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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A locus on 19p13 modifies risk of breast cancer in <italic>BRCA1</italic> mutation carriers and is associated with hormone receptor–negative breast cancer in the general population</title><author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C" last="Antoniou">Antonis C. Antoniou</name><affiliation><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><nlm:aff id="A2"> Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Fredericksen, Zachary S" sort="Fredericksen, Zachary S" uniqKey="Fredericksen Z" first="Zachary S" last="Fredericksen">Zachary S. Fredericksen</name><affiliation><nlm:aff id="A3"> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name><affiliation><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Tarrell, Robert" sort="Tarrell, Robert" uniqKey="Tarrell R" first="Robert" last="Tarrell">Robert Tarrell</name><affiliation><nlm:aff id="A3"> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M" last="Sinilnikova">Olga M. Sinilnikova</name><affiliation><nlm:aff id="A4"> Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="A5"> Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name><affiliation><nlm:aff id="A6"> Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Morrison, Jonathan" sort="Morrison, Jonathan" uniqKey="Morrison J" first="Jonathan" last="Morrison">Jonathan Morrison</name><affiliation><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Kartsonaki, Christiana" sort="Kartsonaki, Christiana" uniqKey="Kartsonaki C" first="Christiana" last="Kartsonaki">Christiana Kartsonaki</name><affiliation><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Lesnick, Timothy" sort="Lesnick, Timothy" uniqKey="Lesnick T" first="Timothy" last="Lesnick">Timothy Lesnick</name><affiliation><nlm:aff id="A3"> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Ghoussaini, Maya" sort="Ghoussaini, Maya" uniqKey="Ghoussaini M" first="Maya" last="Ghoussaini">Maya Ghoussaini</name><affiliation><nlm:aff id="A6"> Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Barrowdale, Daniel" sort="Barrowdale, Daniel" uniqKey="Barrowdale D" first="Daniel" last="Barrowdale">Daniel Barrowdale</name><affiliation><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Peock, Susan" sort="Peock, Susan" uniqKey="Peock S" first="Susan" last="Peock">Susan Peock</name><affiliation><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Cook, Margaret" sort="Cook, Margaret" uniqKey="Cook M" first="Margaret" last="Cook">Margaret Cook</name><affiliation><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Oliver, Clare" sort="Oliver, Clare" uniqKey="Oliver C" first="Clare" last="Oliver">Clare Oliver</name><affiliation><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Frost, Debra" sort="Frost, Debra" uniqKey="Frost D" first="Debra" last="Frost">Debra Frost</name><affiliation><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Eccles, Diana" sort="Eccles, Diana" uniqKey="Eccles D" first="Diana" last="Eccles">Diana Eccles</name><affiliation><nlm:aff id="A7"> Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK</nlm:aff></affiliation></author><author><name sortKey="Evans, D Gareth" sort="Evans, D Gareth" uniqKey="Evans D" first="D Gareth" last="Evans">D Gareth Evans</name><affiliation><nlm:aff id="A8"> Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals National Health Service (NHSFT) Foundation Trust, Manchester, UK</nlm:aff></affiliation></author><author><name sortKey="Eeles, Ros" sort="Eeles, Ros" uniqKey="Eeles R" first="Ros" last="Eeles">Ros Eeles</name><affiliation><nlm:aff id="A9"> Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK</nlm:aff></affiliation></author><author><name sortKey="Izatt, Louise" sort="Izatt, Louise" uniqKey="Izatt L" first="Louise" last="Izatt">Louise Izatt</name><affiliation><nlm:aff id="A10"> Clinical Genetics, Guy’s and St. Thomas’ NHS Foundation Trust, London, UK</nlm:aff></affiliation></author><author><name sortKey="Chu, Carol" sort="Chu, Carol" uniqKey="Chu C" first="Carol" last="Chu">Carol Chu</name><affiliation><nlm:aff id="A11"> Yorkshire Regional Genetics Service, Leeds, UK</nlm:aff></affiliation></author><author><name sortKey="Douglas, Fiona" sort="Douglas, Fiona" uniqKey="Douglas F" first="Fiona" last="Douglas">Fiona Douglas</name><affiliation><nlm:aff id="A12"> Institute of Human Genetics, Centre for Life, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK</nlm:aff></affiliation></author><author><name sortKey="Paterson, Joan" sort="Paterson, Joan" uniqKey="Paterson J" first="Joan" last="Paterson">Joan Paterson</name><affiliation><nlm:aff id="A13"> Department of Clinical Genetics, East Anglian Regional Genetics Service, Addenbrookes Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><affiliation><nlm:aff id="A14"> INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Houdayer, Claude" sort="Houdayer, Claude" uniqKey="Houdayer C" first="Claude" last="Houdayer">Claude Houdayer</name><affiliation><nlm:aff id="A14"> INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name><affiliation><nlm:aff id="A5"> Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Giraud, Sophie" sort="Giraud, Sophie" uniqKey="Giraud S" first="Sophie" last="Giraud">Sophie Giraud</name><affiliation><nlm:aff id="A4"> Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Lasset, Christine" sort="Lasset, Christine" uniqKey="Lasset C" first="Christine" last="Lasset">Christine Lasset</name><affiliation><nlm:aff id="A15"> CNRS UMR5558, Université Lyon 1, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="A16"> Unité de Prévention et d’Epidémiologie Génétique, Centre Léon Bérard, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Remenieras, Audrey" sort="Remenieras, Audrey" uniqKey="Remenieras A" first="Audrey" last="Remenieras">Audrey Remenieras</name><affiliation><nlm:aff id="A17"> Genetics Department, Institut de Cancérologie Gustave Roussy, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Caron, Olivier" sort="Caron, Olivier" uniqKey="Caron O" first="Olivier" last="Caron">Olivier Caron</name><affiliation><nlm:aff id="A18"> Consultation de Génétique, Département de Médecine, Institut de Cancérologie Gustave Roussy, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Hardouin, Agnes" sort="Hardouin, Agnes" uniqKey="Hardouin A" first="Agnès" last="Hardouin">Agnès Hardouin</name><affiliation><nlm:aff id="A19"> Centre François Baclesse, Caen, France</nlm:aff></affiliation></author><author><name sortKey="Berthet, Pascaline" sort="Berthet, Pascaline" uniqKey="Berthet P" first="Pascaline" last="Berthet">Pascaline Berthet</name><affiliation><nlm:aff id="A19"> Centre François Baclesse, Caen, France</nlm:aff></affiliation></author><author><name sortKey="Hogervorst, Frans B L" sort="Hogervorst, Frans B L" uniqKey="Hogervorst F" first="Frans B L" last="Hogervorst">Frans B L. Hogervorst</name><affiliation><nlm:aff id="A21"> Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Rookus, Matti A" sort="Rookus, Matti A" uniqKey="Rookus M" first="Matti A" last="Rookus">Matti A. Rookus</name><affiliation><nlm:aff id="A22"> Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Jager, Agnes" sort="Jager, Agnes" uniqKey="Jager A" first="Agnes" last="Jager">Agnes Jager</name><affiliation><nlm:aff id="A23"> Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Den Ouweland, Ans" sort="Van Den Ouweland, Ans" uniqKey="Van Den Ouweland A" first="Ans" last="Van Den Ouweland">Ans Van Den Ouweland</name><affiliation><nlm:aff id="A24"> Department of Clinical Genetics, Rotterdam Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hoogerbrugge, Nicoline" sort="Hoogerbrugge, Nicoline" uniqKey="Hoogerbrugge N" first="Nicoline" last="Hoogerbrugge">Nicoline Hoogerbrugge</name><affiliation><nlm:aff id="A25"> Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Der Luijt, Rob B" sort="Van Der Luijt, Rob B" uniqKey="Van Der Luijt R" first="Rob B" last="Van Der Luijt">Rob B. Van Der Luijt</name><affiliation><nlm:aff id="A26"> Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Meijers Heijboer, Hanne" sort="Meijers Heijboer, Hanne" uniqKey="Meijers Heijboer H" first="Hanne" last="Meijers-Heijboer">Hanne Meijers-Heijboer</name><affiliation><nlm:aff id="A27"> Department of Clinical Genetics, Vrije Universiteit (VU) Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Garcia, Encarna B G Mez" sort="Garcia, Encarna B G Mez" uniqKey="Garcia E" first="Encarna B G Mez" last="García">Encarna B G Mez García</name><affiliation><nlm:aff id="A28"> Department of Clinical Genetics, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:aff id="A30"> Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A31"> Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Vreeswijk, Maaike P G" sort="Vreeswijk, Maaike P G" uniqKey="Vreeswijk M" first="Maaike P G" last="Vreeswijk">Maaike P G. Vreeswijk</name><affiliation><nlm:aff id="A32"> Department of Toxicogenetics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="A33"> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="A33"> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Gronwald, Jacek" sort="Gronwald, Jacek" uniqKey="Gronwald J" first="Jacek" last="Gronwald">Jacek Gronwald</name><affiliation><nlm:aff id="A33"> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Huzarski, Tomasz" sort="Huzarski, Tomasz" uniqKey="Huzarski T" first="Tomasz" last="Huzarski">Tomasz Huzarski</name><affiliation><nlm:aff id="A33"> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Byrski, Tomasz" sort="Byrski, Tomasz" uniqKey="Byrski T" first="Tomasz" last="Byrski">Tomasz Byrski</name><affiliation><nlm:aff id="A33"> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="G Rski, Bohdan" sort="G Rski, Bohdan" uniqKey="G Rski B" first="Bohdan" last="G Rski">Bohdan G Rski</name><affiliation><nlm:aff id="A33"> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Cybulski, Cezary" sort="Cybulski, Cezary" uniqKey="Cybulski C" first="Cezary" last="Cybulski">Cezary Cybulski</name><affiliation><nlm:aff id="A33"> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B" last="Spurdle">Amanda B. Spurdle</name><affiliation><nlm:aff id="A6"> Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Holland, Helene" sort="Holland, Helene" uniqKey="Holland H" first="Helene" last="Holland">Helene Holland</name><affiliation><nlm:aff id="A6"> Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E" last="Goldgar">David E. Goldgar</name><affiliation><nlm:aff id="A35"> Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, USA</nlm:aff></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M" last="John">Esther M. John</name><affiliation><nlm:aff id="A36"> Cancer Prevention Institute of California, Stanford University School of Medicine, Stanford, California, USA</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="A37"> The University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa" sort="Southey, Melissa" uniqKey="Southey M" first="Melissa" last="Southey">Melissa Southey</name><affiliation><nlm:aff id="A37"> The University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Buys, Saundra S" sort="Buys, Saundra S" uniqKey="Buys S" first="Saundra S" last="Buys">Saundra S. Buys</name><affiliation><nlm:aff id="A38"> Huntsman Cancer Institute, University of Utah Health Sciences Centre, Salt Lake City, Utah, USA</nlm:aff></affiliation></author><author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B" last="Daly">Mary B. Daly</name><affiliation><nlm:aff id="A39"> Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Terry, Mary Beth" sort="Terry, Mary Beth" uniqKey="Terry M" first="Mary-Beth" last="Terry">Mary-Beth Terry</name><affiliation><nlm:aff id="A40"> Columbia University, New York, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K" last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="A41"> Centre of Familial Breast and Ovarian Cancer, Department of Obstetrics and Gynaecology, University of Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A42"> Centre for Integrated Oncology (CIO), University of Cologne, Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Wappenschmidt, Barbara" sort="Wappenschmidt, Barbara" uniqKey="Wappenschmidt B" first="Barbara" last="Wappenschmidt">Barbara Wappenschmidt</name><affiliation><nlm:aff id="A41"> Centre of Familial Breast and Ovarian Cancer, Department of Obstetrics and Gynaecology, University of Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A42"> Centre for Integrated Oncology (CIO), University of Cologne, Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Engel, Christoph" sort="Engel, Christoph" uniqKey="Engel C" first="Christoph" last="Engel">Christoph Engel</name><affiliation><nlm:aff id="A43"> Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="A44"> Department of Obstetrics and Gynaecology, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Preisler Adams, Sabine" sort="Preisler Adams, Sabine" uniqKey="Preisler Adams S" first="Sabine" last="Preisler-Adams">Sabine Preisler-Adams</name><affiliation><nlm:aff id="A45"> Institute of Human Genetics, University of Muenster, Muenster, Germany</nlm:aff></affiliation></author><author><name sortKey="Arnold, Norbert" sort="Arnold, Norbert" uniqKey="Arnold N" first="Norbert" last="Arnold">Norbert Arnold</name><affiliation><nlm:aff id="A46"> Department of Obstetrics and Gynaecology, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University, Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Niederacher, Dieter" sort="Niederacher, Dieter" uniqKey="Niederacher D" first="Dieter" last="Niederacher">Dieter Niederacher</name><affiliation><nlm:aff id="A47"> Department of Obstetrics and Gynaecology, Division of Molecular Genetics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Dusseldorf, Germany</nlm:aff></affiliation></author><author><name sortKey="Sutter, Christian" sort="Sutter, Christian" uniqKey="Sutter C" first="Christian" last="Sutter">Christian Sutter</name><affiliation><nlm:aff id="A48"> Institute of Human Genetics, Division of Molecular Diagnostics, University Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M" last="Domchek">Susan M. Domchek</name><affiliation><nlm:aff id="A49"> University of Pennsylvania, Philadelphia, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L" last="Nathanson">Katherine L. Nathanson</name><affiliation><nlm:aff id="A49"> University of Pennsylvania, Philadelphia, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Rebbeck, Timothy" sort="Rebbeck, Timothy" uniqKey="Rebbeck T" first="Timothy" last="Rebbeck">Timothy Rebbeck</name><affiliation><nlm:aff id="A49"> University of Pennsylvania, Philadelphia, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Blum, Joanne L" sort="Blum, Joanne L" uniqKey="Blum J" first="Joanne L" last="Blum">Joanne L. Blum</name><affiliation><nlm:aff id="A50"> Baylor-Charles A. Sammons Cancer Center, Dallas, Texas, USA</nlm:aff></affiliation></author><author><name sortKey="Piedmonte, Marion" sort="Piedmonte, Marion" uniqKey="Piedmonte M" first="Marion" last="Piedmonte">Marion Piedmonte</name><affiliation><nlm:aff id="A51"> Gynecology Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Rodriguez, Gustavo C" sort="Rodriguez, Gustavo C" uniqKey="Rodriguez G" first="Gustavo C" last="Rodriguez">Gustavo C. Rodriguez</name><affiliation><nlm:aff id="A52"> Northshore University Health System, Evanston Northwestern Healthcare, Evanston, Illinois, USA</nlm:aff></affiliation></author><author><name sortKey="Wakeley, Katie" sort="Wakeley, Katie" uniqKey="Wakeley K" first="Katie" last="Wakeley">Katie Wakeley</name><affiliation><nlm:aff id="A53"> Tufts University, New England Medical Center, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Boggess, John F" sort="Boggess, John F" uniqKey="Boggess J" first="John F" last="Boggess">John F. Boggess</name><affiliation><nlm:aff id="A54"> University of North Carolina, Chapel Hill, North Carolina, USA</nlm:aff></affiliation></author><author><name sortKey="Basil, Jack" sort="Basil, Jack" uniqKey="Basil J" first="Jack" last="Basil">Jack Basil</name><affiliation><nlm:aff id="A55"> St. Elizabeth Medical Center, Edgewood, Kentucky, USA</nlm:aff></affiliation></author><author><name sortKey="Blank, Stephanie V" sort="Blank, Stephanie V" uniqKey="Blank S" first="Stephanie V" last="Blank">Stephanie V. Blank</name><affiliation><nlm:aff id="A56"> New York University School of Medicine, New York, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name><affiliation><nlm:aff id="A57"> The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel</nlm:aff></affiliation></author><author><name sortKey="Kaufman, Bella" sort="Kaufman, Bella" uniqKey="Kaufman B" first="Bella" last="Kaufman">Bella Kaufman</name><affiliation><nlm:aff id="A58"> Oncology Institute, Sheba Medical Center, Tel-Hashomer, Israel</nlm:aff></affiliation></author><author><name sortKey="Laitman, Yael" sort="Laitman, Yael" uniqKey="Laitman Y" first="Yael" last="Laitman">Yael Laitman</name><affiliation><nlm:aff id="A57"> The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel</nlm:aff></affiliation></author><author><name sortKey="Milgrom, Roni" sort="Milgrom, Roni" uniqKey="Milgrom R" first="Roni" last="Milgrom">Roni Milgrom</name><affiliation><nlm:aff id="A57"> The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L" last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="A59"> Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A60"> Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A61"> Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="A59"> Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Ozcelik, Hilmi" sort="Ozcelik, Hilmi" uniqKey="Ozcelik H" first="Hilmi" last="Ozcelik">Hilmi Ozcelik</name><affiliation><nlm:aff id="A60"> Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Kirchhoff, Tomas" sort="Kirchhoff, Tomas" uniqKey="Kirchhoff T" first="Tomas" last="Kirchhoff">Tomas Kirchhoff</name><affiliation><nlm:aff id="A62"> Clinical Genetics Service, Memorial Hospital, New York, New York, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A63"> Cancer Biology and Genetics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Vijai, Joseph" sort="Vijai, Joseph" uniqKey="Vijai J" first="Joseph" last="Vijai">Joseph Vijai</name><affiliation><nlm:aff id="A62"> Clinical Genetics Service, Memorial Hospital, New York, New York, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A63"> Cancer Biology and Genetics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M" last="Gaudet">Mia M. Gaudet</name><affiliation><nlm:aff id="A64"> Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, New York, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A65"> Department of Obstetrics and Gynecology and Women’s Health, Albert Einstein College of Medicine, New York, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Altshuler, David" sort="Altshuler, David" uniqKey="Altshuler D" first="David" last="Altshuler">David Altshuler</name><affiliation><nlm:aff id="A66"> Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Guiducci, Candace" sort="Guiducci, Candace" uniqKey="Guiducci C" first="Candace" last="Guiducci">Candace Guiducci</name><affiliation><nlm:aff id="A66"> Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Loman, Niklas" sort="Loman, Niklas" uniqKey="Loman N" first="Niklas" last="Loman">Niklas Loman</name><affiliation><nlm:aff id="A68"> Department of Oncology, Lund University, Lund, Sweden</nlm:aff></affiliation></author><author><name sortKey="Harbst, Katja" sort="Harbst, Katja" uniqKey="Harbst K" first="Katja" last="Harbst">Katja Harbst</name><affiliation><nlm:aff id="A68"> Department of Oncology, Lund University, Lund, Sweden</nlm:aff></affiliation></author><author><name sortKey="Rantala, Johanna" sort="Rantala, Johanna" uniqKey="Rantala J" first="Johanna" last="Rantala">Johanna Rantala</name><affiliation><nlm:aff id="A69"> Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Ehrencrona, Hans" sort="Ehrencrona, Hans" uniqKey="Ehrencrona H" first="Hans" last="Ehrencrona">Hans Ehrencrona</name><affiliation><nlm:aff id="A70"> Department of Genetics and Pathology Rudbeck Laboratory, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Gerdes, Anne Marie" sort="Gerdes, Anne Marie" uniqKey="Gerdes A" first="Anne-Marie" last="Gerdes">Anne-Marie Gerdes</name><affiliation><nlm:aff id="A71"> Department of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name><affiliation><nlm:aff id="A72"> Department of Clinical Genetics, Odense University Hospital, Odense, Denmark</nlm:aff></affiliation></author><author><name sortKey="Sunde, Lone" sort="Sunde, Lone" uniqKey="Sunde L" first="Lone" last="Sunde">Lone Sunde</name><affiliation><nlm:aff id="A73"> Department of Clinical Genetics, Aalborg and Aarhus University Hospital, Aaarhus, Denmark</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="A74"> Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A75"> IFOM, Fondazione Istituto Fondazione Italiana per la Ricera sul Cancro (FIRC) di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="A76"> Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name><affiliation><nlm:aff id="A77"> Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Viel, Alessandra" sort="Viel, Alessandra" uniqKey="Viel A" first="Alessandra" last="Viel">Alessandra Viel</name><affiliation><nlm:aff id="A78"> Division of Experimental Oncology, Centro di Riferimento Oncologico (CRO), IRCCS, Aviano (PN), Italy</nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="A74"> Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A75"> IFOM, Fondazione Istituto Fondazione Italiana per la Ricera sul Cancro (FIRC) di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Caldes, Trinidad" sort="Caldes, Trinidad" uniqKey="Caldes T" first="Trinidad" last="Caldes">Trinidad Caldes</name><affiliation><nlm:aff id="A79"> Hospital Clinico San Carlos, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="De La Hoya, Miguel" sort="De La Hoya, Miguel" uniqKey="De La Hoya M" first="Miguel" last="De La Hoya">Miguel De La Hoya</name><affiliation><nlm:aff id="A77"> Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Singer, Christian F" sort="Singer, Christian F" uniqKey="Singer C" first="Christian F" last="Singer">Christian F. Singer</name><affiliation><nlm:aff id="A80"> Department of Obstetrics/Gynocology, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Fink Retter, Anneliese" sort="Fink Retter, Anneliese" uniqKey="Fink Retter A" first="Anneliese" last="Fink-Retter">Anneliese Fink-Retter</name><affiliation><nlm:aff id="A80"> Department of Obstetrics/Gynocology, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H" last="Greene">Mark H. Greene</name><affiliation><nlm:aff id="A81"> Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L" last="Mai">Phuong L. Mai</name><affiliation><nlm:aff id="A81"> Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Loud, Jennifer T" sort="Loud, Jennifer T" uniqKey="Loud J" first="Jennifer T" last="Loud">Jennifer T. Loud</name><affiliation><nlm:aff id="A81"> Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Guidugli, Lucia" sort="Guidugli, Lucia" uniqKey="Guidugli L" first="Lucia" last="Guidugli">Lucia Guidugli</name><affiliation><nlm:aff id="A2"> Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Lindor, Noralane M" sort="Lindor, Noralane M" uniqKey="Lindor N" first="Noralane M" last="Lindor">Noralane M. Lindor</name><affiliation><nlm:aff id="A82"> Medical Genetics, Mayo Clinic Rochester, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Hansen, Thomas V O" sort="Hansen, Thomas V O" uniqKey="Hansen T" first="Thomas V O" last="Hansen">Thomas V O. Hansen</name><affiliation><nlm:aff id="A83"> Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nielsen, Finn C" sort="Nielsen, Finn C" uniqKey="Nielsen F" first="Finn C" last="Nielsen">Finn C. Nielsen</name><affiliation><nlm:aff id="A83"> Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Blanco, Ignacio" sort="Blanco, Ignacio" uniqKey="Blanco I" first="Ignacio" last="Blanco">Ignacio Blanco</name><affiliation><nlm:aff id="A84"> Hereditary Cancer Program, Catalan Institute of Oncology, Gran Via de l’Hospitalet, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Lazaro, Conxi" sort="Lazaro, Conxi" uniqKey="Lazaro C" first="Conxi" last="Lazaro">Conxi Lazaro</name><affiliation><nlm:aff id="A84"> Hereditary Cancer Program, Catalan Institute of Oncology, Gran Via de l’Hospitalet, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Garber, Judy" sort="Garber, Judy" uniqKey="Garber J" first="Judy" last="Garber">Judy Garber</name><affiliation><nlm:aff id="A85"> Dana-Farber Cancer Institute, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Ramus, Susan J" sort="Ramus, Susan J" uniqKey="Ramus S" first="Susan J" last="Ramus">Susan J. Ramus</name><affiliation><nlm:aff id="A86"> Department of Gynaecological Oncology, University College London, Elizabeth Garrett Anderson (EGA) Institute for Women’s Health, London, UK</nlm:aff></affiliation></author><author><name sortKey="Gayther, Simon A" sort="Gayther, Simon A" uniqKey="Gayther S" first="Simon A" last="Gayther">Simon A. Gayther</name><affiliation><nlm:aff id="A86"> Department of Gynaecological Oncology, University College London, Elizabeth Garrett Anderson (EGA) Institute for Women’s Health, London, UK</nlm:aff></affiliation></author><author><name sortKey="Phelan, Catherine" sort="Phelan, Catherine" uniqKey="Phelan C" first="Catherine" last="Phelan">Catherine Phelan</name><affiliation><nlm:aff id="A87"> Women’s College Research Institute, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Narod, Stephen" sort="Narod, Stephen" uniqKey="Narod S" first="Stephen" last="Narod">Stephen Narod</name><affiliation><nlm:aff id="A88"> Department of Epidemiology and Genetics, H. Lee Moffitt Cancer Center, Tampa, Florida, USA</nlm:aff></affiliation></author><author><name sortKey="Szabo, Csilla I" sort="Szabo, Csilla I" uniqKey="Szabo C" first="Csilla I" last="Szabo">Csilla I. Szabo</name><affiliation><nlm:aff id="A2"> Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="A90"> Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name><affiliation><nlm:aff id="A90"> Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="A91"> Helsinki University Central Hospital, Department of Obstetrics and Gynecology, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Heikkinen, Tuomas" sort="Heikkinen, Tuomas" uniqKey="Heikkinen T" first="Tuomas" last="Heikkinen">Tuomas Heikkinen</name><affiliation><nlm:aff id="A91"> Helsinki University Central Hospital, Department of Obstetrics and Gynecology, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Caligo, Maria A" sort="Caligo, Maria A" uniqKey="Caligo M" first="Maria A" last="Caligo">Maria A. Caligo</name><affiliation><nlm:aff id="A92"> Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, Pisa University Hospital, Pisa, Italy</nlm:aff></affiliation></author><author><name sortKey="Beattie, Mary S" sort="Beattie, Mary S" uniqKey="Beattie M" first="Mary S" last="Beattie">Mary S. Beattie</name><affiliation><nlm:aff id="A93"> Department of Medicine, University of California, San Francisco, San Francisco, California, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A94"> Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A95"> Cancer Risk Program, Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco, California, USA</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="A96"> German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K" last="Godwin">Andrew K. Godwin</name><affiliation><nlm:aff id="A39"> Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name><affiliation><nlm:aff id="A97"> Istituto Oncologico Veneto-IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy</nlm:aff></affiliation></author><author><name sortKey="Casella, Cinzia" sort="Casella, Cinzia" uniqKey="Casella C" first="Cinzia" last="Casella">Cinzia Casella</name><affiliation><nlm:aff id="A97"> Istituto Oncologico Veneto-IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy</nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L" last="Neuhausen">Susan L. Neuhausen</name><affiliation><nlm:aff id="A98"> Department of Population Sciences, The Beckman Research Institute of the City of Hope, Duarte, California, USA</nlm:aff></affiliation></author><author><name sortKey="Karlan, Beth Y" sort="Karlan, Beth Y" uniqKey="Karlan B" first="Beth Y" last="Karlan">Beth Y. Karlan</name><affiliation><nlm:aff id="A99"> Women’s Cancer Research Institute at the Samuel Oschin Cancer Institute, Division of Gynecologic Oncology, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A100"> Department of Obstetrics and Gynecology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Tung, Nadine" sort="Tung, Nadine" uniqKey="Tung N" first="Nadine" last="Tung">Nadine Tung</name><affiliation><nlm:aff id="A101"> Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E" last="Toland">Amanda E. Toland</name><affiliation><nlm:aff id="A102"> Comprehensive Cancer Center, Department of Molecular Virology, Immunology and Medical Genetics, Division of Human Genetics, Department of Internal Medicine, Ohio State University, Columbus, Ohio, USA</nlm:aff></affiliation></author><author><name sortKey="Weitzel, Jeffrey" sort="Weitzel, Jeffrey" uniqKey="Weitzel J" first="Jeffrey" last="Weitzel">Jeffrey Weitzel</name><affiliation><nlm:aff id="A103"> Division of Clinical Cancer Genetics, City of Hope Cancer Center, Duarte, California, USA</nlm:aff></affiliation></author><author><name sortKey="Olopade, Olofunmilayo" sort="Olopade, Olofunmilayo" uniqKey="Olopade O" first="Olofunmilayo" last="Olopade">Olofunmilayo Olopade</name><affiliation><nlm:aff id="A104"> University of Chicago Medical Center, Chicago, Illinois, USA</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="A105"> Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Quebec, Québec City, Quebec, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A106"> Université Laval, Centre de recherche du Centre Hospitalier Universitaire de Quebéc (CHUQ), Québec City, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name><affiliation><nlm:aff id="A105"> Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Quebec, Québec City, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Rubinstein, Wendy S" sort="Rubinstein, Wendy S" uniqKey="Rubinstein W" first="Wendy S" last="Rubinstein">Wendy S. Rubinstein</name><affiliation><nlm:aff id="A107"> Northshore University Health System, Evanston, Illinois, USA</nlm:aff></affiliation></author><author><name sortKey="Arason, Adalgeir" sort="Arason, Adalgeir" uniqKey="Arason A" first="Adalgeir" last="Arason">Adalgeir Arason</name><affiliation><nlm:aff id="A108"> Department of Pathology, Landspitali University Hospital, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name><affiliation><nlm:aff id="A109"> QIMR GWAS Collective, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name><affiliation><nlm:aff id="A110"> Clalit Health Services National Cancer Control Center, Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Technion, Haifa, Israel</nlm:aff></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W" last="Montgomery">Grant W. Montgomery</name><affiliation><nlm:aff id="A110"> Clalit Health Services National Cancer Control Center, Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Technion, Haifa, Israel</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="A111"> Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="A112"> Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="A113"> Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A114"> University Tübingen, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff id="A116"> Melbourne Collaborative Cohort Study (MCCS), Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation><nlm:aff id="A116"> Melbourne Collaborative Cohort Study (MCCS), Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="A117"> Institute for Cancer Studies, Department of Oncology, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S" last="Cross">Simon S. Cross</name><affiliation><nlm:aff id="A118"> Academic Unit of Pathology, Department of Neuroscience, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Miron, Penelope" sort="Miron, Penelope" uniqKey="Miron P" first="Penelope" last="Miron">Penelope Miron</name><affiliation><nlm:aff id="A119"> Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Gerty, Sue M" sort="Gerty, Sue M" uniqKey="Gerty S" first="Sue M" last="Gerty">Sue M. Gerty</name><affiliation><nlm:aff id="A7"> Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK</nlm:aff></affiliation></author><author><name sortKey="Tapper, William" sort="Tapper, William" uniqKey="Tapper W" first="William" last="Tapper">William Tapper</name><affiliation><nlm:aff id="A7"> Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK</nlm:aff></affiliation></author><author><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name><affiliation><nlm:aff id="A120"> Molecular Diagnostics Laboratory Institute of Radioisotopes and Radiodiagnostic Products, National Centre for Scientific Research ‘Demokritos’, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Fountzilas, George" sort="Fountzilas, George" uniqKey="Fountzilas G" first="George" last="Fountzilas">George Fountzilas</name><affiliation><nlm:aff id="A121"> Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A122"> Hellenic Cooperative Oncology Group, Greece</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A" last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="A123"> University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W" last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="A124"> University Hospital Erlangen, Department of Gynecology and Obstetrics, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Silva, Isabel Dos Santos" sort="Silva, Isabel Dos Santos" uniqKey="Silva I" first="Isabel Dos Santos" last="Silva">Isabel Dos Santos Silva</name><affiliation><nlm:aff id="A125"> Cancer Research UK Epidemiology and Genetics Group, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="A125"> Cancer Research UK Epidemiology and Genetics Group, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="A126"> Vesalius Research Center (VRC), VIB, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Paridaens, Robert" sort="Paridaens, Robert" uniqKey="Paridaens R" first="Robert" last="Paridaens">Robert Paridaens</name><affiliation><nlm:aff id="A127"> Multidisciplinary Breast Center, University Hospitals Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Rudiger, Thomas" sort="Rudiger, Thomas" uniqKey="Rudiger T" first="Thomas" last="Rüdiger">Thomas Rüdiger</name><affiliation><nlm:aff id="A128"> Institute of Pathology, Städtisches Klinikum Karlsruhe, Karlsruhe, Germany</nlm:aff></affiliation></author><author><name sortKey="Forsti, Asta" sort="Forsti, Asta" uniqKey="Forsti A" first="Asta" last="Försti">Asta Försti</name><affiliation><nlm:aff id="A96"> German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A129"> Center for Primary Health Care Research, University of Lund, Lund, Sweden</nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="A130"> Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation><nlm:aff id="A130"> Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Diasio, Robert B" sort="Diasio, Robert B" uniqKey="Diasio R" first="Robert B" last="Diasio">Robert B. Diasio</name><affiliation><nlm:aff id="A131"> Department of Pharmacology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Lee, Adam M" sort="Lee, Adam M" uniqKey="Lee A" first="Adam M" last="Lee">Adam M. Lee</name><affiliation><nlm:aff id="A131"> Department of Pharmacology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Eckel Passow, Jeanette" sort="Eckel Passow, Jeanette" uniqKey="Eckel Passow J" first="Jeanette" last="Eckel-Passow">Jeanette Eckel-Passow</name><affiliation><nlm:aff id="A3"> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name><affiliation><nlm:aff id="A3"> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Blows, Fiona" sort="Blows, Fiona" uniqKey="Blows F" first="Fiona" last="Blows">Fiona Blows</name><affiliation><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Driver, Kristy" sort="Driver, Kristy" uniqKey="Driver K" first="Kristy" last="Driver">Kristy Driver</name><affiliation><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison" sort="Dunning, Alison" uniqKey="Dunning A" first="Alison" last="Dunning">Alison Dunning</name><affiliation><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul P D" sort="Pharoah, Paul P D" uniqKey="Pharoah P" first="Paul P D" last="Pharoah">Paul P D. Pharoah</name><affiliation><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation><nlm:aff id="A61"> Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Pankratz, V Shane" sort="Pankratz, V Shane" uniqKey="Pankratz V" first="V Shane" last="Pankratz">V Shane Pankratz</name><affiliation><nlm:aff id="A3"> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><affiliation><nlm:aff id="A132"> Center for Applied Genomics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="A6"> Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F" last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J" last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="A2"> Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20852631</idno><idno type="pmc">3130795</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130795</idno><idno type="RBID">PMC:3130795</idno><idno type="doi">10.1038/ng.669</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">001557</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001557</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A locus on 19p13 modifies risk of breast cancer in <italic>BRCA1</italic> mutation carriers and is associated with hormone receptor–negative breast cancer in the general population</title><author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C" last="Antoniou">Antonis C. Antoniou</name><affiliation><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><nlm:aff id="A2"> Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Fredericksen, Zachary S" sort="Fredericksen, Zachary S" uniqKey="Fredericksen Z" first="Zachary S" last="Fredericksen">Zachary S. Fredericksen</name><affiliation><nlm:aff id="A3"> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name><affiliation><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Tarrell, Robert" sort="Tarrell, Robert" uniqKey="Tarrell R" first="Robert" last="Tarrell">Robert Tarrell</name><affiliation><nlm:aff id="A3"> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M" last="Sinilnikova">Olga M. Sinilnikova</name><affiliation><nlm:aff id="A4"> Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="A5"> Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name><affiliation><nlm:aff id="A6"> Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Morrison, Jonathan" sort="Morrison, Jonathan" uniqKey="Morrison J" first="Jonathan" last="Morrison">Jonathan Morrison</name><affiliation><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Kartsonaki, Christiana" sort="Kartsonaki, Christiana" uniqKey="Kartsonaki C" first="Christiana" last="Kartsonaki">Christiana Kartsonaki</name><affiliation><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Lesnick, Timothy" sort="Lesnick, Timothy" uniqKey="Lesnick T" first="Timothy" last="Lesnick">Timothy Lesnick</name><affiliation><nlm:aff id="A3"> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Ghoussaini, Maya" sort="Ghoussaini, Maya" uniqKey="Ghoussaini M" first="Maya" last="Ghoussaini">Maya Ghoussaini</name><affiliation><nlm:aff id="A6"> Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Barrowdale, Daniel" sort="Barrowdale, Daniel" uniqKey="Barrowdale D" first="Daniel" last="Barrowdale">Daniel Barrowdale</name><affiliation><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Peock, Susan" sort="Peock, Susan" uniqKey="Peock S" first="Susan" last="Peock">Susan Peock</name><affiliation><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Cook, Margaret" sort="Cook, Margaret" uniqKey="Cook M" first="Margaret" last="Cook">Margaret Cook</name><affiliation><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Oliver, Clare" sort="Oliver, Clare" uniqKey="Oliver C" first="Clare" last="Oliver">Clare Oliver</name><affiliation><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Frost, Debra" sort="Frost, Debra" uniqKey="Frost D" first="Debra" last="Frost">Debra Frost</name><affiliation><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Eccles, Diana" sort="Eccles, Diana" uniqKey="Eccles D" first="Diana" last="Eccles">Diana Eccles</name><affiliation><nlm:aff id="A7"> Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK</nlm:aff></affiliation></author><author><name sortKey="Evans, D Gareth" sort="Evans, D Gareth" uniqKey="Evans D" first="D Gareth" last="Evans">D Gareth Evans</name><affiliation><nlm:aff id="A8"> Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals National Health Service (NHSFT) Foundation Trust, Manchester, UK</nlm:aff></affiliation></author><author><name sortKey="Eeles, Ros" sort="Eeles, Ros" uniqKey="Eeles R" first="Ros" last="Eeles">Ros Eeles</name><affiliation><nlm:aff id="A9"> Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK</nlm:aff></affiliation></author><author><name sortKey="Izatt, Louise" sort="Izatt, Louise" uniqKey="Izatt L" first="Louise" last="Izatt">Louise Izatt</name><affiliation><nlm:aff id="A10"> Clinical Genetics, Guy’s and St. Thomas’ NHS Foundation Trust, London, UK</nlm:aff></affiliation></author><author><name sortKey="Chu, Carol" sort="Chu, Carol" uniqKey="Chu C" first="Carol" last="Chu">Carol Chu</name><affiliation><nlm:aff id="A11"> Yorkshire Regional Genetics Service, Leeds, UK</nlm:aff></affiliation></author><author><name sortKey="Douglas, Fiona" sort="Douglas, Fiona" uniqKey="Douglas F" first="Fiona" last="Douglas">Fiona Douglas</name><affiliation><nlm:aff id="A12"> Institute of Human Genetics, Centre for Life, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK</nlm:aff></affiliation></author><author><name sortKey="Paterson, Joan" sort="Paterson, Joan" uniqKey="Paterson J" first="Joan" last="Paterson">Joan Paterson</name><affiliation><nlm:aff id="A13"> Department of Clinical Genetics, East Anglian Regional Genetics Service, Addenbrookes Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><affiliation><nlm:aff id="A14"> INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Houdayer, Claude" sort="Houdayer, Claude" uniqKey="Houdayer C" first="Claude" last="Houdayer">Claude Houdayer</name><affiliation><nlm:aff id="A14"> INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name><affiliation><nlm:aff id="A5"> Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Giraud, Sophie" sort="Giraud, Sophie" uniqKey="Giraud S" first="Sophie" last="Giraud">Sophie Giraud</name><affiliation><nlm:aff id="A4"> Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Lasset, Christine" sort="Lasset, Christine" uniqKey="Lasset C" first="Christine" last="Lasset">Christine Lasset</name><affiliation><nlm:aff id="A15"> CNRS UMR5558, Université Lyon 1, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="A16"> Unité de Prévention et d’Epidémiologie Génétique, Centre Léon Bérard, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Remenieras, Audrey" sort="Remenieras, Audrey" uniqKey="Remenieras A" first="Audrey" last="Remenieras">Audrey Remenieras</name><affiliation><nlm:aff id="A17"> Genetics Department, Institut de Cancérologie Gustave Roussy, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Caron, Olivier" sort="Caron, Olivier" uniqKey="Caron O" first="Olivier" last="Caron">Olivier Caron</name><affiliation><nlm:aff id="A18"> Consultation de Génétique, Département de Médecine, Institut de Cancérologie Gustave Roussy, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Hardouin, Agnes" sort="Hardouin, Agnes" uniqKey="Hardouin A" first="Agnès" last="Hardouin">Agnès Hardouin</name><affiliation><nlm:aff id="A19"> Centre François Baclesse, Caen, France</nlm:aff></affiliation></author><author><name sortKey="Berthet, Pascaline" sort="Berthet, Pascaline" uniqKey="Berthet P" first="Pascaline" last="Berthet">Pascaline Berthet</name><affiliation><nlm:aff id="A19"> Centre François Baclesse, Caen, France</nlm:aff></affiliation></author><author><name sortKey="Hogervorst, Frans B L" sort="Hogervorst, Frans B L" uniqKey="Hogervorst F" first="Frans B L" last="Hogervorst">Frans B L. Hogervorst</name><affiliation><nlm:aff id="A21"> Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Rookus, Matti A" sort="Rookus, Matti A" uniqKey="Rookus M" first="Matti A" last="Rookus">Matti A. Rookus</name><affiliation><nlm:aff id="A22"> Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Jager, Agnes" sort="Jager, Agnes" uniqKey="Jager A" first="Agnes" last="Jager">Agnes Jager</name><affiliation><nlm:aff id="A23"> Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Den Ouweland, Ans" sort="Van Den Ouweland, Ans" uniqKey="Van Den Ouweland A" first="Ans" last="Van Den Ouweland">Ans Van Den Ouweland</name><affiliation><nlm:aff id="A24"> Department of Clinical Genetics, Rotterdam Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hoogerbrugge, Nicoline" sort="Hoogerbrugge, Nicoline" uniqKey="Hoogerbrugge N" first="Nicoline" last="Hoogerbrugge">Nicoline Hoogerbrugge</name><affiliation><nlm:aff id="A25"> Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Der Luijt, Rob B" sort="Van Der Luijt, Rob B" uniqKey="Van Der Luijt R" first="Rob B" last="Van Der Luijt">Rob B. Van Der Luijt</name><affiliation><nlm:aff id="A26"> Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Meijers Heijboer, Hanne" sort="Meijers Heijboer, Hanne" uniqKey="Meijers Heijboer H" first="Hanne" last="Meijers-Heijboer">Hanne Meijers-Heijboer</name><affiliation><nlm:aff id="A27"> Department of Clinical Genetics, Vrije Universiteit (VU) Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Garcia, Encarna B G Mez" sort="Garcia, Encarna B G Mez" uniqKey="Garcia E" first="Encarna B G Mez" last="García">Encarna B G Mez García</name><affiliation><nlm:aff id="A28"> Department of Clinical Genetics, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:aff id="A30"> Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A31"> Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Vreeswijk, Maaike P G" sort="Vreeswijk, Maaike P G" uniqKey="Vreeswijk M" first="Maaike P G" last="Vreeswijk">Maaike P G. Vreeswijk</name><affiliation><nlm:aff id="A32"> Department of Toxicogenetics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="A33"> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="A33"> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Gronwald, Jacek" sort="Gronwald, Jacek" uniqKey="Gronwald J" first="Jacek" last="Gronwald">Jacek Gronwald</name><affiliation><nlm:aff id="A33"> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Huzarski, Tomasz" sort="Huzarski, Tomasz" uniqKey="Huzarski T" first="Tomasz" last="Huzarski">Tomasz Huzarski</name><affiliation><nlm:aff id="A33"> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Byrski, Tomasz" sort="Byrski, Tomasz" uniqKey="Byrski T" first="Tomasz" last="Byrski">Tomasz Byrski</name><affiliation><nlm:aff id="A33"> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="G Rski, Bohdan" sort="G Rski, Bohdan" uniqKey="G Rski B" first="Bohdan" last="G Rski">Bohdan G Rski</name><affiliation><nlm:aff id="A33"> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Cybulski, Cezary" sort="Cybulski, Cezary" uniqKey="Cybulski C" first="Cezary" last="Cybulski">Cezary Cybulski</name><affiliation><nlm:aff id="A33"> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B" last="Spurdle">Amanda B. Spurdle</name><affiliation><nlm:aff id="A6"> Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Holland, Helene" sort="Holland, Helene" uniqKey="Holland H" first="Helene" last="Holland">Helene Holland</name><affiliation><nlm:aff id="A6"> Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E" last="Goldgar">David E. Goldgar</name><affiliation><nlm:aff id="A35"> Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, USA</nlm:aff></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M" last="John">Esther M. John</name><affiliation><nlm:aff id="A36"> Cancer Prevention Institute of California, Stanford University School of Medicine, Stanford, California, USA</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="A37"> The University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa" sort="Southey, Melissa" uniqKey="Southey M" first="Melissa" last="Southey">Melissa Southey</name><affiliation><nlm:aff id="A37"> The University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Buys, Saundra S" sort="Buys, Saundra S" uniqKey="Buys S" first="Saundra S" last="Buys">Saundra S. Buys</name><affiliation><nlm:aff id="A38"> Huntsman Cancer Institute, University of Utah Health Sciences Centre, Salt Lake City, Utah, USA</nlm:aff></affiliation></author><author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B" last="Daly">Mary B. Daly</name><affiliation><nlm:aff id="A39"> Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Terry, Mary Beth" sort="Terry, Mary Beth" uniqKey="Terry M" first="Mary-Beth" last="Terry">Mary-Beth Terry</name><affiliation><nlm:aff id="A40"> Columbia University, New York, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K" last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="A41"> Centre of Familial Breast and Ovarian Cancer, Department of Obstetrics and Gynaecology, University of Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A42"> Centre for Integrated Oncology (CIO), University of Cologne, Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Wappenschmidt, Barbara" sort="Wappenschmidt, Barbara" uniqKey="Wappenschmidt B" first="Barbara" last="Wappenschmidt">Barbara Wappenschmidt</name><affiliation><nlm:aff id="A41"> Centre of Familial Breast and Ovarian Cancer, Department of Obstetrics and Gynaecology, University of Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A42"> Centre for Integrated Oncology (CIO), University of Cologne, Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Engel, Christoph" sort="Engel, Christoph" uniqKey="Engel C" first="Christoph" last="Engel">Christoph Engel</name><affiliation><nlm:aff id="A43"> Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="A44"> Department of Obstetrics and Gynaecology, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Preisler Adams, Sabine" sort="Preisler Adams, Sabine" uniqKey="Preisler Adams S" first="Sabine" last="Preisler-Adams">Sabine Preisler-Adams</name><affiliation><nlm:aff id="A45"> Institute of Human Genetics, University of Muenster, Muenster, Germany</nlm:aff></affiliation></author><author><name sortKey="Arnold, Norbert" sort="Arnold, Norbert" uniqKey="Arnold N" first="Norbert" last="Arnold">Norbert Arnold</name><affiliation><nlm:aff id="A46"> Department of Obstetrics and Gynaecology, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University, Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Niederacher, Dieter" sort="Niederacher, Dieter" uniqKey="Niederacher D" first="Dieter" last="Niederacher">Dieter Niederacher</name><affiliation><nlm:aff id="A47"> Department of Obstetrics and Gynaecology, Division of Molecular Genetics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Dusseldorf, Germany</nlm:aff></affiliation></author><author><name sortKey="Sutter, Christian" sort="Sutter, Christian" uniqKey="Sutter C" first="Christian" last="Sutter">Christian Sutter</name><affiliation><nlm:aff id="A48"> Institute of Human Genetics, Division of Molecular Diagnostics, University Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M" last="Domchek">Susan M. Domchek</name><affiliation><nlm:aff id="A49"> University of Pennsylvania, Philadelphia, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L" last="Nathanson">Katherine L. Nathanson</name><affiliation><nlm:aff id="A49"> University of Pennsylvania, Philadelphia, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Rebbeck, Timothy" sort="Rebbeck, Timothy" uniqKey="Rebbeck T" first="Timothy" last="Rebbeck">Timothy Rebbeck</name><affiliation><nlm:aff id="A49"> University of Pennsylvania, Philadelphia, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Blum, Joanne L" sort="Blum, Joanne L" uniqKey="Blum J" first="Joanne L" last="Blum">Joanne L. Blum</name><affiliation><nlm:aff id="A50"> Baylor-Charles A. Sammons Cancer Center, Dallas, Texas, USA</nlm:aff></affiliation></author><author><name sortKey="Piedmonte, Marion" sort="Piedmonte, Marion" uniqKey="Piedmonte M" first="Marion" last="Piedmonte">Marion Piedmonte</name><affiliation><nlm:aff id="A51"> Gynecology Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Rodriguez, Gustavo C" sort="Rodriguez, Gustavo C" uniqKey="Rodriguez G" first="Gustavo C" last="Rodriguez">Gustavo C. Rodriguez</name><affiliation><nlm:aff id="A52"> Northshore University Health System, Evanston Northwestern Healthcare, Evanston, Illinois, USA</nlm:aff></affiliation></author><author><name sortKey="Wakeley, Katie" sort="Wakeley, Katie" uniqKey="Wakeley K" first="Katie" last="Wakeley">Katie Wakeley</name><affiliation><nlm:aff id="A53"> Tufts University, New England Medical Center, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Boggess, John F" sort="Boggess, John F" uniqKey="Boggess J" first="John F" last="Boggess">John F. Boggess</name><affiliation><nlm:aff id="A54"> University of North Carolina, Chapel Hill, North Carolina, USA</nlm:aff></affiliation></author><author><name sortKey="Basil, Jack" sort="Basil, Jack" uniqKey="Basil J" first="Jack" last="Basil">Jack Basil</name><affiliation><nlm:aff id="A55"> St. Elizabeth Medical Center, Edgewood, Kentucky, USA</nlm:aff></affiliation></author><author><name sortKey="Blank, Stephanie V" sort="Blank, Stephanie V" uniqKey="Blank S" first="Stephanie V" last="Blank">Stephanie V. Blank</name><affiliation><nlm:aff id="A56"> New York University School of Medicine, New York, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name><affiliation><nlm:aff id="A57"> The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel</nlm:aff></affiliation></author><author><name sortKey="Kaufman, Bella" sort="Kaufman, Bella" uniqKey="Kaufman B" first="Bella" last="Kaufman">Bella Kaufman</name><affiliation><nlm:aff id="A58"> Oncology Institute, Sheba Medical Center, Tel-Hashomer, Israel</nlm:aff></affiliation></author><author><name sortKey="Laitman, Yael" sort="Laitman, Yael" uniqKey="Laitman Y" first="Yael" last="Laitman">Yael Laitman</name><affiliation><nlm:aff id="A57"> The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel</nlm:aff></affiliation></author><author><name sortKey="Milgrom, Roni" sort="Milgrom, Roni" uniqKey="Milgrom R" first="Roni" last="Milgrom">Roni Milgrom</name><affiliation><nlm:aff id="A57"> The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L" last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="A59"> Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A60"> Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A61"> Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="A59"> Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Ozcelik, Hilmi" sort="Ozcelik, Hilmi" uniqKey="Ozcelik H" first="Hilmi" last="Ozcelik">Hilmi Ozcelik</name><affiliation><nlm:aff id="A60"> Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Kirchhoff, Tomas" sort="Kirchhoff, Tomas" uniqKey="Kirchhoff T" first="Tomas" last="Kirchhoff">Tomas Kirchhoff</name><affiliation><nlm:aff id="A62"> Clinical Genetics Service, Memorial Hospital, New York, New York, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A63"> Cancer Biology and Genetics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Vijai, Joseph" sort="Vijai, Joseph" uniqKey="Vijai J" first="Joseph" last="Vijai">Joseph Vijai</name><affiliation><nlm:aff id="A62"> Clinical Genetics Service, Memorial Hospital, New York, New York, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A63"> Cancer Biology and Genetics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M" last="Gaudet">Mia M. Gaudet</name><affiliation><nlm:aff id="A64"> Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, New York, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A65"> Department of Obstetrics and Gynecology and Women’s Health, Albert Einstein College of Medicine, New York, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Altshuler, David" sort="Altshuler, David" uniqKey="Altshuler D" first="David" last="Altshuler">David Altshuler</name><affiliation><nlm:aff id="A66"> Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Guiducci, Candace" sort="Guiducci, Candace" uniqKey="Guiducci C" first="Candace" last="Guiducci">Candace Guiducci</name><affiliation><nlm:aff id="A66"> Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Loman, Niklas" sort="Loman, Niklas" uniqKey="Loman N" first="Niklas" last="Loman">Niklas Loman</name><affiliation><nlm:aff id="A68"> Department of Oncology, Lund University, Lund, Sweden</nlm:aff></affiliation></author><author><name sortKey="Harbst, Katja" sort="Harbst, Katja" uniqKey="Harbst K" first="Katja" last="Harbst">Katja Harbst</name><affiliation><nlm:aff id="A68"> Department of Oncology, Lund University, Lund, Sweden</nlm:aff></affiliation></author><author><name sortKey="Rantala, Johanna" sort="Rantala, Johanna" uniqKey="Rantala J" first="Johanna" last="Rantala">Johanna Rantala</name><affiliation><nlm:aff id="A69"> Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Ehrencrona, Hans" sort="Ehrencrona, Hans" uniqKey="Ehrencrona H" first="Hans" last="Ehrencrona">Hans Ehrencrona</name><affiliation><nlm:aff id="A70"> Department of Genetics and Pathology Rudbeck Laboratory, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Gerdes, Anne Marie" sort="Gerdes, Anne Marie" uniqKey="Gerdes A" first="Anne-Marie" last="Gerdes">Anne-Marie Gerdes</name><affiliation><nlm:aff id="A71"> Department of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name><affiliation><nlm:aff id="A72"> Department of Clinical Genetics, Odense University Hospital, Odense, Denmark</nlm:aff></affiliation></author><author><name sortKey="Sunde, Lone" sort="Sunde, Lone" uniqKey="Sunde L" first="Lone" last="Sunde">Lone Sunde</name><affiliation><nlm:aff id="A73"> Department of Clinical Genetics, Aalborg and Aarhus University Hospital, Aaarhus, Denmark</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="A74"> Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A75"> IFOM, Fondazione Istituto Fondazione Italiana per la Ricera sul Cancro (FIRC) di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="A76"> Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name><affiliation><nlm:aff id="A77"> Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Viel, Alessandra" sort="Viel, Alessandra" uniqKey="Viel A" first="Alessandra" last="Viel">Alessandra Viel</name><affiliation><nlm:aff id="A78"> Division of Experimental Oncology, Centro di Riferimento Oncologico (CRO), IRCCS, Aviano (PN), Italy</nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="A74"> Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A75"> IFOM, Fondazione Istituto Fondazione Italiana per la Ricera sul Cancro (FIRC) di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Caldes, Trinidad" sort="Caldes, Trinidad" uniqKey="Caldes T" first="Trinidad" last="Caldes">Trinidad Caldes</name><affiliation><nlm:aff id="A79"> Hospital Clinico San Carlos, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="De La Hoya, Miguel" sort="De La Hoya, Miguel" uniqKey="De La Hoya M" first="Miguel" last="De La Hoya">Miguel De La Hoya</name><affiliation><nlm:aff id="A77"> Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Singer, Christian F" sort="Singer, Christian F" uniqKey="Singer C" first="Christian F" last="Singer">Christian F. Singer</name><affiliation><nlm:aff id="A80"> Department of Obstetrics/Gynocology, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Fink Retter, Anneliese" sort="Fink Retter, Anneliese" uniqKey="Fink Retter A" first="Anneliese" last="Fink-Retter">Anneliese Fink-Retter</name><affiliation><nlm:aff id="A80"> Department of Obstetrics/Gynocology, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H" last="Greene">Mark H. Greene</name><affiliation><nlm:aff id="A81"> Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L" last="Mai">Phuong L. Mai</name><affiliation><nlm:aff id="A81"> Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Loud, Jennifer T" sort="Loud, Jennifer T" uniqKey="Loud J" first="Jennifer T" last="Loud">Jennifer T. Loud</name><affiliation><nlm:aff id="A81"> Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Guidugli, Lucia" sort="Guidugli, Lucia" uniqKey="Guidugli L" first="Lucia" last="Guidugli">Lucia Guidugli</name><affiliation><nlm:aff id="A2"> Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Lindor, Noralane M" sort="Lindor, Noralane M" uniqKey="Lindor N" first="Noralane M" last="Lindor">Noralane M. Lindor</name><affiliation><nlm:aff id="A82"> Medical Genetics, Mayo Clinic Rochester, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Hansen, Thomas V O" sort="Hansen, Thomas V O" uniqKey="Hansen T" first="Thomas V O" last="Hansen">Thomas V O. Hansen</name><affiliation><nlm:aff id="A83"> Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nielsen, Finn C" sort="Nielsen, Finn C" uniqKey="Nielsen F" first="Finn C" last="Nielsen">Finn C. Nielsen</name><affiliation><nlm:aff id="A83"> Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Blanco, Ignacio" sort="Blanco, Ignacio" uniqKey="Blanco I" first="Ignacio" last="Blanco">Ignacio Blanco</name><affiliation><nlm:aff id="A84"> Hereditary Cancer Program, Catalan Institute of Oncology, Gran Via de l’Hospitalet, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Lazaro, Conxi" sort="Lazaro, Conxi" uniqKey="Lazaro C" first="Conxi" last="Lazaro">Conxi Lazaro</name><affiliation><nlm:aff id="A84"> Hereditary Cancer Program, Catalan Institute of Oncology, Gran Via de l’Hospitalet, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Garber, Judy" sort="Garber, Judy" uniqKey="Garber J" first="Judy" last="Garber">Judy Garber</name><affiliation><nlm:aff id="A85"> Dana-Farber Cancer Institute, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Ramus, Susan J" sort="Ramus, Susan J" uniqKey="Ramus S" first="Susan J" last="Ramus">Susan J. Ramus</name><affiliation><nlm:aff id="A86"> Department of Gynaecological Oncology, University College London, Elizabeth Garrett Anderson (EGA) Institute for Women’s Health, London, UK</nlm:aff></affiliation></author><author><name sortKey="Gayther, Simon A" sort="Gayther, Simon A" uniqKey="Gayther S" first="Simon A" last="Gayther">Simon A. Gayther</name><affiliation><nlm:aff id="A86"> Department of Gynaecological Oncology, University College London, Elizabeth Garrett Anderson (EGA) Institute for Women’s Health, London, UK</nlm:aff></affiliation></author><author><name sortKey="Phelan, Catherine" sort="Phelan, Catherine" uniqKey="Phelan C" first="Catherine" last="Phelan">Catherine Phelan</name><affiliation><nlm:aff id="A87"> Women’s College Research Institute, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Narod, Stephen" sort="Narod, Stephen" uniqKey="Narod S" first="Stephen" last="Narod">Stephen Narod</name><affiliation><nlm:aff id="A88"> Department of Epidemiology and Genetics, H. Lee Moffitt Cancer Center, Tampa, Florida, USA</nlm:aff></affiliation></author><author><name sortKey="Szabo, Csilla I" sort="Szabo, Csilla I" uniqKey="Szabo C" first="Csilla I" last="Szabo">Csilla I. Szabo</name><affiliation><nlm:aff id="A2"> Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="A90"> Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name><affiliation><nlm:aff id="A90"> Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="A91"> Helsinki University Central Hospital, Department of Obstetrics and Gynecology, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Heikkinen, Tuomas" sort="Heikkinen, Tuomas" uniqKey="Heikkinen T" first="Tuomas" last="Heikkinen">Tuomas Heikkinen</name><affiliation><nlm:aff id="A91"> Helsinki University Central Hospital, Department of Obstetrics and Gynecology, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Caligo, Maria A" sort="Caligo, Maria A" uniqKey="Caligo M" first="Maria A" last="Caligo">Maria A. Caligo</name><affiliation><nlm:aff id="A92"> Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, Pisa University Hospital, Pisa, Italy</nlm:aff></affiliation></author><author><name sortKey="Beattie, Mary S" sort="Beattie, Mary S" uniqKey="Beattie M" first="Mary S" last="Beattie">Mary S. Beattie</name><affiliation><nlm:aff id="A93"> Department of Medicine, University of California, San Francisco, San Francisco, California, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A94"> Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A95"> Cancer Risk Program, Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco, California, USA</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="A96"> German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K" last="Godwin">Andrew K. Godwin</name><affiliation><nlm:aff id="A39"> Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name><affiliation><nlm:aff id="A97"> Istituto Oncologico Veneto-IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy</nlm:aff></affiliation></author><author><name sortKey="Casella, Cinzia" sort="Casella, Cinzia" uniqKey="Casella C" first="Cinzia" last="Casella">Cinzia Casella</name><affiliation><nlm:aff id="A97"> Istituto Oncologico Veneto-IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy</nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L" last="Neuhausen">Susan L. Neuhausen</name><affiliation><nlm:aff id="A98"> Department of Population Sciences, The Beckman Research Institute of the City of Hope, Duarte, California, USA</nlm:aff></affiliation></author><author><name sortKey="Karlan, Beth Y" sort="Karlan, Beth Y" uniqKey="Karlan B" first="Beth Y" last="Karlan">Beth Y. Karlan</name><affiliation><nlm:aff id="A99"> Women’s Cancer Research Institute at the Samuel Oschin Cancer Institute, Division of Gynecologic Oncology, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A100"> Department of Obstetrics and Gynecology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Tung, Nadine" sort="Tung, Nadine" uniqKey="Tung N" first="Nadine" last="Tung">Nadine Tung</name><affiliation><nlm:aff id="A101"> Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E" last="Toland">Amanda E. Toland</name><affiliation><nlm:aff id="A102"> Comprehensive Cancer Center, Department of Molecular Virology, Immunology and Medical Genetics, Division of Human Genetics, Department of Internal Medicine, Ohio State University, Columbus, Ohio, USA</nlm:aff></affiliation></author><author><name sortKey="Weitzel, Jeffrey" sort="Weitzel, Jeffrey" uniqKey="Weitzel J" first="Jeffrey" last="Weitzel">Jeffrey Weitzel</name><affiliation><nlm:aff id="A103"> Division of Clinical Cancer Genetics, City of Hope Cancer Center, Duarte, California, USA</nlm:aff></affiliation></author><author><name sortKey="Olopade, Olofunmilayo" sort="Olopade, Olofunmilayo" uniqKey="Olopade O" first="Olofunmilayo" last="Olopade">Olofunmilayo Olopade</name><affiliation><nlm:aff id="A104"> University of Chicago Medical Center, Chicago, Illinois, USA</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="A105"> Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Quebec, Québec City, Quebec, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A106"> Université Laval, Centre de recherche du Centre Hospitalier Universitaire de Quebéc (CHUQ), Québec City, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name><affiliation><nlm:aff id="A105"> Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Quebec, Québec City, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Rubinstein, Wendy S" sort="Rubinstein, Wendy S" uniqKey="Rubinstein W" first="Wendy S" last="Rubinstein">Wendy S. Rubinstein</name><affiliation><nlm:aff id="A107"> Northshore University Health System, Evanston, Illinois, USA</nlm:aff></affiliation></author><author><name sortKey="Arason, Adalgeir" sort="Arason, Adalgeir" uniqKey="Arason A" first="Adalgeir" last="Arason">Adalgeir Arason</name><affiliation><nlm:aff id="A108"> Department of Pathology, Landspitali University Hospital, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name><affiliation><nlm:aff id="A109"> QIMR GWAS Collective, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name><affiliation><nlm:aff id="A110"> Clalit Health Services National Cancer Control Center, Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Technion, Haifa, Israel</nlm:aff></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W" last="Montgomery">Grant W. Montgomery</name><affiliation><nlm:aff id="A110"> Clalit Health Services National Cancer Control Center, Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Technion, Haifa, Israel</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="A111"> Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="A112"> Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="A113"> Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A114"> University Tübingen, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff id="A116"> Melbourne Collaborative Cohort Study (MCCS), Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation><nlm:aff id="A116"> Melbourne Collaborative Cohort Study (MCCS), Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="A117"> Institute for Cancer Studies, Department of Oncology, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S" last="Cross">Simon S. Cross</name><affiliation><nlm:aff id="A118"> Academic Unit of Pathology, Department of Neuroscience, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Miron, Penelope" sort="Miron, Penelope" uniqKey="Miron P" first="Penelope" last="Miron">Penelope Miron</name><affiliation><nlm:aff id="A119"> Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Gerty, Sue M" sort="Gerty, Sue M" uniqKey="Gerty S" first="Sue M" last="Gerty">Sue M. Gerty</name><affiliation><nlm:aff id="A7"> Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK</nlm:aff></affiliation></author><author><name sortKey="Tapper, William" sort="Tapper, William" uniqKey="Tapper W" first="William" last="Tapper">William Tapper</name><affiliation><nlm:aff id="A7"> Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK</nlm:aff></affiliation></author><author><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name><affiliation><nlm:aff id="A120"> Molecular Diagnostics Laboratory Institute of Radioisotopes and Radiodiagnostic Products, National Centre for Scientific Research ‘Demokritos’, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Fountzilas, George" sort="Fountzilas, George" uniqKey="Fountzilas G" first="George" last="Fountzilas">George Fountzilas</name><affiliation><nlm:aff id="A121"> Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A122"> Hellenic Cooperative Oncology Group, Greece</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A" last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="A123"> University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W" last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="A124"> University Hospital Erlangen, Department of Gynecology and Obstetrics, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Silva, Isabel Dos Santos" sort="Silva, Isabel Dos Santos" uniqKey="Silva I" first="Isabel Dos Santos" last="Silva">Isabel Dos Santos Silva</name><affiliation><nlm:aff id="A125"> Cancer Research UK Epidemiology and Genetics Group, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="A125"> Cancer Research UK Epidemiology and Genetics Group, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="A126"> Vesalius Research Center (VRC), VIB, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Paridaens, Robert" sort="Paridaens, Robert" uniqKey="Paridaens R" first="Robert" last="Paridaens">Robert Paridaens</name><affiliation><nlm:aff id="A127"> Multidisciplinary Breast Center, University Hospitals Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Rudiger, Thomas" sort="Rudiger, Thomas" uniqKey="Rudiger T" first="Thomas" last="Rüdiger">Thomas Rüdiger</name><affiliation><nlm:aff id="A128"> Institute of Pathology, Städtisches Klinikum Karlsruhe, Karlsruhe, Germany</nlm:aff></affiliation></author><author><name sortKey="Forsti, Asta" sort="Forsti, Asta" uniqKey="Forsti A" first="Asta" last="Försti">Asta Försti</name><affiliation><nlm:aff id="A96"> German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A129"> Center for Primary Health Care Research, University of Lund, Lund, Sweden</nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="A130"> Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation><nlm:aff id="A130"> Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Diasio, Robert B" sort="Diasio, Robert B" uniqKey="Diasio R" first="Robert B" last="Diasio">Robert B. Diasio</name><affiliation><nlm:aff id="A131"> Department of Pharmacology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Lee, Adam M" sort="Lee, Adam M" uniqKey="Lee A" first="Adam M" last="Lee">Adam M. Lee</name><affiliation><nlm:aff id="A131"> Department of Pharmacology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Eckel Passow, Jeanette" sort="Eckel Passow, Jeanette" uniqKey="Eckel Passow J" first="Jeanette" last="Eckel-Passow">Jeanette Eckel-Passow</name><affiliation><nlm:aff id="A3"> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name><affiliation><nlm:aff id="A3"> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Blows, Fiona" sort="Blows, Fiona" uniqKey="Blows F" first="Fiona" last="Blows">Fiona Blows</name><affiliation><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Driver, Kristy" sort="Driver, Kristy" uniqKey="Driver K" first="Kristy" last="Driver">Kristy Driver</name><affiliation><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison" sort="Dunning, Alison" uniqKey="Dunning A" first="Alison" last="Dunning">Alison Dunning</name><affiliation><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul P D" sort="Pharoah, Paul P D" uniqKey="Pharoah P" first="Paul P D" last="Pharoah">Paul P D. Pharoah</name><affiliation><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation><nlm:aff id="A61"> Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Pankratz, V Shane" sort="Pankratz, V Shane" uniqKey="Pankratz V" first="V Shane" last="Pankratz">V Shane Pankratz</name><affiliation><nlm:aff id="A3"> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><affiliation><nlm:aff id="A132"> Center for Applied Genomics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="A6"> Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F" last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A1"> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J" last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="A2"> Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Germline <italic>BRCA1</italic> mutations predispose to breast cancer. To identify genetic modifiers of this risk, we performed a genome-wide association study in 1,193 individuals with <italic>BRCA1</italic> mutations who were diagnosed with invasive breast cancer under age 40 and 1,190 <italic>BRCA1</italic> carriers without breast cancer diagnosis over age 35. We took forward 96 SNPs for replication in another 5,986 <italic>BRCA1</italic> carriers (2,974 individuals with breast cancer and 3,012 unaffected individuals). Five SNPs on 19p13 were associated with breast cancer risk (<italic>P</italic><sub>trend</sub> = 2.3 × 10<sup>−9</sup> to <italic>P</italic><sub>trend</sub> = 3.9 × 10<sup>−7</sup>), two of which showed independent associations (rs8170, hazard ratio (HR) = 1.26, 95% CI 1.17–1.35; rs2363956 HR = 0.84, 95% CI 0.80–0.89). Genotyping these SNPs in 6,800 population-based breast cancer cases and 6,613 controls identified a similar association with estrogen receptor–negative breast cancer (rs2363956 per-allele odds ratio (OR) = 0.83, 95% CI 0.75–0.92, <italic>P</italic><sub>trend</sub> = 0.0003) and an association with estrogen receptor–positive disease in the opposite direction (OR = 1.07, 95% CI 1.01–1.14, <italic>P</italic><sub>trend</sub> = 0.016). The five SNPs were also associated with triple-negative breast cancer in a separate study of 2,301 triple-negative cases and 3,949 controls (<italic>P</italic><sub>trend</sub> = 1 × 10<sup>−7</sup> to <italic>P</italic><sub>trend</sub> = 8 × 10<sup>−5</sup>; rs2363956 per-allele OR = 0.80, 95% CI 0.74–0.87, <italic>P</italic><sub>trend</sub> = 1.1 × 10<sup>−7</sup>).</p></div></front></TEI><pmc article-type="research-article" xml:lang="en"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9216904</journal-id><journal-id journal-id-type="pubmed-jr-id">2419</journal-id><journal-id journal-id-type="nlm-ta">Nat Genet</journal-id><journal-title-group><journal-title>Nature genetics</journal-title></journal-title-group><issn pub-type="ppub">1061-4036</issn><issn pub-type="epub">1546-1718</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20852631</article-id><article-id pub-id-type="pmc">3130795</article-id><article-id pub-id-type="doi">10.1038/ng.669</article-id><article-id pub-id-type="manuscript">NIHMS287057</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>A locus on 19p13 modifies risk of breast cancer in <italic>BRCA1</italic> mutation carriers and is associated with hormone receptor–negative breast cancer in the general population</article-title></title-group><contrib-group><contrib 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contrib-type="author"><name><surname>Healey</surname><given-names>Sue</given-names></name><xref rid="A6" ref-type="aff">6</xref></contrib><contrib contrib-type="author"><name><surname>Morrison</surname><given-names>Jonathan</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Kartsonaki</surname><given-names>Christiana</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Lesnick</surname><given-names>Timothy</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Ghoussaini</surname><given-names>Maya</given-names></name><xref rid="A6" ref-type="aff">6</xref></contrib><contrib contrib-type="author"><name><surname>Barrowdale</surname><given-names>Daniel</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><collab>EMBRACE</collab><xref rid="A1" 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contrib-type="author"><name><surname>Eeles</surname><given-names>Ros</given-names></name><xref rid="A9" ref-type="aff">9</xref></contrib><contrib contrib-type="author"><name><surname>Izatt</surname><given-names>Louise</given-names></name><xref rid="A10" ref-type="aff">10</xref></contrib><contrib contrib-type="author"><name><surname>Chu</surname><given-names>Carol</given-names></name><xref rid="A11" ref-type="aff">11</xref></contrib><contrib contrib-type="author"><name><surname>Douglas</surname><given-names>Fiona</given-names></name><xref rid="A12" ref-type="aff">12</xref></contrib><contrib contrib-type="author"><name><surname>Paterson</surname><given-names>Joan</given-names></name><xref rid="A13" ref-type="aff">13</xref></contrib><contrib contrib-type="author"><name><surname>Stoppa-Lyonnet</surname><given-names>Dominique</given-names></name><xref rid="A14" ref-type="aff">14</xref></contrib><contrib 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contrib-type="author"><name><surname>Hardouin</surname><given-names>Agnès</given-names></name><xref rid="A19" ref-type="aff">19</xref></contrib><contrib contrib-type="author"><name><surname>Berthet</surname><given-names>Pascaline</given-names></name><xref rid="A19" ref-type="aff">19</xref></contrib><contrib contrib-type="author"><collab>GEMO Study Collaborators</collab><xref rid="A20" ref-type="aff">20</xref><xref rid="FN2" ref-type="author-notes">133</xref></contrib><contrib contrib-type="author"><name><surname>Hogervorst</surname><given-names>Frans B L</given-names></name><xref rid="A21" ref-type="aff">21</xref></contrib><contrib contrib-type="author"><name><surname>Rookus</surname><given-names>Matti A</given-names></name><xref rid="A22" ref-type="aff">22</xref></contrib><contrib contrib-type="author"><name><surname>Jager</surname><given-names>Agnes</given-names></name><xref rid="A23" ref-type="aff">23</xref></contrib><contrib contrib-type="author"><name><surname>van den 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contrib-type="author"><name><surname>Devilee</surname><given-names>Peter</given-names></name><xref rid="A30" ref-type="aff">30</xref><xref rid="A31" ref-type="aff">31</xref></contrib><contrib contrib-type="author"><name><surname>Vreeswijk</surname><given-names>Maaike P G</given-names></name><xref rid="A32" ref-type="aff">32</xref></contrib><contrib contrib-type="author"><name><surname>Lubinski</surname><given-names>Jan</given-names></name><xref rid="A33" ref-type="aff">33</xref></contrib><contrib contrib-type="author"><name><surname>Jakubowska</surname><given-names>Anna</given-names></name><xref rid="A33" ref-type="aff">33</xref></contrib><contrib contrib-type="author"><name><surname>Gronwald</surname><given-names>Jacek</given-names></name><xref rid="A33" ref-type="aff">33</xref></contrib><contrib contrib-type="author"><name><surname>Huzarski</surname><given-names>Tomasz</given-names></name><xref rid="A33" ref-type="aff">33</xref></contrib><contrib contrib-type="author"><name><surname>Byrski</surname><given-names>Tomasz</given-names></name><xref rid="A33" ref-type="aff">33</xref></contrib><contrib contrib-type="author"><name><surname>Górski</surname><given-names>Bohdan</given-names></name><xref rid="A33" ref-type="aff">33</xref></contrib><contrib contrib-type="author"><name><surname>Cybulski</surname><given-names>Cezary</given-names></name><xref rid="A33" ref-type="aff">33</xref></contrib><contrib contrib-type="author"><name><surname>Spurdle</surname><given-names>Amanda B</given-names></name><xref rid="A6" ref-type="aff">6</xref></contrib><contrib contrib-type="author"><name><surname>Holland</surname><given-names>Helene</given-names></name><xref rid="A6" ref-type="aff">6</xref></contrib><contrib contrib-type="author"><collab>kConFab</collab><xref rid="A34" ref-type="aff">34</xref><xref rid="FN2" ref-type="author-notes">133</xref></contrib><contrib contrib-type="author"><name><surname>Goldgar</surname><given-names>David E</given-names></name><xref rid="A35" ref-type="aff">35</xref></contrib><contrib contrib-type="author"><name><surname>John</surname><given-names>Esther M</given-names></name><xref rid="A36" ref-type="aff">36</xref></contrib><contrib contrib-type="author"><name><surname>Hopper</surname><given-names>John L</given-names></name><xref rid="A37" ref-type="aff">37</xref></contrib><contrib contrib-type="author"><name><surname>Southey</surname><given-names>Melissa</given-names></name><xref rid="A37" ref-type="aff">37</xref></contrib><contrib contrib-type="author"><name><surname>Buys</surname><given-names>Saundra S</given-names></name><xref rid="A38" ref-type="aff">38</xref></contrib><contrib contrib-type="author"><name><surname>Daly</surname><given-names>Mary B</given-names></name><xref rid="A39" ref-type="aff">39</xref></contrib><contrib contrib-type="author"><name><surname>Terry</surname><given-names>Mary-Beth</given-names></name><xref rid="A40" ref-type="aff">40</xref></contrib><contrib contrib-type="author"><name><surname>Schmutzler</surname><given-names>Rita K</given-names></name><xref rid="A41" ref-type="aff">41</xref><xref rid="A42" ref-type="aff">42</xref></contrib><contrib contrib-type="author"><name><surname>Wappenschmidt</surname><given-names>Barbara</given-names></name><xref rid="A41" ref-type="aff">41</xref><xref rid="A42" ref-type="aff">42</xref></contrib><contrib contrib-type="author"><name><surname>Engel</surname><given-names>Christoph</given-names></name><xref rid="A43" ref-type="aff">43</xref></contrib><contrib contrib-type="author"><name><surname>Meindl</surname><given-names>Alfons</given-names></name><xref rid="A44" ref-type="aff">44</xref></contrib><contrib contrib-type="author"><name><surname>Preisler-Adams</surname><given-names>Sabine</given-names></name><xref rid="A45" ref-type="aff">45</xref></contrib><contrib contrib-type="author"><name><surname>Arnold</surname><given-names>Norbert</given-names></name><xref rid="A46" ref-type="aff">46</xref></contrib><contrib contrib-type="author"><name><surname>Niederacher</surname><given-names>Dieter</given-names></name><xref rid="A47" ref-type="aff">47</xref></contrib><contrib contrib-type="author"><name><surname>Sutter</surname><given-names>Christian</given-names></name><xref rid="A48" ref-type="aff">48</xref></contrib><contrib contrib-type="author"><name><surname>Domchek</surname><given-names>Susan M</given-names></name><xref rid="A49" ref-type="aff">49</xref></contrib><contrib contrib-type="author"><name><surname>Nathanson</surname><given-names>Katherine L</given-names></name><xref rid="A49" ref-type="aff">49</xref></contrib><contrib contrib-type="author"><name><surname>Rebbeck</surname><given-names>Timothy</given-names></name><xref rid="A49" ref-type="aff">49</xref></contrib><contrib contrib-type="author"><name><surname>Blum</surname><given-names>Joanne L</given-names></name><xref rid="A50" ref-type="aff">50</xref></contrib><contrib contrib-type="author"><name><surname>Piedmonte</surname><given-names>Marion</given-names></name><xref rid="A51" ref-type="aff">51</xref></contrib><contrib contrib-type="author"><name><surname>Rodriguez</surname><given-names>Gustavo C</given-names></name><xref rid="A52" ref-type="aff">52</xref></contrib><contrib contrib-type="author"><name><surname>Wakeley</surname><given-names>Katie</given-names></name><xref rid="A53" ref-type="aff">53</xref></contrib><contrib contrib-type="author"><name><surname>Boggess</surname><given-names>John F</given-names></name><xref rid="A54" ref-type="aff">54</xref></contrib><contrib contrib-type="author"><name><surname>Basil</surname><given-names>Jack</given-names></name><xref rid="A55" ref-type="aff">55</xref></contrib><contrib contrib-type="author"><name><surname>Blank</surname><given-names>Stephanie V</given-names></name><xref rid="A56" ref-type="aff">56</xref></contrib><contrib contrib-type="author"><name><surname>Friedman</surname><given-names>Eitan</given-names></name><xref rid="A57" ref-type="aff">57</xref></contrib><contrib contrib-type="author"><name><surname>Kaufman</surname><given-names>Bella</given-names></name><xref rid="A58" ref-type="aff">58</xref></contrib><contrib contrib-type="author"><name><surname>Laitman</surname><given-names>Yael</given-names></name><xref rid="A57" ref-type="aff">57</xref></contrib><contrib contrib-type="author"><name><surname>Milgrom</surname><given-names>Roni</given-names></name><xref rid="A57" ref-type="aff">57</xref></contrib><contrib contrib-type="author"><name><surname>Andrulis</surname><given-names>Irene L</given-names></name><xref rid="A59" ref-type="aff">59</xref><xref rid="A60" ref-type="aff">60</xref><xref rid="A61" ref-type="aff">61</xref></contrib><contrib contrib-type="author"><name><surname>Glendon</surname><given-names>Gord</given-names></name><xref rid="A59" ref-type="aff">59</xref></contrib><contrib contrib-type="author"><name><surname>Ozcelik</surname><given-names>Hilmi</given-names></name><xref rid="A60" ref-type="aff">60</xref></contrib><contrib contrib-type="author"><name><surname>Kirchhoff</surname><given-names>Tomas</given-names></name><xref rid="A62" ref-type="aff">62</xref><xref rid="A63" ref-type="aff">63</xref></contrib><contrib contrib-type="author"><name><surname>Vijai</surname><given-names>Joseph</given-names></name><xref rid="A62" ref-type="aff">62</xref><xref rid="A63" ref-type="aff">63</xref></contrib><contrib contrib-type="author"><name><surname>Gaudet</surname><given-names>Mia M</given-names></name><xref rid="A64" ref-type="aff">64</xref><xref rid="A65" ref-type="aff">65</xref></contrib><contrib contrib-type="author"><name><surname>Altshuler</surname><given-names>David</given-names></name><xref rid="A66" ref-type="aff">66</xref></contrib><contrib contrib-type="author"><name><surname>Guiducci</surname><given-names>Candace</given-names></name><xref rid="A66" ref-type="aff">66</xref></contrib><contrib contrib-type="author"><collab>SWE-BRCA</collab><xref rid="A67" ref-type="aff">67</xref><xref rid="FN2" ref-type="author-notes">133</xref></contrib><contrib contrib-type="author"><name><surname>Loman</surname><given-names>Niklas</given-names></name><xref rid="A68" ref-type="aff">68</xref></contrib><contrib contrib-type="author"><name><surname>Harbst</surname><given-names>Katja</given-names></name><xref rid="A68" ref-type="aff">68</xref></contrib><contrib contrib-type="author"><name><surname>Rantala</surname><given-names>Johanna</given-names></name><xref rid="A69" ref-type="aff">69</xref></contrib><contrib contrib-type="author"><name><surname>Ehrencrona</surname><given-names>Hans</given-names></name><xref rid="A70" ref-type="aff">70</xref></contrib><contrib contrib-type="author"><name><surname>Gerdes</surname><given-names>Anne-Marie</given-names></name><xref rid="A71" ref-type="aff">71</xref></contrib><contrib contrib-type="author"><name><surname>Thomassen</surname><given-names>Mads</given-names></name><xref rid="A72" ref-type="aff">72</xref></contrib><contrib contrib-type="author"><name><surname>Sunde</surname><given-names>Lone</given-names></name><xref rid="A73" ref-type="aff">73</xref></contrib><contrib contrib-type="author"><name><surname>Peterlongo</surname><given-names>Paolo</given-names></name><xref rid="A74" ref-type="aff">74</xref><xref rid="A75" ref-type="aff">75</xref></contrib><contrib contrib-type="author"><name><surname>Manoukian</surname><given-names>Siranoush</given-names></name><xref rid="A76" ref-type="aff">76</xref></contrib><contrib contrib-type="author"><name><surname>Bonanni</surname><given-names>Bernardo</given-names></name><xref rid="A77" ref-type="aff">77</xref></contrib><contrib contrib-type="author"><name><surname>Viel</surname><given-names>Alessandra</given-names></name><xref rid="A78" ref-type="aff">78</xref></contrib><contrib contrib-type="author"><name><surname>Radice</surname><given-names>Paolo</given-names></name><xref rid="A74" ref-type="aff">74</xref><xref rid="A75" ref-type="aff">75</xref></contrib><contrib contrib-type="author"><name><surname>Caldes</surname><given-names>Trinidad</given-names></name><xref rid="A79" ref-type="aff">79</xref></contrib><contrib contrib-type="author"><name><surname>de la Hoya</surname><given-names>Miguel</given-names></name><xref rid="A77" ref-type="aff">77</xref></contrib><contrib contrib-type="author"><name><surname>Singer</surname><given-names>Christian F</given-names></name><xref rid="A80" ref-type="aff">80</xref></contrib><contrib contrib-type="author"><name><surname>Fink-Retter</surname><given-names>Anneliese</given-names></name><xref rid="A80" ref-type="aff">80</xref></contrib><contrib contrib-type="author"><name><surname>Greene</surname><given-names>Mark H</given-names></name><xref rid="A81" ref-type="aff">81</xref></contrib><contrib contrib-type="author"><name><surname>Mai</surname><given-names>Phuong L</given-names></name><xref rid="A81" ref-type="aff">81</xref></contrib><contrib contrib-type="author"><name><surname>Loud</surname><given-names>Jennifer T</given-names></name><xref rid="A81" ref-type="aff">81</xref></contrib><contrib contrib-type="author"><name><surname>Guidugli</surname><given-names>Lucia</given-names></name><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Lindor</surname><given-names>Noralane M</given-names></name><xref rid="A82" ref-type="aff">82</xref></contrib><contrib contrib-type="author"><name><surname>Hansen</surname><given-names>Thomas V O</given-names></name><xref rid="A83" ref-type="aff">83</xref></contrib><contrib contrib-type="author"><name><surname>Nielsen</surname><given-names>Finn C</given-names></name><xref rid="A83" ref-type="aff">83</xref></contrib><contrib contrib-type="author"><name><surname>Blanco</surname><given-names>Ignacio</given-names></name><xref rid="A84" ref-type="aff">84</xref></contrib><contrib contrib-type="author"><name><surname>Lazaro</surname><given-names>Conxi</given-names></name><xref rid="A84" ref-type="aff">84</xref></contrib><contrib contrib-type="author"><name><surname>Garber</surname><given-names>Judy</given-names></name><xref rid="A85" ref-type="aff">85</xref></contrib><contrib contrib-type="author"><name><surname>Ramus</surname><given-names>Susan J</given-names></name><xref rid="A86" ref-type="aff">86</xref></contrib><contrib contrib-type="author"><name><surname>Gayther</surname><given-names>Simon A</given-names></name><xref rid="A86" ref-type="aff">86</xref></contrib><contrib contrib-type="author"><name><surname>Phelan</surname><given-names>Catherine</given-names></name><xref rid="A87" ref-type="aff">87</xref></contrib><contrib contrib-type="author"><name><surname>Narod</surname><given-names>Stephen</given-names></name><xref rid="A88" ref-type="aff">88</xref></contrib><contrib contrib-type="author"><name><surname>Szabo</surname><given-names>Csilla I</given-names></name><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><collab>MOD SQUAD</collab><xref rid="A89" ref-type="aff">89</xref><xref rid="FN2" ref-type="author-notes">133</xref></contrib><contrib contrib-type="author"><name><surname>Benitez</surname><given-names>Javier</given-names></name><xref rid="A90" ref-type="aff">90</xref></contrib><contrib contrib-type="author"><name><surname>Osorio</surname><given-names>Ana</given-names></name><xref rid="A90" ref-type="aff">90</xref></contrib><contrib contrib-type="author"><name><surname>Nevanlinna</surname><given-names>Heli</given-names></name><xref rid="A91" ref-type="aff">91</xref></contrib><contrib contrib-type="author"><name><surname>Heikkinen</surname><given-names>Tuomas</given-names></name><xref rid="A91" ref-type="aff">91</xref></contrib><contrib contrib-type="author"><name><surname>Caligo</surname><given-names>Maria A</given-names></name><xref rid="A92" ref-type="aff">92</xref></contrib><contrib contrib-type="author"><name><surname>Beattie</surname><given-names>Mary S</given-names></name><xref rid="A93" ref-type="aff">93</xref><xref rid="A94" ref-type="aff">94</xref><xref rid="A95" ref-type="aff">95</xref></contrib><contrib contrib-type="author"><name><surname>Hamann</surname><given-names>Ute</given-names></name><xref rid="A96" ref-type="aff">96</xref></contrib><contrib contrib-type="author"><name><surname>Godwin</surname><given-names>Andrew K</given-names></name><xref rid="A39" ref-type="aff">39</xref></contrib><contrib contrib-type="author"><name><surname>Montagna</surname><given-names>Marco</given-names></name><xref rid="A97" ref-type="aff">97</xref></contrib><contrib contrib-type="author"><name><surname>Casella</surname><given-names>Cinzia</given-names></name><xref rid="A97" ref-type="aff">97</xref></contrib><contrib contrib-type="author"><name><surname>Neuhausen</surname><given-names>Susan L</given-names></name><xref rid="A98" ref-type="aff">98</xref></contrib><contrib contrib-type="author"><name><surname>Karlan</surname><given-names>Beth Y</given-names></name><xref rid="A99" ref-type="aff">99</xref><xref rid="A100" ref-type="aff">100</xref></contrib><contrib contrib-type="author"><name><surname>Tung</surname><given-names>Nadine</given-names></name><xref rid="A101" ref-type="aff">101</xref></contrib><contrib contrib-type="author"><name><surname>Toland</surname><given-names>Amanda E</given-names></name><xref rid="A102" ref-type="aff">102</xref></contrib><contrib contrib-type="author"><name><surname>Weitzel</surname><given-names>Jeffrey</given-names></name><xref rid="A103" ref-type="aff">103</xref></contrib><contrib contrib-type="author"><name><surname>Olopade</surname><given-names>Olofunmilayo</given-names></name><xref rid="A104" ref-type="aff">104</xref></contrib><contrib contrib-type="author"><name><surname>Simard</surname><given-names>Jacques</given-names></name><xref rid="A105" ref-type="aff">105</xref><xref rid="A106" ref-type="aff">106</xref></contrib><contrib contrib-type="author"><name><surname>Soucy</surname><given-names>Penny</given-names></name><xref rid="A105" ref-type="aff">105</xref></contrib><contrib contrib-type="author"><name><surname>Rubinstein</surname><given-names>Wendy S</given-names></name><xref rid="A107" ref-type="aff">107</xref></contrib><contrib contrib-type="author"><name><surname>Arason</surname><given-names>Adalgeir</given-names></name><xref rid="A108" ref-type="aff">108</xref></contrib><contrib contrib-type="author"><name><surname>Rennert</surname><given-names>Gad</given-names></name><xref rid="A109" ref-type="aff">109</xref></contrib><contrib contrib-type="author"><name><surname>Martin</surname><given-names>Nicholas G</given-names></name><xref rid="A110" ref-type="aff">110</xref></contrib><contrib contrib-type="author"><name><surname>Montgomery</surname><given-names>Grant W</given-names></name><xref rid="A110" ref-type="aff">110</xref></contrib><contrib contrib-type="author"><name><surname>Chang-Claude</surname><given-names>Jenny</given-names></name><xref rid="A111" ref-type="aff">111</xref></contrib><contrib contrib-type="author"><name><surname>Flesch-Janys</surname><given-names>Dieter</given-names></name><xref rid="A112" ref-type="aff">112</xref></contrib><contrib contrib-type="author"><name><surname>Brauch</surname><given-names>Hiltrud</given-names></name><xref rid="A113" ref-type="aff">113</xref><xref rid="A114" ref-type="aff">114</xref></contrib><contrib contrib-type="author"><collab>GENICA</collab><xref rid="A115" ref-type="aff">115</xref><xref rid="FN2" ref-type="author-notes">133</xref></contrib><contrib contrib-type="author"><name><surname>Severi</surname><given-names>Gianluca</given-names></name><xref rid="A116" ref-type="aff">116</xref></contrib><contrib contrib-type="author"><name><surname>Baglietto</surname><given-names>Laura</given-names></name><xref rid="A116" ref-type="aff">116</xref></contrib><contrib contrib-type="author"><name><surname>Cox</surname><given-names>Angela</given-names></name><xref rid="A117" ref-type="aff">117</xref></contrib><contrib contrib-type="author"><name><surname>Cross</surname><given-names>Simon S</given-names></name><xref rid="A118" ref-type="aff">118</xref></contrib><contrib contrib-type="author"><name><surname>Miron</surname><given-names>Penelope</given-names></name><xref rid="A119" ref-type="aff">119</xref></contrib><contrib contrib-type="author"><name><surname>Gerty</surname><given-names>Sue M</given-names></name><xref rid="A7" ref-type="aff">7</xref></contrib><contrib contrib-type="author"><name><surname>Tapper</surname><given-names>William</given-names></name><xref rid="A7" ref-type="aff">7</xref></contrib><contrib contrib-type="author"><name><surname>Yannoukakos</surname><given-names>Drakoulis</given-names></name><xref rid="A120" ref-type="aff">120</xref></contrib><contrib contrib-type="author"><name><surname>Fountzilas</surname><given-names>George</given-names></name><xref rid="A121" ref-type="aff">121</xref><xref rid="A122" ref-type="aff">122</xref></contrib><contrib contrib-type="author"><name><surname>Fasching</surname><given-names>Peter A</given-names></name><xref rid="A123" ref-type="aff">123</xref></contrib><contrib contrib-type="author"><name><surname>Beckmann</surname><given-names>Matthias W</given-names></name><xref rid="A124" ref-type="aff">124</xref></contrib><contrib contrib-type="author"><name><surname>Silva</surname><given-names>Isabel dos Santos</given-names></name><xref rid="A125" ref-type="aff">125</xref></contrib><contrib contrib-type="author"><name><surname>Peto</surname><given-names>Julian</given-names></name><xref rid="A125" ref-type="aff">125</xref></contrib><contrib contrib-type="author"><name><surname>Lambrechts</surname><given-names>Diether</given-names></name><xref rid="A126" ref-type="aff">126</xref></contrib><contrib contrib-type="author"><name><surname>Paridaens</surname><given-names>Robert</given-names></name><xref rid="A127" ref-type="aff">127</xref></contrib><contrib contrib-type="author"><name><surname>Rüdiger</surname><given-names>Thomas</given-names></name><xref rid="A128" ref-type="aff">128</xref></contrib><contrib contrib-type="author"><name><surname>Försti</surname><given-names>Asta</given-names></name><xref rid="A96" ref-type="aff">96</xref><xref rid="A129" ref-type="aff">129</xref></contrib><contrib contrib-type="author"><name><surname>Winqvist</surname><given-names>Robert</given-names></name><xref rid="A130" ref-type="aff">130</xref></contrib><contrib contrib-type="author"><name><surname>Pylkäs</surname><given-names>Katri</given-names></name><xref rid="A130" ref-type="aff">130</xref></contrib><contrib contrib-type="author"><name><surname>Diasio</surname><given-names>Robert B</given-names></name><xref rid="A131" ref-type="aff">131</xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Adam M</given-names></name><xref rid="A131" ref-type="aff">131</xref></contrib><contrib contrib-type="author"><name><surname>Eckel-Passow</surname><given-names>Jeanette</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Vachon</surname><given-names>Celine</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Blows</surname><given-names>Fiona</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Driver</surname><given-names>Kristy</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Dunning</surname><given-names>Alison</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Pharoah</surname><given-names>Paul P D</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Offit</surname><given-names>Kenneth</given-names></name><xref rid="A61" ref-type="aff">61</xref></contrib><contrib contrib-type="author"><name><surname>Pankratz</surname><given-names>V Shane</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Hakonarson</surname><given-names>Hakon</given-names></name><xref rid="A132" ref-type="aff">132</xref></contrib><contrib contrib-type="author"><name><surname>Chenevix-Trench</surname><given-names>Georgia</given-names></name><xref rid="A6" ref-type="aff">6</xref></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas F</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Couch</surname><given-names>Fergus J</given-names></name><xref rid="A2" ref-type="aff">2</xref></contrib></contrib-group><aff id="A1"><label>1</label> Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</aff><aff id="A2"><label>2</label> Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</aff><aff id="A3"><label>3</label> Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</aff><aff id="A4"><label>4</label> Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard, Lyon, France</aff><aff id="A5"><label>5</label> Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France</aff><aff id="A6"><label>6</label> Queensland Institute of Medical Research, Brisbane, Australia</aff><aff id="A7"><label>7</label> Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK</aff><aff id="A8"><label>8</label> Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals National Health Service (NHSFT) Foundation Trust, Manchester, UK</aff><aff id="A9"><label>9</label> Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK</aff><aff id="A10"><label>10</label> Clinical Genetics, Guy’s and St. Thomas’ NHS Foundation Trust, London, UK</aff><aff id="A11"><label>11</label> Yorkshire Regional Genetics Service, Leeds, UK</aff><aff id="A12"><label>12</label> Institute of Human Genetics, Centre for Life, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK</aff><aff id="A13"><label>13</label> Department of Clinical Genetics, East Anglian Regional Genetics Service, Addenbrookes Hospital, Cambridge, UK</aff><aff id="A14"><label>14</label> INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes, Paris, France</aff><aff id="A15"><label>15</label> CNRS UMR5558, Université Lyon 1, Lyon, France</aff><aff id="A16"><label>16</label> Unité de Prévention et d’Epidémiologie Génétique, Centre Léon Bérard, Lyon, France</aff><aff id="A17"><label>17</label> Genetics Department, Institut de Cancérologie Gustave Roussy, Villejuif, France</aff><aff id="A18"><label>18</label> Consultation de Génétique, Département de Médecine, Institut de Cancérologie Gustave Roussy, Villejuif, France</aff><aff id="A19"><label>19</label> Centre François Baclesse, Caen, France</aff><aff id="A20"><label>20</label> GEMO study, Cancer Genetics Network ‘Groupe Génétique et Cancer’, Fédération Nationale des Centres de Lutte Contre le Cancer, Paris, France</aff><aff id="A21"><label>21</label> Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, The Netherlands</aff><aff id="A22"><label>22</label> Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</aff><aff id="A23"><label>23</label> Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="A24"><label>24</label> Department of Clinical Genetics, Rotterdam Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="A25"><label>25</label> Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</aff><aff id="A26"><label>26</label> Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</aff><aff id="A27"><label>27</label> Department of Clinical Genetics, Vrije Universiteit (VU) Medical Center, Amsterdam, The Netherlands</aff><aff id="A28"><label>28</label> Department of Clinical Genetics, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands</aff><aff id="A29"><label>29</label> HEBON, Hereditary Breast and Ovarian Cancer Research Group, The Netherlands</aff><aff id="A30"><label>30</label> Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</aff><aff id="A31"><label>31</label> Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands</aff><aff id="A32"><label>32</label> Department of Toxicogenetics, Leiden University Medical Center, Leiden, The Netherlands</aff><aff id="A33"><label>33</label> International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</aff><aff id="A34"><label>34</label> kConFab, Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, Peter MacCallum Cancer Centre, Melbourne, Australia</aff><aff id="A35"><label>35</label> Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, USA</aff><aff id="A36"><label>36</label> Cancer Prevention Institute of California, Stanford University School of Medicine, Stanford, California, USA</aff><aff id="A37"><label>37</label> The University of Melbourne, Melbourne, Australia</aff><aff id="A38"><label>38</label> Huntsman Cancer Institute, University of Utah Health Sciences Centre, Salt Lake City, Utah, USA</aff><aff id="A39"><label>39</label> Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA</aff><aff id="A40"><label>40</label> Columbia University, New York, New York, USA</aff><aff id="A41"><label>41</label> Centre of Familial Breast and Ovarian Cancer, Department of Obstetrics and Gynaecology, University of Cologne, Cologne, Germany</aff><aff id="A42"><label>42</label> Centre for Integrated Oncology (CIO), University of Cologne, Cologne, Germany</aff><aff id="A43"><label>43</label> Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany</aff><aff id="A44"><label>44</label> Department of Obstetrics and Gynaecology, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Munich, Germany</aff><aff id="A45"><label>45</label> Institute of Human Genetics, University of Muenster, Muenster, Germany</aff><aff id="A46"><label>46</label> Department of Obstetrics and Gynaecology, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University, Kiel, Germany</aff><aff id="A47"><label>47</label> Department of Obstetrics and Gynaecology, Division of Molecular Genetics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Dusseldorf, Germany</aff><aff id="A48"><label>48</label> Institute of Human Genetics, Division of Molecular Diagnostics, University Heidelberg, Heidelberg, Germany</aff><aff id="A49"><label>49</label> University of Pennsylvania, Philadelphia, Pennsylvania, USA</aff><aff id="A50"><label>50</label> Baylor-Charles A. Sammons Cancer Center, Dallas, Texas, USA</aff><aff id="A51"><label>51</label> Gynecology Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, New York, USA</aff><aff id="A52"><label>52</label> Northshore University Health System, Evanston Northwestern Healthcare, Evanston, Illinois, USA</aff><aff id="A53"><label>53</label> Tufts University, New England Medical Center, Boston, Massachusetts, USA</aff><aff id="A54"><label>54</label> University of North Carolina, Chapel Hill, North Carolina, USA</aff><aff id="A55"><label>55</label> St. Elizabeth Medical Center, Edgewood, Kentucky, USA</aff><aff id="A56"><label>56</label> New York University School of Medicine, New York, New York, USA</aff><aff id="A57"><label>57</label> The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel</aff><aff id="A58"><label>58</label> Oncology Institute, Sheba Medical Center, Tel-Hashomer, Israel</aff><aff id="A59"><label>59</label> Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada</aff><aff id="A60"><label>60</label> Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</aff><aff id="A61"><label>61</label> Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</aff><aff id="A62"><label>62</label> Clinical Genetics Service, Memorial Hospital, New York, New York, USA</aff><aff id="A63"><label>63</label> Cancer Biology and Genetics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, USA</aff><aff id="A64"><label>64</label> Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, New York, USA</aff><aff id="A65"><label>65</label> Department of Obstetrics and Gynecology and Women’s Health, Albert Einstein College of Medicine, New York, New York, USA</aff><aff id="A66"><label>66</label> Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA</aff><aff id="A67"><label>67</label> SWE-BRCA, Swedish Breast Cancer Study, Sweden</aff><aff id="A68"><label>68</label> Department of Oncology, Lund University, Lund, Sweden</aff><aff id="A69"><label>69</label> Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden</aff><aff id="A70"><label>70</label> Department of Genetics and Pathology Rudbeck Laboratory, Uppsala University, Uppsala, Sweden</aff><aff id="A71"><label>71</label> Department of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark</aff><aff id="A72"><label>72</label> Department of Clinical Genetics, Odense University Hospital, Odense, Denmark</aff><aff id="A73"><label>73</label> Department of Clinical Genetics, Aalborg and Aarhus University Hospital, Aaarhus, Denmark</aff><aff id="A74"><label>74</label> Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale Tumori (INT), Milan, Italy</aff><aff id="A75"><label>75</label> IFOM, Fondazione Istituto Fondazione Italiana per la Ricera sul Cancro (FIRC) di Oncologia Molecolare, Milan, Italy</aff><aff id="A76"><label>76</label> Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy</aff><aff id="A77"><label>77</label> Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy</aff><aff id="A78"><label>78</label> Division of Experimental Oncology, Centro di Riferimento Oncologico (CRO), IRCCS, Aviano (PN), Italy</aff><aff id="A79"><label>79</label> Hospital Clinico San Carlos, Madrid, Spain</aff><aff id="A80"><label>80</label> Department of Obstetrics/Gynocology, Medical University of Vienna, Vienna, Austria</aff><aff id="A81"><label>81</label> Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA</aff><aff id="A82"><label>82</label> Medical Genetics, Mayo Clinic Rochester, Rochester, Minnesota, USA</aff><aff id="A83"><label>83</label> Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark</aff><aff id="A84"><label>84</label> Hereditary Cancer Program, Catalan Institute of Oncology, Gran Via de l’Hospitalet, Barcelona, Spain</aff><aff id="A85"><label>85</label> Dana-Farber Cancer Institute, Boston, Massachusetts, USA</aff><aff id="A86"><label>86</label> Department of Gynaecological Oncology, University College London, Elizabeth Garrett Anderson (EGA) Institute for Women’s Health, London, UK</aff><aff id="A87"><label>87</label> Women’s College Research Institute, Toronto, Ontario, Canada</aff><aff id="A88"><label>88</label> Department of Epidemiology and Genetics, H. Lee Moffitt Cancer Center, Tampa, Florida, USA</aff><aff id="A89"><label>89</label> MOD SQUAD, Modifier Study of Quantitative Effects on Disease</aff><aff id="A90"><label>90</label> Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain</aff><aff id="A91"><label>91</label> Helsinki University Central Hospital, Department of Obstetrics and Gynecology, Helsinki, Finland</aff><aff id="A92"><label>92</label> Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, Pisa University Hospital, Pisa, Italy</aff><aff id="A93"><label>93</label> Department of Medicine, University of California, San Francisco, San Francisco, California, USA</aff><aff id="A94"><label>94</label> Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA</aff><aff id="A95"><label>95</label> Cancer Risk Program, Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco, California, USA</aff><aff id="A96"><label>96</label> German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A97"><label>97</label> Istituto Oncologico Veneto-IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy</aff><aff id="A98"><label>98</label> Department of Population Sciences, The Beckman Research Institute of the City of Hope, Duarte, California, USA</aff><aff id="A99"><label>99</label> Women’s Cancer Research Institute at the Samuel Oschin Cancer Institute, Division of Gynecologic Oncology, Cedars-Sinai Medical Center, Los Angeles, California, USA</aff><aff id="A100"><label>100</label> Department of Obstetrics and Gynecology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California, USA</aff><aff id="A101"><label>101</label> Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA</aff><aff id="A102"><label>102</label> Comprehensive Cancer Center, Department of Molecular Virology, Immunology and Medical Genetics, Division of Human Genetics, Department of Internal Medicine, Ohio State University, Columbus, Ohio, USA</aff><aff id="A103"><label>103</label> Division of Clinical Cancer Genetics, City of Hope Cancer Center, Duarte, California, USA</aff><aff id="A104"><label>104</label> University of Chicago Medical Center, Chicago, Illinois, USA</aff><aff id="A105"><label>105</label> Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Quebec, Québec City, Quebec, Canada</aff><aff id="A106"><label>106</label> Université Laval, Centre de recherche du Centre Hospitalier Universitaire de Quebéc (CHUQ), Québec City, Quebec, Canada</aff><aff id="A107"><label>107</label> Northshore University Health System, Evanston, Illinois, USA</aff><aff id="A108"><label>108</label> Department of Pathology, Landspitali University Hospital, Reykjavik, Iceland</aff><aff id="A109"><label>109</label> QIMR GWAS Collective, Queensland Institute of Medical Research, Brisbane, Australia</aff><aff id="A110"><label>110</label> Clalit Health Services National Cancer Control Center, Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Technion, Haifa, Israel</aff><aff id="A111"><label>111</label> Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A112"><label>112</label> Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</aff><aff id="A113"><label>113</label> Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</aff><aff id="A114"><label>114</label> University Tübingen, Tübingen, Germany</aff><aff id="A115"><label>115</label> GENICA, Gene Environment Interaction and Breast Cancer in Germany</aff><aff id="A116"><label>116</label> Melbourne Collaborative Cohort Study (MCCS), Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</aff><aff id="A117"><label>117</label> Institute for Cancer Studies, Department of Oncology, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK</aff><aff id="A118"><label>118</label> Academic Unit of Pathology, Department of Neuroscience, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK</aff><aff id="A119"><label>119</label> Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA</aff><aff id="A120"><label>120</label> Molecular Diagnostics Laboratory Institute of Radioisotopes and Radiodiagnostic Products, National Centre for Scientific Research ‘Demokritos’, Athens, Greece</aff><aff id="A121"><label>121</label> Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece</aff><aff id="A122"><label>122</label> Hellenic Cooperative Oncology Group, Greece</aff><aff id="A123"><label>123</label> University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, Los Angeles, California, USA</aff><aff id="A124"><label>124</label> University Hospital Erlangen, Department of Gynecology and Obstetrics, Erlangen, Germany</aff><aff id="A125"><label>125</label> Cancer Research UK Epidemiology and Genetics Group, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK</aff><aff id="A126"><label>126</label> Vesalius Research Center (VRC), VIB, Leuven, Belgium</aff><aff id="A127"><label>127</label> Multidisciplinary Breast Center, University Hospitals Leuven, Leuven, Belgium</aff><aff id="A128"><label>128</label> Institute of Pathology, Städtisches Klinikum Karlsruhe, Karlsruhe, Germany</aff><aff id="A129"><label>129</label> Center for Primary Health Care Research, University of Lund, Lund, Sweden</aff><aff id="A130"><label>130</label> Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu, Finland</aff><aff id="A131"><label>131</label> Department of Pharmacology, Mayo Clinic, Rochester, Minnesota, USA</aff><aff id="A132"><label>132</label> Center for Applied Genomics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA</aff><author-notes><corresp id="FN1">Correspondence should be addressed to F.J.C. (<email>couch.fergus@mayo.edu</email>)</corresp><fn id="FN2"><label>133</label><p>A full list of members is provided in the <xref rid="SD1" ref-type="supplementary-material">supplementary Note</xref>.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>7</day><month>4</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>19</day><month>9</month><year>2010</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>10</month><year>2011</year></pub-date><volume>42</volume><issue>10</issue><fpage>885</fpage><lpage>892</lpage><permissions><copyright-statement>© 2010 Nature America, Inc. All rights reserved.</copyright-statement><copyright-year>2010</copyright-year></permissions><abstract><p id="P1">Germline <italic>BRCA1</italic> mutations predispose to breast cancer. To identify genetic modifiers of this risk, we performed a genome-wide association study in 1,193 individuals with <italic>BRCA1</italic> mutations who were diagnosed with invasive breast cancer under age 40 and 1,190 <italic>BRCA1</italic> carriers without breast cancer diagnosis over age 35. We took forward 96 SNPs for replication in another 5,986 <italic>BRCA1</italic> carriers (2,974 individuals with breast cancer and 3,012 unaffected individuals). Five SNPs on 19p13 were associated with breast cancer risk (<italic>P</italic><sub>trend</sub> = 2.3 × 10<sup>−9</sup> to <italic>P</italic><sub>trend</sub> = 3.9 × 10<sup>−7</sup>), two of which showed independent associations (rs8170, hazard ratio (HR) = 1.26, 95% CI 1.17–1.35; rs2363956 HR = 0.84, 95% CI 0.80–0.89). Genotyping these SNPs in 6,800 population-based breast cancer cases and 6,613 controls identified a similar association with estrogen receptor–negative breast cancer (rs2363956 per-allele odds ratio (OR) = 0.83, 95% CI 0.75–0.92, <italic>P</italic><sub>trend</sub> = 0.0003) and an association with estrogen receptor–positive disease in the opposite direction (OR = 1.07, 95% CI 1.01–1.14, <italic>P</italic><sub>trend</sub> = 0.016). The five SNPs were also associated with triple-negative breast cancer in a separate study of 2,301 triple-negative cases and 3,949 controls (<italic>P</italic><sub>trend</sub> = 1 × 10<sup>−7</sup> to <italic>P</italic><sub>trend</sub> = 8 × 10<sup>−5</sup>; rs2363956 per-allele OR = 0.80, 95% CI 0.74–0.87, <italic>P</italic><sub>trend</sub> = 1.1 × 10<sup>−7</sup>).</p></abstract><funding-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>U01 CA069638-14 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>U01 CA069631-14 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>U01 CA069467-14 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>U01 CA069446-14 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>U01 CA069417-14 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>U01 CA069398-14 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R01 CA128978-03 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R01 CA122340-03 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R01 CA074415-10 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>P50 CA116201-05 || CA</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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