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Staphylococcus aureus endocarditis : A consequence of medical progress

Identifieur interne : 004909 ( PascalFrancis/Corpus ); précédent : 004908; suivant : 004910

Staphylococcus aureus endocarditis : A consequence of medical progress

Auteurs : Vance G. Jr Fowler ; Jose M. Miro ; Bruno Hoen ; Christopher H. Cabell ; Elias Abrutyn ; Ethan Rubinstein ; Llb G. Ralph Corey ; Denis Spelman ; Suzanne F. Bradley ; Bruno Barsic ; Paul A. Pappas ; Kevin J. Anstrom ; Dannah Wray ; Claudio Q. Fortes ; Ignasi Anguera ; Eugene Athan ; Philip Jones ; Jan T. M. Van Der Meer ; Tom S. J. Elliott ; Donald P. Levine ; Arnold S. Bayer

Source :

RBID : Pascal:05-0289831

Descripteurs français

English descriptors

Abstract

Context The global significance of infective endocarditis (IE) caused by Staphylococcus aureus is unknown. Objectives To document the international emergence of health care-associated S aureus IE and methicillin-resistant S aureus (MRSA) IE and to evaluate regional variation in patients with S aureus IE. Design, Setting, and Participants Prospective observational cohort study set in 39 medical centers in 16 countries. Participants were a population of 1779 patients with definite IE as defined by Duke criteria who were enrolled in the International Collaboration on Endocarditis-Prospective Cohort Study from June 2000 to December 2003. Main Outcome Measure In-hospital mortality. Results S aureus was the most common pathogen among the 1779 cases of definite IE in the International Collaboration on Endocarditis Prospective-Cohort Study (558 patients, 31.4%). Health care-associated infection was the most common form of S aureus IE (218 patients, 39.1%), accounting for 25.9% (Australia/New Zealand) to 54.2% (Brazil) of cases. Most patients with health care-associated S aureus I E (131 patients, 60.1 %) acquired the infection outside of the hospital. MRSA IE was more common in the United States (37.2%) and Brazil (37.5%) than in Europe/Middle East (23.7%) and Australia/ New Zealand (15.5%, P<.001). Persistent bacteremia was independently associated with MRSA IE (odds ratio, 6.2; 95% confidence interval, 2.9-13.2). Patients in the United States were most likely to be hemodialysis dependent, to have diabetes, to have a presumed intravascular device source, to receive vancomycin, to be infected with MRSA, and to have persistent bacteremia (P<.001 for all comparisons). Conclusions S aureus is the leading cause of IE in many regions of the world. Characteristics of patients with S aureus IE vary significantly by region. Further studies are required to determine the causes of regional variation.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

pA  
A01 01  1    @0 0098-7484
A03   1    @0 JAMA j. Am. Med. Assoc.
A05       @2 293
A06       @2 24
A08 01  1  ENG  @1 Staphylococcus aureus endocarditis : A consequence of medical progress
A11 01  1    @1 FOWLER (Vance G. JR)
A11 02  1    @1 MIRO (Jose M.)
A11 03  1    @1 HOEN (Bruno)
A11 04  1    @1 CABELL (Christopher H.)
A11 05  1    @1 ABRUTYN (Elias)
A11 06  1    @1 RUBINSTEIN (Ethan)
A11 07  1    @1 RALPH COREY (Llb G.)
A11 08  1    @1 SPELMAN (Denis)
A11 09  1    @1 BRADLEY (Suzanne F.)
A11 10  1    @1 BARSIC (Bruno)
A11 11  1    @1 PAPPAS (Paul A.)
A11 12  1    @1 ANSTROM (Kevin J.)
A11 13  1    @1 WRAY (Dannah)
A11 14  1    @1 FORTES (Claudio Q.)
A11 15  1    @1 ANGUERA (Ignasi)
A11 16  1    @1 ATHAN (Eugene)
A11 17  1    @1 JONES (Philip)
A11 18  1    @1 VAN DER MEER (Jan T. M.)
A11 19  1    @1 ELLIOTT (Tom S. J.)
A11 20  1    @1 LEVINE (Donald P.)
A11 21  1    @1 BAYER (Arnold S.)
A14 01      @1 Duke University Medical Center @2 Durham, NC @3 USA @Z 1 aut. @Z 4 aut. @Z 7 aut. @Z 11 aut. @Z 12 aut.
A14 02      @1 Hospital Clinic-IDIBAPS, University of Barcelona @3 ESP @Z 2 aut.
A14 03      @1 Hôpital Saint-Jacques @2 Besançon @3 FRA @Z 3 aut.
A14 04      @1 Drexel University College of Medicine @2 Philadelphia, Pa @3 USA @Z 5 aut.
A14 05      @1 Tel Aviv University, School of Medicine @2 Tel Aviv @3 ISR @Z 6 aut.
A14 06      @1 Alfred Hospital @2 Melbourne @3 AUS @Z 8 aut.
A14 07      @1 University of Michigan @2 Ann Arbor @3 USA @Z 9 aut.
A14 08      @1 University Hospital for Infectious Diseases @2 Zagreb @3 HRV @Z 10 aut.
A14 09      @1 Medical University of South Carolina @2 Charleston @3 USA @Z 13 aut.
A14 10      @1 Hospital Universitario Clementino Fraga Filho @2 Rio de Janeiro @3 BRA @Z 14 aut.
A14 11      @1 Hospital de Sabadell @2 Sabadell @3 ESP @Z 15 aut.
A14 12      @1 Geelong Hospital @2 Geelong @3 AUS @Z 16 aut.
A14 13      @1 Prince of Wales Hospital @2 Sydney @3 AUS @Z 17 aut.
A14 14      @1 Academic Medical Center, University of Amsterdam @3 NLD @Z 18 aut.
A14 15      @1 Queen Elizabeth Hospital @2 Birmingham, England @3 GBR @Z 19 aut.
A14 16      @1 Wayne State University @2 Detroit, Mich @3 USA @Z 20 aut.
A14 17      @1 Harbor-UCLA Medical Center and the LA Biomedical Research Institute @2 Los Angeles @3 USA @Z 21 aut.
A17 01  1    @1 ICE Investigators @3 INC
A20       @1 3012-3021
A21       @1 2005
A23 01      @0 ENG
A43 01      @1 INIST @2 5051 @5 354000138115190020
A44       @0 0000 @1 © 2005 INIST-CNRS. All rights reserved.
A45       @0 37 ref.
A47 01  1    @0 05-0289831
A60       @1 P
A61       @0 A
A64 01  1    @0 JAMA, the journal of the American Medical Association
A66 01      @0 USA
C01 01    ENG  @0 Context The global significance of infective endocarditis (IE) caused by Staphylococcus aureus is unknown. Objectives To document the international emergence of health care-associated S aureus IE and methicillin-resistant S aureus (MRSA) IE and to evaluate regional variation in patients with S aureus IE. Design, Setting, and Participants Prospective observational cohort study set in 39 medical centers in 16 countries. Participants were a population of 1779 patients with definite IE as defined by Duke criteria who were enrolled in the International Collaboration on Endocarditis-Prospective Cohort Study from June 2000 to December 2003. Main Outcome Measure In-hospital mortality. Results S aureus was the most common pathogen among the 1779 cases of definite IE in the International Collaboration on Endocarditis Prospective-Cohort Study (558 patients, 31.4%). Health care-associated infection was the most common form of S aureus IE (218 patients, 39.1%), accounting for 25.9% (Australia/New Zealand) to 54.2% (Brazil) of cases. Most patients with health care-associated S aureus I E (131 patients, 60.1 %) acquired the infection outside of the hospital. MRSA IE was more common in the United States (37.2%) and Brazil (37.5%) than in Europe/Middle East (23.7%) and Australia/ New Zealand (15.5%, P<.001). Persistent bacteremia was independently associated with MRSA IE (odds ratio, 6.2; 95% confidence interval, 2.9-13.2). Patients in the United States were most likely to be hemodialysis dependent, to have diabetes, to have a presumed intravascular device source, to receive vancomycin, to be infected with MRSA, and to have persistent bacteremia (P<.001 for all comparisons). Conclusions S aureus is the leading cause of IE in many regions of the world. Characteristics of patients with S aureus IE vary significantly by region. Further studies are required to determine the causes of regional variation.
C02 01  X    @0 002B01
C02 02  X    @0 002B12A04
C03 01  X  FRE  @0 Endocardite @5 01
C03 01  X  ENG  @0 Endocarditis @5 01
C03 01  X  SPA  @0 Endocarditis @5 01
C03 02  X  FRE  @0 Staphylococcus aureus @2 NS @5 02
C03 02  X  ENG  @0 Staphylococcus aureus @2 NS @5 02
C03 02  X  SPA  @0 Staphylococcus aureus @2 NS @5 02
C03 03  X  FRE  @0 Staphylococcie @5 03
C03 03  X  ENG  @0 Staphylococcal infection @5 03
C03 03  X  SPA  @0 Estafilococia @5 03
C03 04  X  FRE  @0 Médecine @5 05
C03 04  X  ENG  @0 Medicine @5 05
C03 04  X  SPA  @0 Medicina @5 05
C07 01  X  FRE  @0 Micrococcaceae @2 NS
C07 01  X  ENG  @0 Micrococcaceae @2 NS
C07 01  X  SPA  @0 Micrococcaceae @2 NS
C07 02  X  FRE  @0 Micrococcales @2 NS
C07 02  X  ENG  @0 Micrococcales @2 NS
C07 02  X  SPA  @0 Micrococcales @2 NS
C07 03  X  FRE  @0 Bactérie
C07 03  X  ENG  @0 Bacteria
C07 03  X  SPA  @0 Bacteria
C07 04  X  FRE  @0 Bactériose
C07 04  X  ENG  @0 Bacteriosis
C07 04  X  SPA  @0 Bacteriosis
C07 05  X  FRE  @0 Infection
C07 05  X  ENG  @0 Infection
C07 05  X  SPA  @0 Infección
C07 06  X  FRE  @0 Appareil circulatoire pathologie @5 37
C07 06  X  ENG  @0 Cardiovascular disease @5 37
C07 06  X  SPA  @0 Aparato circulatorio patología @5 37
C07 07  X  FRE  @0 Cardiopathie @5 38
C07 07  X  ENG  @0 Heart disease @5 38
C07 07  X  SPA  @0 Cardiopatía @5 38
C07 08  X  FRE  @0 Endocarde pathologie @5 39
C07 08  X  ENG  @0 Endocardial disease @5 39
C07 08  X  SPA  @0 Endocardio patología @5 39
N21       @1 199
N44 01      @1 OTO
N82       @1 OTO

Format Inist (serveur)

NO : PASCAL 05-0289831 INIST
ET : Staphylococcus aureus endocarditis : A consequence of medical progress
AU : FOWLER (Vance G. JR); MIRO (Jose M.); HOEN (Bruno); CABELL (Christopher H.); ABRUTYN (Elias); RUBINSTEIN (Ethan); RALPH COREY (Llb G.); SPELMAN (Denis); BRADLEY (Suzanne F.); BARSIC (Bruno); PAPPAS (Paul A.); ANSTROM (Kevin J.); WRAY (Dannah); FORTES (Claudio Q.); ANGUERA (Ignasi); ATHAN (Eugene); JONES (Philip); VAN DER MEER (Jan T. M.); ELLIOTT (Tom S. J.); LEVINE (Donald P.); BAYER (Arnold S.)
AF : Duke University Medical Center/Durham, NC/Etats-Unis (1 aut., 4 aut., 7 aut., 11 aut., 12 aut.); Hospital Clinic-IDIBAPS, University of Barcelona/Espagne (2 aut.); Hôpital Saint-Jacques/Besançon/France (3 aut.); Drexel University College of Medicine/Philadelphia, Pa/Etats-Unis (5 aut.); Tel Aviv University, School of Medicine/Tel Aviv/Israël (6 aut.); Alfred Hospital/Melbourne/Australie (8 aut.); University of Michigan/Ann Arbor/Etats-Unis (9 aut.); University Hospital for Infectious Diseases/Zagreb/Croatie (10 aut.); Medical University of South Carolina/Charleston/Etats-Unis (13 aut.); Hospital Universitario Clementino Fraga Filho/Rio de Janeiro/Brésil (14 aut.); Hospital de Sabadell/Sabadell/Espagne (15 aut.); Geelong Hospital/Geelong/Australie (16 aut.); Prince of Wales Hospital/Sydney/Australie (17 aut.); Academic Medical Center, University of Amsterdam/Pays-Bas (18 aut.); Queen Elizabeth Hospital/Birmingham, England/Royaume-Uni (19 aut.); Wayne State University/Detroit, Mich/Etats-Unis (20 aut.); Harbor-UCLA Medical Center and the LA Biomedical Research Institute/Los Angeles/Etats-Unis (21 aut.)
DT : Publication en série; Niveau analytique
SO : JAMA, the journal of the American Medical Association; ISSN 0098-7484; Etats-Unis; Da. 2005; Vol. 293; No. 24; Pp. 3012-3021; Bibl. 37 ref.
LA : Anglais
EA : Context The global significance of infective endocarditis (IE) caused by Staphylococcus aureus is unknown. Objectives To document the international emergence of health care-associated S aureus IE and methicillin-resistant S aureus (MRSA) IE and to evaluate regional variation in patients with S aureus IE. Design, Setting, and Participants Prospective observational cohort study set in 39 medical centers in 16 countries. Participants were a population of 1779 patients with definite IE as defined by Duke criteria who were enrolled in the International Collaboration on Endocarditis-Prospective Cohort Study from June 2000 to December 2003. Main Outcome Measure In-hospital mortality. Results S aureus was the most common pathogen among the 1779 cases of definite IE in the International Collaboration on Endocarditis Prospective-Cohort Study (558 patients, 31.4%). Health care-associated infection was the most common form of S aureus IE (218 patients, 39.1%), accounting for 25.9% (Australia/New Zealand) to 54.2% (Brazil) of cases. Most patients with health care-associated S aureus I E (131 patients, 60.1 %) acquired the infection outside of the hospital. MRSA IE was more common in the United States (37.2%) and Brazil (37.5%) than in Europe/Middle East (23.7%) and Australia/ New Zealand (15.5%, P<.001). Persistent bacteremia was independently associated with MRSA IE (odds ratio, 6.2; 95% confidence interval, 2.9-13.2). Patients in the United States were most likely to be hemodialysis dependent, to have diabetes, to have a presumed intravascular device source, to receive vancomycin, to be infected with MRSA, and to have persistent bacteremia (P<.001 for all comparisons). Conclusions S aureus is the leading cause of IE in many regions of the world. Characteristics of patients with S aureus IE vary significantly by region. Further studies are required to determine the causes of regional variation.
CC : 002B01; 002B12A04
FD : Endocardite; Staphylococcus aureus; Staphylococcie; Médecine
FG : Micrococcaceae; Micrococcales; Bactérie; Bactériose; Infection; Appareil circulatoire pathologie; Cardiopathie; Endocarde pathologie
ED : Endocarditis; Staphylococcus aureus; Staphylococcal infection; Medicine
EG : Micrococcaceae; Micrococcales; Bacteria; Bacteriosis; Infection; Cardiovascular disease; Heart disease; Endocardial disease
SD : Endocarditis; Staphylococcus aureus; Estafilococia; Medicina
LO : INIST-5051.354000138115190020
ID : 05-0289831

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Pascal:05-0289831

Le document en format XML

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<title xml:lang="en" level="a">Staphylococcus aureus endocarditis : A consequence of medical progress</title>
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<name sortKey="Hoen, Bruno" sort="Hoen, Bruno" uniqKey="Hoen B" first="Bruno" last="Hoen">Bruno Hoen</name>
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<s1>Hôpital Saint-Jacques</s1>
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<name sortKey="Cabell, Christopher H" sort="Cabell, Christopher H" uniqKey="Cabell C" first="Christopher H." last="Cabell">Christopher H. Cabell</name>
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</affiliation>
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<author>
<name sortKey="Rubinstein, Ethan" sort="Rubinstein, Ethan" uniqKey="Rubinstein E" first="Ethan" last="Rubinstein">Ethan Rubinstein</name>
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<inist:fA14 i1="05">
<s1>Tel Aviv University, School of Medicine</s1>
<s2>Tel Aviv</s2>
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<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author>
<name sortKey="Ralph Corey, Llb G" sort="Ralph Corey, Llb G" uniqKey="Ralph Corey L" first="Llb G." last="Ralph Corey">Llb G. Ralph Corey</name>
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<inist:fA14 i1="01">
<s1>Duke University Medical Center</s1>
<s2>Durham, NC</s2>
<s3>USA</s3>
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<name sortKey="Spelman, Denis" sort="Spelman, Denis" uniqKey="Spelman D" first="Denis" last="Spelman">Denis Spelman</name>
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<inist:fA14 i1="06">
<s1>Alfred Hospital</s1>
<s2>Melbourne</s2>
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<sZ>8 aut.</sZ>
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</author>
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<name sortKey="Bradley, Suzanne F" sort="Bradley, Suzanne F" uniqKey="Bradley S" first="Suzanne F." last="Bradley">Suzanne F. Bradley</name>
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<inist:fA14 i1="07">
<s1>University of Michigan</s1>
<s2>Ann Arbor</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author>
<name sortKey="Barsic, Bruno" sort="Barsic, Bruno" uniqKey="Barsic B" first="Bruno" last="Barsic">Bruno Barsic</name>
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<inist:fA14 i1="08">
<s1>University Hospital for Infectious Diseases</s1>
<s2>Zagreb</s2>
<s3>HRV</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author>
<name sortKey="Pappas, Paul A" sort="Pappas, Paul A" uniqKey="Pappas P" first="Paul A." last="Pappas">Paul A. Pappas</name>
<affiliation>
<inist:fA14 i1="01">
<s1>Duke University Medical Center</s1>
<s2>Durham, NC</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author>
<name sortKey="Anstrom, Kevin J" sort="Anstrom, Kevin J" uniqKey="Anstrom K" first="Kevin J." last="Anstrom">Kevin J. Anstrom</name>
<affiliation>
<inist:fA14 i1="01">
<s1>Duke University Medical Center</s1>
<s2>Durham, NC</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
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</affiliation>
</author>
<author>
<name sortKey="Wray, Dannah" sort="Wray, Dannah" uniqKey="Wray D" first="Dannah" last="Wray">Dannah Wray</name>
<affiliation>
<inist:fA14 i1="09">
<s1>Medical University of South Carolina</s1>
<s2>Charleston</s2>
<s3>USA</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author>
<name sortKey="Fortes, Claudio Q" sort="Fortes, Claudio Q" uniqKey="Fortes C" first="Claudio Q." last="Fortes">Claudio Q. Fortes</name>
<affiliation>
<inist:fA14 i1="10">
<s1>Hospital Universitario Clementino Fraga Filho</s1>
<s2>Rio de Janeiro</s2>
<s3>BRA</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author>
<name sortKey="Anguera, Ignasi" sort="Anguera, Ignasi" uniqKey="Anguera I" first="Ignasi" last="Anguera">Ignasi Anguera</name>
<affiliation>
<inist:fA14 i1="11">
<s1>Hospital de Sabadell</s1>
<s2>Sabadell</s2>
<s3>ESP</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author>
<name sortKey="Athan, Eugene" sort="Athan, Eugene" uniqKey="Athan E" first="Eugene" last="Athan">Eugene Athan</name>
<affiliation>
<inist:fA14 i1="12">
<s1>Geelong Hospital</s1>
<s2>Geelong</s2>
<s3>AUS</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author>
<name sortKey="Jones, Philip" sort="Jones, Philip" uniqKey="Jones P" first="Philip" last="Jones">Philip Jones</name>
<affiliation>
<inist:fA14 i1="13">
<s1>Prince of Wales Hospital</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author>
<name sortKey="Van Der Meer, Jan T M" sort="Van Der Meer, Jan T M" uniqKey="Van Der Meer J" first="Jan T. M." last="Van Der Meer">Jan T. M. Van Der Meer</name>
<affiliation>
<inist:fA14 i1="14">
<s1>Academic Medical Center, University of Amsterdam</s1>
<s3>NLD</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author>
<name sortKey="Elliott, Tom S J" sort="Elliott, Tom S J" uniqKey="Elliott T" first="Tom S. J." last="Elliott">Tom S. J. Elliott</name>
<affiliation>
<inist:fA14 i1="15">
<s1>Queen Elizabeth Hospital</s1>
<s2>Birmingham, England</s2>
<s3>GBR</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author>
<name sortKey="Levine, Donald P" sort="Levine, Donald P" uniqKey="Levine D" first="Donald P." last="Levine">Donald P. Levine</name>
<affiliation>
<inist:fA14 i1="16">
<s1>Wayne State University</s1>
<s2>Detroit, Mich</s2>
<s3>USA</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author>
<name sortKey="Bayer, Arnold S" sort="Bayer, Arnold S" uniqKey="Bayer A" first="Arnold S." last="Bayer">Arnold S. Bayer</name>
<affiliation>
<inist:fA14 i1="17">
<s1>Harbor-UCLA Medical Center and the LA Biomedical Research Institute</s1>
<s2>Los Angeles</s2>
<s3>USA</s3>
<sZ>21 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</analytic>
<series>
<title level="j" type="main">JAMA, the journal of the American Medical Association</title>
<title level="j" type="abbreviated">JAMA j. Am. Med. Assoc.</title>
<idno type="ISSN">0098-7484</idno>
<imprint>
<date when="2005">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt>
<title level="j" type="main">JAMA, the journal of the American Medical Association</title>
<title level="j" type="abbreviated">JAMA j. Am. Med. Assoc.</title>
<idno type="ISSN">0098-7484</idno>
</seriesStmt>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Endocarditis</term>
<term>Medicine</term>
<term>Staphylococcal infection</term>
<term>Staphylococcus aureus</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr">
<term>Endocardite</term>
<term>Staphylococcus aureus</term>
<term>Staphylococcie</term>
<term>Médecine</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">Context The global significance of infective endocarditis (IE) caused by Staphylococcus aureus is unknown. Objectives To document the international emergence of health care-associated S aureus IE and methicillin-resistant S aureus (MRSA) IE and to evaluate regional variation in patients with S aureus IE. Design, Setting, and Participants Prospective observational cohort study set in 39 medical centers in 16 countries. Participants were a population of 1779 patients with definite IE as defined by Duke criteria who were enrolled in the International Collaboration on Endocarditis-Prospective Cohort Study from June 2000 to December 2003. Main Outcome Measure In-hospital mortality. Results S aureus was the most common pathogen among the 1779 cases of definite IE in the International Collaboration on Endocarditis Prospective-Cohort Study (558 patients, 31.4%). Health care-associated infection was the most common form of S aureus IE (218 patients, 39.1%), accounting for 25.9% (Australia/New Zealand) to 54.2% (Brazil) of cases. Most patients with health care-associated S aureus I E (131 patients, 60.1 %) acquired the infection outside of the hospital. MRSA IE was more common in the United States (37.2%) and Brazil (37.5%) than in Europe/Middle East (23.7%) and Australia/ New Zealand (15.5%, P<.001). Persistent bacteremia was independently associated with MRSA IE (odds ratio, 6.2; 95% confidence interval, 2.9-13.2). Patients in the United States were most likely to be hemodialysis dependent, to have diabetes, to have a presumed intravascular device source, to receive vancomycin, to be infected with MRSA, and to have persistent bacteremia (P<.001 for all comparisons). Conclusions S aureus is the leading cause of IE in many regions of the world. Characteristics of patients with S aureus IE vary significantly by region. Further studies are required to determine the causes of regional variation.</div>
</front>
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<fA08 i1="01" i2="1" l="ENG">
<s1>Staphylococcus aureus endocarditis : A consequence of medical progress</s1>
</fA08>
<fA11 i1="01" i2="1">
<s1>FOWLER (Vance G. JR)</s1>
</fA11>
<fA11 i1="02" i2="1">
<s1>MIRO (Jose M.)</s1>
</fA11>
<fA11 i1="03" i2="1">
<s1>HOEN (Bruno)</s1>
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<fA11 i1="04" i2="1">
<s1>CABELL (Christopher H.)</s1>
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<s1>ABRUTYN (Elias)</s1>
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<s1>RUBINSTEIN (Ethan)</s1>
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<s1>RALPH COREY (Llb G.)</s1>
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<s1>BRADLEY (Suzanne F.)</s1>
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<s1>BARSIC (Bruno)</s1>
</fA11>
<fA11 i1="11" i2="1">
<s1>PAPPAS (Paul A.)</s1>
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<fA11 i1="12" i2="1">
<s1>ANSTROM (Kevin J.)</s1>
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<s1>WRAY (Dannah)</s1>
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<s1>FORTES (Claudio Q.)</s1>
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<s1>ANGUERA (Ignasi)</s1>
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<fA11 i1="16" i2="1">
<s1>ATHAN (Eugene)</s1>
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<s1>JONES (Philip)</s1>
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<fA11 i1="18" i2="1">
<s1>VAN DER MEER (Jan T. M.)</s1>
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<s1>ELLIOTT (Tom S. J.)</s1>
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<fA11 i1="20" i2="1">
<s1>LEVINE (Donald P.)</s1>
</fA11>
<fA11 i1="21" i2="1">
<s1>BAYER (Arnold S.)</s1>
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<s1>Duke University Medical Center</s1>
<s2>Durham, NC</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="02">
<s1>Hospital Clinic-IDIBAPS, University of Barcelona</s1>
<s3>ESP</s3>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="03">
<s1>Hôpital Saint-Jacques</s1>
<s2>Besançon</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="04">
<s1>Drexel University College of Medicine</s1>
<s2>Philadelphia, Pa</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="05">
<s1>Tel Aviv University, School of Medicine</s1>
<s2>Tel Aviv</s2>
<s3>ISR</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="06">
<s1>Alfred Hospital</s1>
<s2>Melbourne</s2>
<s3>AUS</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="07">
<s1>University of Michigan</s1>
<s2>Ann Arbor</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="08">
<s1>University Hospital for Infectious Diseases</s1>
<s2>Zagreb</s2>
<s3>HRV</s3>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="09">
<s1>Medical University of South Carolina</s1>
<s2>Charleston</s2>
<s3>USA</s3>
<sZ>13 aut.</sZ>
</fA14>
<fA14 i1="10">
<s1>Hospital Universitario Clementino Fraga Filho</s1>
<s2>Rio de Janeiro</s2>
<s3>BRA</s3>
<sZ>14 aut.</sZ>
</fA14>
<fA14 i1="11">
<s1>Hospital de Sabadell</s1>
<s2>Sabadell</s2>
<s3>ESP</s3>
<sZ>15 aut.</sZ>
</fA14>
<fA14 i1="12">
<s1>Geelong Hospital</s1>
<s2>Geelong</s2>
<s3>AUS</s3>
<sZ>16 aut.</sZ>
</fA14>
<fA14 i1="13">
<s1>Prince of Wales Hospital</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>17 aut.</sZ>
</fA14>
<fA14 i1="14">
<s1>Academic Medical Center, University of Amsterdam</s1>
<s3>NLD</s3>
<sZ>18 aut.</sZ>
</fA14>
<fA14 i1="15">
<s1>Queen Elizabeth Hospital</s1>
<s2>Birmingham, England</s2>
<s3>GBR</s3>
<sZ>19 aut.</sZ>
</fA14>
<fA14 i1="16">
<s1>Wayne State University</s1>
<s2>Detroit, Mich</s2>
<s3>USA</s3>
<sZ>20 aut.</sZ>
</fA14>
<fA14 i1="17">
<s1>Harbor-UCLA Medical Center and the LA Biomedical Research Institute</s1>
<s2>Los Angeles</s2>
<s3>USA</s3>
<sZ>21 aut.</sZ>
</fA14>
<fA17 i1="01" i2="1">
<s1>ICE Investigators</s1>
<s3>INC</s3>
</fA17>
<fA20>
<s1>3012-3021</s1>
</fA20>
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<s1>2005</s1>
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<s1>INIST</s1>
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<s5>354000138115190020</s5>
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<s1>© 2005 INIST-CNRS. All rights reserved.</s1>
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<s0>USA</s0>
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<s0>Context The global significance of infective endocarditis (IE) caused by Staphylococcus aureus is unknown. Objectives To document the international emergence of health care-associated S aureus IE and methicillin-resistant S aureus (MRSA) IE and to evaluate regional variation in patients with S aureus IE. Design, Setting, and Participants Prospective observational cohort study set in 39 medical centers in 16 countries. Participants were a population of 1779 patients with definite IE as defined by Duke criteria who were enrolled in the International Collaboration on Endocarditis-Prospective Cohort Study from June 2000 to December 2003. Main Outcome Measure In-hospital mortality. Results S aureus was the most common pathogen among the 1779 cases of definite IE in the International Collaboration on Endocarditis Prospective-Cohort Study (558 patients, 31.4%). Health care-associated infection was the most common form of S aureus IE (218 patients, 39.1%), accounting for 25.9% (Australia/New Zealand) to 54.2% (Brazil) of cases. Most patients with health care-associated S aureus I E (131 patients, 60.1 %) acquired the infection outside of the hospital. MRSA IE was more common in the United States (37.2%) and Brazil (37.5%) than in Europe/Middle East (23.7%) and Australia/ New Zealand (15.5%, P<.001). Persistent bacteremia was independently associated with MRSA IE (odds ratio, 6.2; 95% confidence interval, 2.9-13.2). Patients in the United States were most likely to be hemodialysis dependent, to have diabetes, to have a presumed intravascular device source, to receive vancomycin, to be infected with MRSA, and to have persistent bacteremia (P<.001 for all comparisons). Conclusions S aureus is the leading cause of IE in many regions of the world. Characteristics of patients with S aureus IE vary significantly by region. Further studies are required to determine the causes of regional variation.</s0>
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<s0>Endocardite</s0>
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<s0>Infection</s0>
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<s5>37</s5>
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<s0>Cardiovascular disease</s0>
<s5>37</s5>
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<s0>Aparato circulatorio patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE">
<s0>Cardiopathie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG">
<s0>Heart disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA">
<s0>Cardiopatía</s0>
<s5>38</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE">
<s0>Endocarde pathologie</s0>
<s5>39</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG">
<s0>Endocardial disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA">
<s0>Endocardio patología</s0>
<s5>39</s5>
</fC07>
<fN21>
<s1>199</s1>
</fN21>
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<NO>PASCAL 05-0289831 INIST</NO>
<ET>Staphylococcus aureus endocarditis : A consequence of medical progress</ET>
<AU>FOWLER (Vance G. JR); MIRO (Jose M.); HOEN (Bruno); CABELL (Christopher H.); ABRUTYN (Elias); RUBINSTEIN (Ethan); RALPH COREY (Llb G.); SPELMAN (Denis); BRADLEY (Suzanne F.); BARSIC (Bruno); PAPPAS (Paul A.); ANSTROM (Kevin J.); WRAY (Dannah); FORTES (Claudio Q.); ANGUERA (Ignasi); ATHAN (Eugene); JONES (Philip); VAN DER MEER (Jan T. M.); ELLIOTT (Tom S. J.); LEVINE (Donald P.); BAYER (Arnold S.)</AU>
<AF>Duke University Medical Center/Durham, NC/Etats-Unis (1 aut., 4 aut., 7 aut., 11 aut., 12 aut.); Hospital Clinic-IDIBAPS, University of Barcelona/Espagne (2 aut.); Hôpital Saint-Jacques/Besançon/France (3 aut.); Drexel University College of Medicine/Philadelphia, Pa/Etats-Unis (5 aut.); Tel Aviv University, School of Medicine/Tel Aviv/Israël (6 aut.); Alfred Hospital/Melbourne/Australie (8 aut.); University of Michigan/Ann Arbor/Etats-Unis (9 aut.); University Hospital for Infectious Diseases/Zagreb/Croatie (10 aut.); Medical University of South Carolina/Charleston/Etats-Unis (13 aut.); Hospital Universitario Clementino Fraga Filho/Rio de Janeiro/Brésil (14 aut.); Hospital de Sabadell/Sabadell/Espagne (15 aut.); Geelong Hospital/Geelong/Australie (16 aut.); Prince of Wales Hospital/Sydney/Australie (17 aut.); Academic Medical Center, University of Amsterdam/Pays-Bas (18 aut.); Queen Elizabeth Hospital/Birmingham, England/Royaume-Uni (19 aut.); Wayne State University/Detroit, Mich/Etats-Unis (20 aut.); Harbor-UCLA Medical Center and the LA Biomedical Research Institute/Los Angeles/Etats-Unis (21 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>JAMA, the journal of the American Medical Association; ISSN 0098-7484; Etats-Unis; Da. 2005; Vol. 293; No. 24; Pp. 3012-3021; Bibl. 37 ref.</SO>
<LA>Anglais</LA>
<EA>Context The global significance of infective endocarditis (IE) caused by Staphylococcus aureus is unknown. Objectives To document the international emergence of health care-associated S aureus IE and methicillin-resistant S aureus (MRSA) IE and to evaluate regional variation in patients with S aureus IE. Design, Setting, and Participants Prospective observational cohort study set in 39 medical centers in 16 countries. Participants were a population of 1779 patients with definite IE as defined by Duke criteria who were enrolled in the International Collaboration on Endocarditis-Prospective Cohort Study from June 2000 to December 2003. Main Outcome Measure In-hospital mortality. Results S aureus was the most common pathogen among the 1779 cases of definite IE in the International Collaboration on Endocarditis Prospective-Cohort Study (558 patients, 31.4%). Health care-associated infection was the most common form of S aureus IE (218 patients, 39.1%), accounting for 25.9% (Australia/New Zealand) to 54.2% (Brazil) of cases. Most patients with health care-associated S aureus I E (131 patients, 60.1 %) acquired the infection outside of the hospital. MRSA IE was more common in the United States (37.2%) and Brazil (37.5%) than in Europe/Middle East (23.7%) and Australia/ New Zealand (15.5%, P<.001). Persistent bacteremia was independently associated with MRSA IE (odds ratio, 6.2; 95% confidence interval, 2.9-13.2). Patients in the United States were most likely to be hemodialysis dependent, to have diabetes, to have a presumed intravascular device source, to receive vancomycin, to be infected with MRSA, and to have persistent bacteremia (P<.001 for all comparisons). Conclusions S aureus is the leading cause of IE in many regions of the world. Characteristics of patients with S aureus IE vary significantly by region. Further studies are required to determine the causes of regional variation.</EA>
<CC>002B01; 002B12A04</CC>
<FD>Endocardite; Staphylococcus aureus; Staphylococcie; Médecine</FD>
<FG>Micrococcaceae; Micrococcales; Bactérie; Bactériose; Infection; Appareil circulatoire pathologie; Cardiopathie; Endocarde pathologie</FG>
<ED>Endocarditis; Staphylococcus aureus; Staphylococcal infection; Medicine</ED>
<EG>Micrococcaceae; Micrococcales; Bacteria; Bacteriosis; Infection; Cardiovascular disease; Heart disease; Endocardial disease</EG>
<SD>Endocarditis; Staphylococcus aureus; Estafilococia; Medicina</SD>
<LO>INIST-5051.354000138115190020</LO>
<ID>05-0289831</ID>
</server>
</inist>
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