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Revisiting the effect of referral bias on the clinical spectrum of infective endocarditis in adults

Identifieur interne : 002308 ( PascalFrancis/Corpus ); précédent : 002307; suivant : 002309

Revisiting the effect of referral bias on the clinical spectrum of infective endocarditis in adults

Auteurs : Z. A. Kanafani ; S. S. Kanj ; C. H. Cabell ; E. Cecchi ; A. De Oliveira Ramos ; T. Lejko-Zupanc ; P. A. Pappas ; H. Giamerellou ; D. Gordon ; C. Michelet ; P. Munoz ; O. Pachirat ; G. Peterson ; R.-S. Tan ; P. Tattevin ; V. Thomas ; A. Wang ; F. Wiesbauer ; D. J. Sexton

Source :

RBID : Pascal:10-0472003

Descripteurs français

English descriptors

Abstract

Referral bias occurs because of the clustering of patients at tertiary care centers. This may result in the distortion of observed clinical manifestations of rare diseases. This analysis evaluates the effect of referral bias on the epidemiology of infective endocarditis (IE) in the International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS). This is a prospective multicenter cohort study comparing transferred and non-transferred patients with IE. Factors independently associated with transfer status were evaluated using multivariable logistic regression. A total of 2,760 patients were included in the analysis, of which 1,164 (42.2%) were transferred from other medical centers. Transferred patients more often underwent surgery for IE (odds ratio [OR]=2.5; 95% confidence interval [CI] 1.9-3.2). They were also more likely to have complications such as stroke (OR=1.5; 95% CI 1.3-1.9), heart failure (OR=1.4; 95% CI 1.1-1.6), and new valvular regurgitation (OR=1.3; 95% CI 1.1-1.6). The in-hospital mortality rates were similar in both groups. Patients with IE who require surgery and suffer complications are referred to tertiary hospitals more frequently than patients with an uncomplicated course. Hospital transfer has no obvious effect on the in-hospital mortality. Referral bias should be taken into consideration when describing the clinical spectrum of IE.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

pA  
A01 01  1    @0 0934-9723
A03   1    @0 Eur. j. clin. microbiol. infect. dis. : (Print)
A05       @2 29
A06       @2 10
A08 01  1  ENG  @1 Revisiting the effect of referral bias on the clinical spectrum of infective endocarditis in adults
A11 01  1    @1 KANAFANI (Z. A.)
A11 02  1    @1 KANJ (S. S.)
A11 03  1    @1 CABELL (C. H.)
A11 04  1    @1 CECCHI (E.)
A11 05  1    @1 DE OLIVEIRA RAMOS (A.)
A11 06  1    @1 LEJKO-ZUPANC (T.)
A11 07  1    @1 PAPPAS (P. A.)
A11 08  1    @1 GIAMERELLOU (H.)
A11 09  1    @1 GORDON (D.)
A11 10  1    @1 MICHELET (C.)
A11 11  1    @1 MUNOZ (P.)
A11 12  1    @1 PACHIRAT (O.)
A11 13  1    @1 PETERSON (G.)
A11 14  1    @1 TAN (R.-S.)
A11 15  1    @1 TATTEVIN (P.)
A11 16  1    @1 THOMAS (V.)
A11 17  1    @1 WANG (A.)
A11 18  1    @1 WIESBAUER (F.)
A11 19  1    @1 SEXTON (D. J.)
A14 01      @1 American University of Beirut Medical Center @2 Beirut @3 LBN @Z 1 aut. @Z 2 aut.
A14 02      @1 Duke University Medical Center @2 Durham, NC @3 USA @Z 3 aut. @Z 17 aut. @Z 19 aut.
A14 03      @1 Duke Clinical Research Institute @2 Durham, NC @3 USA @Z 3 aut. @Z 7 aut.
A14 04      @1 Maria Vittoria Hospital @2 Turin @3 ITA @Z 4 aut.
A14 05      @1 Instituto Dante Pazzanese de Cardiologia @2 Moema @3 BRA @Z 5 aut.
A14 06      @1 Medical Center Ljubljana @2 Ljubljana @3 SVN @Z 6 aut.
A14 07      @1 Attikon University General Hospital @2 Athens @3 GRC @Z 8 aut.
A14 08      @1 Flinders Medical Centre @2 Adelaide @3 AUS @Z 9 aut.
A14 09      @1 Pontchaillou University @2 Rennes @3 FRA @Z 10 aut. @Z 15 aut.
A14 10      @1 Hospital General Universitario Gregorio Marañón @2 Madrid @3 ESP @Z 11 aut.
A14 11      @1 Khon Kaen University @2 Khon Kaen @3 THA @Z 12 aut.
A14 12      @1 University of Texas Southwestern Medical Center @2 Dallas, TX @3 USA @Z 13 aut.
A14 13      @1 National Heart Centre @2 Singapore @3 SGP @Z 14 aut.
A14 14      @1 Medical College Calicut @2 Kerala @3 IND @Z 16 aut.
A14 15      @1 Vienna General Hospital @2 Vienna @3 AUT @Z 18 aut.
A20       @1 1203-1210
A21       @1 2010
A23 01      @0 ENG
A43 01      @1 INIST @2 19903 @5 354000191298580030
A44       @0 0000 @1 © 2010 INIST-CNRS. All rights reserved.
A45       @0 32 ref.
A47 01  1    @0 10-0472003
A60       @1 P
A61       @0 A
A64 01  1    @0 European journal of clinical microbiology & infectious diseases : (Print)
A66 01      @0 DEU
C01 01    ENG  @0 Referral bias occurs because of the clustering of patients at tertiary care centers. This may result in the distortion of observed clinical manifestations of rare diseases. This analysis evaluates the effect of referral bias on the epidemiology of infective endocarditis (IE) in the International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS). This is a prospective multicenter cohort study comparing transferred and non-transferred patients with IE. Factors independently associated with transfer status were evaluated using multivariable logistic regression. A total of 2,760 patients were included in the analysis, of which 1,164 (42.2%) were transferred from other medical centers. Transferred patients more often underwent surgery for IE (odds ratio [OR]=2.5; 95% confidence interval [CI] 1.9-3.2). They were also more likely to have complications such as stroke (OR=1.5; 95% CI 1.3-1.9), heart failure (OR=1.4; 95% CI 1.1-1.6), and new valvular regurgitation (OR=1.3; 95% CI 1.1-1.6). The in-hospital mortality rates were similar in both groups. Patients with IE who require surgery and suffer complications are referred to tertiary hospitals more frequently than patients with an uncomplicated course. Hospital transfer has no obvious effect on the in-hospital mortality. Referral bias should be taken into consideration when describing the clinical spectrum of IE.
C02 01  X    @0 002B05
C02 02  X    @0 002B12A04
C03 01  X  FRE  @0 Endocardite @5 01
C03 01  X  ENG  @0 Endocarditis @5 01
C03 01  X  SPA  @0 Endocarditis @5 01
C03 02  X  FRE  @0 Symptomatologie @5 07
C03 02  X  ENG  @0 Symptomatology @5 07
C03 02  X  SPA  @0 Sintomatología @5 07
C03 03  X  FRE  @0 Adulte @5 08
C03 03  X  ENG  @0 Adult @5 08
C03 03  X  SPA  @0 Adulto @5 08
C03 04  X  FRE  @0 Infection @5 09
C03 04  X  ENG  @0 Infection @5 09
C03 04  X  SPA  @0 Infección @5 09
C03 05  X  FRE  @0 Microbiologie @5 13
C03 05  X  ENG  @0 Microbiology @5 13
C03 05  X  SPA  @0 Microbiología @5 13
C07 01  X  FRE  @0 Homme
C07 01  X  ENG  @0 Human
C07 01  X  SPA  @0 Hombre
C07 02  X  FRE  @0 Pathologie de l'appareil circulatoire @5 37
C07 02  X  ENG  @0 Cardiovascular disease @5 37
C07 02  X  SPA  @0 Aparato circulatorio patología @5 37
C07 03  X  FRE  @0 Cardiopathie @5 38
C07 03  X  ENG  @0 Heart disease @5 38
C07 03  X  SPA  @0 Cardiopatía @5 38
C07 04  X  FRE  @0 Pathologie de l'endocarde @5 39
C07 04  X  ENG  @0 Endocardial disease @5 39
C07 04  X  SPA  @0 Endocardio patología @5 39
N21       @1 305
N44 01      @1 OTO
N82       @1 OTO

Format Inist (serveur)

NO : PASCAL 10-0472003 INIST
ET : Revisiting the effect of referral bias on the clinical spectrum of infective endocarditis in adults
AU : KANAFANI (Z. A.); KANJ (S. S.); CABELL (C. H.); CECCHI (E.); DE OLIVEIRA RAMOS (A.); LEJKO-ZUPANC (T.); PAPPAS (P. A.); GIAMERELLOU (H.); GORDON (D.); MICHELET (C.); MUNOZ (P.); PACHIRAT (O.); PETERSON (G.); TAN (R.-S.); TATTEVIN (P.); THOMAS (V.); WANG (A.); WIESBAUER (F.); SEXTON (D. J.)
AF : American University of Beirut Medical Center/Beirut/Liban (1 aut., 2 aut.); Duke University Medical Center/Durham, NC/Etats-Unis (3 aut., 17 aut., 19 aut.); Duke Clinical Research Institute/Durham, NC/Etats-Unis (3 aut., 7 aut.); Maria Vittoria Hospital/Turin/Italie (4 aut.); Instituto Dante Pazzanese de Cardiologia/Moema/Brésil (5 aut.); Medical Center Ljubljana/Ljubljana/Slovénie (6 aut.); Attikon University General Hospital/Athens/Grèce (8 aut.); Flinders Medical Centre/Adelaide/Australie (9 aut.); Pontchaillou University/Rennes/France (10 aut., 15 aut.); Hospital General Universitario Gregorio Marañón/Madrid/Espagne (11 aut.); Khon Kaen University/Khon Kaen/Thaïlande (12 aut.); University of Texas Southwestern Medical Center/Dallas, TX/Etats-Unis (13 aut.); National Heart Centre/Singapore/Singapour (14 aut.); Medical College Calicut/Kerala/Inde (16 aut.); Vienna General Hospital/Vienna/Autriche (18 aut.)
DT : Publication en série; Niveau analytique
SO : European journal of clinical microbiology & infectious diseases : (Print); ISSN 0934-9723; Allemagne; Da. 2010; Vol. 29; No. 10; Pp. 1203-1210; Bibl. 32 ref.
LA : Anglais
EA : Referral bias occurs because of the clustering of patients at tertiary care centers. This may result in the distortion of observed clinical manifestations of rare diseases. This analysis evaluates the effect of referral bias on the epidemiology of infective endocarditis (IE) in the International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS). This is a prospective multicenter cohort study comparing transferred and non-transferred patients with IE. Factors independently associated with transfer status were evaluated using multivariable logistic regression. A total of 2,760 patients were included in the analysis, of which 1,164 (42.2%) were transferred from other medical centers. Transferred patients more often underwent surgery for IE (odds ratio [OR]=2.5; 95% confidence interval [CI] 1.9-3.2). They were also more likely to have complications such as stroke (OR=1.5; 95% CI 1.3-1.9), heart failure (OR=1.4; 95% CI 1.1-1.6), and new valvular regurgitation (OR=1.3; 95% CI 1.1-1.6). The in-hospital mortality rates were similar in both groups. Patients with IE who require surgery and suffer complications are referred to tertiary hospitals more frequently than patients with an uncomplicated course. Hospital transfer has no obvious effect on the in-hospital mortality. Referral bias should be taken into consideration when describing the clinical spectrum of IE.
CC : 002B05; 002B12A04
FD : Endocardite; Symptomatologie; Adulte; Infection; Microbiologie
FG : Homme; Pathologie de l'appareil circulatoire; Cardiopathie; Pathologie de l'endocarde
ED : Endocarditis; Symptomatology; Adult; Infection; Microbiology
EG : Human; Cardiovascular disease; Heart disease; Endocardial disease
SD : Endocarditis; Sintomatología; Adulto; Infección; Microbiología
LO : INIST-19903.354000191298580030
ID : 10-0472003

Links to Exploration step

Pascal:10-0472003

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<div type="abstract" xml:lang="en">Referral bias occurs because of the clustering of patients at tertiary care centers. This may result in the distortion of observed clinical manifestations of rare diseases. This analysis evaluates the effect of referral bias on the epidemiology of infective endocarditis (IE) in the International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS). This is a prospective multicenter cohort study comparing transferred and non-transferred patients with IE. Factors independently associated with transfer status were evaluated using multivariable logistic regression. A total of 2,760 patients were included in the analysis, of which 1,164 (42.2%) were transferred from other medical centers. Transferred patients more often underwent surgery for IE (odds ratio [OR]=2.5; 95% confidence interval [CI] 1.9-3.2). They were also more likely to have complications such as stroke (OR=1.5; 95% CI 1.3-1.9), heart failure (OR=1.4; 95% CI 1.1-1.6), and new valvular regurgitation (OR=1.3; 95% CI 1.1-1.6). The in-hospital mortality rates were similar in both groups. Patients with IE who require surgery and suffer complications are referred to tertiary hospitals more frequently than patients with an uncomplicated course. Hospital transfer has no obvious effect on the in-hospital mortality. Referral bias should be taken into consideration when describing the clinical spectrum of IE.</div>
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