AustralieFrV1, PascalFrancis, Corpus, bibRecord, 002214

Executive functions in recently postmenopausal women: Absence of strong association with serum gonadal steroids

Identifieur interne : 002214 ( PascalFrancis/Corpus ); précédent : 002213; suivant : 002215

Executive functions in recently postmenopausal women: Absence of strong association with serum gonadal steroids

Auteurs : Joanne Ryan ; Frank Z. Stanczyk ; Lorraine Dennerstein ; Wendy J. Mack ; Margaret S. Clark ; Cassandra Szoeke ; Victor W. Henderson

Source :

Brain research [ 0006-8993 ] ; 2011.

RBID : Francis:11-0224964

Descripteurs français

Pascal (Inist)
- Fonction exécutive, Postménopause, Femelle, Stéroïde, Cognition, Estradiol, Oestrogène, Ménopause, Testostérone, Mémoire de travail, Homme, Femme.

English descriptors

KwdEn :
- Cognition, Estradiol, Estrogen, Executive function, Female, Human, Menopause, Postmenopause, Steroid, Testosterone, Woman, Working memory.

Abstract

It is controversial to what extent endogenous gonadal hormone exposures influence executive functions in midlife women. Participants in the population-based Melbourne Women's Midlife Health Project were administered a battery of neuropsychological tests on two occasions 2 years apart. Tests of executive functions were the Trail Making Test (Part B), Tower of London (administered at baseline only), Symbol Digit Modalities Test, Digit Span Backward, and Letter-Number Sequencing. Estrone, free estradiol, and free testosterone levels were measured at the time of the first testing, and analyses were restricted to 147 women aged 56-64 years who had recently undergone natural menopause (mean age of menopause 53 years) and were not using hormone therapy. In multiple linear regression analyses, 2 of 20 baseline associations were significant at an alpha level of 0.05. Estrone concentrations were positively associated with Tower of London performance (p = 0.02), and the ratio of free testosterone to free estradiol was positively associated with scores on the Symbol Digit Modalities Test score (p=0.04). No hormone measure was significantly predictive of 2-year change in executive functions performance. Significance levels in these exploratory analyses were unadjusted for multiple comparisons, and observed associations could be due to unique psychometric properties of these particular tasks or due to chance. Sex hormone binding globulin concentrations were unrelated to executive function scores. In recently postmenopausal women not receiving hormone therapy, serum concentrations of estrone, estradiol and testosterone, and the testosterone/estradiol ratio are not strongly associated with executive functions.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	FRANCIS 11-0224964 INIST
ET :	Executive functions in recently postmenopausal women: Absence of strong association with serum gonadal steroids
AU :	RYAN (Joanne); STANCZYK (Frank Z.); DENNERSTEIN (Lorraine); MACK (Wendy J.); CLARK (Margaret S.); SZOEKE (Cassandra); HENDERSON (Victor W.); MILNER (Teresa A.)
AF :	Department of Psychiatry, The University of Melbourne/Parkville, Victoria 3010/Australie (1 aut., 3 aut., 5 aut., 6 aut.); National Ageing Research Institute, The University of Melbourne/Parkville, Victoria 3010/Australie (1 aut., 3 aut.); Inserm, U888, Montpellier F-34093, France, Univ Montpellier1/Montpellier F-34000/France (1 aut.); Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California/Los Angeles, CA 90033/Etats-Unis (2 aut.); Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Los Angeles, CA 90033/Etats-Unis (4 aut.); Departments of Health Research and Policy (Epidemiology) and of Neurology and Neurological Sciences, Stanford University/Stanford, CA 94305/Etats-Unis (7 aut.); Weil Cornell Medical College/New York/Etats-Unis (1 aut.)
DT :	Publication en série; Congrès; Niveau analytique
SO :	Brain research; ISSN 0006-8993; Coden BRREAP; Pays-Bas; Da. 2011; Vol. 1379; Pp. 199-205; Bibl. 3/4 p.
LA :	Anglais
EA :	It is controversial to what extent endogenous gonadal hormone exposures influence executive functions in midlife women. Participants in the population-based Melbourne Women's Midlife Health Project were administered a battery of neuropsychological tests on two occasions 2 years apart. Tests of executive functions were the Trail Making Test (Part B), Tower of London (administered at baseline only), Symbol Digit Modalities Test, Digit Span Backward, and Letter-Number Sequencing. Estrone, free estradiol, and free testosterone levels were measured at the time of the first testing, and analyses were restricted to 147 women aged 56-64 years who had recently undergone natural menopause (mean age of menopause 53 years) and were not using hormone therapy. In multiple linear regression analyses, 2 of 20 baseline associations were significant at an alpha level of 0.05. Estrone concentrations were positively associated with Tower of London performance (p = 0.02), and the ratio of free testosterone to free estradiol was positively associated with scores on the Symbol Digit Modalities Test score (p=0.04). No hormone measure was significantly predictive of 2-year change in executive functions performance. Significance levels in these exploratory analyses were unadjusted for multiple comparisons, and observed associations could be due to unique psychometric properties of these particular tasks or due to chance. Sex hormone binding globulin concentrations were unrelated to executive function scores. In recently postmenopausal women not receiving hormone therapy, serum concentrations of estrone, estradiol and testosterone, and the testosterone/estradiol ratio are not strongly associated with executive functions.
CC :	770B03C
FD :	Fonction exécutive; Postménopause; Femelle; Stéroïde; Cognition; Estradiol; Oestrogène; Ménopause; Testostérone; Mémoire de travail; Homme; Femme
FG :	Hormone ovarienne; Hormone stéroïde sexuelle; Androgène; Hormone testiculaire
ED :	Executive function; Postmenopause; Female; Steroid; Cognition; Estradiol; Estrogen; Menopause; Testosterone; Working memory; Human; Woman
EG :	Ovarian hormone; Sex steroid hormone; Androgen; Testicular hormone
SD :	Función ejecutiva; Postmenopausia; Hembra; Esteroide; Cognición; Estradiol; Estrógeno; Menopausia; Testosterona; Memoria trabajo; Hombre; Mujer
LO :	INIST-12895.354000194440000180
ID :	11-0224964

Links to Exploration step

Francis:11-0224964

Le document en format XML

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<front><div type="abstract" xml:lang="en">It is controversial to what extent endogenous gonadal hormone exposures influence executive functions in midlife women. Participants in the population-based Melbourne Women's Midlife Health Project were administered a battery of neuropsychological tests on two occasions 2 years apart. Tests of executive functions were the Trail Making Test (Part B), Tower of London (administered at baseline only), Symbol Digit Modalities Test, Digit Span Backward, and Letter-Number Sequencing. Estrone, free estradiol, and free testosterone levels were measured at the time of the first testing, and analyses were restricted to 147 women aged 56-64 years who had recently undergone natural menopause (mean age of menopause 53 years) and were not using hormone therapy. In multiple linear regression analyses, 2 of 20 baseline associations were significant at an alpha level of 0.05. Estrone concentrations were positively associated with Tower of London performance (p = 0.02), and the ratio of free testosterone to free estradiol was positively associated with scores on the Symbol Digit Modalities Test score (p=0.04). No hormone measure was significantly predictive of 2-year change in executive functions performance. Significance levels in these exploratory analyses were unadjusted for multiple comparisons, and observed associations could be due to unique psychometric properties of these particular tasks or due to chance. Sex hormone binding globulin concentrations were unrelated to executive function scores. In recently postmenopausal women not receiving hormone therapy, serum concentrations of estrone, estradiol and testosterone, and the testosterone/estradiol ratio are not strongly associated with executive functions.</div>
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<fC01 i1="01" l="ENG"><s0>It is controversial to what extent endogenous gonadal hormone exposures influence executive functions in midlife women. Participants in the population-based Melbourne Women's Midlife Health Project were administered a battery of neuropsychological tests on two occasions 2 years apart. Tests of executive functions were the Trail Making Test (Part B), Tower of London (administered at baseline only), Symbol Digit Modalities Test, Digit Span Backward, and Letter-Number Sequencing. Estrone, free estradiol, and free testosterone levels were measured at the time of the first testing, and analyses were restricted to 147 women aged 56-64 years who had recently undergone natural menopause (mean age of menopause 53 years) and were not using hormone therapy. In multiple linear regression analyses, 2 of 20 baseline associations were significant at an alpha level of 0.05. Estrone concentrations were positively associated with Tower of London performance (p = 0.02), and the ratio of free testosterone to free estradiol was positively associated with scores on the Symbol Digit Modalities Test score (p=0.04). No hormone measure was significantly predictive of 2-year change in executive functions performance. Significance levels in these exploratory analyses were unadjusted for multiple comparisons, and observed associations could be due to unique psychometric properties of these particular tasks or due to chance. Sex hormone binding globulin concentrations were unrelated to executive function scores. In recently postmenopausal women not receiving hormone therapy, serum concentrations of estrone, estradiol and testosterone, and the testosterone/estradiol ratio are not strongly associated with executive functions.</s0>
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<server><NO>FRANCIS 11-0224964 INIST</NO>
<ET>Executive functions in recently postmenopausal women: Absence of strong association with serum gonadal steroids</ET>
<AU>RYAN (Joanne); STANCZYK (Frank Z.); DENNERSTEIN (Lorraine); MACK (Wendy J.); CLARK (Margaret S.); SZOEKE (Cassandra); HENDERSON (Victor W.); MILNER (Teresa A.)</AU>
<AF>Department of Psychiatry, The University of Melbourne/Parkville, Victoria 3010/Australie (1 aut., 3 aut., 5 aut., 6 aut.); National Ageing Research Institute, The University of Melbourne/Parkville, Victoria 3010/Australie (1 aut., 3 aut.); Inserm, U888, Montpellier F-34093, France, Univ Montpellier1/Montpellier F-34000/France (1 aut.); Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California/Los Angeles, CA 90033/Etats-Unis (2 aut.); Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Los Angeles, CA 90033/Etats-Unis (4 aut.); Departments of Health Research and Policy (Epidemiology) and of Neurology and Neurological Sciences, Stanford University/Stanford, CA 94305/Etats-Unis (7 aut.); Weil Cornell Medical College/New York/Etats-Unis (1 aut.)</AF>
<DT>Publication en série; Congrès; Niveau analytique</DT>
<SO>Brain research; ISSN 0006-8993; Coden BRREAP; Pays-Bas; Da. 2011; Vol. 1379; Pp. 199-205; Bibl. 3/4 p.</SO>
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<EA>It is controversial to what extent endogenous gonadal hormone exposures influence executive functions in midlife women. Participants in the population-based Melbourne Women's Midlife Health Project were administered a battery of neuropsychological tests on two occasions 2 years apart. Tests of executive functions were the Trail Making Test (Part B), Tower of London (administered at baseline only), Symbol Digit Modalities Test, Digit Span Backward, and Letter-Number Sequencing. Estrone, free estradiol, and free testosterone levels were measured at the time of the first testing, and analyses were restricted to 147 women aged 56-64 years who had recently undergone natural menopause (mean age of menopause 53 years) and were not using hormone therapy. In multiple linear regression analyses, 2 of 20 baseline associations were significant at an alpha level of 0.05. Estrone concentrations were positively associated with Tower of London performance (p = 0.02), and the ratio of free testosterone to free estradiol was positively associated with scores on the Symbol Digit Modalities Test score (p=0.04). No hormone measure was significantly predictive of 2-year change in executive functions performance. Significance levels in these exploratory analyses were unadjusted for multiple comparisons, and observed associations could be due to unique psychometric properties of these particular tasks or due to chance. Sex hormone binding globulin concentrations were unrelated to executive function scores. In recently postmenopausal women not receiving hormone therapy, serum concentrations of estrone, estradiol and testosterone, and the testosterone/estradiol ratio are not strongly associated with executive functions.</EA>
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<FD>Fonction exécutive; Postménopause; Femelle; Stéroïde; Cognition; Estradiol; Oestrogène; Ménopause; Testostérone; Mémoire de travail; Homme; Femme</FD>
<FG>Hormone ovarienne; Hormone stéroïde sexuelle; Androgène; Hormone testiculaire</FG>
<ED>Executive function; Postmenopause; Female; Steroid; Cognition; Estradiol; Estrogen; Menopause; Testosterone; Working memory; Human; Woman</ED>
<EG>Ovarian hormone; Sex steroid hormone; Androgen; Testicular hormone</EG>
<SD>Función ejecutiva; Postmenopausia; Hembra; Esteroide; Cognición; Estradiol; Estrógeno; Menopausia; Testosterona; Memoria trabajo; Hombre; Mujer</SD>
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Executive functions in recently postmenopausal women: Absence of strong association with serum gonadal steroids

Executive functions in recently postmenopausal women: Absence of strong association with serum gonadal steroids

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