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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genome-Wide Association Study Identifies Variants Associated with Progression of Liver Fibrosis from HCV Infection</title><author><name sortKey="Patin, Etienne" sort="Patin, Etienne" uniqKey="Patin E" first="Etienne" last="Patin">Etienne Patin</name><affiliation><nlm:aff id="A1">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, Institut National de la Santé et de la Recherche Médicale (INSERM) U980, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">University Paris Descartes, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltán" last="Kutalik">Zoltán Kutalik</name><affiliation><nlm:aff id="A3">Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Swiss Institute of Bioinformatics, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Guergnon, Julien" sort="Guergnon, Julien" uniqKey="Guergnon J" first="Julien" last="Guergnon">Julien Guergnon</name><affiliation><nlm:aff id="A5">Laboratory of Immunity and Infection, INSERM UMR-S 945, UPMC Université Paris 6, Groupe Hospitalier Pitié-Salpêtrière AP-HP, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Bibert, Stephanie" sort="Bibert, Stephanie" uniqKey="Bibert S" first="Stéphanie" last="Bibert">Stéphanie Bibert</name><affiliation><nlm:aff id="A6">Service of Infectious Diseases, Department of Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Nalpas, Bertrand" sort="Nalpas, Bertrand" uniqKey="Nalpas B" first="Bertrand" last="Nalpas">Bertrand Nalpas</name><affiliation><nlm:aff id="A2">University Paris Descartes, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Département d’Hépatologie, INSERM U1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Jouanguy, Emmanuelle" sort="Jouanguy, Emmanuelle" uniqKey="Jouanguy E" first="Emmanuelle" last="Jouanguy">Emmanuelle Jouanguy</name><affiliation><nlm:aff id="A1">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, Institut National de la Santé et de la Recherche Médicale (INSERM) U980, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">University Paris Descartes, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A8">St; Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Munteanu, Mona" sort="Munteanu, Mona" uniqKey="Munteanu M" first="Mona" last="Munteanu">Mona Munteanu</name><affiliation><nlm:aff id="A9">Biopredictive, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Bousquet, Laurence" sort="Bousquet, Laurence" uniqKey="Bousquet L" first="Laurence" last="Bousquet">Laurence Bousquet</name><affiliation><nlm:aff id="A2">University Paris Descartes, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Département d’Hépatologie, INSERM U1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Argiro, Laurent" sort="Argiro, Laurent" uniqKey="Argiro L" first="Laurent" last="Argiro">Laurent Argiro</name><affiliation><nlm:aff id="A10">Laboratoire d’Immunologie et de Génétique des Maladies Parasitaires, INSERM-UMR 906/Université de la Méditerranée, Marseilles, France</nlm:aff></affiliation></author><author><name sortKey="Halfon, Philippe" sort="Halfon, Philippe" uniqKey="Halfon P" first="Philippe" last="Halfon">Philippe Halfon</name><affiliation><nlm:aff id="A11">Laboratoire Alphabio, Hôpital Ambroise Paré, Marseilles, France</nlm:aff></affiliation></author><author><name sortKey="Boland, Anne" sort="Boland, Anne" uniqKey="Boland A" first="Anne" last="Boland">Anne Boland</name><affiliation><nlm:aff id="A12">CEA, Institut de Génomique, Centre National de Génotypage, Evry, France</nlm:aff></affiliation></author><author><name sortKey="Mullhaupt, Beat" sort="Mullhaupt, Beat" uniqKey="Mullhaupt B" first="Beat" last="Müllhaupt">Beat Müllhaupt</name><affiliation><nlm:aff id="A13">Division of Gastroenterology and Hepatology, University Hospital, Zurich, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Semela, David" sort="Semela, David" uniqKey="Semela D" first="David" last="Semela">David Semela</name><affiliation><nlm:aff id="A14">Division of Gastroenterology, Canton Hospital, St Gallen, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Dufour, Jean Francois" sort="Dufour, Jean Francois" uniqKey="Dufour J" first="Jean-François" last="Dufour">Jean-François Dufour</name><affiliation><nlm:aff id="A15">Hepatology, Department of Clinical Research, University Clinic for visceral Surgery and Medicine, Bern, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Heim, Markus H" sort="Heim, Markus H" uniqKey="Heim M" first="Markus H." last="Heim">Markus H. Heim</name><affiliation><nlm:aff id="A16">Division of Gastroenterology and Hepatology, University Hospital, Basel, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Moradpour, Darius" sort="Moradpour, Darius" uniqKey="Moradpour D" first="Darius" last="Moradpour">Darius Moradpour</name><affiliation><nlm:aff id="A17">Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Cerny, Andreas" sort="Cerny, Andreas" uniqKey="Cerny A" first="Andreas" last="Cerny">Andreas Cerny</name><affiliation><nlm:aff id="A18">Clinica Moncucco, Lugano, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Malinverni, Raffaele" sort="Malinverni, Raffaele" uniqKey="Malinverni R" first="Raffaele" last="Malinverni">Raffaele Malinverni</name><affiliation><nlm:aff id="A19">Pourtalès Hospital, Neuchâtel, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Hirsch, Hans" sort="Hirsch, Hans" uniqKey="Hirsch H" first="Hans" last="Hirsch">Hans Hirsch</name><affiliation><nlm:aff id="A20">Institute for Medical Microbiology, University Hospital, Basel, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Martinetti, Gladys" sort="Martinetti, Gladys" uniqKey="Martinetti G" first="Gladys" last="Martinetti">Gladys Martinetti</name><affiliation><nlm:aff id="A21">Institute of Medical Microbiology, Bellinzona, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Suppiah, Vijayaprakash" sort="Suppiah, Vijayaprakash" uniqKey="Suppiah V" first="Vijayaprakash" last="Suppiah">Vijayaprakash Suppiah</name><affiliation><nlm:aff id="A22">Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Stewart, Graeme" sort="Stewart, Graeme" uniqKey="Stewart G" first="Graeme" last="Stewart">Graeme Stewart</name><affiliation><nlm:aff id="A23">Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Booth, David R" sort="Booth, David R" uniqKey="Booth D" first="David R." last="Booth">David R. Booth</name><affiliation><nlm:aff id="A23">Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="George, Jacob" sort="George, Jacob" uniqKey="George J" first="Jacob" last="George">Jacob George</name><affiliation><nlm:aff id="A22">Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name><affiliation><nlm:aff id="A1">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, Institut National de la Santé et de la Recherche Médicale (INSERM) U980, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">University Paris Descartes, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A8">St; Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Brechot, Christian" sort="Brechot, Christian" uniqKey="Brechot C" first="Christian" last="Bréchot">Christian Bréchot</name><affiliation><nlm:aff id="A24">INSERM U785, Liver Hepatology Centre, Paul Brousse Hospital, University Paris-XI, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Rice, Charles M" sort="Rice, Charles M" uniqKey="Rice C" first="Charles M." last="Rice">Charles M. Rice</name><affiliation><nlm:aff id="A25">Center for the Study of Hepatitis C, Rockefeller University, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Talal, Andrew H" sort="Talal, Andrew H" uniqKey="Talal A" first="Andrew H." last="Talal">Andrew H. Talal</name><affiliation><nlm:aff id="A26">Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Jacobson, Ira M" sort="Jacobson, Ira M" uniqKey="Jacobson I" first="Ira M." last="Jacobson">Ira M. Jacobson</name><affiliation><nlm:aff id="A26">Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Bourliere, Marc" sort="Bourliere, Marc" uniqKey="Bourliere M" first="Marc" last="Bourlière">Marc Bourlière</name><affiliation><nlm:aff id="A27">Service d’Hépato-gastroentérologie, Hôpital Saint-Joseph, Marseilles, France</nlm:aff></affiliation></author><author><name sortKey="Theodorou, Ioannis" sort="Theodorou, Ioannis" uniqKey="Theodorou I" first="Ioannis" last="Theodorou">Ioannis Theodorou</name><affiliation><nlm:aff id="A5">Laboratory of Immunity and Infection, INSERM UMR-S 945, UPMC Université Paris 6, Groupe Hospitalier Pitié-Salpêtrière AP-HP, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Poynard, Thierry" sort="Poynard, Thierry" uniqKey="Poynard T" first="Thierry" last="Poynard">Thierry Poynard</name><affiliation><nlm:aff id="A28">Université Pierre et Marie Curie, Service d’Hépato-gastroentérologie, Hôpital Pitié-Salpêtrière (AP-HP), Paris, France</nlm:aff></affiliation></author><author><name sortKey="Negro, Francesco" sort="Negro, Francesco" uniqKey="Negro F" first="Francesco" last="Negro">Francesco Negro</name><affiliation><nlm:aff id="A29">Divisions of Gastroenterology and Hepatology and of Clinical Pathology, University Hospital, Geneva, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Pol, Stanislas" sort="Pol, Stanislas" uniqKey="Pol S" first="Stanislas" last="Pol">Stanislas Pol</name><affiliation><nlm:aff id="A2">University Paris Descartes, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Département d’Hépatologie, INSERM U1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Bochud, Pierre Yves" sort="Bochud, Pierre Yves" uniqKey="Bochud P" first="Pierre-Yves" last="Bochud">Pierre-Yves Bochud</name><affiliation><nlm:aff id="A6">Service of Infectious Diseases, Department of Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Abel, Laurent" sort="Abel, Laurent" uniqKey="Abel L" first="Laurent" last="Abel">Laurent Abel</name><affiliation><nlm:aff id="A1">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, Institut National de la Santé et de la Recherche Médicale (INSERM) U980, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">University Paris Descartes, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A8">St; Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22841784</idno><idno type="pmc">3756935</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756935</idno><idno type="RBID">PMC:3756935</idno><idno type="doi">10.1053/j.gastro.2012.07.097</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">001D09</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001D09</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome-Wide Association Study Identifies Variants Associated with Progression of Liver Fibrosis from HCV Infection</title><author><name sortKey="Patin, Etienne" sort="Patin, Etienne" uniqKey="Patin E" first="Etienne" last="Patin">Etienne Patin</name><affiliation><nlm:aff id="A1">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, Institut National de la Santé et de la Recherche Médicale (INSERM) U980, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">University Paris Descartes, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltán" last="Kutalik">Zoltán Kutalik</name><affiliation><nlm:aff id="A3">Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Swiss Institute of Bioinformatics, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Guergnon, Julien" sort="Guergnon, Julien" uniqKey="Guergnon J" first="Julien" last="Guergnon">Julien Guergnon</name><affiliation><nlm:aff id="A5">Laboratory of Immunity and Infection, INSERM UMR-S 945, UPMC Université Paris 6, Groupe Hospitalier Pitié-Salpêtrière AP-HP, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Bibert, Stephanie" sort="Bibert, Stephanie" uniqKey="Bibert S" first="Stéphanie" last="Bibert">Stéphanie Bibert</name><affiliation><nlm:aff id="A6">Service of Infectious Diseases, Department of Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Nalpas, Bertrand" sort="Nalpas, Bertrand" uniqKey="Nalpas B" first="Bertrand" last="Nalpas">Bertrand Nalpas</name><affiliation><nlm:aff id="A2">University Paris Descartes, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Département d’Hépatologie, INSERM U1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Jouanguy, Emmanuelle" sort="Jouanguy, Emmanuelle" uniqKey="Jouanguy E" first="Emmanuelle" last="Jouanguy">Emmanuelle Jouanguy</name><affiliation><nlm:aff id="A1">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, Institut National de la Santé et de la Recherche Médicale (INSERM) U980, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">University Paris Descartes, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A8">St; Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Munteanu, Mona" sort="Munteanu, Mona" uniqKey="Munteanu M" first="Mona" last="Munteanu">Mona Munteanu</name><affiliation><nlm:aff id="A9">Biopredictive, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Bousquet, Laurence" sort="Bousquet, Laurence" uniqKey="Bousquet L" first="Laurence" last="Bousquet">Laurence Bousquet</name><affiliation><nlm:aff id="A2">University Paris Descartes, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Département d’Hépatologie, INSERM U1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Argiro, Laurent" sort="Argiro, Laurent" uniqKey="Argiro L" first="Laurent" last="Argiro">Laurent Argiro</name><affiliation><nlm:aff id="A10">Laboratoire d’Immunologie et de Génétique des Maladies Parasitaires, INSERM-UMR 906/Université de la Méditerranée, Marseilles, France</nlm:aff></affiliation></author><author><name sortKey="Halfon, Philippe" sort="Halfon, Philippe" uniqKey="Halfon P" first="Philippe" last="Halfon">Philippe Halfon</name><affiliation><nlm:aff id="A11">Laboratoire Alphabio, Hôpital Ambroise Paré, Marseilles, France</nlm:aff></affiliation></author><author><name sortKey="Boland, Anne" sort="Boland, Anne" uniqKey="Boland A" first="Anne" last="Boland">Anne Boland</name><affiliation><nlm:aff id="A12">CEA, Institut de Génomique, Centre National de Génotypage, Evry, France</nlm:aff></affiliation></author><author><name sortKey="Mullhaupt, Beat" sort="Mullhaupt, Beat" uniqKey="Mullhaupt B" first="Beat" last="Müllhaupt">Beat Müllhaupt</name><affiliation><nlm:aff id="A13">Division of Gastroenterology and Hepatology, University Hospital, Zurich, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Semela, David" sort="Semela, David" uniqKey="Semela D" first="David" last="Semela">David Semela</name><affiliation><nlm:aff id="A14">Division of Gastroenterology, Canton Hospital, St Gallen, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Dufour, Jean Francois" sort="Dufour, Jean Francois" uniqKey="Dufour J" first="Jean-François" last="Dufour">Jean-François Dufour</name><affiliation><nlm:aff id="A15">Hepatology, Department of Clinical Research, University Clinic for visceral Surgery and Medicine, Bern, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Heim, Markus H" sort="Heim, Markus H" uniqKey="Heim M" first="Markus H." last="Heim">Markus H. Heim</name><affiliation><nlm:aff id="A16">Division of Gastroenterology and Hepatology, University Hospital, Basel, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Moradpour, Darius" sort="Moradpour, Darius" uniqKey="Moradpour D" first="Darius" last="Moradpour">Darius Moradpour</name><affiliation><nlm:aff id="A17">Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Cerny, Andreas" sort="Cerny, Andreas" uniqKey="Cerny A" first="Andreas" last="Cerny">Andreas Cerny</name><affiliation><nlm:aff id="A18">Clinica Moncucco, Lugano, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Malinverni, Raffaele" sort="Malinverni, Raffaele" uniqKey="Malinverni R" first="Raffaele" last="Malinverni">Raffaele Malinverni</name><affiliation><nlm:aff id="A19">Pourtalès Hospital, Neuchâtel, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Hirsch, Hans" sort="Hirsch, Hans" uniqKey="Hirsch H" first="Hans" last="Hirsch">Hans Hirsch</name><affiliation><nlm:aff id="A20">Institute for Medical Microbiology, University Hospital, Basel, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Martinetti, Gladys" sort="Martinetti, Gladys" uniqKey="Martinetti G" first="Gladys" last="Martinetti">Gladys Martinetti</name><affiliation><nlm:aff id="A21">Institute of Medical Microbiology, Bellinzona, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Suppiah, Vijayaprakash" sort="Suppiah, Vijayaprakash" uniqKey="Suppiah V" first="Vijayaprakash" last="Suppiah">Vijayaprakash Suppiah</name><affiliation><nlm:aff id="A22">Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Stewart, Graeme" sort="Stewart, Graeme" uniqKey="Stewart G" first="Graeme" last="Stewart">Graeme Stewart</name><affiliation><nlm:aff id="A23">Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Booth, David R" sort="Booth, David R" uniqKey="Booth D" first="David R." last="Booth">David R. Booth</name><affiliation><nlm:aff id="A23">Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="George, Jacob" sort="George, Jacob" uniqKey="George J" first="Jacob" last="George">Jacob George</name><affiliation><nlm:aff id="A22">Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name><affiliation><nlm:aff id="A1">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, Institut National de la Santé et de la Recherche Médicale (INSERM) U980, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">University Paris Descartes, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A8">St; Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Brechot, Christian" sort="Brechot, Christian" uniqKey="Brechot C" first="Christian" last="Bréchot">Christian Bréchot</name><affiliation><nlm:aff id="A24">INSERM U785, Liver Hepatology Centre, Paul Brousse Hospital, University Paris-XI, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Rice, Charles M" sort="Rice, Charles M" uniqKey="Rice C" first="Charles M." last="Rice">Charles M. Rice</name><affiliation><nlm:aff id="A25">Center for the Study of Hepatitis C, Rockefeller University, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Talal, Andrew H" sort="Talal, Andrew H" uniqKey="Talal A" first="Andrew H." last="Talal">Andrew H. Talal</name><affiliation><nlm:aff id="A26">Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Jacobson, Ira M" sort="Jacobson, Ira M" uniqKey="Jacobson I" first="Ira M." last="Jacobson">Ira M. Jacobson</name><affiliation><nlm:aff id="A26">Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Bourliere, Marc" sort="Bourliere, Marc" uniqKey="Bourliere M" first="Marc" last="Bourlière">Marc Bourlière</name><affiliation><nlm:aff id="A27">Service d’Hépato-gastroentérologie, Hôpital Saint-Joseph, Marseilles, France</nlm:aff></affiliation></author><author><name sortKey="Theodorou, Ioannis" sort="Theodorou, Ioannis" uniqKey="Theodorou I" first="Ioannis" last="Theodorou">Ioannis Theodorou</name><affiliation><nlm:aff id="A5">Laboratory of Immunity and Infection, INSERM UMR-S 945, UPMC Université Paris 6, Groupe Hospitalier Pitié-Salpêtrière AP-HP, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Poynard, Thierry" sort="Poynard, Thierry" uniqKey="Poynard T" first="Thierry" last="Poynard">Thierry Poynard</name><affiliation><nlm:aff id="A28">Université Pierre et Marie Curie, Service d’Hépato-gastroentérologie, Hôpital Pitié-Salpêtrière (AP-HP), Paris, France</nlm:aff></affiliation></author><author><name sortKey="Negro, Francesco" sort="Negro, Francesco" uniqKey="Negro F" first="Francesco" last="Negro">Francesco Negro</name><affiliation><nlm:aff id="A29">Divisions of Gastroenterology and Hepatology and of Clinical Pathology, University Hospital, Geneva, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Pol, Stanislas" sort="Pol, Stanislas" uniqKey="Pol S" first="Stanislas" last="Pol">Stanislas Pol</name><affiliation><nlm:aff id="A2">University Paris Descartes, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Département d’Hépatologie, INSERM U1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Bochud, Pierre Yves" sort="Bochud, Pierre Yves" uniqKey="Bochud P" first="Pierre-Yves" last="Bochud">Pierre-Yves Bochud</name><affiliation><nlm:aff id="A6">Service of Infectious Diseases, Department of Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Abel, Laurent" sort="Abel, Laurent" uniqKey="Abel L" first="Laurent" last="Abel">Laurent Abel</name><affiliation><nlm:aff id="A1">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, Institut National de la Santé et de la Recherche Médicale (INSERM) U980, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">University Paris Descartes, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A8">St; Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Gastroenterology</title><idno type="ISSN">0016-5085</idno><idno type="eISSN">1528-0012</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>BACKGROUND & AIMS</title><p id="P2">Polymorphisms in <italic>IL28B</italic> were shown to affect clearance of hepatitis C virus (HCV) infection in genome-wide association (GWA) studies. Only a fraction of patients with chronic HCV infection develop liver fibrosis, a process that might also be affected by genetic factors. We carried out a 2-stage GWA study of liver fibrosis progression related to HCV infection.</p></sec><sec id="S2"><title>METHODS</title><p id="P3">We studied well-characterized HCV-infected patients of European descent who had liver biopsies before treatment. We defined various liver fibrosis phenotypes on the basis of Metavir scores, with and without taking the duration of HCV infection into account. Our GWA analyses were conducted on a filtered primary cohort of 1161 patients using 780,650 single nucleotide polymorphisms (SNPs). We genotyped 96 SNPs with <italic>P</italic>-values<5×10<sup>−5</sup> from an independent replication cohort of 962 patients. We then assessed the most interesting replicated SNPs using DNA samples collected from 219 patients who participated in separate GWA studies of HCV clearance.</p></sec><sec id="S3"><title>RESULTS</title><p id="P4">In the combined cohort of 2342 HCV-infected patients, the SNPs rs16851720 (in the total sample) and rs4374383 (in patients that received blood transfusions) were associated with fibrosis progression (<italic><sub>Pcombined</sub></italic>=8.9×10<sup>−9</sup> and 1.1×10<sup>−9</sup>, respectively). The SNP rs16851720 is located within <italic>RNF7</italic>, which encodes an antioxidant that protects against apoptosis. The SNP rs4374383, together with another replicated SNP, rs9380516 (<italic>P<sub>combined</sub></italic>=5.4×10<sup>−7</sup>), were linked to the functionally related genes <italic>MERTK</italic> and <italic>TULP1</italic>, which encode factors involved in phagocytosis of apoptotic cells by macrophages.</p></sec><sec id="S4"><title>CONCLUSIONS</title><p id="P5">Our GWA study identified several susceptibility loci for HCV-induced liver fibrosis; these were linked to genes that regulate apoptosis. Apoptotic control might therefore be involved in liver fibrosis.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0374630</journal-id><journal-id journal-id-type="pubmed-jr-id">3841</journal-id><journal-id journal-id-type="nlm-ta">Gastroenterology</journal-id><journal-id journal-id-type="iso-abbrev">Gastroenterology</journal-id><journal-title-group><journal-title>Gastroenterology</journal-title></journal-title-group><issn pub-type="ppub">0016-5085</issn><issn pub-type="epub">1528-0012</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22841784</article-id><article-id pub-id-type="pmc">3756935</article-id><article-id pub-id-type="doi">10.1053/j.gastro.2012.07.097</article-id><article-id pub-id-type="manuscript">NIHMS477303</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Genome-Wide Association Study Identifies Variants Associated with Progression of Liver Fibrosis from HCV Infection</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>PATIN</surname><given-names>ETIENNE</given-names></name><xref ref-type="aff" rid="A1">*</xref><xref ref-type="aff" rid="A2">‡</xref><xref rid="FN2" ref-type="author-notes">§</xref></contrib><contrib contrib-type="author"><name><surname>KUTALIK</surname><given-names>ZOLTÁN</given-names></name><xref ref-type="aff" rid="A3">||</xref><xref ref-type="aff" rid="A4">¶</xref></contrib><contrib contrib-type="author"><name><surname>GUERGNON</surname><given-names>JULIEN</given-names></name><xref ref-type="aff" rid="A5">#</xref></contrib><contrib contrib-type="author"><name><surname>BIBERT</surname><given-names>STÉPHANIE</given-names></name><xref ref-type="aff" rid="A6">**</xref></contrib><contrib contrib-type="author"><name><surname>NALPAS</surname><given-names>BERTRAND</given-names></name><xref ref-type="aff" rid="A2">‡</xref><xref ref-type="aff" rid="A7">‡‡</xref></contrib><contrib contrib-type="author"><name><surname>JOUANGUY</surname><given-names>EMMANUELLE</given-names></name><xref ref-type="aff" rid="A1">*</xref><xref ref-type="aff" rid="A2">‡</xref><xref ref-type="aff" rid="A8">§§</xref></contrib><contrib contrib-type="author"><name><surname>MUNTEANU</surname><given-names>MONA</given-names></name><xref ref-type="aff" rid="A9">||||</xref></contrib><contrib contrib-type="author"><name><surname>BOUSQUET</surname><given-names>LAURENCE</given-names></name><xref ref-type="aff" rid="A2">‡</xref><xref ref-type="aff" rid="A7">‡‡</xref></contrib><contrib contrib-type="author"><name><surname>ARGIRO</surname><given-names>LAURENT</given-names></name><xref ref-type="aff" rid="A10">¶¶</xref></contrib><contrib contrib-type="author"><name><surname>HALFON</surname><given-names>PHILIPPE</given-names></name><xref ref-type="aff" rid="A11">##</xref></contrib><contrib contrib-type="author"><name><surname>BOLAND</surname><given-names>ANNE</given-names></name><xref ref-type="aff" rid="A12">***</xref></contrib><contrib contrib-type="author"><name><surname>MÜLLHAUPT</surname><given-names>BEAT</given-names></name><xref ref-type="aff" rid="A13">‡‡‡</xref></contrib><contrib contrib-type="author"><name><surname>SEMELA</surname><given-names>DAVID</given-names></name><xref ref-type="aff" rid="A14">§§§</xref></contrib><contrib contrib-type="author"><name><surname>DUFOUR</surname><given-names>JEAN-FRANÇOIS</given-names></name><xref ref-type="aff" rid="A15">||||||</xref></contrib><contrib contrib-type="author"><name><surname>HEIM</surname><given-names>MARKUS H.</given-names></name><xref ref-type="aff" rid="A16">¶¶¶</xref></contrib><contrib contrib-type="author"><name><surname>MORADPOUR</surname><given-names>DARIUS</given-names></name><xref ref-type="aff" rid="A17">###</xref></contrib><contrib contrib-type="author"><name><surname>CERNY</surname><given-names>ANDREAS</given-names></name><xref ref-type="aff" rid="A18">****</xref></contrib><contrib contrib-type="author"><name><surname>MALINVERNI</surname><given-names>RAFFAELE</given-names></name><xref ref-type="aff" rid="A19">‡‡‡‡</xref></contrib><contrib contrib-type="author"><name><surname>HIRSCH</surname><given-names>HANS</given-names></name><xref ref-type="aff" rid="A20">§§§§</xref></contrib><contrib contrib-type="author"><name><surname>MARTINETTI</surname><given-names>GLADYS</given-names></name><xref ref-type="aff" rid="A21">||||||||</xref></contrib><contrib contrib-type="author"><name><surname>SUPPIAH</surname><given-names>VIJAYAPRAKASH</given-names></name><xref ref-type="aff" rid="A22">¶¶¶¶</xref><xref ref-type="aff" rid="A23">####</xref></contrib><contrib contrib-type="author"><name><surname>STEWART</surname><given-names>GRAEME</given-names></name><xref ref-type="aff" rid="A23">####</xref></contrib><contrib contrib-type="author"><name><surname>BOOTH</surname><given-names>DAVID R.</given-names></name><xref ref-type="aff" rid="A23">####</xref></contrib><contrib contrib-type="author"><name><surname>GEORGE</surname><given-names>JACOB</given-names></name><xref ref-type="aff" rid="A22">¶¶¶¶</xref></contrib><contrib contrib-type="author"><name><surname>CASANOVA</surname><given-names>JEAN-LAURENT</given-names></name><xref ref-type="aff" rid="A1">*</xref><xref ref-type="aff" rid="A2">‡</xref><xref ref-type="aff" rid="A8">§§</xref></contrib><contrib contrib-type="author"><name><surname>BRÉCHOT</surname><given-names>CHRISTIAN</given-names></name><xref ref-type="aff" rid="A24">*****</xref></contrib><contrib contrib-type="author"><name><surname>RICE</surname><given-names>CHARLES M.</given-names></name><xref ref-type="aff" rid="A25">‡‡‡‡‡</xref></contrib><contrib contrib-type="author"><name><surname>TALAL</surname><given-names>ANDREW H.</given-names></name><xref ref-type="aff" rid="A26">§§§§§</xref></contrib><contrib contrib-type="author"><name><surname>JACOBSON</surname><given-names>IRA M.</given-names></name><xref ref-type="aff" rid="A26">§§§§§</xref></contrib><contrib contrib-type="author"><name><surname>BOURLIÈRE</surname><given-names>MARC</given-names></name><xref ref-type="aff" rid="A27">||||||||||</xref></contrib><contrib contrib-type="author"><name><surname>THEODOROU</surname><given-names>IOANNIS</given-names></name><xref ref-type="aff" rid="A5">#</xref></contrib><contrib contrib-type="author"><name><surname>POYNARD</surname><given-names>THIERRY</given-names></name><xref ref-type="aff" rid="A28">¶¶¶¶¶</xref></contrib><contrib contrib-type="author"><name><surname>NEGRO</surname><given-names>FRANCESCO</given-names></name><xref ref-type="aff" rid="A29">#####</xref></contrib><contrib contrib-type="author"><name><surname>POL</surname><given-names>STANISLAS</given-names></name><xref ref-type="aff" rid="A2">‡</xref><xref ref-type="aff" rid="A7">‡‡</xref></contrib><contrib contrib-type="author"><name><surname>BOCHUD</surname><given-names>PIERRE-YVES</given-names></name><xref ref-type="aff" rid="A6">**</xref></contrib><contrib contrib-type="author"><name><surname>ABEL</surname><given-names>LAURENT</given-names></name><xref ref-type="aff" rid="A1">*</xref><xref ref-type="aff" rid="A2">‡</xref><xref ref-type="aff" rid="A8">§§</xref></contrib><on-behalf-of>on behalf of the Swiss Hepatitis C Cohort Study Group, the International Hepatitis C Genetics Consortium and the French ANRS HC EP 26 Genoscan Study Group</on-behalf-of></contrib-group><aff id="A1"><label>*</label>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, Institut National de la Santé et de la Recherche Médicale (INSERM) U980, Paris, France</aff><aff id="A2"><label>‡</label>University Paris Descartes, Paris, France</aff><aff id="A3"><label>||</label>Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland</aff><aff id="A4"><label>¶</label>Swiss Institute of Bioinformatics, Lausanne, Switzerland</aff><aff id="A5"><label>#</label>Laboratory of Immunity and Infection, INSERM UMR-S 945, UPMC Université Paris 6, Groupe Hospitalier Pitié-Salpêtrière AP-HP, Paris, France</aff><aff id="A6"><label>**</label>Service of Infectious Diseases, Department of Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland</aff><aff id="A7"><label>‡‡</label>Département d’Hépatologie, INSERM U1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris, France</aff><aff id="A8"><label>§§</label>St; Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA</aff><aff id="A9"><label>||||</label>Biopredictive, Paris, France</aff><aff id="A10"><label>¶¶</label>Laboratoire d’Immunologie et de Génétique des Maladies Parasitaires, INSERM-UMR 906/Université de la Méditerranée, Marseilles, France</aff><aff id="A11"><label>##</label>Laboratoire Alphabio, Hôpital Ambroise Paré, Marseilles, France</aff><aff id="A12"><label>***</label>CEA, Institut de Génomique, Centre National de Génotypage, Evry, France</aff><aff id="A13"><label>‡‡‡</label>Division of Gastroenterology and Hepatology, University Hospital, Zurich, Switzerland</aff><aff id="A14"><label>§§§</label>Division of Gastroenterology, Canton Hospital, St Gallen, Switzerland</aff><aff id="A15"><label>||||||</label>Hepatology, Department of Clinical Research, University Clinic for visceral Surgery and Medicine, Bern, Switzerland</aff><aff id="A16"><label>¶¶¶</label>Division of Gastroenterology and Hepatology, University Hospital, Basel, Switzerland</aff><aff id="A17"><label>###</label>Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland</aff><aff id="A18"><label>****</label>Clinica Moncucco, Lugano, Switzerland</aff><aff id="A19"><label>‡‡‡‡</label>Pourtalès Hospital, Neuchâtel, Switzerland</aff><aff id="A20"><label>§§§§</label>Institute for Medical Microbiology, University Hospital, Basel, Switzerland</aff><aff id="A21"><label>||||||||</label>Institute of Medical Microbiology, Bellinzona, Switzerland</aff><aff id="A22"><label>¶¶¶¶</label>Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney, Australia</aff><aff id="A23"><label>####</label>Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia</aff><aff id="A24"><label>*****</label>INSERM U785, Liver Hepatology Centre, Paul Brousse Hospital, University Paris-XI, Villejuif, France</aff><aff id="A25"><label>‡‡‡‡‡</label>Center for the Study of Hepatitis C, Rockefeller University, New York, USA</aff><aff id="A26"><label>§§§§§</label>Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, USA</aff><aff id="A27"><label>||||||||||</label>Service d’Hépato-gastroentérologie, Hôpital Saint-Joseph, Marseilles, France</aff><aff id="A28"><label>¶¶¶¶¶</label>Université Pierre et Marie Curie, Service d’Hépato-gastroentérologie, Hôpital Pitié-Salpêtrière (AP-HP), Paris, France</aff><aff id="A29"><label>#####</label>Divisions of Gastroenterology and Hepatology and of Clinical Pathology, University Hospital, Geneva, Switzerland</aff><author-notes><corresp id="FN1">Reprint request: Address requests for reprints to: Pierre-Yves Bochud, Infectious Diseases Service, Department of Medicine, Institute of Microbiology, Rue du Bugnon 48, CH-1011 Lausanne CHUV, Switzerland. <email>pierre-yves.bochud@chuv.ch</email>; fax: +41 21 314 40 60; or Laurent Abel, Laboratoire de Génétique Humaine des Maladies Infectieuses, Université Paris Descartes-INSERM U980, Faculté de Médecine Necker, 156 rue de Vaugirard, 75015 Paris, France; <email>laurent.abel@inserm.fr</email>, phone: +33 (0)140615689, fax: +33 (0)140615688</corresp><fn id="FN2" fn-type="present-address"><label>§</label><p>Current address: Human Evolutionary Genetics, CNRS URA3012, Institut Pasteur, Paris, France;</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>20</day><month>7</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>27</day><month>7</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>11</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>11</month><year>2013</year></pub-date><volume>143</volume><issue>5</issue><fpage>1244</fpage><lpage>52.e1-12</lpage><permissions><copyright-statement>© 2012 The American Gastroenterological Association. Published by Elsevier Inc. All rights reserved.</copyright-statement><copyright-year>2012</copyright-year></permissions><abstract><sec id="S1"><title>BACKGROUND & AIMS</title><p id="P2">Polymorphisms in <italic>IL28B</italic> were shown to affect clearance of hepatitis C virus (HCV) infection in genome-wide association (GWA) studies. Only a fraction of patients with chronic HCV infection develop liver fibrosis, a process that might also be affected by genetic factors. We carried out a 2-stage GWA study of liver fibrosis progression related to HCV infection.</p></sec><sec id="S2"><title>METHODS</title><p id="P3">We studied well-characterized HCV-infected patients of European descent who had liver biopsies before treatment. We defined various liver fibrosis phenotypes on the basis of Metavir scores, with and without taking the duration of HCV infection into account. Our GWA analyses were conducted on a filtered primary cohort of 1161 patients using 780,650 single nucleotide polymorphisms (SNPs). We genotyped 96 SNPs with <italic>P</italic>-values<5×10<sup>−5</sup> from an independent replication cohort of 962 patients. We then assessed the most interesting replicated SNPs using DNA samples collected from 219 patients who participated in separate GWA studies of HCV clearance.</p></sec><sec id="S3"><title>RESULTS</title><p id="P4">In the combined cohort of 2342 HCV-infected patients, the SNPs rs16851720 (in the total sample) and rs4374383 (in patients that received blood transfusions) were associated with fibrosis progression (<italic><sub>Pcombined</sub></italic>=8.9×10<sup>−9</sup> and 1.1×10<sup>−9</sup>, respectively). The SNP rs16851720 is located within <italic>RNF7</italic>, which encodes an antioxidant that protects against apoptosis. The SNP rs4374383, together with another replicated SNP, rs9380516 (<italic>P<sub>combined</sub></italic>=5.4×10<sup>−7</sup>), were linked to the functionally related genes <italic>MERTK</italic> and <italic>TULP1</italic>, which encode factors involved in phagocytosis of apoptotic cells by macrophages.</p></sec><sec id="S4"><title>CONCLUSIONS</title><p id="P5">Our GWA study identified several susceptibility loci for HCV-induced liver fibrosis; these were linked to genes that regulate apoptosis. Apoptotic control might therefore be involved in liver fibrosis.</p></sec></abstract><kwd-group><kwd>genetic analysis</kwd><kwd>risk factors</kwd><kwd>cirrhosis</kwd><kwd>liver disease</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Center for Research Resources : NCRR</funding-source><award-id>UL1 RR024143 || RR</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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