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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46 450 cases and 42 461 controls from the breast cancer association consortium</title><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Human Cancer Genetics Programme</addr-line></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af3"><addr-line>Centre for Epidemiology and Biostatistics, School of Population Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af5"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Herranz, Jesus" sort="Herranz, Jesus" uniqKey="Herranz J" first="Jesús" last="Herranz">Jesús Herranz</name><affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Human Cancer Genetics Programme</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af6"><addr-line>Biostatistics Unit</addr-line>,<institution>IMDEA Food Institute</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff wicri:cut=" and" id="af7"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation><nlm:aff wicri:cut=" and" id="af7"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tyrer, Jonathan P" sort="Tyrer, Jonathan P" uniqKey="Tyrer J" first="Jonathan P." last="Tyrer">Jonathan P. Tyrer</name><affiliation><nlm:aff id="af8"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Zamora, M Pilar" sort="Zamora, M Pilar" uniqKey="Zamora M" first="M. Pilar" last="Zamora">M. Pilar Zamora</name><affiliation><nlm:aff id="af9"><addr-line>Servicio de Oncología Médica</addr-line>,<institution>Hospital Universitario La Paz</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Arias Perez, Jose Ignacio" sort="Arias Perez, Jose Ignacio" uniqKey="Arias Perez J" first="José Ignacio" last="Arias-Perez">José Ignacio Arias-Perez</name><affiliation><nlm:aff id="af10"><addr-line>Servicio de Cirugía General y Especialidades</addr-line>,<institution>Hospital Monte Naranco</institution>,<addr-line>Oviedo</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name><affiliation><nlm:aff id="af2"><addr-line>Human Genotyping-CEGEN Unit</addr-line>,<institution>Spanish National Cancer Research Centre (CNIO)</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Pita, Guillermo" sort="Pita, Guillermo" uniqKey="Pita G" first="Guillermo" last="Pita">Guillermo Pita</name><affiliation><nlm:aff id="af2"><addr-line>Human Genotyping-CEGEN Unit</addr-line>,<institution>Spanish National Cancer Research Centre (CNIO)</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Alonso, M Rosario" sort="Alonso, M Rosario" uniqKey="Alonso M" first="M. Rosario" last="Alonso">M. Rosario Alonso</name><affiliation><nlm:aff id="af2"><addr-line>Human Genotyping-CEGEN Unit</addr-line>,<institution>Spanish National Cancer Research Centre (CNIO)</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff wicri:cut=" and" id="af7"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name><affiliation><nlm:aff wicri:cut=" and" id="af7"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line></nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="af11"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Eriksson, Mikael" sort="Eriksson, Mikael" uniqKey="Eriksson M" first="Mikael" last="Eriksson">Mikael Eriksson</name><affiliation><nlm:aff id="af11"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name><affiliation><nlm:aff id="af11"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name><affiliation><nlm:aff id="af11"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation><nlm:aff id="af14"><addr-line>Human Genetics Division</addr-line>,<institution>Genome Institute of Singapore</institution>,<country>Singapore</country></nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="af15"><addr-line>Department of Epidemiology</addr-line>,<institution>University of California Irvine</institution>,<addr-line>Irvine, CA</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation><nlm:aff id="af16"><institution>Beckman Research Institute</institution>,<addr-line>City of Hope, Duarte, CA</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name><affiliation><nlm:aff id="af15"><addr-line>Department of Epidemiology</addr-line>,<institution>University of California Irvine</institution>,<addr-line>Irvine, CA</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Clarke, Christina A" sort="Clarke, Christina A" uniqKey="Clarke C" first="Christina A." last="Clarke">Christina A. Clarke</name><affiliation><nlm:aff id="af17"><institution>Cancer Prevention Institute of California</institution>,<addr-line>Fremont, CA</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff wicri:cut=" and" id="af3"><addr-line>Centre for Epidemiology and Biostatistics, School of Population Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dite, Gillian S" sort="Dite, Gillian S" uniqKey="Dite G" first="Gillian S." last="Dite">Gillian S. Dite</name><affiliation><nlm:aff wicri:cut=" and" id="af3"><addr-line>Centre for Epidemiology and Biostatistics, School of Population Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation><nlm:aff wicri:cut=" and" id="af3"><addr-line>Centre for Epidemiology and Biostatistics, School of Population Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="af4"><addr-line>Department of Pathology</addr-line>,<institution>University of Melbourne</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="af18"><institution>QIMR Berghofer Medical Research Institute</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation><nlm:aff id="af20"><addr-line>Division of Genetics and Epidemiology</addr-line>,<institution>The Institute of Cancer Research</institution>,<addr-line>Sutton</addr-line>,<country>UK</country></nlm:aff></affiliation><affiliation><nlm:aff id="af21"><addr-line>Division of Breast Cancer Research</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name><affiliation><nlm:aff id="af21"><addr-line>Division of Breast Cancer Research</addr-line></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af22"><addr-line>Breakthrough Breast Cancer Research Centre</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af23"><addr-line>Division of Molecular Pathology</addr-line>,<institution>The Institute of Cancer Research</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Orr, Nicholas" sort="Orr, Nicholas" uniqKey="Orr N" first="Nicholas" last="Orr">Nicholas Orr</name><affiliation><nlm:aff id="af21"><addr-line>Division of Breast Cancer Research</addr-line></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af22"><addr-line>Breakthrough Breast Cancer Research Centre</addr-line></nlm:aff></affiliation></author><author><name sortKey="Schoemaker, Minouk" sort="Schoemaker, Minouk" uniqKey="Schoemaker M" first="Minouk" last="Schoemaker">Minouk Schoemaker</name><affiliation><nlm:aff id="af20"><addr-line>Division of Genetics and Epidemiology</addr-line>,<institution>The Institute of Cancer Research</institution>,<addr-line>Sutton</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="af24"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="af24"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Jaworska Bieniek, Katarzyna" sort="Jaworska Bieniek, Katarzyna" uniqKey="Jaworska Bieniek K" first="Katarzyna" last="Jaworska-Bieniek">Katarzyna Jaworska-Bieniek</name><affiliation><nlm:aff id="af24"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country></nlm:aff></affiliation><affiliation><nlm:aff id="af25"><addr-line>Postgraduate School of Molecular Medicine</addr-line>,<institution>Warsaw Medical University</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><affiliation><nlm:aff id="af24"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="af26"><addr-line>Lunenfeld-Tanenbaum Research Institute</addr-line>,<institution>Mount Sinai Hospital</institution>,<addr-line>Toronto, Ontario</addr-line>,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="af27"><addr-line>Department of Molecular Genetics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name><affiliation><nlm:aff id="af26"><addr-line>Lunenfeld-Tanenbaum Research Institute</addr-line>,<institution>Mount Sinai Hospital</institution>,<addr-line>Toronto, Ontario</addr-line>,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af28"><addr-line>Division of Epidemiology, Dalla Lana School of Public Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="af30"><addr-line>Ontario Cancer Genetics Network</addr-line>,<institution>Lunenfeld-Tanenbaum Research Institute</institution>,<addr-line>Toronto, Ontario</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation><nlm:aff id="af29"><addr-line>Department of Laboratory Medicine and Pathobiology</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto, Ontario</addr-line>,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="af31"><addr-line>Laboratory Medicine Program</addr-line>,<institution>University Health Network</institution>,<addr-line>Toronto, Ontario</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="af32"><addr-line>Copenhagen General Population Study</addr-line></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af33"><addr-line>Department of Clinical Biochemistry</addr-line></nlm:aff></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation><nlm:aff id="af32"><addr-line>Copenhagen General Population Study</addr-line></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af33"><addr-line>Department of Clinical Biochemistry</addr-line></nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="af34"><addr-line>Department of Breast Surgery</addr-line>,<institution>Herlev University Hospital, University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="af35"><addr-line>Department of Obstetrics and Gynecology</addr-line>,<institution>University of Helsinki and Helsinki University Central Hospital</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A." last="Muranen">Taru A. Muranen</name><affiliation><nlm:aff id="af35"><addr-line>Department of Obstetrics and Gynecology</addr-line>,<institution>University of Helsinki and Helsinki University Central Hospital</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff wicri:cut=" and" id="af36"><addr-line>Department of Clinical Genetics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation><nlm:aff id="af37"><addr-line>Department of Oncology</addr-line>,<institution>Helsinki University Central Hospital</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="af38"><addr-line>Division of Cancer Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="af38"><addr-line>Division of Cancer Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Seibold, Petra" sort="Seibold, Petra" uniqKey="Seibold P" first="Petra" last="Seibold">Petra Seibold</name><affiliation><nlm:aff id="af38"><addr-line>Division of Cancer Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff wicri:cut=" and" id="af42"><addr-line>Department of Cancer Epidemiology/Clinical Cancer Registry</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af43"><addr-line>Institute for Medical Biometrics and Epidemiology</addr-line>,<institution>University Clinic Hamburg-Eppendorf</institution>,<addr-line>Hamburg</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><nlm:aff wicri:cut=" and" id="af44"><addr-line>Department of Laboratory Medicine and Pathology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><affiliation><nlm:aff id="af45"><addr-line>Department of Health Sciences Research</addr-line>,<institution>Mayo Clinic</institution>,<addr-line>Rochester, MN</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name><affiliation><nlm:aff id="af45"><addr-line>Department of Health Sciences Research</addr-line>,<institution>Mayo Clinic</institution>,<addr-line>Rochester, MN</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Purrington, Kristen" sort="Purrington, Kristen" uniqKey="Purrington K" first="Kristen" last="Purrington">Kristen Purrington</name><affiliation><nlm:aff id="af45"><addr-line>Department of Health Sciences Research</addr-line>,<institution>Mayo Clinic</institution>,<addr-line>Rochester, MN</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="af46"><addr-line>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation><nlm:aff id="af46"><addr-line>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu</addr-line></nlm:aff></affiliation></author><author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name><affiliation><nlm:aff wicri:cut=" and" id="af47"><addr-line>Department of Oncology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Grip, Mervi" sort="Grip, Mervi" uniqKey="Grip M" first="Mervi" last="Grip">Mervi Grip</name><affiliation><nlm:aff id="af48"><addr-line>Department of Surgery</addr-line>,<institution>Oulu University Hospital, University of Oulu</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="af8"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name><affiliation><nlm:aff id="af8"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation><nlm:aff id="af49"><addr-line>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018</addr-line>,<institution>Environmental Epidemiology of Cancer</institution>,<addr-line>Villejuif</addr-line>,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af50"><institution>University Paris-Sud</institution>,<addr-line>UMRS 1018, Villejuif</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation><nlm:aff id="af49"><addr-line>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018</addr-line>,<institution>Environmental Epidemiology of Cancer</institution>,<addr-line>Villejuif</addr-line>,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af50"><institution>University Paris-Sud</institution>,<addr-line>UMRS 1018, Villejuif</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Sanchez, Marie" sort="Sanchez, Marie" uniqKey="Sanchez M" first="Marie" last="Sanchez">Marie Sanchez</name><affiliation><nlm:aff id="af49"><addr-line>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018</addr-line>,<institution>Environmental Epidemiology of Cancer</institution>,<addr-line>Villejuif</addr-line>,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af50"><institution>University Paris-Sud</institution>,<addr-line>UMRS 1018, Villejuif</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Mulot, Claire" sort="Mulot, Claire" uniqKey="Mulot C" first="Claire" last="Mulot">Claire Mulot</name><affiliation><nlm:aff id="af51"><institution>Centre de Ressources Biologiques EPIGENETEC</institution>,<addr-line>Paris</addr-line>,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af52"><institution>Inserm (National Institute of Health and Medical Research)</institution>,<addr-line>U775, Paris</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="af39"><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af53"><institution>German Cancer Consortium (DKTK)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Dieffenbach, Aida Karina" sort="Dieffenbach, Aida Karina" uniqKey="Dieffenbach A" first="Aida Karina" last="Dieffenbach">Aida Karina Dieffenbach</name><affiliation><nlm:aff id="af39"><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af53"><institution>German Cancer Consortium (DKTK)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="af39"><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name><affiliation><nlm:aff id="af54"><institution>Saarland Cancer Registry</institution>,<addr-line>Saarbrücken</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff wicri:cut=" and" id="af12"><addr-line>Department of Molecular Medicine and Surgery</addr-line></nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation><nlm:aff id="af13"><addr-line>Department of Oncology - Pathology</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm</addr-line>,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name><affiliation><nlm:aff wicri:cut=" and" id="af55"><addr-line>Department of Medical Oncology, Family Cancer Clinic</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation><nlm:aff wicri:cut=" and" id="af55"><addr-line>Department of Medical Oncology, Family Cancer Clinic</addr-line></nlm:aff></affiliation></author><author><name sortKey="Collee, J Margriet" sort="Collee, J Margriet" uniqKey="Collee J" first="J. Margriet" last="Collée">J. Margriet Collée</name><affiliation><nlm:aff id="af56"><addr-line>Department of Clinical Genetics, Family Cancer Clinic</addr-line>,<institution>Erasmus University Medical Center</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Jager, Agnes" sort="Jager, Agnes" uniqKey="Jager A" first="Agnes" last="Jager">Agnes Jager</name><affiliation><nlm:aff wicri:cut=" and" id="af55"><addr-line>Department of Medical Oncology, Family Cancer Clinic</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="af57"><addr-line>CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology</addr-line>,<institution>University of Sheffield</institution>,<addr-line>Sheffield</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Brock, Ian W" sort="Brock, Ian W" uniqKey="Brock I" first="Ian W." last="Brock">Ian W. Brock</name><affiliation><nlm:aff id="af57"><addr-line>CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology</addr-line>,<institution>University of Sheffield</institution>,<addr-line>Sheffield</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Reed, Malcolm W R" sort="Reed, Malcolm W R" uniqKey="Reed M" first="Malcolm W. R." last="Reed">Malcolm W. R. Reed</name><affiliation><nlm:aff id="af57"><addr-line>CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology</addr-line>,<institution>University of Sheffield</institution>,<addr-line>Sheffield</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:aff id="af58"><addr-line>Department of Human Genetics</addr-line></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af59"><addr-line>Department of Pathology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tollenaar, Robert A E M" sort="Tollenaar, Robert A E M" uniqKey="Tollenaar R" first="Robert A. E. M." last="Tollenaar">Robert A. E. M. Tollenaar</name><affiliation><nlm:aff id="af60"><addr-line>Department of Surgical Oncology</addr-line>,<institution>Leiden University Medical Center</institution>,<addr-line>Leiden</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name><affiliation><nlm:aff wicri:cut=" and" id="af55"><addr-line>Department of Medical Oncology, Family Cancer Clinic</addr-line></nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="af61"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation><nlm:aff id="af61"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Schumacher, Fredrick" sort="Schumacher, Fredrick" uniqKey="Schumacher F" first="Fredrick" last="Schumacher">Fredrick Schumacher</name><affiliation><nlm:aff id="af61"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="af62"><institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="af63"><addr-line>Cancer Genomics Laboratory</addr-line>,<institution>Centre Hospitalier Universitaire de Quebec Research Center and Laval University</institution>,<addr-line>Quebec</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name><affiliation><nlm:aff id="af63"><addr-line>Cancer Genomics Laboratory</addr-line>,<institution>Centre Hospitalier Universitaire de Quebec Research Center and Laval University</institution>,<addr-line>Quebec</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name><affiliation><nlm:aff id="af63"><addr-line>Cancer Genomics Laboratory</addr-line>,<institution>Centre Hospitalier Universitaire de Quebec Research Center and Laval University</institution>,<addr-line>Quebec</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff wicri:cut=" and" id="af64"><addr-line>Department of Obstetrics and Gynaecology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name><affiliation><nlm:aff wicri:cut=" and" id="af64"><addr-line>Department of Obstetrics and Gynaecology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af65"><addr-line>Department of Radiation Oncology</addr-line>,<institution>Hannover Medical School</institution>,<addr-line>Hannover</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="af66"><addr-line>Molecular Genetics of Breast Cancer</addr-line>,<institution>Deutsches Krebsforschungszentrum (DKFZ)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Forsti, Asta" sort="Forsti, Asta" uniqKey="Forsti A" first="Asta" last="Försti">Asta Försti</name><affiliation><nlm:aff wicri:cut=" and" id="af40"><addr-line>Division of Molecular Genetic Epidemiology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af67"><addr-line>Center for Primary Health Care Research</addr-line>,<institution>Lund University</institution>,<addr-line>Malmö</addr-line>,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Rudiger, Thomas" sort="Rudiger, Thomas" uniqKey="Rudiger T" first="Thomas" last="Rüdiger">Thomas Rüdiger</name><affiliation><nlm:aff id="af68"><institution>Institute of Pathology, Städtisches Klinikum Karlsruhe</institution>,<addr-line>Karlsruhe</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Ulmer, Hans Ulrich" sort="Ulmer, Hans Ulrich" uniqKey="Ulmer H" first="Hans-Ulrich" last="Ulmer">Hans-Ulrich Ulmer</name><affiliation><nlm:aff id="af69"><institution>Frauenklinik der Stadtklinik Baden-Baden</institution>,<addr-line>Baden-Baden</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="af70"><addr-line>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen</addr-line>,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="af71"><addr-line>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology</addr-line>,<institution>University of California at Los Angeles</institution>,<addr-line>Los Angeles</addr-line><addr-line>, CA</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="H Berle, Lothar" sort="H Berle, Lothar" uniqKey="H Berle L" first="Lothar" last="H Berle">Lothar H Berle</name><affiliation><nlm:aff id="af70"><addr-line>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation><nlm:aff id="af72"><addr-line>Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="af70"><addr-line>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff wicri:cut=" and" id="af22"><addr-line>Breakthrough Breast Cancer Research Centre</addr-line></nlm:aff></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation><nlm:aff wicri:cut=" and" id="af22"><addr-line>Breakthrough Breast Cancer Research Centre</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos Santos Silva">Isabel Dos Santos Silva</name><affiliation><nlm:aff id="af73"><institution>London School of Hygiene and Tropical Medicine</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="af73"><institution>London School of Hygiene and Tropical Medicine</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff wicri:cut=" and" id="af74"><addr-line>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="af76"><addr-line>IFOM</addr-line>,<institution>Fondazione Istituto FIRC di Oncologia Molecolare</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Peissel, Bernard" sort="Peissel, Bernard" uniqKey="Peissel B" first="Bernard" last="Peissel">Bernard Peissel</name><affiliation><nlm:aff id="af75"><addr-line>Unit of Medical Genetics, Department of Preventive and Predictive Medicine</addr-line>,<institution>Fondazione IRCCS Istituto Nazionale dei Tumori (INT)</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Mariani, Paolo" sort="Mariani, Paolo" uniqKey="Mariani P" first="Paolo" last="Mariani">Paolo Mariani</name><affiliation><nlm:aff id="af76"><addr-line>IFOM</addr-line>,<institution>Fondazione Istituto FIRC di Oncologia Molecolare</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff></affiliation><affiliation><nlm:aff id="af77"><institution>Cogentech Cancer Genetic Test Laboratory</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff wicri:cut=" and" id="af3"><addr-line>Centre for Epidemiology and Biostatistics, School of Population Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af5"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff wicri:cut=" and" id="af3"><addr-line>Centre for Epidemiology and Biostatistics, School of Population Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af5"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation><nlm:aff wicri:cut=" and" id="af3"><addr-line>Centre for Epidemiology and Biostatistics, School of Population Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af5"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor" sort="Sawyer, Elinor" uniqKey="Sawyer E" first="Elinor" last="Sawyer">Elinor Sawyer</name><affiliation><nlm:aff id="af78"><addr-line>Division of Cancer Studies</addr-line>,<institution>NIHR Comprehensive Biomedical Research Centre, Guy's & St. Thomas’ NHS Foundation Trust in Partnership with King's College London</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation><nlm:aff wicri:cut=" and" id="af79"><addr-line>Wellcome Trust Centre for Human Genetics</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af80"><addr-line>Oxford Biomedical Research Centre</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Kerin, Michael" sort="Kerin, Michael" uniqKey="Kerin M" first="Michael" last="Kerin">Michael Kerin</name><affiliation><nlm:aff id="af81"><addr-line>School of Medicine, Clinical Science Institute</addr-line>,<institution>National University of Ireland</institution>,<addr-line>Galway</addr-line>,<country>Ireland</country></nlm:aff></affiliation></author><author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name><affiliation><nlm:aff id="af81"><addr-line>School of Medicine, Clinical Science Institute</addr-line>,<institution>National University of Ireland</institution>,<addr-line>Galway</addr-line>,<country>Ireland</country></nlm:aff></affiliation></author><author><name sortKey="Marme, Federik" sort="Marme, Federik" uniqKey="Marme F" first="Federik" last="Marme">Federik Marme</name><affiliation><nlm:aff wicri:cut=" and" id="af82"><addr-line>Department of Obstetrics and Gynecology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af83"><addr-line>National Center for Tumor Diseases</addr-line>,<institution>University of Heidelberg</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="af41"><addr-line>Molecular Epidemiology Group</addr-line>,<institution>German Cancer Research Center (DKFZ)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af82"><addr-line>Department of Obstetrics and Gynecology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff wicri:cut=" and" id="af84"><addr-line>Department of Clinical Pathology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af86"><addr-line>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af87"><addr-line>Biocenter Kuopio</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name><affiliation><nlm:aff id="af85"><institution>Cancer Center, Kuopio University Hospital</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af86"><addr-line>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af87"><addr-line>Biocenter Kuopio</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff wicri:cut=" and" id="af84"><addr-line>Department of Clinical Pathology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af86"><addr-line>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af87"><addr-line>Biocenter Kuopio</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M." last="Hartikainen">Jaana M. Hartikainen</name><affiliation><nlm:aff wicri:cut=" and" id="af84"><addr-line>Department of Clinical Pathology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af86"><addr-line>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af87"><addr-line>Biocenter Kuopio</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="af88"><institution>Vesalius Research Center (VRC), VIB</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Yesilyurt, Betul T" sort="Yesilyurt, Betul T" uniqKey="Yesilyurt B" first="Betul T." last="Yesilyurt">Betul T. Yesilyurt</name><affiliation><nlm:aff id="af88"><institution>Vesalius Research Center (VRC), VIB</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Floris, Giuseppe" sort="Floris, Giuseppe" uniqKey="Floris G" first="Giuseppe" last="Floris">Giuseppe Floris</name><affiliation><nlm:aff id="af89"><addr-line>Multidisciplinary Breast Center</addr-line>,<institution>University Hospital Gasthuisberg</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Leunen, Karin" sort="Leunen, Karin" uniqKey="Leunen K" first="Karin" last="Leunen">Karin Leunen</name><affiliation><nlm:aff id="af89"><addr-line>Multidisciplinary Breast Center</addr-line>,<institution>University Hospital Gasthuisberg</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Aln S, Grethe Grenaker" sort="Aln S, Grethe Grenaker" uniqKey="Aln S G" first="Grethe Grenaker" last="Aln S">Grethe Grenaker Aln S</name><affiliation><nlm:aff id="af90"><addr-line>Department of Genetics</addr-line>,<institution>Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country></nlm:aff></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation><nlm:aff id="af90"><addr-line>Department of Genetics</addr-line>,<institution>Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country></nlm:aff></affiliation><affiliation><nlm:aff id="af91"><addr-line>Faculty of Medicine (Faculty Division Ahus)</addr-line>,<institution>UiO</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country></nlm:aff></affiliation></author><author><name sortKey="B Rresen Dale, Anne Lise" sort="B Rresen Dale, Anne Lise" uniqKey="B Rresen Dale A" first="Anne-Lise" last="B Rresen-Dale">Anne-Lise B Rresen-Dale</name><affiliation><nlm:aff id="af90"><addr-line>Department of Genetics</addr-line>,<institution>Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country></nlm:aff></affiliation><affiliation><nlm:aff id="af91"><addr-line>Faculty of Medicine (Faculty Division Ahus)</addr-line>,<institution>UiO</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country></nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation><nlm:aff id="af20"><addr-line>Division of Genetics and Epidemiology</addr-line>,<institution>The Institute of Cancer Research</institution>,<addr-line>Sutton</addr-line>,<country>UK</country></nlm:aff></affiliation><affiliation><nlm:aff id="af21"><addr-line>Division of Breast Cancer Research</addr-line></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af22"><addr-line>Breakthrough Breast Cancer Research Centre</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af92"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="af92"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><affiliation><nlm:aff id="af93"><addr-line>Department of Cancer Epidemiology and Prevention</addr-line>,<institution>M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine D" sort="Figueroa, Jonine D" uniqKey="Figueroa J" first="Jonine D." last="Figueroa">Jonine D. Figueroa</name><affiliation><nlm:aff id="af92"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="af94"><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation><nlm:aff id="af94"><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Verhoef, Senno" sort="Verhoef, Senno" uniqKey="Verhoef S" first="Senno" last="Verhoef">Senno Verhoef</name><affiliation><nlm:aff id="af94"><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Rutgers, Emiel J" sort="Rutgers, Emiel J" uniqKey="Rutgers E" first="Emiel J." last="Rutgers">Emiel J. Rutgers</name><affiliation><nlm:aff id="af94"><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="af95"><institution>University of Tübingen</institution>,<addr-line>Tübingen</addr-line>,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="af96"><institution>Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology</institution>,<addr-line>Stuttgart</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><affiliation><nlm:aff id="af97"><addr-line>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance</addr-line>,<institution>Institute of the Ruhr-University Bochum (IPA)</institution>,<addr-line>Bochum</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name><affiliation><nlm:aff id="af98"><addr-line>Department of Internal Medicine</addr-line>,<institution>Evangelische Kliniken Bonn GmbH, Johanniter Krankenhaus</institution>,<addr-line>Bonn</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff wicri:cut=" and" id="af44"><addr-line>Department of Laboratory Medicine and Pathology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name><affiliation><nlm:aff id="af101"><addr-line>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center</addr-line>,<institution>The Ohio State University</institution>,<addr-line>Columbus, OH</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name><affiliation><nlm:aff id="af102"><addr-line>Molecular Diagnostics Laboratory, INRASTES</addr-line>,<institution>National Centre for Scientific Research ‘Demokritos’</institution>,<addr-line>Athens</addr-line>,<country>Greece</country></nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation><nlm:aff wicri:cut=" and" id="af7"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af8"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="af11"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name><affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Human Cancer Genetics Programme</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Human Genotyping-CEGEN Unit</addr-line>,<institution>Spanish National Cancer Research Centre (CNIO)</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country></nlm:aff></affiliation><affiliation><nlm:aff id="af103"><institution>Biomedical Network on Rare Diseases (CIBERER)</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Malats, Nuria" sort="Malats, Nuria" uniqKey="Malats N" first="Núria" last="Malats">Núria Malats</name><affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Human Cancer Genetics Programme</addr-line></nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff wicri:cut=" and" id="af7"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af8"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24242184</idno><idno type="pmc">3943524</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943524</idno><idno type="RBID">PMC:3943524</idno><idno type="doi">10.1093/hmg/ddt581</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">001870</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001870</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46 450 cases and 42 461 controls from the breast cancer association consortium</title><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Human Cancer Genetics Programme</addr-line></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af3"><addr-line>Centre for Epidemiology and Biostatistics, School of Population Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af5"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Herranz, Jesus" sort="Herranz, Jesus" uniqKey="Herranz J" first="Jesús" last="Herranz">Jesús Herranz</name><affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Human Cancer Genetics Programme</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af6"><addr-line>Biostatistics Unit</addr-line>,<institution>IMDEA Food Institute</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff wicri:cut=" and" id="af7"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation><nlm:aff wicri:cut=" and" id="af7"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tyrer, Jonathan P" sort="Tyrer, Jonathan P" uniqKey="Tyrer J" first="Jonathan P." last="Tyrer">Jonathan P. Tyrer</name><affiliation><nlm:aff id="af8"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Zamora, M Pilar" sort="Zamora, M Pilar" uniqKey="Zamora M" first="M. Pilar" last="Zamora">M. Pilar Zamora</name><affiliation><nlm:aff id="af9"><addr-line>Servicio de Oncología Médica</addr-line>,<institution>Hospital Universitario La Paz</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Arias Perez, Jose Ignacio" sort="Arias Perez, Jose Ignacio" uniqKey="Arias Perez J" first="José Ignacio" last="Arias-Perez">José Ignacio Arias-Perez</name><affiliation><nlm:aff id="af10"><addr-line>Servicio de Cirugía General y Especialidades</addr-line>,<institution>Hospital Monte Naranco</institution>,<addr-line>Oviedo</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name><affiliation><nlm:aff id="af2"><addr-line>Human Genotyping-CEGEN Unit</addr-line>,<institution>Spanish National Cancer Research Centre (CNIO)</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Pita, Guillermo" sort="Pita, Guillermo" uniqKey="Pita G" first="Guillermo" last="Pita">Guillermo Pita</name><affiliation><nlm:aff id="af2"><addr-line>Human Genotyping-CEGEN Unit</addr-line>,<institution>Spanish National Cancer Research Centre (CNIO)</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Alonso, M Rosario" sort="Alonso, M Rosario" uniqKey="Alonso M" first="M. Rosario" last="Alonso">M. Rosario Alonso</name><affiliation><nlm:aff id="af2"><addr-line>Human Genotyping-CEGEN Unit</addr-line>,<institution>Spanish National Cancer Research Centre (CNIO)</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff wicri:cut=" and" id="af7"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name><affiliation><nlm:aff wicri:cut=" and" id="af7"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line></nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="af11"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Eriksson, Mikael" sort="Eriksson, Mikael" uniqKey="Eriksson M" first="Mikael" last="Eriksson">Mikael Eriksson</name><affiliation><nlm:aff id="af11"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name><affiliation><nlm:aff id="af11"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name><affiliation><nlm:aff id="af11"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation><nlm:aff id="af14"><addr-line>Human Genetics Division</addr-line>,<institution>Genome Institute of Singapore</institution>,<country>Singapore</country></nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="af15"><addr-line>Department of Epidemiology</addr-line>,<institution>University of California Irvine</institution>,<addr-line>Irvine, CA</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation><nlm:aff id="af16"><institution>Beckman Research Institute</institution>,<addr-line>City of Hope, Duarte, CA</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name><affiliation><nlm:aff id="af15"><addr-line>Department of Epidemiology</addr-line>,<institution>University of California Irvine</institution>,<addr-line>Irvine, CA</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Clarke, Christina A" sort="Clarke, Christina A" uniqKey="Clarke C" first="Christina A." last="Clarke">Christina A. Clarke</name><affiliation><nlm:aff id="af17"><institution>Cancer Prevention Institute of California</institution>,<addr-line>Fremont, CA</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff wicri:cut=" and" id="af3"><addr-line>Centre for Epidemiology and Biostatistics, School of Population Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dite, Gillian S" sort="Dite, Gillian S" uniqKey="Dite G" first="Gillian S." last="Dite">Gillian S. Dite</name><affiliation><nlm:aff wicri:cut=" and" id="af3"><addr-line>Centre for Epidemiology and Biostatistics, School of Population Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation><nlm:aff wicri:cut=" and" id="af3"><addr-line>Centre for Epidemiology and Biostatistics, School of Population Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="af4"><addr-line>Department of Pathology</addr-line>,<institution>University of Melbourne</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="af18"><institution>QIMR Berghofer Medical Research Institute</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation><nlm:aff id="af20"><addr-line>Division of Genetics and Epidemiology</addr-line>,<institution>The Institute of Cancer Research</institution>,<addr-line>Sutton</addr-line>,<country>UK</country></nlm:aff></affiliation><affiliation><nlm:aff id="af21"><addr-line>Division of Breast Cancer Research</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name><affiliation><nlm:aff id="af21"><addr-line>Division of Breast Cancer Research</addr-line></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af22"><addr-line>Breakthrough Breast Cancer Research Centre</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af23"><addr-line>Division of Molecular Pathology</addr-line>,<institution>The Institute of Cancer Research</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Orr, Nicholas" sort="Orr, Nicholas" uniqKey="Orr N" first="Nicholas" last="Orr">Nicholas Orr</name><affiliation><nlm:aff id="af21"><addr-line>Division of Breast Cancer Research</addr-line></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af22"><addr-line>Breakthrough Breast Cancer Research Centre</addr-line></nlm:aff></affiliation></author><author><name sortKey="Schoemaker, Minouk" sort="Schoemaker, Minouk" uniqKey="Schoemaker M" first="Minouk" last="Schoemaker">Minouk Schoemaker</name><affiliation><nlm:aff id="af20"><addr-line>Division of Genetics and Epidemiology</addr-line>,<institution>The Institute of Cancer Research</institution>,<addr-line>Sutton</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="af24"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="af24"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Jaworska Bieniek, Katarzyna" sort="Jaworska Bieniek, Katarzyna" uniqKey="Jaworska Bieniek K" first="Katarzyna" last="Jaworska-Bieniek">Katarzyna Jaworska-Bieniek</name><affiliation><nlm:aff id="af24"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country></nlm:aff></affiliation><affiliation><nlm:aff id="af25"><addr-line>Postgraduate School of Molecular Medicine</addr-line>,<institution>Warsaw Medical University</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><affiliation><nlm:aff id="af24"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="af26"><addr-line>Lunenfeld-Tanenbaum Research Institute</addr-line>,<institution>Mount Sinai Hospital</institution>,<addr-line>Toronto, Ontario</addr-line>,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="af27"><addr-line>Department of Molecular Genetics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name><affiliation><nlm:aff id="af26"><addr-line>Lunenfeld-Tanenbaum Research Institute</addr-line>,<institution>Mount Sinai Hospital</institution>,<addr-line>Toronto, Ontario</addr-line>,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af28"><addr-line>Division of Epidemiology, Dalla Lana School of Public Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="af30"><addr-line>Ontario Cancer Genetics Network</addr-line>,<institution>Lunenfeld-Tanenbaum Research Institute</institution>,<addr-line>Toronto, Ontario</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation><nlm:aff id="af29"><addr-line>Department of Laboratory Medicine and Pathobiology</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto, Ontario</addr-line>,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="af31"><addr-line>Laboratory Medicine Program</addr-line>,<institution>University Health Network</institution>,<addr-line>Toronto, Ontario</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="af32"><addr-line>Copenhagen General Population Study</addr-line></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af33"><addr-line>Department of Clinical Biochemistry</addr-line></nlm:aff></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation><nlm:aff id="af32"><addr-line>Copenhagen General Population Study</addr-line></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af33"><addr-line>Department of Clinical Biochemistry</addr-line></nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="af34"><addr-line>Department of Breast Surgery</addr-line>,<institution>Herlev University Hospital, University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="af35"><addr-line>Department of Obstetrics and Gynecology</addr-line>,<institution>University of Helsinki and Helsinki University Central Hospital</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A." last="Muranen">Taru A. Muranen</name><affiliation><nlm:aff id="af35"><addr-line>Department of Obstetrics and Gynecology</addr-line>,<institution>University of Helsinki and Helsinki University Central Hospital</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff wicri:cut=" and" id="af36"><addr-line>Department of Clinical Genetics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation><nlm:aff id="af37"><addr-line>Department of Oncology</addr-line>,<institution>Helsinki University Central Hospital</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="af38"><addr-line>Division of Cancer Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="af38"><addr-line>Division of Cancer Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Seibold, Petra" sort="Seibold, Petra" uniqKey="Seibold P" first="Petra" last="Seibold">Petra Seibold</name><affiliation><nlm:aff id="af38"><addr-line>Division of Cancer Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff wicri:cut=" and" id="af42"><addr-line>Department of Cancer Epidemiology/Clinical Cancer Registry</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af43"><addr-line>Institute for Medical Biometrics and Epidemiology</addr-line>,<institution>University Clinic Hamburg-Eppendorf</institution>,<addr-line>Hamburg</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><nlm:aff wicri:cut=" and" id="af44"><addr-line>Department of Laboratory Medicine and Pathology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><affiliation><nlm:aff id="af45"><addr-line>Department of Health Sciences Research</addr-line>,<institution>Mayo Clinic</institution>,<addr-line>Rochester, MN</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name><affiliation><nlm:aff id="af45"><addr-line>Department of Health Sciences Research</addr-line>,<institution>Mayo Clinic</institution>,<addr-line>Rochester, MN</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Purrington, Kristen" sort="Purrington, Kristen" uniqKey="Purrington K" first="Kristen" last="Purrington">Kristen Purrington</name><affiliation><nlm:aff id="af45"><addr-line>Department of Health Sciences Research</addr-line>,<institution>Mayo Clinic</institution>,<addr-line>Rochester, MN</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="af46"><addr-line>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation><nlm:aff id="af46"><addr-line>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu</addr-line></nlm:aff></affiliation></author><author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name><affiliation><nlm:aff wicri:cut=" and" id="af47"><addr-line>Department of Oncology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Grip, Mervi" sort="Grip, Mervi" uniqKey="Grip M" first="Mervi" last="Grip">Mervi Grip</name><affiliation><nlm:aff id="af48"><addr-line>Department of Surgery</addr-line>,<institution>Oulu University Hospital, University of Oulu</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="af8"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name><affiliation><nlm:aff id="af8"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation><nlm:aff id="af49"><addr-line>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018</addr-line>,<institution>Environmental Epidemiology of Cancer</institution>,<addr-line>Villejuif</addr-line>,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af50"><institution>University Paris-Sud</institution>,<addr-line>UMRS 1018, Villejuif</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation><nlm:aff id="af49"><addr-line>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018</addr-line>,<institution>Environmental Epidemiology of Cancer</institution>,<addr-line>Villejuif</addr-line>,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af50"><institution>University Paris-Sud</institution>,<addr-line>UMRS 1018, Villejuif</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Sanchez, Marie" sort="Sanchez, Marie" uniqKey="Sanchez M" first="Marie" last="Sanchez">Marie Sanchez</name><affiliation><nlm:aff id="af49"><addr-line>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018</addr-line>,<institution>Environmental Epidemiology of Cancer</institution>,<addr-line>Villejuif</addr-line>,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af50"><institution>University Paris-Sud</institution>,<addr-line>UMRS 1018, Villejuif</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Mulot, Claire" sort="Mulot, Claire" uniqKey="Mulot C" first="Claire" last="Mulot">Claire Mulot</name><affiliation><nlm:aff id="af51"><institution>Centre de Ressources Biologiques EPIGENETEC</institution>,<addr-line>Paris</addr-line>,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af52"><institution>Inserm (National Institute of Health and Medical Research)</institution>,<addr-line>U775, Paris</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="af39"><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af53"><institution>German Cancer Consortium (DKTK)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Dieffenbach, Aida Karina" sort="Dieffenbach, Aida Karina" uniqKey="Dieffenbach A" first="Aida Karina" last="Dieffenbach">Aida Karina Dieffenbach</name><affiliation><nlm:aff id="af39"><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af53"><institution>German Cancer Consortium (DKTK)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="af39"><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name><affiliation><nlm:aff id="af54"><institution>Saarland Cancer Registry</institution>,<addr-line>Saarbrücken</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff wicri:cut=" and" id="af12"><addr-line>Department of Molecular Medicine and Surgery</addr-line></nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation><nlm:aff id="af13"><addr-line>Department of Oncology - Pathology</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm</addr-line>,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name><affiliation><nlm:aff wicri:cut=" and" id="af55"><addr-line>Department of Medical Oncology, Family Cancer Clinic</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation><nlm:aff wicri:cut=" and" id="af55"><addr-line>Department of Medical Oncology, Family Cancer Clinic</addr-line></nlm:aff></affiliation></author><author><name sortKey="Collee, J Margriet" sort="Collee, J Margriet" uniqKey="Collee J" first="J. Margriet" last="Collée">J. Margriet Collée</name><affiliation><nlm:aff id="af56"><addr-line>Department of Clinical Genetics, Family Cancer Clinic</addr-line>,<institution>Erasmus University Medical Center</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Jager, Agnes" sort="Jager, Agnes" uniqKey="Jager A" first="Agnes" last="Jager">Agnes Jager</name><affiliation><nlm:aff wicri:cut=" and" id="af55"><addr-line>Department of Medical Oncology, Family Cancer Clinic</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="af57"><addr-line>CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology</addr-line>,<institution>University of Sheffield</institution>,<addr-line>Sheffield</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Brock, Ian W" sort="Brock, Ian W" uniqKey="Brock I" first="Ian W." last="Brock">Ian W. Brock</name><affiliation><nlm:aff id="af57"><addr-line>CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology</addr-line>,<institution>University of Sheffield</institution>,<addr-line>Sheffield</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Reed, Malcolm W R" sort="Reed, Malcolm W R" uniqKey="Reed M" first="Malcolm W. R." last="Reed">Malcolm W. R. Reed</name><affiliation><nlm:aff id="af57"><addr-line>CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology</addr-line>,<institution>University of Sheffield</institution>,<addr-line>Sheffield</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:aff id="af58"><addr-line>Department of Human Genetics</addr-line></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af59"><addr-line>Department of Pathology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tollenaar, Robert A E M" sort="Tollenaar, Robert A E M" uniqKey="Tollenaar R" first="Robert A. E. M." last="Tollenaar">Robert A. E. M. Tollenaar</name><affiliation><nlm:aff id="af60"><addr-line>Department of Surgical Oncology</addr-line>,<institution>Leiden University Medical Center</institution>,<addr-line>Leiden</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name><affiliation><nlm:aff wicri:cut=" and" id="af55"><addr-line>Department of Medical Oncology, Family Cancer Clinic</addr-line></nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="af61"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation><nlm:aff id="af61"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Schumacher, Fredrick" sort="Schumacher, Fredrick" uniqKey="Schumacher F" first="Fredrick" last="Schumacher">Fredrick Schumacher</name><affiliation><nlm:aff id="af61"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="af62"><institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="af63"><addr-line>Cancer Genomics Laboratory</addr-line>,<institution>Centre Hospitalier Universitaire de Quebec Research Center and Laval University</institution>,<addr-line>Quebec</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name><affiliation><nlm:aff id="af63"><addr-line>Cancer Genomics Laboratory</addr-line>,<institution>Centre Hospitalier Universitaire de Quebec Research Center and Laval University</institution>,<addr-line>Quebec</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name><affiliation><nlm:aff id="af63"><addr-line>Cancer Genomics Laboratory</addr-line>,<institution>Centre Hospitalier Universitaire de Quebec Research Center and Laval University</institution>,<addr-line>Quebec</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff wicri:cut=" and" id="af64"><addr-line>Department of Obstetrics and Gynaecology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name><affiliation><nlm:aff wicri:cut=" and" id="af64"><addr-line>Department of Obstetrics and Gynaecology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af65"><addr-line>Department of Radiation Oncology</addr-line>,<institution>Hannover Medical School</institution>,<addr-line>Hannover</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="af66"><addr-line>Molecular Genetics of Breast Cancer</addr-line>,<institution>Deutsches Krebsforschungszentrum (DKFZ)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Forsti, Asta" sort="Forsti, Asta" uniqKey="Forsti A" first="Asta" last="Försti">Asta Försti</name><affiliation><nlm:aff wicri:cut=" and" id="af40"><addr-line>Division of Molecular Genetic Epidemiology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af67"><addr-line>Center for Primary Health Care Research</addr-line>,<institution>Lund University</institution>,<addr-line>Malmö</addr-line>,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Rudiger, Thomas" sort="Rudiger, Thomas" uniqKey="Rudiger T" first="Thomas" last="Rüdiger">Thomas Rüdiger</name><affiliation><nlm:aff id="af68"><institution>Institute of Pathology, Städtisches Klinikum Karlsruhe</institution>,<addr-line>Karlsruhe</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Ulmer, Hans Ulrich" sort="Ulmer, Hans Ulrich" uniqKey="Ulmer H" first="Hans-Ulrich" last="Ulmer">Hans-Ulrich Ulmer</name><affiliation><nlm:aff id="af69"><institution>Frauenklinik der Stadtklinik Baden-Baden</institution>,<addr-line>Baden-Baden</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="af70"><addr-line>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen</addr-line>,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="af71"><addr-line>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology</addr-line>,<institution>University of California at Los Angeles</institution>,<addr-line>Los Angeles</addr-line><addr-line>, CA</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="H Berle, Lothar" sort="H Berle, Lothar" uniqKey="H Berle L" first="Lothar" last="H Berle">Lothar H Berle</name><affiliation><nlm:aff id="af70"><addr-line>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation><nlm:aff id="af72"><addr-line>Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany</addr-line></nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="af70"><addr-line>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff wicri:cut=" and" id="af22"><addr-line>Breakthrough Breast Cancer Research Centre</addr-line></nlm:aff></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation><nlm:aff wicri:cut=" and" id="af22"><addr-line>Breakthrough Breast Cancer Research Centre</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos Santos Silva">Isabel Dos Santos Silva</name><affiliation><nlm:aff id="af73"><institution>London School of Hygiene and Tropical Medicine</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="af73"><institution>London School of Hygiene and Tropical Medicine</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff wicri:cut=" and" id="af74"><addr-line>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="af76"><addr-line>IFOM</addr-line>,<institution>Fondazione Istituto FIRC di Oncologia Molecolare</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Peissel, Bernard" sort="Peissel, Bernard" uniqKey="Peissel B" first="Bernard" last="Peissel">Bernard Peissel</name><affiliation><nlm:aff id="af75"><addr-line>Unit of Medical Genetics, Department of Preventive and Predictive Medicine</addr-line>,<institution>Fondazione IRCCS Istituto Nazionale dei Tumori (INT)</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Mariani, Paolo" sort="Mariani, Paolo" uniqKey="Mariani P" first="Paolo" last="Mariani">Paolo Mariani</name><affiliation><nlm:aff id="af76"><addr-line>IFOM</addr-line>,<institution>Fondazione Istituto FIRC di Oncologia Molecolare</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff></affiliation><affiliation><nlm:aff id="af77"><institution>Cogentech Cancer Genetic Test Laboratory</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff wicri:cut=" and" id="af3"><addr-line>Centre for Epidemiology and Biostatistics, School of Population Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af5"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff wicri:cut=" and" id="af3"><addr-line>Centre for Epidemiology and Biostatistics, School of Population Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af5"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation><nlm:aff wicri:cut=" and" id="af3"><addr-line>Centre for Epidemiology and Biostatistics, School of Population Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af5"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor" sort="Sawyer, Elinor" uniqKey="Sawyer E" first="Elinor" last="Sawyer">Elinor Sawyer</name><affiliation><nlm:aff id="af78"><addr-line>Division of Cancer Studies</addr-line>,<institution>NIHR Comprehensive Biomedical Research Centre, Guy's & St. Thomas’ NHS Foundation Trust in Partnership with King's College London</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation><nlm:aff wicri:cut=" and" id="af79"><addr-line>Wellcome Trust Centre for Human Genetics</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af80"><addr-line>Oxford Biomedical Research Centre</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Kerin, Michael" sort="Kerin, Michael" uniqKey="Kerin M" first="Michael" last="Kerin">Michael Kerin</name><affiliation><nlm:aff id="af81"><addr-line>School of Medicine, Clinical Science Institute</addr-line>,<institution>National University of Ireland</institution>,<addr-line>Galway</addr-line>,<country>Ireland</country></nlm:aff></affiliation></author><author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name><affiliation><nlm:aff id="af81"><addr-line>School of Medicine, Clinical Science Institute</addr-line>,<institution>National University of Ireland</institution>,<addr-line>Galway</addr-line>,<country>Ireland</country></nlm:aff></affiliation></author><author><name sortKey="Marme, Federik" sort="Marme, Federik" uniqKey="Marme F" first="Federik" last="Marme">Federik Marme</name><affiliation><nlm:aff wicri:cut=" and" id="af82"><addr-line>Department of Obstetrics and Gynecology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af83"><addr-line>National Center for Tumor Diseases</addr-line>,<institution>University of Heidelberg</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="af41"><addr-line>Molecular Epidemiology Group</addr-line>,<institution>German Cancer Research Center (DKFZ)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af82"><addr-line>Department of Obstetrics and Gynecology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff wicri:cut=" and" id="af84"><addr-line>Department of Clinical Pathology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af86"><addr-line>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af87"><addr-line>Biocenter Kuopio</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name><affiliation><nlm:aff id="af85"><institution>Cancer Center, Kuopio University Hospital</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af86"><addr-line>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af87"><addr-line>Biocenter Kuopio</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff wicri:cut=" and" id="af84"><addr-line>Department of Clinical Pathology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af86"><addr-line>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af87"><addr-line>Biocenter Kuopio</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M." last="Hartikainen">Jaana M. Hartikainen</name><affiliation><nlm:aff wicri:cut=" and" id="af84"><addr-line>Department of Clinical Pathology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af86"><addr-line>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af87"><addr-line>Biocenter Kuopio</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="af88"><institution>Vesalius Research Center (VRC), VIB</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Yesilyurt, Betul T" sort="Yesilyurt, Betul T" uniqKey="Yesilyurt B" first="Betul T." last="Yesilyurt">Betul T. Yesilyurt</name><affiliation><nlm:aff id="af88"><institution>Vesalius Research Center (VRC), VIB</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Floris, Giuseppe" sort="Floris, Giuseppe" uniqKey="Floris G" first="Giuseppe" last="Floris">Giuseppe Floris</name><affiliation><nlm:aff id="af89"><addr-line>Multidisciplinary Breast Center</addr-line>,<institution>University Hospital Gasthuisberg</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Leunen, Karin" sort="Leunen, Karin" uniqKey="Leunen K" first="Karin" last="Leunen">Karin Leunen</name><affiliation><nlm:aff id="af89"><addr-line>Multidisciplinary Breast Center</addr-line>,<institution>University Hospital Gasthuisberg</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Aln S, Grethe Grenaker" sort="Aln S, Grethe Grenaker" uniqKey="Aln S G" first="Grethe Grenaker" last="Aln S">Grethe Grenaker Aln S</name><affiliation><nlm:aff id="af90"><addr-line>Department of Genetics</addr-line>,<institution>Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country></nlm:aff></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation><nlm:aff id="af90"><addr-line>Department of Genetics</addr-line>,<institution>Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country></nlm:aff></affiliation><affiliation><nlm:aff id="af91"><addr-line>Faculty of Medicine (Faculty Division Ahus)</addr-line>,<institution>UiO</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country></nlm:aff></affiliation></author><author><name sortKey="B Rresen Dale, Anne Lise" sort="B Rresen Dale, Anne Lise" uniqKey="B Rresen Dale A" first="Anne-Lise" last="B Rresen-Dale">Anne-Lise B Rresen-Dale</name><affiliation><nlm:aff id="af90"><addr-line>Department of Genetics</addr-line>,<institution>Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country></nlm:aff></affiliation><affiliation><nlm:aff id="af91"><addr-line>Faculty of Medicine (Faculty Division Ahus)</addr-line>,<institution>UiO</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country></nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation><nlm:aff id="af20"><addr-line>Division of Genetics and Epidemiology</addr-line>,<institution>The Institute of Cancer Research</institution>,<addr-line>Sutton</addr-line>,<country>UK</country></nlm:aff></affiliation><affiliation><nlm:aff id="af21"><addr-line>Division of Breast Cancer Research</addr-line></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af22"><addr-line>Breakthrough Breast Cancer Research Centre</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af92"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="af92"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><affiliation><nlm:aff id="af93"><addr-line>Department of Cancer Epidemiology and Prevention</addr-line>,<institution>M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine D" sort="Figueroa, Jonine D" uniqKey="Figueroa J" first="Jonine D." last="Figueroa">Jonine D. Figueroa</name><affiliation><nlm:aff id="af92"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="af94"><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation><nlm:aff id="af94"><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Verhoef, Senno" sort="Verhoef, Senno" uniqKey="Verhoef S" first="Senno" last="Verhoef">Senno Verhoef</name><affiliation><nlm:aff id="af94"><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Rutgers, Emiel J" sort="Rutgers, Emiel J" uniqKey="Rutgers E" first="Emiel J." last="Rutgers">Emiel J. Rutgers</name><affiliation><nlm:aff id="af94"><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="af95"><institution>University of Tübingen</institution>,<addr-line>Tübingen</addr-line>,<country>Germany</country></nlm:aff></affiliation><affiliation><nlm:aff id="af96"><institution>Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology</institution>,<addr-line>Stuttgart</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><affiliation><nlm:aff id="af97"><addr-line>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance</addr-line>,<institution>Institute of the Ruhr-University Bochum (IPA)</institution>,<addr-line>Bochum</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name><affiliation><nlm:aff id="af98"><addr-line>Department of Internal Medicine</addr-line>,<institution>Evangelische Kliniken Bonn GmbH, Johanniter Krankenhaus</institution>,<addr-line>Bonn</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff wicri:cut=" and" id="af44"><addr-line>Department of Laboratory Medicine and Pathology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name><affiliation><nlm:aff id="af101"><addr-line>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center</addr-line>,<institution>The Ohio State University</institution>,<addr-line>Columbus, OH</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name><affiliation><nlm:aff id="af102"><addr-line>Molecular Diagnostics Laboratory, INRASTES</addr-line>,<institution>National Centre for Scientific Research ‘Demokritos’</institution>,<addr-line>Athens</addr-line>,<country>Greece</country></nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation><nlm:aff wicri:cut=" and" id="af7"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af8"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="af11"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name><affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Human Cancer Genetics Programme</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Human Genotyping-CEGEN Unit</addr-line>,<institution>Spanish National Cancer Research Centre (CNIO)</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country></nlm:aff></affiliation><affiliation><nlm:aff id="af103"><institution>Biomedical Network on Rare Diseases (CIBERER)</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Malats, Nuria" sort="Malats, Nuria" uniqKey="Malats N" first="Núria" last="Malats">Núria Malats</name><affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Human Cancer Genetics Programme</addr-line></nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff wicri:cut=" and" id="af7"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af8"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff></affiliation></author></analytic><series><title level="j">Human Molecular Genetics</title><idno type="ISSN">0964-6906</idno><idno type="eISSN">1460-2083</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Part of the substantial unexplained familial aggregation of breast cancer may be due to interactions between common variants, but few studies have had adequate statistical power to detect interactions of realistic magnitude. We aimed to assess all two-way interactions in breast cancer susceptibility between 70 917 single nucleotide polymorphisms (SNPs) selected primarily based on prior evidence of a marginal effect. Thirty-eight international studies contributed data for 46 450 breast cancer cases and 42 461 controls of European origin as part of a multi-consortium project (COGS). First, SNPs were preselected based on evidence (<italic>P</italic> < 0.01) of a per-allele main effect, and all two-way combinations of those were evaluated by a per-allele (1 d.f.) test for interaction using logistic regression. Second, all 2.5 billion possible two-SNP combinations were evaluated using Boolean operation-based screening and testing, and SNP pairs with the strongest evidence of interaction (<italic>P</italic> < 10<sup>−4</sup>) were selected for more careful assessment by logistic regression. Under the first approach, 3277 SNPs were preselected, but an evaluation of all possible two-SNP combinations (1 d.f.) identified no interactions at <italic>P</italic> < 10<sup>−8</sup>. Results from the second analytic approach were consistent with those from the first (<italic>P</italic> > 10<sup>−10</sup>). In summary, we observed little evidence of two-way SNP interactions in breast cancer susceptibility, despite the large number of SNPs with potential marginal effects considered and the very large sample size. This finding may have important implications for risk prediction, simplifying the modelling required. Further comprehensive, large-scale genome-wide interaction studies may identify novel interacting loci if the inherent logistic and computational challenges can be overcome.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Hum Mol Genet</journal-id><journal-id journal-id-type="iso-abbrev">Hum. Mol. 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rid="af67">67</xref></contrib><contrib contrib-type="author"><name><surname>Rüdiger</surname><given-names>Thomas</given-names></name><xref ref-type="aff" rid="af68">68</xref></contrib><contrib contrib-type="author"><name><surname>Ulmer</surname><given-names>Hans-Ulrich</given-names></name><xref ref-type="aff" rid="af69">69</xref></contrib><contrib contrib-type="author"><name><surname>Fasching</surname><given-names>Peter A.</given-names></name><xref ref-type="aff" rid="af70">70</xref><xref ref-type="aff" rid="af71">71</xref></contrib><contrib contrib-type="author"><name><surname>Häberle</surname><given-names>Lothar</given-names></name><xref ref-type="aff" rid="af70">70</xref></contrib><contrib contrib-type="author"><name><surname>Ekici</surname><given-names>Arif B.</given-names></name><xref ref-type="aff" rid="af72">72</xref></contrib><contrib contrib-type="author"><name><surname>Beckmann</surname><given-names>Matthias W.</given-names></name><xref ref-type="aff" rid="af70">70</xref></contrib><contrib contrib-type="author"><name><surname>Fletcher</surname><given-names>Olivia</given-names></name><xref ref-type="aff" rid="af22">22</xref></contrib><contrib contrib-type="author"><name><surname>Johnson</surname><given-names>Nichola</given-names></name><xref ref-type="aff" rid="af22">22</xref></contrib><contrib contrib-type="author"><name><surname>dos Santos Silva</surname><given-names>Isabel</given-names></name><xref ref-type="aff" rid="af73">73</xref></contrib><contrib contrib-type="author"><name><surname>Peto</surname><given-names>Julian</given-names></name><xref ref-type="aff" rid="af73">73</xref></contrib><contrib contrib-type="author"><name><surname>Radice</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="af74">74</xref></contrib><contrib contrib-type="author"><name><surname>Peterlongo</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="af76">76</xref></contrib><contrib contrib-type="author"><name><surname>Peissel</surname><given-names>Bernard</given-names></name><xref ref-type="aff" rid="af75">75</xref></contrib><contrib contrib-type="author"><name><surname>Mariani</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="af76">76</xref><xref ref-type="aff" rid="af77">77</xref></contrib><contrib contrib-type="author"><name><surname>Giles</surname><given-names>Graham G.</given-names></name><xref ref-type="aff" rid="af3">3</xref><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Severi</surname><given-names>Gianluca</given-names></name><xref ref-type="aff" rid="af3">3</xref><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Baglietto</surname><given-names>Laura</given-names></name><xref ref-type="aff" rid="af3">3</xref><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Sawyer</surname><given-names>Elinor</given-names></name><xref ref-type="aff" rid="af78">78</xref></contrib><contrib contrib-type="author"><name><surname>Tomlinson</surname><given-names>Ian</given-names></name><xref ref-type="aff" rid="af79">79</xref><xref ref-type="aff" rid="af80">80</xref></contrib><contrib contrib-type="author"><name><surname>Kerin</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="af81">81</xref></contrib><contrib contrib-type="author"><name><surname>Miller</surname><given-names>Nicola</given-names></name><xref ref-type="aff" rid="af81">81</xref></contrib><contrib contrib-type="author"><name><surname>Marme</surname><given-names>Federik</given-names></name><xref ref-type="aff" rid="af82">82</xref><xref ref-type="aff" rid="af83">83</xref></contrib><contrib contrib-type="author"><name><surname>Burwinkel</surname><given-names>Barbara</given-names></name><xref ref-type="aff" rid="af41">41</xref><xref ref-type="aff" rid="af82">82</xref></contrib><contrib contrib-type="author"><name><surname>Mannermaa</surname><given-names>Arto</given-names></name><xref ref-type="aff" rid="af84">84</xref><xref ref-type="aff" rid="af86">86</xref><xref ref-type="aff" rid="af87">87</xref></contrib><contrib contrib-type="author"><name><surname>Kataja</surname><given-names>Vesa</given-names></name><xref ref-type="aff" rid="af85">85</xref><xref ref-type="aff" rid="af86">86</xref><xref ref-type="aff" rid="af87">87</xref></contrib><contrib contrib-type="author"><name><surname>Kosma</surname><given-names>Veli-Matti</given-names></name><xref ref-type="aff" rid="af84">84</xref><xref ref-type="aff" rid="af86">86</xref><xref ref-type="aff" rid="af87">87</xref></contrib><contrib contrib-type="author"><name><surname>Hartikainen</surname><given-names>Jaana M.</given-names></name><xref ref-type="aff" rid="af84">84</xref><xref ref-type="aff" rid="af86">86</xref><xref ref-type="aff" rid="af87">87</xref></contrib><contrib contrib-type="author"><name><surname>Lambrechts</surname><given-names>Diether</given-names></name><xref ref-type="aff" rid="af88">88</xref></contrib><contrib contrib-type="author"><name><surname>Yesilyurt</surname><given-names>Betul T.</given-names></name><xref ref-type="aff" rid="af88">88</xref></contrib><contrib contrib-type="author"><name><surname>Floris</surname><given-names>Giuseppe</given-names></name><xref ref-type="aff" rid="af89">89</xref></contrib><contrib contrib-type="author"><name><surname>Leunen</surname><given-names>Karin</given-names></name><xref ref-type="aff" rid="af89">89</xref></contrib><contrib contrib-type="author"><name><surname>Alnæs</surname><given-names>Grethe Grenaker</given-names></name><xref ref-type="aff" rid="af90">90</xref></contrib><contrib contrib-type="author"><name><surname>Kristensen</surname><given-names>Vessela</given-names></name><xref ref-type="aff" rid="af90">90</xref><xref ref-type="aff" rid="af91">91</xref></contrib><contrib contrib-type="author"><name><surname>Børresen-Dale</surname><given-names>Anne-Lise</given-names></name><xref ref-type="aff" rid="af90">90</xref><xref ref-type="aff" rid="af91">91</xref></contrib><contrib contrib-type="author"><name><surname>García-Closas</surname><given-names>Montserrat</given-names></name><xref ref-type="aff" rid="af20">20</xref><xref ref-type="aff" rid="af21">21</xref><xref ref-type="aff" rid="af22">22</xref><xref ref-type="aff" rid="af92">92</xref></contrib><contrib contrib-type="author"><name><surname>Chanock</surname><given-names>Stephen J.</given-names></name><xref ref-type="aff" rid="af92">92</xref></contrib><contrib contrib-type="author"><name><surname>Lissowska</surname><given-names>Jolanta</given-names></name><xref ref-type="aff" rid="af93">93</xref></contrib><contrib contrib-type="author"><name><surname>Figueroa</surname><given-names>Jonine D.</given-names></name><xref ref-type="aff" rid="af92">92</xref></contrib><contrib contrib-type="author"><name><surname>Schmidt</surname><given-names>Marjanka K.</given-names></name><xref ref-type="aff" rid="af94">94</xref></contrib><contrib contrib-type="author"><name><surname>Broeks</surname><given-names>Annegien</given-names></name><xref ref-type="aff" rid="af94">94</xref></contrib><contrib contrib-type="author"><name><surname>Verhoef</surname><given-names>Senno</given-names></name><xref ref-type="aff" rid="af94">94</xref></contrib><contrib contrib-type="author"><name><surname>Rutgers</surname><given-names>Emiel J.</given-names></name><xref ref-type="aff" rid="af94">94</xref></contrib><contrib contrib-type="author"><name><surname>Brauch</surname><given-names>Hiltrud</given-names></name><xref ref-type="aff" rid="af95">95</xref><xref ref-type="aff" rid="af96">96</xref></contrib><contrib contrib-type="author"><name><surname>Brüning</surname><given-names>Thomas</given-names></name><xref ref-type="aff" rid="af97">97</xref></contrib><contrib contrib-type="author"><name><surname>Ko</surname><given-names>Yon-Dschun</given-names></name><xref ref-type="aff" rid="af98">98</xref></contrib><contrib contrib-type="author"><collab>The GENICA Network</collab><xref ref-type="aff" rid="af66">66</xref><xref ref-type="aff" rid="af95">95</xref><xref ref-type="aff" rid="af96">96</xref><xref ref-type="aff" rid="af97">97</xref><xref ref-type="aff" rid="af98">98</xref><xref ref-type="aff" rid="af99">99</xref><xref ref-type="aff" rid="af100">100</xref></contrib><contrib contrib-type="author"><name><surname>Couch</surname><given-names>Fergus J.</given-names></name><xref ref-type="aff" rid="af44">44</xref></contrib><contrib contrib-type="author"><name><surname>Toland</surname><given-names>Amanda E.</given-names></name><xref ref-type="aff" rid="af101">101</xref></contrib><contrib contrib-type="author"><collab>The TNBCC</collab><xref ref-type="aff" rid="af44">44</xref></contrib><contrib contrib-type="author"><name><surname>Yannoukakos</surname><given-names>Drakoulis</given-names></name><xref ref-type="aff" rid="af102">102</xref></contrib><contrib contrib-type="author"><name><surname>Pharoah</surname><given-names>Paul D.P.</given-names></name><xref ref-type="aff" rid="af7">7</xref><xref ref-type="aff" rid="af8">8</xref></contrib><contrib contrib-type="author"><name><surname>Hall</surname><given-names>Per</given-names></name><xref ref-type="aff" rid="af11">11</xref></contrib><contrib contrib-type="author"><name><surname>Benítez</surname><given-names>Javier</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref><xref ref-type="aff" rid="af103">103</xref></contrib><contrib contrib-type="author"><name><surname>Malats</surname><given-names>Núria</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas F.</given-names></name><xref ref-type="aff" rid="af7">7</xref><xref ref-type="aff" rid="af8">8</xref></contrib></contrib-group><aff id="af1"><label>1</label><addr-line>Human Cancer Genetics Programme</addr-line> and</aff><aff id="af2"><label>2</label><addr-line>Human Genotyping-CEGEN Unit</addr-line>,<institution>Spanish National Cancer Research Centre (CNIO)</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country></aff><aff id="af3"><label>3</label><addr-line>Centre for Epidemiology and Biostatistics, School of Population Health</addr-line> and</aff><aff id="af4"><label>4</label><addr-line>Department of Pathology</addr-line>,<institution>University of Melbourne</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country></aff><aff id="af5"><label>5</label><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country></aff><aff id="af6"><label>6</label><addr-line>Biostatistics Unit</addr-line>,<institution>IMDEA Food Institute</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country></aff><aff id="af7"><label>7</label><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line> and</aff><aff id="af8"><label>8</label><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></aff><aff id="af9"><label>9</label><addr-line>Servicio de Oncología Médica</addr-line>,<institution>Hospital Universitario La Paz</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country></aff><aff id="af10"><label>10</label><addr-line>Servicio de Cirugía General y Especialidades</addr-line>,<institution>Hospital Monte Naranco</institution>,<addr-line>Oviedo</addr-line>,<country>Spain</country></aff><aff id="af11"><label>11</label><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line></aff><aff id="af12"><label>12</label><addr-line>Department of Molecular Medicine and Surgery</addr-line> and</aff><aff id="af13"><label>13</label><addr-line>Department of Oncology - Pathology</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm</addr-line>,<country>Sweden</country></aff><aff id="af14"><label>14</label><addr-line>Human Genetics Division</addr-line>,<institution>Genome Institute of Singapore</institution>,<country>Singapore</country></aff><aff id="af15"><label>15</label><addr-line>Department of Epidemiology</addr-line>,<institution>University of California Irvine</institution>,<addr-line>Irvine, CA</addr-line>,<country>USA</country></aff><aff id="af16"><label>16</label><institution>Beckman Research Institute</institution>,<addr-line>City of Hope, Duarte, CA</addr-line>,<country>USA</country></aff><aff id="af17"><label>17</label><institution>Cancer Prevention Institute of California</institution>,<addr-line>Fremont, CA</addr-line>,<country>USA</country></aff><aff id="af18"><label>18</label><institution>QIMR Berghofer Medical Research Institute</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country></aff><aff id="af19"><label>19</label><institution>Peter MacCallum Cancer Centre</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country></aff><aff id="af20"><label>20</label><addr-line>Division of Genetics and Epidemiology</addr-line>,<institution>The Institute of Cancer Research</institution>,<addr-line>Sutton</addr-line>,<country>UK</country></aff><aff id="af21"><label>21</label><addr-line>Division of Breast Cancer Research</addr-line></aff><aff id="af22"><label>22</label><addr-line>Breakthrough Breast Cancer Research Centre</addr-line> and</aff><aff id="af23"><label>23</label><addr-line>Division of Molecular Pathology</addr-line>,<institution>The Institute of Cancer Research</institution>,<addr-line>London</addr-line>,<country>UK</country></aff><aff id="af24"><label>24</label><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country></aff><aff id="af25"><label>25</label><addr-line>Postgraduate School of Molecular Medicine</addr-line>,<institution>Warsaw Medical University</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country></aff><aff id="af26"><label>26</label><addr-line>Lunenfeld-Tanenbaum Research Institute</addr-line>,<institution>Mount Sinai Hospital</institution>,<addr-line>Toronto, Ontario</addr-line>,<country>Canada</country></aff><aff id="af27"><label>27</label><addr-line>Department of Molecular Genetics</addr-line></aff><aff id="af28"><label>28</label><addr-line>Division of Epidemiology, Dalla Lana School of Public Health</addr-line> and</aff><aff id="af29"><label>29</label><addr-line>Department of Laboratory Medicine and Pathobiology</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto, Ontario</addr-line>,<country>Canada</country></aff><aff id="af30"><label>30</label><addr-line>Ontario Cancer Genetics Network</addr-line>,<institution>Lunenfeld-Tanenbaum Research Institute</institution>,<addr-line>Toronto, Ontario</addr-line>,<country>Canada</country></aff><aff id="af31"><label>31</label><addr-line>Laboratory Medicine Program</addr-line>,<institution>University Health Network</institution>,<addr-line>Toronto, Ontario</addr-line>,<country>Canada</country></aff><aff id="af32"><label>32</label><addr-line>Copenhagen General Population Study</addr-line></aff><aff id="af33"><label>33</label><addr-line>Department of Clinical Biochemistry</addr-line> and</aff><aff id="af34"><label>34</label><addr-line>Department of Breast Surgery</addr-line>,<institution>Herlev University Hospital, University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country></aff><aff id="af35"><label>35</label><addr-line>Department of Obstetrics and Gynecology</addr-line>,<institution>University of Helsinki and Helsinki University Central Hospital</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country></aff><aff id="af36"><label>36</label><addr-line>Department of Clinical Genetics</addr-line> and</aff><aff id="af37"><label>37</label><addr-line>Department of Oncology</addr-line>,<institution>Helsinki University Central Hospital</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country></aff><aff id="af38"><label>38</label><addr-line>Division of Cancer Epidemiology</addr-line></aff><aff id="af39"><label>39</label><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line></aff><aff id="af40"><label>40</label><addr-line>Division of Molecular Genetic Epidemiology</addr-line> and</aff><aff id="af41"><label>41</label><addr-line>Molecular Epidemiology Group</addr-line>,<institution>German Cancer Research Center (DKFZ)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country></aff><aff id="af42"><label>42</label><addr-line>Department of Cancer Epidemiology/Clinical Cancer Registry</addr-line> and</aff><aff id="af43"><label>43</label><addr-line>Institute for Medical Biometrics and Epidemiology</addr-line>,<institution>University Clinic Hamburg-Eppendorf</institution>,<addr-line>Hamburg</addr-line>,<country>Germany</country></aff><aff id="af44"><label>44</label><addr-line>Department of Laboratory Medicine and Pathology</addr-line> and</aff><aff id="af45"><label>45</label><addr-line>Department of Health Sciences Research</addr-line>,<institution>Mayo Clinic</institution>,<addr-line>Rochester, MN</addr-line>,<country>USA</country></aff><aff id="af46"><label>46</label><addr-line>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu</addr-line></aff><aff id="af47"><label>47</label><addr-line>Department of Oncology</addr-line> and</aff><aff id="af48"><label>48</label><addr-line>Department of Surgery</addr-line>,<institution>Oulu University Hospital, University of Oulu</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country></aff><aff id="af49"><label>49</label><addr-line>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018</addr-line>,<institution>Environmental Epidemiology of Cancer</institution>,<addr-line>Villejuif</addr-line>,<country>France</country></aff><aff id="af50"><label>50</label><institution>University Paris-Sud</institution>,<addr-line>UMRS 1018, Villejuif</addr-line>,<country>France</country></aff><aff id="af51"><label>51</label><institution>Centre de Ressources Biologiques EPIGENETEC</institution>,<addr-line>Paris</addr-line>,<country>France</country></aff><aff id="af52"><label>52</label><institution>Inserm (National Institute of Health and Medical Research)</institution>,<addr-line>U775, Paris</addr-line>,<country>France</country></aff><aff id="af53"><label>53</label><institution>German Cancer Consortium (DKTK)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country></aff><aff id="af54"><label>54</label><institution>Saarland Cancer Registry</institution>,<addr-line>Saarbrücken</addr-line>,<country>Germany</country></aff><aff id="af55"><label>55</label><addr-line>Department of Medical Oncology, Family Cancer Clinic</addr-line> and</aff><aff id="af56"><label>56</label><addr-line>Department of Clinical Genetics, Family Cancer Clinic</addr-line>,<institution>Erasmus University Medical Center</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country></aff><aff id="af57"><label>57</label><addr-line>CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology</addr-line>,<institution>University of Sheffield</institution>,<addr-line>Sheffield</addr-line>,<country>UK</country></aff><aff id="af58"><label>58</label><addr-line>Department of Human Genetics</addr-line></aff><aff id="af59"><label>59</label><addr-line>Department of Pathology</addr-line> and</aff><aff id="af60"><label>60</label><addr-line>Department of Surgical Oncology</addr-line>,<institution>Leiden University Medical Center</institution>,<addr-line>Leiden</addr-line>,<country>The Netherlands</country></aff><aff id="af61"><label>61</label><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country></aff><aff id="af62"><label>62</label><institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI</addr-line>,<country>USA</country></aff><aff id="af63"><label>63</label><addr-line>Cancer Genomics Laboratory</addr-line>,<institution>Centre Hospitalier Universitaire de Quebec Research Center and Laval University</institution>,<addr-line>Quebec</addr-line>,<country>Canada</country></aff><aff id="af64"><label>64</label><addr-line>Department of Obstetrics and Gynaecology</addr-line> and</aff><aff id="af65"><label>65</label><addr-line>Department of Radiation Oncology</addr-line>,<institution>Hannover Medical School</institution>,<addr-line>Hannover</addr-line>,<country>Germany</country></aff><aff id="af66"><label>66</label><addr-line>Molecular Genetics of Breast Cancer</addr-line>,<institution>Deutsches Krebsforschungszentrum (DKFZ)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country></aff><aff id="af67"><label>67</label><addr-line>Center for Primary Health Care Research</addr-line>,<institution>Lund University</institution>,<addr-line>Malmö</addr-line>,<country>Sweden</country></aff><aff id="af68"><label>68</label><institution>Institute of Pathology, Städtisches Klinikum Karlsruhe</institution>,<addr-line>Karlsruhe</addr-line>,<country>Germany</country></aff><aff id="af69"><label>69</label><institution>Frauenklinik der Stadtklinik Baden-Baden</institution>,<addr-line>Baden-Baden</addr-line>,<country>Germany</country></aff><aff id="af70"><label>70</label><addr-line>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen</addr-line>,<country>Germany</country></aff><aff id="af71"><label>71</label><addr-line>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology</addr-line>,<institution>University of California at Los Angeles</institution>,<addr-line>Los Angeles</addr-line><addr-line>, CA</addr-line>,<country>USA</country></aff><aff id="af72"><label>72</label><addr-line>Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany</addr-line></aff><aff id="af73"><label>73</label><institution>London School of Hygiene and Tropical Medicine</institution>,<addr-line>London</addr-line>,<country>UK</country></aff><aff id="af74"><label>74</label><addr-line>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine</addr-line> and</aff><aff id="af75"><label>75</label><addr-line>Unit of Medical Genetics, Department of Preventive and Predictive Medicine</addr-line>,<institution>Fondazione IRCCS Istituto Nazionale dei Tumori (INT)</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></aff><aff id="af76"><label>76</label><addr-line>IFOM</addr-line>,<institution>Fondazione Istituto FIRC di Oncologia Molecolare</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></aff><aff id="af77"><label>77</label><institution>Cogentech Cancer Genetic Test Laboratory</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></aff><aff id="af78"><label>78</label><addr-line>Division of Cancer Studies</addr-line>,<institution>NIHR Comprehensive Biomedical Research Centre, Guy's & St. Thomas’ NHS Foundation Trust in Partnership with King's College London</institution>,<addr-line>London</addr-line>,<country>UK</country></aff><aff id="af79"><label>79</label><addr-line>Wellcome Trust Centre for Human Genetics</addr-line> and</aff><aff id="af80"><label>80</label><addr-line>Oxford Biomedical Research Centre</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country></aff><aff id="af81"><label>81</label><addr-line>School of Medicine, Clinical Science Institute</addr-line>,<institution>National University of Ireland</institution>,<addr-line>Galway</addr-line>,<country>Ireland</country></aff><aff id="af82"><label>82</label><addr-line>Department of Obstetrics and Gynecology</addr-line> and</aff><aff id="af83"><label>83</label><addr-line>National Center for Tumor Diseases</addr-line>,<institution>University of Heidelberg</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country></aff><aff id="af84"><label>84</label><addr-line>Department of Clinical Pathology</addr-line> and</aff><aff id="af85"><label>85</label><institution>Cancer Center, Kuopio University Hospital</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country></aff><aff id="af86"><label>86</label><addr-line>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine</addr-line> and</aff><aff id="af87"><label>87</label><addr-line>Biocenter Kuopio</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country></aff><aff id="af88"><label>88</label><institution>Vesalius Research Center (VRC), VIB</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country></aff><aff id="af89"><label>89</label><addr-line>Multidisciplinary Breast Center</addr-line>,<institution>University Hospital Gasthuisberg</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country></aff><aff id="af90"><label>90</label><addr-line>Department of Genetics</addr-line>,<institution>Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country></aff><aff id="af91"><label>91</label><addr-line>Faculty of Medicine (Faculty Division Ahus)</addr-line>,<institution>UiO</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country></aff><aff id="af92"><label>92</label><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD</addr-line>,<country>USA</country></aff><aff id="af93"><label>93</label><addr-line>Department of Cancer Epidemiology and Prevention</addr-line>,<institution>M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country></aff><aff id="af94"><label>94</label><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country></aff><aff id="af95"><label>95</label><institution>University of Tübingen</institution>,<addr-line>Tübingen</addr-line>,<country>Germany</country></aff><aff id="af96"><label>96</label><institution>Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology</institution>,<addr-line>Stuttgart</addr-line>,<country>Germany</country></aff><aff id="af97"><label>97</label><addr-line>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance</addr-line>,<institution>Institute of the Ruhr-University Bochum (IPA)</institution>,<addr-line>Bochum</addr-line>,<country>Germany</country></aff><aff id="af98"><label>98</label><addr-line>Department of Internal Medicine</addr-line>,<institution>Evangelische Kliniken Bonn GmbH, Johanniter Krankenhaus</institution>,<addr-line>Bonn</addr-line>,<country>Germany</country></aff><aff id="af99"><label>99</label><addr-line>Institute for Occupational Medicine and Maritime Medicine</addr-line>,<institution>University Medical Center Hamburg-Eppendorf</institution>,<addr-line>Hamburg</addr-line>,<country>Germany</country></aff><aff id="af100"><label>100</label><addr-line>Institute of Pathology</addr-line>,<institution>Medical Faculty of the University of Bonn</institution>,<addr-line>Bonn</addr-line>,<country>Germany</country></aff><aff id="af101"><label>101</label><addr-line>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center</addr-line>,<institution>The Ohio State University</institution>,<addr-line>Columbus, OH</addr-line>,<country>USA</country></aff><aff id="af102"><label>102</label><addr-line>Molecular Diagnostics Laboratory, INRASTES</addr-line>,<institution>National Centre for Scientific Research ‘Demokritos’</institution>,<addr-line>Athens</addr-line>,<country>Greece</country></aff><aff id="af103"><label>103</label><institution>Biomedical Network on Rare Diseases (CIBERER)</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country></aff><author-notes><corresp id="cor1"><label>*</label>To whom correspondence should be addressed at: Cancer Epidemiology Centre, Cancer Council Victoria, 100 Drummond Street, Carlton 3053, Australia. Tel: 61 396355412; Fax: 61 396355330; Email: <email>roger.milne@cancervic.org.au</email></corresp></author-notes><pub-date pub-type="ppub"><day>1</day><month>4</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>15</day><month>11</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>4</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 12 months and
0 days and was based on the
<volume>23</volume><issue>7</issue><fpage>1934</fpage><lpage>1946</lpage><history><date date-type="received"><day>5</day><month>8</month><year>2013</year></date><date date-type="rev-recd"><day>28</day><month>10</month><year>2013</year></date><date date-type="accepted"><day>12</day><month>11</month><year>2013</year></date></history><permissions><copyright-statement>© The Author 2013. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com</copyright-statement><copyright-year>2013</copyright-year></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="ddt581.pdf"></self-uri><abstract><p>Part of the substantial unexplained familial aggregation of breast cancer may be due to interactions between common variants, but few studies have had adequate statistical power to detect interactions of realistic magnitude. We aimed to assess all two-way interactions in breast cancer susceptibility between 70 917 single nucleotide polymorphisms (SNPs) selected primarily based on prior evidence of a marginal effect. Thirty-eight international studies contributed data for 46 450 breast cancer cases and 42 461 controls of European origin as part of a multi-consortium project (COGS). First, SNPs were preselected based on evidence (<italic>P</italic> < 0.01) of a per-allele main effect, and all two-way combinations of those were evaluated by a per-allele (1 d.f.) test for interaction using logistic regression. Second, all 2.5 billion possible two-SNP combinations were evaluated using Boolean operation-based screening and testing, and SNP pairs with the strongest evidence of interaction (<italic>P</italic> < 10<sup>−4</sup>) were selected for more careful assessment by logistic regression. Under the first approach, 3277 SNPs were preselected, but an evaluation of all possible two-SNP combinations (1 d.f.) identified no interactions at <italic>P</italic> < 10<sup>−8</sup>. Results from the second analytic approach were consistent with those from the first (<italic>P</italic> > 10<sup>−10</sup>). In summary, we observed little evidence of two-way SNP interactions in breast cancer susceptibility, despite the large number of SNPs with potential marginal effects considered and the very large sample size. This finding may have important implications for risk prediction, simplifying the modelling required. Further comprehensive, large-scale genome-wide interaction studies may identify novel interacting loci if the inherent logistic and computational challenges can be overcome.</p></abstract><counts><page-count count="13"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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