Clinical Presentation, Etiology, and Outcome of Infective Endocarditis in the 21st Century : The International Collaboration on Endocarditis-Prospective Cohort Study
Identifieur interne : 002F57 ( PascalFrancis/Corpus ); précédent : 002F56; suivant : 002F58Clinical Presentation, Etiology, and Outcome of Infective Endocarditis in the 21st Century : The International Collaboration on Endocarditis-Prospective Cohort Study
Auteurs : David R. Murdoch ; G. Ralph Corey ; Bruno Hoen ; José M. Miro ; Vance G. Jr Fowler ; Arnold S. Bayer ; Adolf W. Karchmer ; Lars Olaison ; Paul A. Pappas ; Philippe Moreillon ; Stephen T. Chambers ; Vivian H. Chu ; Vicenc Falco ; David J. Holland ; Philip Jones ; John L. Klein ; Nigel J. Raymond ; Kerry M. Read ; Marie Francoise Tripodi ; Riccardo Utili ; Andrew Wang ; Christopher W. Woods ; Christopher H. CabellSource :
- Archives of internal medicine : (1960) [ 0003-9926 ] ; 2009.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Background: We sought to provide a contemporary picture of the presentation, etiology, and outcome of infective endocarditis (IE) in a large patient cohort from multiple locations worldwide. Methods: Prospective cohort study of 2781 adults with definite IE who were admitted to 58 hospitals in 25 countries from June 1, 2000, through September 1, 2005. Results: The median age of the cohort was 57.9 (interquartile range, 43.2-71.8) years, and 72.1% had native valve IE. Most patients (77.0%) presented early in the disease (<30 days) with few of the classic clinical hall-marks of IE. Recent health care exposure was found in one-quarter of patients. Staphylococcus aureus was the most common pathogen (31.2%). The mitral (41.1%) and aortic (37.6%) valves were infected most commonly. The following complications were common: stroke (16.9%), embolization other than stroke (22.6%), heart failure (32.3%), and intracardiac abscess (14.4%). Surgical therapy was common (48.2%), and in-hospital mortality remained high (17.7%). Prosthetic valve involvement (odds ratio, 1.47; 95% confidence interval, 1.13-1.90), increasing age (1.30; 1.17-1.46 per 10-year interval), pulmonary edema (1.79; 1.39-2.30), S aureus infection (1.54; 1.14-2.08), coagulase-negative staphylococcal infection (1.50; 1.07-2.10), mitral valve vegetation (1.34; 1.06-1.68), and paravalvular complications (2.25; 1.64-3.09) were associated with an increased risk of in-hospital death, whereas viridans streptococcal infection (0.52; 0.33-0.81) and surgery (0.61; 0.44-0.83) were associated with a decreased risk. Conclusions: In the early 21st century, IE is more often an acute disease, characterized by a high rate of S aureus infection. Mortality remains relatively high.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
pA |
|
---|
Format Inist (serveur)
NO : | PASCAL 09-0127281 INIST |
---|---|
ET : | Clinical Presentation, Etiology, and Outcome of Infective Endocarditis in the 21st Century : The International Collaboration on Endocarditis-Prospective Cohort Study |
AU : | MURDOCH (David R.); COREY (G. Ralph); HOEN (Bruno); MIRO (José M.); FOWLER (Vance G. JR); BAYER (Arnold S.); KARCHMER (Adolf W.); OLAISON (Lars); PAPPAS (Paul A.); MOREILLON (Philippe); CHAMBERS (Stephen T.); CHU (Vivian H.); FALCO (Vicenc); HOLLAND (David J.); JONES (Philip); KLEIN (John L.); RAYMOND (Nigel J.); READ (Kerry M.); FRANCOISE TRIPODI (Marie); UTILI (Riccardo); WANG (Andrew); WOODS (Christopher W.); CABELL (Christopher H.) |
AF : | Department of Pathology, University of Otago/Christchurch/Nouvelle-Zélande (1 aut., 11 aut.); Departments of Medicine, Duke University Medical Center/Durham, North Carolina/Etats-Unis (2 aut., 5 aut., 7 aut., 12 aut., 21 aut., 22 aut., 23 aut.); Duke Clinical Research Institute/Durham/Etats-Unis (2 aut., 5 aut., 9 aut., 23 aut.); Departments of Infectious Diseases, Hôpital Saint-Jacques/Besancon/France (3 aut.); Hospital Clinic-Institut d'lnvestigacions Biomèdiques August Pi I Sunyer, University of Barcelona/Barcelona/Espagne (4 aut.); Divisions of Infectious Diseases, University of California, Los Angeles, Harbor Medical Center/Torrance/Etats-Unis (6 aut.); Beth Israel-Deaconess Medical Center/Boston, Massachusetts/Etats-Unis (7 aut.); Sahlgrenska University Hospital/Goteborg/Suède (8 aut.); Centre Hospitalier Universitaire, University of Lausanne/Lausanne/Suisse (10 aut.); Hospital Universitari Vall D'Hebron/Barcelona/Espagne (13 aut.); Middlemore Hospital/Nouvelle-Zélande (14 aut.); University of New South Wales/Sydney/Australie (15 aut.); Department of Infection, St Thomas' Hospital/London/Royaume-Uni (16 aut.); Wellington Hospital/Wellington/Nouvelle-Zélande (17 aut.); North Shore Hospital/Auckland/Nouvelle-Zélande (18 aut.); Department of Cardiothoracic and Respiratory Services, Second University of Naples/Naples/Italie (19 aut., 20 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Archives of internal medicine : (1960); ISSN 0003-9926; Coden AIMDAP; Etats-Unis; Da. 2009; Vol. 169; No. 5; Pp. 463-473; Bibl. 41 ref. |
LA : | Anglais |
EA : | Background: We sought to provide a contemporary picture of the presentation, etiology, and outcome of infective endocarditis (IE) in a large patient cohort from multiple locations worldwide. Methods: Prospective cohort study of 2781 adults with definite IE who were admitted to 58 hospitals in 25 countries from June 1, 2000, through September 1, 2005. Results: The median age of the cohort was 57.9 (interquartile range, 43.2-71.8) years, and 72.1% had native valve IE. Most patients (77.0%) presented early in the disease (<30 days) with few of the classic clinical hall-marks of IE. Recent health care exposure was found in one-quarter of patients. Staphylococcus aureus was the most common pathogen (31.2%). The mitral (41.1%) and aortic (37.6%) valves were infected most commonly. The following complications were common: stroke (16.9%), embolization other than stroke (22.6%), heart failure (32.3%), and intracardiac abscess (14.4%). Surgical therapy was common (48.2%), and in-hospital mortality remained high (17.7%). Prosthetic valve involvement (odds ratio, 1.47; 95% confidence interval, 1.13-1.90), increasing age (1.30; 1.17-1.46 per 10-year interval), pulmonary edema (1.79; 1.39-2.30), S aureus infection (1.54; 1.14-2.08), coagulase-negative staphylococcal infection (1.50; 1.07-2.10), mitral valve vegetation (1.34; 1.06-1.68), and paravalvular complications (2.25; 1.64-3.09) were associated with an increased risk of in-hospital death, whereas viridans streptococcal infection (0.52; 0.33-0.81) and surgery (0.61; 0.44-0.83) were associated with a decreased risk. Conclusions: In the early 21st century, IE is more often an acute disease, characterized by a high rate of S aureus infection. Mortality remains relatively high. |
CC : | 002B30A03C; 002B01; 002B12A04 |
FD : | Endocardite; Symptomatologie; Etiologie; Evolution; Pronostic; Siècle 21eme; International; Monde; Prospective; Etude cohorte; Santé publique; Médecine; Homme |
FG : | Pathologie de l'appareil circulatoire; Cardiopathie; Pathologie de l'endocarde |
ED : | Endocarditis; Symptomatology; Etiology; Evolution; Prognosis; Century 21st; International; World; Prospective; Cohort study; Public health; Medicine; Human |
EG : | Cardiovascular disease; Heart disease; Endocardial disease |
SD : | Endocarditis; Sintomatología; Etiología; Evolución; Pronóstico; Siglo 21; Internacional; Mundo; Prospectiva; Estudio cohorte; Salud pública; Medicina; Hombre |
LO : | INIST-2040.354000187278500070 |
ID : | 09-0127281 |
Links to Exploration step
Pascal:09-0127281Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Clinical Presentation, Etiology, and Outcome of Infective Endocarditis in the 21st Century : The International Collaboration on Endocarditis-Prospective Cohort Study</title>
<author><name sortKey="Murdoch, David R" sort="Murdoch, David R" uniqKey="Murdoch D" first="David R." last="Murdoch">David R. Murdoch</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Pathology, University of Otago</s1>
<s2>Christchurch</s2>
<s3>NZL</s3>
<sZ>1 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Corey, G Ralph" sort="Corey, G Ralph" uniqKey="Corey G" first="G. Ralph" last="Corey">G. Ralph Corey</name>
<affiliation><inist:fA14 i1="02"><s1>Departments of Medicine, Duke University Medical Center</s1>
<s2>Durham, North Carolina</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="03"><s1>Duke Clinical Research Institute</s1>
<s2>Durham</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Hoen, Bruno" sort="Hoen, Bruno" uniqKey="Hoen B" first="Bruno" last="Hoen">Bruno Hoen</name>
<affiliation><inist:fA14 i1="04"><s1>Departments of Infectious Diseases, Hôpital Saint-Jacques</s1>
<s2>Besancon</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Miro, Jose M" sort="Miro, Jose M" uniqKey="Miro J" first="José M." last="Miro">José M. Miro</name>
<affiliation><inist:fA14 i1="05"><s1>Hospital Clinic-Institut d'lnvestigacions Biomèdiques August Pi I Sunyer, University of Barcelona</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Fowler, Vance G Jr" sort="Fowler, Vance G Jr" uniqKey="Fowler V" first="Vance G. Jr" last="Fowler">Vance G. Jr Fowler</name>
<affiliation><inist:fA14 i1="02"><s1>Departments of Medicine, Duke University Medical Center</s1>
<s2>Durham, North Carolina</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="03"><s1>Duke Clinical Research Institute</s1>
<s2>Durham</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Bayer, Arnold S" sort="Bayer, Arnold S" uniqKey="Bayer A" first="Arnold S." last="Bayer">Arnold S. Bayer</name>
<affiliation><inist:fA14 i1="06"><s1>Divisions of Infectious Diseases, University of California, Los Angeles, Harbor Medical Center</s1>
<s2>Torrance</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Karchmer, Adolf W" sort="Karchmer, Adolf W" uniqKey="Karchmer A" first="Adolf W." last="Karchmer">Adolf W. Karchmer</name>
<affiliation><inist:fA14 i1="02"><s1>Departments of Medicine, Duke University Medical Center</s1>
<s2>Durham, North Carolina</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="07"><s1>Beth Israel-Deaconess Medical Center</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Olaison, Lars" sort="Olaison, Lars" uniqKey="Olaison L" first="Lars" last="Olaison">Lars Olaison</name>
<affiliation><inist:fA14 i1="08"><s1>Sahlgrenska University Hospital</s1>
<s2>Goteborg</s2>
<s3>SWE</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Pappas, Paul A" sort="Pappas, Paul A" uniqKey="Pappas P" first="Paul A." last="Pappas">Paul A. Pappas</name>
<affiliation><inist:fA14 i1="03"><s1>Duke Clinical Research Institute</s1>
<s2>Durham</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Moreillon, Philippe" sort="Moreillon, Philippe" uniqKey="Moreillon P" first="Philippe" last="Moreillon">Philippe Moreillon</name>
<affiliation><inist:fA14 i1="09"><s1>Centre Hospitalier Universitaire, University of Lausanne</s1>
<s2>Lausanne</s2>
<s3>CHE</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Chambers, Stephen T" sort="Chambers, Stephen T" uniqKey="Chambers S" first="Stephen T." last="Chambers">Stephen T. Chambers</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Pathology, University of Otago</s1>
<s2>Christchurch</s2>
<s3>NZL</s3>
<sZ>1 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Chu, Vivian H" sort="Chu, Vivian H" uniqKey="Chu V" first="Vivian H." last="Chu">Vivian H. Chu</name>
<affiliation><inist:fA14 i1="02"><s1>Departments of Medicine, Duke University Medical Center</s1>
<s2>Durham, North Carolina</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Falco, Vicenc" sort="Falco, Vicenc" uniqKey="Falco V" first="Vicenc" last="Falco">Vicenc Falco</name>
<affiliation><inist:fA14 i1="10"><s1>Hospital Universitari Vall D'Hebron</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Holland, David J" sort="Holland, David J" uniqKey="Holland D" first="David J." last="Holland">David J. Holland</name>
<affiliation><inist:fA14 i1="11"><s1>Middlemore Hospital</s1>
<s3>NZL</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Jones, Philip" sort="Jones, Philip" uniqKey="Jones P" first="Philip" last="Jones">Philip Jones</name>
<affiliation><inist:fA14 i1="12"><s1>University of New South Wales</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Klein, John L" sort="Klein, John L" uniqKey="Klein J" first="John L." last="Klein">John L. Klein</name>
<affiliation><inist:fA14 i1="13"><s1>Department of Infection, St Thomas' Hospital</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Raymond, Nigel J" sort="Raymond, Nigel J" uniqKey="Raymond N" first="Nigel J." last="Raymond">Nigel J. Raymond</name>
<affiliation><inist:fA14 i1="14"><s1>Wellington Hospital</s1>
<s2>Wellington</s2>
<s3>NZL</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Read, Kerry M" sort="Read, Kerry M" uniqKey="Read K" first="Kerry M." last="Read">Kerry M. Read</name>
<affiliation><inist:fA14 i1="15"><s1>North Shore Hospital</s1>
<s2>Auckland</s2>
<s3>NZL</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Francoise Tripodi, Marie" sort="Francoise Tripodi, Marie" uniqKey="Francoise Tripodi M" first="Marie" last="Francoise Tripodi">Marie Francoise Tripodi</name>
<affiliation><inist:fA14 i1="16"><s1>Department of Cardiothoracic and Respiratory Services, Second University of Naples</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Utili, Riccardo" sort="Utili, Riccardo" uniqKey="Utili R" first="Riccardo" last="Utili">Riccardo Utili</name>
<affiliation><inist:fA14 i1="16"><s1>Department of Cardiothoracic and Respiratory Services, Second University of Naples</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Wang, Andrew" sort="Wang, Andrew" uniqKey="Wang A" first="Andrew" last="Wang">Andrew Wang</name>
<affiliation><inist:fA14 i1="02"><s1>Departments of Medicine, Duke University Medical Center</s1>
<s2>Durham, North Carolina</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Woods, Christopher W" sort="Woods, Christopher W" uniqKey="Woods C" first="Christopher W." last="Woods">Christopher W. Woods</name>
<affiliation><inist:fA14 i1="02"><s1>Departments of Medicine, Duke University Medical Center</s1>
<s2>Durham, North Carolina</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Cabell, Christopher H" sort="Cabell, Christopher H" uniqKey="Cabell C" first="Christopher H." last="Cabell">Christopher H. Cabell</name>
<affiliation><inist:fA14 i1="02"><s1>Departments of Medicine, Duke University Medical Center</s1>
<s2>Durham, North Carolina</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="03"><s1>Duke Clinical Research Institute</s1>
<s2>Durham</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">09-0127281</idno>
<date when="2009">2009</date>
<idno type="stanalyst">PASCAL 09-0127281 INIST</idno>
<idno type="RBID">Pascal:09-0127281</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">002F57</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Clinical Presentation, Etiology, and Outcome of Infective Endocarditis in the 21st Century : The International Collaboration on Endocarditis-Prospective Cohort Study</title>
<author><name sortKey="Murdoch, David R" sort="Murdoch, David R" uniqKey="Murdoch D" first="David R." last="Murdoch">David R. Murdoch</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Pathology, University of Otago</s1>
<s2>Christchurch</s2>
<s3>NZL</s3>
<sZ>1 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Corey, G Ralph" sort="Corey, G Ralph" uniqKey="Corey G" first="G. Ralph" last="Corey">G. Ralph Corey</name>
<affiliation><inist:fA14 i1="02"><s1>Departments of Medicine, Duke University Medical Center</s1>
<s2>Durham, North Carolina</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="03"><s1>Duke Clinical Research Institute</s1>
<s2>Durham</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Hoen, Bruno" sort="Hoen, Bruno" uniqKey="Hoen B" first="Bruno" last="Hoen">Bruno Hoen</name>
<affiliation><inist:fA14 i1="04"><s1>Departments of Infectious Diseases, Hôpital Saint-Jacques</s1>
<s2>Besancon</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Miro, Jose M" sort="Miro, Jose M" uniqKey="Miro J" first="José M." last="Miro">José M. Miro</name>
<affiliation><inist:fA14 i1="05"><s1>Hospital Clinic-Institut d'lnvestigacions Biomèdiques August Pi I Sunyer, University of Barcelona</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Fowler, Vance G Jr" sort="Fowler, Vance G Jr" uniqKey="Fowler V" first="Vance G. Jr" last="Fowler">Vance G. Jr Fowler</name>
<affiliation><inist:fA14 i1="02"><s1>Departments of Medicine, Duke University Medical Center</s1>
<s2>Durham, North Carolina</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="03"><s1>Duke Clinical Research Institute</s1>
<s2>Durham</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Bayer, Arnold S" sort="Bayer, Arnold S" uniqKey="Bayer A" first="Arnold S." last="Bayer">Arnold S. Bayer</name>
<affiliation><inist:fA14 i1="06"><s1>Divisions of Infectious Diseases, University of California, Los Angeles, Harbor Medical Center</s1>
<s2>Torrance</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Karchmer, Adolf W" sort="Karchmer, Adolf W" uniqKey="Karchmer A" first="Adolf W." last="Karchmer">Adolf W. Karchmer</name>
<affiliation><inist:fA14 i1="02"><s1>Departments of Medicine, Duke University Medical Center</s1>
<s2>Durham, North Carolina</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="07"><s1>Beth Israel-Deaconess Medical Center</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Olaison, Lars" sort="Olaison, Lars" uniqKey="Olaison L" first="Lars" last="Olaison">Lars Olaison</name>
<affiliation><inist:fA14 i1="08"><s1>Sahlgrenska University Hospital</s1>
<s2>Goteborg</s2>
<s3>SWE</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Pappas, Paul A" sort="Pappas, Paul A" uniqKey="Pappas P" first="Paul A." last="Pappas">Paul A. Pappas</name>
<affiliation><inist:fA14 i1="03"><s1>Duke Clinical Research Institute</s1>
<s2>Durham</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Moreillon, Philippe" sort="Moreillon, Philippe" uniqKey="Moreillon P" first="Philippe" last="Moreillon">Philippe Moreillon</name>
<affiliation><inist:fA14 i1="09"><s1>Centre Hospitalier Universitaire, University of Lausanne</s1>
<s2>Lausanne</s2>
<s3>CHE</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Chambers, Stephen T" sort="Chambers, Stephen T" uniqKey="Chambers S" first="Stephen T." last="Chambers">Stephen T. Chambers</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Pathology, University of Otago</s1>
<s2>Christchurch</s2>
<s3>NZL</s3>
<sZ>1 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Chu, Vivian H" sort="Chu, Vivian H" uniqKey="Chu V" first="Vivian H." last="Chu">Vivian H. Chu</name>
<affiliation><inist:fA14 i1="02"><s1>Departments of Medicine, Duke University Medical Center</s1>
<s2>Durham, North Carolina</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Falco, Vicenc" sort="Falco, Vicenc" uniqKey="Falco V" first="Vicenc" last="Falco">Vicenc Falco</name>
<affiliation><inist:fA14 i1="10"><s1>Hospital Universitari Vall D'Hebron</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Holland, David J" sort="Holland, David J" uniqKey="Holland D" first="David J." last="Holland">David J. Holland</name>
<affiliation><inist:fA14 i1="11"><s1>Middlemore Hospital</s1>
<s3>NZL</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Jones, Philip" sort="Jones, Philip" uniqKey="Jones P" first="Philip" last="Jones">Philip Jones</name>
<affiliation><inist:fA14 i1="12"><s1>University of New South Wales</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Klein, John L" sort="Klein, John L" uniqKey="Klein J" first="John L." last="Klein">John L. Klein</name>
<affiliation><inist:fA14 i1="13"><s1>Department of Infection, St Thomas' Hospital</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Raymond, Nigel J" sort="Raymond, Nigel J" uniqKey="Raymond N" first="Nigel J." last="Raymond">Nigel J. Raymond</name>
<affiliation><inist:fA14 i1="14"><s1>Wellington Hospital</s1>
<s2>Wellington</s2>
<s3>NZL</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Read, Kerry M" sort="Read, Kerry M" uniqKey="Read K" first="Kerry M." last="Read">Kerry M. Read</name>
<affiliation><inist:fA14 i1="15"><s1>North Shore Hospital</s1>
<s2>Auckland</s2>
<s3>NZL</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Francoise Tripodi, Marie" sort="Francoise Tripodi, Marie" uniqKey="Francoise Tripodi M" first="Marie" last="Francoise Tripodi">Marie Francoise Tripodi</name>
<affiliation><inist:fA14 i1="16"><s1>Department of Cardiothoracic and Respiratory Services, Second University of Naples</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Utili, Riccardo" sort="Utili, Riccardo" uniqKey="Utili R" first="Riccardo" last="Utili">Riccardo Utili</name>
<affiliation><inist:fA14 i1="16"><s1>Department of Cardiothoracic and Respiratory Services, Second University of Naples</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Wang, Andrew" sort="Wang, Andrew" uniqKey="Wang A" first="Andrew" last="Wang">Andrew Wang</name>
<affiliation><inist:fA14 i1="02"><s1>Departments of Medicine, Duke University Medical Center</s1>
<s2>Durham, North Carolina</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Woods, Christopher W" sort="Woods, Christopher W" uniqKey="Woods C" first="Christopher W." last="Woods">Christopher W. Woods</name>
<affiliation><inist:fA14 i1="02"><s1>Departments of Medicine, Duke University Medical Center</s1>
<s2>Durham, North Carolina</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Cabell, Christopher H" sort="Cabell, Christopher H" uniqKey="Cabell C" first="Christopher H." last="Cabell">Christopher H. Cabell</name>
<affiliation><inist:fA14 i1="02"><s1>Departments of Medicine, Duke University Medical Center</s1>
<s2>Durham, North Carolina</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="03"><s1>Duke Clinical Research Institute</s1>
<s2>Durham</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Archives of internal medicine : (1960)</title>
<title level="j" type="abbreviated">Arch. intern. med. : (1960)</title>
<idno type="ISSN">0003-9926</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Archives of internal medicine : (1960)</title>
<title level="j" type="abbreviated">Arch. intern. med. : (1960)</title>
<idno type="ISSN">0003-9926</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Century 21st</term>
<term>Cohort study</term>
<term>Endocarditis</term>
<term>Etiology</term>
<term>Evolution</term>
<term>Human</term>
<term>International</term>
<term>Medicine</term>
<term>Prognosis</term>
<term>Prospective</term>
<term>Public health</term>
<term>Symptomatology</term>
<term>World</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Endocardite</term>
<term>Symptomatologie</term>
<term>Etiologie</term>
<term>Evolution</term>
<term>Pronostic</term>
<term>Siècle 21eme</term>
<term>International</term>
<term>Monde</term>
<term>Prospective</term>
<term>Etude cohorte</term>
<term>Santé publique</term>
<term>Médecine</term>
<term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background: We sought to provide a contemporary picture of the presentation, etiology, and outcome of infective endocarditis (IE) in a large patient cohort from multiple locations worldwide. Methods: Prospective cohort study of 2781 adults with definite IE who were admitted to 58 hospitals in 25 countries from June 1, 2000, through September 1, 2005. Results: The median age of the cohort was 57.9 (interquartile range, 43.2-71.8) years, and 72.1% had native valve IE. Most patients (77.0%) presented early in the disease (<30 days) with few of the classic clinical hall-marks of IE. Recent health care exposure was found in one-quarter of patients. Staphylococcus aureus was the most common pathogen (31.2%). The mitral (41.1%) and aortic (37.6%) valves were infected most commonly. The following complications were common: stroke (16.9%), embolization other than stroke (22.6%), heart failure (32.3%), and intracardiac abscess (14.4%). Surgical therapy was common (48.2%), and in-hospital mortality remained high (17.7%). Prosthetic valve involvement (odds ratio, 1.47; 95% confidence interval, 1.13-1.90), increasing age (1.30; 1.17-1.46 per 10-year interval), pulmonary edema (1.79; 1.39-2.30), S aureus infection (1.54; 1.14-2.08), coagulase-negative staphylococcal infection (1.50; 1.07-2.10), mitral valve vegetation (1.34; 1.06-1.68), and paravalvular complications (2.25; 1.64-3.09) were associated with an increased risk of in-hospital death, whereas viridans streptococcal infection (0.52; 0.33-0.81) and surgery (0.61; 0.44-0.83) were associated with a decreased risk. Conclusions: In the early 21st century, IE is more often an acute disease, characterized by a high rate of S aureus infection. Mortality remains relatively high.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0003-9926</s0>
</fA01>
<fA02 i1="01"><s0>AIMDAP</s0>
</fA02>
<fA03 i2="1"><s0>Arch. intern. med. : (1960)</s0>
</fA03>
<fA05><s2>169</s2>
</fA05>
<fA06><s2>5</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Clinical Presentation, Etiology, and Outcome of Infective Endocarditis in the 21st Century : The International Collaboration on Endocarditis-Prospective Cohort Study</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>MURDOCH (David R.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>COREY (G. Ralph)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>HOEN (Bruno)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>MIRO (José M.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>FOWLER (Vance G. JR)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>BAYER (Arnold S.)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>KARCHMER (Adolf W.)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>OLAISON (Lars)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>PAPPAS (Paul A.)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>MOREILLON (Philippe)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>CHAMBERS (Stephen T.)</s1>
</fA11>
<fA11 i1="12" i2="1"><s1>CHU (Vivian H.)</s1>
</fA11>
<fA11 i1="13" i2="1"><s1>FALCO (Vicenc)</s1>
</fA11>
<fA11 i1="14" i2="1"><s1>HOLLAND (David J.)</s1>
</fA11>
<fA11 i1="15" i2="1"><s1>JONES (Philip)</s1>
</fA11>
<fA11 i1="16" i2="1"><s1>KLEIN (John L.)</s1>
</fA11>
<fA11 i1="17" i2="1"><s1>RAYMOND (Nigel J.)</s1>
</fA11>
<fA11 i1="18" i2="1"><s1>READ (Kerry M.)</s1>
</fA11>
<fA11 i1="19" i2="1"><s1>FRANCOISE TRIPODI (Marie)</s1>
</fA11>
<fA11 i1="20" i2="1"><s1>UTILI (Riccardo)</s1>
</fA11>
<fA11 i1="21" i2="1"><s1>WANG (Andrew)</s1>
</fA11>
<fA11 i1="22" i2="1"><s1>WOODS (Christopher W.)</s1>
</fA11>
<fA11 i1="23" i2="1"><s1>CABELL (Christopher H.)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Pathology, University of Otago</s1>
<s2>Christchurch</s2>
<s3>NZL</s3>
<sZ>1 aut.</sZ>
<sZ>11 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Departments of Medicine, Duke University Medical Center</s1>
<s2>Durham, North Carolina</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Duke Clinical Research Institute</s1>
<s2>Durham</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>23 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Departments of Infectious Diseases, Hôpital Saint-Jacques</s1>
<s2>Besancon</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Hospital Clinic-Institut d'lnvestigacions Biomèdiques August Pi I Sunyer, University of Barcelona</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Divisions of Infectious Diseases, University of California, Los Angeles, Harbor Medical Center</s1>
<s2>Torrance</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Beth Israel-Deaconess Medical Center</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="08"><s1>Sahlgrenska University Hospital</s1>
<s2>Goteborg</s2>
<s3>SWE</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="09"><s1>Centre Hospitalier Universitaire, University of Lausanne</s1>
<s2>Lausanne</s2>
<s3>CHE</s3>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="10"><s1>Hospital Universitari Vall D'Hebron</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>13 aut.</sZ>
</fA14>
<fA14 i1="11"><s1>Middlemore Hospital</s1>
<s3>NZL</s3>
<sZ>14 aut.</sZ>
</fA14>
<fA14 i1="12"><s1>University of New South Wales</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>15 aut.</sZ>
</fA14>
<fA14 i1="13"><s1>Department of Infection, St Thomas' Hospital</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>16 aut.</sZ>
</fA14>
<fA14 i1="14"><s1>Wellington Hospital</s1>
<s2>Wellington</s2>
<s3>NZL</s3>
<sZ>17 aut.</sZ>
</fA14>
<fA14 i1="15"><s1>North Shore Hospital</s1>
<s2>Auckland</s2>
<s3>NZL</s3>
<sZ>18 aut.</sZ>
</fA14>
<fA14 i1="16"><s1>Department of Cardiothoracic and Respiratory Services, Second University of Naples</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</fA14>
<fA17 i1="01" i2="1"><s1>International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS) Investigators</s1>
<s3>INC</s3>
</fA17>
<fA20><s1>463-473</s1>
</fA20>
<fA21><s1>2009</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>2040</s2>
<s5>354000187278500070</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2009 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>41 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>09-0127281</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Archives of internal medicine : (1960)</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Background: We sought to provide a contemporary picture of the presentation, etiology, and outcome of infective endocarditis (IE) in a large patient cohort from multiple locations worldwide. Methods: Prospective cohort study of 2781 adults with definite IE who were admitted to 58 hospitals in 25 countries from June 1, 2000, through September 1, 2005. Results: The median age of the cohort was 57.9 (interquartile range, 43.2-71.8) years, and 72.1% had native valve IE. Most patients (77.0%) presented early in the disease (<30 days) with few of the classic clinical hall-marks of IE. Recent health care exposure was found in one-quarter of patients. Staphylococcus aureus was the most common pathogen (31.2%). The mitral (41.1%) and aortic (37.6%) valves were infected most commonly. The following complications were common: stroke (16.9%), embolization other than stroke (22.6%), heart failure (32.3%), and intracardiac abscess (14.4%). Surgical therapy was common (48.2%), and in-hospital mortality remained high (17.7%). Prosthetic valve involvement (odds ratio, 1.47; 95% confidence interval, 1.13-1.90), increasing age (1.30; 1.17-1.46 per 10-year interval), pulmonary edema (1.79; 1.39-2.30), S aureus infection (1.54; 1.14-2.08), coagulase-negative staphylococcal infection (1.50; 1.07-2.10), mitral valve vegetation (1.34; 1.06-1.68), and paravalvular complications (2.25; 1.64-3.09) were associated with an increased risk of in-hospital death, whereas viridans streptococcal infection (0.52; 0.33-0.81) and surgery (0.61; 0.44-0.83) were associated with a decreased risk. Conclusions: In the early 21st century, IE is more often an acute disease, characterized by a high rate of S aureus infection. Mortality remains relatively high.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B30A03C</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B01</s0>
</fC02>
<fC02 i1="03" i2="X"><s0>002B12A04</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Endocardite</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Endocarditis</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Endocarditis</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Symptomatologie</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Symptomatology</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Sintomatología</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Etiologie</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Etiology</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Etiología</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Evolution</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Evolution</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Evolución</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Pronostic</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Prognosis</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Pronóstico</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Siècle 21eme</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Century 21st</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Siglo 21</s0>
<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>International</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>International</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Internacional</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Monde</s0>
<s2>NG</s2>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>World</s0>
<s2>NG</s2>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Mundo</s0>
<s2>NG</s2>
<s5>11</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Prospective</s0>
<s5>12</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Prospective</s0>
<s5>12</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Prospectiva</s0>
<s5>12</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Etude cohorte</s0>
<s5>17</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Cohort study</s0>
<s5>17</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Estudio cohorte</s0>
<s5>17</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Santé publique</s0>
<s5>18</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Public health</s0>
<s5>18</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Salud pública</s0>
<s5>18</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Médecine</s0>
<s5>19</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Medicine</s0>
<s5>19</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Medicina</s0>
<s5>19</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Homme</s0>
<s5>25</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Human</s0>
<s5>25</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Hombre</s0>
<s5>25</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'appareil circulatoire</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Cardiovascular disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Aparato circulatorio patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Cardiopathie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Heart disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Cardiopatía</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Pathologie de l'endocarde</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Endocardial disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Endocardio patología</s0>
<s5>39</s5>
</fC07>
<fN21><s1>089</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 09-0127281 INIST</NO>
<ET>Clinical Presentation, Etiology, and Outcome of Infective Endocarditis in the 21st Century : The International Collaboration on Endocarditis-Prospective Cohort Study</ET>
<AU>MURDOCH (David R.); COREY (G. Ralph); HOEN (Bruno); MIRO (José M.); FOWLER (Vance G. JR); BAYER (Arnold S.); KARCHMER (Adolf W.); OLAISON (Lars); PAPPAS (Paul A.); MOREILLON (Philippe); CHAMBERS (Stephen T.); CHU (Vivian H.); FALCO (Vicenc); HOLLAND (David J.); JONES (Philip); KLEIN (John L.); RAYMOND (Nigel J.); READ (Kerry M.); FRANCOISE TRIPODI (Marie); UTILI (Riccardo); WANG (Andrew); WOODS (Christopher W.); CABELL (Christopher H.)</AU>
<AF>Department of Pathology, University of Otago/Christchurch/Nouvelle-Zélande (1 aut., 11 aut.); Departments of Medicine, Duke University Medical Center/Durham, North Carolina/Etats-Unis (2 aut., 5 aut., 7 aut., 12 aut., 21 aut., 22 aut., 23 aut.); Duke Clinical Research Institute/Durham/Etats-Unis (2 aut., 5 aut., 9 aut., 23 aut.); Departments of Infectious Diseases, Hôpital Saint-Jacques/Besancon/France (3 aut.); Hospital Clinic-Institut d'lnvestigacions Biomèdiques August Pi I Sunyer, University of Barcelona/Barcelona/Espagne (4 aut.); Divisions of Infectious Diseases, University of California, Los Angeles, Harbor Medical Center/Torrance/Etats-Unis (6 aut.); Beth Israel-Deaconess Medical Center/Boston, Massachusetts/Etats-Unis (7 aut.); Sahlgrenska University Hospital/Goteborg/Suède (8 aut.); Centre Hospitalier Universitaire, University of Lausanne/Lausanne/Suisse (10 aut.); Hospital Universitari Vall D'Hebron/Barcelona/Espagne (13 aut.); Middlemore Hospital/Nouvelle-Zélande (14 aut.); University of New South Wales/Sydney/Australie (15 aut.); Department of Infection, St Thomas' Hospital/London/Royaume-Uni (16 aut.); Wellington Hospital/Wellington/Nouvelle-Zélande (17 aut.); North Shore Hospital/Auckland/Nouvelle-Zélande (18 aut.); Department of Cardiothoracic and Respiratory Services, Second University of Naples/Naples/Italie (19 aut., 20 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Archives of internal medicine : (1960); ISSN 0003-9926; Coden AIMDAP; Etats-Unis; Da. 2009; Vol. 169; No. 5; Pp. 463-473; Bibl. 41 ref.</SO>
<LA>Anglais</LA>
<EA>Background: We sought to provide a contemporary picture of the presentation, etiology, and outcome of infective endocarditis (IE) in a large patient cohort from multiple locations worldwide. Methods: Prospective cohort study of 2781 adults with definite IE who were admitted to 58 hospitals in 25 countries from June 1, 2000, through September 1, 2005. Results: The median age of the cohort was 57.9 (interquartile range, 43.2-71.8) years, and 72.1% had native valve IE. Most patients (77.0%) presented early in the disease (<30 days) with few of the classic clinical hall-marks of IE. Recent health care exposure was found in one-quarter of patients. Staphylococcus aureus was the most common pathogen (31.2%). The mitral (41.1%) and aortic (37.6%) valves were infected most commonly. The following complications were common: stroke (16.9%), embolization other than stroke (22.6%), heart failure (32.3%), and intracardiac abscess (14.4%). Surgical therapy was common (48.2%), and in-hospital mortality remained high (17.7%). Prosthetic valve involvement (odds ratio, 1.47; 95% confidence interval, 1.13-1.90), increasing age (1.30; 1.17-1.46 per 10-year interval), pulmonary edema (1.79; 1.39-2.30), S aureus infection (1.54; 1.14-2.08), coagulase-negative staphylococcal infection (1.50; 1.07-2.10), mitral valve vegetation (1.34; 1.06-1.68), and paravalvular complications (2.25; 1.64-3.09) were associated with an increased risk of in-hospital death, whereas viridans streptococcal infection (0.52; 0.33-0.81) and surgery (0.61; 0.44-0.83) were associated with a decreased risk. Conclusions: In the early 21st century, IE is more often an acute disease, characterized by a high rate of S aureus infection. Mortality remains relatively high.</EA>
<CC>002B30A03C; 002B01; 002B12A04</CC>
<FD>Endocardite; Symptomatologie; Etiologie; Evolution; Pronostic; Siècle 21eme; International; Monde; Prospective; Etude cohorte; Santé publique; Médecine; Homme</FD>
<FG>Pathologie de l'appareil circulatoire; Cardiopathie; Pathologie de l'endocarde</FG>
<ED>Endocarditis; Symptomatology; Etiology; Evolution; Prognosis; Century 21st; International; World; Prospective; Cohort study; Public health; Medicine; Human</ED>
<EG>Cardiovascular disease; Heart disease; Endocardial disease</EG>
<SD>Endocarditis; Sintomatología; Etiología; Evolución; Pronóstico; Siglo 21; Internacional; Mundo; Prospectiva; Estudio cohorte; Salud pública; Medicina; Hombre</SD>
<LO>INIST-2040.354000187278500070</LO>
<ID>09-0127281</ID>
</server>
</inist>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PascalFrancis/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002F57 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Corpus/biblio.hfd -nk 002F57 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= PascalFrancis |étape= Corpus |type= RBID |clé= Pascal:09-0127281 |texte= Clinical Presentation, Etiology, and Outcome of Infective Endocarditis in the 21st Century : The International Collaboration on Endocarditis-Prospective Cohort Study }}
This area was generated with Dilib version V0.6.33. |