AustralieFrV1, Pmc, Corpus, bibRecord, 001823

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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of serial infusions of reconstituted high-density lipoprotein (CER-001) on coronary atherosclerosis: rationale and design of the CARAT study</title>
<author><name sortKey="Andrews, Jordan" sort="Andrews, Jordan" uniqKey="Andrews J" first="Jordan" last="Andrews">Jordan Andrews</name>
<affiliation><nlm:aff id="aff1">South Australian Health and Medical Research Institute, University of Adelaide, Adelaide,<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Janssan, Alex" sort="Janssan, Alex" uniqKey="Janssan A" first="Alex" last="Janssan">Alex Janssan</name>
<affiliation><nlm:aff id="aff1">South Australian Health and Medical Research Institute, University of Adelaide, Adelaide,<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nguyen, Tracy" sort="Nguyen, Tracy" uniqKey="Nguyen T" first="Tracy" last="Nguyen">Tracy Nguyen</name>
<affiliation><nlm:aff id="aff1">South Australian Health and Medical Research Institute, University of Adelaide, Adelaide,<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pisaniello, Anthony D" sort="Pisaniello, Anthony D" uniqKey="Pisaniello A" first="Anthony D." last="Pisaniello">Anthony D. Pisaniello</name>
<affiliation><nlm:aff id="aff1">South Australian Health and Medical Research Institute, University of Adelaide, Adelaide,<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Scherer, Daniel J" sort="Scherer, Daniel J" uniqKey="Scherer D" first="Daniel J." last="Scherer">Daniel J. Scherer</name>
<affiliation><nlm:aff id="aff1">South Australian Health and Medical Research Institute, University of Adelaide, Adelaide,<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kastelein, John J P" sort="Kastelein, John J P" uniqKey="Kastelein J" first="John J. P." last="Kastelein">John J. P. Kastelein</name>
<affiliation><nlm:aff id="aff2">Academic Medical Center, University of Amsterdam, Amsterdam,<country>The Netherlands</country>
;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Merkely, Bela" sort="Merkely, Bela" uniqKey="Merkely B" first="Bela" last="Merkely">Bela Merkely</name>
<affiliation><nlm:aff id="aff3">Heart and Vascular Center, Semmelweis University, Budapest,<country>Hungary</country>
;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nissen, Steven E" sort="Nissen, Steven E" uniqKey="Nissen S" first="Steven E." last="Nissen">Steven E. Nissen</name>
<affiliation><nlm:aff id="aff4">Cleveland Clinic, Cleveland, Ohio,<country>USA</country>
;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ray, Kausik" sort="Ray, Kausik" uniqKey="Ray K" first="Kausik" last="Ray">Kausik Ray</name>
<affiliation><nlm:aff id="aff5">School of Public Health, Imperial College London, London,<country>UK</country>
;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schwartz, Gregory G" sort="Schwartz, Gregory G" uniqKey="Schwartz G" first="Gregory G." last="Schwartz">Gregory G. Schwartz</name>
<affiliation><nlm:aff id="aff6">University of Colorado School of Medicine, Denver, CO,<country>USA</country>
;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Worthley, Stephen G" sort="Worthley, Stephen G" uniqKey="Worthley S" first="Stephen G." last="Worthley">Stephen G. Worthley</name>
<affiliation><nlm:aff id="aff1">South Australian Health and Medical Research Institute, University of Adelaide, Adelaide,<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Keyserling, Connie" sort="Keyserling, Connie" uniqKey="Keyserling C" first="Connie" last="Keyserling">Connie Keyserling</name>
<affiliation><nlm:aff id="aff7">Cerenis Pharmaceuticals, Toulouse,<country>France</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dasseux, Jean Louis" sort="Dasseux, Jean Louis" uniqKey="Dasseux J" first="Jean-Louis" last="Dasseux">Jean-Louis Dasseux</name>
<affiliation><nlm:aff id="aff7">Cerenis Pharmaceuticals, Toulouse,<country>France</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Butters, Julie" sort="Butters, Julie" uniqKey="Butters J" first="Julie" last="Butters">Julie Butters</name>
<affiliation><nlm:aff id="aff1">South Australian Health and Medical Research Institute, University of Adelaide, Adelaide,<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Girardi, Jacinta" sort="Girardi, Jacinta" uniqKey="Girardi J" first="Jacinta" last="Girardi">Jacinta Girardi</name>
<affiliation><nlm:aff id="aff1">South Australian Health and Medical Research Institute, University of Adelaide, Adelaide,<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Miller, Rosemary" sort="Miller, Rosemary" uniqKey="Miller R" first="Rosemary" last="Miller">Rosemary Miller</name>
<affiliation><nlm:aff id="aff1">South Australian Health and Medical Research Institute, University of Adelaide, Adelaide,<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nicholls, Stephen J" sort="Nicholls, Stephen J" uniqKey="Nicholls S" first="Stephen J." last="Nicholls">Stephen J. Nicholls</name>
<affiliation><nlm:aff id="aff1">South Australian Health and Medical Research Institute, University of Adelaide, Adelaide,<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">28164012</idno>
<idno type="pmc">5253449</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253449</idno>
<idno type="RBID">PMC:5253449</idno>
<idno type="doi">10.21037/cdt.2017.01.01</idno>
<date when="2017">2017</date>
<idno type="wicri:Area/Pmc/Corpus">001823</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001823</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effect of serial infusions of reconstituted high-density lipoprotein (CER-001) on coronary atherosclerosis: rationale and design of the CARAT study</title>
<author><name sortKey="Andrews, Jordan" sort="Andrews, Jordan" uniqKey="Andrews J" first="Jordan" last="Andrews">Jordan Andrews</name>
<affiliation><nlm:aff id="aff1">South Australian Health and Medical Research Institute, University of Adelaide, Adelaide,<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Janssan, Alex" sort="Janssan, Alex" uniqKey="Janssan A" first="Alex" last="Janssan">Alex Janssan</name>
<affiliation><nlm:aff id="aff1">South Australian Health and Medical Research Institute, University of Adelaide, Adelaide,<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nguyen, Tracy" sort="Nguyen, Tracy" uniqKey="Nguyen T" first="Tracy" last="Nguyen">Tracy Nguyen</name>
<affiliation><nlm:aff id="aff1">South Australian Health and Medical Research Institute, University of Adelaide, Adelaide,<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pisaniello, Anthony D" sort="Pisaniello, Anthony D" uniqKey="Pisaniello A" first="Anthony D." last="Pisaniello">Anthony D. Pisaniello</name>
<affiliation><nlm:aff id="aff1">South Australian Health and Medical Research Institute, University of Adelaide, Adelaide,<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Scherer, Daniel J" sort="Scherer, Daniel J" uniqKey="Scherer D" first="Daniel J." last="Scherer">Daniel J. Scherer</name>
<affiliation><nlm:aff id="aff1">South Australian Health and Medical Research Institute, University of Adelaide, Adelaide,<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kastelein, John J P" sort="Kastelein, John J P" uniqKey="Kastelein J" first="John J. P." last="Kastelein">John J. P. Kastelein</name>
<affiliation><nlm:aff id="aff2">Academic Medical Center, University of Amsterdam, Amsterdam,<country>The Netherlands</country>
;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Merkely, Bela" sort="Merkely, Bela" uniqKey="Merkely B" first="Bela" last="Merkely">Bela Merkely</name>
<affiliation><nlm:aff id="aff3">Heart and Vascular Center, Semmelweis University, Budapest,<country>Hungary</country>
;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nissen, Steven E" sort="Nissen, Steven E" uniqKey="Nissen S" first="Steven E." last="Nissen">Steven E. Nissen</name>
<affiliation><nlm:aff id="aff4">Cleveland Clinic, Cleveland, Ohio,<country>USA</country>
;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ray, Kausik" sort="Ray, Kausik" uniqKey="Ray K" first="Kausik" last="Ray">Kausik Ray</name>
<affiliation><nlm:aff id="aff5">School of Public Health, Imperial College London, London,<country>UK</country>
;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schwartz, Gregory G" sort="Schwartz, Gregory G" uniqKey="Schwartz G" first="Gregory G." last="Schwartz">Gregory G. Schwartz</name>
<affiliation><nlm:aff id="aff6">University of Colorado School of Medicine, Denver, CO,<country>USA</country>
;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Worthley, Stephen G" sort="Worthley, Stephen G" uniqKey="Worthley S" first="Stephen G." last="Worthley">Stephen G. Worthley</name>
<affiliation><nlm:aff id="aff1">South Australian Health and Medical Research Institute, University of Adelaide, Adelaide,<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Keyserling, Connie" sort="Keyserling, Connie" uniqKey="Keyserling C" first="Connie" last="Keyserling">Connie Keyserling</name>
<affiliation><nlm:aff id="aff7">Cerenis Pharmaceuticals, Toulouse,<country>France</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dasseux, Jean Louis" sort="Dasseux, Jean Louis" uniqKey="Dasseux J" first="Jean-Louis" last="Dasseux">Jean-Louis Dasseux</name>
<affiliation><nlm:aff id="aff7">Cerenis Pharmaceuticals, Toulouse,<country>France</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Butters, Julie" sort="Butters, Julie" uniqKey="Butters J" first="Julie" last="Butters">Julie Butters</name>
<affiliation><nlm:aff id="aff1">South Australian Health and Medical Research Institute, University of Adelaide, Adelaide,<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Girardi, Jacinta" sort="Girardi, Jacinta" uniqKey="Girardi J" first="Jacinta" last="Girardi">Jacinta Girardi</name>
<affiliation><nlm:aff id="aff1">South Australian Health and Medical Research Institute, University of Adelaide, Adelaide,<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Miller, Rosemary" sort="Miller, Rosemary" uniqKey="Miller R" first="Rosemary" last="Miller">Rosemary Miller</name>
<affiliation><nlm:aff id="aff1">South Australian Health and Medical Research Institute, University of Adelaide, Adelaide,<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nicholls, Stephen J" sort="Nicholls, Stephen J" uniqKey="Nicholls S" first="Stephen J." last="Nicholls">Stephen J. Nicholls</name>
<affiliation><nlm:aff id="aff1">South Australian Health and Medical Research Institute, University of Adelaide, Adelaide,<country>Australia</country>
</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Cardiovascular Diagnosis and Therapy</title>
<idno type="ISSN">2223-3652</idno>
<idno type="eISSN">2223-3660</idno>
<imprint><date when="2017">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>High-density lipoprotein (HDL) is believed to have atheroprotective properties, but an effective HDL-based therapy remains elusive. Early studies have suggested that infusion of reconstituted HDL promotes reverse cholesterol transport and vascular reactivity. The CER-001 Atherosclerosis Regression Acute Coronary Syndrome Trial (CARAT) is investigating the impact of infusing an engineered pre-beta HDL mimetic containing sphingomyelin (SM) and dipalmitoyl phosphatidlyglycerol (CER-001) on coronary atheroma volume in patients with a recent acute coronary syndrome (ACS).</p>
</sec>
<sec><title>Methods</title>
<p>The CARAT is a phase 2, multicenter trial in which 292 patients with an ACS undergoing intracoronary ultrasonography and showing percent atheroma volume (PAV) greater than 30% are randomly assigned to treatment with ten infusions of CER-001 3 mg/kg or matching placebo, administered at weekly intervals. Intracoronary ultrasonography is repeated at the end of the treatment period.</p>
</sec>
<sec><title>Results</title>
<p>The primary endpoint is the nominal change in PAV. Safety and tolerability will also be evaluated.</p>
</sec>
<sec><title>Conclusions</title>
<p>CARAT will establish whether serial 3 mg/kg infusions of an engineered pre-beta HDL mimetic containing SM and dipalmitoyl phosphatidlyglycerol (CER-001) will regress atherosclerotic plaque in patients with a recent ACS.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">Cardiovasc Diagn Ther</journal-id>
<journal-id journal-id-type="iso-abbrev">Cardiovasc Diagn Ther</journal-id>
<journal-id journal-id-type="publisher-id">CDT</journal-id>
<journal-title-group><journal-title>Cardiovascular Diagnosis and Therapy</journal-title>
</journal-title-group>
<issn pub-type="ppub">2223-3652</issn>
<issn pub-type="epub">2223-3660</issn>
<publisher><publisher-name>AME Publishing Company</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">28164012</article-id>
<article-id pub-id-type="pmc">5253449</article-id>
<article-id pub-id-type="publisher-id">cdt-07-01-045</article-id>
<article-id pub-id-type="doi">10.21037/cdt.2017.01.01</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Effect of serial infusions of reconstituted high-density lipoprotein (CER-001) on coronary atherosclerosis: rationale and design of the CARAT study</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Andrews</surname>
<given-names>Jordan</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Janssan</surname>
<given-names>Alex</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nguyen</surname>
<given-names>Tracy</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pisaniello</surname>
<given-names>Anthony D.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Scherer</surname>
<given-names>Daniel J.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kastelein</surname>
<given-names>John J. P.</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Merkely</surname>
<given-names>Bela</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nissen</surname>
<given-names>Steven E.</given-names>
</name>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ray</surname>
<given-names>Kausik</given-names>
</name>
<xref ref-type="aff" rid="aff5"><sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schwartz</surname>
<given-names>Gregory G.</given-names>
</name>
<xref ref-type="aff" rid="aff6"><sup>6</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Worthley</surname>
<given-names>Stephen G.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Keyserling</surname>
<given-names>Connie</given-names>
</name>
<xref ref-type="aff" rid="aff7"><sup>7</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dasseux</surname>
<given-names>Jean-Louis</given-names>
</name>
<xref ref-type="aff" rid="aff7"><sup>7</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Butters</surname>
<given-names>Julie</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Girardi</surname>
<given-names>Jacinta</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Miller</surname>
<given-names>Rosemary</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Nicholls</surname>
<given-names>Stephen J.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<aff id="aff1"><label>1</label>
South Australian Health and Medical Research Institute, University of Adelaide, Adelaide,<country>Australia</country>
</aff>
<aff id="aff2"><label>2</label>
Academic Medical Center, University of Amsterdam, Amsterdam,<country>The Netherlands</country>
;</aff>
<aff id="aff3"><label>3</label>
Heart and Vascular Center, Semmelweis University, Budapest,<country>Hungary</country>
;</aff>
<aff id="aff4"><label>4</label>
Cleveland Clinic, Cleveland, Ohio,<country>USA</country>
;</aff>
<aff id="aff5"><label>5</label>
School of Public Health, Imperial College London, London,<country>UK</country>
;</aff>
<aff id="aff6"><label>6</label>
University of Colorado School of Medicine, Denver, CO,<country>USA</country>
;</aff>
<aff id="aff7"><label>7</label>
Cerenis Pharmaceuticals, Toulouse,<country>France</country>
</aff>
</contrib-group>
<author-notes><fn id="afn1"><p><italic>Contributions:</italic>
 (I) Conception and design: SJ Nicholls, J Butters, J Girardi, R Miller, J Andrews, C Keyserling, JL Dasseux; (II) Administrative support: J Butters, J Andrews, J Girardi, R Miller, C Keyserling; (III) Provision of study materials or patients: B Merkely, GG Schwartz, SJ Nicholls; (IV) Collection and assembly of data: J Andrews, A Janssan, T Nguyen, AD Pisaniello, DJ Scherer, C Keyserling, J Butters, SJ Nicholls; (V) Data analysis and interpretation: None; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.</p>
</fn>
<corresp id="cor1"><italic>Correspondence to:</italic>
 Stephen J. Nicholls, MBBS, PhD. South Australian Health and Medical Research Institute, University of Adelaide, PO Box 11060, Adelaide, SA 5001, Australia. Email: <email xlink:href="stephen.nicholls@sahmri.com">stephen.nicholls@sahmri.com</email>
.</corresp>
</author-notes>
<pub-date pub-type="epub-ppub"><month>2</month>
<year>2017</year>
</pub-date>
<pmc-comment>Fake ppub date generated by PMC from publisher 
 							pub-date/@pub-type='epub-ppub' </pmc-comment>
      <pub-date pub-type="ppub"><month>2</month>
<year>2017</year>
</pub-date>
<volume>7</volume>
<issue>1</issue>
<fpage>45</fpage>
<lpage>51</lpage>
<history><date date-type="received"><day>05</day>
<month>6</month>
<year>2016</year>
</date>
<date date-type="accepted"><day>20</day>
<month>10</month>
<year>2016</year>
</date>
</history>
<permissions><copyright-statement>2017 Cardiovascular Diagnosis and Therapy. All rights reserved.</copyright-statement>
<copyright-year>2017</copyright-year>
<copyright-holder>Cardiovascular Diagnosis and Therapy.</copyright-holder>
</permissions>
<abstract><sec><title>Background</title>
<p>High-density lipoprotein (HDL) is believed to have atheroprotective properties, but an effective HDL-based therapy remains elusive. Early studies have suggested that infusion of reconstituted HDL promotes reverse cholesterol transport and vascular reactivity. The CER-001 Atherosclerosis Regression Acute Coronary Syndrome Trial (CARAT) is investigating the impact of infusing an engineered pre-beta HDL mimetic containing sphingomyelin (SM) and dipalmitoyl phosphatidlyglycerol (CER-001) on coronary atheroma volume in patients with a recent acute coronary syndrome (ACS).</p>
</sec>
<sec><title>Methods</title>
<p>The CARAT is a phase 2, multicenter trial in which 292 patients with an ACS undergoing intracoronary ultrasonography and showing percent atheroma volume (PAV) greater than 30% are randomly assigned to treatment with ten infusions of CER-001 3 mg/kg or matching placebo, administered at weekly intervals. Intracoronary ultrasonography is repeated at the end of the treatment period.</p>
</sec>
<sec><title>Results</title>
<p>The primary endpoint is the nominal change in PAV. Safety and tolerability will also be evaluated.</p>
</sec>
<sec><title>Conclusions</title>
<p>CARAT will establish whether serial 3 mg/kg infusions of an engineered pre-beta HDL mimetic containing SM and dipalmitoyl phosphatidlyglycerol (CER-001) will regress atherosclerotic plaque in patients with a recent ACS.</p>
</sec>
</abstract>
<kwd-group kwd-group-type="author"><title>Keywords: </title>
<kwd>Atherosclerosis</kwd>
<kwd>high-density lipoproteins (HDLs)</kwd>
<kwd>CER-001</kwd>
<kwd>intravascular ultrasound</kwd>
<kwd>clinical trial</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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