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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesis</title><author><name sortKey="Sauce, Delphine" sort="Sauce, Delphine" uniqKey="Sauce D" first="Delphine" last="Sauce">Delphine Sauce</name><affiliation><nlm:aff id="aff1">Inserm UMR S 945, Infections and Immunity, Avenir Group, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitiě-Salpêtrière, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Larsen, Martin" sort="Larsen, Martin" uniqKey="Larsen M" first="Martin" last="Larsen">Martin Larsen</name><affiliation><nlm:aff id="aff2">Immunoregulation and Immunotherapy, Inserm UMR S 945, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitiě-Salpêtrière, Paris, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Assistance Publique–Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Laboratoire d'Immunologie Cellulaire et Tissulaire, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Fastenackels, Solene" sort="Fastenackels, Solene" uniqKey="Fastenackels S" first="Solène" last="Fastenackels">Solène Fastenackels</name><affiliation><nlm:aff id="aff1">Inserm UMR S 945, Infections and Immunity, Avenir Group, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitiě-Salpêtrière, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Pauchard, Michele" sort="Pauchard, Michele" uniqKey="Pauchard M" first="Michèle" last="Pauchard">Michèle Pauchard</name><affiliation><nlm:aff id="aff4">Inserm UMR S 943, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitiě-Salpêtrière, Paris, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Assistance Publique–Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Service des Maladies Infectieuses et Tropicales, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Ait Mohand, Hocine" sort="Ait Mohand, Hocine" uniqKey="Ait Mohand H" first="Hocine" last="Ait-Mohand">Hocine Ait-Mohand</name><affiliation><nlm:aff id="aff4">Inserm UMR S 943, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitiě-Salpêtrière, Paris, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Assistance Publique–Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Service des Maladies Infectieuses et Tropicales, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Schneider, Luminita" sort="Schneider, Luminita" uniqKey="Schneider L" first="Luminita" last="Schneider">Luminita Schneider</name><affiliation><nlm:aff id="aff4">Inserm UMR S 943, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitiě-Salpêtrière, Paris, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Assistance Publique–Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Service des Maladies Infectieuses et Tropicales, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Guihot, Amelie" sort="Guihot, Amelie" uniqKey="Guihot A" first="Amélie" last="Guihot">Amélie Guihot</name><affiliation><nlm:aff id="aff1">Inserm UMR S 945, Infections and Immunity, Avenir Group, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitiě-Salpêtrière, Paris, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Assistance Publique–Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Service des Maladies Infectieuses et Tropicales, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Boufassa, Faroudy" sort="Boufassa, Faroudy" uniqKey="Boufassa F" first="Faroudy" last="Boufassa">Faroudy Boufassa</name><affiliation><nlm:aff id="aff6">Inserm U1018, Universitě Paris-Sud, Hôpital Bicêtre, Le Kremlin-Bicêtre, France;</nlm:aff></affiliation></author><author><name sortKey="Zaunders, John" sort="Zaunders, John" uniqKey="Zaunders J" first="John" last="Zaunders">John Zaunders</name><affiliation><nlm:aff id="aff7">St Vincent's Centre for Applied Medical Research and University of New South Wales, Sydney, Australia;</nlm:aff></affiliation></author><author><name sortKey="Iguertsira, Malika" sort="Iguertsira, Malika" uniqKey="Iguertsira M" first="Malika" last="Iguertsira">Malika Iguertsira</name><affiliation><nlm:aff id="aff8">Assistance Publique–Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Service de Mědecine Interne, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Bailey, Michelle" sort="Bailey, Michelle" uniqKey="Bailey M" first="Michelle" last="Bailey">Michelle Bailey</name><affiliation><nlm:aff id="aff7">St Vincent's Centre for Applied Medical Research and University of New South Wales, Sydney, Australia;</nlm:aff></affiliation></author><author><name sortKey="Gorochov, Guy" sort="Gorochov, Guy" uniqKey="Gorochov G" first="Guy" last="Gorochov">Guy Gorochov</name><affiliation><nlm:aff id="aff2">Immunoregulation and Immunotherapy, Inserm UMR S 945, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitiě-Salpêtrière, Paris, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Assistance Publique–Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Laboratoire d'Immunologie Cellulaire et Tissulaire, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Duvivier, Claudine" sort="Duvivier, Claudine" uniqKey="Duvivier C" first="Claudine" last="Duvivier">Claudine Duvivier</name><affiliation><nlm:aff id="aff9">Assistance Publique–Hopitaux (AP-HP), Groupe hospitalier Necker-Enfant malades, Service de Maladies Infectieuses et Tropicales, Paris, France;</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff id="aff11">Institut Pasteur, Centre Mědical de l'Institut Pasteur; Centre d'Infectiologie Necker-Pasteur, Děpartement Infection et Epiděmiologie, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Carcelain, Guislaine" sort="Carcelain, Guislaine" uniqKey="Carcelain G" first="Guislaine" last="Carcelain">Guislaine Carcelain</name><affiliation><nlm:aff id="aff1">Inserm UMR S 945, Infections and Immunity, Avenir Group, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitiě-Salpêtrière, Paris, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Assistance Publique–Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Laboratoire d'Immunologie Cellulaire et Tissulaire, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Kelleher, Anthony D" sort="Kelleher, Anthony D" uniqKey="Kelleher A" first="Anthony D." last="Kelleher">Anthony D. Kelleher</name><affiliation><nlm:aff id="aff7">St Vincent's Centre for Applied Medical Research and University of New South Wales, Sydney, Australia;</nlm:aff></affiliation></author><author><name sortKey="Simon, Anne" sort="Simon, Anne" uniqKey="Simon A" first="Anne" last="Simon">Anne Simon</name><affiliation><nlm:aff id="aff8">Assistance Publique–Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Service de Mědecine Interne, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Meyer, Laurence" sort="Meyer, Laurence" uniqKey="Meyer L" first="Laurence" last="Meyer">Laurence Meyer</name><affiliation><nlm:aff id="aff6">Inserm U1018, Universitě Paris-Sud, Hôpital Bicêtre, Le Kremlin-Bicêtre, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff12">Assistance Publique–Hopitaux (AP-HP), Service d'Epiděmiologie et de Santě Publique, Hôpital Bicêtre, Le Kremlin-Bicêtre, France;</nlm:aff></affiliation></author><author><name sortKey="Costagliola, Dominique" sort="Costagliola, Dominique" uniqKey="Costagliola D" first="Dominique" last="Costagliola">Dominique Costagliola</name><affiliation><nlm:aff id="aff4">Inserm UMR S 943, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitiě-Salpêtrière, Paris, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Assistance Publique–Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Service des Maladies Infectieuses et Tropicales, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Deeks, Steven G" sort="Deeks, Steven G" uniqKey="Deeks S" first="Steven G." last="Deeks">Steven G. Deeks</name><affiliation><nlm:aff id="aff13">HIV/AIDS Division, Department of Internal Medicine, University of California San Francisco, San Francisco, CA;</nlm:aff></affiliation></author><author><name sortKey="Lambotte, Olivier" sort="Lambotte, Olivier" uniqKey="Lambotte O" first="Olivier" last="Lambotte">Olivier Lambotte</name><affiliation><nlm:aff wicri:cut="; and" id="aff14">Assistance Publique–Hopitaux de Paris (AP-HP), Department of Internal Medicine and Infectious Diseases, Hôpital Bicêtre, Le Kremlin-Bicêtre, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff15">Inserm U802, Universitě Paris-Sud, Hôpital Bicêtre, Le Kremlin-Bicêtre, France</nlm:aff></affiliation></author><author><name sortKey="Autran, Brigitte" sort="Autran, Brigitte" uniqKey="Autran B" first="Brigitte" last="Autran">Brigitte Autran</name><affiliation><nlm:aff id="aff1">Inserm UMR S 945, Infections and Immunity, Avenir Group, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitiě-Salpêtrière, Paris, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Assistance Publique–Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Laboratoire d'Immunologie Cellulaire et Tissulaire, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Hunt, Peter W" sort="Hunt, Peter W" uniqKey="Hunt P" first="Peter W." last="Hunt">Peter W. Hunt</name><affiliation><nlm:aff id="aff13">HIV/AIDS Division, Department of Internal Medicine, University of California San Francisco, San Francisco, CA;</nlm:aff></affiliation></author><author><name sortKey="Katlama, Christine" sort="Katlama, Christine" uniqKey="Katlama C" first="Christine" last="Katlama">Christine Katlama</name><affiliation><nlm:aff id="aff4">Inserm UMR S 943, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitiě-Salpêtrière, Paris, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Assistance Publique–Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Service des Maladies Infectieuses et Tropicales, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Appay, Victor" sort="Appay, Victor" uniqKey="Appay V" first="Victor" last="Appay">Victor Appay</name><affiliation><nlm:aff id="aff1">Inserm UMR S 945, Infections and Immunity, Avenir Group, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitiě-Salpêtrière, Paris, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Assistance Publique–Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Laboratoire d'Immunologie Cellulaire et Tissulaire, Paris, France;</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21436070</idno><idno type="pmc">3109539</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109539</idno><idno type="RBID">PMC:3109539</idno><idno type="doi">10.1182/blood-2011-01-331306</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">001790</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001790</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesis</title><author><name sortKey="Sauce, Delphine" sort="Sauce, Delphine" uniqKey="Sauce D" first="Delphine" last="Sauce">Delphine Sauce</name><affiliation><nlm:aff id="aff1">Inserm UMR S 945, Infections and Immunity, Avenir Group, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitiě-Salpêtrière, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Larsen, Martin" sort="Larsen, Martin" uniqKey="Larsen M" first="Martin" last="Larsen">Martin Larsen</name><affiliation><nlm:aff id="aff2">Immunoregulation and Immunotherapy, Inserm UMR S 945, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitiě-Salpêtrière, Paris, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Assistance Publique–Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Laboratoire d'Immunologie Cellulaire et Tissulaire, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Fastenackels, Solene" sort="Fastenackels, Solene" uniqKey="Fastenackels S" first="Solène" last="Fastenackels">Solène Fastenackels</name><affiliation><nlm:aff id="aff1">Inserm UMR S 945, Infections and Immunity, Avenir Group, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitiě-Salpêtrière, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Pauchard, Michele" sort="Pauchard, Michele" uniqKey="Pauchard M" first="Michèle" last="Pauchard">Michèle Pauchard</name><affiliation><nlm:aff id="aff4">Inserm UMR S 943, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitiě-Salpêtrière, Paris, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Assistance Publique–Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Service des Maladies Infectieuses et Tropicales, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Ait Mohand, Hocine" sort="Ait Mohand, Hocine" uniqKey="Ait Mohand H" first="Hocine" last="Ait-Mohand">Hocine Ait-Mohand</name><affiliation><nlm:aff id="aff4">Inserm UMR S 943, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitiě-Salpêtrière, Paris, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Assistance Publique–Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Service des Maladies Infectieuses et Tropicales, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Schneider, Luminita" sort="Schneider, Luminita" uniqKey="Schneider L" first="Luminita" last="Schneider">Luminita Schneider</name><affiliation><nlm:aff id="aff4">Inserm UMR S 943, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitiě-Salpêtrière, Paris, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Assistance Publique–Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Service des Maladies Infectieuses et Tropicales, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Guihot, Amelie" sort="Guihot, Amelie" uniqKey="Guihot A" first="Amélie" last="Guihot">Amélie Guihot</name><affiliation><nlm:aff id="aff1">Inserm UMR S 945, Infections and Immunity, Avenir Group, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitiě-Salpêtrière, Paris, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Assistance Publique–Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Service des Maladies Infectieuses et Tropicales, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Boufassa, Faroudy" sort="Boufassa, Faroudy" uniqKey="Boufassa F" first="Faroudy" last="Boufassa">Faroudy Boufassa</name><affiliation><nlm:aff id="aff6">Inserm U1018, Universitě Paris-Sud, Hôpital Bicêtre, Le Kremlin-Bicêtre, France;</nlm:aff></affiliation></author><author><name sortKey="Zaunders, John" sort="Zaunders, John" uniqKey="Zaunders J" first="John" last="Zaunders">John Zaunders</name><affiliation><nlm:aff id="aff7">St Vincent's Centre for Applied Medical Research and University of New South Wales, Sydney, Australia;</nlm:aff></affiliation></author><author><name sortKey="Iguertsira, Malika" sort="Iguertsira, Malika" uniqKey="Iguertsira M" first="Malika" last="Iguertsira">Malika Iguertsira</name><affiliation><nlm:aff id="aff8">Assistance Publique–Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Service de Mědecine Interne, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Bailey, Michelle" sort="Bailey, Michelle" uniqKey="Bailey M" first="Michelle" last="Bailey">Michelle Bailey</name><affiliation><nlm:aff id="aff7">St Vincent's Centre for Applied Medical Research and University of New South Wales, Sydney, Australia;</nlm:aff></affiliation></author><author><name sortKey="Gorochov, Guy" sort="Gorochov, Guy" uniqKey="Gorochov G" first="Guy" last="Gorochov">Guy Gorochov</name><affiliation><nlm:aff id="aff2">Immunoregulation and Immunotherapy, Inserm UMR S 945, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitiě-Salpêtrière, Paris, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Assistance Publique–Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Laboratoire d'Immunologie Cellulaire et Tissulaire, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Duvivier, Claudine" sort="Duvivier, Claudine" uniqKey="Duvivier C" first="Claudine" last="Duvivier">Claudine Duvivier</name><affiliation><nlm:aff id="aff9">Assistance Publique–Hopitaux (AP-HP), Groupe hospitalier Necker-Enfant malades, Service de Maladies Infectieuses et Tropicales, Paris, France;</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff id="aff11">Institut Pasteur, Centre Mědical de l'Institut Pasteur; Centre d'Infectiologie Necker-Pasteur, Děpartement Infection et Epiděmiologie, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Carcelain, Guislaine" sort="Carcelain, Guislaine" uniqKey="Carcelain G" first="Guislaine" last="Carcelain">Guislaine Carcelain</name><affiliation><nlm:aff id="aff1">Inserm UMR S 945, Infections and Immunity, Avenir Group, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitiě-Salpêtrière, Paris, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Assistance Publique–Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Laboratoire d'Immunologie Cellulaire et Tissulaire, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Kelleher, Anthony D" sort="Kelleher, Anthony D" uniqKey="Kelleher A" first="Anthony D." last="Kelleher">Anthony D. Kelleher</name><affiliation><nlm:aff id="aff7">St Vincent's Centre for Applied Medical Research and University of New South Wales, Sydney, Australia;</nlm:aff></affiliation></author><author><name sortKey="Simon, Anne" sort="Simon, Anne" uniqKey="Simon A" first="Anne" last="Simon">Anne Simon</name><affiliation><nlm:aff id="aff8">Assistance Publique–Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Service de Mědecine Interne, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Meyer, Laurence" sort="Meyer, Laurence" uniqKey="Meyer L" first="Laurence" last="Meyer">Laurence Meyer</name><affiliation><nlm:aff id="aff6">Inserm U1018, Universitě Paris-Sud, Hôpital Bicêtre, Le Kremlin-Bicêtre, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff12">Assistance Publique–Hopitaux (AP-HP), Service d'Epiděmiologie et de Santě Publique, Hôpital Bicêtre, Le Kremlin-Bicêtre, France;</nlm:aff></affiliation></author><author><name sortKey="Costagliola, Dominique" sort="Costagliola, Dominique" uniqKey="Costagliola D" first="Dominique" last="Costagliola">Dominique Costagliola</name><affiliation><nlm:aff id="aff4">Inserm UMR S 943, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitiě-Salpêtrière, Paris, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Assistance Publique–Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Service des Maladies Infectieuses et Tropicales, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Deeks, Steven G" sort="Deeks, Steven G" uniqKey="Deeks S" first="Steven G." last="Deeks">Steven G. Deeks</name><affiliation><nlm:aff id="aff13">HIV/AIDS Division, Department of Internal Medicine, University of California San Francisco, San Francisco, CA;</nlm:aff></affiliation></author><author><name sortKey="Lambotte, Olivier" sort="Lambotte, Olivier" uniqKey="Lambotte O" first="Olivier" last="Lambotte">Olivier Lambotte</name><affiliation><nlm:aff wicri:cut="; and" id="aff14">Assistance Publique–Hopitaux de Paris (AP-HP), Department of Internal Medicine and Infectious Diseases, Hôpital Bicêtre, Le Kremlin-Bicêtre, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff15">Inserm U802, Universitě Paris-Sud, Hôpital Bicêtre, Le Kremlin-Bicêtre, France</nlm:aff></affiliation></author><author><name sortKey="Autran, Brigitte" sort="Autran, Brigitte" uniqKey="Autran B" first="Brigitte" last="Autran">Brigitte Autran</name><affiliation><nlm:aff id="aff1">Inserm UMR S 945, Infections and Immunity, Avenir Group, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitiě-Salpêtrière, Paris, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Assistance Publique–Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Laboratoire d'Immunologie Cellulaire et Tissulaire, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Hunt, Peter W" sort="Hunt, Peter W" uniqKey="Hunt P" first="Peter W." last="Hunt">Peter W. Hunt</name><affiliation><nlm:aff id="aff13">HIV/AIDS Division, Department of Internal Medicine, University of California San Francisco, San Francisco, CA;</nlm:aff></affiliation></author><author><name sortKey="Katlama, Christine" sort="Katlama, Christine" uniqKey="Katlama C" first="Christine" last="Katlama">Christine Katlama</name><affiliation><nlm:aff id="aff4">Inserm UMR S 943, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitiě-Salpêtrière, Paris, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Assistance Publique–Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Service des Maladies Infectieuses et Tropicales, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Appay, Victor" sort="Appay, Victor" uniqKey="Appay V" first="Victor" last="Appay">Victor Appay</name><affiliation><nlm:aff id="aff1">Inserm UMR S 945, Infections and Immunity, Avenir Group, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitiě-Salpêtrière, Paris, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Assistance Publique–Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Laboratoire d'Immunologie Cellulaire et Tissulaire, Paris, France;</nlm:aff></affiliation></author></analytic><series><title level="j">Blood</title><idno type="ISSN">0006-4971</idno><idno type="eISSN">1528-0020</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The mechanisms of CD4<sup>+</sup> T-cell count decline, the hallmark of HIV disease progression, and its relationship to elevated levels of immune activation are not fully understood. Massive depletion of CD4<sup>+</sup> T cells occurs during the course of HIV-1 infection, so that maintenance of adequate CD4<sup>+</sup> T-cell levels probably depends primarily on the capacity to renew depleted lymphocytes, that is, the lymphopoiesis. We performed here a comprehensive study of quantitative and qualitative attributes of CD34<sup>+</sup> hematopoietic progenitor cells directly from the blood of a large set of HIV-infected persons compared with uninfected donors, in particular the elderly. Our analyses underline a marked impairment of primary immune resources with the failure to maintain adequate lymphocyte counts. Systemic immune activation emerges as a major correlate of altered lymphopoiesis, which can be partially reversed with prolonged antiretroviral therapy. Importantly, HIV disease progression despite elite control of HIV replication or virologic success on antiretroviral treatment is associated with persistent damage to the lymphopoietic system or exhaustion of lymphopoiesis. These findings highlight the importance of primary hematopoietic resources in HIV pathogenesis and the response to antiretroviral treatments.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Blood</journal-id><journal-id journal-id-type="hwp">bloodjournal</journal-id><journal-id journal-id-type="pmc">blood</journal-id><journal-id journal-id-type="publisher-id">Blood</journal-id><journal-title-group><journal-title>Blood</journal-title></journal-title-group><issn pub-type="ppub">0006-4971</issn><issn pub-type="epub">1528-0020</issn><publisher><publisher-name>American Society of Hematology</publisher-name><publisher-loc>Washington, DC</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21436070</article-id><article-id pub-id-type="pmc">3109539</article-id><article-id pub-id-type="publisher-id">2011/331306</article-id><article-id pub-id-type="doi">10.1182/blood-2011-01-331306</article-id><article-categories><subj-group subj-group-type="heading"><subject>Clinical Trials and Observations</subject></subj-group><subj-group subj-group-type="heading"><subject>Immunobiology</subject></subj-group></article-categories><title-group><article-title>HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Sauce</surname><given-names>Delphine</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Larsen</surname><given-names>Martin</given-names></name><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>Fastenackels</surname><given-names>Solène</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>Pauchard</surname><given-names>Michèle</given-names></name><xref ref-type="aff" rid="aff4">4</xref><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Ait-Mohand</surname><given-names>Hocine</given-names></name><xref ref-type="aff" rid="aff4">4</xref><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Schneider</surname><given-names>Luminita</given-names></name><xref ref-type="aff" rid="aff4">4</xref><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Guihot</surname><given-names>Amélie</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Boufassa</surname><given-names>Faroudy</given-names></name><xref ref-type="aff" rid="aff6">6</xref></contrib><contrib contrib-type="author"><name><surname>Zaunders</surname><given-names>John</given-names></name><xref ref-type="aff" rid="aff7">7</xref></contrib><contrib contrib-type="author"><name><surname>Iguertsira</surname><given-names>Malika</given-names></name><xref ref-type="aff" rid="aff8">8</xref></contrib><contrib contrib-type="author"><name><surname>Bailey</surname><given-names>Michelle</given-names></name><xref ref-type="aff" rid="aff7">7</xref></contrib><contrib contrib-type="author"><name><surname>Gorochov</surname><given-names>Guy</given-names></name><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Duvivier</surname><given-names>Claudine</given-names></name><xref ref-type="aff" rid="aff9">9</xref><xref ref-type="aff" rid="aff10"></xref><xref ref-type="aff" rid="aff11">11</xref></contrib><contrib contrib-type="author"><name><surname>Carcelain</surname><given-names>Guislaine</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Kelleher</surname><given-names>Anthony D.</given-names></name><xref ref-type="aff" rid="aff7">7</xref></contrib><contrib contrib-type="author"><name><surname>Simon</surname><given-names>Anne</given-names></name><xref ref-type="aff" rid="aff8">8</xref></contrib><contrib contrib-type="author"><name><surname>Meyer</surname><given-names>Laurence</given-names></name><xref ref-type="aff" rid="aff6">6</xref><xref ref-type="aff" rid="aff12">12</xref></contrib><contrib contrib-type="author"><name><surname>Costagliola</surname><given-names>Dominique</given-names></name><xref ref-type="aff" rid="aff4">4</xref><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Deeks</surname><given-names>Steven G.</given-names></name><xref ref-type="aff" rid="aff13">13</xref></contrib><contrib contrib-type="author"><name><surname>Lambotte</surname><given-names>Olivier</given-names></name><xref ref-type="aff" rid="aff14">14</xref><xref ref-type="aff" rid="aff15">15</xref></contrib><contrib contrib-type="author"><name><surname>Autran</surname><given-names>Brigitte</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Hunt</surname><given-names>Peter W.</given-names></name><xref ref-type="aff" rid="aff13">13</xref></contrib><contrib contrib-type="author"><name><surname>Katlama</surname><given-names>Christine</given-names></name><xref ref-type="aff" rid="aff4">4</xref><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Appay</surname><given-names>Victor</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff3">3</xref></contrib><aff id="aff1"><label>1</label>Inserm UMR S 945, Infections and Immunity, Avenir Group, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitiě-Salpêtrière, Paris, France;</aff><aff id="aff2"><label>2</label>Immunoregulation and Immunotherapy, Inserm UMR S 945, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitiě-Salpêtrière, Paris, France;</aff><aff id="aff3"><label>3</label>Assistance Publique–Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Laboratoire d'Immunologie Cellulaire et Tissulaire, Paris, France;</aff><aff id="aff4"><label>4</label>Inserm UMR S 943, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitiě-Salpêtrière, Paris, France;</aff><aff id="aff5"><label>5</label>Assistance Publique–Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Service des Maladies Infectieuses et Tropicales, Paris, France;</aff><aff id="aff6"><label>6</label>Inserm U1018, Universitě Paris-Sud, Hôpital Bicêtre, Le Kremlin-Bicêtre, France;</aff><aff id="aff7"><label>7</label>St Vincent's Centre for Applied Medical Research and University of New South Wales, Sydney, Australia;</aff><aff id="aff8"><label>8</label>Assistance Publique–Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Service de Mědecine Interne, Paris, France;</aff><aff id="aff9"><label>9</label>Assistance Publique–Hopitaux (AP-HP), Groupe hospitalier Necker-Enfant malades, Service de Maladies Infectieuses et Tropicales, Paris, France;</aff><aff id="aff10"><label>10</label>Universitě Descartes, Paris, France;</aff><aff id="aff11"><label>11</label>Institut Pasteur, Centre Mědical de l'Institut Pasteur; Centre d'Infectiologie Necker-Pasteur, Děpartement Infection et Epiděmiologie, Paris, France;</aff><aff id="aff12"><label>12</label>Assistance Publique–Hopitaux (AP-HP), Service d'Epiděmiologie et de Santě Publique, Hôpital Bicêtre, Le Kremlin-Bicêtre, France;</aff><aff id="aff13"><label>13</label>HIV/AIDS Division, Department of Internal Medicine, University of California San Francisco, San Francisco, CA;</aff><aff id="aff14"><label>14</label>Assistance Publique–Hopitaux de Paris (AP-HP), Department of Internal Medicine and Infectious Diseases, Hôpital Bicêtre, Le Kremlin-Bicêtre, France; and</aff><aff id="aff15"><label>15</label>Inserm U802, Universitě Paris-Sud, Hôpital Bicêtre, Le Kremlin-Bicêtre, France</aff></contrib-group><author-notes><fn fn-type="equal" id="FN1"><label>*</label><p>M.L. and S.F. contributed equally to this study.</p></fn></author-notes><pub-date pub-type="ppub"><day>12</day><month>5</month><year>2011</year></pub-date><pub-date pub-type="epreprint"><day>24</day><month>3</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>12</day><month>5</month><year>2012</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>117</volume><issue>19</issue><fpage>5142</fpage><lpage>5151</lpage><history><date date-type="received"><day>20</day><month>1</month><year>2011</year></date><date date-type="accepted"><day>12</day><month>3</month><year>2011</year></date></history><permissions><copyright-statement>© 2011 by The American Society of Hematology</copyright-statement><copyright-year>2011</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zh801911005142.pdf"></self-uri><abstract><p>The mechanisms of CD4<sup>+</sup> T-cell count decline, the hallmark of HIV disease progression, and its relationship to elevated levels of immune activation are not fully understood. Massive depletion of CD4<sup>+</sup> T cells occurs during the course of HIV-1 infection, so that maintenance of adequate CD4<sup>+</sup> T-cell levels probably depends primarily on the capacity to renew depleted lymphocytes, that is, the lymphopoiesis. We performed here a comprehensive study of quantitative and qualitative attributes of CD34<sup>+</sup> hematopoietic progenitor cells directly from the blood of a large set of HIV-infected persons compared with uninfected donors, in particular the elderly. Our analyses underline a marked impairment of primary immune resources with the failure to maintain adequate lymphocyte counts. Systemic immune activation emerges as a major correlate of altered lymphopoiesis, which can be partially reversed with prolonged antiretroviral therapy. Importantly, HIV disease progression despite elite control of HIV replication or virologic success on antiretroviral treatment is associated with persistent damage to the lymphopoietic system or exhaustion of lymphopoiesis. These findings highlight the importance of primary hematopoietic resources in HIV pathogenesis and the response to antiretroviral treatments.</p></abstract><funding-group><award-group><funding-source id="CS100">National Institutes of Health</funding-source></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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