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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate <italic>NRBF2</italic>
Expression</title>
<author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name>
<affiliation><nlm:aff id="aff1">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mccue, Karen" sort="Mccue, Karen" uniqKey="Mccue K" first="Karen" last="Mccue">Karen Mccue</name>
<affiliation><nlm:aff id="aff2">Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name>
<affiliation><nlm:aff id="aff2">Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name>
<affiliation><nlm:aff id="aff3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nord, Silje" sort="Nord, Silje" uniqKey="Nord S" first="Silje" last="Nord">Silje Nord</name>
<affiliation><nlm:aff id="aff4">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, 0310 Oslo, Norway</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff5">K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Kirkeveien 166, 0450 Oslo, Norway</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kar, Siddhartha" sort="Kar, Siddhartha" uniqKey="Kar S" first="Siddhartha" last="Kar">Siddhartha Kar</name>
<affiliation><nlm:aff id="aff6">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name>
<affiliation><nlm:aff id="aff1">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Thompson, Deborah" sort="Thompson, Deborah" uniqKey="Thompson D" first="Deborah" last="Thompson">Deborah Thompson</name>
<affiliation><nlm:aff id="aff3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ghoussaini, Maya" sort="Ghoussaini, Maya" uniqKey="Ghoussaini M" first="Maya" last="Ghoussaini">Maya Ghoussaini</name>
<affiliation><nlm:aff id="aff6">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name>
<affiliation><nlm:aff id="aff3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name>
<affiliation><nlm:aff id="aff3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name>
<affiliation><nlm:aff id="aff3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Canisius, Sander" sort="Canisius, Sander" uniqKey="Canisius S" first="Sander" last="Canisius">Sander Canisius</name>
<affiliation><nlm:aff id="aff7">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Scott, Christopher G" sort="Scott, Christopher G" uniqKey="Scott C" first="Christopher G." last="Scott">Christopher G. Scott</name>
<affiliation><nlm:aff id="aff8">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name>
<affiliation><nlm:aff id="aff9">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name>
<affiliation><nlm:aff id="aff9">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name>
<affiliation><nlm:aff id="aff10">Department of Pathology, The University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stone, Jennifer" sort="Stone, Jennifer" uniqKey="Stone J" first="Jennifer" last="Stone">Jennifer Stone</name>
<affiliation><nlm:aff id="aff11">Centre for Genetic Origins of Health and Disease, University of Western Australia, Crawley, WA 6009, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name>
<affiliation><nlm:aff id="aff7">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name>
<affiliation><nlm:aff id="aff7">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J." last="Scott">Rodney J. Scott</name>
<affiliation><nlm:aff id="aff12">Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Newcastle, NSW 2308, Australia</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff13">Division of Molecular Medicine, Pathology North, John Hunter Hospital and The Hunter Medical Research Institute, Newcastle, NSW 2305, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name>
<affiliation><nlm:aff id="aff14">Division of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name>
<affiliation><nlm:aff id="aff14">Division of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff15">Institute of Population Health, University of Manchester, Manchester M13 9PL, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name>
<affiliation><nlm:aff id="aff16">University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name>
<affiliation><nlm:aff id="aff17">Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name>
<affiliation><nlm:aff id="aff16">University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff18">Department of Medicine Division of Hematology and Oncology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Heusinger, Katharina" sort="Heusinger, Katharina" uniqKey="Heusinger K" first="Katharina" last="Heusinger">Katharina Heusinger</name>
<affiliation><nlm:aff id="aff16">University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name>
<affiliation><nlm:aff id="aff19">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name>
<affiliation><nlm:aff id="aff19">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name>
<affiliation><nlm:aff id="aff20">Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford OX3 7BN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name>
<affiliation><nlm:aff id="aff21">Research Oncology, Division of Cancer Studies, King’s College London, Guy’s Hospital, London SE1 9RT, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name>
<affiliation><nlm:aff id="aff22">National Center for Tumor Diseases, University of Heidelberg, 69120 Heidelberg, Germany</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff23">Division of Molecular Genetic Epidemiology, German Cancer Research Centre (DZFK), 69047 Heidelberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name>
<affiliation><nlm:aff id="aff22">National Center for Tumor Diseases, University of Heidelberg, 69120 Heidelberg, Germany</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff24">Department of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name>
<affiliation><nlm:aff id="aff25">University Paris-Sud, UMRS 1018, 94807 Villejuif, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff26">INSERM (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 94807 Villejuif, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name>
<affiliation><nlm:aff id="aff25">University Paris-Sud, UMRS 1018, 94807 Villejuif, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff26">INSERM (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 94807 Villejuif, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name>
<affiliation><nlm:aff id="aff27">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff28">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff29">Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name>
<affiliation><nlm:aff id="aff30">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name>
<affiliation><nlm:aff id="aff31">Human Genotyping (CEGEN) Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff32">Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid 28029, Spain</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff33">Biomedical Network on Rare Diseases (CIBERER), Madrid 28029, Spain</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name>
<affiliation><nlm:aff id="aff31">Human Genotyping (CEGEN) Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name>
<affiliation><nlm:aff id="aff34">Department of Epidemiology, University of California Irvine, Irvine, CA 92697, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name>
<affiliation><nlm:aff id="aff35">Beckman Research Institute of City of Hope, Duarte, CA 91010, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name>
<affiliation><nlm:aff id="aff36">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name>
<affiliation><nlm:aff id="aff36">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff37">Division of Preventive Oncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff38">German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Engel, Christoph" sort="Engel, Christoph" uniqKey="Engel C" first="Christoph" last="Engel">Christoph Engel</name>
<affiliation><nlm:aff id="aff39">Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04107 Leipzig, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name>
<affiliation><nlm:aff id="aff40">Division of Gynaecology and Obstetrics, Technische Universität München, 81675 Munich, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name>
<affiliation><nlm:aff id="aff41">Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne 50932, Germany</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff42">Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, Cologne 50937, Germany</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff43">Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne 50937, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Arnold, Norbert" sort="Arnold, Norbert" uniqKey="Arnold N" first="Norbert" last="Arnold">Norbert Arnold</name>
<affiliation><nlm:aff id="aff44">Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, 24105 Kiel, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name>
<affiliation><nlm:aff id="aff38">German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff45">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff46">University of Tübingen, 72074 Tübingen, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name>
<affiliation><nlm:aff id="aff47">Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name>
<affiliation><nlm:aff id="aff48">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Khan, Sofia" sort="Khan, Sofia" uniqKey="Khan S" first="Sofia" last="Khan">Sofia Khan</name>
<affiliation><nlm:aff id="aff49">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, 00029 HUS, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name>
<affiliation><nlm:aff id="aff49">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, 00029 HUS, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ito, Hidemi" sort="Ito, Hidemi" uniqKey="Ito H" first="Hidemi" last="Ito">Hidemi Ito</name>
<affiliation><nlm:aff id="aff50">Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi 464-8681, Japan</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Matsuo, Keitaro" sort="Matsuo, Keitaro" uniqKey="Matsuo K" first="Keitaro" last="Matsuo">Keitaro Matsuo</name>
<affiliation><nlm:aff id="aff51">Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka 812-8582, Japan</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name>
<affiliation><nlm:aff id="aff52">Department of Radiation Oncology, Hannover Medical School, 30625 Hannover, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name>
<affiliation><nlm:aff id="aff53">Gynaecology Research Unit, Hannover Medical School, 30625 Hannover, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name>
<affiliation><nlm:aff id="aff54">Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name>
<affiliation><nlm:aff id="aff55">Department of Oncology - Pathology, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name>
<affiliation><nlm:aff id="aff56">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio 70211, Finland</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff57">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio 70211, Finland</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff58">Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio 70211, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name>
<affiliation><nlm:aff id="aff56">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio 70211, Finland</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff57">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio 70211, Finland</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff58">Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio 70211, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tseng, Chiu Chen" sort="Tseng, Chiu Chen" uniqKey="Tseng C" first="Chiu-Chen" last="Tseng">Chiu-Chen Tseng</name>
<affiliation><nlm:aff id="aff59">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wu, Anna H" sort="Wu, Anna H" uniqKey="Wu A" first="Anna H." last="Wu">Anna H. Wu</name>
<affiliation><nlm:aff id="aff59">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Floris, Giuseppe" sort="Floris, Giuseppe" uniqKey="Floris G" first="Giuseppe" last="Floris">Giuseppe Floris</name>
<affiliation><nlm:aff id="aff60">University Hospital Gashuisberg, 3000 Leuven, Belgium</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name>
<affiliation><nlm:aff id="aff61">Vesalius Research Center (VRC), VIB, Leuven 3000, Belgium</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff62">Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven 3000, Belgium</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name>
<affiliation><nlm:aff id="aff48">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name>
<affiliation><nlm:aff id="aff63">IFOM, the FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, 20139 Milan, Italy</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name>
<affiliation><nlm:aff id="aff64">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), 20133 Milan, Italy</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name>
<affiliation><nlm:aff id="aff65">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name>
<affiliation><nlm:aff id="aff8">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
<affiliation><nlm:aff id="aff9">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff66">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3053, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name>
<affiliation><nlm:aff id="aff67">Anatomical Pathology, The Alfred Hospital, Melbourne, VIC 3004, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name>
<affiliation><nlm:aff id="aff9">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff66">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3053, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dugue, Pierre Antoine" sort="Dugue, Pierre Antoine" uniqKey="Dugue P" first="Pierre-Antoine" last="Dugué">Pierre-Antoine Dugué</name>
<affiliation><nlm:aff id="aff66">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3053, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name>
<affiliation><nlm:aff id="aff59">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Maskarinec, Gertraud" sort="Maskarinec, Gertraud" uniqKey="Maskarinec G" first="Gertraud" last="Maskarinec">Gertraud Maskarinec</name>
<affiliation><nlm:aff id="aff68">Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Woolcott, Christy" sort="Woolcott, Christy" uniqKey="Woolcott C" first="Christy" last="Woolcott">Christy Woolcott</name>
<affiliation><nlm:aff id="aff69">Departments of Obstetrics & Gynaecology and Pediatrics, Dalhousie University, Halifax, NS B3H 4R2, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name>
<affiliation><nlm:aff id="aff59">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Goldberg, Mark S" sort="Goldberg, Mark S" uniqKey="Goldberg M" first="Mark S." last="Goldberg">Mark S. Goldberg</name>
<affiliation><nlm:aff id="aff70">Department of Medicine, McGill University, Montreal, QC H3A 1W7, Canada</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff71">Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, Montreal, QC H3H 2R9, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name>
<affiliation><nlm:aff id="aff72">Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City, QC G1V 4G2, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Teo, Soo H" sort="Teo, Soo H" uniqKey="Teo S" first="Soo H." last="Teo">Soo H. Teo</name>
<affiliation><nlm:aff id="aff73">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre (UMMC), 50603 Kuala Lumpur, Malaysia</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff74">Cancer Research Initiatives Foundation, Sime Darby Medical Centre, 47500 Subang Jaya, Malaysia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mariapun, Shivaani" sort="Mariapun, Shivaani" uniqKey="Mariapun S" first="Shivaani" last="Mariapun">Shivaani Mariapun</name>
<affiliation><nlm:aff id="aff73">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre (UMMC), 50603 Kuala Lumpur, Malaysia</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff74">Cancer Research Initiatives Foundation, Sime Darby Medical Centre, 47500 Subang Jaya, Malaysia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Helland, Slaug" sort="Helland, Slaug" uniqKey="Helland " first=" Slaug" last="Helland"> Slaug Helland</name>
<affiliation><nlm:aff id="aff75">Department of Oncology, Oslo University Hospital, Radiumhospitalet, 0310 Oslo, Norway</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Haakensen, Vilde" sort="Haakensen, Vilde" uniqKey="Haakensen V" first="Vilde" last="Haakensen">Vilde Haakensen</name>
<affiliation><nlm:aff id="aff76">Department of Genetics, Oslo University Hospital, Radiumhospitalet, 0310 Oslo, Norway</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name>
<affiliation><nlm:aff id="aff77">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Beeghly Fadiel, Alicia" sort="Beeghly Fadiel, Alicia" uniqKey="Beeghly Fadiel A" first="Alicia" last="Beeghly-Fadiel">Alicia Beeghly-Fadiel</name>
<affiliation><nlm:aff id="aff77">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tamimi, Rulla" sort="Tamimi, Rulla" uniqKey="Tamimi R" first="Rulla" last="Tamimi">Rulla Tamimi</name>
<affiliation><nlm:aff id="aff78">Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff79">Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff80">Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name>
<affiliation><nlm:aff id="aff81">Department of Oncology, Oulu University Hospital and University of Oulu, 90014 Oulu, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name>
<affiliation><nlm:aff id="aff82">Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, 90014 Oulu, Finland</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff83">Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, 90220 Oulu, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name>
<affiliation><nlm:aff id="aff84">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff85">Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 3G3, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name>
<affiliation><nlm:aff id="aff86">Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff87">Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5S 3G3, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name>
<affiliation><nlm:aff id="aff88">Department of Human Genetics, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff89">Department of Pathology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tollenaar, Robert A E M" sort="Tollenaar, Robert A E M" uniqKey="Tollenaar R" first="Robert A. E. M." last="Tollenaar">Robert A. E. M. Tollenaar</name>
<affiliation><nlm:aff id="aff90">Department of Surgical Oncology, Leiden University Medical Center, 2333 ZC Leiden, the Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name>
<affiliation><nlm:aff id="aff91">Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20850, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name>
<affiliation><nlm:aff id="aff92">Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton SM2 5NG, UK</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff93">Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, London SW3 6JB, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name>
<affiliation><nlm:aff id="aff1">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name>
<affiliation><nlm:aff id="aff94">Department of Medical Oncology, Erasmus MC Cancer Institute, 3008 AE Rotterdam, the Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tilanus Linthorst, Madeleine" sort="Tilanus Linthorst, Madeleine" uniqKey="Tilanus Linthorst M" first="Madeleine" last="Tilanus-Linthorst">Madeleine Tilanus-Linthorst</name>
<affiliation><nlm:aff id="aff95">Department of Surgical Oncology, Erasmus University Medical Center, 3075 EA Rotterdam, the Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name>
<affiliation><nlm:aff id="aff96">Human Genetics Division, Genome Institute of Singapore, Singapore 138672, Singapore</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gao, Yu Tang" sort="Gao, Yu Tang" uniqKey="Gao Y" first="Yu-Tang" last="Gao">Yu-Tang Gao</name>
<affiliation><nlm:aff id="aff97">Department of Epidemiology, Shanghai Cancer Institute, Xuhui, Shanghai 200031, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name>
<affiliation><nlm:aff id="aff77">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name>
<affiliation><nlm:aff id="aff98">Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield S10 2RX, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name>
<affiliation><nlm:aff id="aff99">Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Luben, Robert" sort="Luben, Robert" uniqKey="Luben R" first="Robert" last="Luben">Robert Luben</name>
<affiliation><nlm:aff id="aff100">Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name>
<affiliation><nlm:aff id="aff101">Department of Public Health and Primary Care, University of Cambridge, Cambridge CB2 1TN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Choi, Ji Yeob" sort="Choi, Ji Yeob" uniqKey="Choi J" first="Ji-Yeob" last="Choi">Ji-Yeob Choi</name>
<affiliation><nlm:aff id="aff102">Department of Biomedical Science, Seoul National University College of Medicine, Seoul 110-799, Korea</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff103">Department of Surgery, Seoul National University College of Medicine, Seoul 110-799, Korea</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kang, Daehee" sort="Kang, Daehee" uniqKey="Kang D" first="Daehee" last="Kang">Daehee Kang</name>
<affiliation><nlm:aff id="aff102">Department of Biomedical Science, Seoul National University College of Medicine, Seoul 110-799, Korea</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff103">Department of Surgery, Seoul National University College of Medicine, Seoul 110-799, Korea</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff104">Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hartman, Mikael" sort="Hartman, Mikael" uniqKey="Hartman M" first="Mikael" last="Hartman">Mikael Hartman</name>
<affiliation><nlm:aff id="aff105">Saw Swee Hock School of Public Health, National University of Singapore and Department of Surgery, National University Health System, Singapore 117597, Singapore</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lim, Wei Yen" sort="Lim, Wei Yen" uniqKey="Lim W" first="Wei Yen" last="Lim">Wei Yen Lim</name>
<affiliation><nlm:aff id="aff105">Saw Swee Hock School of Public Health, National University of Singapore and Department of Surgery, National University Health System, Singapore 117597, Singapore</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff106">Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore 119228, Singapore</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kabisch, Maria" sort="Kabisch, Maria" uniqKey="Kabisch M" first="Maria" last="Kabisch">Maria Kabisch</name>
<affiliation><nlm:aff id="aff47">Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name>
<affiliation><nlm:aff id="aff47">Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff107">Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota 12362, Columbia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name>
<affiliation><nlm:aff id="aff108">Department of Genetics and Pathology, Pomeranian Medical University, 70-115 Szczecin, Poland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name>
<affiliation><nlm:aff id="aff108">Department of Genetics and Pathology, Pomeranian Medical University, 70-115 Szczecin, Poland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mckay, James" sort="Mckay, James" uniqKey="Mckay J" first="James" last="Mckay">James Mckay</name>
<affiliation><nlm:aff id="aff109">International Agency for Research on Cancer, 69372 Lyon, CEDEX 08, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sangrajrang, Suleeporn" sort="Sangrajrang, Suleeporn" uniqKey="Sangrajrang S" first="Suleeporn" last="Sangrajrang">Suleeporn Sangrajrang</name>
<affiliation><nlm:aff id="aff110">National Cancer Institute, Bangkok 10400, Thailand</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name>
<affiliation><nlm:aff id="aff111">Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name>
<affiliation><nlm:aff id="aff112">Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research “Demokritos,” Aghia Paraskevi Attikis, 153 10 Athens, Greece</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name>
<affiliation><nlm:aff id="aff113">Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff114">School of Public Health, China Medical University, Taichung 40402, Taiwan</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yu, Jyh Cherng" sort="Yu, Jyh Cherng" uniqKey="Yu J" first="Jyh-Cherng" last="Yu">Jyh-Cherng Yu</name>
<affiliation><nlm:aff id="aff115">Department of Surgery, Tri-Service General Hospital, Taipei 114, Taiwan</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name>
<affiliation><nlm:aff id="aff34">Department of Epidemiology, University of California Irvine, Irvine, CA 92697, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schoemaker, Minouk J" sort="Schoemaker, Minouk J" uniqKey="Schoemaker M" first="Minouk J." last="Schoemaker">Minouk J. Schoemaker</name>
<affiliation><nlm:aff id="aff92">Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton SM2 5NG, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name>
<affiliation><nlm:aff id="aff92">Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton SM2 5NG, UK</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff116">Division of Breast Cancer Research, Institute of Cancer Research, Sutton SM2 5NG, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Borresen Dale, Anne Lise" sort="Borresen Dale, Anne Lise" uniqKey="Borresen Dale A" first="Anne-Lise" last="Borresen-Dale">Anne-Lise Borresen-Dale</name>
<affiliation><nlm:aff id="aff4">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, 0310 Oslo, Norway</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff117">Institute of Clinical Medicine, University of Oslo (UiO), Oslo 0316, Norway</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name>
<affiliation><nlm:aff id="aff4">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, 0310 Oslo, Norway</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff117">Institute of Clinical Medicine, University of Oslo (UiO), Oslo 0316, Norway</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff118">Department of Clinical Molecular Biology (EpiGen), University of Oslo (UiO), Oslo 0316, Norway</nlm:aff>
</affiliation>
</author>
<author><name sortKey="French, Juliet D" sort="French, Juliet D" uniqKey="French J" first="Juliet D." last="French">Juliet D. French</name>
<affiliation><nlm:aff id="aff2">Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Edwards, Stacey L" sort="Edwards, Stacey L" uniqKey="Edwards S" first="Stacey L." last="Edwards">Stacey L. Edwards</name>
<affiliation><nlm:aff id="aff2">Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name>
<affiliation><nlm:aff id="aff6">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name>
<affiliation><nlm:aff id="aff3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff6">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name>
<affiliation><nlm:aff id="aff1">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
<affiliation><nlm:aff id="aff2">Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26073781</idno>
<idno type="pmc">4572510</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572510</idno>
<idno type="RBID">PMC:4572510</idno>
<idno type="doi">10.1016/j.ajhg.2015.05.002</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">001689</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001689</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate <italic>NRBF2</italic>
Expression</title>
<author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name>
<affiliation><nlm:aff id="aff1">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff>
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<author><name sortKey="Mccue, Karen" sort="Mccue, Karen" uniqKey="Mccue K" first="Karen" last="Mccue">Karen Mccue</name>
<affiliation><nlm:aff id="aff2">Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia</nlm:aff>
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<author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name>
<affiliation><nlm:aff id="aff2">Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia</nlm:aff>
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<author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name>
<affiliation><nlm:aff id="aff3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff>
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<affiliation><nlm:aff id="aff4">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, 0310 Oslo, Norway</nlm:aff>
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<affiliation><nlm:aff id="aff5">K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Kirkeveien 166, 0450 Oslo, Norway</nlm:aff>
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<affiliation><nlm:aff id="aff6">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff>
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<author><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name>
<affiliation><nlm:aff id="aff1">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff>
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<author><name sortKey="Thompson, Deborah" sort="Thompson, Deborah" uniqKey="Thompson D" first="Deborah" last="Thompson">Deborah Thompson</name>
<affiliation><nlm:aff id="aff3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff>
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<affiliation><nlm:aff id="aff6">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff>
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<affiliation><nlm:aff id="aff3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff>
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<affiliation><nlm:aff id="aff3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff>
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<affiliation><nlm:aff id="aff3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff>
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<affiliation><nlm:aff id="aff7">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</nlm:aff>
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<author><name sortKey="Scott, Christopher G" sort="Scott, Christopher G" uniqKey="Scott C" first="Christopher G." last="Scott">Christopher G. Scott</name>
<affiliation><nlm:aff id="aff8">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff>
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<author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name>
<affiliation><nlm:aff id="aff9">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff>
</affiliation>
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<author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name>
<affiliation><nlm:aff id="aff9">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff>
</affiliation>
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<author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name>
<affiliation><nlm:aff id="aff10">Department of Pathology, The University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff>
</affiliation>
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<author><name sortKey="Stone, Jennifer" sort="Stone, Jennifer" uniqKey="Stone J" first="Jennifer" last="Stone">Jennifer Stone</name>
<affiliation><nlm:aff id="aff11">Centre for Genetic Origins of Health and Disease, University of Western Australia, Crawley, WA 6009, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name>
<affiliation><nlm:aff id="aff7">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</nlm:aff>
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<author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name>
<affiliation><nlm:aff id="aff7">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J." last="Scott">Rodney J. Scott</name>
<affiliation><nlm:aff id="aff12">Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Newcastle, NSW 2308, Australia</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff13">Division of Molecular Medicine, Pathology North, John Hunter Hospital and The Hunter Medical Research Institute, Newcastle, NSW 2305, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name>
<affiliation><nlm:aff id="aff14">Division of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name>
<affiliation><nlm:aff id="aff14">Division of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff15">Institute of Population Health, University of Manchester, Manchester M13 9PL, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name>
<affiliation><nlm:aff id="aff16">University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name>
<affiliation><nlm:aff id="aff17">Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name>
<affiliation><nlm:aff id="aff16">University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff18">Department of Medicine Division of Hematology and Oncology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Heusinger, Katharina" sort="Heusinger, Katharina" uniqKey="Heusinger K" first="Katharina" last="Heusinger">Katharina Heusinger</name>
<affiliation><nlm:aff id="aff16">University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name>
<affiliation><nlm:aff id="aff19">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name>
<affiliation><nlm:aff id="aff19">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name>
<affiliation><nlm:aff id="aff20">Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford OX3 7BN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name>
<affiliation><nlm:aff id="aff21">Research Oncology, Division of Cancer Studies, King’s College London, Guy’s Hospital, London SE1 9RT, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name>
<affiliation><nlm:aff id="aff22">National Center for Tumor Diseases, University of Heidelberg, 69120 Heidelberg, Germany</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff23">Division of Molecular Genetic Epidemiology, German Cancer Research Centre (DZFK), 69047 Heidelberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name>
<affiliation><nlm:aff id="aff22">National Center for Tumor Diseases, University of Heidelberg, 69120 Heidelberg, Germany</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff24">Department of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name>
<affiliation><nlm:aff id="aff25">University Paris-Sud, UMRS 1018, 94807 Villejuif, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff26">INSERM (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 94807 Villejuif, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name>
<affiliation><nlm:aff id="aff25">University Paris-Sud, UMRS 1018, 94807 Villejuif, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff26">INSERM (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 94807 Villejuif, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name>
<affiliation><nlm:aff id="aff27">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff28">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff29">Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name>
<affiliation><nlm:aff id="aff30">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name>
<affiliation><nlm:aff id="aff31">Human Genotyping (CEGEN) Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff32">Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid 28029, Spain</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff33">Biomedical Network on Rare Diseases (CIBERER), Madrid 28029, Spain</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name>
<affiliation><nlm:aff id="aff31">Human Genotyping (CEGEN) Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name>
<affiliation><nlm:aff id="aff34">Department of Epidemiology, University of California Irvine, Irvine, CA 92697, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name>
<affiliation><nlm:aff id="aff35">Beckman Research Institute of City of Hope, Duarte, CA 91010, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name>
<affiliation><nlm:aff id="aff36">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name>
<affiliation><nlm:aff id="aff36">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff37">Division of Preventive Oncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff38">German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Engel, Christoph" sort="Engel, Christoph" uniqKey="Engel C" first="Christoph" last="Engel">Christoph Engel</name>
<affiliation><nlm:aff id="aff39">Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04107 Leipzig, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name>
<affiliation><nlm:aff id="aff40">Division of Gynaecology and Obstetrics, Technische Universität München, 81675 Munich, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name>
<affiliation><nlm:aff id="aff41">Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne 50932, Germany</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff42">Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, Cologne 50937, Germany</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff43">Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne 50937, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Arnold, Norbert" sort="Arnold, Norbert" uniqKey="Arnold N" first="Norbert" last="Arnold">Norbert Arnold</name>
<affiliation><nlm:aff id="aff44">Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, 24105 Kiel, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name>
<affiliation><nlm:aff id="aff38">German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff45">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff46">University of Tübingen, 72074 Tübingen, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name>
<affiliation><nlm:aff id="aff47">Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name>
<affiliation><nlm:aff id="aff48">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Khan, Sofia" sort="Khan, Sofia" uniqKey="Khan S" first="Sofia" last="Khan">Sofia Khan</name>
<affiliation><nlm:aff id="aff49">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, 00029 HUS, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name>
<affiliation><nlm:aff id="aff49">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, 00029 HUS, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ito, Hidemi" sort="Ito, Hidemi" uniqKey="Ito H" first="Hidemi" last="Ito">Hidemi Ito</name>
<affiliation><nlm:aff id="aff50">Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi 464-8681, Japan</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Matsuo, Keitaro" sort="Matsuo, Keitaro" uniqKey="Matsuo K" first="Keitaro" last="Matsuo">Keitaro Matsuo</name>
<affiliation><nlm:aff id="aff51">Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka 812-8582, Japan</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name>
<affiliation><nlm:aff id="aff52">Department of Radiation Oncology, Hannover Medical School, 30625 Hannover, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name>
<affiliation><nlm:aff id="aff53">Gynaecology Research Unit, Hannover Medical School, 30625 Hannover, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name>
<affiliation><nlm:aff id="aff54">Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name>
<affiliation><nlm:aff id="aff55">Department of Oncology - Pathology, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name>
<affiliation><nlm:aff id="aff56">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio 70211, Finland</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff57">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio 70211, Finland</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff58">Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio 70211, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name>
<affiliation><nlm:aff id="aff56">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio 70211, Finland</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff57">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio 70211, Finland</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff58">Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio 70211, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tseng, Chiu Chen" sort="Tseng, Chiu Chen" uniqKey="Tseng C" first="Chiu-Chen" last="Tseng">Chiu-Chen Tseng</name>
<affiliation><nlm:aff id="aff59">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wu, Anna H" sort="Wu, Anna H" uniqKey="Wu A" first="Anna H." last="Wu">Anna H. Wu</name>
<affiliation><nlm:aff id="aff59">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Floris, Giuseppe" sort="Floris, Giuseppe" uniqKey="Floris G" first="Giuseppe" last="Floris">Giuseppe Floris</name>
<affiliation><nlm:aff id="aff60">University Hospital Gashuisberg, 3000 Leuven, Belgium</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name>
<affiliation><nlm:aff id="aff61">Vesalius Research Center (VRC), VIB, Leuven 3000, Belgium</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff62">Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven 3000, Belgium</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name>
<affiliation><nlm:aff id="aff48">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name>
<affiliation><nlm:aff id="aff63">IFOM, the FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, 20139 Milan, Italy</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name>
<affiliation><nlm:aff id="aff64">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), 20133 Milan, Italy</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name>
<affiliation><nlm:aff id="aff65">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name>
<affiliation><nlm:aff id="aff8">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
<affiliation><nlm:aff id="aff9">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff66">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3053, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name>
<affiliation><nlm:aff id="aff67">Anatomical Pathology, The Alfred Hospital, Melbourne, VIC 3004, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name>
<affiliation><nlm:aff id="aff9">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff66">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3053, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dugue, Pierre Antoine" sort="Dugue, Pierre Antoine" uniqKey="Dugue P" first="Pierre-Antoine" last="Dugué">Pierre-Antoine Dugué</name>
<affiliation><nlm:aff id="aff66">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3053, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name>
<affiliation><nlm:aff id="aff59">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Maskarinec, Gertraud" sort="Maskarinec, Gertraud" uniqKey="Maskarinec G" first="Gertraud" last="Maskarinec">Gertraud Maskarinec</name>
<affiliation><nlm:aff id="aff68">Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Woolcott, Christy" sort="Woolcott, Christy" uniqKey="Woolcott C" first="Christy" last="Woolcott">Christy Woolcott</name>
<affiliation><nlm:aff id="aff69">Departments of Obstetrics & Gynaecology and Pediatrics, Dalhousie University, Halifax, NS B3H 4R2, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name>
<affiliation><nlm:aff id="aff59">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Goldberg, Mark S" sort="Goldberg, Mark S" uniqKey="Goldberg M" first="Mark S." last="Goldberg">Mark S. Goldberg</name>
<affiliation><nlm:aff id="aff70">Department of Medicine, McGill University, Montreal, QC H3A 1W7, Canada</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff71">Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, Montreal, QC H3H 2R9, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name>
<affiliation><nlm:aff id="aff72">Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City, QC G1V 4G2, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Teo, Soo H" sort="Teo, Soo H" uniqKey="Teo S" first="Soo H." last="Teo">Soo H. Teo</name>
<affiliation><nlm:aff id="aff73">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre (UMMC), 50603 Kuala Lumpur, Malaysia</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff74">Cancer Research Initiatives Foundation, Sime Darby Medical Centre, 47500 Subang Jaya, Malaysia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mariapun, Shivaani" sort="Mariapun, Shivaani" uniqKey="Mariapun S" first="Shivaani" last="Mariapun">Shivaani Mariapun</name>
<affiliation><nlm:aff id="aff73">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre (UMMC), 50603 Kuala Lumpur, Malaysia</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff74">Cancer Research Initiatives Foundation, Sime Darby Medical Centre, 47500 Subang Jaya, Malaysia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Helland, Slaug" sort="Helland, Slaug" uniqKey="Helland " first=" Slaug" last="Helland"> Slaug Helland</name>
<affiliation><nlm:aff id="aff75">Department of Oncology, Oslo University Hospital, Radiumhospitalet, 0310 Oslo, Norway</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Haakensen, Vilde" sort="Haakensen, Vilde" uniqKey="Haakensen V" first="Vilde" last="Haakensen">Vilde Haakensen</name>
<affiliation><nlm:aff id="aff76">Department of Genetics, Oslo University Hospital, Radiumhospitalet, 0310 Oslo, Norway</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name>
<affiliation><nlm:aff id="aff77">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Beeghly Fadiel, Alicia" sort="Beeghly Fadiel, Alicia" uniqKey="Beeghly Fadiel A" first="Alicia" last="Beeghly-Fadiel">Alicia Beeghly-Fadiel</name>
<affiliation><nlm:aff id="aff77">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tamimi, Rulla" sort="Tamimi, Rulla" uniqKey="Tamimi R" first="Rulla" last="Tamimi">Rulla Tamimi</name>
<affiliation><nlm:aff id="aff78">Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff79">Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff80">Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name>
<affiliation><nlm:aff id="aff81">Department of Oncology, Oulu University Hospital and University of Oulu, 90014 Oulu, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name>
<affiliation><nlm:aff id="aff82">Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, 90014 Oulu, Finland</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff83">Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, 90220 Oulu, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name>
<affiliation><nlm:aff id="aff84">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff85">Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 3G3, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name>
<affiliation><nlm:aff id="aff86">Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff87">Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5S 3G3, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name>
<affiliation><nlm:aff id="aff88">Department of Human Genetics, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff89">Department of Pathology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tollenaar, Robert A E M" sort="Tollenaar, Robert A E M" uniqKey="Tollenaar R" first="Robert A. E. M." last="Tollenaar">Robert A. E. M. Tollenaar</name>
<affiliation><nlm:aff id="aff90">Department of Surgical Oncology, Leiden University Medical Center, 2333 ZC Leiden, the Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name>
<affiliation><nlm:aff id="aff91">Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20850, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name>
<affiliation><nlm:aff id="aff92">Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton SM2 5NG, UK</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff93">Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, London SW3 6JB, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name>
<affiliation><nlm:aff id="aff1">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name>
<affiliation><nlm:aff id="aff94">Department of Medical Oncology, Erasmus MC Cancer Institute, 3008 AE Rotterdam, the Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tilanus Linthorst, Madeleine" sort="Tilanus Linthorst, Madeleine" uniqKey="Tilanus Linthorst M" first="Madeleine" last="Tilanus-Linthorst">Madeleine Tilanus-Linthorst</name>
<affiliation><nlm:aff id="aff95">Department of Surgical Oncology, Erasmus University Medical Center, 3075 EA Rotterdam, the Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name>
<affiliation><nlm:aff id="aff96">Human Genetics Division, Genome Institute of Singapore, Singapore 138672, Singapore</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gao, Yu Tang" sort="Gao, Yu Tang" uniqKey="Gao Y" first="Yu-Tang" last="Gao">Yu-Tang Gao</name>
<affiliation><nlm:aff id="aff97">Department of Epidemiology, Shanghai Cancer Institute, Xuhui, Shanghai 200031, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name>
<affiliation><nlm:aff id="aff77">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name>
<affiliation><nlm:aff id="aff98">Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield S10 2RX, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name>
<affiliation><nlm:aff id="aff99">Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Luben, Robert" sort="Luben, Robert" uniqKey="Luben R" first="Robert" last="Luben">Robert Luben</name>
<affiliation><nlm:aff id="aff100">Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name>
<affiliation><nlm:aff id="aff101">Department of Public Health and Primary Care, University of Cambridge, Cambridge CB2 1TN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Choi, Ji Yeob" sort="Choi, Ji Yeob" uniqKey="Choi J" first="Ji-Yeob" last="Choi">Ji-Yeob Choi</name>
<affiliation><nlm:aff id="aff102">Department of Biomedical Science, Seoul National University College of Medicine, Seoul 110-799, Korea</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff103">Department of Surgery, Seoul National University College of Medicine, Seoul 110-799, Korea</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kang, Daehee" sort="Kang, Daehee" uniqKey="Kang D" first="Daehee" last="Kang">Daehee Kang</name>
<affiliation><nlm:aff id="aff102">Department of Biomedical Science, Seoul National University College of Medicine, Seoul 110-799, Korea</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff103">Department of Surgery, Seoul National University College of Medicine, Seoul 110-799, Korea</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff104">Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hartman, Mikael" sort="Hartman, Mikael" uniqKey="Hartman M" first="Mikael" last="Hartman">Mikael Hartman</name>
<affiliation><nlm:aff id="aff105">Saw Swee Hock School of Public Health, National University of Singapore and Department of Surgery, National University Health System, Singapore 117597, Singapore</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lim, Wei Yen" sort="Lim, Wei Yen" uniqKey="Lim W" first="Wei Yen" last="Lim">Wei Yen Lim</name>
<affiliation><nlm:aff id="aff105">Saw Swee Hock School of Public Health, National University of Singapore and Department of Surgery, National University Health System, Singapore 117597, Singapore</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff106">Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore 119228, Singapore</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kabisch, Maria" sort="Kabisch, Maria" uniqKey="Kabisch M" first="Maria" last="Kabisch">Maria Kabisch</name>
<affiliation><nlm:aff id="aff47">Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name>
<affiliation><nlm:aff id="aff47">Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff107">Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota 12362, Columbia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name>
<affiliation><nlm:aff id="aff108">Department of Genetics and Pathology, Pomeranian Medical University, 70-115 Szczecin, Poland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name>
<affiliation><nlm:aff id="aff108">Department of Genetics and Pathology, Pomeranian Medical University, 70-115 Szczecin, Poland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mckay, James" sort="Mckay, James" uniqKey="Mckay J" first="James" last="Mckay">James Mckay</name>
<affiliation><nlm:aff id="aff109">International Agency for Research on Cancer, 69372 Lyon, CEDEX 08, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sangrajrang, Suleeporn" sort="Sangrajrang, Suleeporn" uniqKey="Sangrajrang S" first="Suleeporn" last="Sangrajrang">Suleeporn Sangrajrang</name>
<affiliation><nlm:aff id="aff110">National Cancer Institute, Bangkok 10400, Thailand</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name>
<affiliation><nlm:aff id="aff111">Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name>
<affiliation><nlm:aff id="aff112">Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research “Demokritos,” Aghia Paraskevi Attikis, 153 10 Athens, Greece</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name>
<affiliation><nlm:aff id="aff113">Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff114">School of Public Health, China Medical University, Taichung 40402, Taiwan</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yu, Jyh Cherng" sort="Yu, Jyh Cherng" uniqKey="Yu J" first="Jyh-Cherng" last="Yu">Jyh-Cherng Yu</name>
<affiliation><nlm:aff id="aff115">Department of Surgery, Tri-Service General Hospital, Taipei 114, Taiwan</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name>
<affiliation><nlm:aff id="aff34">Department of Epidemiology, University of California Irvine, Irvine, CA 92697, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schoemaker, Minouk J" sort="Schoemaker, Minouk J" uniqKey="Schoemaker M" first="Minouk J." last="Schoemaker">Minouk J. Schoemaker</name>
<affiliation><nlm:aff id="aff92">Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton SM2 5NG, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name>
<affiliation><nlm:aff id="aff92">Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton SM2 5NG, UK</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff116">Division of Breast Cancer Research, Institute of Cancer Research, Sutton SM2 5NG, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Borresen Dale, Anne Lise" sort="Borresen Dale, Anne Lise" uniqKey="Borresen Dale A" first="Anne-Lise" last="Borresen-Dale">Anne-Lise Borresen-Dale</name>
<affiliation><nlm:aff id="aff4">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, 0310 Oslo, Norway</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff117">Institute of Clinical Medicine, University of Oslo (UiO), Oslo 0316, Norway</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name>
<affiliation><nlm:aff id="aff4">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, 0310 Oslo, Norway</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff117">Institute of Clinical Medicine, University of Oslo (UiO), Oslo 0316, Norway</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff118">Department of Clinical Molecular Biology (EpiGen), University of Oslo (UiO), Oslo 0316, Norway</nlm:aff>
</affiliation>
</author>
<author><name sortKey="French, Juliet D" sort="French, Juliet D" uniqKey="French J" first="Juliet D." last="French">Juliet D. French</name>
<affiliation><nlm:aff id="aff2">Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Edwards, Stacey L" sort="Edwards, Stacey L" uniqKey="Edwards S" first="Stacey L." last="Edwards">Stacey L. Edwards</name>
<affiliation><nlm:aff id="aff2">Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name>
<affiliation><nlm:aff id="aff6">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name>
<affiliation><nlm:aff id="aff3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff6">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name>
<affiliation><nlm:aff id="aff1">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
<affiliation><nlm:aff id="aff2">Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">American Journal of Human Genetics</title>
<idno type="ISSN">0002-9297</idno>
<idno type="eISSN">1537-6605</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Genome-wide association studies have identified SNPs near <italic>ZNF365</italic>
at 10q21.2 that are associated with both breast cancer risk and mammographic density. To identify the most likely causal SNPs, we fine mapped the association signal by genotyping 428 SNPs across the region in 89,050 European and 12,893 Asian case and control subjects from the Breast Cancer Association Consortium. We identified four independent sets of correlated, highly trait-associated variants (iCHAVs), three of which were located within <italic>ZNF365</italic>
. The most strongly risk-associated SNP, rs10995201 in iCHAV1, showed clear evidence of association with both estrogen receptor (ER)-positive (OR = 0.85 [0.82–0.88]) and ER-negative (OR = 0.87 [0.82–0.91]) disease, and was also the SNP most strongly associated with percent mammographic density. iCHAV2 (lead SNP, chr10: 64,258,684:D) and iCHAV3 (lead SNP, rs7922449) were also associated with ER-positive (OR = 0.93 [0.91–0.95] and OR = 1.06 [1.03–1.09]) and ER-negative (OR = 0.95 [0.91–0.98] and OR = 1.08 [1.04–1.13]) disease. There was weaker evidence for iCHAV4, located 5′ of <italic>ADO</italic>
, associated only with ER-positive breast cancer (OR = 0.93 [0.90–0.96]). We found 12, 17, 18, and 2 candidate causal SNPs for breast cancer in iCHAVs 1–4, respectively. Chromosome conformation capture analysis showed that iCHAV2 interacts with the <italic>ZNF365</italic>
and <italic>NRBF2</italic>
(more than 600 kb away) promoters in normal and cancerous breast epithelial cells. Luciferase assays did not identify SNPs that affect transactivation of <italic>ZNF365,</italic>
but identified a protective haplotype in iCHAV2, associated with silencing of the <italic>NRBF2</italic>
promoter, implicating this gene in the etiology of breast cancer.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Hum Genet</journal-id>
<journal-id journal-id-type="iso-abbrev">Am. J. Hum. Genet</journal-id>
<journal-title-group><journal-title>American Journal of Human Genetics</journal-title>
</journal-title-group>
<issn pub-type="ppub">0002-9297</issn>
<issn pub-type="epub">1537-6605</issn>
<publisher><publisher-name>Elsevier</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26073781</article-id>
<article-id pub-id-type="pmc">4572510</article-id>
<article-id pub-id-type="publisher-id">S0002-9297(15)00187-1</article-id>
<article-id pub-id-type="doi">10.1016/j.ajhg.2015.05.002</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate <italic>NRBF2</italic>
Expression</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Darabi</surname>
<given-names>Hatef</given-names>
</name>
<xref rid="aff1" ref-type="aff">1</xref>
<xref rid="fn1" ref-type="fn">119</xref>
</contrib>
<contrib contrib-type="author"><name><surname>McCue</surname>
<given-names>Karen</given-names>
</name>
<xref rid="aff2" ref-type="aff">2</xref>
<xref rid="fn1" ref-type="fn">119</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Beesley</surname>
<given-names>Jonathan</given-names>
</name>
<xref rid="aff2" ref-type="aff">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Michailidou</surname>
<given-names>Kyriaki</given-names>
</name>
<xref rid="aff3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nord</surname>
<given-names>Silje</given-names>
</name>
<xref rid="aff4" ref-type="aff">4</xref>
<xref rid="aff5" ref-type="aff">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kar</surname>
<given-names>Siddhartha</given-names>
</name>
<xref rid="aff6" ref-type="aff">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Humphreys</surname>
<given-names>Keith</given-names>
</name>
<xref rid="aff1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Thompson</surname>
<given-names>Deborah</given-names>
</name>
<xref rid="aff3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ghoussaini</surname>
<given-names>Maya</given-names>
</name>
<xref rid="aff6" ref-type="aff">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bolla</surname>
<given-names>Manjeet K.</given-names>
</name>
<xref rid="aff3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dennis</surname>
<given-names>Joe</given-names>
</name>
<xref rid="aff3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Qin</given-names>
</name>
<xref rid="aff3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Canisius</surname>
<given-names>Sander</given-names>
</name>
<xref rid="aff7" ref-type="aff">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Scott</surname>
<given-names>Christopher G.</given-names>
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<xref rid="aff8" ref-type="aff">8</xref>
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<given-names>Carmel</given-names>
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<xref rid="aff9" ref-type="aff">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hopper</surname>
<given-names>John L.</given-names>
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<xref rid="aff9" ref-type="aff">9</xref>
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<given-names>Melissa C.</given-names>
</name>
<xref rid="aff10" ref-type="aff">10</xref>
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<given-names>Jennifer</given-names>
</name>
<xref rid="aff11" ref-type="aff">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Broeks</surname>
<given-names>Annegien</given-names>
</name>
<xref rid="aff7" ref-type="aff">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schmidt</surname>
<given-names>Marjanka K.</given-names>
</name>
<xref rid="aff7" ref-type="aff">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Scott</surname>
<given-names>Rodney J.</given-names>
</name>
<xref rid="aff12" ref-type="aff">12</xref>
<xref rid="aff13" ref-type="aff">13</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lophatananon</surname>
<given-names>Artitaya</given-names>
</name>
<xref rid="aff14" ref-type="aff">14</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Muir</surname>
<given-names>Kenneth</given-names>
</name>
<xref rid="aff14" ref-type="aff">14</xref>
<xref rid="aff15" ref-type="aff">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Beckmann</surname>
<given-names>Matthias W.</given-names>
</name>
<xref rid="aff16" ref-type="aff">16</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ekici</surname>
<given-names>Arif B.</given-names>
</name>
<xref rid="aff17" ref-type="aff">17</xref>
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<contrib contrib-type="author"><name><surname>Fasching</surname>
<given-names>Peter A.</given-names>
</name>
<xref rid="aff16" ref-type="aff">16</xref>
<xref rid="aff18" ref-type="aff">18</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Heusinger</surname>
<given-names>Katharina</given-names>
</name>
<xref rid="aff16" ref-type="aff">16</xref>
</contrib>
<contrib contrib-type="author"><name><surname>dos-Santos-Silva</surname>
<given-names>Isabel</given-names>
</name>
<xref rid="aff19" ref-type="aff">19</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Peto</surname>
<given-names>Julian</given-names>
</name>
<xref rid="aff19" ref-type="aff">19</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tomlinson</surname>
<given-names>Ian</given-names>
</name>
<xref rid="aff20" ref-type="aff">20</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sawyer</surname>
<given-names>Elinor J.</given-names>
</name>
<xref rid="aff21" ref-type="aff">21</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Burwinkel</surname>
<given-names>Barbara</given-names>
</name>
<xref rid="aff22" ref-type="aff">22</xref>
<xref rid="aff23" ref-type="aff">23</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Marme</surname>
<given-names>Frederik</given-names>
</name>
<xref rid="aff22" ref-type="aff">22</xref>
<xref rid="aff24" ref-type="aff">24</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Guénel</surname>
<given-names>Pascal</given-names>
</name>
<xref rid="aff25" ref-type="aff">25</xref>
<xref rid="aff26" ref-type="aff">26</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Truong</surname>
<given-names>Thérèse</given-names>
</name>
<xref rid="aff25" ref-type="aff">25</xref>
<xref rid="aff26" ref-type="aff">26</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bojesen</surname>
<given-names>Stig E.</given-names>
</name>
<xref rid="aff27" ref-type="aff">27</xref>
<xref rid="aff28" ref-type="aff">28</xref>
<xref rid="aff29" ref-type="aff">29</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Flyger</surname>
<given-names>Henrik</given-names>
</name>
<xref rid="aff30" ref-type="aff">30</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Benitez</surname>
<given-names>Javier</given-names>
</name>
<xref rid="aff31" ref-type="aff">31</xref>
<xref rid="aff32" ref-type="aff">32</xref>
<xref rid="aff33" ref-type="aff">33</xref>
</contrib>
<contrib contrib-type="author"><name><surname>González-Neira</surname>
<given-names>Anna</given-names>
</name>
<xref rid="aff31" ref-type="aff">31</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Anton-Culver</surname>
<given-names>Hoda</given-names>
</name>
<xref rid="aff34" ref-type="aff">34</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Neuhausen</surname>
<given-names>Susan L.</given-names>
</name>
<xref rid="aff35" ref-type="aff">35</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Arndt</surname>
<given-names>Volker</given-names>
</name>
<xref rid="aff36" ref-type="aff">36</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Brenner</surname>
<given-names>Hermann</given-names>
</name>
<xref rid="aff36" ref-type="aff">36</xref>
<xref rid="aff37" ref-type="aff">37</xref>
<xref rid="aff38" ref-type="aff">38</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Engel</surname>
<given-names>Christoph</given-names>
</name>
<xref rid="aff39" ref-type="aff">39</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Meindl</surname>
<given-names>Alfons</given-names>
</name>
<xref rid="aff40" ref-type="aff">40</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schmutzler</surname>
<given-names>Rita K.</given-names>
</name>
<xref rid="aff41" ref-type="aff">41</xref>
<xref rid="aff42" ref-type="aff">42</xref>
<xref rid="aff43" ref-type="aff">43</xref>
</contrib>
<contrib contrib-type="author"><collab>German Consortium of Hereditary Breast and Ovarian Cancer</collab>
</contrib>
<contrib contrib-type="author"><name><surname>Arnold</surname>
<given-names>Norbert</given-names>
</name>
<xref rid="aff44" ref-type="aff">44</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Brauch</surname>
<given-names>Hiltrud</given-names>
</name>
<xref rid="aff38" ref-type="aff">38</xref>
<xref rid="aff45" ref-type="aff">45</xref>
<xref rid="aff46" ref-type="aff">46</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hamann</surname>
<given-names>Ute</given-names>
</name>
<xref rid="aff47" ref-type="aff">47</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chang-Claude</surname>
<given-names>Jenny</given-names>
</name>
<xref rid="aff48" ref-type="aff">48</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Khan</surname>
<given-names>Sofia</given-names>
</name>
<xref rid="aff49" ref-type="aff">49</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nevanlinna</surname>
<given-names>Heli</given-names>
</name>
<xref rid="aff49" ref-type="aff">49</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ito</surname>
<given-names>Hidemi</given-names>
</name>
<xref rid="aff50" ref-type="aff">50</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Matsuo</surname>
<given-names>Keitaro</given-names>
</name>
<xref rid="aff51" ref-type="aff">51</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bogdanova</surname>
<given-names>Natalia V.</given-names>
</name>
<xref rid="aff52" ref-type="aff">52</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dörk</surname>
<given-names>Thilo</given-names>
</name>
<xref rid="aff53" ref-type="aff">53</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lindblom</surname>
<given-names>Annika</given-names>
</name>
<xref rid="aff54" ref-type="aff">54</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Margolin</surname>
<given-names>Sara</given-names>
</name>
<xref rid="aff55" ref-type="aff">55</xref>
</contrib>
<contrib contrib-type="author"><collab>kConFab/AOCS Investigators</collab>
</contrib>
<contrib contrib-type="author"><name><surname>Kosma</surname>
<given-names>Veli-Matti</given-names>
</name>
<xref rid="aff56" ref-type="aff">56</xref>
<xref rid="aff57" ref-type="aff">57</xref>
<xref rid="aff58" ref-type="aff">58</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mannermaa</surname>
<given-names>Arto</given-names>
</name>
<xref rid="aff56" ref-type="aff">56</xref>
<xref rid="aff57" ref-type="aff">57</xref>
<xref rid="aff58" ref-type="aff">58</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tseng</surname>
<given-names>Chiu-chen</given-names>
</name>
<xref rid="aff59" ref-type="aff">59</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wu</surname>
<given-names>Anna H.</given-names>
</name>
<xref rid="aff59" ref-type="aff">59</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Floris</surname>
<given-names>Giuseppe</given-names>
</name>
<xref rid="aff60" ref-type="aff">60</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lambrechts</surname>
<given-names>Diether</given-names>
</name>
<xref rid="aff61" ref-type="aff">61</xref>
<xref rid="aff62" ref-type="aff">62</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rudolph</surname>
<given-names>Anja</given-names>
</name>
<xref rid="aff48" ref-type="aff">48</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Peterlongo</surname>
<given-names>Paolo</given-names>
</name>
<xref rid="aff63" ref-type="aff">63</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Radice</surname>
<given-names>Paolo</given-names>
</name>
<xref rid="aff64" ref-type="aff">64</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Couch</surname>
<given-names>Fergus J.</given-names>
</name>
<xref rid="aff65" ref-type="aff">65</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vachon</surname>
<given-names>Celine</given-names>
</name>
<xref rid="aff8" ref-type="aff">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Giles</surname>
<given-names>Graham G.</given-names>
</name>
<xref rid="aff9" ref-type="aff">9</xref>
<xref rid="aff66" ref-type="aff">66</xref>
</contrib>
<contrib contrib-type="author"><name><surname>McLean</surname>
<given-names>Catriona</given-names>
</name>
<xref rid="aff67" ref-type="aff">67</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Milne</surname>
<given-names>Roger L.</given-names>
</name>
<xref rid="aff9" ref-type="aff">9</xref>
<xref rid="aff66" ref-type="aff">66</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dugué</surname>
<given-names>Pierre-Antoine</given-names>
</name>
<xref rid="aff66" ref-type="aff">66</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Haiman</surname>
<given-names>Christopher A.</given-names>
</name>
<xref rid="aff59" ref-type="aff">59</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Maskarinec</surname>
<given-names>Gertraud</given-names>
</name>
<xref rid="aff68" ref-type="aff">68</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Woolcott</surname>
<given-names>Christy</given-names>
</name>
<xref rid="aff69" ref-type="aff">69</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Henderson</surname>
<given-names>Brian E.</given-names>
</name>
<xref rid="aff59" ref-type="aff">59</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Goldberg</surname>
<given-names>Mark S.</given-names>
</name>
<xref rid="aff70" ref-type="aff">70</xref>
<xref rid="aff71" ref-type="aff">71</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Simard</surname>
<given-names>Jacques</given-names>
</name>
<xref rid="aff72" ref-type="aff">72</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Teo</surname>
<given-names>Soo H.</given-names>
</name>
<xref rid="aff73" ref-type="aff">73</xref>
<xref rid="aff74" ref-type="aff">74</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mariapun</surname>
<given-names>Shivaani</given-names>
</name>
<xref rid="aff73" ref-type="aff">73</xref>
<xref rid="aff74" ref-type="aff">74</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Helland</surname>
<given-names>Åslaug</given-names>
</name>
<xref rid="aff75" ref-type="aff">75</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Haakensen</surname>
<given-names>Vilde</given-names>
</name>
<xref rid="aff76" ref-type="aff">76</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zheng</surname>
<given-names>Wei</given-names>
</name>
<xref rid="aff77" ref-type="aff">77</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Beeghly-Fadiel</surname>
<given-names>Alicia</given-names>
</name>
<xref rid="aff77" ref-type="aff">77</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tamimi</surname>
<given-names>Rulla</given-names>
</name>
<xref rid="aff78" ref-type="aff">78</xref>
<xref rid="aff79" ref-type="aff">79</xref>
<xref rid="aff80" ref-type="aff">80</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jukkola-Vuorinen</surname>
<given-names>Arja</given-names>
</name>
<xref rid="aff81" ref-type="aff">81</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Winqvist</surname>
<given-names>Robert</given-names>
</name>
<xref rid="aff82" ref-type="aff">82</xref>
<xref rid="aff83" ref-type="aff">83</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Andrulis</surname>
<given-names>Irene L.</given-names>
</name>
<xref rid="aff84" ref-type="aff">84</xref>
<xref rid="aff85" ref-type="aff">85</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Knight</surname>
<given-names>Julia A.</given-names>
</name>
<xref rid="aff86" ref-type="aff">86</xref>
<xref rid="aff87" ref-type="aff">87</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Devilee</surname>
<given-names>Peter</given-names>
</name>
<xref rid="aff88" ref-type="aff">88</xref>
<xref rid="aff89" ref-type="aff">89</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tollenaar</surname>
<given-names>Robert A.E.M.</given-names>
</name>
<xref rid="aff90" ref-type="aff">90</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Figueroa</surname>
<given-names>Jonine</given-names>
</name>
<xref rid="aff91" ref-type="aff">91</xref>
</contrib>
<contrib contrib-type="author"><name><surname>García-Closas</surname>
<given-names>Montserrat</given-names>
</name>
<xref rid="aff92" ref-type="aff">92</xref>
<xref rid="aff93" ref-type="aff">93</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Czene</surname>
<given-names>Kamila</given-names>
</name>
<xref rid="aff1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hooning</surname>
<given-names>Maartje J.</given-names>
</name>
<xref rid="aff94" ref-type="aff">94</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tilanus-Linthorst</surname>
<given-names>Madeleine</given-names>
</name>
<xref rid="aff95" ref-type="aff">95</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Li</surname>
<given-names>Jingmei</given-names>
</name>
<xref rid="aff96" ref-type="aff">96</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gao</surname>
<given-names>Yu-Tang</given-names>
</name>
<xref rid="aff97" ref-type="aff">97</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shu</surname>
<given-names>Xiao-Ou</given-names>
</name>
<xref rid="aff77" ref-type="aff">77</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cox</surname>
<given-names>Angela</given-names>
</name>
<xref rid="aff98" ref-type="aff">98</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cross</surname>
<given-names>Simon S.</given-names>
</name>
<xref rid="aff99" ref-type="aff">99</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Luben</surname>
<given-names>Robert</given-names>
</name>
<xref rid="aff100" ref-type="aff">100</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Khaw</surname>
<given-names>Kay-Tee</given-names>
</name>
<xref rid="aff101" ref-type="aff">101</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Choi</surname>
<given-names>Ji-Yeob</given-names>
</name>
<xref rid="aff102" ref-type="aff">102</xref>
<xref rid="aff103" ref-type="aff">103</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kang</surname>
<given-names>Daehee</given-names>
</name>
<xref rid="aff102" ref-type="aff">102</xref>
<xref rid="aff103" ref-type="aff">103</xref>
<xref rid="aff104" ref-type="aff">104</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hartman</surname>
<given-names>Mikael</given-names>
</name>
<xref rid="aff105" ref-type="aff">105</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lim</surname>
<given-names>Wei Yen</given-names>
</name>
<xref rid="aff105" ref-type="aff">105</xref>
<xref rid="aff106" ref-type="aff">106</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kabisch</surname>
<given-names>Maria</given-names>
</name>
<xref rid="aff47" ref-type="aff">47</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Torres</surname>
<given-names>Diana</given-names>
</name>
<xref rid="aff47" ref-type="aff">47</xref>
<xref rid="aff107" ref-type="aff">107</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jakubowska</surname>
<given-names>Anna</given-names>
</name>
<xref rid="aff108" ref-type="aff">108</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lubinski</surname>
<given-names>Jan</given-names>
</name>
<xref rid="aff108" ref-type="aff">108</xref>
</contrib>
<contrib contrib-type="author"><name><surname>McKay</surname>
<given-names>James</given-names>
</name>
<xref rid="aff109" ref-type="aff">109</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sangrajrang</surname>
<given-names>Suleeporn</given-names>
</name>
<xref rid="aff110" ref-type="aff">110</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Toland</surname>
<given-names>Amanda E.</given-names>
</name>
<xref rid="aff111" ref-type="aff">111</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yannoukakos</surname>
<given-names>Drakoulis</given-names>
</name>
<xref rid="aff112" ref-type="aff">112</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shen</surname>
<given-names>Chen-Yang</given-names>
</name>
<xref rid="aff113" ref-type="aff">113</xref>
<xref rid="aff114" ref-type="aff">114</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yu</surname>
<given-names>Jyh-Cherng</given-names>
</name>
<xref rid="aff115" ref-type="aff">115</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ziogas</surname>
<given-names>Argyrios</given-names>
</name>
<xref rid="aff34" ref-type="aff">34</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schoemaker</surname>
<given-names>Minouk J.</given-names>
</name>
<xref rid="aff92" ref-type="aff">92</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Swerdlow</surname>
<given-names>Anthony</given-names>
</name>
<xref rid="aff92" ref-type="aff">92</xref>
<xref rid="aff116" ref-type="aff">116</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Borresen-Dale</surname>
<given-names>Anne-Lise</given-names>
</name>
<xref rid="aff4" ref-type="aff">4</xref>
<xref rid="aff117" ref-type="aff">117</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kristensen</surname>
<given-names>Vessela</given-names>
</name>
<xref rid="aff4" ref-type="aff">4</xref>
<xref rid="aff117" ref-type="aff">117</xref>
<xref rid="aff118" ref-type="aff">118</xref>
</contrib>
<contrib contrib-type="author"><name><surname>French</surname>
<given-names>Juliet D.</given-names>
</name>
<xref rid="aff2" ref-type="aff">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Edwards</surname>
<given-names>Stacey L.</given-names>
</name>
<xref rid="aff2" ref-type="aff">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dunning</surname>
<given-names>Alison M.</given-names>
</name>
<xref rid="aff6" ref-type="aff">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Easton</surname>
<given-names>Douglas F.</given-names>
</name>
<xref rid="aff3" ref-type="aff">3</xref>
<xref rid="aff6" ref-type="aff">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hall</surname>
<given-names>Per</given-names>
</name>
<xref rid="aff1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chenevix-Trench</surname>
<given-names>Georgia</given-names>
</name>
<email>georgia.trench@qimr.edu.au</email>
<xref rid="aff2" ref-type="aff">2</xref>
<xref rid="cor1" ref-type="corresp">∗</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</aff>
<aff id="aff2"><label>2</label>
Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia</aff>
<aff id="aff3"><label>3</label>
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</aff>
<aff id="aff4"><label>4</label>
Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, 0310 Oslo, Norway</aff>
<aff id="aff5"><label>5</label>
K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Kirkeveien 166, 0450 Oslo, Norway</aff>
<aff id="aff6"><label>6</label>
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</aff>
<aff id="aff7"><label>7</label>
Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</aff>
<aff id="aff8"><label>8</label>
Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</aff>
<aff id="aff9"><label>9</label>
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3010, Australia</aff>
<aff id="aff10"><label>10</label>
Department of Pathology, The University of Melbourne, Melbourne, VIC 3010, Australia</aff>
<aff id="aff11"><label>11</label>
Centre for Genetic Origins of Health and Disease, University of Western Australia, Crawley, WA 6009, Australia</aff>
<aff id="aff12"><label>12</label>
Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Newcastle, NSW 2308, Australia</aff>
<aff id="aff13"><label>13</label>
Division of Molecular Medicine, Pathology North, John Hunter Hospital and The Hunter Medical Research Institute, Newcastle, NSW 2305, Australia</aff>
<aff id="aff14"><label>14</label>
Division of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK</aff>
<aff id="aff15"><label>15</label>
Institute of Population Health, University of Manchester, Manchester M13 9PL, UK</aff>
<aff id="aff16"><label>16</label>
University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany</aff>
<aff id="aff17"><label>17</label>
Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany</aff>
<aff id="aff18"><label>18</label>
Department of Medicine Division of Hematology and Oncology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA</aff>
<aff id="aff19"><label>19</label>
Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK</aff>
<aff id="aff20"><label>20</label>
Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford OX3 7BN, UK</aff>
<aff id="aff21"><label>21</label>
Research Oncology, Division of Cancer Studies, King’s College London, Guy’s Hospital, London SE1 9RT, UK</aff>
<aff id="aff22"><label>22</label>
National Center for Tumor Diseases, University of Heidelberg, 69120 Heidelberg, Germany</aff>
<aff id="aff23"><label>23</label>
Division of Molecular Genetic Epidemiology, German Cancer Research Centre (DZFK), 69047 Heidelberg, Germany</aff>
<aff id="aff24"><label>24</label>
Department of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany</aff>
<aff id="aff25"><label>25</label>
University Paris-Sud, UMRS 1018, 94807 Villejuif, France</aff>
<aff id="aff26"><label>26</label>
INSERM (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 94807 Villejuif, France</aff>
<aff id="aff27"><label>27</label>
Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</aff>
<aff id="aff28"><label>28</label>
Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</aff>
<aff id="aff29"><label>29</label>
Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark</aff>
<aff id="aff30"><label>30</label>
Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</aff>
<aff id="aff31"><label>31</label>
Human Genotyping (CEGEN) Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain</aff>
<aff id="aff32"><label>32</label>
Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid 28029, Spain</aff>
<aff id="aff33"><label>33</label>
Biomedical Network on Rare Diseases (CIBERER), Madrid 28029, Spain</aff>
<aff id="aff34"><label>34</label>
Department of Epidemiology, University of California Irvine, Irvine, CA 92697, USA</aff>
<aff id="aff35"><label>35</label>
Beckman Research Institute of City of Hope, Duarte, CA 91010, USA</aff>
<aff id="aff36"><label>36</label>
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</aff>
<aff id="aff37"><label>37</label>
Division of Preventive Oncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</aff>
<aff id="aff38"><label>38</label>
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</aff>
<aff id="aff39"><label>39</label>
Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04107 Leipzig, Germany</aff>
<aff id="aff40"><label>40</label>
Division of Gynaecology and Obstetrics, Technische Universität München, 81675 Munich, Germany</aff>
<aff id="aff41"><label>41</label>
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne 50932, Germany</aff>
<aff id="aff42"><label>42</label>
Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, Cologne 50937, Germany</aff>
<aff id="aff43"><label>43</label>
Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne 50937, Germany</aff>
<aff id="aff44"><label>44</label>
Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, 24105 Kiel, Germany</aff>
<aff id="aff45"><label>45</label>
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany</aff>
<aff id="aff46"><label>46</label>
University of Tübingen, 72074 Tübingen, Germany</aff>
<aff id="aff47"><label>47</label>
Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</aff>
<aff id="aff48"><label>48</label>
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</aff>
<aff id="aff49"><label>49</label>
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, 00029 HUS, Finland</aff>
<aff id="aff50"><label>50</label>
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi 464-8681, Japan</aff>
<aff id="aff51"><label>51</label>
Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka 812-8582, Japan</aff>
<aff id="aff52"><label>52</label>
Department of Radiation Oncology, Hannover Medical School, 30625 Hannover, Germany</aff>
<aff id="aff53"><label>53</label>
Gynaecology Research Unit, Hannover Medical School, 30625 Hannover, Germany</aff>
<aff id="aff54"><label>54</label>
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 17177, Sweden</aff>
<aff id="aff55"><label>55</label>
Department of Oncology - Pathology, Karolinska Institutet, Stockholm 17177, Sweden</aff>
<aff id="aff56"><label>56</label>
School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio 70211, Finland</aff>
<aff id="aff57"><label>57</label>
Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio 70211, Finland</aff>
<aff id="aff58"><label>58</label>
Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio 70211, Finland</aff>
<aff id="aff59"><label>59</label>
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA</aff>
<aff id="aff60"><label>60</label>
University Hospital Gashuisberg, 3000 Leuven, Belgium</aff>
<aff id="aff61"><label>61</label>
Vesalius Research Center (VRC), VIB, Leuven 3000, Belgium</aff>
<aff id="aff62"><label>62</label>
Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven 3000, Belgium</aff>
<aff id="aff63"><label>63</label>
IFOM, the FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, 20139 Milan, Italy</aff>
<aff id="aff64"><label>64</label>
Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), 20133 Milan, Italy</aff>
<aff id="aff65"><label>65</label>
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA</aff>
<aff id="aff66"><label>66</label>
Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3053, Australia</aff>
<aff id="aff67"><label>67</label>
Anatomical Pathology, The Alfred Hospital, Melbourne, VIC 3004, Australia</aff>
<aff id="aff68"><label>68</label>
Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA</aff>
<aff id="aff69"><label>69</label>
Departments of Obstetrics & Gynaecology and Pediatrics, Dalhousie University, Halifax, NS B3H 4R2, Canada</aff>
<aff id="aff70"><label>70</label>
Department of Medicine, McGill University, Montreal, QC H3A 1W7, Canada</aff>
<aff id="aff71"><label>71</label>
Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, Montreal, QC H3H 2R9, Canada</aff>
<aff id="aff72"><label>72</label>
Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City, QC G1V 4G2, Canada</aff>
<aff id="aff73"><label>73</label>
Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre (UMMC), 50603 Kuala Lumpur, Malaysia</aff>
<aff id="aff74"><label>74</label>
Cancer Research Initiatives Foundation, Sime Darby Medical Centre, 47500 Subang Jaya, Malaysia</aff>
<aff id="aff75"><label>75</label>
Department of Oncology, Oslo University Hospital, Radiumhospitalet, 0310 Oslo, Norway</aff>
<aff id="aff76"><label>76</label>
Department of Genetics, Oslo University Hospital, Radiumhospitalet, 0310 Oslo, Norway</aff>
<aff id="aff77"><label>77</label>
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</aff>
<aff id="aff78"><label>78</label>
Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA</aff>
<aff id="aff79"><label>79</label>
Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</aff>
<aff id="aff80"><label>80</label>
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</aff>
<aff id="aff81"><label>81</label>
Department of Oncology, Oulu University Hospital and University of Oulu, 90014 Oulu, Finland</aff>
<aff id="aff82"><label>82</label>
Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, 90014 Oulu, Finland</aff>
<aff id="aff83"><label>83</label>
Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, 90220 Oulu, Finland</aff>
<aff id="aff84"><label>84</label>
Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada</aff>
<aff id="aff85"><label>85</label>
Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 3G3, Canada</aff>
<aff id="aff86"><label>86</label>
Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada</aff>
<aff id="aff87"><label>87</label>
Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5S 3G3, Canada</aff>
<aff id="aff88"><label>88</label>
Department of Human Genetics, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands</aff>
<aff id="aff89"><label>89</label>
Department of Pathology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands</aff>
<aff id="aff90"><label>90</label>
Department of Surgical Oncology, Leiden University Medical Center, 2333 ZC Leiden, the Netherlands</aff>
<aff id="aff91"><label>91</label>
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20850, USA</aff>
<aff id="aff92"><label>92</label>
Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton SM2 5NG, UK</aff>
<aff id="aff93"><label>93</label>
Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, London SW3 6JB, UK</aff>
<aff id="aff94"><label>94</label>
Department of Medical Oncology, Erasmus MC Cancer Institute, 3008 AE Rotterdam, the Netherlands</aff>
<aff id="aff95"><label>95</label>
Department of Surgical Oncology, Erasmus University Medical Center, 3075 EA Rotterdam, the Netherlands</aff>
<aff id="aff96"><label>96</label>
Human Genetics Division, Genome Institute of Singapore, Singapore 138672, Singapore</aff>
<aff id="aff97"><label>97</label>
Department of Epidemiology, Shanghai Cancer Institute, Xuhui, Shanghai 200031, China</aff>
<aff id="aff98"><label>98</label>
Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield S10 2RX, UK</aff>
<aff id="aff99"><label>99</label>
Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK</aff>
<aff id="aff100"><label>100</label>
Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</aff>
<aff id="aff101"><label>101</label>
Department of Public Health and Primary Care, University of Cambridge, Cambridge CB2 1TN, UK</aff>
<aff id="aff102"><label>102</label>
Department of Biomedical Science, Seoul National University College of Medicine, Seoul 110-799, Korea</aff>
<aff id="aff103"><label>103</label>
Department of Surgery, Seoul National University College of Medicine, Seoul 110-799, Korea</aff>
<aff id="aff104"><label>104</label>
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea</aff>
<aff id="aff105"><label>105</label>
Saw Swee Hock School of Public Health, National University of Singapore and Department of Surgery, National University Health System, Singapore 117597, Singapore</aff>
<aff id="aff106"><label>106</label>
Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore 119228, Singapore</aff>
<aff id="aff107"><label>107</label>
Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota 12362, Columbia</aff>
<aff id="aff108"><label>108</label>
Department of Genetics and Pathology, Pomeranian Medical University, 70-115 Szczecin, Poland</aff>
<aff id="aff109"><label>109</label>
International Agency for Research on Cancer, 69372 Lyon, CEDEX 08, France</aff>
<aff id="aff110"><label>110</label>
National Cancer Institute, Bangkok 10400, Thailand</aff>
<aff id="aff111"><label>111</label>
Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA</aff>
<aff id="aff112"><label>112</label>
Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research “Demokritos,” Aghia Paraskevi Attikis, 153 10 Athens, Greece</aff>
<aff id="aff113"><label>113</label>
Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan</aff>
<aff id="aff114"><label>114</label>
School of Public Health, China Medical University, Taichung 40402, Taiwan</aff>
<aff id="aff115"><label>115</label>
Department of Surgery, Tri-Service General Hospital, Taipei 114, Taiwan</aff>
<aff id="aff116"><label>116</label>
Division of Breast Cancer Research, Institute of Cancer Research, Sutton SM2 5NG, UK</aff>
<aff id="aff117"><label>117</label>
Institute of Clinical Medicine, University of Oslo (UiO), Oslo 0316, Norway</aff>
<aff id="aff118"><label>118</label>
Department of Clinical Molecular Biology (EpiGen), University of Oslo (UiO), Oslo 0316, Norway</aff>
<author-notes><corresp id="cor1"><label>∗</label>
Corresponding author <email>georgia.trench@qimr.edu.au</email>
</corresp>
<fn id="fn1"><label>119</label>
<p>These authors contributed equally to this work</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><day>02</day>
<month>7</month>
<year>2015</year>
</pub-date>
<volume>97</volume>
<issue>1</issue>
<fpage>22</fpage>
<lpage>34</lpage>
<history><date date-type="received"><day>8</day>
<month>2</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>1</day>
<month>5</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>© 2015 The American Society of Human Genetics. Published by Elsevier Ltd. All right reserved.</copyright-statement>
<copyright-year>2015</copyright-year>
<copyright-holder>The American Society of Human Genetics</copyright-holder>
</permissions>
<abstract><p>Genome-wide association studies have identified SNPs near <italic>ZNF365</italic>
at 10q21.2 that are associated with both breast cancer risk and mammographic density. To identify the most likely causal SNPs, we fine mapped the association signal by genotyping 428 SNPs across the region in 89,050 European and 12,893 Asian case and control subjects from the Breast Cancer Association Consortium. We identified four independent sets of correlated, highly trait-associated variants (iCHAVs), three of which were located within <italic>ZNF365</italic>
. The most strongly risk-associated SNP, rs10995201 in iCHAV1, showed clear evidence of association with both estrogen receptor (ER)-positive (OR = 0.85 [0.82–0.88]) and ER-negative (OR = 0.87 [0.82–0.91]) disease, and was also the SNP most strongly associated with percent mammographic density. iCHAV2 (lead SNP, chr10: 64,258,684:D) and iCHAV3 (lead SNP, rs7922449) were also associated with ER-positive (OR = 0.93 [0.91–0.95] and OR = 1.06 [1.03–1.09]) and ER-negative (OR = 0.95 [0.91–0.98] and OR = 1.08 [1.04–1.13]) disease. There was weaker evidence for iCHAV4, located 5′ of <italic>ADO</italic>
, associated only with ER-positive breast cancer (OR = 0.93 [0.90–0.96]). We found 12, 17, 18, and 2 candidate causal SNPs for breast cancer in iCHAVs 1–4, respectively. Chromosome conformation capture analysis showed that iCHAV2 interacts with the <italic>ZNF365</italic>
and <italic>NRBF2</italic>
(more than 600 kb away) promoters in normal and cancerous breast epithelial cells. Luciferase assays did not identify SNPs that affect transactivation of <italic>ZNF365,</italic>
but identified a protective haplotype in iCHAV2, associated with silencing of the <italic>NRBF2</italic>
promoter, implicating this gene in the etiology of breast cancer.</p>
</abstract>
</article-meta>
<notes><p id="misc0010">Published: June 11, 2015</p>
</notes>
</front>
</pmc>
</record>
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