Common variants in FKBP5 gene and major depressive disorder (MDD) susceptibility: a comprehensive meta-analysis
Identifieur interne : 000A63 ( Pmc/Checkpoint ); précédent : 000A62; suivant : 000A64Common variants in FKBP5 gene and major depressive disorder (MDD) susceptibility: a comprehensive meta-analysis
Auteurs : Shuquan Rao [République populaire de Chine] ; Yao Yao [République populaire de Chine] ; Joanne Ryan [Australie, France] ; Tao Li [République populaire de Chine] ; Duan Wang [République populaire de Chine] ; Chuan Zheng [République populaire de Chine] ; Yong Xu [République populaire de Chine] ; Qi Xu [République populaire de Chine]Source :
- Scientific Reports [ 2045-2322 ] ; 2016.
Abstract
Previous studies have investigated the association between common variants in
Url:
DOI: 10.1038/srep32687
PubMed: 27601205
PubMed Central: 5013409
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Common variants in <italic>FKBP5</italic> gene and major depressive disorder (MDD) susceptibility: a comprehensive meta-analysis</title><author><name sortKey="Rao, Shuquan" sort="Rao, Shuquan" uniqKey="Rao S" first="Shuquan" last="Rao">Shuquan Rao</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>School of Life Science and Engineering, Southwest Jiaotong University</institution>, Chengdu 610031,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yao, Yao" sort="Yao, Yao" uniqKey="Yao Y" first="Yao" last="Yao">Yao Yao</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine</institution>, Chengdu 611137,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ryan, Joanne" sort="Ryan, Joanne" uniqKey="Ryan J" first="Joanne" last="Ryan">Joanne Ryan</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Disease Epigenetics Group, Murdoch Childrens Research Institute & Department of Paediatrics, University of Melbourne</institution>, 3052 Parkville, Victoria,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Inserm, U1061, Univ Montpellier</institution>, F-34093 Montpellier,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, Tao" sort="Li, Tao" uniqKey="Li T" first="Tao" last="Li">Tao Li</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Mental Health Center, West China Hospital/West China School of Medicine, Sichuan University</institution>, Chengdu, 610041,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Duan" sort="Wang, Duan" uniqKey="Wang D" first="Duan" last="Wang">Duan Wang</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Department of Orthopedics, West China Hospital/West China School of Medicine, Sichuan University</institution>, Chengdu, 610041,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zheng, Chuan" sort="Zheng, Chuan" uniqKey="Zheng C" first="Chuan" last="Zheng">Chuan Zheng</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine</institution>, Chengdu 611137,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Yong" sort="Xu, Yong" uniqKey="Xu Y" first="Yong" last="Xu">Yong Xu</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Psychiatry, First Clinical Medical College/First Hospital of Shanxi Medical University</institution>, Taiyuan, 030000,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Qi" sort="Xu, Qi" uniqKey="Xu Q" first="Qi" last="Xu">Qi Xu</name><affiliation wicri:level="1"><nlm:aff id="a8"><institution>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College</institution>, Beijing 10005,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27601205</idno><idno type="pmc">5013409</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013409</idno><idno type="RBID">PMC:5013409</idno><idno type="doi">10.1038/srep32687</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000842</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000842</idno><idno type="wicri:Area/Pmc/Curation">000841</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000841</idno><idno type="wicri:Area/Pmc/Checkpoint">000A63</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A63</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Common variants in <italic>FKBP5</italic> gene and major depressive disorder (MDD) susceptibility: a comprehensive meta-analysis</title><author><name sortKey="Rao, Shuquan" sort="Rao, Shuquan" uniqKey="Rao S" first="Shuquan" last="Rao">Shuquan Rao</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>School of Life Science and Engineering, Southwest Jiaotong University</institution>, Chengdu 610031,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yao, Yao" sort="Yao, Yao" uniqKey="Yao Y" first="Yao" last="Yao">Yao Yao</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine</institution>, Chengdu 611137,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ryan, Joanne" sort="Ryan, Joanne" uniqKey="Ryan J" first="Joanne" last="Ryan">Joanne Ryan</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Disease Epigenetics Group, Murdoch Childrens Research Institute & Department of Paediatrics, University of Melbourne</institution>, 3052 Parkville, Victoria,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Inserm, U1061, Univ Montpellier</institution>, F-34093 Montpellier,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, Tao" sort="Li, Tao" uniqKey="Li T" first="Tao" last="Li">Tao Li</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Mental Health Center, West China Hospital/West China School of Medicine, Sichuan University</institution>, Chengdu, 610041,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Duan" sort="Wang, Duan" uniqKey="Wang D" first="Duan" last="Wang">Duan Wang</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Department of Orthopedics, West China Hospital/West China School of Medicine, Sichuan University</institution>, Chengdu, 610041,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zheng, Chuan" sort="Zheng, Chuan" uniqKey="Zheng C" first="Chuan" last="Zheng">Chuan Zheng</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine</institution>, Chengdu 611137,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Yong" sort="Xu, Yong" uniqKey="Xu Y" first="Yong" last="Xu">Yong Xu</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Psychiatry, First Clinical Medical College/First Hospital of Shanxi Medical University</institution>, Taiyuan, 030000,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Qi" sort="Xu, Qi" uniqKey="Xu Q" first="Qi" last="Xu">Qi Xu</name><affiliation wicri:level="1"><nlm:aff id="a8"><institution>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College</institution>, Beijing 10005,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Previous studies have investigated the association between common variants in <italic>FKBP5</italic> and MDD; however, the results remain inconsistent. In order to conduct a comprehensive meta-analysis of the association between <italic>FKBP5</italic> variants and MDD risk, seven studies involving 26582 subjects, including 12491 cases with MDD and 14091 controls, were enrolled totally. Four common SNPs (rs1360780, rs4713916, rs3800373 and rs755658) with complete data from two or more studies were analyzed. In the total sample, there was no evidence of a significant association between MDD and any of the four SNPs using a random-effects model. However, after removing one heterogeneous German study, as indicated by sensitivity analysis, both the rs1360780 T-allele (Z = 2.95, <italic>P</italic> = 0.003, OR = 1.06, 95% CI = 1.02–1.11) and the rs3800373 C-allele (Z = 3.05, <italic>P</italic> = 0.002, OR = 1.07, 95% CI 1.02–1.12) were significantly associated with MDD in a fixed-effect model. Our study thus provides support for an association between specific <italic>FKBP5</italic> genetic variants and MDD risk. Rs4713916 was not significantly associated with MDD; However, this analysis had limited statistical power and larger sample sizes are required to further validate this result. Future research should also investigate possible gender- and ethnicity-specific differences in the association between FKBP5 and MDD.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Alonso, J" uniqKey="Alonso J">J. Alonso</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murray, C J" uniqKey="Murray C">C. J. Murray</name></author><author><name sortKey="Lopez, A D" uniqKey="Lopez A">A. D. Lopez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sullivan, P F" uniqKey="Sullivan P">P. F. Sullivan</name></author><author><name sortKey="Neale, M C" uniqKey="Neale M">M. C. Neale</name></author><author><name sortKey="Kendler, K S" uniqKey="Kendler K">K. S. Kendler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shih, R A" uniqKey="Shih R">R. A. Shih</name></author><author><name sortKey="Belmonte, P L" uniqKey="Belmonte P">P. L. Belmonte</name></author><author><name sortKey="Zandi, P P" uniqKey="Zandi P">P. P. Zandi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sullivan, P F" uniqKey="Sullivan P">P. F. Sullivan</name></author><author><name sortKey="Daly, M J" uniqKey="Daly M">M. J. Daly</name></author><author><name sortKey="O Onovan, M" uniqKey="O Onovan M">M. O’Donovan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wray, N R" uniqKey="Wray N">N. R. Wray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Consortium, C" uniqKey="Consortium C">C. consortium</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Kloet, E R" uniqKey="De Kloet E">E. R. de Kloet</name></author><author><name sortKey="Joels, M" uniqKey="Joels M">M. Joels</name></author><author><name sortKey="Holsboer, F" uniqKey="Holsboer F">F. Holsboer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levinson, D F" uniqKey="Levinson D">D. F. Levinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verhagen, M" uniqKey="Verhagen M">M. Verhagen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheng, R" uniqKey="Cheng R">R. Cheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grad, I" uniqKey="Grad I">I. Grad</name></author><author><name sortKey="Picard, D" uniqKey="Picard D">D. Picard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wochnik, G M" uniqKey="Wochnik G">G. M. Wochnik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Binder, E B" uniqKey="Binder E">E. B. Binder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lekman, M" uniqKey="Lekman M">M. Lekman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zobel, A" uniqKey="Zobel A">A. Zobel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Szczepankiewicz, A" uniqKey="Szczepankiewicz A">A. Szczepankiewicz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Papiol, S" uniqKey="Papiol S">S. Papiol</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lavebratt, C" uniqKey="Lavebratt C">C. Lavebratt</name></author><author><name sortKey="Aberg, E" uniqKey="Aberg E">E. Aberg</name></author><author><name sortKey="Sjoholm, L K" uniqKey="Sjoholm L">L. K. Sjoholm</name></author><author><name sortKey="Forsell, Y" uniqKey="Forsell Y">Y. Forsell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Minelli, A" uniqKey="Minelli A">A. Minelli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chapman, K" uniqKey="Chapman K">K. Chapman</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Rao, S" uniqKey="Rao S">S. Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Flint, J" uniqKey="Flint J">J. Flint</name></author><author><name sortKey="Kendler, K S" uniqKey="Kendler K">K. S. Kendler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spencer, C C" uniqKey="Spencer C">C. C. Spencer</name></author><author><name sortKey="Su, Z" uniqKey="Su Z">Z. Su</name></author><author><name sortKey="Donnelly, P" uniqKey="Donnelly P">P. Donnelly</name></author><author><name sortKey="Marchini, J" uniqKey="Marchini J">J. Marchini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, M" uniqKey="Li M">M. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, M" uniqKey="Li M">M. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, L" uniqKey="Wang L">L. Wang</name></author><author><name sortKey="Shi, C" uniqKey="Shi C">C. Shi</name></author><author><name sortKey="Zhang, K" uniqKey="Zhang K">K. Zhang</name></author><author><name sortKey="Xu, Q" uniqKey="Xu Q">Q. Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, X" uniqKey="Zhang X">X. Zhang</name></author><author><name sortKey="Clark, A F" uniqKey="Clark A">A. F. Clark</name></author><author><name sortKey="Yorio, T" uniqKey="Yorio T">T. Yorio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kawamura, Y" uniqKey="Kawamura Y">Y. Kawamura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yao, Y" uniqKey="Yao Y">Y. Yao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rietschel, M" uniqKey="Rietschel M">M. Rietschel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sullivan, P F" uniqKey="Sullivan P">P. F. Sullivan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shi, J" uniqKey="Shi J">J. Shi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muglia, P" uniqKey="Muglia P">P. Muglia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lewis, C M" uniqKey="Lewis C">C. M. Lewis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shyn, S I" uniqKey="Shyn S">S. I. Shyn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ising, M" uniqKey="Ising M">M. Ising</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dupont, W D" uniqKey="Dupont W">W. D. Dupont</name></author><author><name sortKey="Plummer, W D" uniqKey="Plummer W">W. D. Plummer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Egger, M" uniqKey="Egger M">M. Egger</name></author><author><name sortKey="Davey Smith, G" uniqKey="Davey Smith G">G. Davey Smith</name></author><author><name sortKey="Schneider, M" uniqKey="Schneider M">M. Schneider</name></author><author><name sortKey="Minder, C" uniqKey="Minder C">C. Minder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Begg, C B" uniqKey="Begg C">C. B. Begg</name></author><author><name sortKey="Mazumdar, M" uniqKey="Mazumdar M">M. Mazumdar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, J" uniqKey="Lau J">J. Lau</name></author><author><name sortKey="Ioannidis, J P" uniqKey="Ioannidis J">J. P. Ioannidis</name></author><author><name sortKey="Schmid, C H" uniqKey="Schmid C">C. H. Schmid</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Sci Rep</journal-id><journal-id journal-id-type="iso-abbrev">Sci Rep</journal-id><journal-title-group><journal-title>Scientific Reports</journal-title></journal-title-group><issn pub-type="epub">2045-2322</issn><publisher><publisher-name>Nature Publishing Group</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27601205</article-id><article-id pub-id-type="pmc">5013409</article-id><article-id pub-id-type="pii">srep32687</article-id><article-id pub-id-type="doi">10.1038/srep32687</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Common variants in <italic>FKBP5</italic> gene and major depressive disorder (MDD) susceptibility: a comprehensive meta-analysis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Rao</surname><given-names>Shuquan</given-names></name><xref ref-type="corresp" rid="c1">a</xref><xref ref-type="aff" rid="a1">1</xref><xref ref-type="author-notes" rid="n1">*</xref></contrib><contrib contrib-type="author"><name><surname>Yao</surname><given-names>Yao</given-names></name><xref ref-type="aff" rid="a2">2</xref><xref ref-type="author-notes" rid="n1">*</xref></contrib><contrib contrib-type="author"><name><surname>Ryan</surname><given-names>Joanne</given-names></name><xref ref-type="aff" rid="a3">3</xref><xref ref-type="aff" rid="a4">4</xref><xref ref-type="author-notes" rid="n1">*</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Tao</given-names></name><xref ref-type="aff" rid="a5">5</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Duan</given-names></name><xref ref-type="aff" rid="a6">6</xref></contrib><contrib contrib-type="author"><name><surname>Zheng</surname><given-names>Chuan</given-names></name><xref ref-type="aff" rid="a2">2</xref></contrib><contrib contrib-type="author"><name><surname>Xu</surname><given-names>Yong</given-names></name><xref ref-type="aff" rid="a7">7</xref></contrib><contrib contrib-type="author"><name><surname>Xu</surname><given-names>Qi</given-names></name><xref ref-type="corresp" rid="c2">b</xref><xref ref-type="aff" rid="a8">8</xref></contrib><aff id="a1"><label>1</label><institution>School of Life Science and Engineering, Southwest Jiaotong University</institution>, Chengdu 610031,<country>China</country></aff><aff id="a2"><label>2</label><institution>Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine</institution>, Chengdu 611137,<country>China</country></aff><aff id="a3"><label>3</label><institution>Disease Epigenetics Group, Murdoch Childrens Research Institute & Department of Paediatrics, University of Melbourne</institution>, 3052 Parkville, Victoria,<country>Australia</country></aff><aff id="a4"><label>4</label><institution>Inserm, U1061, Univ Montpellier</institution>, F-34093 Montpellier,<country>France</country></aff><aff id="a5"><label>5</label><institution>Mental Health Center, West China Hospital/West China School of Medicine, Sichuan University</institution>, Chengdu, 610041,<country>China</country></aff><aff id="a6"><label>6</label><institution>Department of Orthopedics, West China Hospital/West China School of Medicine, Sichuan University</institution>, Chengdu, 610041,<country>China</country></aff><aff id="a7"><label>7</label><institution>Department of Psychiatry, First Clinical Medical College/First Hospital of Shanxi Medical University</institution>, Taiyuan, 030000,<country>China</country></aff><aff id="a8"><label>8</label><institution>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College</institution>, Beijing 10005,<country>China</country></aff></contrib-group><author-notes><corresp id="c1"><label>a</label><email>shuquan_rao@163.com</email></corresp><corresp id="c2"><label>b</label><email>xuqi@pumc.edu.cn</email></corresp><fn id="n1"><label>*</label><p>These authors contributed equally to this work.</p></fn></author-notes><pub-date pub-type="epub"><day>07</day><month>09</month><year>2016</year></pub-date><pub-date pub-type="collection"><year>2016</year></pub-date><volume>6</volume><elocation-id>32687</elocation-id><history><date date-type="received"><day>24</day><month>02</month><year>2016</year></date><date date-type="accepted"><day>12</day><month>08</month><year>2016</year></date></history><permissions><copyright-statement>Copyright © 2016, The Author(s)</copyright-statement><copyright-year>2016</copyright-year><copyright-holder>The Author(s)</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><pmc-comment>author-paid</pmc-comment>
<license-p>This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link></license-p></license></permissions><abstract><p>Previous studies have investigated the association between common variants in <italic>FKBP5</italic> and MDD; however, the results remain inconsistent. In order to conduct a comprehensive meta-analysis of the association between <italic>FKBP5</italic> variants and MDD risk, seven studies involving 26582 subjects, including 12491 cases with MDD and 14091 controls, were enrolled totally. Four common SNPs (rs1360780, rs4713916, rs3800373 and rs755658) with complete data from two or more studies were analyzed. In the total sample, there was no evidence of a significant association between MDD and any of the four SNPs using a random-effects model. However, after removing one heterogeneous German study, as indicated by sensitivity analysis, both the rs1360780 T-allele (Z = 2.95, <italic>P</italic> = 0.003, OR = 1.06, 95% CI = 1.02–1.11) and the rs3800373 C-allele (Z = 3.05, <italic>P</italic> = 0.002, OR = 1.07, 95% CI 1.02–1.12) were significantly associated with MDD in a fixed-effect model. Our study thus provides support for an association between specific <italic>FKBP5</italic> genetic variants and MDD risk. Rs4713916 was not significantly associated with MDD; However, this analysis had limited statistical power and larger sample sizes are required to further validate this result. Future research should also investigate possible gender- and ethnicity-specific differences in the association between FKBP5 and MDD.</p></abstract></article-meta></front><floats-group><fig id="f1"><label>Figure 1</label><caption><title>Literature search flow chart.</title><p><sup>a</sup>The association result is accessible from Ricopili (<ext-link ext-link-type="uri" xlink:href="http://www.broadinstitute.org/mpg/ricopili/">http://www.broadinstitute.org/mpg/ricopili/</ext-link>). BD, bipolar disorder; PTSD, posttraumatic stress disorder.</p></caption><graphic xlink:href="srep32687-f1"></graphic></fig><fig id="f2"><label>Figure 2</label><caption><title>Forest plot of meta-analysis for rs1360780 T-allele, rs4713916 A-allele, rs3800373 C-allele, and rs755668 T-allele of <italic>FKBP5</italic> gene using fixed-effect model.</title><p>Note: I-V, Inverse-variance; PGC, Psychiatric GWAS Consortium.</p></caption><graphic xlink:href="srep32687-f2"></graphic></fig><table-wrap position="float" id="t1"><label>Table 1</label><caption><title>Characteristics of included studies and samples on the association of <italic>FKBP5</italic> variants and MDD.</title></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col></colgroup><thead valign="bottom"><tr><th rowspan="2" align="left" valign="top" charoff="50">Author, Year</th><th rowspan="2" align="center" valign="top" charoff="50">Ethnicity</th><th colspan="3" align="center" valign="top" charoff="50">MDD cases<hr></hr></th><th colspan="3" align="center" valign="top" charoff="50">Healthy controls<hr></hr></th><th rowspan="2" align="center" valign="top" charoff="50">Definition of MDD</th><th rowspan="2" align="center" valign="top" charoff="50">Genotyping method</th></tr><tr><th align="center" valign="top" charoff="50">N<xref ref-type="fn" rid="t1-fn1">a</xref></th><th align="center" valign="top" charoff="50">Mean age</th><th align="center" valign="top" charoff="50">Gender (% Male)</th><th align="center" valign="top" charoff="50">N<xref ref-type="fn" rid="t1-fn1">a</xref></th><th align="center" valign="top" charoff="50">Mean age</th><th align="center" valign="top" charoff="50">Gender (% Male)</th></tr></thead><tbody valign="top"><tr><td align="left" valign="top" charoff="50">Szczepankiewicz, 2014</td><td align="center" valign="top" charoff="50">Poland</td><td align="center" valign="top" charoff="50">218</td><td align="center" valign="top" charoff="50">45.5 ± 14.0</td><td align="center" valign="top" charoff="50">50 (23.0)</td><td align="center" valign="top" charoff="50">528</td><td align="center" valign="top" charoff="50">37.7 ± 12.5</td><td align="center" valign="top" charoff="50">315 (42.5)</td><td align="center" valign="top" charoff="50">DSM-IV</td><td align="center" valign="top" charoff="50">TaqMan</td></tr><tr><td align="left" valign="top" charoff="50">Minelli 2013</td><td align="center" valign="top" charoff="50">Italy</td><td align="center" valign="top" charoff="50">657</td><td align="center" valign="top" charoff="50">56.1 ± 13.7</td><td align="center" valign="top" charoff="50">210 (32.0)</td><td align="center" valign="top" charoff="50">462</td><td align="center" valign="top" charoff="50">46.7 ± 16.3</td><td align="center" valign="top" charoff="50">203 (43.9)</td><td align="center" valign="top" charoff="50">DSM-IV</td><td align="center" valign="top" charoff="50">Illumina</td></tr><tr><td align="left" valign="top" charoff="50">Zobel 2010</td><td align="center" valign="top" charoff="50">Germany</td><td align="center" valign="top" charoff="50">268</td><td align="center" valign="top" charoff="50">48.9 ± 14.0</td><td align="center" valign="top" charoff="50">98 (36.6)</td><td align="center" valign="top" charoff="50">284</td><td align="center" valign="top" charoff="50">46.5 ± 15.0</td><td align="center" valign="top" charoff="50">115 (40.5)</td><td align="center" valign="top" charoff="50">DSM-IV</td><td align="center" valign="top" charoff="50">TaqMan</td></tr><tr><td align="left" valign="top" charoff="50">Lavebratt 2010</td><td align="center" valign="top" charoff="50">Sweden</td><td align="center" valign="top" charoff="50">431</td><td align="center" valign="top" charoff="50">44.9 ± 12.0</td><td align="center" valign="top" charoff="50">118 (27.3)</td><td align="center" valign="top" charoff="50">2204</td><td align="center" valign="top" charoff="50">45.1 ± 12.1</td><td align="center" valign="top" charoff="50">968 (43.9)</td><td align="center" valign="top" charoff="50">DSM-IV</td><td align="center" valign="top" charoff="50">TaqMan</td></tr><tr><td align="left" valign="top" charoff="50">Lekman 2008</td><td align="center" valign="top" charoff="50">USA</td><td align="center" valign="top" charoff="50">1520</td><td align="center" valign="top" charoff="50">N.A.</td><td align="center" valign="top" charoff="50">N.A.</td><td align="center" valign="top" charoff="50">769</td><td align="center" valign="top" charoff="50">N.A.</td><td align="center" valign="top" charoff="50">N.A.</td><td align="center" valign="top" charoff="50">DSM-IV</td><td align="center" valign="top" charoff="50">Illumina, TaqMan</td></tr><tr><td align="left" valign="top" charoff="50">Papiol 2007</td><td align="center" valign="top" charoff="50">Spain</td><td align="center" valign="top" charoff="50">159</td><td align="center" valign="top" charoff="50">39.5 ± 12.2</td><td align="center" valign="top" charoff="50">35 (22.0)</td><td align="center" valign="top" charoff="50">96</td><td align="center" valign="top" charoff="50">35.1 ± 10.3</td><td align="center" valign="top" charoff="50">55 (57.3)</td><td align="center" valign="top" charoff="50">DSM-IV</td><td align="center" valign="top" charoff="50">TaqMan</td></tr><tr><td align="left" valign="top" charoff="50">Psychiatric GWAS Consortium, 2013</td><td align="center" valign="top" charoff="50">European<xref ref-type="fn" rid="t1-fn2">b</xref></td><td align="center" valign="top" charoff="50">9240</td><td align="center" valign="top" charoff="50"><xref ref-type="fn" rid="t1-fn3">*</xref>See below</td><td align="center" valign="top" charoff="50"><xref ref-type="fn" rid="t1-fn3">*</xref>See below</td><td align="center" valign="top" charoff="50">9519</td><td align="center" valign="top" charoff="50"><xref ref-type="fn" rid="t1-fn3">*</xref>See below</td><td align="center" valign="top" charoff="50"><xref ref-type="fn" rid="t1-fn3">*</xref>See below</td><td align="center" valign="top" charoff="50">DSM-IV</td><td align="center" valign="top" charoff="50">Illumina, Affymetrix</td></tr></tbody></table><table-wrap-foot><fn id="t1-fn1"><p><sup>a</sup>The overall sample recruited in each study.</p></fn><fn id="t1-fn2"><p><sup>b</sup>samples from 9 distinct populations of European ancestry.</p></fn><fn id="t1-fn3"><p><sup>*</sup>This study was a GWAS mega-analysis of MDD and the age and gender information was available in each study, respectively.</p></fn><fn id="t1-fn4"><p>N.A., not available.</p></fn></table-wrap-foot></table-wrap><table-wrap position="float" id="t2"><label>Table 2</label><caption><title>Characteristics of the association studies between 4 SNPs of <italic>FKBP5</italic> included for meta-analysis and MDD.</title></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col></colgroup><thead valign="bottom"><tr><th rowspan="2" align="center" valign="top" charoff="50">SNP (Major/minor allele)</th><th rowspan="2" align="center" valign="top" charoff="50">Position</th><th rowspan="2" align="center" valign="top" charoff="50">Author, year</th><th rowspan="2" align="center" valign="top" charoff="50">Ethinicity</th><th rowspan="2" align="center" valign="top" charoff="50"><xref ref-type="fn" rid="t2-fn1">a</xref>N cases/N controls</th><th colspan="2" align="center" valign="top" charoff="50">Minor allele frequency<hr></hr></th><th rowspan="2" align="center" valign="top" charoff="50"><italic>P</italic>-value</th><th rowspan="2" align="center" valign="top" charoff="50">OR (95% CI)</th></tr><tr><th align="center" valign="top" charoff="50">Cases</th><th align="center" valign="top" charoff="50">Controls</th></tr></thead><tbody valign="top"><tr><td rowspan="7" align="center" valign="middle" charoff="50">rs1360780 (C/T)</td><td rowspan="7" align="center" valign="middle" charoff="50">Chr6: 35639794</td><td align="center" valign="top" charoff="50">Szczepankiewicz, 2014</td><td align="center" valign="top" charoff="50">Poland</td><td align="center" valign="top" charoff="50">218/762</td><td align="center" valign="top" charoff="50">0.280</td><td align="center" valign="top" charoff="50">0.257</td><td align="center" valign="top" charoff="50">0.372</td><td align="center" valign="top" charoff="50">1.121 (0.872–1.442)</td></tr><tr><td align="center" valign="top" charoff="50">Minelli, 2013</td><td align="center" valign="top" charoff="50">Italy</td><td align="center" valign="top" charoff="50">657/462</td><td align="center" valign="top" charoff="50">0.312</td><td align="center" valign="top" charoff="50">0.332</td><td align="center" valign="top" charoff="50">0.313</td><td align="center" valign="top" charoff="50">0.912 (0.761–1.091)</td></tr><tr><td align="center" valign="top" charoff="50">Zobel, 2010</td><td align="center" valign="top" charoff="50">Germany</td><td align="center" valign="top" charoff="50">268/284</td><td align="center" valign="top" charoff="50">0.281</td><td align="center" valign="top" charoff="50">0.339</td><td align="center" valign="top" charoff="50">0.036</td><td align="center" valign="top" charoff="50">0.762 (0.590–0.984)</td></tr><tr><td align="center" valign="top" charoff="50">Lavebratt, 2010</td><td align="center" valign="top" charoff="50">Sweden</td><td align="center" valign="top" charoff="50">431/2204</td><td align="center" valign="top" charoff="50">0.268</td><td align="center" valign="top" charoff="50">0.265</td><td align="center" valign="top" charoff="50">0.844</td><td align="center" valign="top" charoff="50">1.107 (0.862–1.199)</td></tr><tr><td align="center" valign="top" charoff="50">Lekman, 2008</td><td align="center" valign="top" charoff="50">USA</td><td align="center" valign="top" charoff="50">1520/769</td><td align="center" valign="top" charoff="50">0.346</td><td align="center" valign="top" charoff="50">0.304</td><td align="center" valign="top" charoff="50">0.005</td><td align="center" valign="top" charoff="50">1.210 (1.060–1.380)</td></tr><tr><td align="center" valign="top" charoff="50">Papiol, 2007</td><td align="center" valign="top" charoff="50">Spain</td><td align="center" valign="top" charoff="50">157/91</td><td align="center" valign="top" charoff="50">0.334</td><td align="center" valign="top" charoff="50">0.297</td><td align="center" valign="top" charoff="50">0.386</td><td align="center" valign="top" charoff="50">1.191 (0.802–1.768)</td></tr><tr><td align="center" valign="top" charoff="50">Psychiatric GWAS Consortium, 2013</td><td align="center" valign="top" charoff="50"><xref ref-type="fn" rid="t2-fn2">b</xref>European</td><td align="center" valign="top" charoff="50">9240/9519</td><td align="center" valign="top" charoff="50"><xref ref-type="fn" rid="t2-fn3">*</xref>See below</td><td align="center" valign="top" charoff="50"><xref ref-type="fn" rid="t2-fn3">*</xref>See below</td><td align="center" valign="top" charoff="50">0.039</td><td align="center" valign="top" charoff="50">1.049 (1.002–1.098)</td></tr><tr><td rowspan="3" align="center" valign="middle" charoff="50">rs755658 (C/T)</td><td rowspan="3" align="center" valign="middle" charoff="50">Chr6: 35581893</td><td align="center" valign="top" charoff="50">Szczepankiewicz, 2014</td><td align="center" valign="top" charoff="50">Poland</td><td align="center" valign="top" charoff="50">211/520</td><td align="center" valign="top" charoff="50">0.104</td><td align="center" valign="top" charoff="50">0.090</td><td align="center" valign="top" charoff="50">0.411</td><td align="center" valign="top" charoff="50">1.171 (0.803–1.708)</td></tr><tr><td align="center" valign="top" charoff="50">Zobel, 2010</td><td align="center" valign="top" charoff="50">Germany</td><td align="center" valign="top" charoff="50">268/284</td><td align="center" valign="top" charoff="50">0.094</td><td align="center" valign="top" charoff="50">0.122</td><td align="center" valign="top" charoff="50">0.126</td><td align="center" valign="top" charoff="50">0.744 (0.506–1.093)</td></tr><tr><td align="center" valign="top" charoff="50">Psychiatric GWAS Consortium, 2013</td><td align="center" valign="top" charoff="50">European</td><td align="center" valign="top" charoff="50">9240/9519</td><td align="center" valign="top" charoff="50"><xref ref-type="fn" rid="t2-fn3">*</xref>See below</td><td align="center" valign="top" charoff="50"><xref ref-type="fn" rid="t2-fn3">*</xref>See below</td><td align="center" valign="top" charoff="50">0.067</td><td align="center" valign="top" charoff="50">1.068 (0.995–1.146)</td></tr><tr><td rowspan="3" align="center" valign="middle" charoff="50">rs4713916 (G/A)</td><td rowspan="3" align="center" valign="middle" charoff="50">Chr6: 35702206</td><td align="center" valign="top" charoff="50">Szczepankiewicz, 2014</td><td align="center" valign="top" charoff="50">Poland</td><td align="center" valign="top" charoff="50">222/521</td><td align="center" valign="top" charoff="50">0.284</td><td align="center" valign="top" charoff="50">0.258</td><td align="center" valign="top" charoff="50">0.306</td><td align="center" valign="top" charoff="50">1.139 (0.888–1.460)</td></tr><tr><td align="center" valign="top" charoff="50">Zobel, 2010</td><td align="center" valign="top" charoff="50">Germany</td><td align="center" valign="top" charoff="50">268/284</td><td align="center" valign="top" charoff="50">0.273</td><td align="center" valign="top" charoff="50">0.341</td><td align="center" valign="top" charoff="50">0.014</td><td align="center" valign="top" charoff="50">0.722 (0.558–0.934)</td></tr><tr><td align="center" valign="top" charoff="50">Lekman, 2008</td><td align="center" valign="top" charoff="50">USA</td><td align="center" valign="top" charoff="50">1523/739</td><td align="center" valign="top" charoff="50">0.275</td><td align="center" valign="top" charoff="50">0.261</td><td align="center" valign="top" charoff="50">0.322</td><td align="center" valign="top" charoff="50">1.074 (0.933–1.236)</td></tr><tr><td rowspan="4" align="center" valign="middle" charoff="50">rs3800373 (A/C)</td><td rowspan="4" align="center" valign="middle" charoff="50">Chr6: 35574699</td><td align="center" valign="top" charoff="50">Szczepankiewicz, 2014</td><td align="center" valign="top" charoff="50">Poland</td><td align="center" valign="top" charoff="50">220/516</td><td align="center" valign="top" charoff="50">0.255</td><td align="center" valign="top" charoff="50">0.244</td><td align="center" valign="top" charoff="50">0.673</td><td align="center" valign="top" charoff="50">1.057 (0.817–1.367)</td></tr><tr><td align="center" valign="top" charoff="50">Zobel, 2010</td><td align="center" valign="top" charoff="50">Germany</td><td align="center" valign="top" charoff="50">268/284</td><td align="center" valign="top" charoff="50">0.255</td><td align="center" valign="top" charoff="50">0.322</td><td align="center" valign="top" charoff="50">0.014</td><td align="center" valign="top" charoff="50">0.722 (0.556–0.939)</td></tr><tr><td align="center" valign="top" charoff="50">Lekman, 2008</td><td align="center" valign="top" charoff="50">USA</td><td align="center" valign="top" charoff="50">1496/691</td><td align="center" valign="top" charoff="50">0.328</td><td align="center" valign="top" charoff="50">0.298</td><td align="center" valign="top" charoff="50">0.052</td><td align="center" valign="top" charoff="50">1.147 (0.999–1.317)</td></tr><tr><td align="center" valign="top" charoff="50">Psychiatric GWAS Consortium, 2013</td><td align="center" valign="top" charoff="50">European</td><td align="center" valign="top" charoff="50">9240/9519</td><td align="center" valign="top" charoff="50"><xref ref-type="fn" rid="t2-fn3">*</xref>See below</td><td align="center" valign="top" charoff="50"><xref ref-type="fn" rid="t2-fn3">*</xref>See below</td><td align="center" valign="top" charoff="50">0.011</td><td align="center" valign="top" charoff="50">1.062 (1.014–1.113)</td></tr></tbody></table><table-wrap-foot><fn id="t2-fn1"><p><sup>a</sup>The N represents the number of individuals having genotyping data.</p></fn><fn id="t2-fn2"><p><sup>b</sup>samples from 9 distinct populations of European ancestry.</p></fn><fn id="t2-fn3"><p><sup>*</sup>Only the MAF of the overall samples available (rs1360780: 0.308; rs755668: 0.067; rs3800373: 0.291).</p></fn></table-wrap-foot></table-wrap></floats-group></pmc><affiliations><list><country><li>Australie</li><li>France</li><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Rao, Shuquan" sort="Rao, Shuquan" uniqKey="Rao S" first="Shuquan" last="Rao">Shuquan Rao</name></noRegion><name sortKey="Li, Tao" sort="Li, Tao" uniqKey="Li T" first="Tao" last="Li">Tao Li</name><name sortKey="Wang, Duan" sort="Wang, Duan" uniqKey="Wang D" first="Duan" last="Wang">Duan Wang</name><name sortKey="Xu, Qi" sort="Xu, Qi" uniqKey="Xu Q" first="Qi" last="Xu">Qi Xu</name><name sortKey="Xu, Yong" sort="Xu, Yong" uniqKey="Xu Y" first="Yong" last="Xu">Yong Xu</name><name sortKey="Yao, Yao" sort="Yao, Yao" uniqKey="Yao Y" first="Yao" last="Yao">Yao Yao</name><name sortKey="Zheng, Chuan" sort="Zheng, Chuan" uniqKey="Zheng C" first="Chuan" last="Zheng">Chuan Zheng</name></country><country name="Australie"><noRegion><name sortKey="Ryan, Joanne" sort="Ryan, Joanne" uniqKey="Ryan J" first="Joanne" last="Ryan">Joanne Ryan</name></noRegion></country><country name="France"><noRegion><name sortKey="Ryan, Joanne" sort="Ryan, Joanne" uniqKey="Ryan J" first="Joanne" last="Ryan">Joanne Ryan</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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