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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Associations of Breast Cancer Risk Factors With Tumor Subtypes: A Pooled Analysis From the Breast Cancer Association Consortium Studies</title>
<author><name sortKey="Yang, Xiaohong R" sort="Yang, Xiaohong R" uniqKey="Yang X" first="Xiaohong R." last="Yang">Xiaohong R. Yang</name>
</author>
<author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name>
</author>
<author><name sortKey="Goode, Ellen L" sort="Goode, Ellen L" uniqKey="Goode E" first="Ellen L." last="Goode">Ellen L. Goode</name>
</author>
<author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name>
</author>
<author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name>
</author>
<author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name>
</author>
<author><name sortKey="Gaudet, Mia" sort="Gaudet, Mia" uniqKey="Gaudet M" first="Mia" last="Gaudet">Mia Gaudet</name>
</author>
<author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name>
</author>
<author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name>
</author>
<author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name>
</author>
<author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name>
</author>
<author><name sortKey="Hein, Rebecca" sort="Hein, Rebecca" uniqKey="Hein R" first="Rebecca" last="Hein">Rebecca Hein</name>
</author>
<author><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name>
</author>
<author><name sortKey="Blows, Fiona" sort="Blows, Fiona" uniqKey="Blows F" first="Fiona" last="Blows">Fiona Blows</name>
</author>
<author><name sortKey="Driver, Kristy" sort="Driver, Kristy" uniqKey="Driver K" first="Kristy" last="Driver">Kristy Driver</name>
</author>
<author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name>
</author>
<author><name sortKey="Heinz, Judith" sort="Heinz, Judith" uniqKey="Heinz J" first="Judith" last="Heinz">Judith Heinz</name>
</author>
<author><name sortKey="Sinn, Peter" sort="Sinn, Peter" uniqKey="Sinn P" first="Peter" last="Sinn">Peter Sinn</name>
</author>
<author><name sortKey="Vrieling, Alina" sort="Vrieling, Alina" uniqKey="Vrieling A" first="Alina" last="Vrieling">Alina Vrieling</name>
</author>
<author><name sortKey="Heikkinen, Tuomas" sort="Heikkinen, Tuomas" uniqKey="Heikkinen T" first="Tuomas" last="Heikkinen">Tuomas Heikkinen</name>
</author>
<author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name>
</author>
<author><name sortKey="Heikkil, P Ivi" sort="Heikkil, P Ivi" uniqKey="Heikkil P" first="P Ivi" last="Heikkil">P Ivi Heikkil</name>
</author>
<author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name>
</author>
<author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name>
</author>
<author><name sortKey="Peplonska, Beata" sort="Peplonska, Beata" uniqKey="Peplonska B" first="Beata" last="Peplonska">Beata Peplonska</name>
</author>
<author><name sortKey="Chanock, Stephen" sort="Chanock, Stephen" uniqKey="Chanock S" first="Stephen" last="Chanock">Stephen Chanock</name>
</author>
<author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name>
</author>
<author><name sortKey="Brinton, Louise" sort="Brinton, Louise" uniqKey="Brinton L" first="Louise" last="Brinton">Louise Brinton</name>
</author>
<author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name>
</author>
<author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name>
</author>
<author><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name>
</author>
<author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name>
</author>
<author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name>
</author>
<author><name sortKey="Van Veer, Laura J" sort="Van Veer, Laura J" uniqKey="Van Veer L" first="Laura J." last="Van Veer">Laura J. Van Veer</name>
</author>
<author><name sortKey="Van Leeuwen, Flora E" sort="Van Leeuwen, Flora E" uniqKey="Van Leeuwen F" first="Flora E." last="Van Leeuwen">Flora E. Van Leeuwen</name>
</author>
<author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name>
</author>
<author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name>
</author>
<author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name>
</author>
<author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name>
</author>
<author><name sortKey="O Alley, Frances P" sort="O Alley, Frances P" uniqKey="O Alley F" first="Frances P." last="O Alley">Frances P. O Alley</name>
</author>
<author><name sortKey="Weerasooriya, Nayana" sort="Weerasooriya, Nayana" uniqKey="Weerasooriya N" first="Nayana" last="Weerasooriya">Nayana Weerasooriya</name>
</author>
<author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name>
</author>
<author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name>
</author>
<author><name sortKey="Hartmann, Arndt" sort="Hartmann, Arndt" uniqKey="Hartmann A" first="Arndt" last="Hartmann">Arndt Hartmann</name>
</author>
<author><name sortKey="Weihbrecht, Sebastian B" sort="Weihbrecht, Sebastian B" uniqKey="Weihbrecht S" first="Sebastian B." last="Weihbrecht">Sebastian B. Weihbrecht</name>
</author>
<author><name sortKey="Wachter, David L" sort="Wachter, David L" uniqKey="Wachter D" first="David L." last="Wachter">David L. Wachter</name>
</author>
<author><name sortKey="Jud, Sebastian M" sort="Jud, Sebastian M" uniqKey="Jud S" first="Sebastian M." last="Jud">Sebastian M. Jud</name>
</author>
<author><name sortKey="Loehberg, Christian R" sort="Loehberg, Christian R" uniqKey="Loehberg C" first="Christian R." last="Loehberg">Christian R. Loehberg</name>
</author>
<author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name>
</author>
<author><name sortKey="English, Dallas R" sort="English, Dallas R" uniqKey="English D" first="Dallas R." last="English">Dallas R. English</name>
</author>
<author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
</author>
<author><name sortKey="Mclean, Catriona A" sort="Mclean, Catriona A" uniqKey="Mclean C" first="Catriona A." last="Mclean">Catriona A. Mclean</name>
</author>
<author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
</author>
<author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name>
</author>
<author><name sortKey="Vandorpe, Thijs" sort="Vandorpe, Thijs" uniqKey="Vandorpe T" first="Thijs" last="Vandorpe">Thijs Vandorpe</name>
</author>
<author><name sortKey="Weltens, Caroline" sort="Weltens, Caroline" uniqKey="Weltens C" first="Caroline" last="Weltens">Caroline Weltens</name>
</author>
<author><name sortKey="Paridaens, Robert" sort="Paridaens, Robert" uniqKey="Paridaens R" first="Robert" last="Paridaens">Robert Paridaens</name>
</author>
<author><name sortKey="Smeets, Ann" sort="Smeets, Ann" uniqKey="Smeets A" first="Ann" last="Smeets">Ann Smeets</name>
</author>
<author><name sortKey="Neven, Patrick" sort="Neven, Patrick" uniqKey="Neven P" first="Patrick" last="Neven">Patrick Neven</name>
</author>
<author><name sortKey="Wildiers, Hans" sort="Wildiers, Hans" uniqKey="Wildiers H" first="Hans" last="Wildiers">Hans Wildiers</name>
</author>
<author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name>
</author>
<author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name>
</author>
<author><name sortKey="Cafourek, Victoria" sort="Cafourek, Victoria" uniqKey="Cafourek V" first="Victoria" last="Cafourek">Victoria Cafourek</name>
</author>
<author><name sortKey="Fredericksen, Zachary" sort="Fredericksen, Zachary" uniqKey="Fredericksen Z" first="Zachary" last="Fredericksen">Zachary Fredericksen</name>
</author>
<author><name sortKey="Kosel, Matthew" sort="Kosel, Matthew" uniqKey="Kosel M" first="Matthew" last="Kosel">Matthew Kosel</name>
</author>
<author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name>
</author>
<author><name sortKey="Cramp, Helen E" sort="Cramp, Helen E" uniqKey="Cramp H" first="Helen E." last="Cramp">Helen E. Cramp</name>
</author>
<author><name sortKey="Connley, Daniel" sort="Connley, Daniel" uniqKey="Connley D" first="Daniel" last="Connley">Daniel Connley</name>
</author>
<author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name>
</author>
<author><name sortKey="Balasubramanian, Sabapathy P" sort="Balasubramanian, Sabapathy P" uniqKey="Balasubramanian S" first="Sabapathy P." last="Balasubramanian">Sabapathy P. Balasubramanian</name>
</author>
<author><name sortKey="Reed, Malcolm W R" sort="Reed, Malcolm W R" uniqKey="Reed M" first="Malcolm W. R." last="Reed">Malcolm W. R. Reed</name>
</author>
<author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name>
</author>
<author><name sortKey="Bremer, Michael" sort="Bremer, Michael" uniqKey="Bremer M" first="Michael" last="Bremer">Michael Bremer</name>
</author>
<author><name sortKey="Meyer, Andreas" sort="Meyer, Andreas" uniqKey="Meyer A" first="Andreas" last="Meyer">Andreas Meyer</name>
</author>
<author><name sortKey="Karstens, Johann H" sort="Karstens, Johann H" uniqKey="Karstens J" first="Johann H." last="Karstens">Johann H. Karstens</name>
</author>
<author><name sortKey="Ay, Aysun" sort="Ay, Aysun" uniqKey="Ay A" first="Aysun" last="Ay">Aysun Ay</name>
</author>
<author><name sortKey="Park Simon, Tjoung Won" sort="Park Simon, Tjoung Won" uniqKey="Park Simon T" first="Tjoung-Won" last="Park-Simon">Tjoung-Won Park-Simon</name>
</author>
<author><name sortKey="Hillemanns, Peter" sort="Hillemanns, Peter" uniqKey="Hillemanns P" first="Peter" last="Hillemanns">Peter Hillemanns</name>
</author>
<author><name sortKey="Arias Perez, Jose Ignacio" sort="Arias Perez, Jose Ignacio" uniqKey="Arias Perez J" first="Jose Ignacio" last="Arias Pérez">Jose Ignacio Arias Pérez</name>
</author>
<author><name sortKey="Rodriguez, Primitiva Menendez" sort="Rodriguez, Primitiva Menendez" uniqKey="Rodriguez P" first="Primitiva Menéndez" last="Rodríguez">Primitiva Menéndez Rodríguez</name>
</author>
<author><name sortKey="Zamora, Pilar" sort="Zamora, Pilar" uniqKey="Zamora P" first="Pilar" last="Zamora">Pilar Zamora</name>
</author>
<author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name>
</author>
<author><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name>
</author>
<author><name sortKey="Fischer, Hans Peter" sort="Fischer, Hans Peter" uniqKey="Fischer H" first="Hans-Peter" last="Fischer">Hans-Peter Fischer</name>
</author>
<author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name>
</author>
<author><name sortKey="Pesch, Beate" sort="Pesch, Beate" uniqKey="Pesch B" first="Beate" last="Pesch">Beate Pesch</name>
</author>
<author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name>
</author>
<author><name sortKey="Justenhoven, Christina" sort="Justenhoven, Christina" uniqKey="Justenhoven C" first="Christina" last="Justenhoven">Christina Justenhoven</name>
</author>
<author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name>
</author>
<author><name sortKey="Eccles, Diana M" sort="Eccles, Diana M" uniqKey="Eccles D" first="Diana M." last="Eccles">Diana M. Eccles</name>
</author>
<author><name sortKey="Tapper, William J" sort="Tapper, William J" uniqKey="Tapper W" first="William J." last="Tapper">William J. Tapper</name>
</author>
<author><name sortKey="Gerty, Sue M" sort="Gerty, Sue M" uniqKey="Gerty S" first="Sue M." last="Gerty">Sue M. Gerty</name>
</author>
<author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name>
</author>
<author><name sortKey="Tomlinson, Ian P" sort="Tomlinson, Ian P" uniqKey="Tomlinson I" first="Ian P." last="Tomlinson">Ian P. Tomlinson</name>
</author>
<author><name sortKey="Jones, Angela" sort="Jones, Angela" uniqKey="Jones A" first="Angela" last="Jones">Angela Jones</name>
</author>
<author><name sortKey="Kerin, Michael" sort="Kerin, Michael" uniqKey="Kerin M" first="Michael" last="Kerin">Michael Kerin</name>
</author>
<author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name>
</author>
<author><name sortKey="Mcinerney, Niall" sort="Mcinerney, Niall" uniqKey="Mcinerney N" first="Niall" last="Mcinerney">Niall Mcinerney</name>
</author>
<author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name>
</author>
<author><name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name>
</author>
<author><name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name>
</author>
<author><name sortKey="Hsiung, Chia Ni" sort="Hsiung, Chia Ni" uniqKey="Hsiung C" first="Chia-Ni" last="Hsiung">Chia-Ni Hsiung</name>
</author>
<author><name sortKey="Wu, Pei Ei" sort="Wu, Pei Ei" uniqKey="Wu P" first="Pei-Ei" last="Wu">Pei-Ei Wu</name>
</author>
<author><name sortKey="Yang, Show Lin" sort="Yang, Show Lin" uniqKey="Yang S" first="Show-Lin" last="Yang">Show-Lin Yang</name>
</author>
<author><name sortKey="Yu, Jyh Cherng" sort="Yu, Jyh Cherng" uniqKey="Yu J" first="Jyh-Cherng" last="Yu">Jyh-Cherng Yu</name>
</author>
<author><name sortKey="Chen, Shou Tung" sort="Chen, Shou Tung" uniqKey="Chen S" first="Shou-Tung" last="Chen">Shou-Tung Chen</name>
</author>
<author><name sortKey="Hsu, Giu Cheng" sort="Hsu, Giu Cheng" uniqKey="Hsu G" first="Giu-Cheng" last="Hsu">Giu-Cheng Hsu</name>
</author>
<author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name>
</author>
<author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name>
</author>
<author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name>
</author>
<author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N." last="Kolonel">Laurence N. Kolonel</name>
</author>
<author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name>
</author>
<author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name>
</author>
<author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name>
</author>
<author><name sortKey="Lubi Ski, Jan" sort="Lubi Ski, Jan" uniqKey="Lubi Ski J" first="Jan" last="Lubi Ski">Jan Lubi Ski</name>
</author>
<author><name sortKey="Huzarski, Tomasz" sort="Huzarski, Tomasz" uniqKey="Huzarski T" first="Tomasz" last="Huzarski">Tomasz Huzarski</name>
</author>
<author><name sortKey="Byrski, Tomasz" sort="Byrski, Tomasz" uniqKey="Byrski T" first="Tomasz" last="Byrski">Tomasz Byrski</name>
</author>
<author><name sortKey="G Rski, Bohdan" sort="G Rski, Bohdan" uniqKey="G Rski B" first="Bohdan" last="G Rski">Bohdan G Rski</name>
</author>
<author><name sortKey="Gronwald, Jacek" sort="Gronwald, Jacek" uniqKey="Gronwald J" first="Jacek" last="Gronwald">Jacek Gronwald</name>
</author>
<author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name>
</author>
<author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name>
</author>
<author><name sortKey="Van Den Ouweland, Ans M W" sort="Van Den Ouweland, Ans M W" uniqKey="Van Den Ouweland A" first="Ans M. W." last="Van Den Ouweland">Ans M. W. Van Den Ouweland</name>
</author>
<author><name sortKey="Jager, Agnes" sort="Jager, Agnes" uniqKey="Jager A" first="Agnes" last="Jager">Agnes Jager</name>
</author>
<author><name sortKey="Kriege, Mieke" sort="Kriege, Mieke" uniqKey="Kriege M" first="Mieke" last="Kriege">Mieke Kriege</name>
</author>
<author><name sortKey="Tilanus Linthorst, Madeleine M A" sort="Tilanus Linthorst, Madeleine M A" uniqKey="Tilanus Linthorst M" first="Madeleine M. A." last="Tilanus-Linthorst">Madeleine M. A. Tilanus-Linthorst</name>
</author>
<author><name sortKey="Collee, Margriet" sort="Collee, Margriet" uniqKey="Collee M" first="Margriet" last="Collée">Margriet Collée</name>
</author>
<author><name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name>
</author>
<author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name>
</author>
<author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name>
</author>
<author><name sortKey="Mononen, Kari" sort="Mononen, Kari" uniqKey="Mononen K" first="Kari" last="Mononen">Kari Mononen</name>
</author>
<author><name sortKey="Grip, Mervi" sort="Grip, Mervi" uniqKey="Grip M" first="Mervi" last="Grip">Mervi Grip</name>
</author>
<author><name sortKey="Hirvikoski, Pasi" sort="Hirvikoski, Pasi" uniqKey="Hirvikoski P" first="Pasi" last="Hirvikoski">Pasi Hirvikoski</name>
</author>
<author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name>
</author>
<author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name>
</author>
<author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name>
</author>
<author><name sortKey="Kauppinen, Jaana" sort="Kauppinen, Jaana" uniqKey="Kauppinen J" first="Jaana" last="Kauppinen">Jaana Kauppinen</name>
</author>
<author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name>
</author>
<author><name sortKey="Auvinen, P Ivi" sort="Auvinen, P Ivi" uniqKey="Auvinen P" first="P Ivi" last="Auvinen">P Ivi Auvinen</name>
</author>
<author><name sortKey="Soini, Ylermi" sort="Soini, Ylermi" uniqKey="Soini Y" first="Ylermi" last="Soini">Ylermi Soini</name>
</author>
<author><name sortKey="Sironen, Reijo" sort="Sironen, Reijo" uniqKey="Sironen R" first="Reijo" last="Sironen">Reijo Sironen</name>
</author>
<author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name>
</author>
<author><name sortKey="Dynnes Rsted, David" sort="Dynnes Rsted, David" uniqKey="Dynnes Rsted D" first="David" last="Dynnes Rsted">David Dynnes Rsted</name>
</author>
<author><name sortKey="Kaur Knudsen, Diljit" sort="Kaur Knudsen, Diljit" uniqKey="Kaur Knudsen D" first="Diljit" last="Kaur-Knudsen">Diljit Kaur-Knudsen</name>
</author>
<author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name>
</author>
<author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name>
</author>
<author><name sortKey="Holland, Helene" sort="Holland, Helene" uniqKey="Holland H" first="Helene" last="Holland">Helene Holland</name>
</author>
<author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
</author>
<author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name>
</author>
<author><name sortKey="Barile, Monica" sort="Barile, Monica" uniqKey="Barile M" first="Monica" last="Barile">Monica Barile</name>
</author>
<author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name>
</author>
<author><name sortKey="Hankinson, Susan E" sort="Hankinson, Susan E" uniqKey="Hankinson S" first="Susan E." last="Hankinson">Susan E. Hankinson</name>
</author>
<author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name>
</author>
<author><name sortKey="Tamimi, Rulla" sort="Tamimi, Rulla" uniqKey="Tamimi R" first="Rulla" last="Tamimi">Rulla Tamimi</name>
</author>
<author><name sortKey="Sangrajrang, Suleeporn" sort="Sangrajrang, Suleeporn" uniqKey="Sangrajrang S" first="Suleeporn" last="Sangrajrang">Suleeporn Sangrajrang</name>
</author>
<author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name>
</author>
<author><name sortKey="Mckay, James" sort="Mckay, James" uniqKey="Mckay J" first="James" last="Mckay">James Mckay</name>
</author>
<author><name sortKey="Odefrey, Fabrice" sort="Odefrey, Fabrice" uniqKey="Odefrey F" first="Fabrice" last="Odefrey">Fabrice Odefrey</name>
</author>
<author><name sortKey="Gaborieau, Valerie" sort="Gaborieau, Valerie" uniqKey="Gaborieau V" first="Valerie" last="Gaborieau">Valerie Gaborieau</name>
</author>
<author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name>
</author>
<author><name sortKey="Huijts, P E A" sort="Huijts, P E A" uniqKey="Huijts P" first="P. E. A." last="Huijts">P. E. A. Huijts</name>
</author>
<author><name sortKey="Tollenaar, Raem" sort="Tollenaar, Raem" uniqKey="Tollenaar R" first="Raem." last="Tollenaar">Raem. Tollenaar</name>
</author>
<author><name sortKey="Seynaeve, C" sort="Seynaeve, C" uniqKey="Seynaeve C" first="C." last="Seynaeve">C. Seynaeve</name>
</author>
<author><name sortKey="Dite, Gillian S" sort="Dite, Gillian S" uniqKey="Dite G" first="Gillian S." last="Dite">Gillian S. Dite</name>
</author>
<author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name>
</author>
<author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name>
</author>
<author><name sortKey="Hammet, Fleur" sort="Hammet, Fleur" uniqKey="Hammet F" first="Fleur" last="Hammet">Fleur Hammet</name>
</author>
<author><name sortKey="Tsimiklis, Helen" sort="Tsimiklis, Helen" uniqKey="Tsimiklis H" first="Helen" last="Tsimiklis">Helen Tsimiklis</name>
</author>
<author><name sortKey="Smith, Letitia D" sort="Smith, Letitia D" uniqKey="Smith L" first="Letitia D." last="Smith">Letitia D. Smith</name>
</author>
<author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name>
</author>
<author><name sortKey="Humphreys, Manjeet K" sort="Humphreys, Manjeet K" uniqKey="Humphreys M" first="Manjeet K." last="Humphreys">Manjeet K. Humphreys</name>
</author>
<author><name sortKey="Easton, Douglas" sort="Easton, Douglas" uniqKey="Easton D" first="Douglas" last="Easton">Douglas Easton</name>
</author>
<author><name sortKey="Pharoah, Paul" sort="Pharoah, Paul" uniqKey="Pharoah P" first="Paul" last="Pharoah">Paul Pharoah</name>
</author>
<author><name sortKey="Sherman, Mark E" sort="Sherman, Mark E" uniqKey="Sherman M" first="Mark E." last="Sherman">Mark E. Sherman</name>
</author>
<author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name>
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</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">21191117</idno>
<idno type="pmc">3107570</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107570</idno>
<idno type="RBID">PMC:3107570</idno>
<idno type="doi">10.1093/jnci/djq526</idno>
<date when="2010">2010</date>
<idno type="wicri:Area/Pmc/Corpus">001986</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001986</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Associations of Breast Cancer Risk Factors With Tumor Subtypes: A Pooled Analysis From the Breast Cancer Association Consortium Studies</title>
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<author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name>
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<author><name sortKey="Weltens, Caroline" sort="Weltens, Caroline" uniqKey="Weltens C" first="Caroline" last="Weltens">Caroline Weltens</name>
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<author><name sortKey="Smeets, Ann" sort="Smeets, Ann" uniqKey="Smeets A" first="Ann" last="Smeets">Ann Smeets</name>
</author>
<author><name sortKey="Neven, Patrick" sort="Neven, Patrick" uniqKey="Neven P" first="Patrick" last="Neven">Patrick Neven</name>
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<author><name sortKey="Wildiers, Hans" sort="Wildiers, Hans" uniqKey="Wildiers H" first="Hans" last="Wildiers">Hans Wildiers</name>
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<author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name>
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<author><name sortKey="Cafourek, Victoria" sort="Cafourek, Victoria" uniqKey="Cafourek V" first="Victoria" last="Cafourek">Victoria Cafourek</name>
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<author><name sortKey="Fredericksen, Zachary" sort="Fredericksen, Zachary" uniqKey="Fredericksen Z" first="Zachary" last="Fredericksen">Zachary Fredericksen</name>
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<author><name sortKey="Kosel, Matthew" sort="Kosel, Matthew" uniqKey="Kosel M" first="Matthew" last="Kosel">Matthew Kosel</name>
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<author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name>
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<author><name sortKey="Cramp, Helen E" sort="Cramp, Helen E" uniqKey="Cramp H" first="Helen E." last="Cramp">Helen E. Cramp</name>
</author>
<author><name sortKey="Connley, Daniel" sort="Connley, Daniel" uniqKey="Connley D" first="Daniel" last="Connley">Daniel Connley</name>
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<author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name>
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<author><name sortKey="Balasubramanian, Sabapathy P" sort="Balasubramanian, Sabapathy P" uniqKey="Balasubramanian S" first="Sabapathy P." last="Balasubramanian">Sabapathy P. Balasubramanian</name>
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</author>
<author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name>
</author>
<author><name sortKey="Bremer, Michael" sort="Bremer, Michael" uniqKey="Bremer M" first="Michael" last="Bremer">Michael Bremer</name>
</author>
<author><name sortKey="Meyer, Andreas" sort="Meyer, Andreas" uniqKey="Meyer A" first="Andreas" last="Meyer">Andreas Meyer</name>
</author>
<author><name sortKey="Karstens, Johann H" sort="Karstens, Johann H" uniqKey="Karstens J" first="Johann H." last="Karstens">Johann H. Karstens</name>
</author>
<author><name sortKey="Ay, Aysun" sort="Ay, Aysun" uniqKey="Ay A" first="Aysun" last="Ay">Aysun Ay</name>
</author>
<author><name sortKey="Park Simon, Tjoung Won" sort="Park Simon, Tjoung Won" uniqKey="Park Simon T" first="Tjoung-Won" last="Park-Simon">Tjoung-Won Park-Simon</name>
</author>
<author><name sortKey="Hillemanns, Peter" sort="Hillemanns, Peter" uniqKey="Hillemanns P" first="Peter" last="Hillemanns">Peter Hillemanns</name>
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<author><name sortKey="Arias Perez, Jose Ignacio" sort="Arias Perez, Jose Ignacio" uniqKey="Arias Perez J" first="Jose Ignacio" last="Arias Pérez">Jose Ignacio Arias Pérez</name>
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<author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name>
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<author><name sortKey="Fischer, Hans Peter" sort="Fischer, Hans Peter" uniqKey="Fischer H" first="Hans-Peter" last="Fischer">Hans-Peter Fischer</name>
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<author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name>
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<author><name sortKey="Pesch, Beate" sort="Pesch, Beate" uniqKey="Pesch B" first="Beate" last="Pesch">Beate Pesch</name>
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<author><name sortKey="Justenhoven, Christina" sort="Justenhoven, Christina" uniqKey="Justenhoven C" first="Christina" last="Justenhoven">Christina Justenhoven</name>
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<author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name>
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<author><name sortKey="Tomlinson, Ian P" sort="Tomlinson, Ian P" uniqKey="Tomlinson I" first="Ian P." last="Tomlinson">Ian P. Tomlinson</name>
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<author><name sortKey="Jones, Angela" sort="Jones, Angela" uniqKey="Jones A" first="Angela" last="Jones">Angela Jones</name>
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<author><name sortKey="Kerin, Michael" sort="Kerin, Michael" uniqKey="Kerin M" first="Michael" last="Kerin">Michael Kerin</name>
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<author><name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name>
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<author><name sortKey="Grip, Mervi" sort="Grip, Mervi" uniqKey="Grip M" first="Mervi" last="Grip">Mervi Grip</name>
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<author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name>
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<author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
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<author><name sortKey="Hankinson, Susan E" sort="Hankinson, Susan E" uniqKey="Hankinson S" first="Susan E." last="Hankinson">Susan E. Hankinson</name>
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<author><name sortKey="Sangrajrang, Suleeporn" sort="Sangrajrang, Suleeporn" uniqKey="Sangrajrang S" first="Suleeporn" last="Sangrajrang">Suleeporn Sangrajrang</name>
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<author><name sortKey="Mckay, James" sort="Mckay, James" uniqKey="Mckay J" first="James" last="Mckay">James Mckay</name>
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</author>
<author><name sortKey="Gaborieau, Valerie" sort="Gaborieau, Valerie" uniqKey="Gaborieau V" first="Valerie" last="Gaborieau">Valerie Gaborieau</name>
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<author><name sortKey="Huijts, P E A" sort="Huijts, P E A" uniqKey="Huijts P" first="P. E. A." last="Huijts">P. E. A. Huijts</name>
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<author><name sortKey="Seynaeve, C" sort="Seynaeve, C" uniqKey="Seynaeve C" first="C." last="Seynaeve">C. Seynaeve</name>
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<author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name>
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<author><name sortKey="Tsimiklis, Helen" sort="Tsimiklis, Helen" uniqKey="Tsimiklis H" first="Helen" last="Tsimiklis">Helen Tsimiklis</name>
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<author><name sortKey="Pharoah, Paul" sort="Pharoah, Paul" uniqKey="Pharoah P" first="Paul" last="Pharoah">Paul Pharoah</name>
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<author><name sortKey="Sherman, Mark E" sort="Sherman, Mark E" uniqKey="Sherman M" first="Mark E." last="Sherman">Mark E. Sherman</name>
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<series><title level="j">JNCI Journal of the National Cancer Institute</title>
<idno type="ISSN">0027-8874</idno>
<idno type="eISSN">1460-2105</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
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<profileDesc><textClass></textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Previous studies have suggested that breast cancer risk factors are associated with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors.</p>
</sec>
<sec><title>Methods</title>
<p>We pooled tumor marker and epidemiological risk factor data from 35 568 invasive breast cancer case patients from 34 studies participating in the Breast Cancer Association Consortium. Logistic regression models were used in case–case analyses to estimate associations between epidemiological risk factors and tumor subtypes, and case–control analyses to estimate associations between epidemiological risk factors and the risk of developing specific tumor subtypes in 12 population-based studies. All statistical tests were two-sided.</p>
</sec>
<sec><title>Results</title>
<p>In case–case analyses, of the epidemiological risk factors examined, early age at menarche (≤12 years) was less frequent in case patients with PR<sup>−</sup>
than PR<sup>+</sup>
tumors (<italic>P</italic>
= .001). Nulliparity (<italic>P</italic>
= 3 × 10<sup>−6</sup>
) and increasing age at first birth (<italic>P</italic>
= 2 × 10<sup>−9</sup>
) were less frequent in ER<sup>−</sup>
than in ER<sup>+</sup>
tumors. Obesity (body mass index [BMI] ≥ 30 kg/m<sup>2</sup>
) in younger women (≤50 years) was more frequent in ER<sup>−</sup>
/PR<sup>−</sup>
than in ER<sup>+</sup>
/PR<sup>+</sup>
tumors (<italic>P</italic>
= 1 × 10<sup>−7</sup>
), whereas obesity in older women (>50 years) was less frequent in PR<sup>−</sup>
than in PR<sup>+</sup>
tumors (<italic>P</italic>
= 6 × 10<sup>−4</sup>
). The triple-negative (ER<sup>−</sup>
/PR<sup>−</sup>
/HER2<sup>−</sup>
) or core basal phenotype (CBP; triple-negative and cytokeratins [CK]5/6<sup>+</sup>
and/or epidermal growth factor receptor [EGFR]<sup>+</sup>
) accounted for much of the heterogeneity in parity-related variables and BMI in younger women. Case–control analyses showed that nulliparity, increasing age at first birth, and obesity in younger women showed the expected associations with the risk of ER<sup>+</sup>
or PR<sup>+</sup>
tumors but not triple-negative (nulliparity vs parity, odds ratio [OR] = 0.94, 95% confidence interval [CI] = 0.75 to 1.19, <italic>P</italic>
= .61; 5-year increase in age at first full-term birth, OR = 0.95, 95% CI = 0.86 to 1.05, <italic>P</italic>
= .34; obesity in younger women, OR = 1.36, 95% CI = 0.95 to 1.94, <italic>P</italic>
= .09) or CBP tumors.</p>
</sec>
<sec><title>Conclusions</title>
<p>This study shows that reproductive factors and BMI are most clearly associated with hormone receptor–positive tumors and suggest that triple-negative or CBP tumors may have distinct etiology.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Natl Cancer Inst</journal-id>
<journal-id journal-id-type="hwp">jnci</journal-id>
<journal-id journal-id-type="publisher-id">jnci</journal-id>
<journal-title-group><journal-title>JNCI Journal of the National Cancer Institute</journal-title>
</journal-title-group>
<issn pub-type="ppub">0027-8874</issn>
<issn pub-type="epub">1460-2105</issn>
<publisher><publisher-name>Oxford University Press</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21191117</article-id>
<article-id pub-id-type="pmc">3107570</article-id>
<article-id pub-id-type="doi">10.1093/jnci/djq526</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Articles</subject>
</subj-group>
</article-categories>
<title-group><article-title>Associations of Breast Cancer Risk Factors With Tumor Subtypes: A Pooled Analysis From the Breast Cancer Association Consortium Studies</article-title>
</title-group>
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<given-names>Kristiina</given-names>
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<given-names>Päivi</given-names>
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<given-names>Carl</given-names>
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<given-names>Jolanta</given-names>
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<given-names>Stephen</given-names>
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<contrib contrib-type="author"><name><surname>Figueroa</surname>
<given-names>Jonine</given-names>
</name>
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<contrib contrib-type="author"><name><surname>Brinton</surname>
<given-names>Louise</given-names>
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<contrib contrib-type="author"><name><surname>Hall</surname>
<given-names>Per</given-names>
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<contrib contrib-type="author"><name><surname>Czene</surname>
<given-names>Kamila</given-names>
</name>
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<contrib contrib-type="author"><name><surname>Humphreys</surname>
<given-names>Keith</given-names>
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<contrib contrib-type="author"><name><surname>Darabi</surname>
<given-names>Hatef</given-names>
</name>
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<contrib contrib-type="author"><name><surname>Liu</surname>
<given-names>Jianjun</given-names>
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<given-names>Irene L.</given-names>
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<given-names>Julia A.</given-names>
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</name>
</contrib>
<contrib contrib-type="author"><name><surname>Hartmann</surname>
<given-names>Arndt</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Weihbrecht</surname>
<given-names>Sebastian B.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Wachter</surname>
<given-names>David L.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Jud</surname>
<given-names>Sebastian M.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Loehberg</surname>
<given-names>Christian R.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Baglietto</surname>
<given-names>Laura</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>English</surname>
<given-names>Dallas R.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Giles</surname>
<given-names>Graham G.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>McLean</surname>
<given-names>Catriona A.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Severi</surname>
<given-names>Gianluca</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Lambrechts</surname>
<given-names>Diether</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Vandorpe</surname>
<given-names>Thijs</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Weltens</surname>
<given-names>Caroline</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Paridaens</surname>
<given-names>Robert</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Smeets</surname>
<given-names>Ann</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Neven</surname>
<given-names>Patrick</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Wildiers</surname>
<given-names>Hans</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Xianshu</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Olson</surname>
<given-names>Janet E.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Cafourek</surname>
<given-names>Victoria</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Fredericksen</surname>
<given-names>Zachary</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Kosel</surname>
<given-names>Matthew</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Vachon</surname>
<given-names>Celine</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Cramp</surname>
<given-names>Helen E.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Connley</surname>
<given-names>Daniel</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Cross</surname>
<given-names>Simon S.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Balasubramanian</surname>
<given-names>Sabapathy P.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Reed</surname>
<given-names>Malcolm W. R.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Dörk</surname>
<given-names>Thilo</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Bremer</surname>
<given-names>Michael</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Meyer</surname>
<given-names>Andreas</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Karstens</surname>
<given-names>Johann H.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Ay</surname>
<given-names>Aysun</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Park-Simon</surname>
<given-names>Tjoung-Won</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Hillemanns</surname>
<given-names>Peter</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Arias Pérez</surname>
<given-names>Jose Ignacio</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Rodríguez</surname>
<given-names>Primitiva Menéndez</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Zamora</surname>
<given-names>Pilar</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Benítez</surname>
<given-names>Javier</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Ko</surname>
<given-names>Yon-Dschun</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Fischer</surname>
<given-names>Hans-Peter</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Hamann</surname>
<given-names>Ute</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Pesch</surname>
<given-names>Beate</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Brüning</surname>
<given-names>Thomas</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Justenhoven</surname>
<given-names>Christina</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Brauch</surname>
<given-names>Hiltrud</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Eccles</surname>
<given-names>Diana M.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Tapper</surname>
<given-names>William J.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Gerty</surname>
<given-names>Sue M.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Sawyer</surname>
<given-names>Elinor J.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Tomlinson</surname>
<given-names>Ian P.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Jones</surname>
<given-names>Angela</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Kerin</surname>
<given-names>Michael</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Miller</surname>
<given-names>Nicola</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>McInerney</surname>
<given-names>Niall</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Anton-Culver</surname>
<given-names>Hoda</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Ziogas</surname>
<given-names>Argyrios</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Shen</surname>
<given-names>Chen-Yang</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Hsiung</surname>
<given-names>Chia-Ni</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Wu</surname>
<given-names>Pei-Ei</given-names>
</name>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Yang</surname>
<given-names>Show-Lin</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Yu</surname>
<given-names>Jyh-Cherng</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>Shou-Tung</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Hsu</surname>
<given-names>Giu-Cheng</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Haiman</surname>
<given-names>Christopher A.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Henderson</surname>
<given-names>Brian E.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Le Marchand</surname>
<given-names>Loic</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Kolonel</surname>
<given-names>Laurence N.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Lindblom</surname>
<given-names>Annika</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Margolin</surname>
<given-names>Sara</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Jakubowska</surname>
<given-names>Anna</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Lubiński</surname>
<given-names>Jan</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Huzarski</surname>
<given-names>Tomasz</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Byrski</surname>
<given-names>Tomasz</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Górski</surname>
<given-names>Bohdan</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Gronwald</surname>
<given-names>Jacek</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Hooning</surname>
<given-names>Maartje J.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Hollestelle</surname>
<given-names>Antoinette</given-names>
</name>
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<contrib contrib-type="author"><name><surname>van den Ouweland</surname>
<given-names>Ans M. W.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Jager</surname>
<given-names>Agnes</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Kriege</surname>
<given-names>Mieke</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Tilanus-Linthorst</surname>
<given-names>Madeleine M. A.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Collée</surname>
<given-names>Margriet</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Wang-Gohrke</surname>
<given-names>Shan</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Pylkäs</surname>
<given-names>Katri</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Jukkola-Vuorinen</surname>
<given-names>Arja</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Mononen</surname>
<given-names>Kari</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Grip</surname>
<given-names>Mervi</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Hirvikoski</surname>
<given-names>Pasi</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Winqvist</surname>
<given-names>Robert</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Mannermaa</surname>
<given-names>Arto</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Kosma</surname>
<given-names>Veli-Matti</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Kauppinen</surname>
<given-names>Jaana</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Kataja</surname>
<given-names>Vesa</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Auvinen</surname>
<given-names>Päivi</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Soini</surname>
<given-names>Ylermi</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Sironen</surname>
<given-names>Reijo</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Bojesen</surname>
<given-names>Stig E.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Dynnes Ørsted</surname>
<given-names>David</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Kaur-Knudsen</surname>
<given-names>Diljit</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Flyger</surname>
<given-names>Henrik</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Nordestgaard</surname>
<given-names>Børge G.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Holland</surname>
<given-names>Helene</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Chenevix-Trench</surname>
<given-names>Georgia</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Manoukian</surname>
<given-names>Siranoush</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Barile</surname>
<given-names>Monica</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Radice</surname>
<given-names>Paolo</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Hankinson</surname>
<given-names>Susan E.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Hunter</surname>
<given-names>David J.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Tamimi</surname>
<given-names>Rulla</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Sangrajrang</surname>
<given-names>Suleeporn</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Brennan</surname>
<given-names>Paul</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>McKay</surname>
<given-names>James</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Odefrey</surname>
<given-names>Fabrice</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Gaborieau</surname>
<given-names>Valerie</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Devilee</surname>
<given-names>Peter</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Huijts</surname>
<given-names>P.E.A.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Tollenaar</surname>
<given-names>RAEM.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Seynaeve</surname>
<given-names>C.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Dite</surname>
<given-names>Gillian S.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Apicella</surname>
<given-names>Carmel</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Hopper</surname>
<given-names>John L.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Hammet</surname>
<given-names>Fleur</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Tsimiklis</surname>
<given-names>Helen</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Smith</surname>
<given-names>Letitia D.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Southey</surname>
<given-names>Melissa C.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Humphreys</surname>
<given-names>Manjeet K.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Easton</surname>
<given-names>Douglas</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Pharoah</surname>
<given-names>Paul</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Sherman</surname>
<given-names>Mark E.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Garcia-Closas</surname>
<given-names>Montserrat</given-names>
</name>
</contrib>
</contrib-group>
<aff><bold>Affiliations of authors:</bold>
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Sciences, Rockville, MD (XRY, SC, JF, LBr, MES, MG-C); Section of Epidemiology and Genetics, Institute of Cancer Research, Sutton, Surrey, UK (MG-C); Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany (JC-C, RH, AV); Department of Health Sciences Research (ELG, FJC, JEO, VC, ZF, MKo, CV); Department of Laboratory Medicine and Pathology (FJC, XW), Mayo Clinic, Rochester, MN; Department of Obstetrics and Gynecology (HN, THe), Department of Clinical Genetics (KA), Department of Pathology (PHe), and Department of Oncology (CB), Helsinki University Central Hospital, Helsinki, Finland; Genetic and Molecular Epidemiology Group (RLM), Human Cancer Genetic Group (JB), Spanish National Cancer Research Centre (CNIO), Madrid, Spain; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (MGa); Amsterdam Breast Cancer Study, Netherlands Cancer Institute, Amsterdam, the Netherlands (MKS, AB, LJVV, FEvL); Institute for Cancer Studies, Department of Oncology (AC, DC,HEC), Academic Unit of Pathology (SCC), Academic Unit of Surgical Oncology, Department of Oncology (SPB, MWRR), University of Sheffield Medical School, Sheffield, UK; Division of Hematology and Oncology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA (PAF); Department of Gynecology and Obstetrics, (MWB, SBW, SMJ, CRL), Institute of Pathology (AHa, DLW), University Breast Center Franconia, University Breast Center, University Hospital Erlangen, Erlangen, Germany; The Queensland Institute of Medical Research Post Office, Royal Brisbane Hospital, Herston, Queensland, Australia (ABS, HH, GC-T); Department of Oncology, University of Cambridge, Cambridge, UK (FB, KD, MKH, DE, PP, MG-C); Department of Medical Biometrics and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (DF-J, JH); Department of Pathology, University Hospital, Heidelberg, Germany (PS); Department of Cancer Epidemiology and Prevention, Cancer Center and M. Sklodowska-Curie Institute of Oncology, Warsaw, Poland (JLi); Department of Occupational and Environmental Epidemiology Nofer Institute of Occupational Medicine, Lodz, Poland (BP); Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden (PHa, KC, KH, HD); Human Genetics, Genome Institute of Singapore, Singapore, Singapore (JLi); Ontario Cancer Genetics Network (OCGN), Cancer Care Ontario, Toronto, ON, Canada (ILA, GG, NW); Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada (ILA); Dalla Lana School of Public Health, University of Toronto, Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada (JAK); Keenan Research Centre, Li Ka Shing Knowledge Institute of St. Michael’s Hospital, and Laboratory Medicine and Pathobiology (AMM), Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, and Laboratory Medicine and Pathobiology (FPOM), University of Toronto, Toronto, Ontario, Canada Northern California Cancer Center, Fremont, CA (EMJ); Department of Health Research and Policy, Stanford University School of Medicine and Stanford Cancer Center, Stanford, CA (EMJ); Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (LB, DRE, GGG, GS); Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia (LBa, DRE, GGG, GS, GSD, CA, JLH); The Alfred Hospital, Melbourne, Australia (CAM); Vesalius Research Center, KU Leuven and VIB, Leuven, Belgium (DL); Department of Radiotherapy, University Hospitals, Leuven, Belgium (TV, CW, RP, AS, PN, HW); Department of Obstetrics and Gynaecology (TD, AA, T-WP-S, PH), Department of Radiation Oncology (MB, AM, JHK), Hanover Medical School, Hanover, Germany (TD, MBr, AMe, JHK, AA, T-WP-S, PHi); Servicio Cirugía General (JIAP), Servicio de Anatomía Patológica (PMR), Hospital Monte Naranco, Oviedo, Spain Servicio de Oncología Médica, Hospital La Paz, Madrid, Spain (PZ); CIBERER, Madrid, Spain (JB); Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany (Y-DK); Institute of Pathology, Medical Faculty of the University of Bonn, Bonn, Germany (H-PF); Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany (UH); Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum, Germany (BP, TBr ); Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany (CJ, HB); University of Tübingen, Tübingen, Germany (CJ, HB); University of Southampton School of Medicine, Southampton University Hospitals NHS Trust, Southampton (DME, WJT, SMG); Guy’s, King’s, St Thomas’ Cancer Centre, Guy’s Hospital, London, UK (EJS); Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK (EJS, IPT, AJo, NMc); Clinical Science Institute, University College Hospital, Galway, Ireland (MKe, NMc, NMi); Department of Epidemiology, University of California Irvine, Irvine (HA-C, AZ); Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan (C-YS, C-NH, P-EW, S-LY); Graduate Institute of Environmental Science, China Medical University, Taichung, Taiwan (C-YS); Department of Surgery (J-CY), Department of Radiology (G-CH), Tri-Service General Hospital, Taipei, Taiwan (J-CY, G-CH); Department of Surgery, Changhua Christian Hospital, Changhua, Taiwan (S-TC); Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (CAH, BEH); Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI (LLM, LNK); Department of Molecular Medicine and Surgery (AL), Department of Oncology and Pathology (SMa), Karolinska Institutet, Stockholm, Sweden; International Hereditary Cancer Centre, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland (AJa, JLu, THu, TBy, BG, JG); Department of Medical Oncology Rotterdam Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, the Netherlands (MJH, AHo, AMWvdO, AJa, MKr, MMAT-L, MC); Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany (SW-G); University of Oulu, Oulu University Hospital, Oulu, Finland (KP, AJ-V, KM, MGr, PHi, RW); Department of Pathology, Institute of Clinical Medicine, University of Eastern Finland and Kuopio University Hospital; Biocenter Kuopio, Kuopio, Finland (AMa, V-MK, JK, YS, RS); Department of Oncology, Vaasa Central Hospital, Vaasa, Finland (VK); Department of Oncology, Kuopio University Hospital, Kuopio, Finland (PA); The Peter MacCallum Cancer Centre, East Melbourne, Australia (kConFab); Department of Clinical Biochemistry and Department of Breast Surgery, Herlev University Hospital, University of Copenhagen, Copenhagen, Denmark (SEB, DDØ, DK-K, HF, BGN); Unit of Medical Genetics, Department of Preventive and Predictive Medicine (SMa), Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine (PR), Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy; Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy (MBa); Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA (SEH, DJH, RT); Department of Epidemiology, Harvard School of Public Health, Boston, MA (SEH, DJH, RT); Molecular Epidemiology Unit, National Cancer Institute, Ratchathewi, Bangkok, Thailand (SS); International Agency for Research on Cancer, Lyon, France (PB, JM, FO, VG); Department of Human Genetics (PD), Department of Pathology (PD), Department of Clinical Genetics (PEAH), Department of Surgical Oncology (RAEMT), Leiden University Medical Center, Leiden, the Netherlands; Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, the Netherlands (CS); The Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Victoria, Australia (FH, HT, LDS, MCS)</aff>
<author-notes><corresp><bold>Correspondence to:</bold>
Xiaohong Rose Yang, PhD, MPH, Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Sciences, 6120 Executive Blvd, Rockville, MD 20852 (e-mail: <email>royang@mail.nih.gov</email>
).</corresp>
</author-notes>
<pub-date pub-type="ppub"><day>02</day>
<month>2</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="epub"><day>29</day>
<month>12</month>
<year>2010</year>
</pub-date>
<volume>103</volume>
<issue>3</issue>
<fpage>250</fpage>
<lpage>263</lpage>
<history><date date-type="received"><day>13</day>
<month>5</month>
<year>2010</year>
</date>
<date date-type="rev-recd"><day>22</day>
<month>11</month>
<year>2010</year>
</date>
<date date-type="accepted"><day>23</day>
<month>11</month>
<year>2010</year>
</date>
</history>
<permissions><copyright-statement>© The Author 2010. Published by Oxford University Press.</copyright-statement>
<copyright-year>2011</copyright-year>
</permissions>
<abstract><sec><title>Background</title>
<p>Previous studies have suggested that breast cancer risk factors are associated with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors.</p>
</sec>
<sec><title>Methods</title>
<p>We pooled tumor marker and epidemiological risk factor data from 35 568 invasive breast cancer case patients from 34 studies participating in the Breast Cancer Association Consortium. Logistic regression models were used in case–case analyses to estimate associations between epidemiological risk factors and tumor subtypes, and case–control analyses to estimate associations between epidemiological risk factors and the risk of developing specific tumor subtypes in 12 population-based studies. All statistical tests were two-sided.</p>
</sec>
<sec><title>Results</title>
<p>In case–case analyses, of the epidemiological risk factors examined, early age at menarche (≤12 years) was less frequent in case patients with PR<sup>−</sup>
than PR<sup>+</sup>
tumors (<italic>P</italic>
= .001). Nulliparity (<italic>P</italic>
= 3 × 10<sup>−6</sup>
) and increasing age at first birth (<italic>P</italic>
= 2 × 10<sup>−9</sup>
) were less frequent in ER<sup>−</sup>
than in ER<sup>+</sup>
tumors. Obesity (body mass index [BMI] ≥ 30 kg/m<sup>2</sup>
) in younger women (≤50 years) was more frequent in ER<sup>−</sup>
/PR<sup>−</sup>
than in ER<sup>+</sup>
/PR<sup>+</sup>
tumors (<italic>P</italic>
= 1 × 10<sup>−7</sup>
), whereas obesity in older women (>50 years) was less frequent in PR<sup>−</sup>
than in PR<sup>+</sup>
tumors (<italic>P</italic>
= 6 × 10<sup>−4</sup>
). The triple-negative (ER<sup>−</sup>
/PR<sup>−</sup>
/HER2<sup>−</sup>
) or core basal phenotype (CBP; triple-negative and cytokeratins [CK]5/6<sup>+</sup>
and/or epidermal growth factor receptor [EGFR]<sup>+</sup>
) accounted for much of the heterogeneity in parity-related variables and BMI in younger women. Case–control analyses showed that nulliparity, increasing age at first birth, and obesity in younger women showed the expected associations with the risk of ER<sup>+</sup>
or PR<sup>+</sup>
tumors but not triple-negative (nulliparity vs parity, odds ratio [OR] = 0.94, 95% confidence interval [CI] = 0.75 to 1.19, <italic>P</italic>
= .61; 5-year increase in age at first full-term birth, OR = 0.95, 95% CI = 0.86 to 1.05, <italic>P</italic>
= .34; obesity in younger women, OR = 1.36, 95% CI = 0.95 to 1.94, <italic>P</italic>
= .09) or CBP tumors.</p>
</sec>
<sec><title>Conclusions</title>
<p>This study shows that reproductive factors and BMI are most clearly associated with hormone receptor–positive tumors and suggest that triple-negative or CBP tumors may have distinct etiology.</p>
</sec>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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