Revisiting the effect of referral bias on the clinical spectrum of infective endocarditis in adults
Identifieur interne : 002308 ( PascalFrancis/Corpus ); précédent : 002307; suivant : 002309Revisiting the effect of referral bias on the clinical spectrum of infective endocarditis in adults
Auteurs : Z. A. Kanafani ; S. S. Kanj ; C. H. Cabell ; E. Cecchi ; A. De Oliveira Ramos ; T. Lejko-Zupanc ; P. A. Pappas ; H. Giamerellou ; D. Gordon ; C. Michelet ; P. Munoz ; O. Pachirat ; G. Peterson ; R.-S. Tan ; P. Tattevin ; V. Thomas ; A. Wang ; F. Wiesbauer ; D. J. SextonSource :
- European journal of clinical microbiology & infectious diseases : (Print) [ 0934-9723 ] ; 2010.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Referral bias occurs because of the clustering of patients at tertiary care centers. This may result in the distortion of observed clinical manifestations of rare diseases. This analysis evaluates the effect of referral bias on the epidemiology of infective endocarditis (IE) in the International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS). This is a prospective multicenter cohort study comparing transferred and non-transferred patients with IE. Factors independently associated with transfer status were evaluated using multivariable logistic regression. A total of 2,760 patients were included in the analysis, of which 1,164 (42.2%) were transferred from other medical centers. Transferred patients more often underwent surgery for IE (odds ratio [OR]=2.5; 95% confidence interval [CI] 1.9-3.2). They were also more likely to have complications such as stroke (OR=1.5; 95% CI 1.3-1.9), heart failure (OR=1.4; 95% CI 1.1-1.6), and new valvular regurgitation (OR=1.3; 95% CI 1.1-1.6). The in-hospital mortality rates were similar in both groups. Patients with IE who require surgery and suffer complications are referred to tertiary hospitals more frequently than patients with an uncomplicated course. Hospital transfer has no obvious effect on the in-hospital mortality. Referral bias should be taken into consideration when describing the clinical spectrum of IE.
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Format Inist (serveur)
NO : | PASCAL 10-0472003 INIST |
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ET : | Revisiting the effect of referral bias on the clinical spectrum of infective endocarditis in adults |
AU : | KANAFANI (Z. A.); KANJ (S. S.); CABELL (C. H.); CECCHI (E.); DE OLIVEIRA RAMOS (A.); LEJKO-ZUPANC (T.); PAPPAS (P. A.); GIAMERELLOU (H.); GORDON (D.); MICHELET (C.); MUNOZ (P.); PACHIRAT (O.); PETERSON (G.); TAN (R.-S.); TATTEVIN (P.); THOMAS (V.); WANG (A.); WIESBAUER (F.); SEXTON (D. J.) |
AF : | American University of Beirut Medical Center/Beirut/Liban (1 aut., 2 aut.); Duke University Medical Center/Durham, NC/Etats-Unis (3 aut., 17 aut., 19 aut.); Duke Clinical Research Institute/Durham, NC/Etats-Unis (3 aut., 7 aut.); Maria Vittoria Hospital/Turin/Italie (4 aut.); Instituto Dante Pazzanese de Cardiologia/Moema/Brésil (5 aut.); Medical Center Ljubljana/Ljubljana/Slovénie (6 aut.); Attikon University General Hospital/Athens/Grèce (8 aut.); Flinders Medical Centre/Adelaide/Australie (9 aut.); Pontchaillou University/Rennes/France (10 aut., 15 aut.); Hospital General Universitario Gregorio Marañón/Madrid/Espagne (11 aut.); Khon Kaen University/Khon Kaen/Thaïlande (12 aut.); University of Texas Southwestern Medical Center/Dallas, TX/Etats-Unis (13 aut.); National Heart Centre/Singapore/Singapour (14 aut.); Medical College Calicut/Kerala/Inde (16 aut.); Vienna General Hospital/Vienna/Autriche (18 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | European journal of clinical microbiology & infectious diseases : (Print); ISSN 0934-9723; Allemagne; Da. 2010; Vol. 29; No. 10; Pp. 1203-1210; Bibl. 32 ref. |
LA : | Anglais |
EA : | Referral bias occurs because of the clustering of patients at tertiary care centers. This may result in the distortion of observed clinical manifestations of rare diseases. This analysis evaluates the effect of referral bias on the epidemiology of infective endocarditis (IE) in the International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS). This is a prospective multicenter cohort study comparing transferred and non-transferred patients with IE. Factors independently associated with transfer status were evaluated using multivariable logistic regression. A total of 2,760 patients were included in the analysis, of which 1,164 (42.2%) were transferred from other medical centers. Transferred patients more often underwent surgery for IE (odds ratio [OR]=2.5; 95% confidence interval [CI] 1.9-3.2). They were also more likely to have complications such as stroke (OR=1.5; 95% CI 1.3-1.9), heart failure (OR=1.4; 95% CI 1.1-1.6), and new valvular regurgitation (OR=1.3; 95% CI 1.1-1.6). The in-hospital mortality rates were similar in both groups. Patients with IE who require surgery and suffer complications are referred to tertiary hospitals more frequently than patients with an uncomplicated course. Hospital transfer has no obvious effect on the in-hospital mortality. Referral bias should be taken into consideration when describing the clinical spectrum of IE. |
CC : | 002B05; 002B12A04 |
FD : | Endocardite; Symptomatologie; Adulte; Infection; Microbiologie |
FG : | Homme; Pathologie de l'appareil circulatoire; Cardiopathie; Pathologie de l'endocarde |
ED : | Endocarditis; Symptomatology; Adult; Infection; Microbiology |
EG : | Human; Cardiovascular disease; Heart disease; Endocardial disease |
SD : | Endocarditis; Sintomatología; Adulto; Infección; Microbiología |
LO : | INIST-19903.354000191298580030 |
ID : | 10-0472003 |
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Pascal:10-0472003Le document en format XML
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<front><div type="abstract" xml:lang="en">Referral bias occurs because of the clustering of patients at tertiary care centers. This may result in the distortion of observed clinical manifestations of rare diseases. This analysis evaluates the effect of referral bias on the epidemiology of infective endocarditis (IE) in the International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS). This is a prospective multicenter cohort study comparing transferred and non-transferred patients with IE. Factors independently associated with transfer status were evaluated using multivariable logistic regression. A total of 2,760 patients were included in the analysis, of which 1,164 (42.2%) were transferred from other medical centers. Transferred patients more often underwent surgery for IE (odds ratio [OR]=2.5; 95% confidence interval [CI] 1.9-3.2). They were also more likely to have complications such as stroke (OR=1.5; 95% CI 1.3-1.9), heart failure (OR=1.4; 95% CI 1.1-1.6), and new valvular regurgitation (OR=1.3; 95% CI 1.1-1.6). The in-hospital mortality rates were similar in both groups. Patients with IE who require surgery and suffer complications are referred to tertiary hospitals more frequently than patients with an uncomplicated course. Hospital transfer has no obvious effect on the in-hospital mortality. Referral bias should be taken into consideration when describing the clinical spectrum of IE.</div>
</front>
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<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0934-9723</s0>
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<fA03 i2="1"><s0>Eur. j. clin. microbiol. infect. dis. : (Print)</s0>
</fA03>
<fA05><s2>29</s2>
</fA05>
<fA06><s2>10</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Revisiting the effect of referral bias on the clinical spectrum of infective endocarditis in adults</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>KANAFANI (Z. A.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>KANJ (S. S.)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>CABELL (C. H.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>CECCHI (E.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>DE OLIVEIRA RAMOS (A.)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>LEJKO-ZUPANC (T.)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>PAPPAS (P. A.)</s1>
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<fA11 i1="08" i2="1"><s1>GIAMERELLOU (H.)</s1>
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<fA11 i1="09" i2="1"><s1>GORDON (D.)</s1>
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<fA11 i1="10" i2="1"><s1>MICHELET (C.)</s1>
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<fA11 i1="11" i2="1"><s1>MUNOZ (P.)</s1>
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<fA11 i1="12" i2="1"><s1>PACHIRAT (O.)</s1>
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<fA11 i1="13" i2="1"><s1>PETERSON (G.)</s1>
</fA11>
<fA11 i1="14" i2="1"><s1>TAN (R.-S.)</s1>
</fA11>
<fA11 i1="15" i2="1"><s1>TATTEVIN (P.)</s1>
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<fA11 i1="16" i2="1"><s1>THOMAS (V.)</s1>
</fA11>
<fA11 i1="17" i2="1"><s1>WANG (A.)</s1>
</fA11>
<fA11 i1="18" i2="1"><s1>WIESBAUER (F.)</s1>
</fA11>
<fA11 i1="19" i2="1"><s1>SEXTON (D. J.)</s1>
</fA11>
<fA14 i1="01"><s1>American University of Beirut Medical Center</s1>
<s2>Beirut</s2>
<s3>LBN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Duke University Medical Center</s1>
<s2>Durham, NC</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>19 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Duke Clinical Research Institute</s1>
<s2>Durham, NC</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Maria Vittoria Hospital</s1>
<s2>Turin</s2>
<s3>ITA</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Instituto Dante Pazzanese de Cardiologia</s1>
<s2>Moema</s2>
<s3>BRA</s3>
<sZ>5 aut.</sZ>
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<fA14 i1="06"><s1>Medical Center Ljubljana</s1>
<s2>Ljubljana</s2>
<s3>SVN</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Attikon University General Hospital</s1>
<s2>Athens</s2>
<s3>GRC</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="08"><s1>Flinders Medical Centre</s1>
<s2>Adelaide</s2>
<s3>AUS</s3>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="09"><s1>Pontchaillou University</s1>
<s2>Rennes</s2>
<s3>FRA</s3>
<sZ>10 aut.</sZ>
<sZ>15 aut.</sZ>
</fA14>
<fA14 i1="10"><s1>Hospital General Universitario Gregorio Marañón</s1>
<s2>Madrid</s2>
<s3>ESP</s3>
<sZ>11 aut.</sZ>
</fA14>
<fA14 i1="11"><s1>Khon Kaen University</s1>
<s2>Khon Kaen</s2>
<s3>THA</s3>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="12"><s1>University of Texas Southwestern Medical Center</s1>
<s2>Dallas, TX</s2>
<s3>USA</s3>
<sZ>13 aut.</sZ>
</fA14>
<fA14 i1="13"><s1>National Heart Centre</s1>
<s2>Singapore</s2>
<s3>SGP</s3>
<sZ>14 aut.</sZ>
</fA14>
<fA14 i1="14"><s1>Medical College Calicut</s1>
<s2>Kerala</s2>
<s3>IND</s3>
<sZ>16 aut.</sZ>
</fA14>
<fA14 i1="15"><s1>Vienna General Hospital</s1>
<s2>Vienna</s2>
<s3>AUT</s3>
<sZ>18 aut.</sZ>
</fA14>
<fA20><s1>1203-1210</s1>
</fA20>
<fA21><s1>2010</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>19903</s2>
<s5>354000191298580030</s5>
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<fA44><s0>0000</s0>
<s1>© 2010 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>32 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>10-0472003</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>European journal of clinical microbiology & infectious diseases : (Print)</s0>
</fA64>
<fA66 i1="01"><s0>DEU</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Referral bias occurs because of the clustering of patients at tertiary care centers. This may result in the distortion of observed clinical manifestations of rare diseases. This analysis evaluates the effect of referral bias on the epidemiology of infective endocarditis (IE) in the International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS). This is a prospective multicenter cohort study comparing transferred and non-transferred patients with IE. Factors independently associated with transfer status were evaluated using multivariable logistic regression. A total of 2,760 patients were included in the analysis, of which 1,164 (42.2%) were transferred from other medical centers. Transferred patients more often underwent surgery for IE (odds ratio [OR]=2.5; 95% confidence interval [CI] 1.9-3.2). They were also more likely to have complications such as stroke (OR=1.5; 95% CI 1.3-1.9), heart failure (OR=1.4; 95% CI 1.1-1.6), and new valvular regurgitation (OR=1.3; 95% CI 1.1-1.6). The in-hospital mortality rates were similar in both groups. Patients with IE who require surgery and suffer complications are referred to tertiary hospitals more frequently than patients with an uncomplicated course. Hospital transfer has no obvious effect on the in-hospital mortality. Referral bias should be taken into consideration when describing the clinical spectrum of IE.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B05</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B12A04</s0>
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<fC03 i1="01" i2="X" l="FRE"><s0>Endocardite</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Endocarditis</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Endocarditis</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Symptomatologie</s0>
<s5>07</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Symptomatology</s0>
<s5>07</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Sintomatología</s0>
<s5>07</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Adulte</s0>
<s5>08</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Adult</s0>
<s5>08</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Adulto</s0>
<s5>08</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Infection</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Infection</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Infección</s0>
<s5>09</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Microbiologie</s0>
<s5>13</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Microbiology</s0>
<s5>13</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Microbiología</s0>
<s5>13</s5>
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<fC07 i1="01" i2="X" l="FRE"><s0>Homme</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Human</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Hombre</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Pathologie de l'appareil circulatoire</s0>
<s5>37</s5>
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<fC07 i1="02" i2="X" l="ENG"><s0>Cardiovascular disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Aparato circulatorio patología</s0>
<s5>37</s5>
</fC07>
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<s5>38</s5>
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<fC07 i1="03" i2="X" l="ENG"><s0>Heart disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Cardiopatía</s0>
<s5>38</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Pathologie de l'endocarde</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Endocardial disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Endocardio patología</s0>
<s5>39</s5>
</fC07>
<fN21><s1>305</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
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<fN82><s1>OTO</s1>
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<server><NO>PASCAL 10-0472003 INIST</NO>
<ET>Revisiting the effect of referral bias on the clinical spectrum of infective endocarditis in adults</ET>
<AU>KANAFANI (Z. A.); KANJ (S. S.); CABELL (C. H.); CECCHI (E.); DE OLIVEIRA RAMOS (A.); LEJKO-ZUPANC (T.); PAPPAS (P. A.); GIAMERELLOU (H.); GORDON (D.); MICHELET (C.); MUNOZ (P.); PACHIRAT (O.); PETERSON (G.); TAN (R.-S.); TATTEVIN (P.); THOMAS (V.); WANG (A.); WIESBAUER (F.); SEXTON (D. J.)</AU>
<AF>American University of Beirut Medical Center/Beirut/Liban (1 aut., 2 aut.); Duke University Medical Center/Durham, NC/Etats-Unis (3 aut., 17 aut., 19 aut.); Duke Clinical Research Institute/Durham, NC/Etats-Unis (3 aut., 7 aut.); Maria Vittoria Hospital/Turin/Italie (4 aut.); Instituto Dante Pazzanese de Cardiologia/Moema/Brésil (5 aut.); Medical Center Ljubljana/Ljubljana/Slovénie (6 aut.); Attikon University General Hospital/Athens/Grèce (8 aut.); Flinders Medical Centre/Adelaide/Australie (9 aut.); Pontchaillou University/Rennes/France (10 aut., 15 aut.); Hospital General Universitario Gregorio Marañón/Madrid/Espagne (11 aut.); Khon Kaen University/Khon Kaen/Thaïlande (12 aut.); University of Texas Southwestern Medical Center/Dallas, TX/Etats-Unis (13 aut.); National Heart Centre/Singapore/Singapour (14 aut.); Medical College Calicut/Kerala/Inde (16 aut.); Vienna General Hospital/Vienna/Autriche (18 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>European journal of clinical microbiology & infectious diseases : (Print); ISSN 0934-9723; Allemagne; Da. 2010; Vol. 29; No. 10; Pp. 1203-1210; Bibl. 32 ref.</SO>
<LA>Anglais</LA>
<EA>Referral bias occurs because of the clustering of patients at tertiary care centers. This may result in the distortion of observed clinical manifestations of rare diseases. This analysis evaluates the effect of referral bias on the epidemiology of infective endocarditis (IE) in the International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS). This is a prospective multicenter cohort study comparing transferred and non-transferred patients with IE. Factors independently associated with transfer status were evaluated using multivariable logistic regression. A total of 2,760 patients were included in the analysis, of which 1,164 (42.2%) were transferred from other medical centers. Transferred patients more often underwent surgery for IE (odds ratio [OR]=2.5; 95% confidence interval [CI] 1.9-3.2). They were also more likely to have complications such as stroke (OR=1.5; 95% CI 1.3-1.9), heart failure (OR=1.4; 95% CI 1.1-1.6), and new valvular regurgitation (OR=1.3; 95% CI 1.1-1.6). The in-hospital mortality rates were similar in both groups. Patients with IE who require surgery and suffer complications are referred to tertiary hospitals more frequently than patients with an uncomplicated course. Hospital transfer has no obvious effect on the in-hospital mortality. Referral bias should be taken into consideration when describing the clinical spectrum of IE.</EA>
<CC>002B05; 002B12A04</CC>
<FD>Endocardite; Symptomatologie; Adulte; Infection; Microbiologie</FD>
<FG>Homme; Pathologie de l'appareil circulatoire; Cardiopathie; Pathologie de l'endocarde</FG>
<ED>Endocarditis; Symptomatology; Adult; Infection; Microbiology</ED>
<EG>Human; Cardiovascular disease; Heart disease; Endocardial disease</EG>
<SD>Endocarditis; Sintomatología; Adulto; Infección; Microbiología</SD>
<LO>INIST-19903.354000191298580030</LO>
<ID>10-0472003</ID>
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