinters">Harry V. Vinters</name><affiliation><nlm:aff id="A58">Section of Neuropathology, Department of Pathology and Laboratory Medicine, Brain Research Institute, University of California, Los Angeles (UCLA) Medical Center and David Geffen School of Medicine, Los Angeles, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A59">Department of Neurology, Brain Research Institute, University of California, Los Angeles (UCLA) Medical Center and David Geffen School of Medicine, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Weis, Serge" sort="Weis, Serge" uniqKey="Weis S" first="Serge" last="Weis">Serge Weis</name><affiliation><nlm:aff id="A60">Department of Pathology and Neuropathology, Laboratory of Neuropathology, Neuromed Campus, Kepler University Hospital, Medical School, Johannes Kepler University, Linz, Austria</nlm:aff></affiliation></author><author><name sortKey="Wharton, Stephen B" sort="Wharton, Stephen B" uniqKey="Wharton S" first="Stephen B." last="Wharton">Stephen B. Wharton</name><affiliation><nlm:aff id="A37">Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="White, Charles L" sort="White, Charles L" uniqKey="White C" first="Charles L." last="White">Charles L. White</name><affiliation><nlm:aff id="A32">Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Wisniewski, Thomas" sort="Wisniewski, Thomas" uniqKey="Wisniewski T" first="Thomas" last="Wisniewski">Thomas Wisniewski</name><affiliation><nlm:aff id="A61">Department of Neurology, Center for Cognitive Neurology, New York University School of Medicine, ERSP, 450 East 29th Street, New York, NY 10016, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A62">Department of Pathology, Center for Cognitive Neurology, New York University School of Medicine, ERSP, 450 East 29th Street, New York, NY 10016, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A63">Department of Psychiatry, Center for Cognitive Neurology, New York University School of Medicine, ERSP, 450 East 29th Street, New York, NY 10016, USA</nlm:aff></affiliation></author><author><name sortKey="Woulfe, John M" sort="Woulfe, John M" uniqKey="Woulfe J" first="John M." last="Woulfe">John M. Woulfe</name><affiliation><nlm:aff id="A64">Department of Pathology and Laboratory Medicine, Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada</nlm:aff></affiliation></author><author><name sortKey="Yamada, Masahito" sort="Yamada, Masahito" uniqKey="Yamada M" first="Masahito" last="Yamada">Masahito Yamada</name><affiliation><nlm:aff id="A65">Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan</nlm:aff></affiliation></author><author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W." last="Dickson">Dennis W. Dickson</name><affiliation><nlm:aff id="A17">Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26659578</idno><idno type="pmc">4879001</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879001</idno><idno type="RBID">PMC:4879001</idno><idno type="doi">10.1007/s00401-015-1509-x</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001D43</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001D43</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy</title><author><name sortKey="Kovacs, Gabor G" sort="Kovacs, Gabor G" uniqKey="Kovacs G" first="Gabor G." last="Kovacs">Gabor G. Kovacs</name><affiliation><nlm:aff id="A1">Institute of Neurology, Medical University of Vienna, AKH 4J, Währinger Gürtel 18-20, 1097 Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Ferrer, Isidro" sort="Ferrer, Isidro" uniqKey="Ferrer I" first="Isidro" last="Ferrer">Isidro Ferrer</name><affiliation><nlm:aff id="A2">Institute of Neuropathology, Bellvitge University Hospital, University of Barcelona, Hospitalet de Llobregat, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Grinberg, Lea T" sort="Grinberg, Lea T" uniqKey="Grinberg L" first="Lea T." last="Grinberg">Lea T. Grinberg</name><affiliation><nlm:aff id="A3">Department of Neurology, Memory and Aging Center, University of California, San Francisco, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Pathology, LIM-22, University of Sao Paulo Medical School, Sao Paulo, Brazil</nlm:aff></affiliation></author><author><name sortKey="Alafuzoff, Irina" sort="Alafuzoff, Irina" uniqKey="Alafuzoff I" first="Irina" last="Alafuzoff">Irina Alafuzoff</name><affiliation><nlm:aff id="A5">Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Attems, Johannes" sort="Attems, Johannes" uniqKey="Attems J" first="Johannes" last="Attems">Johannes Attems</name><affiliation><nlm:aff id="A6">Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK</nlm:aff></affiliation></author><author><name sortKey="Budka, Herbert" sort="Budka, Herbert" uniqKey="Budka H" first="Herbert" last="Budka">Herbert Budka</name><affiliation><nlm:aff id="A7">Institute of Neuropathology, University Hospital Zürich, Zurich, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Cairns, Nigel J" sort="Cairns, Nigel J" uniqKey="Cairns N" first="Nigel J." last="Cairns">Nigel J. Cairns</name><affiliation><nlm:aff id="A8">Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA</nlm:aff></affiliation></author><author><name sortKey="Crary, John F" sort="Crary, John F" uniqKey="Crary J" first="John F." last="Crary">John F. Crary</name><affiliation><nlm:aff id="A9">Department of Pathology, Friedman Brain Institute, and the Ronald M. Loeb Center for Alzheimer’s Disease, Icahn School of Medicine at Mount Sinai, New York, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Fishberg Department of Neuroscience, Friedman Brain Institute, and Ronald M. Loeb Center for Alzheimer’s Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</nlm:aff></affiliation></author><author><name sortKey="Duyckaerts, Charles" sort="Duyckaerts, Charles" uniqKey="Duyckaerts C" first="Charles" last="Duyckaerts">Charles Duyckaerts</name><affiliation><nlm:aff id="A10">Neuropathology Department, Hopital de La Salpetrière, AP-HP, UPMC-Sorbonne-University, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Ghetti, Bernardino" sort="Ghetti, Bernardino" uniqKey="Ghetti B" first="Bernardino" last="Ghetti">Bernardino Ghetti</name><affiliation><nlm:aff id="A11">Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA</nlm:aff></affiliation></author><author><name sortKey="Halliday, Glenda M" sort="Halliday, Glenda M" uniqKey="Halliday G" first="Glenda M." last="Halliday">Glenda M. Halliday</name><affiliation><nlm:aff id="A12">GMH-Neuroscience Research Australia and the University of New South Wales, Sydney, NSW, Australia</nlm:aff></affiliation></author><author><name sortKey="Ironside, James W" sort="Ironside, James W" uniqKey="Ironside J" first="James W." last="Ironside">James W. Ironside</name><affiliation><nlm:aff id="A13">Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Love, Seth" sort="Love, Seth" uniqKey="Love S" first="Seth" last="Love">Seth Love</name><affiliation><nlm:aff id="A14">Institute of Clinical Neurosciences, University of Bristol, Learning and Research Level 2, Southmead Hospital, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Mackenzie, Ian R" sort="Mackenzie, Ian R" uniqKey="Mackenzie I" first="Ian R." last="Mackenzie">Ian R. Mackenzie</name><affiliation><nlm:aff id="A15">Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada</nlm:aff></affiliation></author><author><name sortKey="Munoz, David G" sort="Munoz, David G" uniqKey="Munoz D" first="David G." last="Munoz">David G. Munoz</name><affiliation><nlm:aff id="A16">Division of Pathology, St. Michael’s Hospital, 30 Bond St, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Murray, Melissa E" sort="Murray, Melissa E" uniqKey="Murray M" first="Melissa E." last="Murray">Melissa E. Murray</name><affiliation><nlm:aff id="A17">Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA</nlm:aff></affiliation></author><author><name sortKey="Nelson, Peter T" sort="Nelson, Peter T" uniqKey="Nelson P" first="Peter T." last="Nelson">Peter T. Nelson</name><affiliation><nlm:aff id="A18">Department of Pathology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA</nlm:aff></affiliation></author><author><name sortKey="Takahashi, Hitoshi" sort="Takahashi, Hitoshi" uniqKey="Takahashi H" first="Hitoshi" last="Takahashi">Hitoshi Takahashi</name><affiliation><nlm:aff id="A19">Department of Pathology, Brain Research Institute, Niigata University, Niigata 951-8585, Japan</nlm:aff></affiliation></author><author><name sortKey="Trojanowski, John Q" sort="Trojanowski, John Q" uniqKey="Trojanowski J" first="John Q." last="Trojanowski">John Q. Trojanowski</name><affiliation><nlm:aff id="A20">Department of Pathology and Laboratory Medicine of the Perelman School of Medicine, Center for Neurodegenerative Disease Research, Institute On Aging, University of Pennsylvania, Philadelphia, USA</nlm:aff></affiliation></author><author><name sortKey="Ansorge, Olaf" sort="Ansorge, Olaf" uniqKey="Ansorge O" first="Olaf" last="Ansorge">Olaf Ansorge</name><affiliation><nlm:aff id="A21">Department of Neuropathology, John Radcliffe Hospital, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Arzberger, Thomas" sort="Arzberger, Thomas" uniqKey="Arzberger T" first="Thomas" last="Arzberger">Thomas Arzberger</name><affiliation><nlm:aff id="A22">Department of Psychiatry and Psychotherapy, Centre for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Baborie, Atik" sort="Baborie, Atik" uniqKey="Baborie A" first="Atik" last="Baborie">Atik Baborie</name><affiliation><nlm:aff id="A23">Department of Neuropathology, Walton Centre, Liverpool, UK</nlm:aff></affiliation></author><author><name sortKey="Beach, Thomas G" sort="Beach, Thomas G" uniqKey="Beach T" first="Thomas G." last="Beach">Thomas G. Beach</name><affiliation><nlm:aff id="A24">Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ 85351, USA</nlm:aff></affiliation></author><author><name sortKey="Bieniek, Kevin F" sort="Bieniek, Kevin F" uniqKey="Bieniek K" first="Kevin F." last="Bieniek">Kevin F. Bieniek</name><affiliation><nlm:aff id="A17">Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA</nlm:aff></affiliation></author><author><name sortKey="Bigio, Eileen H" sort="Bigio, Eileen H" uniqKey="Bigio E" first="Eileen H." last="Bigio">Eileen H. Bigio</name><affiliation><nlm:aff id="A25">Northwestern ADC Neuropathology Core, Northwestern University Feinberg School of Medicine, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Bodi, Istvan" sort="Bodi, Istvan" uniqKey="Bodi I" first="Istvan" last="Bodi">Istvan Bodi</name><affiliation><nlm:aff id="A26">Clinical Neuropathology, King’s College Hospital, London Neurodegenerative Brain Bank, London, UK</nlm:aff></affiliation></author><author><name sortKey="Dugger, Brittany N" sort="Dugger, Brittany N" uniqKey="Dugger B" first="Brittany N." last="Dugger">Brittany N. Dugger</name><affiliation><nlm:aff id="A24">Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ 85351, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Institute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Feany, Mel" sort="Feany, Mel" uniqKey="Feany M" first="Mel" last="Feany">Mel Feany</name><affiliation><nlm:aff id="A28">Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Gelpi, Ellen" sort="Gelpi, Ellen" uniqKey="Gelpi E" first="Ellen" last="Gelpi">Ellen Gelpi</name><affiliation><nlm:aff id="A29">Neurological Tissue Bank of the Biobank-Hospital Clinic-IDIBAPS, Institut d’Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Gentleman, Stephen M" sort="Gentleman, Stephen M" uniqKey="Gentleman S" first="Stephen M." last="Gentleman">Stephen M. Gentleman</name><affiliation><nlm:aff id="A30">Department of Medicine, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Giaccone, Giorgio" sort="Giaccone, Giorgio" uniqKey="Giaccone G" first="Giorgio" last="Giaccone">Giorgio Giaccone</name><affiliation><nlm:aff id="A31">IRCCS Foundation “Carlo Besta” Neurological Institute, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Hatanpaa, Kimmo J" sort="Hatanpaa, Kimmo J" uniqKey="Hatanpaa K" first="Kimmo J." last="Hatanpaa">Kimmo J. Hatanpaa</name><affiliation><nlm:aff id="A32">Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Heale, Richard" sort="Heale, Richard" uniqKey="Heale R" first="Richard" last="Heale">Richard Heale</name><affiliation><nlm:aff id="A6">Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK</nlm:aff></affiliation></author><author><name sortKey="Hof, Patrick R" sort="Hof, Patrick R" uniqKey="Hof P" first="Patrick R." last="Hof">Patrick R. Hof</name><affiliation><nlm:aff id="A33">Fishberg Department of Neuroscience, Friedman Brain Institute, and Ronald M. Loeb Center for Alzheimer’s Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</nlm:aff></affiliation></author><author><name sortKey="Hofer, Monika" sort="Hofer, Monika" uniqKey="Hofer M" first="Monika" last="Hofer">Monika Hofer</name><affiliation><nlm:aff id="A21">Department of Neuropathology, John Radcliffe Hospital, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Hortobagyi, Tibor" sort="Hortobagyi, Tibor" uniqKey="Hortobagyi T" first="Tibor" last="Hortobágyi">Tibor Hortobágyi</name><affiliation><nlm:aff id="A34">Department of Neuropathology, Faculty of Medicine, Institute of Pathology, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary</nlm:aff></affiliation></author><author><name sortKey="Jellinger, Kurt" sort="Jellinger, Kurt" uniqKey="Jellinger K" first="Kurt" last="Jellinger">Kurt Jellinger</name><affiliation><nlm:aff id="A35">Institute of Clinical Neurobiology, Alberichgasse 5/13, 1150 Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Jicha, Gregory A" sort="Jicha, Gregory A" uniqKey="Jicha G" first="Gregory A." last="Jicha">Gregory A. Jicha</name><affiliation><nlm:aff id="A36">Department of Neurology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA</nlm:aff></affiliation></author><author><name sortKey="Ince, Paul" sort="Ince, Paul" uniqKey="Ince P" first="Paul" last="Ince">Paul Ince</name><affiliation><nlm:aff id="A37">Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Kofler, Julia" sort="Kofler, Julia" uniqKey="Kofler J" first="Julia" last="Kofler">Julia Kofler</name><affiliation><nlm:aff id="A38">Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Kovari, Eniko" sort="Kovari, Eniko" uniqKey="Kovari E" first="Enikö" last="Kövari">Enikö Kövari</name><affiliation><nlm:aff id="A39">Department of Mental Health and Psychiatry, University Hospitals and University of Geneva School of Medicine, Geneva, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Kril, Jillian J" sort="Kril, Jillian J" uniqKey="Kril J" first="Jillian J." last="Kril">Jillian J. Kril</name><affiliation><nlm:aff id="A40">Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia</nlm:aff></affiliation></author><author><name sortKey="Mann, David M" sort="Mann, David M" uniqKey="Mann D" first="David M." last="Mann">David M. Mann</name><affiliation><nlm:aff id="A41">Institute of Brain, Behaviour and Mental Health, Manchester University Faculty of Medical and Health Sciences, Manchester, UK</nlm:aff></affiliation></author><author><name sortKey="Matej, Radoslav" sort="Matej, Radoslav" uniqKey="Matej R" first="Radoslav" last="Matej">Radoslav Matej</name><affiliation><nlm:aff id="A42">Department of Pathology and Molecular Medicine, Thomayer Hospital, Prague 4, Czech Republic</nlm:aff></affiliation></author><author><name sortKey="Mckee, Ann C" sort="Mckee, Ann C" uniqKey="Mckee A" first="Ann C." last="Mckee">Ann C. Mckee</name><affiliation><nlm:aff id="A43">Department of Neurology and Pathology, Boston University School of Medicine and VA Healthcare System, Boston, MA 02118, USA</nlm:aff></affiliation></author><author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name><affiliation><nlm:aff id="A44">Department of Anatomical Pathology, Alfred Hospital, Prahran, VIC 3004, Australia</nlm:aff></affiliation></author><author><name sortKey="Milenkovic, Ivan" sort="Milenkovic, Ivan" uniqKey="Milenkovic I" first="Ivan" last="Milenkovic">Ivan Milenkovic</name><affiliation><nlm:aff id="A1">Institute of Neurology, Medical University of Vienna, AKH 4J, Währinger Gürtel 18-20, 1097 Vienna, Austria</nlm:aff></affiliation><affiliation><nlm:aff id="A45">Department of Neurology, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas J." last="Montine">Thomas J. Montine</name><affiliation><nlm:aff id="A46">Department of Pathology, University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Murayama, Shigeo" sort="Murayama, Shigeo" uniqKey="Murayama S" first="Shigeo" last="Murayama">Shigeo Murayama</name><affiliation><nlm:aff id="A47">Department of Neuropathology (The Brain Bank for Aging Research), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Lee, Edward B" sort="Lee, Edward B" uniqKey="Lee E" first="Edward B." last="Lee">Edward B. Lee</name><affiliation><nlm:aff id="A20">Department of Pathology and Laboratory Medicine of the Perelman School of Medicine, Center for Neurodegenerative Disease Research, Institute On Aging, University of Pennsylvania, Philadelphia, USA</nlm:aff></affiliation></author><author><name sortKey="Rahimi, Jasmin" sort="Rahimi, Jasmin" uniqKey="Rahimi J" first="Jasmin" last="Rahimi">Jasmin Rahimi</name><affiliation><nlm:aff id="A1">Institute of Neurology, Medical University of Vienna, AKH 4J, Währinger Gürtel 18-20, 1097 Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Rodriguez, Roberta D" sort="Rodriguez, Roberta D" uniqKey="Rodriguez R" first="Roberta D." last="Rodriguez">Roberta D. Rodriguez</name><affiliation><nlm:aff id="A48">Physiopathology in Aging Lab/Brazilian Aging Brain Study Group-LIM22, University of Sao Paulo Medical School, Sao Paulo, Brazil</nlm:aff></affiliation></author><author><name sortKey="Rozemuller, Annemieke" sort="Rozemuller, Annemieke" uniqKey="Rozemuller A" first="Annemieke" last="Rozemüller">Annemieke Rozemüller</name><affiliation><nlm:aff id="A49">Netherlands Brainbank and Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Schneider, Julie A" sort="Schneider, Julie A" uniqKey="Schneider J" first="Julie A." last="Schneider">Julie A. Schneider</name><affiliation><nlm:aff id="A50">Department of Pathology, Rush University Medical Center, Chicago, IL, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A51">Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Schultz, Christian" sort="Schultz, Christian" uniqKey="Schultz C" first="Christian" last="Schultz">Christian Schultz</name><affiliation><nlm:aff id="A52">Institute of Neuroanatomy, Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Seeley, William" sort="Seeley, William" uniqKey="Seeley W" first="William" last="Seeley">William Seeley</name><affiliation><nlm:aff id="A3">Department of Neurology, Memory and Aging Center, University of California, San Francisco, USA</nlm:aff></affiliation></author><author><name sortKey="Seilhean, Danielle" sort="Seilhean, Danielle" uniqKey="Seilhean D" first="Danielle" last="Seilhean">Danielle Seilhean</name><affiliation><nlm:aff id="A10">Neuropathology Department, Hopital de La Salpetrière, AP-HP, UPMC-Sorbonne-University, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Smith, Colin" sort="Smith, Colin" uniqKey="Smith C" first="Colin" last="Smith">Colin Smith</name><affiliation><nlm:aff id="A13">Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Tagliavini, Fabrizio" sort="Tagliavini, Fabrizio" uniqKey="Tagliavini F" first="Fabrizio" last="Tagliavini">Fabrizio Tagliavini</name><affiliation><nlm:aff id="A31">IRCCS Foundation “Carlo Besta” Neurological Institute, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Takao, Masaki" sort="Takao, Masaki" uniqKey="Takao M" first="Masaki" last="Takao">Masaki Takao</name><affiliation><nlm:aff id="A53">Department of Neurology, Saitama Medical University International Medical Center, Saitama, Japan</nlm:aff></affiliation></author><author><name sortKey="Thal, Dietmar Rudolf" sort="Thal, Dietmar Rudolf" uniqKey="Thal D" first="Dietmar Rudolf" last="Thal">Dietmar Rudolf Thal</name><affiliation><nlm:aff id="A54">Laboratory of Neuropathology, Institute of Pathology, University of Ulm, 89081 Ulm, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Department of Neuroscience, KU-Leuven, 3000 Louvain, Belgium</nlm:aff></affiliation></author><author><name sortKey="Toledo, Jon B" sort="Toledo, Jon B" uniqKey="Toledo J" first="Jon B." last="Toledo">Jon B. Toledo</name><affiliation><nlm:aff id="A20">Department of Pathology and Laboratory Medicine of the Perelman School of Medicine, Center for Neurodegenerative Disease Research, Institute On Aging, University of Pennsylvania, Philadelphia, USA</nlm:aff></affiliation></author><author><name sortKey="Tolnay, Markus" sort="Tolnay, Markus" uniqKey="Tolnay M" first="Markus" last="Tolnay">Markus Tolnay</name><affiliation><nlm:aff id="A56">Institute of Pathology, University Hospital Basel, Basel, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Troncoso, Juan C" sort="Troncoso, Juan C" uniqKey="Troncoso J" first="Juan C." last="Troncoso">Juan C. Troncoso</name><affiliation><nlm:aff id="A57">Division of Neuropathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Vinters, Harry V" sort="Vinters, Harry V" uniqKey="Vinters H" first="Harry V." last="Vinters">Harry V. Vinters</name><affiliation><nlm:aff id="A58">Section of Neuropathology, Department of Pathology and Laboratory Medicine, Brain Research Institute, University of California, Los Angeles (UCLA) Medical Center and David Geffen School of Medicine, Los Angeles, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A59">Department of Neurology, Brain Research Institute, University of California, Los Angeles (UCLA) Medical Center and David Geffen School of Medicine, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Weis, Serge" sort="Weis, Serge" uniqKey="Weis S" first="Serge" last="Weis">Serge Weis</name><affiliation><nlm:aff id="A60">Department of Pathology and Neuropathology, Laboratory of Neuropathology, Neuromed Campus, Kepler University Hospital, Medical School, Johannes Kepler University, Linz, Austria</nlm:aff></affiliation></author><author><name sortKey="Wharton, Stephen B" sort="Wharton, Stephen B" uniqKey="Wharton S" first="Stephen B." last="Wharton">Stephen B. Wharton</name><affiliation><nlm:aff id="A37">Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="White, Charles L" sort="White, Charles L" uniqKey="White C" first="Charles L." last="White">Charles L. White</name><affiliation><nlm:aff id="A32">Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Wisniewski, Thomas" sort="Wisniewski, Thomas" uniqKey="Wisniewski T" first="Thomas" last="Wisniewski">Thomas Wisniewski</name><affiliation><nlm:aff id="A61">Department of Neurology, Center for Cognitive Neurology, New York University School of Medicine, ERSP, 450 East 29th Street, New York, NY 10016, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A62">Department of Pathology, Center for Cognitive Neurology, New York University School of Medicine, ERSP, 450 East 29th Street, New York, NY 10016, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A63">Department of Psychiatry, Center for Cognitive Neurology, New York University School of Medicine, ERSP, 450 East 29th Street, New York, NY 10016, USA</nlm:aff></affiliation></author><author><name sortKey="Woulfe, John M" sort="Woulfe, John M" uniqKey="Woulfe J" first="John M." last="Woulfe">John M. Woulfe</name><affiliation><nlm:aff id="A64">Department of Pathology and Laboratory Medicine, Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada</nlm:aff></affiliation></author><author><name sortKey="Yamada, Masahito" sort="Yamada, Masahito" uniqKey="Yamada M" first="Masahito" last="Yamada">Masahito Yamada</name><affiliation><nlm:aff id="A65">Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan</nlm:aff></affiliation></author><author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W." last="Dickson">Dennis W. Dickson</name><affiliation><nlm:aff id="A17">Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Acta neuropathologica</title><idno type="ISSN">0001-6322</idno><idno type="eISSN">1432-0533</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Pathological accumulation of abnormally phosphorylated tau protein in astrocytes is a frequent, but poorly characterized feature of the aging brain. Its etiology is uncertain, but its presence is sufficiently ubiquitous to merit further characterization and classification, which may stimulate clinicopathological studies and research into its pathobiology. This paper aims to harmonize evaluation and nomenclature of aging-related tau astrogliopathy (ARTAG), a term that refers to a morphological spectrum of astroglial pathology detected by tau immunohistochemistry, especially with phosphorylation-dependent and 4R isoform-specific antibodies. ARTAG occurs mainly, but not exclusively, in individuals over 60 years of age. Tau-immunoreactive astrocytes in ARTAG include thorn-shaped astrocytes at the glia limitans and in white matter, as well as solitary or clustered astrocytes with perinuclear cytoplasmic tau immunoreactivity that extends into the astroglial processes as fine fibrillar or granular immunopositivity, typically in gray matter. Various forms of ARTAG may coexist in the same brain and might reflect different pathogenic processes. Based on morphology and anatomical distribution, ARTAG can be distinguished from primary tauopathies, but may be concurrent with primary tauopathies or other disorders. We recommend four steps for evaluation of ARTAG: (1) identification of five types based on the location of either morphologies of tau astrogliopathy: subpial, subependymal, perivascular, white matter, gray matter; (2) documentation of the regional involvement: medial temporal lobe, lobar (frontal, parietal, occipital, lateral temporal), subcortical, brainstem; (3) documentation of the severity of tau astrogliopathy; and (4) description of subregional involvement. Some types of ARTAG may underlie neurological symptoms; however, the clinical significance of ARTAG is currently uncertain and awaits further studies. The goal of this proposal is to raise awareness of astroglial tau pathology in the aged brain, facilitating communication among neuropathologists and researchers, and informing interpretation of clinical biomarkers and imaging studies that focus on tau-related indicators.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0412041</journal-id><journal-id journal-id-type="pubmed-jr-id">133</journal-id><journal-id journal-id-type="nlm-ta">Acta Neuropathol</journal-id><journal-id journal-id-type="iso-abbrev">Acta Neuropathol.</journal-id><journal-title-group><journal-title>Acta neuropathologica</journal-title></journal-title-group><issn pub-type="ppub">0001-6322</issn><issn pub-type="epub">1432-0533</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26659578</article-id><article-id pub-id-type="pmc">4879001</article-id><article-id pub-id-type="doi">10.1007/s00401-015-1509-x</article-id><article-id pub-id-type="manuscript">NIHMS785597</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Kovacs</surname><given-names>Gabor G.</given-names></name><xref ref-type="aff" rid="A1">1</xref><email>gabor.kovacs@meduniwien.ac.at</email></contrib><contrib contrib-type="author"><name><surname>Ferrer</surname><given-names>Isidro</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Grinberg</surname><given-names>Lea T.</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Alafuzoff</surname><given-names>Irina</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Attems</surname><given-names>Johannes</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Budka</surname><given-names>Herbert</given-names></name><xref ref-type="aff" 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contrib-type="author"><name><surname>Seeley</surname><given-names>William</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Seilhean</surname><given-names>Danielle</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Smith</surname><given-names>Colin</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Tagliavini</surname><given-names>Fabrizio</given-names></name><xref ref-type="aff" rid="A31">31</xref></contrib><contrib contrib-type="author"><name><surname>Takao</surname><given-names>Masaki</given-names></name><xref ref-type="aff" rid="A53">53</xref></contrib><contrib contrib-type="author"><name><surname>Thal</surname><given-names>Dietmar Rudolf</given-names></name><xref ref-type="aff" rid="A54">54</xref><xref ref-type="aff" rid="A55">55</xref></contrib><contrib contrib-type="author"><name><surname>Toledo</surname><given-names>Jon B.</given-names></name><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Tolnay</surname><given-names>Markus</given-names></name><xref ref-type="aff" rid="A56">56</xref></contrib><contrib contrib-type="author"><name><surname>Troncoso</surname><given-names>Juan C.</given-names></name><xref ref-type="aff" rid="A57">57</xref></contrib><contrib contrib-type="author"><name><surname>Vinters</surname><given-names>Harry V.</given-names></name><xref ref-type="aff" rid="A58">58</xref><xref ref-type="aff" rid="A59">59</xref></contrib><contrib contrib-type="author"><name><surname>Weis</surname><given-names>Serge</given-names></name><xref ref-type="aff" rid="A60">60</xref></contrib><contrib contrib-type="author"><name><surname>Wharton</surname><given-names>Stephen B.</given-names></name><xref ref-type="aff" rid="A37">37</xref></contrib><contrib contrib-type="author"><name><surname>White</surname><given-names>Charles L.</given-names><suffix>III</suffix></name><xref ref-type="aff" rid="A32">32</xref></contrib><contrib contrib-type="author"><name><surname>Wisniewski</surname><given-names>Thomas</given-names></name><xref ref-type="aff" rid="A61">61</xref><xref ref-type="aff" rid="A62">62</xref><xref ref-type="aff" rid="A63">63</xref></contrib><contrib contrib-type="author"><name><surname>Woulfe</surname><given-names>John M.</given-names></name><xref ref-type="aff" rid="A64">64</xref></contrib><contrib contrib-type="author"><name><surname>Yamada</surname><given-names>Masahito</given-names></name><xref ref-type="aff" rid="A65">65</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Dickson</surname><given-names>Dennis W.</given-names></name><xref ref-type="aff" rid="A17">17</xref><email>dickson.dennis@mayo.edu</email></contrib></contrib-group><aff id="A1"><label>1</label>Institute of Neurology, Medical University of Vienna, AKH 4J, Währinger Gürtel 18-20, 1097 Vienna, Austria</aff><aff id="A2"><label>2</label>Institute of Neuropathology, Bellvitge University Hospital, University of Barcelona, Hospitalet de Llobregat, Barcelona, Spain</aff><aff id="A3"><label>3</label>Department of Neurology, Memory and Aging Center, University of California, San Francisco, USA</aff><aff id="A4"><label>4</label>Department of Pathology, LIM-22, University of Sao Paulo Medical School, Sao Paulo, Brazil</aff><aff id="A5"><label>5</label>Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden</aff><aff id="A6"><label>6</label>Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK</aff><aff id="A7"><label>7</label>Institute of Neuropathology, University Hospital Zürich, Zurich, Switzerland</aff><aff id="A8"><label>8</label>Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA</aff><aff id="A9"><label>9</label>Department of Pathology, Friedman Brain Institute, and the Ronald M. Loeb Center for Alzheimer’s Disease, Icahn School of Medicine at Mount Sinai, New York, USA</aff><aff id="A10"><label>10</label>Neuropathology Department, Hopital de La Salpetrière, AP-HP, UPMC-Sorbonne-University, Paris, France</aff><aff id="A11"><label>11</label>Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA</aff><aff id="A12"><label>12</label>GMH-Neuroscience Research Australia and the University of New South Wales, Sydney, NSW, Australia</aff><aff id="A13"><label>13</label>Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK</aff><aff id="A14"><label>14</label>Institute of Clinical Neurosciences, University of Bristol, Learning and Research Level 2, Southmead Hospital, Bristol, UK</aff><aff id="A15"><label>15</label>Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada</aff><aff id="A16"><label>16</label>Division of Pathology, St. Michael’s Hospital, 30 Bond St, Toronto, ON, Canada</aff><aff id="A17"><label>17</label>Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA</aff><aff id="A18"><label>18</label>Department of Pathology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA</aff><aff id="A19"><label>19</label>Department of Pathology, Brain Research Institute, Niigata University, Niigata 951-8585, Japan</aff><aff id="A20"><label>20</label>Department of Pathology and Laboratory Medicine of the Perelman School of Medicine, Center for Neurodegenerative Disease Research, Institute On Aging, University of Pennsylvania, Philadelphia, USA</aff><aff id="A21"><label>21</label>Department of Neuropathology, John Radcliffe Hospital, Oxford, UK</aff><aff id="A22"><label>22</label>Department of Psychiatry and Psychotherapy, Centre for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, Munich, Germany</aff><aff id="A23"><label>23</label>Department of Neuropathology, Walton Centre, Liverpool, UK</aff><aff id="A24"><label>24</label>Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ 85351, USA</aff><aff id="A25"><label>25</label>Northwestern ADC Neuropathology Core, Northwestern University Feinberg School of Medicine, Chicago, IL, USA</aff><aff id="A26"><label>26</label>Clinical Neuropathology, King’s College Hospital, London Neurodegenerative Brain Bank, London, UK</aff><aff id="A27"><label>27</label>Institute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, CA, USA</aff><aff id="A28"><label>28</label>Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA</aff><aff id="A29"><label>29</label>Neurological Tissue Bank of the Biobank-Hospital Clinic-IDIBAPS, Institut d’Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain</aff><aff id="A30"><label>30</label>Department of Medicine, Imperial College London, London, UK</aff><aff id="A31"><label>31</label>IRCCS Foundation “Carlo Besta” Neurological Institute, Milan, Italy</aff><aff id="A32"><label>32</label>Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA</aff><aff id="A33"><label>33</label>Fishberg Department of Neuroscience, Friedman Brain Institute, and Ronald M. Loeb Center for Alzheimer’s Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</aff><aff id="A34"><label>34</label>Department of Neuropathology, Faculty of Medicine, Institute of Pathology, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary</aff><aff id="A35"><label>35</label>Institute of Clinical Neurobiology, Alberichgasse 5/13, 1150 Vienna, Austria</aff><aff id="A36"><label>36</label>Department of Neurology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA</aff><aff id="A37"><label>37</label>Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK</aff><aff id="A38"><label>38</label>Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA</aff><aff id="A39"><label>39</label>Department of Mental Health and Psychiatry, University Hospitals and University of Geneva School of Medicine, Geneva, Switzerland</aff><aff id="A40"><label>40</label>Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia</aff><aff id="A41"><label>41</label>Institute of Brain, Behaviour and Mental Health, Manchester University Faculty of Medical and Health Sciences, Manchester, UK</aff><aff id="A42"><label>42</label>Department of Pathology and Molecular Medicine, Thomayer Hospital, Prague 4, Czech Republic</aff><aff id="A43"><label>43</label>Department of Neurology and Pathology, Boston University School of Medicine and VA Healthcare System, Boston, MA 02118, USA</aff><aff id="A44"><label>44</label>Department of Anatomical Pathology, Alfred Hospital, Prahran, VIC 3004, Australia</aff><aff id="A45"><label>45</label>Department of Neurology, Medical University of Vienna, Vienna, Austria</aff><aff id="A46"><label>46</label>Department of Pathology, University of Washington, Seattle, WA, USA</aff><aff id="A47"><label>47</label>Department of Neuropathology (The Brain Bank for Aging Research), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan</aff><aff id="A48"><label>48</label>Physiopathology in Aging Lab/Brazilian Aging Brain Study Group-LIM22, University of Sao Paulo Medical School, Sao Paulo, Brazil</aff><aff id="A49"><label>49</label>Netherlands Brainbank and Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands</aff><aff id="A50"><label>50</label>Department of Pathology, Rush University Medical Center, Chicago, IL, USA</aff><aff id="A51"><label>51</label>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA</aff><aff id="A52"><label>52</label>Institute of Neuroanatomy, Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany</aff><aff id="A53"><label>53</label>Department of Neurology, Saitama Medical University International Medical Center, Saitama, Japan</aff><aff id="A54"><label>54</label>Laboratory of Neuropathology, Institute of Pathology, University of Ulm, 89081 Ulm, Germany</aff><aff id="A55"><label>55</label>Department of Neuroscience, KU-Leuven, 3000 Louvain, Belgium</aff><aff id="A56"><label>56</label>Institute of Pathology, University Hospital Basel, Basel, Switzerland</aff><aff id="A57"><label>57</label>Division of Neuropathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA</aff><aff id="A58"><label>58</label>Section of Neuropathology, Department of Pathology and Laboratory Medicine, Brain Research Institute, University of California, Los Angeles (UCLA) Medical Center and David Geffen School of Medicine, Los Angeles, CA, USA</aff><aff id="A59"><label>59</label>Department of Neurology, Brain Research Institute, University of California, Los Angeles (UCLA) Medical Center and David Geffen School of Medicine, Los Angeles, CA, USA</aff><aff id="A60"><label>60</label>Department of Pathology and Neuropathology, Laboratory of Neuropathology, Neuromed Campus, Kepler University Hospital, Medical School, Johannes Kepler University, Linz, Austria</aff><aff id="A61"><label>61</label>Department of Neurology, Center for Cognitive Neurology, New York University School of Medicine, ERSP, 450 East 29th Street, New York, NY 10016, USA</aff><aff id="A62"><label>62</label>Department of Pathology, Center for Cognitive Neurology, New York University School of Medicine, ERSP, 450 East 29th Street, New York, NY 10016, USA</aff><aff id="A63"><label>63</label>Department of Psychiatry, Center for Cognitive Neurology, New York University School of Medicine, ERSP, 450 East 29th Street, New York, NY 10016, USA</aff><aff id="A64"><label>64</label>Department of Pathology and Laboratory Medicine, Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada</aff><aff id="A65"><label>65</label>Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan</aff><pub-date pub-type="nihms-submitted"><day>13</day><month>5</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>10</day><month>12</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>1</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>1</month><year>2017</year></pub-date><volume>131</volume><issue>1</issue><fpage>87</fpage><lpage>102</lpage><pmc-comment>elocation-id from pubmed: 10.1007/s00401-015-1509-x</pmc-comment>
<abstract><p id="P1">Pathological accumulation of abnormally phosphorylated tau protein in astrocytes is a frequent, but poorly characterized feature of the aging brain. Its etiology is uncertain, but its presence is sufficiently ubiquitous to merit further characterization and classification, which may stimulate clinicopathological studies and research into its pathobiology. This paper aims to harmonize evaluation and nomenclature of aging-related tau astrogliopathy (ARTAG), a term that refers to a morphological spectrum of astroglial pathology detected by tau immunohistochemistry, especially with phosphorylation-dependent and 4R isoform-specific antibodies. ARTAG occurs mainly, but not exclusively, in individuals over 60 years of age. Tau-immunoreactive astrocytes in ARTAG include thorn-shaped astrocytes at the glia limitans and in white matter, as well as solitary or clustered astrocytes with perinuclear cytoplasmic tau immunoreactivity that extends into the astroglial processes as fine fibrillar or granular immunopositivity, typically in gray matter. Various forms of ARTAG may coexist in the same brain and might reflect different pathogenic processes. Based on morphology and anatomical distribution, ARTAG can be distinguished from primary tauopathies, but may be concurrent with primary tauopathies or other disorders. We recommend four steps for evaluation of ARTAG: (1) identification of five types based on the location of either morphologies of tau astrogliopathy: subpial, subependymal, perivascular, white matter, gray matter; (2) documentation of the regional involvement: medial temporal lobe, lobar (frontal, parietal, occipital, lateral temporal), subcortical, brainstem; (3) documentation of the severity of tau astrogliopathy; and (4) description of subregional involvement. Some types of ARTAG may underlie neurological symptoms; however, the clinical significance of ARTAG is currently uncertain and awaits further studies. The goal of this proposal is to raise awareness of astroglial tau pathology in the aged brain, facilitating communication among neuropathologists and researchers, and informing interpretation of clinical biomarkers and imaging studies that focus on tau-related indicators.</p></abstract><kwd-group><kwd>Aging</kwd><kwd>ARTAG</kwd><kwd>Tau astrogliopathy</kwd><kwd>Tau</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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