The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length
Identifieur interne : 000048 ( PascalFrancis/Corpus ); précédent : 000047; suivant : 000049The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length
Auteurs : Mark M. Iles ; D. Timothy Bishop ; John C. Taylor ; Nicholas K. Hayward ; Myriam Brossard ; Anne E. Cust ; Alison M. Dunning ; Jeffrey E. Lee ; Eric K. Moses ; Lars A. Akslen ; Per A. Andresen ; Marie-Françoise Avril ; Esther Azizi ; Giovanna Bianchi Scarra ; Kevin M. Brown ; Tadeusz Debniak ; David E. Elder ; Eitan Friedman ; Paola Ghiorzo ; Elizabeth M. Gillanders ; Alisa M. Goldstein ; Nelleke A. Gruis ; Johan Hansson ; Mark Harland ; Per Helsing ; Marko Hocevar ; Veronica Höiom ; Christian Ingvar ; Peter A. Kanetsky ; Mariateresa Landi ; Julie Lang ; G. Mark Lathrop ; Jan Lubinski ; Rona M. Mackie ; Nicholas G. Martin ; Anders Molven ; Grant W. Montgomery ; Srdjan Novakovic ; H Kan Olsson ; Susana Puig ; Joan Anton Puig-Butille ; Graham L. Radford-Smith ; Juliette Randerson-Mor ; Nienke Van Der Stoep ; Remco Van Doorn ; David C. Whiteman ; Stuart Macgregor ; Karen A. Pooley ; Sarah V. Ward ; Graham J. Mann ; Christopher I. Amos ; Paul D. P. Pharaoh ; Florence Demenais ; Matthew H. Law ; Julia A. Newton Bishop ; Jennifer H. BarrettSource :
- Journal of the National Cancer Institute [ 0027-8874 ] ; 2014.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case patients and 13933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92×10-9, two-sided) with melanoma risk.
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Format Inist (serveur)
NO : | PASCAL 15-0030914 INIST |
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ET : | The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length |
AU : | ILES (Mark M.); BISHOP (D. Timothy); TAYLOR (John C.); HAYWARD (Nicholas K.); BROSSARD (Myriam); CUST (Anne E.); DUNNING (Alison M.); LEE (Jeffrey E.); MOSES (Eric K.); AKSLEN (Lars A.); ANDRESEN (Per A.); AVRIL (Marie-Françoise); AZIZI (Esther); SCARRA (Giovanna Bianchi); BROWN (Kevin M.); DEBNIAK (Tadeusz); ELDER (David E.); FRIEDMAN (Eitan); GHIORZO (Paola); GILLANDERS (Elizabeth M.); GOLDSTEIN (Alisa M.); GRUIS (Nelleke A.); HANSSON (Johan); HARLAND (Mark); HELSING (Per); HOCEVAR (Marko); HÖIOM (Veronica); INGVAR (Christian); KANETSKY (Peter A.); LANDI (Mariateresa); LANG (Julie); LATHROP (G. Mark); LUBINSKI (Jan); MACKIE (Rona M.); MARTIN (Nicholas G.); MOLVEN (Anders); MONTGOMERY (Grant W.); NOVAKOVIC (Srdjan); OLSSON (Håkan); PUIG (Susana); PUIG-BUTILLE (Joan Anton); RADFORD-SMITH (Graham L.); RANDERSON-MOR (Juliette); VAN DER STOEP (Nienke); VAN DOORN (Remco); WHITEMAN (David C.); MACGREGOR (Stuart); POOLEY (Karen A.); WARD (Sarah V.); MANN (Graham J.); AMOS (Christopher I.); PHARAOH (Paul D. P.); DEMENAIS (Florence); LAW (Matthew H.); NEWTON BISHOP (Julia A.); BARRETT (Jennifer H.) |
AF : | Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds Cancer Research UK Centre, University of Leeds/Leeds/Royaume-Uni (1 aut., 2 aut., 3 aut., 24 aut., 43 aut., 56 aut.); Oncogenomics, QIMR Berghofer Medical Research Institute/Brisbane/Australie (4 aut.); Genetic Epidemiology, QIMR Berghofer Medical Research Institute/Brisbane/Australie (35 aut.); Inflammatory Bowel Diseases Laboratory, QIMR Berghofer Medical Research Institute/Brisbane/Australie (42 aut.); Cancer Control Group, QIMR Berghofer Medical Research Institute/Brisbane/Australie (46 aut.); Statistical Genetics, QIMR Berghofer Medical Research Institute/Brisbane/Australie (47 aut., 54 aut.); Molecular Epidemiology, QIMR Berghofer Medical Research Institute/Brisbane/Australie (37 aut.); INSERM, UMR-946, Genetic Variation and Human Diseases Unit/Paris/France (5 aut., 53 aut.); Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie/Paris/France (5 aut., 53 aut.); Cancer Epidemiology and Services Research, Sydney School of Public Health, University of Sydney/Australie (6 aut.); Department of Oncology, University of Cambridge/Cambridge/Royaume-Uni (7 aut., 52 aut.); Department of Surgical Oncology, University of Texas MD Anderson Cancer Center/Houston, TX/Etats-Unis (8 aut.); Centre for Genetic Origins of Health and Disease, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia/Crawley/Australie (9 aut., 49 aut.); Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, University of Bergen/Bergen/Norvège (10 aut.); Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen/Bergen/Norvège (36 aut.); Department of Pathology, Haukeland University Hospital/Bergen/Norvège (10 aut.); Department of Pathology, Molecular Pathology, Oslo University Hospital/Rikshospitalet, Oslo/Norvège (11 aut.); Department of Dermatology, Oslo University Hospital/Rikshospitalet, Oslo/Norvège (25 aut.); Assistance Publique-Hôpitaux de Paris, Hôpital Cochin, Service de Dermatologie, Université Paris Descartes/Paris/France (12 aut.); Department of Dermatology, Tel Hashomer, Sackler Faculty of Medicine/Tel Aviv/Israël (13 aut.); Oncogenics Unit, Tel Hashomer, Sackler Faculty of Medicine/Tel Aviv/Israël (13 aut., 18 aut.); Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine/Tel Aviv/Israël (13 aut.); Department of Internal Medicine and Medical Specialties, University of Genoa/Genoa/Italie (14 aut., 18 aut., 19 aut.); Laboratory of Genetics of Rare Hereditary Cancers, San Martino-IST Research Hospital/Genoa/Italie (14 aut., 18 aut., 19 aut.); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health/Bethesda, MD/Etats-Unis (15 aut., 21 aut., 30 aut.) |
DT : | Publication en série; Courte communication, note brève; Niveau analytique |
SO : | Journal of the National Cancer Institute; ISSN 0027-8874; Etats-Unis; Da. 2014; Vol. 106; No. 10; 267.1-267.5; Bibl. 24 ref. |
LA : | Anglais |
EA : | Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case patients and 13933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92×10-9, two-sided) with melanoma risk. |
CC : | 002B04C; 002B08A |
FD : | Mélanome malin; Facteur risque; Risque; Gène; Génétique; Association; Télomère; Longueur; Cancérologie |
FG : | Tumeur maligne; Cancer |
ED : | Malignant melanoma; Risk factor; Risk; Gene; Genetics; Association; Telomere; Length; Cancerology |
EG : | Malignant tumor; Cancer |
SD : | Melanoma maligno; Factor riesgo; Riesgo; Gen; Genética; Asociación; Telómero; Longitud; Cancerología |
LO : | INIST-3364.354000508282850210 |
ID : | 15-0030914 |
Links to Exploration step
Pascal:15-0030914Le document en format XML
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<author><name sortKey="Scarra, Giovanna Bianchi" sort="Scarra, Giovanna Bianchi" uniqKey="Scarra G" first="Giovanna Bianchi" last="Scarra">Giovanna Bianchi Scarra</name>
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<author><name sortKey="Brown, Kevin M" sort="Brown, Kevin M" uniqKey="Brown K" first="Kevin M." last="Brown">Kevin M. Brown</name>
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<author><name sortKey="Debniak, Tadeusz" sort="Debniak, Tadeusz" uniqKey="Debniak T" first="Tadeusz" last="Debniak">Tadeusz Debniak</name>
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<author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name>
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</affiliation>
<affiliation><inist:fA14 i1="23"><s1>Department of Internal Medicine and Medical Specialties, University of Genoa</s1>
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<s3>ITA</s3>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
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</affiliation>
<affiliation><inist:fA14 i1="24"><s1>Laboratory of Genetics of Rare Hereditary Cancers, San Martino-IST Research Hospital</s1>
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<sZ>14 aut.</sZ>
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<author><name sortKey="Ghiorzo, Paola" sort="Ghiorzo, Paola" uniqKey="Ghiorzo P" first="Paola" last="Ghiorzo">Paola Ghiorzo</name>
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<affiliation><inist:fA14 i1="24"><s1>Laboratory of Genetics of Rare Hereditary Cancers, San Martino-IST Research Hospital</s1>
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<author><name sortKey="Gillanders, Elizabeth M" sort="Gillanders, Elizabeth M" uniqKey="Gillanders E" first="Elizabeth M." last="Gillanders">Elizabeth M. Gillanders</name>
</author>
<author><name sortKey="Goldstein, Alisa M" sort="Goldstein, Alisa M" uniqKey="Goldstein A" first="Alisa M." last="Goldstein">Alisa M. Goldstein</name>
<affiliation><inist:fA14 i1="25"><s1>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health</s1>
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<author><name sortKey="Gruis, Nelleke A" sort="Gruis, Nelleke A" uniqKey="Gruis N" first="Nelleke A." last="Gruis">Nelleke A. Gruis</name>
</author>
<author><name sortKey="Hansson, Johan" sort="Hansson, Johan" uniqKey="Hansson J" first="Johan" last="Hansson">Johan Hansson</name>
</author>
<author><name sortKey="Harland, Mark" sort="Harland, Mark" uniqKey="Harland M" first="Mark" last="Harland">Mark Harland</name>
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<author><name sortKey="Helsing, Per" sort="Helsing, Per" uniqKey="Helsing P" first="Per" last="Helsing">Per Helsing</name>
<affiliation><inist:fA14 i1="18"><s1>Department of Dermatology, Oslo University Hospital</s1>
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</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Hocevar, Marko" sort="Hocevar, Marko" uniqKey="Hocevar M" first="Marko" last="Hocevar">Marko Hocevar</name>
</author>
<author><name sortKey="Hoiom, Veronica" sort="Hoiom, Veronica" uniqKey="Hoiom V" first="Veronica" last="Höiom">Veronica Höiom</name>
</author>
<author><name sortKey="Ingvar, Christian" sort="Ingvar, Christian" uniqKey="Ingvar C" first="Christian" last="Ingvar">Christian Ingvar</name>
</author>
<author><name sortKey="Kanetsky, Peter A" sort="Kanetsky, Peter A" uniqKey="Kanetsky P" first="Peter A." last="Kanetsky">Peter A. Kanetsky</name>
</author>
<author><name sortKey="Landi, Mariateresa" sort="Landi, Mariateresa" uniqKey="Landi M" first="Mariateresa" last="Landi">Mariateresa Landi</name>
<affiliation><inist:fA14 i1="25"><s1>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health</s1>
<s2>Bethesda, MD</s2>
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<sZ>30 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Lang, Julie" sort="Lang, Julie" uniqKey="Lang J" first="Julie" last="Lang">Julie Lang</name>
</author>
<author><name sortKey="Lathrop, G Mark" sort="Lathrop, G Mark" uniqKey="Lathrop G" first="G. Mark" last="Lathrop">G. Mark Lathrop</name>
</author>
<author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name>
</author>
<author><name sortKey="Mackie, Rona M" sort="Mackie, Rona M" uniqKey="Mackie R" first="Rona M." last="Mackie">Rona M. Mackie</name>
</author>
<author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name>
<affiliation><inist:fA14 i1="03"><s1>Genetic Epidemiology, QIMR Berghofer Medical Research Institute</s1>
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<author><name sortKey="Molven, Anders" sort="Molven, Anders" uniqKey="Molven A" first="Anders" last="Molven">Anders Molven</name>
<affiliation><inist:fA14 i1="15"><s1>Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen</s1>
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<author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name>
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<author><name sortKey="Novakovic, Srdjan" sort="Novakovic, Srdjan" uniqKey="Novakovic S" first="Srdjan" last="Novakovic">Srdjan Novakovic</name>
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<author><name sortKey="Olsson, H Kan" sort="Olsson, H Kan" uniqKey="Olsson H" first="H Kan" last="Olsson">H Kan Olsson</name>
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<author><name sortKey="Puig Butille, Joan Anton" sort="Puig Butille, Joan Anton" uniqKey="Puig Butille J" first="Joan Anton" last="Puig-Butille">Joan Anton Puig-Butille</name>
</author>
<author><name sortKey="Radford Smith, Graham L" sort="Radford Smith, Graham L" uniqKey="Radford Smith G" first="Graham L." last="Radford-Smith">Graham L. Radford-Smith</name>
<affiliation><inist:fA14 i1="04"><s1>Inflammatory Bowel Diseases Laboratory, QIMR Berghofer Medical Research Institute</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>42 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Randerson Mor, Juliette" sort="Randerson Mor, Juliette" uniqKey="Randerson Mor J" first="Juliette" last="Randerson-Mor">Juliette Randerson-Mor</name>
<affiliation><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds Cancer Research UK Centre, University of Leeds</s1>
<s2>Leeds</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>43 aut.</sZ>
<sZ>56 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Van Der Stoep, Nienke" sort="Van Der Stoep, Nienke" uniqKey="Van Der Stoep N" first="Nienke" last="Van Der Stoep">Nienke Van Der Stoep</name>
</author>
<author><name sortKey="Van Doorn, Remco" sort="Van Doorn, Remco" uniqKey="Van Doorn R" first="Remco" last="Van Doorn">Remco Van Doorn</name>
</author>
<author><name sortKey="Whiteman, David C" sort="Whiteman, David C" uniqKey="Whiteman D" first="David C." last="Whiteman">David C. Whiteman</name>
<affiliation><inist:fA14 i1="05"><s1>Cancer Control Group, QIMR Berghofer Medical Research Institute</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>46 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name>
<affiliation><inist:fA14 i1="06"><s1>Statistical Genetics, QIMR Berghofer Medical Research Institute</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>47 aut.</sZ>
<sZ>54 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Pooley, Karen A" sort="Pooley, Karen A" uniqKey="Pooley K" first="Karen A." last="Pooley">Karen A. Pooley</name>
</author>
<author><name sortKey="Ward, Sarah V" sort="Ward, Sarah V" uniqKey="Ward S" first="Sarah V." last="Ward">Sarah V. Ward</name>
<affiliation><inist:fA14 i1="13"><s1>Centre for Genetic Origins of Health and Disease, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia</s1>
<s2>Crawley</s2>
<s3>AUS</s3>
<sZ>9 aut.</sZ>
<sZ>49 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Mann, Graham J" sort="Mann, Graham J" uniqKey="Mann G" first="Graham J." last="Mann">Graham J. Mann</name>
</author>
<author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I." last="Amos">Christopher I. Amos</name>
</author>
<author><name sortKey="Pharaoh, Paul D P" sort="Pharaoh, Paul D P" uniqKey="Pharaoh P" first="Paul D. P." last="Pharaoh">Paul D. P. Pharaoh</name>
<affiliation><inist:fA14 i1="11"><s1>Department of Oncology, University of Cambridge</s1>
<s2>Cambridge</s2>
<s3>GBR</s3>
<sZ>7 aut.</sZ>
<sZ>52 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Demenais, Florence" sort="Demenais, Florence" uniqKey="Demenais F" first="Florence" last="Demenais">Florence Demenais</name>
<affiliation><inist:fA14 i1="08"><s1>INSERM, UMR-946, Genetic Variation and Human Diseases Unit</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>53 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="09"><s1>Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>53 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Law, Matthew H" sort="Law, Matthew H" uniqKey="Law M" first="Matthew H." last="Law">Matthew H. Law</name>
<affiliation><inist:fA14 i1="06"><s1>Statistical Genetics, QIMR Berghofer Medical Research Institute</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>47 aut.</sZ>
<sZ>54 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Newton Bishop, Julia A" sort="Newton Bishop, Julia A" uniqKey="Newton Bishop J" first="Julia A." last="Newton Bishop">Julia A. Newton Bishop</name>
</author>
<author><name sortKey="Barrett, Jennifer H" sort="Barrett, Jennifer H" uniqKey="Barrett J" first="Jennifer H." last="Barrett">Jennifer H. Barrett</name>
<affiliation><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds Cancer Research UK Centre, University of Leeds</s1>
<s2>Leeds</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>43 aut.</sZ>
<sZ>56 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">15-0030914</idno>
<date when="2014">2014</date>
<idno type="stanalyst">PASCAL 15-0030914 INIST</idno>
<idno type="RBID">Pascal:15-0030914</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000048</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length</title>
<author><name sortKey="Iles, Mark M" sort="Iles, Mark M" uniqKey="Iles M" first="Mark M." last="Iles">Mark M. Iles</name>
<affiliation><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds Cancer Research UK Centre, University of Leeds</s1>
<s2>Leeds</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>43 aut.</sZ>
<sZ>56 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Bishop, D Timothy" sort="Bishop, D Timothy" uniqKey="Bishop D" first="D. Timothy" last="Bishop">D. Timothy Bishop</name>
<affiliation><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds Cancer Research UK Centre, University of Leeds</s1>
<s2>Leeds</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>43 aut.</sZ>
<sZ>56 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Taylor, John C" sort="Taylor, John C" uniqKey="Taylor J" first="John C." last="Taylor">John C. Taylor</name>
<affiliation><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds Cancer Research UK Centre, University of Leeds</s1>
<s2>Leeds</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>43 aut.</sZ>
<sZ>56 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Hayward, Nicholas K" sort="Hayward, Nicholas K" uniqKey="Hayward N" first="Nicholas K." last="Hayward">Nicholas K. Hayward</name>
<affiliation><inist:fA14 i1="02"><s1>Oncogenomics, QIMR Berghofer Medical Research Institute</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Brossard, Myriam" sort="Brossard, Myriam" uniqKey="Brossard M" first="Myriam" last="Brossard">Myriam Brossard</name>
<affiliation><inist:fA14 i1="08"><s1>INSERM, UMR-946, Genetic Variation and Human Diseases Unit</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>53 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="09"><s1>Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>53 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Cust, Anne E" sort="Cust, Anne E" uniqKey="Cust A" first="Anne E." last="Cust">Anne E. Cust</name>
<affiliation><inist:fA14 i1="10"><s1>Cancer Epidemiology and Services Research, Sydney School of Public Health, University of Sydney</s1>
<s3>AUS</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name>
<affiliation><inist:fA14 i1="11"><s1>Department of Oncology, University of Cambridge</s1>
<s2>Cambridge</s2>
<s3>GBR</s3>
<sZ>7 aut.</sZ>
<sZ>52 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Lee, Jeffrey E" sort="Lee, Jeffrey E" uniqKey="Lee J" first="Jeffrey E." last="Lee">Jeffrey E. Lee</name>
<affiliation><inist:fA14 i1="12"><s1>Department of Surgical Oncology, University of Texas MD Anderson Cancer Center</s1>
<s2>Houston, TX</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Moses, Eric K" sort="Moses, Eric K" uniqKey="Moses E" first="Eric K." last="Moses">Eric K. Moses</name>
<affiliation><inist:fA14 i1="13"><s1>Centre for Genetic Origins of Health and Disease, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia</s1>
<s2>Crawley</s2>
<s3>AUS</s3>
<sZ>9 aut.</sZ>
<sZ>49 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Akslen, Lars A" sort="Akslen, Lars A" uniqKey="Akslen L" first="Lars A." last="Akslen">Lars A. Akslen</name>
<affiliation><inist:fA14 i1="14"><s1>Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, University of Bergen</s1>
<s2>Bergen</s2>
<s3>NOR</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="16"><s1>Department of Pathology, Haukeland University Hospital</s1>
<s2>Bergen</s2>
<s3>NOR</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Andresen, Per A" sort="Andresen, Per A" uniqKey="Andresen P" first="Per A." last="Andresen">Per A. Andresen</name>
<affiliation><inist:fA14 i1="17"><s1>Department of Pathology, Molecular Pathology, Oslo University Hospital</s1>
<s2>Rikshospitalet, Oslo</s2>
<s3>NOR</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Avril, Marie Francoise" sort="Avril, Marie Francoise" uniqKey="Avril M" first="Marie-Françoise" last="Avril">Marie-Françoise Avril</name>
<affiliation><inist:fA14 i1="19"><s1>Assistance Publique-Hôpitaux de Paris, Hôpital Cochin, Service de Dermatologie, Université Paris Descartes</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Azizi, Esther" sort="Azizi, Esther" uniqKey="Azizi E" first="Esther" last="Azizi">Esther Azizi</name>
<affiliation><inist:fA14 i1="20"><s1>Department of Dermatology, Tel Hashomer, Sackler Faculty of Medicine</s1>
<s2>Tel Aviv</s2>
<s3>ISR</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="21"><s1>Oncogenics Unit, Tel Hashomer, Sackler Faculty of Medicine</s1>
<s2>Tel Aviv</s2>
<s3>ISR</s3>
<sZ>13 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="22"><s1>Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine</s1>
<s2>Tel Aviv</s2>
<s3>ISR</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Scarra, Giovanna Bianchi" sort="Scarra, Giovanna Bianchi" uniqKey="Scarra G" first="Giovanna Bianchi" last="Scarra">Giovanna Bianchi Scarra</name>
<affiliation><inist:fA14 i1="23"><s1>Department of Internal Medicine and Medical Specialties, University of Genoa</s1>
<s2>Genoa</s2>
<s3>ITA</s3>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="24"><s1>Laboratory of Genetics of Rare Hereditary Cancers, San Martino-IST Research Hospital</s1>
<s2>Genoa</s2>
<s3>ITA</s3>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Brown, Kevin M" sort="Brown, Kevin M" uniqKey="Brown K" first="Kevin M." last="Brown">Kevin M. Brown</name>
<affiliation><inist:fA14 i1="25"><s1>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health</s1>
<s2>Bethesda, MD</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Debniak, Tadeusz" sort="Debniak, Tadeusz" uniqKey="Debniak T" first="Tadeusz" last="Debniak">Tadeusz Debniak</name>
</author>
<author><name sortKey="Elder, David E" sort="Elder, David E" uniqKey="Elder D" first="David E." last="Elder">David E. Elder</name>
</author>
<author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name>
<affiliation><inist:fA14 i1="21"><s1>Oncogenics Unit, Tel Hashomer, Sackler Faculty of Medicine</s1>
<s2>Tel Aviv</s2>
<s3>ISR</s3>
<sZ>13 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="23"><s1>Department of Internal Medicine and Medical Specialties, University of Genoa</s1>
<s2>Genoa</s2>
<s3>ITA</s3>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="24"><s1>Laboratory of Genetics of Rare Hereditary Cancers, San Martino-IST Research Hospital</s1>
<s2>Genoa</s2>
<s3>ITA</s3>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Ghiorzo, Paola" sort="Ghiorzo, Paola" uniqKey="Ghiorzo P" first="Paola" last="Ghiorzo">Paola Ghiorzo</name>
<affiliation><inist:fA14 i1="23"><s1>Department of Internal Medicine and Medical Specialties, University of Genoa</s1>
<s2>Genoa</s2>
<s3>ITA</s3>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="24"><s1>Laboratory of Genetics of Rare Hereditary Cancers, San Martino-IST Research Hospital</s1>
<s2>Genoa</s2>
<s3>ITA</s3>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Gillanders, Elizabeth M" sort="Gillanders, Elizabeth M" uniqKey="Gillanders E" first="Elizabeth M." last="Gillanders">Elizabeth M. Gillanders</name>
</author>
<author><name sortKey="Goldstein, Alisa M" sort="Goldstein, Alisa M" uniqKey="Goldstein A" first="Alisa M." last="Goldstein">Alisa M. Goldstein</name>
<affiliation><inist:fA14 i1="25"><s1>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health</s1>
<s2>Bethesda, MD</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Gruis, Nelleke A" sort="Gruis, Nelleke A" uniqKey="Gruis N" first="Nelleke A." last="Gruis">Nelleke A. Gruis</name>
</author>
<author><name sortKey="Hansson, Johan" sort="Hansson, Johan" uniqKey="Hansson J" first="Johan" last="Hansson">Johan Hansson</name>
</author>
<author><name sortKey="Harland, Mark" sort="Harland, Mark" uniqKey="Harland M" first="Mark" last="Harland">Mark Harland</name>
<affiliation><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds Cancer Research UK Centre, University of Leeds</s1>
<s2>Leeds</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>43 aut.</sZ>
<sZ>56 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Helsing, Per" sort="Helsing, Per" uniqKey="Helsing P" first="Per" last="Helsing">Per Helsing</name>
<affiliation><inist:fA14 i1="18"><s1>Department of Dermatology, Oslo University Hospital</s1>
<s2>Rikshospitalet, Oslo</s2>
<s3>NOR</s3>
<sZ>25 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Hocevar, Marko" sort="Hocevar, Marko" uniqKey="Hocevar M" first="Marko" last="Hocevar">Marko Hocevar</name>
</author>
<author><name sortKey="Hoiom, Veronica" sort="Hoiom, Veronica" uniqKey="Hoiom V" first="Veronica" last="Höiom">Veronica Höiom</name>
</author>
<author><name sortKey="Ingvar, Christian" sort="Ingvar, Christian" uniqKey="Ingvar C" first="Christian" last="Ingvar">Christian Ingvar</name>
</author>
<author><name sortKey="Kanetsky, Peter A" sort="Kanetsky, Peter A" uniqKey="Kanetsky P" first="Peter A." last="Kanetsky">Peter A. Kanetsky</name>
</author>
<author><name sortKey="Landi, Mariateresa" sort="Landi, Mariateresa" uniqKey="Landi M" first="Mariateresa" last="Landi">Mariateresa Landi</name>
<affiliation><inist:fA14 i1="25"><s1>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health</s1>
<s2>Bethesda, MD</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Lang, Julie" sort="Lang, Julie" uniqKey="Lang J" first="Julie" last="Lang">Julie Lang</name>
</author>
<author><name sortKey="Lathrop, G Mark" sort="Lathrop, G Mark" uniqKey="Lathrop G" first="G. Mark" last="Lathrop">G. Mark Lathrop</name>
</author>
<author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name>
</author>
<author><name sortKey="Mackie, Rona M" sort="Mackie, Rona M" uniqKey="Mackie R" first="Rona M." last="Mackie">Rona M. Mackie</name>
</author>
<author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name>
<affiliation><inist:fA14 i1="03"><s1>Genetic Epidemiology, QIMR Berghofer Medical Research Institute</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>35 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Molven, Anders" sort="Molven, Anders" uniqKey="Molven A" first="Anders" last="Molven">Anders Molven</name>
<affiliation><inist:fA14 i1="15"><s1>Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen</s1>
<s2>Bergen</s2>
<s3>NOR</s3>
<sZ>36 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name>
<affiliation><inist:fA14 i1="07"><s1>Molecular Epidemiology, QIMR Berghofer Medical Research Institute</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>37 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Novakovic, Srdjan" sort="Novakovic, Srdjan" uniqKey="Novakovic S" first="Srdjan" last="Novakovic">Srdjan Novakovic</name>
</author>
<author><name sortKey="Olsson, H Kan" sort="Olsson, H Kan" uniqKey="Olsson H" first="H Kan" last="Olsson">H Kan Olsson</name>
</author>
<author><name sortKey="Puig, Susana" sort="Puig, Susana" uniqKey="Puig S" first="Susana" last="Puig">Susana Puig</name>
</author>
<author><name sortKey="Puig Butille, Joan Anton" sort="Puig Butille, Joan Anton" uniqKey="Puig Butille J" first="Joan Anton" last="Puig-Butille">Joan Anton Puig-Butille</name>
</author>
<author><name sortKey="Radford Smith, Graham L" sort="Radford Smith, Graham L" uniqKey="Radford Smith G" first="Graham L." last="Radford-Smith">Graham L. Radford-Smith</name>
<affiliation><inist:fA14 i1="04"><s1>Inflammatory Bowel Diseases Laboratory, QIMR Berghofer Medical Research Institute</s1>
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<sZ>42 aut.</sZ>
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<author><name sortKey="Randerson Mor, Juliette" sort="Randerson Mor, Juliette" uniqKey="Randerson Mor J" first="Juliette" last="Randerson-Mor">Juliette Randerson-Mor</name>
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<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>43 aut.</sZ>
<sZ>56 aut.</sZ>
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<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>47 aut.</sZ>
<sZ>54 aut.</sZ>
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<author><name sortKey="Pooley, Karen A" sort="Pooley, Karen A" uniqKey="Pooley K" first="Karen A." last="Pooley">Karen A. Pooley</name>
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<affiliation><inist:fA14 i1="13"><s1>Centre for Genetic Origins of Health and Disease, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia</s1>
<s2>Crawley</s2>
<s3>AUS</s3>
<sZ>9 aut.</sZ>
<sZ>49 aut.</sZ>
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</author>
<author><name sortKey="Pharaoh, Paul D P" sort="Pharaoh, Paul D P" uniqKey="Pharaoh P" first="Paul D. P." last="Pharaoh">Paul D. P. Pharaoh</name>
<affiliation><inist:fA14 i1="11"><s1>Department of Oncology, University of Cambridge</s1>
<s2>Cambridge</s2>
<s3>GBR</s3>
<sZ>7 aut.</sZ>
<sZ>52 aut.</sZ>
</inist:fA14>
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<author><name sortKey="Demenais, Florence" sort="Demenais, Florence" uniqKey="Demenais F" first="Florence" last="Demenais">Florence Demenais</name>
<affiliation><inist:fA14 i1="08"><s1>INSERM, UMR-946, Genetic Variation and Human Diseases Unit</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>53 aut.</sZ>
</inist:fA14>
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<affiliation><inist:fA14 i1="09"><s1>Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>53 aut.</sZ>
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<author><name sortKey="Law, Matthew H" sort="Law, Matthew H" uniqKey="Law M" first="Matthew H." last="Law">Matthew H. Law</name>
<affiliation><inist:fA14 i1="06"><s1>Statistical Genetics, QIMR Berghofer Medical Research Institute</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>47 aut.</sZ>
<sZ>54 aut.</sZ>
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<author><name sortKey="Newton Bishop, Julia A" sort="Newton Bishop, Julia A" uniqKey="Newton Bishop J" first="Julia A." last="Newton Bishop">Julia A. Newton Bishop</name>
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<author><name sortKey="Barrett, Jennifer H" sort="Barrett, Jennifer H" uniqKey="Barrett J" first="Jennifer H." last="Barrett">Jennifer H. Barrett</name>
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<s2>Leeds</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>43 aut.</sZ>
<sZ>56 aut.</sZ>
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<series><title level="j" type="main">Journal of the National Cancer Institute</title>
<title level="j" type="abbreviated">J. Natl. Cancer Inst.</title>
<idno type="ISSN">0027-8874</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of the National Cancer Institute</title>
<title level="j" type="abbreviated">J. Natl. Cancer Inst.</title>
<idno type="ISSN">0027-8874</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Association</term>
<term>Cancerology</term>
<term>Gene</term>
<term>Genetics</term>
<term>Length</term>
<term>Malignant melanoma</term>
<term>Risk</term>
<term>Risk factor</term>
<term>Telomere</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Mélanome malin</term>
<term>Facteur risque</term>
<term>Risque</term>
<term>Gène</term>
<term>Génétique</term>
<term>Association</term>
<term>Télomère</term>
<term>Longueur</term>
<term>Cancérologie</term>
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<front><div type="abstract" xml:lang="en">Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case patients and 13933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92×10<sup>-9</sup>
, two-sided) with melanoma risk.</div>
</front>
</TEI>
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<fA08 i1="01" i2="1" l="ENG"><s1>The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length</s1>
</fA08>
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<fA11 i1="23" i2="1"><s1>HANSSON (Johan)</s1>
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<fA11 i1="24" i2="1"><s1>HARLAND (Mark)</s1>
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<fA11 i1="25" i2="1"><s1>HELSING (Per)</s1>
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<fA11 i1="26" i2="1"><s1>HOCEVAR (Marko)</s1>
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<fA11 i1="27" i2="1"><s1>HÖIOM (Veronica)</s1>
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<fA11 i1="48" i2="1"><s1>POOLEY (Karen A.)</s1>
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<fA11 i1="49" i2="1"><s1>WARD (Sarah V.)</s1>
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<fA11 i1="50" i2="1"><s1>MANN (Graham J.)</s1>
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<fA11 i1="51" i2="1"><s1>AMOS (Christopher I.)</s1>
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<fA11 i1="52" i2="1"><s1>PHARAOH (Paul D. P.)</s1>
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<fA11 i1="53" i2="1"><s1>DEMENAIS (Florence)</s1>
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<sZ>2 aut.</sZ>
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<sZ>24 aut.</sZ>
<sZ>43 aut.</sZ>
<sZ>56 aut.</sZ>
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<fA14 i1="02"><s1>Oncogenomics, QIMR Berghofer Medical Research Institute</s1>
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<fA14 i1="03"><s1>Genetic Epidemiology, QIMR Berghofer Medical Research Institute</s1>
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<fA14 i1="04"><s1>Inflammatory Bowel Diseases Laboratory, QIMR Berghofer Medical Research Institute</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>42 aut.</sZ>
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<fA14 i1="05"><s1>Cancer Control Group, QIMR Berghofer Medical Research Institute</s1>
<s2>Brisbane</s2>
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<fA14 i1="06"><s1>Statistical Genetics, QIMR Berghofer Medical Research Institute</s1>
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<s3>AUS</s3>
<sZ>47 aut.</sZ>
<sZ>54 aut.</sZ>
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<fA14 i1="07"><s1>Molecular Epidemiology, QIMR Berghofer Medical Research Institute</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>37 aut.</sZ>
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<fA14 i1="08"><s1>INSERM, UMR-946, Genetic Variation and Human Diseases Unit</s1>
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<sZ>5 aut.</sZ>
<sZ>53 aut.</sZ>
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<fA14 i1="09"><s1>Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>53 aut.</sZ>
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<fA14 i1="10"><s1>Cancer Epidemiology and Services Research, Sydney School of Public Health, University of Sydney</s1>
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<sZ>6 aut.</sZ>
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<fA14 i1="11"><s1>Department of Oncology, University of Cambridge</s1>
<s2>Cambridge</s2>
<s3>GBR</s3>
<sZ>7 aut.</sZ>
<sZ>52 aut.</sZ>
</fA14>
<fA14 i1="12"><s1>Department of Surgical Oncology, University of Texas MD Anderson Cancer Center</s1>
<s2>Houston, TX</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="13"><s1>Centre for Genetic Origins of Health and Disease, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia</s1>
<s2>Crawley</s2>
<s3>AUS</s3>
<sZ>9 aut.</sZ>
<sZ>49 aut.</sZ>
</fA14>
<fA14 i1="14"><s1>Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, University of Bergen</s1>
<s2>Bergen</s2>
<s3>NOR</s3>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="15"><s1>Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen</s1>
<s2>Bergen</s2>
<s3>NOR</s3>
<sZ>36 aut.</sZ>
</fA14>
<fA14 i1="16"><s1>Department of Pathology, Haukeland University Hospital</s1>
<s2>Bergen</s2>
<s3>NOR</s3>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="17"><s1>Department of Pathology, Molecular Pathology, Oslo University Hospital</s1>
<s2>Rikshospitalet, Oslo</s2>
<s3>NOR</s3>
<sZ>11 aut.</sZ>
</fA14>
<fA14 i1="18"><s1>Department of Dermatology, Oslo University Hospital</s1>
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<s3>NOR</s3>
<sZ>25 aut.</sZ>
</fA14>
<fA14 i1="19"><s1>Assistance Publique-Hôpitaux de Paris, Hôpital Cochin, Service de Dermatologie, Université Paris Descartes</s1>
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<s3>FRA</s3>
<sZ>12 aut.</sZ>
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<fA14 i1="20"><s1>Department of Dermatology, Tel Hashomer, Sackler Faculty of Medicine</s1>
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<sZ>13 aut.</sZ>
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<fA14 i1="21"><s1>Oncogenics Unit, Tel Hashomer, Sackler Faculty of Medicine</s1>
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<s3>ISR</s3>
<sZ>13 aut.</sZ>
<sZ>18 aut.</sZ>
</fA14>
<fA14 i1="22"><s1>Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine</s1>
<s2>Tel Aviv</s2>
<s3>ISR</s3>
<sZ>13 aut.</sZ>
</fA14>
<fA14 i1="23"><s1>Department of Internal Medicine and Medical Specialties, University of Genoa</s1>
<s2>Genoa</s2>
<s3>ITA</s3>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
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<fA14 i1="24"><s1>Laboratory of Genetics of Rare Hereditary Cancers, San Martino-IST Research Hospital</s1>
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<s3>ITA</s3>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
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<sZ>15 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>30 aut.</sZ>
</fA14>
<fA17 i1="01" i2="1"><s1>IBD investigators, AMFS Investigators, QMEGA and QTWIN Investigators, SDH Study Group, GenoMEL Consortium</s1>
<s3>INC</s3>
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<fA21><s1>2014</s1>
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<fC03 i1="04" i2="X" l="SPA"><s0>Gen</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Génétique</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Genetics</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Genética</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Association</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Association</s0>
<s5>08</s5>
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<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Télomère</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Telomere</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Telómero</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Longueur</s0>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Length</s0>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Longitud</s0>
<s5>11</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Cancérologie</s0>
<s5>12</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Cancerology</s0>
<s5>12</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Cancerología</s0>
<s5>12</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Tumeur maligne</s0>
<s2>NM</s2>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Malignant tumor</s0>
<s2>NM</s2>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Tumor maligno</s0>
<s2>NM</s2>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Cancer</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Cancer</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Cáncer</s0>
<s2>NM</s2>
</fC07>
<fN21><s1>047</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
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<server><NO>PASCAL 15-0030914 INIST</NO>
<ET>The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length</ET>
<AU>ILES (Mark M.); BISHOP (D. Timothy); TAYLOR (John C.); HAYWARD (Nicholas K.); BROSSARD (Myriam); CUST (Anne E.); DUNNING (Alison M.); LEE (Jeffrey E.); MOSES (Eric K.); AKSLEN (Lars A.); ANDRESEN (Per A.); AVRIL (Marie-Françoise); AZIZI (Esther); SCARRA (Giovanna Bianchi); BROWN (Kevin M.); DEBNIAK (Tadeusz); ELDER (David E.); FRIEDMAN (Eitan); GHIORZO (Paola); GILLANDERS (Elizabeth M.); GOLDSTEIN (Alisa M.); GRUIS (Nelleke A.); HANSSON (Johan); HARLAND (Mark); HELSING (Per); HOCEVAR (Marko); HÖIOM (Veronica); INGVAR (Christian); KANETSKY (Peter A.); LANDI (Mariateresa); LANG (Julie); LATHROP (G. Mark); LUBINSKI (Jan); MACKIE (Rona M.); MARTIN (Nicholas G.); MOLVEN (Anders); MONTGOMERY (Grant W.); NOVAKOVIC (Srdjan); OLSSON (Håkan); PUIG (Susana); PUIG-BUTILLE (Joan Anton); RADFORD-SMITH (Graham L.); RANDERSON-MOR (Juliette); VAN DER STOEP (Nienke); VAN DOORN (Remco); WHITEMAN (David C.); MACGREGOR (Stuart); POOLEY (Karen A.); WARD (Sarah V.); MANN (Graham J.); AMOS (Christopher I.); PHARAOH (Paul D. P.); DEMENAIS (Florence); LAW (Matthew H.); NEWTON BISHOP (Julia A.); BARRETT (Jennifer H.)</AU>
<AF>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds Cancer Research UK Centre, University of Leeds/Leeds/Royaume-Uni (1 aut., 2 aut., 3 aut., 24 aut., 43 aut., 56 aut.); Oncogenomics, QIMR Berghofer Medical Research Institute/Brisbane/Australie (4 aut.); Genetic Epidemiology, QIMR Berghofer Medical Research Institute/Brisbane/Australie (35 aut.); Inflammatory Bowel Diseases Laboratory, QIMR Berghofer Medical Research Institute/Brisbane/Australie (42 aut.); Cancer Control Group, QIMR Berghofer Medical Research Institute/Brisbane/Australie (46 aut.); Statistical Genetics, QIMR Berghofer Medical Research Institute/Brisbane/Australie (47 aut., 54 aut.); Molecular Epidemiology, QIMR Berghofer Medical Research Institute/Brisbane/Australie (37 aut.); INSERM, UMR-946, Genetic Variation and Human Diseases Unit/Paris/France (5 aut., 53 aut.); Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie/Paris/France (5 aut., 53 aut.); Cancer Epidemiology and Services Research, Sydney School of Public Health, University of Sydney/Australie (6 aut.); Department of Oncology, University of Cambridge/Cambridge/Royaume-Uni (7 aut., 52 aut.); Department of Surgical Oncology, University of Texas MD Anderson Cancer Center/Houston, TX/Etats-Unis (8 aut.); Centre for Genetic Origins of Health and Disease, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia/Crawley/Australie (9 aut., 49 aut.); Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, University of Bergen/Bergen/Norvège (10 aut.); Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen/Bergen/Norvège (36 aut.); Department of Pathology, Haukeland University Hospital/Bergen/Norvège (10 aut.); Department of Pathology, Molecular Pathology, Oslo University Hospital/Rikshospitalet, Oslo/Norvège (11 aut.); Department of Dermatology, Oslo University Hospital/Rikshospitalet, Oslo/Norvège (25 aut.); Assistance Publique-Hôpitaux de Paris, Hôpital Cochin, Service de Dermatologie, Université Paris Descartes/Paris/France (12 aut.); Department of Dermatology, Tel Hashomer, Sackler Faculty of Medicine/Tel Aviv/Israël (13 aut.); Oncogenics Unit, Tel Hashomer, Sackler Faculty of Medicine/Tel Aviv/Israël (13 aut., 18 aut.); Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine/Tel Aviv/Israël (13 aut.); Department of Internal Medicine and Medical Specialties, University of Genoa/Genoa/Italie (14 aut., 18 aut., 19 aut.); Laboratory of Genetics of Rare Hereditary Cancers, San Martino-IST Research Hospital/Genoa/Italie (14 aut., 18 aut., 19 aut.); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health/Bethesda, MD/Etats-Unis (15 aut., 21 aut., 30 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Journal of the National Cancer Institute; ISSN 0027-8874; Etats-Unis; Da. 2014; Vol. 106; No. 10; 267.1-267.5; Bibl. 24 ref.</SO>
<LA>Anglais</LA>
<EA>Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case patients and 13933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92×10<sup>-9</sup>
, two-sided) with melanoma risk.</EA>
<CC>002B04C; 002B08A</CC>
<FD>Mélanome malin; Facteur risque; Risque; Gène; Génétique; Association; Télomère; Longueur; Cancérologie</FD>
<FG>Tumeur maligne; Cancer</FG>
<ED>Malignant melanoma; Risk factor; Risk; Gene; Genetics; Association; Telomere; Length; Cancerology</ED>
<EG>Malignant tumor; Cancer</EG>
<SD>Melanoma maligno; Factor riesgo; Riesgo; Gen; Genética; Asociación; Telómero; Longitud; Cancerología</SD>
<LO>INIST-3364.354000508282850210</LO>
<ID>15-0030914</ID>
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