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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Identification and characterization of novel associations in the <italic>CASP8/ALS2CR12</italic> region on chromosome 2 with breast cancer risk</title><author><name sortKey="Lin, Wei Yu" sort="Lin, Wei Yu" uniqKey="Lin W" first="Wei-Yu" last="Lin">Wei-Yu Lin</name><affiliation><nlm:aff id="af1"><addr-line>Department of Oncology</addr-line>,<institution>University of Sheffield Medical School</institution>,<addr-line>Sheffield S10 2RX</addr-line>,<country>UK</country></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Neurosurgery</addr-line>,<institution>Chang Gung Memorial Hospital</institution>,<addr-line>Taoyuan County 333</addr-line>,<country>Taiwan</country></nlm:aff></affiliation></author><author><name sortKey="Camp, Nicola J" sort="Camp, Nicola J" uniqKey="Camp N" first="Nicola J." last="Camp">Nicola J. Camp</name><affiliation><nlm:aff id="af3"><addr-line>Department of Internal Medicine</addr-line>,<institution>University of Utah School of Medicine</institution>,<addr-line>Salt Lake City, UT 84108-1266</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Ghoussaini, Maya" sort="Ghoussaini, Maya" uniqKey="Ghoussaini M" first="Maya" last="Ghoussaini">Maya Ghoussaini</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line></nlm:aff></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation><nlm:aff id="af6"><addr-line>Department of Genetics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="af8"><addr-line>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation><nlm:aff id="af8"><addr-line>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="af9"><addr-line>Department of Pathology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stone, Jennifer" sort="Stone, Jennifer" uniqKey="Stone J" first="Jennifer" last="Stone">Jennifer Stone</name><affiliation><nlm:aff id="af10"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="af13"><addr-line>Netherlands Cancer Institute</addr-line>,<institution>Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam 1066 CX</addr-line>,<country>the Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation><nlm:aff id="af13"><addr-line>Netherlands Cancer Institute</addr-line>,<institution>Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam 1066 CX</addr-line>,<country>the Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Van T Veer, Laura J" sort="Van T Veer, Laura J" uniqKey="Van T Veer L" first="Laura J." last="Van'T Veer">Laura J. Van'T Veer</name><affiliation><nlm:aff id="af13"><addr-line>Netherlands Cancer Institute</addr-line>,<institution>Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam 1066 CX</addr-line>,<country>the Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Th Rutgers, Emiel J" sort="Th Rutgers, Emiel J" uniqKey="Th Rutgers E" first="Emiel J." last="Th Rutgers">Emiel J. Th Rutgers</name><affiliation><nlm:aff id="af13"><addr-line>Netherlands Cancer Institute</addr-line>,<institution>Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam 1066 CX</addr-line>,<country>the Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation><nlm:aff id="af14"><addr-line>Division of Health Sciences, Warwick Medical School</addr-line>,<institution>Warwick University</institution>,<addr-line>Coventry CV4 7AL</addr-line>,<country>UK</country></nlm:aff></affiliation><affiliation><nlm:aff id="af15"><addr-line>Institute of Population Health</addr-line>,<institution>University of Manchester</institution>,<addr-line>Manchester M13 9QQ</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name><affiliation><nlm:aff id="af14"><addr-line>Division of Health Sciences, Warwick Medical School</addr-line>,<institution>Warwick University</institution>,<addr-line>Coventry CV4 7AL</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Stewart Brown, Sarah" sort="Stewart Brown, Sarah" uniqKey="Stewart Brown S" first="Sarah" last="Stewart-Brown">Sarah Stewart-Brown</name><affiliation><nlm:aff id="af14"><addr-line>Division of Health Sciences, Warwick Medical School</addr-line>,<institution>Warwick University</institution>,<addr-line>Coventry CV4 7AL</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Siriwanarangsan, Pornthep" sort="Siriwanarangsan, Pornthep" uniqKey="Siriwanarangsan P" first="Pornthep" last="Siriwanarangsan">Pornthep Siriwanarangsan</name><affiliation><nlm:aff id="af16"><addr-line>Ministry of Public Health, Nonthaburi 11000</addr-line>,<country>Thailand</country></nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="af17"><addr-line>University Breast Center Franconia, Department of Gynecology and Obstetrics</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af19"><addr-line>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology</addr-line>,<institution>University of California</institution>,<addr-line>Los Angeles, CA 90095</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Haeberle, Lothar" sort="Haeberle, Lothar" uniqKey="Haeberle L" first="Lothar" last="Haeberle">Lothar Haeberle</name><affiliation><nlm:aff id="af17"><addr-line>University Breast Center Franconia, Department of Gynecology and Obstetrics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation><nlm:aff id="af18"><addr-line>Institute of Human Genetics</addr-line>,<institution>University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg</institution>,<addr-line>Erlangen D-91054</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="af17"><addr-line>University Breast Center Franconia, Department of Gynecology and Obstetrics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="af20"><addr-line>Non-communicable Disease Epidemiology Department</addr-line>,<institution>London School of Hygiene and Tropical Medicine</institution>,<addr-line>London WC1E 7HT</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><affiliation><nlm:aff id="af20"><addr-line>Non-communicable Disease Epidemiology Department</addr-line>,<institution>London School of Hygiene and Tropical Medicine</institution>,<addr-line>London WC1E 7HT</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="af21"><addr-line>Breakthrough Breast Cancer Research Centre</addr-line></nlm:aff></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation><nlm:aff id="af21"><addr-line>Breakthrough Breast Cancer Research Centre</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name><affiliation><nlm:aff id="af24"><addr-line>Division of Cancer Studies</addr-line>,<institution>Kings College London</institution>,<institution>Guy's Hospital</institution>,<addr-line>London SE1 9RT</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Cheng, Timothy" sort="Cheng, Timothy" uniqKey="Cheng T" first="Timothy" last="Cheng">Timothy Cheng</name><affiliation><nlm:aff id="af25"><addr-line>Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford OX3 7BN</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation><nlm:aff id="af25"><addr-line>Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford OX3 7BN</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Kerin, Michael J" sort="Kerin, Michael J" uniqKey="Kerin M" first="Michael J." last="Kerin">Michael J. Kerin</name><affiliation><nlm:aff id="af26"><addr-line>School of Medicine, National University of Ireland</addr-line>,<country>Galway, Ireland</country></nlm:aff></affiliation></author><author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name><affiliation><nlm:aff id="af26"><addr-line>School of Medicine, National University of Ireland</addr-line>,<country>Galway, Ireland</country></nlm:aff></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marmé">Frederik Marmé</name><affiliation><nlm:aff id="af27"><addr-line>Department of Obstetrics and Gynecology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af28"><addr-line>National Center for Tumor Diseases</addr-line>,<institution>University of Heidelberg</institution>,<addr-line>Heidelberg 69117</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Surowy, Harald M" sort="Surowy, Harald M" uniqKey="Surowy H" first="Harald M." last="Surowy">Harald M. Surowy</name><affiliation><nlm:aff id="af27"><addr-line>Department of Obstetrics and Gynecology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af29"><addr-line>Molecular Epidemiology Group</addr-line></nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="af27"><addr-line>Department of Obstetrics and Gynecology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af29"><addr-line>Molecular Epidemiology Group</addr-line></nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation><nlm:aff id="af35"><addr-line>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health)</addr-line>,<institution>U1018, Environmental Epidemiology of Cancer</institution>,<addr-line>Villejuif 94807</addr-line>,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af36"><institution>University Paris-Sud, UMRS 1018</institution>,<addr-line>Villejuif 94807</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation><nlm:aff id="af35"><addr-line>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health)</addr-line>,<institution>U1018, Environmental Epidemiology of Cancer</institution>,<addr-line>Villejuif 94807</addr-line>,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af36"><institution>University Paris-Sud, UMRS 1018</institution>,<addr-line>Villejuif 94807</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Menegaux, Florence" sort="Menegaux, Florence" uniqKey="Menegaux F" first="Florence" last="Menegaux">Florence Menegaux</name><affiliation><nlm:aff id="af35"><addr-line>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health)</addr-line>,<institution>U1018, Environmental Epidemiology of Cancer</institution>,<addr-line>Villejuif 94807</addr-line>,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af36"><institution>University Paris-Sud, UMRS 1018</institution>,<addr-line>Villejuif 94807</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Mulot, Claire" sort="Mulot, Claire" uniqKey="Mulot C" first="Claire" last="Mulot">Claire Mulot</name><affiliation><nlm:aff id="af37"><institution>Université Paris Sorbonne Cité, UMR-S775 Inserm</institution>,<addr-line>Paris 75015</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="af38"><addr-line>Copenhagen General Population Study</addr-line>,<institution>Herlev Hospital</institution>,<addr-line>2730 Herlev, Copenhagen</addr-line>,<country>Denmark</country></nlm:aff></affiliation><affiliation><nlm:aff id="af39"><addr-line>Department of Clinical Biochemistry</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af41"><addr-line>Faculty of Health and Medical Sciences</addr-line>,<institution>University of Copenhagen</institution>,<addr-line>Copenhagen 2200</addr-line>,<country>Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation><nlm:aff id="af38"><addr-line>Copenhagen General Population Study</addr-line>,<institution>Herlev Hospital</institution>,<addr-line>2730 Herlev, Copenhagen</addr-line>,<country>Denmark</country></nlm:aff></affiliation><affiliation><nlm:aff id="af39"><addr-line>Department of Clinical Biochemistry</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af41"><addr-line>Faculty of Health and Medical Sciences</addr-line>,<institution>University of Copenhagen</institution>,<addr-line>Copenhagen 2200</addr-line>,<country>Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Nielsen, Sune F" sort="Nielsen, Sune F" uniqKey="Nielsen S" first="Sune F." last="Nielsen">Sune F. Nielsen</name><affiliation><nlm:aff id="af38"><addr-line>Copenhagen General Population Study</addr-line>,<institution>Herlev Hospital</institution>,<addr-line>2730 Herlev, Copenhagen</addr-line>,<country>Denmark</country></nlm:aff></affiliation><affiliation><nlm:aff id="af39"><addr-line>Department of Clinical Biochemistry</addr-line></nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="af40"><addr-line>Department of Breast Surgery</addr-line>,<institution>Herlev Hospital, Copenhagen University Hospital</institution>,<addr-line>Copenhagen 2100</addr-line>,<country>Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="af42"><addr-line>Human Genetics Group, Human Cancer Genetics Program</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af44"><institution>Centro de Investigación en Red de Enfermedades Raras (CIBERER)</institution>,<addr-line>Valencia 28029</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Zamora, M Pilar" sort="Zamora, M Pilar" uniqKey="Zamora M" first="M. Pilar" last="Zamora">M. Pilar Zamora</name><affiliation><nlm:aff id="af45"><addr-line>Servicio de Oncología Médica</addr-line>,<institution>Hospital Universitario La Paz</institution>,<addr-line>Madrid 28046</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Arias Perez, Jose Ignacio" sort="Arias Perez, Jose Ignacio" uniqKey="Arias Perez J" first="Jose Ignacio" last="Arias Perez">Jose Ignacio Arias Perez</name><affiliation><nlm:aff id="af46"><addr-line>Servicio de Cirugía General y Especialidades</addr-line></nlm:aff></affiliation></author><author><name sortKey="Menendez, Primitiva" sort="Menendez, Primitiva" uniqKey="Menendez P" first="Primitiva" last="Menéndez">Primitiva Menéndez</name><affiliation><nlm:aff id="af47"><addr-line>Servicio de Anatomía Patológica</addr-line>,<institution>Hospital Monte Naranco</institution>,<addr-line>Oviedo 33012</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name><affiliation><nlm:aff id="af43"><addr-line>Human Genotyping-CEGEN Unit, Human Cancer Genetics Program</addr-line>,<institution>Spanish National Cancer Research Centre (CNIO)</institution>,<addr-line>Madrid E-28029</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Pita, Guillermo" sort="Pita, Guillermo" uniqKey="Pita G" first="Guillermo" last="Pita">Guillermo Pita</name><affiliation><nlm:aff id="af43"><addr-line>Human Genotyping-CEGEN Unit, Human Cancer Genetics Program</addr-line>,<institution>Spanish National Cancer Research Centre (CNIO)</institution>,<addr-line>Madrid E-28029</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Alonso, M Rosario" sort="Alonso, M Rosario" uniqKey="Alonso M" first="M. Rosario" last="Alonso">M. Rosario Alonso</name><affiliation><nlm:aff id="af43"><addr-line>Human Genotyping-CEGEN Unit, Human Cancer Genetics Program</addr-line>,<institution>Spanish National Cancer Research Centre (CNIO)</institution>,<addr-line>Madrid E-28029</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Alvarez, Nuria" sort="Alvarez, Nuria" uniqKey="Alvarez N" first="Nuria" last="Álvarez">Nuria Álvarez</name><affiliation><nlm:aff id="af43"><addr-line>Human Genotyping-CEGEN Unit, Human Cancer Genetics Program</addr-line>,<institution>Spanish National Cancer Research Centre (CNIO)</institution>,<addr-line>Madrid E-28029</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Herrero, Daniel" sort="Herrero, Daniel" uniqKey="Herrero D" first="Daniel" last="Herrero">Daniel Herrero</name><affiliation><nlm:aff id="af43"><addr-line>Human Genotyping-CEGEN Unit, Human Cancer Genetics Program</addr-line>,<institution>Spanish National Cancer Research Centre (CNIO)</institution>,<addr-line>Madrid E-28029</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="af48"><addr-line>Department of Epidemiology</addr-line>,<institution>University of California Irvine</institution>,<addr-line>Irvine, CA 92697</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="af30"><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af49"><institution>German Cancer Consortium (DKTK)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Dieffenbach, Aida Karina" sort="Dieffenbach, Aida Karina" uniqKey="Dieffenbach A" first="Aida Karina" last="Dieffenbach">Aida Karina Dieffenbach</name><affiliation><nlm:aff id="af30"><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af49"><institution>German Cancer Consortium (DKTK)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="af30"><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name><affiliation><nlm:aff id="af50"><institution>Saarland Cancer Registry</institution>,<addr-line>Saarbrücken 66024</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="af51"><addr-line>Division of Gynaecology and Obstetrics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lichtner, Peter" sort="Lichtner, Peter" uniqKey="Lichtner P" first="Peter" last="Lichtner">Peter Lichtner</name><affiliation><nlm:aff id="af52"><addr-line>Insitute of Human Genetics</addr-line>,<institution>Technische Universität München</institution>,<addr-line>Munich D-80333</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="af53"><addr-line>Center for Hereditary Breast and Ovarian Cancer</addr-line>,<institution>Center for Integrated Oncology (CIO) and Center for Molecular Medicine Cologne (CMMC)</institution>,<addr-line>Medical Faculty, University of Cologne and University Hospital Cologne, 50932 Cologne</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name><affiliation><nlm:aff id="af54"><institution>Max Planck Institute of Psychiatry</institution>,<addr-line>Munich 80804</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="af55"><institution>Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology</institution>,<addr-line>Stuttgart 70376</addr-line>,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="af56"><institution>University of Tübingen</institution>,<addr-line>Tübingen 72074</addr-line>,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="af31"><addr-line>German Cancer Consortium (DKTK)</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><affiliation><nlm:aff id="af57"><addr-line>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance</addr-line>,<institution>Institute of the Ruhr-University Bochum (IPA)</institution>,<addr-line>Bochum D-44789</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name><affiliation><nlm:aff id="af58"><addr-line>Department of Internal Medicine</addr-line>,<institution>Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus</institution>,<addr-line>Bonn 53113</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Tessier, Daniel C" sort="Tessier, Daniel C" uniqKey="Tessier D" first="Daniel C." last="Tessier">Daniel C. Tessier</name><affiliation><nlm:aff id="af61"><institution>Centre D'innovation Génome Québec et Université McGill</institution>,<addr-line>Montréal, QC</addr-line>,<country>Canada</country><addr-line>H3A 0G1</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vincent, Daniel" sort="Vincent, Daniel" uniqKey="Vincent D" first="Daniel" last="Vincent">Daniel Vincent</name><affiliation><nlm:aff id="af61"><institution>Centre D'innovation Génome Québec et Université McGill</institution>,<addr-line>Montréal, QC</addr-line>,<country>Canada</country><addr-line>H3A 0G1</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bacot, Francois" sort="Bacot, Francois" uniqKey="Bacot F" first="Francois" last="Bacot">Francois Bacot</name><affiliation><nlm:aff id="af61"><institution>Centre D'innovation Génome Québec et Université McGill</institution>,<addr-line>Montréal, QC</addr-line>,<country>Canada</country><addr-line>H3A 0G1</addr-line></nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="af62"><addr-line>Department of Obstetrics and Gynecology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af65"><institution>Helsinki University Central Hospital</institution>,<addr-line>Helsinki 00029</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="af63"><addr-line>Department of Clinical Genetics</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af65"><institution>Helsinki University Central Hospital</institution>,<addr-line>Helsinki 00029</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation><nlm:aff id="af64"><addr-line>Department of Oncology, University of Helsinki</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af65"><institution>Helsinki University Central Hospital</institution>,<addr-line>Helsinki 00029</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Khan, Sofia" sort="Khan, Sofia" uniqKey="Khan S" first="Sofia" last="Khan">Sofia Khan</name><affiliation><nlm:aff id="af62"><addr-line>Department of Obstetrics and Gynecology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af65"><institution>Helsinki University Central Hospital</institution>,<addr-line>Helsinki 00029</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Matsuo, Keitaro" sort="Matsuo, Keitaro" uniqKey="Matsuo K" first="Keitaro" last="Matsuo">Keitaro Matsuo</name><affiliation><nlm:aff id="af66"><addr-line>Department of Preventive Medicine</addr-line>,<institution>Kyushu University Faculty of Medical Sciences</institution>,<addr-line>Fukuoka 812-8582</addr-line>,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Ito, Hidemi" sort="Ito, Hidemi" uniqKey="Ito H" first="Hidemi" last="Ito">Hidemi Ito</name><affiliation><nlm:aff id="af67"><addr-line>Division of Epidemiology and Prevention</addr-line>,<institution>Aichi Cancer Center Research Institute</institution>,<addr-line>Nagoya 464-8681</addr-line>,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Iwata, Hiroji" sort="Iwata, Hiroji" uniqKey="Iwata H" first="Hiroji" last="Iwata">Hiroji Iwata</name><affiliation><nlm:aff id="af68"><addr-line>Department of Breast Oncology</addr-line>,<institution>Aichi Cancer Center Hospital</institution>,<addr-line>Nagoya 464-8681</addr-line>,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Horio, Akiyo" sort="Horio, Akiyo" uniqKey="Horio A" first="Akiyo" last="Horio">Akiyo Horio</name><affiliation><nlm:aff id="af68"><addr-line>Department of Breast Oncology</addr-line>,<institution>Aichi Cancer Center Hospital</institution>,<addr-line>Nagoya 464-8681</addr-line>,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name><affiliation><nlm:aff id="af69"><addr-line>Department of Obstetrics and Gynaecology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af70"><addr-line>Department of Radiation Oncology</addr-line>,<institution>Hannover Medical School</institution>,<addr-line>Hannover 30625</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Antonenkova, Natalia N" sort="Antonenkova, Natalia N" uniqKey="Antonenkova N" first="Natalia N." last="Antonenkova">Natalia N. Antonenkova</name><affiliation><nlm:aff id="af71"><institution>N.N. Alexandrov Research Institute of Oncology and Medical Radiology</institution>,<addr-line>Minsk 223040</addr-line>,<country>Belarus</country></nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="af69"><addr-line>Department of Obstetrics and Gynaecology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff id="af72"><addr-line>Department of Molecular Medicine and Surgery</addr-line></nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation><nlm:aff id="af73"><addr-line>Department of Oncology–Pathology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff id="af75"><addr-line>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine</addr-line> and Cancer Center of Eastern Finland</nlm:aff></affiliation><affiliation><nlm:aff id="af77"><addr-line>Imaging Center, Department of Clinical Pathology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name><affiliation><nlm:aff id="af76"><addr-line>School of Medicine, Institute of Clinical Medicine, Oncology</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio 70210</addr-line>,<country>Finland</country></nlm:aff></affiliation><affiliation><nlm:aff id="af78"><addr-line>Cancer Center</addr-line>,<institution>Kuopio University Hospital</institution>,<addr-line>Kuopio 70029</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff id="af75"><addr-line>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine</addr-line> and Cancer Center of Eastern Finland</nlm:aff></affiliation><affiliation><nlm:aff id="af77"><addr-line>Imaging Center, Department of Clinical Pathology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M." last="Hartikainen">Jaana M. Hartikainen</name><affiliation><nlm:aff id="af75"><addr-line>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine</addr-line> and Cancer Center of Eastern Finland</nlm:aff></affiliation><affiliation><nlm:aff id="af77"><addr-line>Imaging Center, Department of Clinical Pathology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wu, Anna H" sort="Wu, Anna H" uniqKey="Wu A" first="Anna H." last="Wu">Anna H. Wu</name><affiliation><nlm:aff id="af80"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles, CA 90033</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Tseng, Chiu Chen" sort="Tseng, Chiu Chen" uniqKey="Tseng C" first="Chiu-Chen" last="Tseng">Chiu-Chen Tseng</name><affiliation><nlm:aff id="af80"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles, CA 90033</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Van Den Berg, David" sort="Van Den Berg, David" uniqKey="Van Den Berg D" first="David" last="Van Den Berg">David Van Den Berg</name><affiliation><nlm:aff id="af80"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles, CA 90033</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Stram, Daniel O" sort="Stram, Daniel O" uniqKey="Stram D" first="Daniel O." last="Stram">Daniel O. Stram</name><affiliation><nlm:aff id="af80"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles, CA 90033</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Neven, Patrick" sort="Neven, Patrick" uniqKey="Neven P" first="Patrick" last="Neven">Patrick Neven</name><affiliation><nlm:aff id="af81"><institution>University Hospital Gashuisberg</institution>,<addr-line>Leuven 3000</addr-line>,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Wauters, Els" sort="Wauters, Els" uniqKey="Wauters E" first="Els" last="Wauters">Els Wauters</name><affiliation><nlm:aff id="af82"><addr-line>Vesalius Research Center (VRC), VIB, Leuven 3000</addr-line>,<country>Belgium</country></nlm:aff></affiliation><affiliation><nlm:aff id="af83"><addr-line>Department of Oncology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wildiers, Hans" sort="Wildiers, Hans" uniqKey="Wildiers H" first="Hans" last="Wildiers">Hans Wildiers</name><affiliation><nlm:aff id="af85"><addr-line>Department of General Medical Oncology</addr-line>,<institution>University Hospitals Leuven</institution>,<addr-line>Leuven 3000</addr-line>,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="af82"><addr-line>Vesalius Research Center (VRC), VIB, Leuven 3000</addr-line>,<country>Belgium</country></nlm:aff></affiliation><affiliation><nlm:aff id="af84"><addr-line>Laboratory for Translational Genetics, Department of Oncology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="af32"><addr-line>Division of Cancer Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="af32"><addr-line>Division of Cancer Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Seibold, Petra" sort="Seibold, Petra" uniqKey="Seibold P" first="Petra" last="Seibold">Petra Seibold</name><affiliation><nlm:aff id="af32"><addr-line>Division of Cancer Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="af86"><addr-line>Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology</addr-line>,<institution>University Clinic Hamburg-Eppendorf</institution>,<addr-line>Hamburg D-20246</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="af87"><addr-line>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="af89"><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>,<addr-line>Milan 20139</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="af88"><addr-line>Unit of Medical Genetics, Department of Preventive and Predictive Medicine</addr-line>,<institution>Fondazione IRCCS Istituto Nazionale dei Tumori (INT)</institution>,<addr-line>Milan 20133</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name><affiliation><nlm:aff id="af90"><addr-line>Division of Cancer Prevention and Genetics</addr-line>,<institution>Istituto Europeo di Oncologia (IEO)</institution>,<addr-line>Milan 20141</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="af91"><addr-line>Department of Laboratory Medicine and Pathology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><nlm:aff id="af91"><addr-line>Department of Laboratory Medicine and Pathology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name><affiliation><nlm:aff id="af92"><addr-line>Department of Health Sciences Research</addr-line>,<institution>Mayo Clinic</institution>,<addr-line>Rochester, MN 55905</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Purrington, Kristen" sort="Purrington, Kristen" uniqKey="Purrington K" first="Kristen" last="Purrington">Kristen Purrington</name><affiliation><nlm:aff id="af93"><addr-line>Karmanos Cancer Center, Detroit, MI 48201</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="af8"><addr-line>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af94"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>Cancer Council Victoria</institution>,<addr-line>Melbourne, VIC 3004</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="af8"><addr-line>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af94"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>Cancer Council Victoria</institution>,<addr-line>Melbourne, VIC 3004</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name><affiliation><nlm:aff id="af95"><addr-line>Anatomical Pathology</addr-line>,<institution>The Alfred Hospital</institution>,<addr-line>Melbourne, VIC 3004</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="af80"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles, CA 90033</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation><nlm:aff id="af80"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles, CA 90033</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Schumacher, Fredrick" sort="Schumacher, Fredrick" uniqKey="Schumacher F" first="Fredrick" last="Schumacher">Fredrick Schumacher</name><affiliation><nlm:aff id="af80"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles, CA 90033</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="af96"><addr-line>Epidemiology Program</addr-line>,<institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI 96813</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="af97"><institution>Centre Hospitalier Universitaire de Québec Research Centre and Laval University</institution>,<addr-line>Quebec City, QC</addr-line>,<country>Canada</country><addr-line>G1V 4G2</addr-line></nlm:aff></affiliation></author><author><name sortKey="Goldberg, Mark S" sort="Goldberg, Mark S" uniqKey="Goldberg M" first="Mark S." last="Goldberg">Mark S. Goldberg</name><affiliation><nlm:aff id="af98"><addr-line>Department of Medicine</addr-line>,<institution>McGill University</institution>,<addr-line>Montreal, QC</addr-line>,<country>Canada</country><addr-line>H3A 0G4</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af99"><addr-line>Division of Clinical Epidemiology</addr-line>,<institution>McGill University Health Centre, Royal Victoria Hospital</institution>,<addr-line>Montreal, QC</addr-line>,<country>Canada</country><addr-line>H3A 1A1</addr-line></nlm:aff></affiliation></author><author><name sortKey="Labreche, France" sort="Labreche, France" uniqKey="Labreche F" first="France" last="Labrèche">France Labrèche</name><affiliation><nlm:aff id="af100"><addr-line>Départements de Santé Environnementale et Santé au Travail et de Médecine Sociale et Préventive, École de Santé Publique</addr-line>,<institution>Université de Montréal</institution>,<addr-line>Montreal, QC</addr-line>,<country>Canada</country><addr-line>H3T 1J4</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name><affiliation><nlm:aff id="af97"><institution>Centre Hospitalier Universitaire de Québec Research Centre and Laval University</institution>,<addr-line>Quebec City, QC</addr-line>,<country>Canada</country><addr-line>G1V 4G2</addr-line></nlm:aff></affiliation></author><author><name sortKey="Teo, Soo Hwang" sort="Teo, Soo Hwang" uniqKey="Teo S" first="Soo Hwang" last="Teo">Soo Hwang Teo</name><affiliation><nlm:aff id="af101"><addr-line>Cancer Research Initiatives Foundation</addr-line>,<institution>Sime Darby Medical Centre</institution>,<addr-line>Subang Jaya, Selangor</addr-line>,<country>Malaysia</country></nlm:aff></affiliation><affiliation><nlm:aff id="af102"><addr-line>Breast Cancer Research Unit</addr-line>,<institution>University Malaya Cancer Research Institute, University Malaya Medical Centre</institution>,<addr-line>Kuala Lumpur 50603</addr-line>,<country>Malaysia</country></nlm:aff></affiliation></author><author><name sortKey="Yip, Cheng Har" sort="Yip, Cheng Har" uniqKey="Yip C" first="Cheng Har" last="Yip">Cheng Har Yip</name><affiliation><nlm:aff id="af102"><addr-line>Breast Cancer Research Unit</addr-line>,<institution>University Malaya Cancer Research Institute, University Malaya Medical Centre</institution>,<addr-line>Kuala Lumpur 50603</addr-line>,<country>Malaysia</country></nlm:aff></affiliation></author><author><name sortKey="Hassan, Norhashimah" sort="Hassan, Norhashimah" uniqKey="Hassan N" first="Norhashimah" last="Hassan">Norhashimah Hassan</name><affiliation><nlm:aff id="af101"><addr-line>Cancer Research Initiatives Foundation</addr-line>,<institution>Sime Darby Medical Centre</institution>,<addr-line>Subang Jaya, Selangor</addr-line>,<country>Malaysia</country></nlm:aff></affiliation><affiliation><nlm:aff id="af102"><addr-line>Breast Cancer Research Unit</addr-line>,<institution>University Malaya Cancer Research Institute, University Malaya Medical Centre</institution>,<addr-line>Kuala Lumpur 50603</addr-line>,<country>Malaysia</country></nlm:aff></affiliation></author><author><name sortKey="Vithana, Eranga Nishanthie" sort="Vithana, Eranga Nishanthie" uniqKey="Vithana E" first="Eranga Nishanthie" last="Vithana">Eranga Nishanthie Vithana</name><affiliation><nlm:aff id="af103"><addr-line>Singapore Eye Research Institute</addr-line>,<institution>National University of Singapore</institution>,<addr-line>Singapore 119077</addr-line>,<country>Singapore</country></nlm:aff></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation><nlm:aff id="af104"><addr-line>Department of Genetics, Institute for Cancer Research</addr-line>,<institution>Oslo University Hospital, Radiumhospitalet</institution>,<addr-line>Oslo 0372</addr-line>,<country>Norway</country></nlm:aff></affiliation><affiliation><nlm:aff id="af105"><addr-line>Faculty of Medicine (Faculty Division Ahus)</addr-line>,<institution>University of Oslo (UiO)</institution>,<addr-line>Oslo 0316</addr-line>,<country>Norway</country></nlm:aff></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:aff id="af106"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center</addr-line>,<institution>Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN 37232</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Deming Halverson, Sandra" sort="Deming Halverson, Sandra" uniqKey="Deming Halverson S" first="Sandra" last="Deming-Halverson">Sandra Deming-Halverson</name><affiliation><nlm:aff id="af106"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center</addr-line>,<institution>Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN 37232</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Shrubsole, Martha J" sort="Shrubsole, Martha J" uniqKey="Shrubsole M" first="Martha J." last="Shrubsole">Martha J. Shrubsole</name><affiliation><nlm:aff id="af106"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center</addr-line>,<institution>Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN 37232</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Long, Jirong" sort="Long, Jirong" uniqKey="Long J" first="Jirong" last="Long">Jirong Long</name><affiliation><nlm:aff id="af106"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center</addr-line>,<institution>Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN 37232</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="af107"><addr-line>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, Northern Finland Laboratory Centre NordLab</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation><nlm:aff id="af107"><addr-line>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, Northern Finland Laboratory Centre NordLab</addr-line></nlm:aff></affiliation></author><author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name><affiliation><nlm:aff id="af108"><addr-line>Department of Oncology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kauppila, Saila" sort="Kauppila, Saila" uniqKey="Kauppila S" first="Saila" last="Kauppila">Saila Kauppila</name><affiliation><nlm:aff id="af109"><addr-line>Department of Pathology</addr-line>,<institution>Oulu University Hospital</institution>,<institution>University of Oulu</institution>,<addr-line>Oulu 90570</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="af110"><addr-line>Ontario Cancer Genetics Network</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af113"><addr-line>Department of Molecular Genetics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name><affiliation><nlm:aff id="af111"><addr-line>Prosserman Centre for Health Research</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af114"><addr-line>Division of Epidemiology, Dalla Lana School of Public Health</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto, ON</addr-line>,<country>Canada</country><addr-line>M5S 2J7</addr-line></nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="af110"><addr-line>Ontario Cancer Genetics Network</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tchatchou, Sandrine" sort="Tchatchou, Sandrine" uniqKey="Tchatchou S" first="Sandrine" last="Tchatchou">Sandrine Tchatchou</name><affiliation><nlm:aff id="af112"><institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto, ON</addr-line>,<country>Canada</country><addr-line>M5G 1X5</addr-line></nlm:aff></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:aff id="af115"><addr-line>Department of Human Genetics & Department of Pathology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tollenaar, Robert A E M" sort="Tollenaar, Robert A E M" uniqKey="Tollenaar R" first="Robert A. E. M." last="Tollenaar">Robert A. E. M. Tollenaar</name><affiliation><nlm:aff id="af116"><addr-line>Department of Surgical Oncology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name><affiliation><nlm:aff id="af118"><addr-line>Family Cancer Clinic, Department of Medical Oncology</addr-line>,<institution>Erasmus MC Cancer Institute</institution><addr-line>Rotterdam 3075 EA</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Van Asperen, Christi J" sort="Van Asperen, Christi J" uniqKey="Van Asperen C" first="Christi J." last="Van Asperen">Christi J. Van Asperen</name><affiliation><nlm:aff id="af117"><addr-line>Department of Clinical Genetics</addr-line>,<institution>Leiden University Medical Center</institution>,<addr-line>Leiden 2300 RC</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation><nlm:aff id="af22"><addr-line>Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af119"><addr-line>Division of Genetics and Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name><affiliation><nlm:aff id="af122"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD 20850</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><affiliation><nlm:aff id="af123"><addr-line>Department of Cancer Epidemiology and Prevention</addr-line>,<institution>M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology</institution>,<addr-line>Warsaw 02-781</addr-line>,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Brinton, Louise" sort="Brinton, Louise" uniqKey="Brinton L" first="Louise" last="Brinton">Louise Brinton</name><affiliation><nlm:aff id="af122"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD 20850</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="af74"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm 17177</addr-line>,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name><affiliation><nlm:aff id="af74"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm 17177</addr-line>,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Eriksson, Mikael" sort="Eriksson, Mikael" uniqKey="Eriksson M" first="Mikael" last="Eriksson">Mikael Eriksson</name><affiliation><nlm:aff id="af74"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm 17177</addr-line>,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Brand, Judith S" sort="Brand, Judith S" uniqKey="Brand J" first="Judith S." last="Brand">Judith S. Brand</name><affiliation><nlm:aff id="af74"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm 17177</addr-line>,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name><affiliation><nlm:aff id="af118"><addr-line>Family Cancer Clinic, Department of Medical Oncology</addr-line>,<institution>Erasmus MC Cancer Institute</institution><addr-line>Rotterdam 3075 EA</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation><nlm:aff id="af118"><addr-line>Family Cancer Clinic, Department of Medical Oncology</addr-line>,<institution>Erasmus MC Cancer Institute</institution><addr-line>Rotterdam 3075 EA</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Van Den Ouweland, Ans M W" sort="Van Den Ouweland, Ans M W" uniqKey="Van Den Ouweland A" first="Ans M. W." last="Van Den Ouweland">Ans M. W. Van Den Ouweland</name><affiliation><nlm:aff id="af124"><addr-line>Department of Clinical Genetics</addr-line>,<institution>Erasmus University Medical Center</institution>,<addr-line>Rotterdam 3075 EA</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Jager, Agnes" sort="Jager, Agnes" uniqKey="Jager A" first="Agnes" last="Jager">Agnes Jager</name><affiliation><nlm:aff id="af118"><addr-line>Family Cancer Clinic, Department of Medical Oncology</addr-line>,<institution>Erasmus MC Cancer Institute</institution><addr-line>Rotterdam 3075 EA</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation><nlm:aff id="af126"><addr-line>Shanghai Center for Disease Control and Prevention, Shanghai 200336</addr-line>,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation><nlm:aff id="af125"><addr-line>Human Genetics Division</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore 138672</addr-line>,<country>Singapore</country></nlm:aff></affiliation></author><author><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name><affiliation><nlm:aff id="af74"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm 17177</addr-line>,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation><nlm:aff id="af106"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center</addr-line>,<institution>Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN 37232</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Lu, Wei" sort="Lu, Wei" uniqKey="Lu W" first="Wei" last="Lu">Wei Lu</name><affiliation><nlm:aff id="af126"><addr-line>Shanghai Center for Disease Control and Prevention, Shanghai 200336</addr-line>,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Gao, Yu Tang" sort="Gao, Yu Tang" uniqKey="Gao Y" first="Yu-Tang" last="Gao">Yu-Tang Gao</name><affiliation><nlm:aff id="af127"><addr-line>Department of Epidemiology</addr-line>,<institution>Shanghai Cancer Institute</institution>,<addr-line>Shanghai 220025</addr-line>,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Cai, Hui" sort="Cai, Hui" uniqKey="Cai H" first="Hui" last="Cai">Hui Cai</name><affiliation><nlm:aff id="af106"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center</addr-line>,<institution>Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN 37232</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name><affiliation><nlm:aff id="af128"><addr-line>Department of Neuroscience</addr-line>,<institution>University of Sheffield</institution>,<addr-line>Royal Hallamshire Hospital, Sheffield S10 2JF</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Reed, Malcolm W R" sort="Reed, Malcolm W R" uniqKey="Reed M" first="Malcolm W. R." last="Reed">Malcolm W. R. Reed</name><affiliation><nlm:aff id="af1"><addr-line>Department of Oncology</addr-line>,<institution>University of Sheffield Medical School</institution>,<addr-line>Sheffield S10 2RX</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Blot, William" sort="Blot, William" uniqKey="Blot W" first="William" last="Blot">William Blot</name><affiliation><nlm:aff id="af106"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center</addr-line>,<institution>Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN 37232</addr-line>,<country>USA</country></nlm:aff></affiliation><affiliation><nlm:aff id="af129"><institution>International Epidemiology Institute</institution>,<addr-line>Rockville, MD 20850</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Signorello, Lisa B" sort="Signorello, Lisa B" uniqKey="Signorello L" first="Lisa B." last="Signorello">Lisa B. Signorello</name><affiliation><nlm:aff id="af106"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center</addr-line>,<institution>Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN 37232</addr-line>,<country>USA</country></nlm:aff></affiliation><affiliation><nlm:aff id="af129"><institution>International Epidemiology Institute</institution>,<addr-line>Rockville, MD 20850</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Cai, Qiuyin" sort="Cai, Qiuyin" uniqKey="Cai Q" first="Qiuyin" last="Cai">Qiuyin Cai</name><affiliation><nlm:aff id="af106"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center</addr-line>,<institution>Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN 37232</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB1 8RN</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Perkins, Barbara" sort="Perkins, Barbara" uniqKey="Perkins B" first="Barbara" last="Perkins">Barbara Perkins</name><affiliation><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB1 8RN</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name><affiliation><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB1 8RN</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Blows, Fiona M" sort="Blows, Fiona M" uniqKey="Blows F" first="Fiona M." last="Blows">Fiona M. Blows</name><affiliation><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB1 8RN</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Kang, Daehee" sort="Kang, Daehee" uniqKey="Kang D" first="Daehee" last="Kang">Daehee Kang</name><affiliation><nlm:aff id="af130"><addr-line>Department of Preventive Medicine</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af133"><addr-line>Department of Biomedical Sciences</addr-line>,<institution>Seoul National University Graduate School</institution>,<addr-line>Seoul 151-742</addr-line>,<country>Korea</country></nlm:aff></affiliation></author><author><name sortKey="Yoo, Keun Young" sort="Yoo, Keun Young" uniqKey="Yoo K" first="Keun-Young" last="Yoo">Keun-Young Yoo</name><affiliation><nlm:aff id="af132"><institution>Seoul National University College of Medicine</institution>,<addr-line>Seoul 110-799</addr-line>,<country>Korea</country></nlm:aff></affiliation></author><author><name sortKey="Noh, Dong Young" sort="Noh, Dong Young" uniqKey="Noh D" first="Dong-Young" last="Noh">Dong-Young Noh</name><affiliation><nlm:aff id="af131"><addr-line>Department of Surgery</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hartman, Mikael" sort="Hartman, Mikael" uniqKey="Hartman M" first="Mikael" last="Hartman">Mikael Hartman</name><affiliation><nlm:aff id="af134"><addr-line>Saw Swee Hock School of Public Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af135"><addr-line>Department of Surgery, Yong Loo Lin School of Medicine</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af137"><institution>National University Health System</institution>,<addr-line>Singapore 119228</addr-line>,<country>Singapore</country></nlm:aff></affiliation></author><author><name sortKey="Miao, Hui" sort="Miao, Hui" uniqKey="Miao H" first="Hui" last="Miao">Hui Miao</name><affiliation><nlm:aff id="af134"><addr-line>Saw Swee Hock School of Public Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af137"><institution>National University Health System</institution>,<addr-line>Singapore 119228</addr-line>,<country>Singapore</country></nlm:aff></affiliation></author><author><name sortKey="Chia, Kee Seng" sort="Chia, Kee Seng" uniqKey="Chia K" first="Kee Seng" last="Chia">Kee Seng Chia</name><affiliation><nlm:aff id="af134"><addr-line>Saw Swee Hock School of Public Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af137"><institution>National University Health System</institution>,<addr-line>Singapore 119228</addr-line>,<country>Singapore</country></nlm:aff></affiliation></author><author><name sortKey="Putti, Thomas Choudary" sort="Putti, Thomas Choudary" uniqKey="Putti T" first="Thomas Choudary" last="Putti">Thomas Choudary Putti</name><affiliation><nlm:aff id="af136"><addr-line>Department of Pathology, Yong Loo Lin School of Medicine</addr-line>,<institution>National University of Singapore</institution>,<addr-line>Singapore 117597</addr-line>,<country>Singapore</country></nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="af33"><addr-line>Molecular Genetics of Breast Cancer</addr-line></nlm:aff></affiliation></author><author><name sortKey="Luccarini, Craig" sort="Luccarini, Craig" uniqKey="Luccarini C" first="Craig" last="Luccarini">Craig Luccarini</name><affiliation><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB1 8RN</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Baynes, Caroline" sort="Baynes, Caroline" uniqKey="Baynes C" first="Caroline" last="Baynes">Caroline Baynes</name><affiliation><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB1 8RN</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Ahmed, Shahana" sort="Ahmed, Shahana" uniqKey="Ahmed S" first="Shahana" last="Ahmed">Shahana Ahmed</name><affiliation><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB1 8RN</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Maranian, Mel" sort="Maranian, Mel" uniqKey="Maranian M" first="Mel" last="Maranian">Mel Maranian</name><affiliation><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB1 8RN</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Healey, Catherine S" sort="Healey, Catherine S" uniqKey="Healey C" first="Catherine S." last="Healey">Catherine S. Healey</name><affiliation><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB1 8RN</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="af138"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin 70-204</addr-line>,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="af138"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin 70-204</addr-line>,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Jaworska Bieniek, Katarzyna" sort="Jaworska Bieniek, Katarzyna" uniqKey="Jaworska Bieniek K" first="Katarzyna" last="Jaworska-Bieniek">Katarzyna Jaworska-Bieniek</name><affiliation><nlm:aff id="af138"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin 70-204</addr-line>,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><affiliation><nlm:aff id="af138"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin 70-204</addr-line>,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Sangrajrang, Suleeporn" sort="Sangrajrang, Suleeporn" uniqKey="Sangrajrang S" first="Suleeporn" last="Sangrajrang">Suleeporn Sangrajrang</name><affiliation><nlm:aff id="af139"><institution>National Cancer Institute</institution>,<addr-line>Bangkok 10400</addr-line>,<country>Thailand</country></nlm:aff></affiliation></author><author><name sortKey="Gaborieau, Valerie" sort="Gaborieau, Valerie" uniqKey="Gaborieau V" first="Valerie" last="Gaborieau">Valerie Gaborieau</name><affiliation><nlm:aff id="af140"><institution>International Agency for Research on Cancer</institution>,<addr-line>Lyon 69372</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation><nlm:aff id="af140"><institution>International Agency for Research on Cancer</institution>,<addr-line>Lyon 69372</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Mckay, James" sort="Mckay, James" uniqKey="Mckay J" first="James" last="Mckay">James Mckay</name><affiliation><nlm:aff id="af140"><institution>International Agency for Research on Cancer</institution>,<addr-line>Lyon 69372</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Slager, Susan" sort="Slager, Susan" uniqKey="Slager S" first="Susan" last="Slager">Susan Slager</name><affiliation><nlm:aff id="af92"><addr-line>Department of Health Sciences Research</addr-line>,<institution>Mayo Clinic</institution>,<addr-line>Rochester, MN 55905</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name><affiliation><nlm:aff id="af141"><addr-line>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center</addr-line>,<institution>The Ohio State University</institution>,<addr-line>Columbus, OH 43210</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name><affiliation><nlm:aff id="af142"><addr-line>Molecular Diagnostics Laboratory</addr-line>,<institution>IRRP, National Centre for Scientific Research ‘Demokritos’</institution>,<addr-line>Aghia Paraskevi Attikis, Athens 153 10</addr-line>,<country>Greece</country></nlm:aff></affiliation></author><author><name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name><affiliation><nlm:aff id="af143"><addr-line>Institute of Biomedical Sciences</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af145"><institution>College of Public Health</institution>,<institution>China Medical University</institution>,<addr-line>Taichung 40402</addr-line>,<country>Taiwan</country></nlm:aff></affiliation></author><author><name sortKey="Hsiung, Chia Ni" sort="Hsiung, Chia Ni" uniqKey="Hsiung C" first="Chia-Ni" last="Hsiung">Chia-Ni Hsiung</name><affiliation><nlm:aff id="af143"><addr-line>Institute of Biomedical Sciences</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wu, Pei Ei" sort="Wu, Pei Ei" uniqKey="Wu P" first="Pei-Ei" last="Wu">Pei-Ei Wu</name><affiliation><nlm:aff id="af144"><addr-line>Taiwan Biobank, Institute of Biomedical Sciences</addr-line>,<institution>Academia Sinica</institution>,<addr-line>Taipei 115</addr-line>,<country>Taiwan</country></nlm:aff></affiliation></author><author><name sortKey="Ding, Shian Ling" sort="Ding, Shian Ling" uniqKey="Ding S" first="Shian-Ling" last="Ding">Shian-Ling Ding</name><affiliation><nlm:aff id="af146"><addr-line>Department of Nursing</addr-line>,<institution>Kang-Ning Junior College of Medical Care and Management</institution>,<addr-line>Taipei 11529</addr-line>,<country>Taiwan</country></nlm:aff></affiliation></author><author><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name><affiliation><nlm:aff id="af22"><addr-line>Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research</addr-line></nlm:aff></affiliation></author><author><name sortKey="Jones, Michael" sort="Jones, Michael" uniqKey="Jones M" first="Michael" last="Jones">Michael Jones</name><affiliation><nlm:aff id="af119"><addr-line>Division of Genetics and Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><affiliation><nlm:aff id="af23"><addr-line>Breakthrough Breast Cancer Research Centre and Division of Breast Cancer Research</addr-line>,<institution>The Institute of Cancer Research</institution>,<addr-line>London SW3 6JB</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony J" sort="Swerdlow, Anthony J" uniqKey="Swerdlow A" first="Anthony J" last="Swerdlow">Anthony J. Swerdlow</name><affiliation><nlm:aff id="af119"><addr-line>Division of Genetics and Epidemiology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af120"><addr-line>Division of Breast Cancer Research</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tsimiklis, Helen" sort="Tsimiklis, Helen" uniqKey="Tsimiklis H" first="Helen" last="Tsimiklis">Helen Tsimiklis</name><affiliation><nlm:aff id="af11"><addr-line>Genetic Epidemiology Laboratory, Department of Pathology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name><affiliation><nlm:aff id="af12"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>Melbourne, VIC 3010</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Schmidt, Daniel F" sort="Schmidt, Daniel F" uniqKey="Schmidt D" first="Daniel F." last="Schmidt">Daniel F. Schmidt</name><affiliation><nlm:aff id="af12"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>Melbourne, VIC 3010</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Bui, Quang M" sort="Bui, Quang M" uniqKey="Bui Q" first="Quang M." last="Bui">Quang M. Bui</name><affiliation><nlm:aff id="af12"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>Melbourne, VIC 3010</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="af122"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD 20850</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation><nlm:aff id="af147"><addr-line>Program in Molecular and Genetic Epidemiology</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston, MA 02115</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Hein, Rebecca" sort="Hein, Rebecca" uniqKey="Hein R" first="Rebecca" last="Hein">Rebecca Hein</name><affiliation><nlm:aff id="af34"><addr-line>Division of Cancer Epidemiology</addr-line>,<institution>German Cancer Research Center (DKFZ)</institution>,<addr-line>Heidelberg 69120</addr-line>,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="af148"><addr-line>PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy</addr-line>,<institution>University of Cologne</institution>,<addr-line>Cologne 50923</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Dahmen, Norbert" sort="Dahmen, Norbert" uniqKey="Dahmen N" first="Norbert" last="Dahmen">Norbert Dahmen</name><affiliation><nlm:aff id="af149"><addr-line>Department of Psychiatry</addr-line>,<institution>University of Mainz</institution>,<addr-line>Mainz 55122</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Beckmann, Lars" sort="Beckmann, Lars" uniqKey="Beckmann L" first="Lars" last="Beckmann">Lars Beckmann</name><affiliation><nlm:aff id="af150"><institution>Institute for Quality and Efficiency in Health Care (IQWiG)</institution>,<addr-line>Cologne 50670</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Aaltonen, Kirsimari" sort="Aaltonen, Kirsimari" uniqKey="Aaltonen K" first="Kirsimari" last="Aaltonen">Kirsimari Aaltonen</name><affiliation><nlm:aff id="af62"><addr-line>Department of Obstetrics and Gynecology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af65"><institution>Helsinki University Central Hospital</institution>,<addr-line>Helsinki 00029</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A." last="Muranen">Taru A. Muranen</name><affiliation><nlm:aff id="af62"><addr-line>Department of Obstetrics and Gynecology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af65"><institution>Helsinki University Central Hospital</institution>,<addr-line>Helsinki 00029</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Heikkinen, Tuomas" sort="Heikkinen, Tuomas" uniqKey="Heikkinen T" first="Tuomas" last="Heikkinen">Tuomas Heikkinen</name><affiliation><nlm:aff id="af62"><addr-line>Department of Obstetrics and Gynecology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af65"><institution>Helsinki University Central Hospital</institution>,<addr-line>Helsinki 00029</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Irwanto, Astrid" sort="Irwanto, Astrid" uniqKey="Irwanto A" first="Astrid" last="Irwanto">Astrid Irwanto</name><affiliation><nlm:aff id="af125"><addr-line>Human Genetics Division</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore 138672</addr-line>,<country>Singapore</country></nlm:aff></affiliation></author><author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><affiliation><nlm:aff id="af119"><addr-line>Division of Genetics and Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Turnbull, Clare A" sort="Turnbull, Clare A" uniqKey="Turnbull C" first="Clare A." last="Turnbull">Clare A. Turnbull</name><affiliation><nlm:aff id="af119"><addr-line>Division of Genetics and Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Waisfisz, Quinten" sort="Waisfisz, Quinten" uniqKey="Waisfisz Q" first="Quinten" last="Waisfisz">Quinten Waisfisz</name><affiliation><nlm:aff wicri:cut=" and" id="af151"><addr-line>Department of Clinical Genetics, Section Oncogenetics</addr-line>,<institution>VU University Medical Center</institution>,<addr-line>Amsterdam 1081 HZ</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Meijers Heijboer, Hanne E J" sort="Meijers Heijboer, Hanne E J" uniqKey="Meijers Heijboer H" first="Hanne E. J." last="Meijers-Heijboer">Hanne E. J. Meijers-Heijboer</name><affiliation><nlm:aff wicri:cut=" and" id="af151"><addr-line>Department of Clinical Genetics, Section Oncogenetics</addr-line>,<institution>VU University Medical Center</institution>,<addr-line>Amsterdam 1081 HZ</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Adank, Muriel A" sort="Adank, Muriel A" uniqKey="Adank M" first="Muriel A." last="Adank">Muriel A. Adank</name><affiliation><nlm:aff wicri:cut=" and" id="af151"><addr-line>Department of Clinical Genetics, Section Oncogenetics</addr-line>,<institution>VU University Medical Center</institution>,<addr-line>Amsterdam 1081 HZ</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Van Der Luijt, Rob B" sort="Van Der Luijt, Rob B" uniqKey="Van Der Luijt R" first="Rob B." last="Van Der Luijt">Rob B. Van Der Luijt</name><affiliation><nlm:aff id="af152"><addr-line>Department of Medical Genetics</addr-line>,<institution>University Medical Center Utrecht</institution>,<addr-line>Utrecht 3584 CX</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="af74"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm 17177</addr-line>,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="af6"><addr-line>Department of Genetics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison" sort="Dunning, Alison" uniqKey="Dunning A" first="Alison" last="Dunning">Alison Dunning</name><affiliation><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB1 8RN</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB1 8RN</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="af1"><addr-line>Department of Oncology</addr-line>,<institution>University of Sheffield Medical School</institution>,<addr-line>Sheffield S10 2RX</addr-line>,<country>UK</country></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25168388</idno><idno type="pmc">4334820</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334820</idno><idno type="RBID">PMC:4334820</idno><idno type="doi">10.1093/hmg/ddu431</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001875</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001875</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Identification and characterization of novel associations in the <italic>CASP8/ALS2CR12</italic> region on chromosome 2 with breast cancer risk</title><author><name sortKey="Lin, Wei Yu" sort="Lin, Wei Yu" uniqKey="Lin W" first="Wei-Yu" last="Lin">Wei-Yu Lin</name><affiliation><nlm:aff id="af1"><addr-line>Department of Oncology</addr-line>,<institution>University of Sheffield Medical School</institution>,<addr-line>Sheffield S10 2RX</addr-line>,<country>UK</country></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Neurosurgery</addr-line>,<institution>Chang Gung Memorial Hospital</institution>,<addr-line>Taoyuan County 333</addr-line>,<country>Taiwan</country></nlm:aff></affiliation></author><author><name sortKey="Camp, Nicola J" sort="Camp, Nicola J" uniqKey="Camp N" first="Nicola J." last="Camp">Nicola J. Camp</name><affiliation><nlm:aff id="af3"><addr-line>Department of Internal Medicine</addr-line>,<institution>University of Utah School of Medicine</institution>,<addr-line>Salt Lake City, UT 84108-1266</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Ghoussaini, Maya" sort="Ghoussaini, Maya" uniqKey="Ghoussaini M" first="Maya" last="Ghoussaini">Maya Ghoussaini</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line></nlm:aff></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation><nlm:aff id="af6"><addr-line>Department of Genetics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="af8"><addr-line>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation><nlm:aff id="af8"><addr-line>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="af9"><addr-line>Department of Pathology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stone, Jennifer" sort="Stone, Jennifer" uniqKey="Stone J" first="Jennifer" last="Stone">Jennifer Stone</name><affiliation><nlm:aff id="af10"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="af13"><addr-line>Netherlands Cancer Institute</addr-line>,<institution>Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam 1066 CX</addr-line>,<country>the Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation><nlm:aff id="af13"><addr-line>Netherlands Cancer Institute</addr-line>,<institution>Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam 1066 CX</addr-line>,<country>the Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Van T Veer, Laura J" sort="Van T Veer, Laura J" uniqKey="Van T Veer L" first="Laura J." last="Van'T Veer">Laura J. Van'T Veer</name><affiliation><nlm:aff id="af13"><addr-line>Netherlands Cancer Institute</addr-line>,<institution>Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam 1066 CX</addr-line>,<country>the Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Th Rutgers, Emiel J" sort="Th Rutgers, Emiel J" uniqKey="Th Rutgers E" first="Emiel J." last="Th Rutgers">Emiel J. Th Rutgers</name><affiliation><nlm:aff id="af13"><addr-line>Netherlands Cancer Institute</addr-line>,<institution>Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam 1066 CX</addr-line>,<country>the Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation><nlm:aff id="af14"><addr-line>Division of Health Sciences, Warwick Medical School</addr-line>,<institution>Warwick University</institution>,<addr-line>Coventry CV4 7AL</addr-line>,<country>UK</country></nlm:aff></affiliation><affiliation><nlm:aff id="af15"><addr-line>Institute of Population Health</addr-line>,<institution>University of Manchester</institution>,<addr-line>Manchester M13 9QQ</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name><affiliation><nlm:aff id="af14"><addr-line>Division of Health Sciences, Warwick Medical School</addr-line>,<institution>Warwick University</institution>,<addr-line>Coventry CV4 7AL</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Stewart Brown, Sarah" sort="Stewart Brown, Sarah" uniqKey="Stewart Brown S" first="Sarah" last="Stewart-Brown">Sarah Stewart-Brown</name><affiliation><nlm:aff id="af14"><addr-line>Division of Health Sciences, Warwick Medical School</addr-line>,<institution>Warwick University</institution>,<addr-line>Coventry CV4 7AL</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Siriwanarangsan, Pornthep" sort="Siriwanarangsan, Pornthep" uniqKey="Siriwanarangsan P" first="Pornthep" last="Siriwanarangsan">Pornthep Siriwanarangsan</name><affiliation><nlm:aff id="af16"><addr-line>Ministry of Public Health, Nonthaburi 11000</addr-line>,<country>Thailand</country></nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="af17"><addr-line>University Breast Center Franconia, Department of Gynecology and Obstetrics</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af19"><addr-line>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology</addr-line>,<institution>University of California</institution>,<addr-line>Los Angeles, CA 90095</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Haeberle, Lothar" sort="Haeberle, Lothar" uniqKey="Haeberle L" first="Lothar" last="Haeberle">Lothar Haeberle</name><affiliation><nlm:aff id="af17"><addr-line>University Breast Center Franconia, Department of Gynecology and Obstetrics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation><nlm:aff id="af18"><addr-line>Institute of Human Genetics</addr-line>,<institution>University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg</institution>,<addr-line>Erlangen D-91054</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="af17"><addr-line>University Breast Center Franconia, Department of Gynecology and Obstetrics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="af20"><addr-line>Non-communicable Disease Epidemiology Department</addr-line>,<institution>London School of Hygiene and Tropical Medicine</institution>,<addr-line>London WC1E 7HT</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><affiliation><nlm:aff id="af20"><addr-line>Non-communicable Disease Epidemiology Department</addr-line>,<institution>London School of Hygiene and Tropical Medicine</institution>,<addr-line>London WC1E 7HT</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="af21"><addr-line>Breakthrough Breast Cancer Research Centre</addr-line></nlm:aff></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation><nlm:aff id="af21"><addr-line>Breakthrough Breast Cancer Research Centre</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name><affiliation><nlm:aff id="af24"><addr-line>Division of Cancer Studies</addr-line>,<institution>Kings College London</institution>,<institution>Guy's Hospital</institution>,<addr-line>London SE1 9RT</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Cheng, Timothy" sort="Cheng, Timothy" uniqKey="Cheng T" first="Timothy" last="Cheng">Timothy Cheng</name><affiliation><nlm:aff id="af25"><addr-line>Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford OX3 7BN</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation><nlm:aff id="af25"><addr-line>Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford OX3 7BN</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Kerin, Michael J" sort="Kerin, Michael J" uniqKey="Kerin M" first="Michael J." last="Kerin">Michael J. Kerin</name><affiliation><nlm:aff id="af26"><addr-line>School of Medicine, National University of Ireland</addr-line>,<country>Galway, Ireland</country></nlm:aff></affiliation></author><author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name><affiliation><nlm:aff id="af26"><addr-line>School of Medicine, National University of Ireland</addr-line>,<country>Galway, Ireland</country></nlm:aff></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marmé">Frederik Marmé</name><affiliation><nlm:aff id="af27"><addr-line>Department of Obstetrics and Gynecology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af28"><addr-line>National Center for Tumor Diseases</addr-line>,<institution>University of Heidelberg</institution>,<addr-line>Heidelberg 69117</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Surowy, Harald M" sort="Surowy, Harald M" uniqKey="Surowy H" first="Harald M." last="Surowy">Harald M. Surowy</name><affiliation><nlm:aff id="af27"><addr-line>Department of Obstetrics and Gynecology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af29"><addr-line>Molecular Epidemiology Group</addr-line></nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="af27"><addr-line>Department of Obstetrics and Gynecology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af29"><addr-line>Molecular Epidemiology Group</addr-line></nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation><nlm:aff id="af35"><addr-line>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health)</addr-line>,<institution>U1018, Environmental Epidemiology of Cancer</institution>,<addr-line>Villejuif 94807</addr-line>,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af36"><institution>University Paris-Sud, UMRS 1018</institution>,<addr-line>Villejuif 94807</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation><nlm:aff id="af35"><addr-line>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health)</addr-line>,<institution>U1018, Environmental Epidemiology of Cancer</institution>,<addr-line>Villejuif 94807</addr-line>,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af36"><institution>University Paris-Sud, UMRS 1018</institution>,<addr-line>Villejuif 94807</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Menegaux, Florence" sort="Menegaux, Florence" uniqKey="Menegaux F" first="Florence" last="Menegaux">Florence Menegaux</name><affiliation><nlm:aff id="af35"><addr-line>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health)</addr-line>,<institution>U1018, Environmental Epidemiology of Cancer</institution>,<addr-line>Villejuif 94807</addr-line>,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af36"><institution>University Paris-Sud, UMRS 1018</institution>,<addr-line>Villejuif 94807</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Mulot, Claire" sort="Mulot, Claire" uniqKey="Mulot C" first="Claire" last="Mulot">Claire Mulot</name><affiliation><nlm:aff id="af37"><institution>Université Paris Sorbonne Cité, UMR-S775 Inserm</institution>,<addr-line>Paris 75015</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="af38"><addr-line>Copenhagen General Population Study</addr-line>,<institution>Herlev Hospital</institution>,<addr-line>2730 Herlev, Copenhagen</addr-line>,<country>Denmark</country></nlm:aff></affiliation><affiliation><nlm:aff id="af39"><addr-line>Department of Clinical Biochemistry</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af41"><addr-line>Faculty of Health and Medical Sciences</addr-line>,<institution>University of Copenhagen</institution>,<addr-line>Copenhagen 2200</addr-line>,<country>Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation><nlm:aff id="af38"><addr-line>Copenhagen General Population Study</addr-line>,<institution>Herlev Hospital</institution>,<addr-line>2730 Herlev, Copenhagen</addr-line>,<country>Denmark</country></nlm:aff></affiliation><affiliation><nlm:aff id="af39"><addr-line>Department of Clinical Biochemistry</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af41"><addr-line>Faculty of Health and Medical Sciences</addr-line>,<institution>University of Copenhagen</institution>,<addr-line>Copenhagen 2200</addr-line>,<country>Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Nielsen, Sune F" sort="Nielsen, Sune F" uniqKey="Nielsen S" first="Sune F." last="Nielsen">Sune F. Nielsen</name><affiliation><nlm:aff id="af38"><addr-line>Copenhagen General Population Study</addr-line>,<institution>Herlev Hospital</institution>,<addr-line>2730 Herlev, Copenhagen</addr-line>,<country>Denmark</country></nlm:aff></affiliation><affiliation><nlm:aff id="af39"><addr-line>Department of Clinical Biochemistry</addr-line></nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="af40"><addr-line>Department of Breast Surgery</addr-line>,<institution>Herlev Hospital, Copenhagen University Hospital</institution>,<addr-line>Copenhagen 2100</addr-line>,<country>Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="af42"><addr-line>Human Genetics Group, Human Cancer Genetics Program</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af44"><institution>Centro de Investigación en Red de Enfermedades Raras (CIBERER)</institution>,<addr-line>Valencia 28029</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Zamora, M Pilar" sort="Zamora, M Pilar" uniqKey="Zamora M" first="M. Pilar" last="Zamora">M. Pilar Zamora</name><affiliation><nlm:aff id="af45"><addr-line>Servicio de Oncología Médica</addr-line>,<institution>Hospital Universitario La Paz</institution>,<addr-line>Madrid 28046</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Arias Perez, Jose Ignacio" sort="Arias Perez, Jose Ignacio" uniqKey="Arias Perez J" first="Jose Ignacio" last="Arias Perez">Jose Ignacio Arias Perez</name><affiliation><nlm:aff id="af46"><addr-line>Servicio de Cirugía General y Especialidades</addr-line></nlm:aff></affiliation></author><author><name sortKey="Menendez, Primitiva" sort="Menendez, Primitiva" uniqKey="Menendez P" first="Primitiva" last="Menéndez">Primitiva Menéndez</name><affiliation><nlm:aff id="af47"><addr-line>Servicio de Anatomía Patológica</addr-line>,<institution>Hospital Monte Naranco</institution>,<addr-line>Oviedo 33012</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name><affiliation><nlm:aff id="af43"><addr-line>Human Genotyping-CEGEN Unit, Human Cancer Genetics Program</addr-line>,<institution>Spanish National Cancer Research Centre (CNIO)</institution>,<addr-line>Madrid E-28029</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Pita, Guillermo" sort="Pita, Guillermo" uniqKey="Pita G" first="Guillermo" last="Pita">Guillermo Pita</name><affiliation><nlm:aff id="af43"><addr-line>Human Genotyping-CEGEN Unit, Human Cancer Genetics Program</addr-line>,<institution>Spanish National Cancer Research Centre (CNIO)</institution>,<addr-line>Madrid E-28029</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Alonso, M Rosario" sort="Alonso, M Rosario" uniqKey="Alonso M" first="M. Rosario" last="Alonso">M. Rosario Alonso</name><affiliation><nlm:aff id="af43"><addr-line>Human Genotyping-CEGEN Unit, Human Cancer Genetics Program</addr-line>,<institution>Spanish National Cancer Research Centre (CNIO)</institution>,<addr-line>Madrid E-28029</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Alvarez, Nuria" sort="Alvarez, Nuria" uniqKey="Alvarez N" first="Nuria" last="Álvarez">Nuria Álvarez</name><affiliation><nlm:aff id="af43"><addr-line>Human Genotyping-CEGEN Unit, Human Cancer Genetics Program</addr-line>,<institution>Spanish National Cancer Research Centre (CNIO)</institution>,<addr-line>Madrid E-28029</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Herrero, Daniel" sort="Herrero, Daniel" uniqKey="Herrero D" first="Daniel" last="Herrero">Daniel Herrero</name><affiliation><nlm:aff id="af43"><addr-line>Human Genotyping-CEGEN Unit, Human Cancer Genetics Program</addr-line>,<institution>Spanish National Cancer Research Centre (CNIO)</institution>,<addr-line>Madrid E-28029</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="af48"><addr-line>Department of Epidemiology</addr-line>,<institution>University of California Irvine</institution>,<addr-line>Irvine, CA 92697</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="af30"><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af49"><institution>German Cancer Consortium (DKTK)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Dieffenbach, Aida Karina" sort="Dieffenbach, Aida Karina" uniqKey="Dieffenbach A" first="Aida Karina" last="Dieffenbach">Aida Karina Dieffenbach</name><affiliation><nlm:aff id="af30"><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af49"><institution>German Cancer Consortium (DKTK)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="af30"><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name><affiliation><nlm:aff id="af50"><institution>Saarland Cancer Registry</institution>,<addr-line>Saarbrücken 66024</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="af51"><addr-line>Division of Gynaecology and Obstetrics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lichtner, Peter" sort="Lichtner, Peter" uniqKey="Lichtner P" first="Peter" last="Lichtner">Peter Lichtner</name><affiliation><nlm:aff id="af52"><addr-line>Insitute of Human Genetics</addr-line>,<institution>Technische Universität München</institution>,<addr-line>Munich D-80333</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="af53"><addr-line>Center for Hereditary Breast and Ovarian Cancer</addr-line>,<institution>Center for Integrated Oncology (CIO) and Center for Molecular Medicine Cologne (CMMC)</institution>,<addr-line>Medical Faculty, University of Cologne and University Hospital Cologne, 50932 Cologne</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name><affiliation><nlm:aff id="af54"><institution>Max Planck Institute of Psychiatry</institution>,<addr-line>Munich 80804</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="af55"><institution>Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology</institution>,<addr-line>Stuttgart 70376</addr-line>,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="af56"><institution>University of Tübingen</institution>,<addr-line>Tübingen 72074</addr-line>,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="af31"><addr-line>German Cancer Consortium (DKTK)</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><affiliation><nlm:aff id="af57"><addr-line>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance</addr-line>,<institution>Institute of the Ruhr-University Bochum (IPA)</institution>,<addr-line>Bochum D-44789</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name><affiliation><nlm:aff id="af58"><addr-line>Department of Internal Medicine</addr-line>,<institution>Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus</institution>,<addr-line>Bonn 53113</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Tessier, Daniel C" sort="Tessier, Daniel C" uniqKey="Tessier D" first="Daniel C." last="Tessier">Daniel C. Tessier</name><affiliation><nlm:aff id="af61"><institution>Centre D'innovation Génome Québec et Université McGill</institution>,<addr-line>Montréal, QC</addr-line>,<country>Canada</country><addr-line>H3A 0G1</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vincent, Daniel" sort="Vincent, Daniel" uniqKey="Vincent D" first="Daniel" last="Vincent">Daniel Vincent</name><affiliation><nlm:aff id="af61"><institution>Centre D'innovation Génome Québec et Université McGill</institution>,<addr-line>Montréal, QC</addr-line>,<country>Canada</country><addr-line>H3A 0G1</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bacot, Francois" sort="Bacot, Francois" uniqKey="Bacot F" first="Francois" last="Bacot">Francois Bacot</name><affiliation><nlm:aff id="af61"><institution>Centre D'innovation Génome Québec et Université McGill</institution>,<addr-line>Montréal, QC</addr-line>,<country>Canada</country><addr-line>H3A 0G1</addr-line></nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="af62"><addr-line>Department of Obstetrics and Gynecology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af65"><institution>Helsinki University Central Hospital</institution>,<addr-line>Helsinki 00029</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="af63"><addr-line>Department of Clinical Genetics</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af65"><institution>Helsinki University Central Hospital</institution>,<addr-line>Helsinki 00029</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation><nlm:aff id="af64"><addr-line>Department of Oncology, University of Helsinki</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af65"><institution>Helsinki University Central Hospital</institution>,<addr-line>Helsinki 00029</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Khan, Sofia" sort="Khan, Sofia" uniqKey="Khan S" first="Sofia" last="Khan">Sofia Khan</name><affiliation><nlm:aff id="af62"><addr-line>Department of Obstetrics and Gynecology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af65"><institution>Helsinki University Central Hospital</institution>,<addr-line>Helsinki 00029</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Matsuo, Keitaro" sort="Matsuo, Keitaro" uniqKey="Matsuo K" first="Keitaro" last="Matsuo">Keitaro Matsuo</name><affiliation><nlm:aff id="af66"><addr-line>Department of Preventive Medicine</addr-line>,<institution>Kyushu University Faculty of Medical Sciences</institution>,<addr-line>Fukuoka 812-8582</addr-line>,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Ito, Hidemi" sort="Ito, Hidemi" uniqKey="Ito H" first="Hidemi" last="Ito">Hidemi Ito</name><affiliation><nlm:aff id="af67"><addr-line>Division of Epidemiology and Prevention</addr-line>,<institution>Aichi Cancer Center Research Institute</institution>,<addr-line>Nagoya 464-8681</addr-line>,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Iwata, Hiroji" sort="Iwata, Hiroji" uniqKey="Iwata H" first="Hiroji" last="Iwata">Hiroji Iwata</name><affiliation><nlm:aff id="af68"><addr-line>Department of Breast Oncology</addr-line>,<institution>Aichi Cancer Center Hospital</institution>,<addr-line>Nagoya 464-8681</addr-line>,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Horio, Akiyo" sort="Horio, Akiyo" uniqKey="Horio A" first="Akiyo" last="Horio">Akiyo Horio</name><affiliation><nlm:aff id="af68"><addr-line>Department of Breast Oncology</addr-line>,<institution>Aichi Cancer Center Hospital</institution>,<addr-line>Nagoya 464-8681</addr-line>,<country>Japan</country></nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name><affiliation><nlm:aff id="af69"><addr-line>Department of Obstetrics and Gynaecology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af70"><addr-line>Department of Radiation Oncology</addr-line>,<institution>Hannover Medical School</institution>,<addr-line>Hannover 30625</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Antonenkova, Natalia N" sort="Antonenkova, Natalia N" uniqKey="Antonenkova N" first="Natalia N." last="Antonenkova">Natalia N. Antonenkova</name><affiliation><nlm:aff id="af71"><institution>N.N. Alexandrov Research Institute of Oncology and Medical Radiology</institution>,<addr-line>Minsk 223040</addr-line>,<country>Belarus</country></nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="af69"><addr-line>Department of Obstetrics and Gynaecology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff id="af72"><addr-line>Department of Molecular Medicine and Surgery</addr-line></nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation><nlm:aff id="af73"><addr-line>Department of Oncology–Pathology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff id="af75"><addr-line>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine</addr-line> and Cancer Center of Eastern Finland</nlm:aff></affiliation><affiliation><nlm:aff id="af77"><addr-line>Imaging Center, Department of Clinical Pathology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name><affiliation><nlm:aff id="af76"><addr-line>School of Medicine, Institute of Clinical Medicine, Oncology</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio 70210</addr-line>,<country>Finland</country></nlm:aff></affiliation><affiliation><nlm:aff id="af78"><addr-line>Cancer Center</addr-line>,<institution>Kuopio University Hospital</institution>,<addr-line>Kuopio 70029</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff id="af75"><addr-line>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine</addr-line> and Cancer Center of Eastern Finland</nlm:aff></affiliation><affiliation><nlm:aff id="af77"><addr-line>Imaging Center, Department of Clinical Pathology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M." last="Hartikainen">Jaana M. Hartikainen</name><affiliation><nlm:aff id="af75"><addr-line>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine</addr-line> and Cancer Center of Eastern Finland</nlm:aff></affiliation><affiliation><nlm:aff id="af77"><addr-line>Imaging Center, Department of Clinical Pathology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wu, Anna H" sort="Wu, Anna H" uniqKey="Wu A" first="Anna H." last="Wu">Anna H. Wu</name><affiliation><nlm:aff id="af80"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles, CA 90033</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Tseng, Chiu Chen" sort="Tseng, Chiu Chen" uniqKey="Tseng C" first="Chiu-Chen" last="Tseng">Chiu-Chen Tseng</name><affiliation><nlm:aff id="af80"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles, CA 90033</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Van Den Berg, David" sort="Van Den Berg, David" uniqKey="Van Den Berg D" first="David" last="Van Den Berg">David Van Den Berg</name><affiliation><nlm:aff id="af80"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles, CA 90033</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Stram, Daniel O" sort="Stram, Daniel O" uniqKey="Stram D" first="Daniel O." last="Stram">Daniel O. Stram</name><affiliation><nlm:aff id="af80"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles, CA 90033</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Neven, Patrick" sort="Neven, Patrick" uniqKey="Neven P" first="Patrick" last="Neven">Patrick Neven</name><affiliation><nlm:aff id="af81"><institution>University Hospital Gashuisberg</institution>,<addr-line>Leuven 3000</addr-line>,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Wauters, Els" sort="Wauters, Els" uniqKey="Wauters E" first="Els" last="Wauters">Els Wauters</name><affiliation><nlm:aff id="af82"><addr-line>Vesalius Research Center (VRC), VIB, Leuven 3000</addr-line>,<country>Belgium</country></nlm:aff></affiliation><affiliation><nlm:aff id="af83"><addr-line>Department of Oncology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wildiers, Hans" sort="Wildiers, Hans" uniqKey="Wildiers H" first="Hans" last="Wildiers">Hans Wildiers</name><affiliation><nlm:aff id="af85"><addr-line>Department of General Medical Oncology</addr-line>,<institution>University Hospitals Leuven</institution>,<addr-line>Leuven 3000</addr-line>,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="af82"><addr-line>Vesalius Research Center (VRC), VIB, Leuven 3000</addr-line>,<country>Belgium</country></nlm:aff></affiliation><affiliation><nlm:aff id="af84"><addr-line>Laboratory for Translational Genetics, Department of Oncology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="af32"><addr-line>Division of Cancer Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="af32"><addr-line>Division of Cancer Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Seibold, Petra" sort="Seibold, Petra" uniqKey="Seibold P" first="Petra" last="Seibold">Petra Seibold</name><affiliation><nlm:aff id="af32"><addr-line>Division of Cancer Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="af86"><addr-line>Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology</addr-line>,<institution>University Clinic Hamburg-Eppendorf</institution>,<addr-line>Hamburg D-20246</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="af87"><addr-line>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="af89"><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>,<addr-line>Milan 20139</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="af88"><addr-line>Unit of Medical Genetics, Department of Preventive and Predictive Medicine</addr-line>,<institution>Fondazione IRCCS Istituto Nazionale dei Tumori (INT)</institution>,<addr-line>Milan 20133</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name><affiliation><nlm:aff id="af90"><addr-line>Division of Cancer Prevention and Genetics</addr-line>,<institution>Istituto Europeo di Oncologia (IEO)</institution>,<addr-line>Milan 20141</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="af91"><addr-line>Department of Laboratory Medicine and Pathology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><nlm:aff id="af91"><addr-line>Department of Laboratory Medicine and Pathology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name><affiliation><nlm:aff id="af92"><addr-line>Department of Health Sciences Research</addr-line>,<institution>Mayo Clinic</institution>,<addr-line>Rochester, MN 55905</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Purrington, Kristen" sort="Purrington, Kristen" uniqKey="Purrington K" first="Kristen" last="Purrington">Kristen Purrington</name><affiliation><nlm:aff id="af93"><addr-line>Karmanos Cancer Center, Detroit, MI 48201</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="af8"><addr-line>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af94"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>Cancer Council Victoria</institution>,<addr-line>Melbourne, VIC 3004</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="af8"><addr-line>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af94"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>Cancer Council Victoria</institution>,<addr-line>Melbourne, VIC 3004</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name><affiliation><nlm:aff id="af95"><addr-line>Anatomical Pathology</addr-line>,<institution>The Alfred Hospital</institution>,<addr-line>Melbourne, VIC 3004</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="af80"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles, CA 90033</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation><nlm:aff id="af80"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles, CA 90033</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Schumacher, Fredrick" sort="Schumacher, Fredrick" uniqKey="Schumacher F" first="Fredrick" last="Schumacher">Fredrick Schumacher</name><affiliation><nlm:aff id="af80"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles, CA 90033</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="af96"><addr-line>Epidemiology Program</addr-line>,<institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI 96813</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="af97"><institution>Centre Hospitalier Universitaire de Québec Research Centre and Laval University</institution>,<addr-line>Quebec City, QC</addr-line>,<country>Canada</country><addr-line>G1V 4G2</addr-line></nlm:aff></affiliation></author><author><name sortKey="Goldberg, Mark S" sort="Goldberg, Mark S" uniqKey="Goldberg M" first="Mark S." last="Goldberg">Mark S. Goldberg</name><affiliation><nlm:aff id="af98"><addr-line>Department of Medicine</addr-line>,<institution>McGill University</institution>,<addr-line>Montreal, QC</addr-line>,<country>Canada</country><addr-line>H3A 0G4</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af99"><addr-line>Division of Clinical Epidemiology</addr-line>,<institution>McGill University Health Centre, Royal Victoria Hospital</institution>,<addr-line>Montreal, QC</addr-line>,<country>Canada</country><addr-line>H3A 1A1</addr-line></nlm:aff></affiliation></author><author><name sortKey="Labreche, France" sort="Labreche, France" uniqKey="Labreche F" first="France" last="Labrèche">France Labrèche</name><affiliation><nlm:aff id="af100"><addr-line>Départements de Santé Environnementale et Santé au Travail et de Médecine Sociale et Préventive, École de Santé Publique</addr-line>,<institution>Université de Montréal</institution>,<addr-line>Montreal, QC</addr-line>,<country>Canada</country><addr-line>H3T 1J4</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name><affiliation><nlm:aff id="af97"><institution>Centre Hospitalier Universitaire de Québec Research Centre and Laval University</institution>,<addr-line>Quebec City, QC</addr-line>,<country>Canada</country><addr-line>G1V 4G2</addr-line></nlm:aff></affiliation></author><author><name sortKey="Teo, Soo Hwang" sort="Teo, Soo Hwang" uniqKey="Teo S" first="Soo Hwang" last="Teo">Soo Hwang Teo</name><affiliation><nlm:aff id="af101"><addr-line>Cancer Research Initiatives Foundation</addr-line>,<institution>Sime Darby Medical Centre</institution>,<addr-line>Subang Jaya, Selangor</addr-line>,<country>Malaysia</country></nlm:aff></affiliation><affiliation><nlm:aff id="af102"><addr-line>Breast Cancer Research Unit</addr-line>,<institution>University Malaya Cancer Research Institute, University Malaya Medical Centre</institution>,<addr-line>Kuala Lumpur 50603</addr-line>,<country>Malaysia</country></nlm:aff></affiliation></author><author><name sortKey="Yip, Cheng Har" sort="Yip, Cheng Har" uniqKey="Yip C" first="Cheng Har" last="Yip">Cheng Har Yip</name><affiliation><nlm:aff id="af102"><addr-line>Breast Cancer Research Unit</addr-line>,<institution>University Malaya Cancer Research Institute, University Malaya Medical Centre</institution>,<addr-line>Kuala Lumpur 50603</addr-line>,<country>Malaysia</country></nlm:aff></affiliation></author><author><name sortKey="Hassan, Norhashimah" sort="Hassan, Norhashimah" uniqKey="Hassan N" first="Norhashimah" last="Hassan">Norhashimah Hassan</name><affiliation><nlm:aff id="af101"><addr-line>Cancer Research Initiatives Foundation</addr-line>,<institution>Sime Darby Medical Centre</institution>,<addr-line>Subang Jaya, Selangor</addr-line>,<country>Malaysia</country></nlm:aff></affiliation><affiliation><nlm:aff id="af102"><addr-line>Breast Cancer Research Unit</addr-line>,<institution>University Malaya Cancer Research Institute, University Malaya Medical Centre</institution>,<addr-line>Kuala Lumpur 50603</addr-line>,<country>Malaysia</country></nlm:aff></affiliation></author><author><name sortKey="Vithana, Eranga Nishanthie" sort="Vithana, Eranga Nishanthie" uniqKey="Vithana E" first="Eranga Nishanthie" last="Vithana">Eranga Nishanthie Vithana</name><affiliation><nlm:aff id="af103"><addr-line>Singapore Eye Research Institute</addr-line>,<institution>National University of Singapore</institution>,<addr-line>Singapore 119077</addr-line>,<country>Singapore</country></nlm:aff></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation><nlm:aff id="af104"><addr-line>Department of Genetics, Institute for Cancer Research</addr-line>,<institution>Oslo University Hospital, Radiumhospitalet</institution>,<addr-line>Oslo 0372</addr-line>,<country>Norway</country></nlm:aff></affiliation><affiliation><nlm:aff id="af105"><addr-line>Faculty of Medicine (Faculty Division Ahus)</addr-line>,<institution>University of Oslo (UiO)</institution>,<addr-line>Oslo 0316</addr-line>,<country>Norway</country></nlm:aff></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:aff id="af106"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center</addr-line>,<institution>Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN 37232</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Deming Halverson, Sandra" sort="Deming Halverson, Sandra" uniqKey="Deming Halverson S" first="Sandra" last="Deming-Halverson">Sandra Deming-Halverson</name><affiliation><nlm:aff id="af106"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center</addr-line>,<institution>Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN 37232</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Shrubsole, Martha J" sort="Shrubsole, Martha J" uniqKey="Shrubsole M" first="Martha J." last="Shrubsole">Martha J. Shrubsole</name><affiliation><nlm:aff id="af106"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center</addr-line>,<institution>Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN 37232</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Long, Jirong" sort="Long, Jirong" uniqKey="Long J" first="Jirong" last="Long">Jirong Long</name><affiliation><nlm:aff id="af106"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center</addr-line>,<institution>Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN 37232</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="af107"><addr-line>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, Northern Finland Laboratory Centre NordLab</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation><nlm:aff id="af107"><addr-line>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, Northern Finland Laboratory Centre NordLab</addr-line></nlm:aff></affiliation></author><author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name><affiliation><nlm:aff id="af108"><addr-line>Department of Oncology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kauppila, Saila" sort="Kauppila, Saila" uniqKey="Kauppila S" first="Saila" last="Kauppila">Saila Kauppila</name><affiliation><nlm:aff id="af109"><addr-line>Department of Pathology</addr-line>,<institution>Oulu University Hospital</institution>,<institution>University of Oulu</institution>,<addr-line>Oulu 90570</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="af110"><addr-line>Ontario Cancer Genetics Network</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af113"><addr-line>Department of Molecular Genetics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name><affiliation><nlm:aff id="af111"><addr-line>Prosserman Centre for Health Research</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af114"><addr-line>Division of Epidemiology, Dalla Lana School of Public Health</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto, ON</addr-line>,<country>Canada</country><addr-line>M5S 2J7</addr-line></nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="af110"><addr-line>Ontario Cancer Genetics Network</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tchatchou, Sandrine" sort="Tchatchou, Sandrine" uniqKey="Tchatchou S" first="Sandrine" last="Tchatchou">Sandrine Tchatchou</name><affiliation><nlm:aff id="af112"><institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto, ON</addr-line>,<country>Canada</country><addr-line>M5G 1X5</addr-line></nlm:aff></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:aff id="af115"><addr-line>Department of Human Genetics & Department of Pathology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tollenaar, Robert A E M" sort="Tollenaar, Robert A E M" uniqKey="Tollenaar R" first="Robert A. E. M." last="Tollenaar">Robert A. E. M. Tollenaar</name><affiliation><nlm:aff id="af116"><addr-line>Department of Surgical Oncology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name><affiliation><nlm:aff id="af118"><addr-line>Family Cancer Clinic, Department of Medical Oncology</addr-line>,<institution>Erasmus MC Cancer Institute</institution><addr-line>Rotterdam 3075 EA</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Van Asperen, Christi J" sort="Van Asperen, Christi J" uniqKey="Van Asperen C" first="Christi J." last="Van Asperen">Christi J. Van Asperen</name><affiliation><nlm:aff id="af117"><addr-line>Department of Clinical Genetics</addr-line>,<institution>Leiden University Medical Center</institution>,<addr-line>Leiden 2300 RC</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation><nlm:aff id="af22"><addr-line>Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af119"><addr-line>Division of Genetics and Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name><affiliation><nlm:aff id="af122"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD 20850</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><affiliation><nlm:aff id="af123"><addr-line>Department of Cancer Epidemiology and Prevention</addr-line>,<institution>M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology</institution>,<addr-line>Warsaw 02-781</addr-line>,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Brinton, Louise" sort="Brinton, Louise" uniqKey="Brinton L" first="Louise" last="Brinton">Louise Brinton</name><affiliation><nlm:aff id="af122"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD 20850</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="af74"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm 17177</addr-line>,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name><affiliation><nlm:aff id="af74"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm 17177</addr-line>,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Eriksson, Mikael" sort="Eriksson, Mikael" uniqKey="Eriksson M" first="Mikael" last="Eriksson">Mikael Eriksson</name><affiliation><nlm:aff id="af74"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm 17177</addr-line>,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Brand, Judith S" sort="Brand, Judith S" uniqKey="Brand J" first="Judith S." last="Brand">Judith S. Brand</name><affiliation><nlm:aff id="af74"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm 17177</addr-line>,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name><affiliation><nlm:aff id="af118"><addr-line>Family Cancer Clinic, Department of Medical Oncology</addr-line>,<institution>Erasmus MC Cancer Institute</institution><addr-line>Rotterdam 3075 EA</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation><nlm:aff id="af118"><addr-line>Family Cancer Clinic, Department of Medical Oncology</addr-line>,<institution>Erasmus MC Cancer Institute</institution><addr-line>Rotterdam 3075 EA</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Van Den Ouweland, Ans M W" sort="Van Den Ouweland, Ans M W" uniqKey="Van Den Ouweland A" first="Ans M. W." last="Van Den Ouweland">Ans M. W. Van Den Ouweland</name><affiliation><nlm:aff id="af124"><addr-line>Department of Clinical Genetics</addr-line>,<institution>Erasmus University Medical Center</institution>,<addr-line>Rotterdam 3075 EA</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Jager, Agnes" sort="Jager, Agnes" uniqKey="Jager A" first="Agnes" last="Jager">Agnes Jager</name><affiliation><nlm:aff id="af118"><addr-line>Family Cancer Clinic, Department of Medical Oncology</addr-line>,<institution>Erasmus MC Cancer Institute</institution><addr-line>Rotterdam 3075 EA</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation><nlm:aff id="af126"><addr-line>Shanghai Center for Disease Control and Prevention, Shanghai 200336</addr-line>,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation><nlm:aff id="af125"><addr-line>Human Genetics Division</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore 138672</addr-line>,<country>Singapore</country></nlm:aff></affiliation></author><author><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name><affiliation><nlm:aff id="af74"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm 17177</addr-line>,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation><nlm:aff id="af106"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center</addr-line>,<institution>Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN 37232</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Lu, Wei" sort="Lu, Wei" uniqKey="Lu W" first="Wei" last="Lu">Wei Lu</name><affiliation><nlm:aff id="af126"><addr-line>Shanghai Center for Disease Control and Prevention, Shanghai 200336</addr-line>,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Gao, Yu Tang" sort="Gao, Yu Tang" uniqKey="Gao Y" first="Yu-Tang" last="Gao">Yu-Tang Gao</name><affiliation><nlm:aff id="af127"><addr-line>Department of Epidemiology</addr-line>,<institution>Shanghai Cancer Institute</institution>,<addr-line>Shanghai 220025</addr-line>,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Cai, Hui" sort="Cai, Hui" uniqKey="Cai H" first="Hui" last="Cai">Hui Cai</name><affiliation><nlm:aff id="af106"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center</addr-line>,<institution>Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN 37232</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name><affiliation><nlm:aff id="af128"><addr-line>Department of Neuroscience</addr-line>,<institution>University of Sheffield</institution>,<addr-line>Royal Hallamshire Hospital, Sheffield S10 2JF</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Reed, Malcolm W R" sort="Reed, Malcolm W R" uniqKey="Reed M" first="Malcolm W. R." last="Reed">Malcolm W. R. Reed</name><affiliation><nlm:aff id="af1"><addr-line>Department of Oncology</addr-line>,<institution>University of Sheffield Medical School</institution>,<addr-line>Sheffield S10 2RX</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Blot, William" sort="Blot, William" uniqKey="Blot W" first="William" last="Blot">William Blot</name><affiliation><nlm:aff id="af106"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center</addr-line>,<institution>Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN 37232</addr-line>,<country>USA</country></nlm:aff></affiliation><affiliation><nlm:aff id="af129"><institution>International Epidemiology Institute</institution>,<addr-line>Rockville, MD 20850</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Signorello, Lisa B" sort="Signorello, Lisa B" uniqKey="Signorello L" first="Lisa B." last="Signorello">Lisa B. Signorello</name><affiliation><nlm:aff id="af106"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center</addr-line>,<institution>Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN 37232</addr-line>,<country>USA</country></nlm:aff></affiliation><affiliation><nlm:aff id="af129"><institution>International Epidemiology Institute</institution>,<addr-line>Rockville, MD 20850</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Cai, Qiuyin" sort="Cai, Qiuyin" uniqKey="Cai Q" first="Qiuyin" last="Cai">Qiuyin Cai</name><affiliation><nlm:aff id="af106"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center</addr-line>,<institution>Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN 37232</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB1 8RN</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Perkins, Barbara" sort="Perkins, Barbara" uniqKey="Perkins B" first="Barbara" last="Perkins">Barbara Perkins</name><affiliation><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB1 8RN</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name><affiliation><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB1 8RN</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Blows, Fiona M" sort="Blows, Fiona M" uniqKey="Blows F" first="Fiona M." last="Blows">Fiona M. Blows</name><affiliation><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB1 8RN</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Kang, Daehee" sort="Kang, Daehee" uniqKey="Kang D" first="Daehee" last="Kang">Daehee Kang</name><affiliation><nlm:aff id="af130"><addr-line>Department of Preventive Medicine</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af133"><addr-line>Department of Biomedical Sciences</addr-line>,<institution>Seoul National University Graduate School</institution>,<addr-line>Seoul 151-742</addr-line>,<country>Korea</country></nlm:aff></affiliation></author><author><name sortKey="Yoo, Keun Young" sort="Yoo, Keun Young" uniqKey="Yoo K" first="Keun-Young" last="Yoo">Keun-Young Yoo</name><affiliation><nlm:aff id="af132"><institution>Seoul National University College of Medicine</institution>,<addr-line>Seoul 110-799</addr-line>,<country>Korea</country></nlm:aff></affiliation></author><author><name sortKey="Noh, Dong Young" sort="Noh, Dong Young" uniqKey="Noh D" first="Dong-Young" last="Noh">Dong-Young Noh</name><affiliation><nlm:aff id="af131"><addr-line>Department of Surgery</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hartman, Mikael" sort="Hartman, Mikael" uniqKey="Hartman M" first="Mikael" last="Hartman">Mikael Hartman</name><affiliation><nlm:aff id="af134"><addr-line>Saw Swee Hock School of Public Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af135"><addr-line>Department of Surgery, Yong Loo Lin School of Medicine</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af137"><institution>National University Health System</institution>,<addr-line>Singapore 119228</addr-line>,<country>Singapore</country></nlm:aff></affiliation></author><author><name sortKey="Miao, Hui" sort="Miao, Hui" uniqKey="Miao H" first="Hui" last="Miao">Hui Miao</name><affiliation><nlm:aff id="af134"><addr-line>Saw Swee Hock School of Public Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af137"><institution>National University Health System</institution>,<addr-line>Singapore 119228</addr-line>,<country>Singapore</country></nlm:aff></affiliation></author><author><name sortKey="Chia, Kee Seng" sort="Chia, Kee Seng" uniqKey="Chia K" first="Kee Seng" last="Chia">Kee Seng Chia</name><affiliation><nlm:aff id="af134"><addr-line>Saw Swee Hock School of Public Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af137"><institution>National University Health System</institution>,<addr-line>Singapore 119228</addr-line>,<country>Singapore</country></nlm:aff></affiliation></author><author><name sortKey="Putti, Thomas Choudary" sort="Putti, Thomas Choudary" uniqKey="Putti T" first="Thomas Choudary" last="Putti">Thomas Choudary Putti</name><affiliation><nlm:aff id="af136"><addr-line>Department of Pathology, Yong Loo Lin School of Medicine</addr-line>,<institution>National University of Singapore</institution>,<addr-line>Singapore 117597</addr-line>,<country>Singapore</country></nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="af33"><addr-line>Molecular Genetics of Breast Cancer</addr-line></nlm:aff></affiliation></author><author><name sortKey="Luccarini, Craig" sort="Luccarini, Craig" uniqKey="Luccarini C" first="Craig" last="Luccarini">Craig Luccarini</name><affiliation><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB1 8RN</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Baynes, Caroline" sort="Baynes, Caroline" uniqKey="Baynes C" first="Caroline" last="Baynes">Caroline Baynes</name><affiliation><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB1 8RN</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Ahmed, Shahana" sort="Ahmed, Shahana" uniqKey="Ahmed S" first="Shahana" last="Ahmed">Shahana Ahmed</name><affiliation><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB1 8RN</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Maranian, Mel" sort="Maranian, Mel" uniqKey="Maranian M" first="Mel" last="Maranian">Mel Maranian</name><affiliation><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB1 8RN</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Healey, Catherine S" sort="Healey, Catherine S" uniqKey="Healey C" first="Catherine S." last="Healey">Catherine S. Healey</name><affiliation><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB1 8RN</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="af138"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin 70-204</addr-line>,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="af138"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin 70-204</addr-line>,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Jaworska Bieniek, Katarzyna" sort="Jaworska Bieniek, Katarzyna" uniqKey="Jaworska Bieniek K" first="Katarzyna" last="Jaworska-Bieniek">Katarzyna Jaworska-Bieniek</name><affiliation><nlm:aff id="af138"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin 70-204</addr-line>,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><affiliation><nlm:aff id="af138"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin 70-204</addr-line>,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Sangrajrang, Suleeporn" sort="Sangrajrang, Suleeporn" uniqKey="Sangrajrang S" first="Suleeporn" last="Sangrajrang">Suleeporn Sangrajrang</name><affiliation><nlm:aff id="af139"><institution>National Cancer Institute</institution>,<addr-line>Bangkok 10400</addr-line>,<country>Thailand</country></nlm:aff></affiliation></author><author><name sortKey="Gaborieau, Valerie" sort="Gaborieau, Valerie" uniqKey="Gaborieau V" first="Valerie" last="Gaborieau">Valerie Gaborieau</name><affiliation><nlm:aff id="af140"><institution>International Agency for Research on Cancer</institution>,<addr-line>Lyon 69372</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation><nlm:aff id="af140"><institution>International Agency for Research on Cancer</institution>,<addr-line>Lyon 69372</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Mckay, James" sort="Mckay, James" uniqKey="Mckay J" first="James" last="Mckay">James Mckay</name><affiliation><nlm:aff id="af140"><institution>International Agency for Research on Cancer</institution>,<addr-line>Lyon 69372</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Slager, Susan" sort="Slager, Susan" uniqKey="Slager S" first="Susan" last="Slager">Susan Slager</name><affiliation><nlm:aff id="af92"><addr-line>Department of Health Sciences Research</addr-line>,<institution>Mayo Clinic</institution>,<addr-line>Rochester, MN 55905</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name><affiliation><nlm:aff id="af141"><addr-line>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center</addr-line>,<institution>The Ohio State University</institution>,<addr-line>Columbus, OH 43210</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name><affiliation><nlm:aff id="af142"><addr-line>Molecular Diagnostics Laboratory</addr-line>,<institution>IRRP, National Centre for Scientific Research ‘Demokritos’</institution>,<addr-line>Aghia Paraskevi Attikis, Athens 153 10</addr-line>,<country>Greece</country></nlm:aff></affiliation></author><author><name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name><affiliation><nlm:aff id="af143"><addr-line>Institute of Biomedical Sciences</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af145"><institution>College of Public Health</institution>,<institution>China Medical University</institution>,<addr-line>Taichung 40402</addr-line>,<country>Taiwan</country></nlm:aff></affiliation></author><author><name sortKey="Hsiung, Chia Ni" sort="Hsiung, Chia Ni" uniqKey="Hsiung C" first="Chia-Ni" last="Hsiung">Chia-Ni Hsiung</name><affiliation><nlm:aff id="af143"><addr-line>Institute of Biomedical Sciences</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wu, Pei Ei" sort="Wu, Pei Ei" uniqKey="Wu P" first="Pei-Ei" last="Wu">Pei-Ei Wu</name><affiliation><nlm:aff id="af144"><addr-line>Taiwan Biobank, Institute of Biomedical Sciences</addr-line>,<institution>Academia Sinica</institution>,<addr-line>Taipei 115</addr-line>,<country>Taiwan</country></nlm:aff></affiliation></author><author><name sortKey="Ding, Shian Ling" sort="Ding, Shian Ling" uniqKey="Ding S" first="Shian-Ling" last="Ding">Shian-Ling Ding</name><affiliation><nlm:aff id="af146"><addr-line>Department of Nursing</addr-line>,<institution>Kang-Ning Junior College of Medical Care and Management</institution>,<addr-line>Taipei 11529</addr-line>,<country>Taiwan</country></nlm:aff></affiliation></author><author><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name><affiliation><nlm:aff id="af22"><addr-line>Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research</addr-line></nlm:aff></affiliation></author><author><name sortKey="Jones, Michael" sort="Jones, Michael" uniqKey="Jones M" first="Michael" last="Jones">Michael Jones</name><affiliation><nlm:aff id="af119"><addr-line>Division of Genetics and Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><affiliation><nlm:aff id="af23"><addr-line>Breakthrough Breast Cancer Research Centre and Division of Breast Cancer Research</addr-line>,<institution>The Institute of Cancer Research</institution>,<addr-line>London SW3 6JB</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony J" sort="Swerdlow, Anthony J" uniqKey="Swerdlow A" first="Anthony J" last="Swerdlow">Anthony J. Swerdlow</name><affiliation><nlm:aff id="af119"><addr-line>Division of Genetics and Epidemiology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af120"><addr-line>Division of Breast Cancer Research</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tsimiklis, Helen" sort="Tsimiklis, Helen" uniqKey="Tsimiklis H" first="Helen" last="Tsimiklis">Helen Tsimiklis</name><affiliation><nlm:aff id="af11"><addr-line>Genetic Epidemiology Laboratory, Department of Pathology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name><affiliation><nlm:aff id="af12"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>Melbourne, VIC 3010</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Schmidt, Daniel F" sort="Schmidt, Daniel F" uniqKey="Schmidt D" first="Daniel F." last="Schmidt">Daniel F. Schmidt</name><affiliation><nlm:aff id="af12"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>Melbourne, VIC 3010</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Bui, Quang M" sort="Bui, Quang M" uniqKey="Bui Q" first="Quang M." last="Bui">Quang M. Bui</name><affiliation><nlm:aff id="af12"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>Melbourne, VIC 3010</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="af122"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD 20850</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation><nlm:aff id="af147"><addr-line>Program in Molecular and Genetic Epidemiology</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston, MA 02115</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Hein, Rebecca" sort="Hein, Rebecca" uniqKey="Hein R" first="Rebecca" last="Hein">Rebecca Hein</name><affiliation><nlm:aff id="af34"><addr-line>Division of Cancer Epidemiology</addr-line>,<institution>German Cancer Research Center (DKFZ)</institution>,<addr-line>Heidelberg 69120</addr-line>,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="af148"><addr-line>PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy</addr-line>,<institution>University of Cologne</institution>,<addr-line>Cologne 50923</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Dahmen, Norbert" sort="Dahmen, Norbert" uniqKey="Dahmen N" first="Norbert" last="Dahmen">Norbert Dahmen</name><affiliation><nlm:aff id="af149"><addr-line>Department of Psychiatry</addr-line>,<institution>University of Mainz</institution>,<addr-line>Mainz 55122</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Beckmann, Lars" sort="Beckmann, Lars" uniqKey="Beckmann L" first="Lars" last="Beckmann">Lars Beckmann</name><affiliation><nlm:aff id="af150"><institution>Institute for Quality and Efficiency in Health Care (IQWiG)</institution>,<addr-line>Cologne 50670</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Aaltonen, Kirsimari" sort="Aaltonen, Kirsimari" uniqKey="Aaltonen K" first="Kirsimari" last="Aaltonen">Kirsimari Aaltonen</name><affiliation><nlm:aff id="af62"><addr-line>Department of Obstetrics and Gynecology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af65"><institution>Helsinki University Central Hospital</institution>,<addr-line>Helsinki 00029</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A." last="Muranen">Taru A. Muranen</name><affiliation><nlm:aff id="af62"><addr-line>Department of Obstetrics and Gynecology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af65"><institution>Helsinki University Central Hospital</institution>,<addr-line>Helsinki 00029</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Heikkinen, Tuomas" sort="Heikkinen, Tuomas" uniqKey="Heikkinen T" first="Tuomas" last="Heikkinen">Tuomas Heikkinen</name><affiliation><nlm:aff id="af62"><addr-line>Department of Obstetrics and Gynecology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af65"><institution>Helsinki University Central Hospital</institution>,<addr-line>Helsinki 00029</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Irwanto, Astrid" sort="Irwanto, Astrid" uniqKey="Irwanto A" first="Astrid" last="Irwanto">Astrid Irwanto</name><affiliation><nlm:aff id="af125"><addr-line>Human Genetics Division</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore 138672</addr-line>,<country>Singapore</country></nlm:aff></affiliation></author><author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><affiliation><nlm:aff id="af119"><addr-line>Division of Genetics and Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Turnbull, Clare A" sort="Turnbull, Clare A" uniqKey="Turnbull C" first="Clare A." last="Turnbull">Clare A. Turnbull</name><affiliation><nlm:aff id="af119"><addr-line>Division of Genetics and Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Waisfisz, Quinten" sort="Waisfisz, Quinten" uniqKey="Waisfisz Q" first="Quinten" last="Waisfisz">Quinten Waisfisz</name><affiliation><nlm:aff wicri:cut=" and" id="af151"><addr-line>Department of Clinical Genetics, Section Oncogenetics</addr-line>,<institution>VU University Medical Center</institution>,<addr-line>Amsterdam 1081 HZ</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Meijers Heijboer, Hanne E J" sort="Meijers Heijboer, Hanne E J" uniqKey="Meijers Heijboer H" first="Hanne E. J." last="Meijers-Heijboer">Hanne E. J. Meijers-Heijboer</name><affiliation><nlm:aff wicri:cut=" and" id="af151"><addr-line>Department of Clinical Genetics, Section Oncogenetics</addr-line>,<institution>VU University Medical Center</institution>,<addr-line>Amsterdam 1081 HZ</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Adank, Muriel A" sort="Adank, Muriel A" uniqKey="Adank M" first="Muriel A." last="Adank">Muriel A. Adank</name><affiliation><nlm:aff wicri:cut=" and" id="af151"><addr-line>Department of Clinical Genetics, Section Oncogenetics</addr-line>,<institution>VU University Medical Center</institution>,<addr-line>Amsterdam 1081 HZ</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Van Der Luijt, Rob B" sort="Van Der Luijt, Rob B" uniqKey="Van Der Luijt R" first="Rob B." last="Van Der Luijt">Rob B. Van Der Luijt</name><affiliation><nlm:aff id="af152"><addr-line>Department of Medical Genetics</addr-line>,<institution>University Medical Center Utrecht</institution>,<addr-line>Utrecht 3584 CX</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="af74"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm 17177</addr-line>,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="af6"><addr-line>Department of Genetics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison" sort="Dunning, Alison" uniqKey="Dunning A" first="Alison" last="Dunning">Alison Dunning</name><affiliation><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB1 8RN</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB1 8RN</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="af1"><addr-line>Department of Oncology</addr-line>,<institution>University of Sheffield Medical School</institution>,<addr-line>Sheffield S10 2RX</addr-line>,<country>UK</country></nlm:aff></affiliation></author></analytic><series><title level="j">Human Molecular Genetics</title><idno type="ISSN">0964-6906</idno><idno type="eISSN">1460-2083</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Previous studies have suggested that polymorphisms in <italic>CASP8</italic> on chromosome 2 are associated with breast cancer risk. To clarify the role of <italic>CASP8</italic> in breast cancer susceptibility, we carried out dense genotyping of this region in the Breast Cancer Association Consortium (BCAC). Single-nucleotide polymorphisms (SNPs) spanning a 1 Mb region around <italic>CASP8</italic> were genotyped in 46 450 breast cancer cases and 42 600 controls of European origin from 41 studies participating in the BCAC as part of a custom genotyping array experiment (iCOGS). Missing genotypes and SNPs were imputed and, after quality exclusions, 501 typed and 1232 imputed SNPs were included in logistic regression models adjusting for study and ancestry principal components. The SNPs retained in the final model were investigated further in data from nine genome-wide association studies (GWAS) comprising in total 10 052 case and 12 575 control subjects. The most significant association signal observed in European subjects was for the imputed intronic SNP rs1830298 in <italic>ALS2CR12</italic> (telomeric to <italic>CASP8</italic>), with per allele odds ratio and 95% confidence interval [OR (95% confidence interval, CI)] for the minor allele of 1.05 (1.03–1.07), <italic>P</italic> = 1 × 10<sup>−5</sup>. Three additional independent signals from intronic SNPs were identified, in <italic>CASP8</italic> (rs36043647), <italic>ALS2CR11</italic> (rs59278883) and <italic>CFLAR</italic> (rs7558475). The association with rs1830298 was replicated in the imputed results from the combined GWAS (<italic>P</italic> = 3 × 10<sup>−6</sup>), yielding a combined OR (95% CI) of 1.06 (1.04–1.08), <italic>P</italic> = 1 × 10<sup>−9</sup>. Analyses of gene expression associations in peripheral blood and normal breast tissue indicate that <italic>CASP8</italic> might be the target gene, suggesting a mechanism involving apoptosis.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Hum Mol Genet</journal-id><journal-id journal-id-type="iso-abbrev">Hum. Mol. Genet</journal-id><journal-id journal-id-type="publisher-id">hmg</journal-id><journal-id journal-id-type="hwp">hmg</journal-id><journal-title-group><journal-title>Human Molecular Genetics</journal-title></journal-title-group><issn pub-type="ppub">0964-6906</issn><issn pub-type="epub">1460-2083</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25168388</article-id><article-id pub-id-type="pmc">4334820</article-id><article-id pub-id-type="doi">10.1093/hmg/ddu431</article-id><article-id pub-id-type="publisher-id">ddu431</article-id><article-categories><subj-group subj-group-type="heading"><subject>Association Studies Articles</subject></subj-group></article-categories><title-group><article-title>Identification and characterization of novel associations in the <italic>CASP8/ALS2CR12</italic> region on chromosome 2 with breast cancer risk</article-title></title-group><contrib-group><contrib 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contrib-type="author"><name><surname>Dahmen</surname><given-names>Norbert</given-names></name><xref ref-type="aff" rid="af149">149</xref></contrib><contrib contrib-type="author"><name><surname>Beckmann</surname><given-names>Lars</given-names></name><xref ref-type="aff" rid="af150">150</xref></contrib><contrib contrib-type="author"><name><surname>Aaltonen</surname><given-names>Kirsimari</given-names></name><xref ref-type="aff" rid="af62">62</xref><xref ref-type="aff" rid="af65">65</xref></contrib><contrib contrib-type="author"><name><surname>Muranen</surname><given-names>Taru A.</given-names></name><xref ref-type="aff" rid="af62">62</xref><xref ref-type="aff" rid="af65">65</xref></contrib><contrib contrib-type="author"><name><surname>Heikkinen</surname><given-names>Tuomas</given-names></name><xref ref-type="aff" rid="af62">62</xref><xref ref-type="aff" rid="af65">65</xref></contrib><contrib contrib-type="author"><name><surname>Irwanto</surname><given-names>Astrid</given-names></name><xref ref-type="aff" rid="af125">125</xref></contrib><contrib contrib-type="author"><name><surname>Rahman</surname><given-names>Nazneen</given-names></name><xref ref-type="aff" rid="af119">119</xref></contrib><contrib contrib-type="author"><name><surname>Turnbull</surname><given-names>Clare A.</given-names></name><xref ref-type="aff" rid="af119">119</xref></contrib><contrib contrib-type="author"><collab>The Breast and Ovarian Cancer Susceptibility (BOCS) Study</collab><xref ref-type="aff" rid="af119">119</xref></contrib><contrib contrib-type="author"><name><surname>Waisfisz</surname><given-names>Quinten</given-names></name><xref ref-type="aff" rid="af151">151</xref></contrib><contrib contrib-type="author"><name><surname>Meijers-Heijboer</surname><given-names>Hanne E. J.</given-names></name><xref ref-type="aff" rid="af151">151</xref></contrib><contrib contrib-type="author"><name><surname>Adank</surname><given-names>Muriel A.</given-names></name><xref ref-type="aff" rid="af151">151</xref></contrib><contrib contrib-type="author"><name><surname>Van Der Luijt</surname><given-names>Rob B.</given-names></name><xref ref-type="aff" rid="af152">152</xref></contrib><contrib contrib-type="author"><name><surname>Hall</surname><given-names>Per</given-names></name><xref ref-type="aff" rid="af74">74</xref></contrib><contrib contrib-type="author"><name><surname>Chenevix-Trench</surname><given-names>Georgia</given-names></name><xref ref-type="aff" rid="af6">6</xref><xref ref-type="author-notes" rid="AN1">†</xref></contrib><contrib contrib-type="author"><name><surname>Dunning</surname><given-names>Alison</given-names></name><xref ref-type="aff" rid="af5">5</xref><xref ref-type="author-notes" rid="AN1">†</xref></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas F.</given-names></name><xref ref-type="aff" rid="af4">4</xref><xref ref-type="aff" rid="af5">5</xref><xref ref-type="author-notes" rid="AN1">†</xref></contrib><contrib contrib-type="author"><name><surname>Cox</surname><given-names>Angela</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="corresp" rid="cor1">*</xref><xref ref-type="author-notes" rid="AN1">†</xref></contrib><aff id="af1"><label>1</label><addr-line>Department of Oncology</addr-line>,<institution>University of Sheffield Medical School</institution>,<addr-line>Sheffield S10 2RX</addr-line>,<country>UK</country></aff><aff id="af2"><label>2</label><addr-line>Department of Neurosurgery</addr-line>,<institution>Chang Gung Memorial Hospital</institution>,<addr-line>Taoyuan County 333</addr-line>,<country>Taiwan</country></aff><aff id="af3"><label>3</label><addr-line>Department of Internal Medicine</addr-line>,<institution>University of Utah School of Medicine</institution>,<addr-line>Salt Lake City, UT 84108-1266</addr-line>,<country>USA</country></aff><aff id="af4"><label>4</label><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line></aff><aff id="af5"><label>5</label><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB1 8RN</addr-line>,<country>UK</country></aff><aff id="af6"><label>6</label><addr-line>Department of Genetics</addr-line></aff><aff id="af7"><label>7</label><institution>QIMR Berghofer Medical Research Institute</institution>,<addr-line>Brisbane 4006</addr-line>,<country>Australia</country></aff><aff id="af8"><label>8</label><addr-line>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health</addr-line></aff><aff id="af9"><label>9</label><addr-line>Department of Pathology</addr-line></aff><aff id="af10"><label>10</label><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health</addr-line></aff><aff id="af11"><label>11</label><addr-line>Genetic Epidemiology Laboratory, Department of Pathology</addr-line></aff><aff id="af12"><label>12</label><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>Melbourne, VIC 3010</addr-line>,<country>Australia</country></aff><aff id="af13"><label>13</label><addr-line>Netherlands Cancer Institute</addr-line>,<institution>Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam 1066 CX</addr-line>,<country>the Netherlands</country></aff><aff id="af14"><label>14</label><addr-line>Division of Health Sciences, Warwick Medical School</addr-line>,<institution>Warwick University</institution>,<addr-line>Coventry CV4 7AL</addr-line>,<country>UK</country></aff><aff id="af15"><label>15</label><addr-line>Institute of Population Health</addr-line>,<institution>University of Manchester</institution>,<addr-line>Manchester M13 9QQ</addr-line>,<country>UK</country></aff><aff id="af16"><label>16</label><addr-line>Ministry of Public Health, Nonthaburi 11000</addr-line>,<country>Thailand</country></aff><aff id="af17"><label>17</label><addr-line>University Breast Center Franconia, Department of Gynecology and Obstetrics</addr-line></aff><aff id="af18"><label>18</label><addr-line>Institute of Human Genetics</addr-line>,<institution>University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg</institution>,<addr-line>Erlangen D-91054</addr-line>,<country>Germany</country></aff><aff id="af19"><label>19</label><addr-line>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology</addr-line>,<institution>University of California</institution>,<addr-line>Los Angeles, CA 90095</addr-line>,<country>USA</country></aff><aff id="af20"><label>20</label><addr-line>Non-communicable Disease Epidemiology Department</addr-line>,<institution>London School of Hygiene and Tropical Medicine</institution>,<addr-line>London WC1E 7HT</addr-line>,<country>UK</country></aff><aff id="af21"><label>21</label><addr-line>Breakthrough Breast Cancer Research Centre</addr-line></aff><aff id="af22"><label>22</label><addr-line>Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research</addr-line></aff><aff id="af23"><label>23</label><addr-line>Breakthrough Breast Cancer Research Centre and Division of Breast Cancer Research</addr-line>,<institution>The Institute of Cancer Research</institution>,<addr-line>London SW3 6JB</addr-line>,<country>UK</country></aff><aff id="af24"><label>24</label><addr-line>Division of Cancer Studies</addr-line>,<institution>Kings College London</institution>,<institution>Guy's Hospital</institution>,<addr-line>London SE1 9RT</addr-line>,<country>UK</country></aff><aff id="af25"><label>25</label><addr-line>Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford OX3 7BN</addr-line>,<country>UK</country></aff><aff id="af26"><label>26</label><addr-line>School of Medicine, National University of Ireland</addr-line>,<country>Galway, Ireland</country></aff><aff id="af27"><label>27</label><addr-line>Department of Obstetrics and Gynecology</addr-line></aff><aff id="af28"><label>28</label><addr-line>National Center for Tumor Diseases</addr-line>,<institution>University of Heidelberg</institution>,<addr-line>Heidelberg 69117</addr-line>,<country>Germany</country></aff><aff id="af29"><label>29</label><addr-line>Molecular Epidemiology Group</addr-line></aff><aff id="af30"><label>30</label><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line></aff><aff id="af31"><label>31</label><addr-line>German Cancer Consortium (DKTK)</addr-line></aff><aff id="af32"><label>32</label><addr-line>Division of Cancer Epidemiology</addr-line></aff><aff id="af33"><label>33</label><addr-line>Molecular Genetics of Breast Cancer</addr-line></aff><aff id="af34"><label>34</label><addr-line>Division of Cancer Epidemiology</addr-line>,<institution>German Cancer Research Center (DKFZ)</institution>,<addr-line>Heidelberg 69120</addr-line>,<country>Germany</country></aff><aff id="af35"><label>35</label><addr-line>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health)</addr-line>,<institution>U1018, Environmental Epidemiology of Cancer</institution>,<addr-line>Villejuif 94807</addr-line>,<country>France</country></aff><aff id="af36"><label>36</label><institution>University Paris-Sud, UMRS 1018</institution>,<addr-line>Villejuif 94807</addr-line>,<country>France</country></aff><aff id="af37"><label>37</label><institution>Université Paris Sorbonne Cité, UMR-S775 Inserm</institution>,<addr-line>Paris 75015</addr-line>,<country>France</country></aff><aff id="af38"><label>38</label><addr-line>Copenhagen General Population Study</addr-line>,<institution>Herlev Hospital</institution>,<addr-line>2730 Herlev, Copenhagen</addr-line>,<country>Denmark</country></aff><aff id="af39"><label>39</label><addr-line>Department of Clinical Biochemistry</addr-line></aff><aff id="af40"><label>40</label><addr-line>Department of Breast Surgery</addr-line>,<institution>Herlev Hospital, Copenhagen University Hospital</institution>,<addr-line>Copenhagen 2100</addr-line>,<country>Denmark</country></aff><aff id="af41"><label>41</label><addr-line>Faculty of Health and Medical Sciences</addr-line>,<institution>University of Copenhagen</institution>,<addr-line>Copenhagen 2200</addr-line>,<country>Denmark</country></aff><aff id="af42"><label>42</label><addr-line>Human Genetics Group, Human Cancer Genetics Program</addr-line></aff><aff id="af43"><label>43</label><addr-line>Human Genotyping-CEGEN Unit, Human Cancer Genetics Program</addr-line>,<institution>Spanish National Cancer Research Centre (CNIO)</institution>,<addr-line>Madrid E-28029</addr-line>,<country>Spain</country></aff><aff id="af44"><label>44</label><institution>Centro de Investigación en Red de Enfermedades Raras (CIBERER)</institution>,<addr-line>Valencia 28029</addr-line>,<country>Spain</country></aff><aff id="af45"><label>45</label><addr-line>Servicio de Oncología Médica</addr-line>,<institution>Hospital Universitario La Paz</institution>,<addr-line>Madrid 28046</addr-line>,<country>Spain</country></aff><aff id="af46"><label>46</label><addr-line>Servicio de Cirugía General y Especialidades</addr-line></aff><aff id="af47"><label>47</label><addr-line>Servicio de Anatomía Patológica</addr-line>,<institution>Hospital Monte Naranco</institution>,<addr-line>Oviedo 33012</addr-line>,<country>Spain</country></aff><aff id="af48"><label>48</label><addr-line>Department of Epidemiology</addr-line>,<institution>University of California Irvine</institution>,<addr-line>Irvine, CA 92697</addr-line>,<country>USA</country></aff><aff id="af49"><label>49</label><institution>German Cancer Consortium (DKTK)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country></aff><aff id="af50"><label>50</label><institution>Saarland Cancer Registry</institution>,<addr-line>Saarbrücken 66024</addr-line>,<country>Germany</country></aff><aff id="af51"><label>51</label><addr-line>Division of Gynaecology and Obstetrics</addr-line></aff><aff id="af52"><label>52</label><addr-line>Insitute of Human Genetics</addr-line>,<institution>Technische Universität München</institution>,<addr-line>Munich D-80333</addr-line>,<country>Germany</country></aff><aff id="af53"><label>53</label><addr-line>Center for Hereditary Breast and Ovarian Cancer</addr-line>,<institution>Center for Integrated Oncology (CIO) and Center for Molecular Medicine Cologne (CMMC)</institution>,<addr-line>Medical Faculty, University of Cologne and University Hospital Cologne, 50932 Cologne</addr-line>,<country>Germany</country></aff><aff id="af54"><label>54</label><institution>Max Planck Institute of Psychiatry</institution>,<addr-line>Munich 80804</addr-line>,<country>Germany</country></aff><aff id="af55"><label>55</label><institution>Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology</institution>,<addr-line>Stuttgart 70376</addr-line>,<country>Germany</country></aff><aff id="af56"><label>56</label><institution>University of Tübingen</institution>,<addr-line>Tübingen 72074</addr-line>,<country>Germany</country></aff><aff id="af57"><label>57</label><addr-line>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance</addr-line>,<institution>Institute of the Ruhr-University Bochum (IPA)</institution>,<addr-line>Bochum D-44789</addr-line>,<country>Germany</country></aff><aff id="af58"><label>58</label><addr-line>Department of Internal Medicine</addr-line>,<institution>Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus</institution>,<addr-line>Bonn 53113</addr-line>,<country>Germany</country></aff><aff id="af59"><label>59</label><institution>Institute for Occupational Medicine and Maritime Medicine</institution>,<institution>University Medical Center Hamburg-Eppendorf</institution>,<addr-line>Hamburg 20246</addr-line>,<country>Germany</country></aff><aff id="af60"><label>60</label><addr-line>Institute of Pathology</addr-line>,<institution>Medical Faculty of the University of Bonn</institution>,<addr-line>Bonn 53127</addr-line>,<country>Germany</country></aff><aff id="af61"><label>61</label><institution>Centre D'innovation Génome Québec et Université McGill</institution>,<addr-line>Montréal, QC</addr-line>,<country>Canada</country><addr-line>H3A 0G1</addr-line></aff><aff id="af62"><label>62</label><addr-line>Department of Obstetrics and Gynecology</addr-line></aff><aff id="af63"><label>63</label><addr-line>Department of Clinical Genetics</addr-line></aff><aff id="af64"><label>64</label><addr-line>Department of Oncology, University of Helsinki</addr-line></aff><aff id="af65"><label>65</label><institution>Helsinki University Central Hospital</institution>,<addr-line>Helsinki 00029</addr-line>,<country>Finland</country></aff><aff id="af66"><label>66</label><addr-line>Department of Preventive Medicine</addr-line>,<institution>Kyushu University Faculty of Medical Sciences</institution>,<addr-line>Fukuoka 812-8582</addr-line>,<country>Japan</country></aff><aff id="af67"><label>67</label><addr-line>Division of Epidemiology and Prevention</addr-line>,<institution>Aichi Cancer Center Research Institute</institution>,<addr-line>Nagoya 464-8681</addr-line>,<country>Japan</country></aff><aff id="af68"><label>68</label><addr-line>Department of Breast Oncology</addr-line>,<institution>Aichi Cancer Center Hospital</institution>,<addr-line>Nagoya 464-8681</addr-line>,<country>Japan</country></aff><aff id="af69"><label>69</label><addr-line>Department of Obstetrics and Gynaecology</addr-line></aff><aff id="af70"><label>70</label><addr-line>Department of Radiation Oncology</addr-line>,<institution>Hannover Medical School</institution>,<addr-line>Hannover 30625</addr-line>,<country>Germany</country></aff><aff id="af71"><label>71</label><institution>N.N. Alexandrov Research Institute of Oncology and Medical Radiology</institution>,<addr-line>Minsk 223040</addr-line>,<country>Belarus</country></aff><aff id="af72"><label>72</label><addr-line>Department of Molecular Medicine and Surgery</addr-line></aff><aff id="af73"><label>73</label><addr-line>Department of Oncology–Pathology</addr-line></aff><aff id="af74"><label>74</label><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm 17177</addr-line>,<country>Sweden</country></aff><aff id="af75"><label>75</label><addr-line>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine</addr-line> and Cancer Center of Eastern Finland</aff><aff id="af76"><label>76</label><addr-line>School of Medicine, Institute of Clinical Medicine, Oncology</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio 70210</addr-line>,<country>Finland</country></aff><aff id="af77"><label>77</label><addr-line>Imaging Center, Department of Clinical Pathology</addr-line></aff><aff id="af78"><label>78</label><addr-line>Cancer Center</addr-line>,<institution>Kuopio University Hospital</institution>,<addr-line>Kuopio 70029</addr-line>,<country>Finland</country></aff><aff id="af79"><label>79</label><addr-line>Peter MacCallum Cancer Center, Melbourne, VIC 3002</addr-line>,<country>Australia</country></aff><aff id="af80"><label>80</label><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles, CA 90033</addr-line>,<country>USA</country></aff><aff id="af81"><label>81</label><institution>University Hospital Gashuisberg</institution>,<addr-line>Leuven 3000</addr-line>,<country>Belgium</country></aff><aff id="af82"><label>82</label><addr-line>Vesalius Research Center (VRC), VIB, Leuven 3000</addr-line>,<country>Belgium</country></aff><aff id="af83"><label>83</label><addr-line>Department of Oncology</addr-line></aff><aff id="af84"><label>84</label><addr-line>Laboratory for Translational Genetics, Department of Oncology</addr-line></aff><aff id="af85"><label>85</label><addr-line>Department of General Medical Oncology</addr-line>,<institution>University Hospitals Leuven</institution>,<addr-line>Leuven 3000</addr-line>,<country>Belgium</country></aff><aff id="af86"><label>86</label><addr-line>Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology</addr-line>,<institution>University Clinic Hamburg-Eppendorf</institution>,<addr-line>Hamburg D-20246</addr-line>,<country>Germany</country></aff><aff id="af87"><label>87</label><addr-line>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine</addr-line></aff><aff id="af88"><label>88</label><addr-line>Unit of Medical Genetics, Department of Preventive and Predictive Medicine</addr-line>,<institution>Fondazione IRCCS Istituto Nazionale dei Tumori (INT)</institution>,<addr-line>Milan 20133</addr-line>,<country>Italy</country></aff><aff id="af89"><label>89</label><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>,<addr-line>Milan 20139</addr-line>,<country>Italy</country></aff><aff id="af90"><label>90</label><addr-line>Division of Cancer Prevention and Genetics</addr-line>,<institution>Istituto Europeo di Oncologia (IEO)</institution>,<addr-line>Milan 20141</addr-line>,<country>Italy</country></aff><aff id="af91"><label>91</label><addr-line>Department of Laboratory Medicine and Pathology</addr-line></aff><aff id="af92"><label>92</label><addr-line>Department of Health Sciences Research</addr-line>,<institution>Mayo Clinic</institution>,<addr-line>Rochester, MN 55905</addr-line>,<country>USA</country></aff><aff id="af93"><label>93</label><addr-line>Karmanos Cancer Center, Detroit, MI 48201</addr-line>,<country>USA</country></aff><aff id="af94"><label>94</label><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>Cancer Council Victoria</institution>,<addr-line>Melbourne, VIC 3004</addr-line>,<country>Australia</country></aff><aff id="af95"><label>95</label><addr-line>Anatomical Pathology</addr-line>,<institution>The Alfred Hospital</institution>,<addr-line>Melbourne, VIC 3004</addr-line>,<country>Australia</country></aff><aff id="af96"><label>96</label><addr-line>Epidemiology Program</addr-line>,<institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI 96813</addr-line>,<country>USA</country></aff><aff id="af97"><label>97</label><institution>Centre Hospitalier Universitaire de Québec Research Centre and Laval University</institution>,<addr-line>Quebec City, QC</addr-line>,<country>Canada</country><addr-line>G1V 4G2</addr-line></aff><aff id="af98"><label>98</label><addr-line>Department of Medicine</addr-line>,<institution>McGill University</institution>,<addr-line>Montreal, QC</addr-line>,<country>Canada</country><addr-line>H3A 0G4</addr-line></aff><aff id="af99"><label>99</label><addr-line>Division of Clinical Epidemiology</addr-line>,<institution>McGill University Health Centre, Royal Victoria Hospital</institution>,<addr-line>Montreal, QC</addr-line>,<country>Canada</country><addr-line>H3A 1A1</addr-line></aff><aff id="af100"><label>100</label><addr-line>Départements de Santé Environnementale et Santé au Travail et de Médecine Sociale et Préventive, École de Santé Publique</addr-line>,<institution>Université de Montréal</institution>,<addr-line>Montreal, QC</addr-line>,<country>Canada</country><addr-line>H3T 1J4</addr-line></aff><aff id="af101"><label>101</label><addr-line>Cancer Research Initiatives Foundation</addr-line>,<institution>Sime Darby Medical Centre</institution>,<addr-line>Subang Jaya, Selangor</addr-line>,<country>Malaysia</country></aff><aff id="af102"><label>102</label><addr-line>Breast Cancer Research Unit</addr-line>,<institution>University Malaya Cancer Research Institute, University Malaya Medical Centre</institution>,<addr-line>Kuala Lumpur 50603</addr-line>,<country>Malaysia</country></aff><aff id="af103"><label>103</label><addr-line>Singapore Eye Research Institute</addr-line>,<institution>National University of Singapore</institution>,<addr-line>Singapore 119077</addr-line>,<country>Singapore</country></aff><aff id="af104"><label>104</label><addr-line>Department of Genetics, Institute for Cancer Research</addr-line>,<institution>Oslo University Hospital, Radiumhospitalet</institution>,<addr-line>Oslo 0372</addr-line>,<country>Norway</country></aff><aff id="af105"><label>105</label><addr-line>Faculty of Medicine (Faculty Division Ahus)</addr-line>,<institution>University of Oslo (UiO)</institution>,<addr-line>Oslo 0316</addr-line>,<country>Norway</country></aff><aff id="af106"><label>106</label><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center</addr-line>,<institution>Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN 37232</addr-line>,<country>USA</country></aff><aff id="af107"><label>107</label><addr-line>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, Northern Finland Laboratory Centre NordLab</addr-line></aff><aff id="af108"><label>108</label><addr-line>Department of Oncology</addr-line></aff><aff id="af109"><label>109</label><addr-line>Department of Pathology</addr-line>,<institution>Oulu University Hospital</institution>,<institution>University of Oulu</institution>,<addr-line>Oulu 90570</addr-line>,<country>Finland</country></aff><aff id="af110"><label>110</label><addr-line>Ontario Cancer Genetics Network</addr-line></aff><aff id="af111"><label>111</label><addr-line>Prosserman Centre for Health Research</addr-line></aff><aff id="af112"><label>112</label><institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto, ON</addr-line>,<country>Canada</country><addr-line>M5G 1X5</addr-line></aff><aff id="af113"><label>113</label><addr-line>Department of Molecular Genetics</addr-line></aff><aff id="af114"><label>114</label><addr-line>Division of Epidemiology, Dalla Lana School of Public Health</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto, ON</addr-line>,<country>Canada</country><addr-line>M5S 2J7</addr-line></aff><aff id="af115"><label>115</label><addr-line>Department of Human Genetics & Department of Pathology</addr-line></aff><aff id="af116"><label>116</label><addr-line>Department of Surgical Oncology</addr-line></aff><aff id="af117"><label>117</label><addr-line>Department of Clinical Genetics</addr-line>,<institution>Leiden University Medical Center</institution>,<addr-line>Leiden 2300 RC</addr-line>,<country>The Netherlands</country></aff><aff id="af118"><label>118</label><addr-line>Family Cancer Clinic, Department of Medical Oncology</addr-line>,<institution>Erasmus MC Cancer Institute</institution><addr-line>Rotterdam 3075 EA</addr-line>,<country>The Netherlands</country></aff><aff id="af119"><label>119</label><addr-line>Division of Genetics and Epidemiology</addr-line></aff><aff id="af120"><label>120</label><addr-line>Division of Breast Cancer Research</addr-line></aff><aff id="af121"><label>121</label><addr-line>Division of Cancer Genetics</addr-line>,<institution>The Institute of Cancer Research</institution>,<addr-line>London SW7 3RP</addr-line>,<country>UK</country></aff><aff id="af122"><label>122</label><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD 20850</addr-line>,<country>USA</country></aff><aff id="af123"><label>123</label><addr-line>Department of Cancer Epidemiology and Prevention</addr-line>,<institution>M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology</institution>,<addr-line>Warsaw 02-781</addr-line>,<country>Poland</country></aff><aff id="af124"><label>124</label><addr-line>Department of Clinical Genetics</addr-line>,<institution>Erasmus University Medical Center</institution>,<addr-line>Rotterdam 3075 EA</addr-line>,<country>The Netherlands</country></aff><aff id="af125"><label>125</label><addr-line>Human Genetics Division</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore 138672</addr-line>,<country>Singapore</country></aff><aff id="af126"><label>126</label><addr-line>Shanghai Center for Disease Control and Prevention, Shanghai 200336</addr-line>,<country>China</country></aff><aff id="af127"><label>127</label><addr-line>Department of Epidemiology</addr-line>,<institution>Shanghai Cancer Institute</institution>,<addr-line>Shanghai 220025</addr-line>,<country>China</country></aff><aff id="af128"><label>128</label><addr-line>Department of Neuroscience</addr-line>,<institution>University of Sheffield</institution>,<addr-line>Royal Hallamshire Hospital, Sheffield S10 2JF</addr-line>,<country>UK</country></aff><aff id="af129"><label>129</label><institution>International Epidemiology Institute</institution>,<addr-line>Rockville, MD 20850</addr-line>,<country>USA</country></aff><aff id="af130"><label>130</label><addr-line>Department of Preventive Medicine</addr-line></aff><aff id="af131"><label>131</label><addr-line>Department of Surgery</addr-line></aff><aff id="af132"><label>132</label><institution>Seoul National University College of Medicine</institution>,<addr-line>Seoul 110-799</addr-line>,<country>Korea</country></aff><aff id="af133"><label>133</label><addr-line>Department of Biomedical Sciences</addr-line>,<institution>Seoul National University Graduate School</institution>,<addr-line>Seoul 151-742</addr-line>,<country>Korea</country></aff><aff id="af134"><label>134</label><addr-line>Saw Swee Hock School of Public Health</addr-line></aff><aff id="af135"><label>135</label><addr-line>Department of Surgery, Yong Loo Lin School of Medicine</addr-line></aff><aff id="af136"><label>136</label><addr-line>Department of Pathology, Yong Loo Lin School of Medicine</addr-line>,<institution>National University of Singapore</institution>,<addr-line>Singapore 117597</addr-line>,<country>Singapore</country></aff><aff id="af137"><label>137</label><institution>National University Health System</institution>,<addr-line>Singapore 119228</addr-line>,<country>Singapore</country></aff><aff id="af138"><label>138</label><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin 70-204</addr-line>,<country>Poland</country></aff><aff id="af139"><label>139</label><institution>National Cancer Institute</institution>,<addr-line>Bangkok 10400</addr-line>,<country>Thailand</country></aff><aff id="af140"><label>140</label><institution>International Agency for Research on Cancer</institution>,<addr-line>Lyon 69372</addr-line>,<country>France</country></aff><aff id="af141"><label>141</label><addr-line>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center</addr-line>,<institution>The Ohio State University</institution>,<addr-line>Columbus, OH 43210</addr-line>,<country>USA</country></aff><aff id="af142"><label>142</label><addr-line>Molecular Diagnostics Laboratory</addr-line>,<institution>IRRP, National Centre for Scientific Research ‘Demokritos’</institution>,<addr-line>Aghia Paraskevi Attikis, Athens 153 10</addr-line>,<country>Greece</country></aff><aff id="af143"><label>143</label><addr-line>Institute of Biomedical Sciences</addr-line></aff><aff id="af144"><label>144</label><addr-line>Taiwan Biobank, Institute of Biomedical Sciences</addr-line>,<institution>Academia Sinica</institution>,<addr-line>Taipei 115</addr-line>,<country>Taiwan</country></aff><aff id="af145"><label>145</label><institution>College of Public Health</institution>,<institution>China Medical University</institution>,<addr-line>Taichung 40402</addr-line>,<country>Taiwan</country></aff><aff id="af146"><label>146</label><addr-line>Department of Nursing</addr-line>,<institution>Kang-Ning Junior College of Medical Care and Management</institution>,<addr-line>Taipei 11529</addr-line>,<country>Taiwan</country></aff><aff id="af147"><label>147</label><addr-line>Program in Molecular and Genetic Epidemiology</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston, MA 02115</addr-line>,<country>USA</country></aff><aff id="af148"><label>148</label><addr-line>PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy</addr-line>,<institution>University of Cologne</institution>,<addr-line>Cologne 50923</addr-line>,<country>Germany</country></aff><aff id="af149"><label>149</label><addr-line>Department of Psychiatry</addr-line>,<institution>University of Mainz</institution>,<addr-line>Mainz 55122</addr-line>,<country>Germany</country></aff><aff id="af150"><label>150</label><institution>Institute for Quality and Efficiency in Health Care (IQWiG)</institution>,<addr-line>Cologne 50670</addr-line>,<country>Germany</country></aff><aff id="af151"><label>151</label><addr-line>Department of Clinical Genetics, Section Oncogenetics</addr-line>,<institution>VU University Medical Center</institution>,<addr-line>Amsterdam 1081 HZ</addr-line>,<country>The Netherlands</country> and</aff><aff id="af152"><label>152</label><addr-line>Department of Medical Genetics</addr-line>,<institution>University Medical Center Utrecht</institution>,<addr-line>Utrecht 3584 CX</addr-line>,<country>The Netherlands</country></aff></contrib-group><author-notes><corresp id="cor1"><label>*</label>To whom correspondence should be addressed at: Sheffield University Medical School, Beech Hill Road, Sheffield S10 2RX, UK. Tel: +44 1142712373; Fax: +44 1142711602; Email: <email>a.cox@sheffield.ac.uk</email></corresp><fn id="AN1" fn-type="con"><label>†</label><p>The authors wish it to be known that, in their opinion, the first 2 and 4 final authors should be regarded as having contributed equally to this work.</p></fn></author-notes><pub-date pub-type="ppub"><day>01</day><month>1</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>28</day><month>8</month><year>2014</year></pub-date><volume>24</volume><issue>1</issue><fpage>285</fpage><lpage>298</lpage><history><date date-type="received"><day>28</day><month>5</month><year>2014</year></date><date date-type="rev-recd"><day>30</day><month>7</month><year>2014</year></date><date date-type="accepted"><day>20</day><month>8</month><year>2014</year></date></history><permissions><copyright-statement>© The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com</copyright-statement><copyright-year>2014</copyright-year></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="ddu431.pdf"></self-uri><abstract><p>Previous studies have suggested that polymorphisms in <italic>CASP8</italic> on chromosome 2 are associated with breast cancer risk. To clarify the role of <italic>CASP8</italic> in breast cancer susceptibility, we carried out dense genotyping of this region in the Breast Cancer Association Consortium (BCAC). Single-nucleotide polymorphisms (SNPs) spanning a 1 Mb region around <italic>CASP8</italic> were genotyped in 46 450 breast cancer cases and 42 600 controls of European origin from 41 studies participating in the BCAC as part of a custom genotyping array experiment (iCOGS). Missing genotypes and SNPs were imputed and, after quality exclusions, 501 typed and 1232 imputed SNPs were included in logistic regression models adjusting for study and ancestry principal components. The SNPs retained in the final model were investigated further in data from nine genome-wide association studies (GWAS) comprising in total 10 052 case and 12 575 control subjects. The most significant association signal observed in European subjects was for the imputed intronic SNP rs1830298 in <italic>ALS2CR12</italic> (telomeric to <italic>CASP8</italic>), with per allele odds ratio and 95% confidence interval [OR (95% confidence interval, CI)] for the minor allele of 1.05 (1.03–1.07), <italic>P</italic> = 1 × 10<sup>−5</sup>. Three additional independent signals from intronic SNPs were identified, in <italic>CASP8</italic> (rs36043647), <italic>ALS2CR11</italic> (rs59278883) and <italic>CFLAR</italic> (rs7558475). The association with rs1830298 was replicated in the imputed results from the combined GWAS (<italic>P</italic> = 3 × 10<sup>−6</sup>), yielding a combined OR (95% CI) of 1.06 (1.04–1.08), <italic>P</italic> = 1 × 10<sup>−9</sup>. Analyses of gene expression associations in peripheral blood and normal breast tissue indicate that <italic>CASP8</italic> might be the target gene, suggesting a mechanism involving apoptosis.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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