Modulation of DNA methylation states and infant immune system by dietary supplementation with ω-3 PUFA during pregnancy in an intervention study
Identifieur interne : 000782 ( PascalFrancis/Checkpoint ); précédent : 000781; suivant : 000783Modulation of DNA methylation states and infant immune system by dietary supplementation with ω-3 PUFA during pregnancy in an intervention study
Auteurs : Ho-Sun Lee [France] ; Albino Barraza-Villarreal [Mexique] ; Hector Hernandez-Vargas [France] ; Peter D. Sly [Australie] ; Carine Biessy [France] ; Usha Ramakrishnan [États-Unis] ; Isabelle Romieu [France, Mexique] ; Zdenko Herceg [France]Source :
- The American journal of clinical nutrition [ 0002-9165 ] ; 2013.
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- topic : Nutrition.
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Abstract
Background: Early-life exposures to tobacco smoke and some dietary factors have been identified to induce epigenetic changes in genes involved in allergy and asthma development. Omega-3 (n-3) polyunsaturated fatty acid (PUFA) intake during pregnancy could modulate key cytokines and T helper (Th) cell maturation; however, little is known about the mechanism by which ω-3 PUFA could have a beneficial effect in preventing inflammatory disorders. Objective: We sought to test whether prenatal dietary supplementation with ω-3 PUFA during pregnancy may modulate epigenetic states in the infant immune system. Design: This study was based on a randomized intervention trial conducted in Mexican pregnant women supplemented daily with 400 mg docosahexaenoic acid (DHA) or a placebo from 18 to 22 wk of gestation to parturition. We applied quantitative profiling of DNA methylation states in Thl, Th2, Th17, and regulatory T-relevant genes as well as LINE1 repetitive elements of cord blood mononuclear cells (n = 261). Results: No significant difference in promoter methylation levels was shown between ω-3 PUFA-supplemented and control groups for the genes analyzed; however, ω-3 PUFA supplementation was associated with changes in methylation levels in LINE1 repetitive elements (P = 0.03) in infants of mothers who smoked during pregnancy. Furthermore, an association between the promoter methylation levels of IFNγ and IL13 was modulated by ω-3 PUFA supplementation (P = 0.06). Conclusions: Our results indicate that maternal supplementation with ω-3 PUFA during pregnancy may modulate global methylation levels and the Th1/Th2 balance in infants. Therefore, the epigenetic mechanisms could provide attractive targets for prenatal modulation and prevention of inflammatory disorders and potentially other related diseases in childhood and adulthood.
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type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Barraza Villarreal, Albino" sort="Barraza Villarreal, Albino" uniqKey="Barraza Villarreal A" first="Albino" last="Barraza-Villarreal">Albino Barraza-Villarreal</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Instituto Nacional de Salud Pública, Centro de Investigaciones en Salud Poblacional, Cuernavaca</s1><s2>Morelos</s2><s3>MEX</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Mexique</country><wicri:noRegion>Morelos</wicri:noRegion></affiliation></author><author><name sortKey="Hernandez Vargas, Hector" sort="Hernandez Vargas, Hector" uniqKey="Hernandez Vargas H" first="Hector" last="Hernandez-Vargas">Hector Hernandez-Vargas</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>International Agency for Research on Cancer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Sly, Peter D" sort="Sly, Peter D" uniqKey="Sly P" first="Peter D." last="Sly">Peter D. Sly</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Queensland Children's Medical Research Institute, Royal Children's Hospital</s1><s2>Herston, Queensland</s2><s3>AUS</s3><sZ>4 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Herston, Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Biessy, Carine" sort="Biessy, Carine" uniqKey="Biessy C" first="Carine" last="Biessy">Carine Biessy</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>International Agency for Research on Cancer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Ramakrishnan, Usha" sort="Ramakrishnan, Usha" uniqKey="Ramakrishnan U" first="Usha" last="Ramakrishnan">Usha Ramakrishnan</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Nutrition and Health Sciences and Hubert Department of Global Health, Rollins School of Public Health, Emory University</s1><s2>Atlanta, GA</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Atlanta, GA</wicri:noRegion></affiliation></author><author><name sortKey="Romieu, Isabelle" sort="Romieu, Isabelle" uniqKey="Romieu I" first="Isabelle" last="Romieu">Isabelle Romieu</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>International Agency for Research on Cancer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Instituto Nacional de Salud Pública, Centro de Investigaciones en Salud Poblacional, Cuernavaca</s1><s2>Morelos</s2><s3>MEX</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Mexique</country><wicri:noRegion>Morelos</wicri:noRegion></affiliation></author><author><name sortKey="Herceg, Zdenko" sort="Herceg, Zdenko" uniqKey="Herceg Z" first="Zdenko" last="Herceg">Zdenko Herceg</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>International Agency for Research on Cancer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">The American journal of clinical nutrition</title><title level="j" type="abbreviated">Am. j. clin. nutr.</title><idno type="ISSN">0002-9165</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The American journal of clinical nutrition</title><title level="j" type="abbreviated">Am. j. clin. nutr.</title><idno type="ISSN">0002-9165</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>DNA</term><term>Immune system</term><term>Infant</term><term>Methylation</term><term>Nutrition</term><term>Pregnancy</term><term>Supplementation</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>DNA</term><term>Méthylation</term><term>Système immunitaire</term><term>Supplémentation</term><term>Gestation</term><term>Nutrition</term><term>Nourrisson</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Nutrition</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Early-life exposures to tobacco smoke and some dietary factors have been identified to induce epigenetic changes in genes involved in allergy and asthma development. Omega-3 (n-3) polyunsaturated fatty acid (PUFA) intake during pregnancy could modulate key cytokines and T helper (Th) cell maturation; however, little is known about the mechanism by which ω-3 PUFA could have a beneficial effect in preventing inflammatory disorders. Objective: We sought to test whether prenatal dietary supplementation with ω-3 PUFA during pregnancy may modulate epigenetic states in the infant immune system. Design: This study was based on a randomized intervention trial conducted in Mexican pregnant women supplemented daily with 400 mg docosahexaenoic acid (DHA) or a placebo from 18 to 22 wk of gestation to parturition. We applied quantitative profiling of DNA methylation states in Thl, Th2, Th17, and regulatory T-relevant genes as well as LINE1 repetitive elements of cord blood mononuclear cells (n = 261). Results: No significant difference in promoter methylation levels was shown between ω-3 PUFA-supplemented and control groups for the genes analyzed; however, ω-3 PUFA supplementation was associated with changes in methylation levels in LINE1 repetitive elements (P = 0.03) in infants of mothers who smoked during pregnancy. Furthermore, an association between the promoter methylation levels of IFNγ and IL13 was modulated by ω-3 PUFA supplementation (P = 0.06). Conclusions: Our results indicate that maternal supplementation with ω-3 PUFA during pregnancy may modulate global methylation levels and the Th1/Th2 balance in infants. Therefore, the epigenetic mechanisms could provide attractive targets for prenatal modulation and prevention of inflammatory disorders and potentially other related diseases in childhood and adulthood.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0002-9165</s0></fA01><fA02 i1="01"><s0>AJCNAC</s0></fA02><fA03 i2="1"><s0>Am. j. clin. nutr.</s0></fA03><fA05><s2>98</s2></fA05><fA06><s2>2</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Modulation of DNA methylation states and infant immune system by dietary supplementation with ω-3 PUFA during pregnancy in an intervention study</s1></fA08><fA11 i1="01" i2="1"><s1>LEE (Ho-Sun)</s1></fA11><fA11 i1="02" i2="1"><s1>BARRAZA-VILLARREAL (Albino)</s1></fA11><fA11 i1="03" i2="1"><s1>HERNANDEZ-VARGAS (Hector)</s1></fA11><fA11 i1="04" i2="1"><s1>SLY (Peter D.)</s1></fA11><fA11 i1="05" i2="1"><s1>BIESSY (Carine)</s1></fA11><fA11 i1="06" i2="1"><s1>RAMAKRISHNAN (Usha)</s1></fA11><fA11 i1="07" i2="1"><s1>ROMIEU (Isabelle)</s1></fA11><fA11 i1="08" i2="1"><s1>HERCEG (Zdenko)</s1></fA11><fA14 i1="01"><s1>International Agency for Research on Cancer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></fA14><fA14 i1="02"><s1>Instituto Nacional de Salud Pública, Centro de Investigaciones en Salud Poblacional, Cuernavaca</s1><s2>Morelos</s2><s3>MEX</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="03"><s1>Queensland Children's Medical Research Institute, Royal Children's Hospital</s1><s2>Herston, Queensland</s2><s3>AUS</s3><sZ>4 aut.</sZ></fA14><fA14 i1="04"><s1>Nutrition and Health Sciences and Hubert Department of Global Health, Rollins School of Public Health, Emory University</s1><s2>Atlanta, GA</s2><s3>USA</s3><sZ>6 aut.</sZ></fA14><fA20><s1>480-487</s1></fA20><fA21><s1>2013</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>8263</s2><s5>354000506523960290</s5></fA43><fA44><s0>0000</s0><s1>© 2013 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>44 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>13-0271512</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>The American journal of clinical nutrition</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Background: Early-life exposures to tobacco smoke and some dietary factors have been identified to induce epigenetic changes in genes involved in allergy and asthma development. Omega-3 (n-3) polyunsaturated fatty acid (PUFA) intake during pregnancy could modulate key cytokines and T helper (Th) cell maturation; however, little is known about the mechanism by which ω-3 PUFA could have a beneficial effect in preventing inflammatory disorders. Objective: We sought to test whether prenatal dietary supplementation with ω-3 PUFA during pregnancy may modulate epigenetic states in the infant immune system. Design: This study was based on a randomized intervention trial conducted in Mexican pregnant women supplemented daily with 400 mg docosahexaenoic acid (DHA) or a placebo from 18 to 22 wk of gestation to parturition. We applied quantitative profiling of DNA methylation states in Thl, Th2, Th17, and regulatory T-relevant genes as well as LINE1 repetitive elements of cord blood mononuclear cells (n = 261). Results: No significant difference in promoter methylation levels was shown between ω-3 PUFA-supplemented and control groups for the genes analyzed; however, ω-3 PUFA supplementation was associated with changes in methylation levels in LINE1 repetitive elements (P = 0.03) in infants of mothers who smoked during pregnancy. Furthermore, an association between the promoter methylation levels of IFNγ and IL13 was modulated by ω-3 PUFA supplementation (P = 0.06). Conclusions: Our results indicate that maternal supplementation with ω-3 PUFA during pregnancy may modulate global methylation levels and the Th1/Th2 balance in infants. Therefore, the epigenetic mechanisms could provide attractive targets for prenatal modulation and prevention of inflammatory disorders and potentially other related diseases in childhood and adulthood.</s0></fC01><fC02 i1="01" i2="X"><s0>002A16E</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>DNA</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>DNA</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>DNA</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Méthylation</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Methylation</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Metilación</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Système immunitaire</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Immune system</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Sistema inmunitario</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Supplémentation</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Supplementation</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Suplementación</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Gestation</s0><s5>07</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Pregnancy</s0><s5>07</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Gestación</s0><s5>07</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Nutrition</s0><s5>08</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Nutrition</s0><s5>08</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Nutrición</s0><s5>08</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Nourrisson</s0><s5>72</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Infant</s0><s5>72</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Lactante</s0><s5>72</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Alimentation</s0><s5>20</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Feeding</s0><s5>20</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Alimentación</s0><s5>20</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Homme</s0></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Human</s0></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Hombre</s0></fC07><fN21><s1>259</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Australie</li><li>France</li><li>Mexique</li><li>États-Unis</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Lyon</li></settlement></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Lee, Ho Sun" sort="Lee, Ho Sun" uniqKey="Lee H" first="Ho-Sun" last="Lee">Ho-Sun Lee</name></region><name sortKey="Biessy, Carine" sort="Biessy, Carine" uniqKey="Biessy C" first="Carine" last="Biessy">Carine Biessy</name><name sortKey="Herceg, Zdenko" sort="Herceg, Zdenko" uniqKey="Herceg Z" first="Zdenko" last="Herceg">Zdenko Herceg</name><name sortKey="Hernandez Vargas, Hector" sort="Hernandez Vargas, Hector" uniqKey="Hernandez Vargas H" first="Hector" last="Hernandez-Vargas">Hector Hernandez-Vargas</name><name sortKey="Romieu, Isabelle" sort="Romieu, Isabelle" uniqKey="Romieu I" first="Isabelle" last="Romieu">Isabelle Romieu</name></country><country name="Mexique"><noRegion><name sortKey="Barraza Villarreal, Albino" sort="Barraza Villarreal, Albino" uniqKey="Barraza Villarreal A" first="Albino" last="Barraza-Villarreal">Albino Barraza-Villarreal</name></noRegion><name sortKey="Romieu, Isabelle" sort="Romieu, Isabelle" uniqKey="Romieu I" first="Isabelle" last="Romieu">Isabelle Romieu</name></country><country name="Australie"><noRegion><name sortKey="Sly, Peter D" sort="Sly, Peter D" uniqKey="Sly P" first="Peter D." last="Sly">Peter D. Sly</name></noRegion></country><country name="États-Unis"><noRegion><name sortKey="Ramakrishnan, Usha" sort="Ramakrishnan, Usha" uniqKey="Ramakrishnan U" first="Usha" last="Ramakrishnan">Usha Ramakrishnan</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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