Modulation of DNA methylation states and infant immune system by dietary supplementation with ω-3 PUFA during pregnancy in an intervention study
Identifieur interne : 000782 ( PascalFrancis/Checkpoint ); précédent : 000781; suivant : 000783Modulation of DNA methylation states and infant immune system by dietary supplementation with ω-3 PUFA during pregnancy in an intervention study
Auteurs : Ho-Sun Lee [France] ; Albino Barraza-Villarreal [Mexique] ; Hector Hernandez-Vargas [France] ; Peter D. Sly [Australie] ; Carine Biessy [France] ; Usha Ramakrishnan [États-Unis] ; Isabelle Romieu [France, Mexique] ; Zdenko Herceg [France]Source :
- The American journal of clinical nutrition [ 0002-9165 ] ; 2013.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Nutrition.
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- KwdEn :
Abstract
Background: Early-life exposures to tobacco smoke and some dietary factors have been identified to induce epigenetic changes in genes involved in allergy and asthma development. Omega-3 (n-3) polyunsaturated fatty acid (PUFA) intake during pregnancy could modulate key cytokines and T helper (Th) cell maturation; however, little is known about the mechanism by which ω-3 PUFA could have a beneficial effect in preventing inflammatory disorders. Objective: We sought to test whether prenatal dietary supplementation with ω-3 PUFA during pregnancy may modulate epigenetic states in the infant immune system. Design: This study was based on a randomized intervention trial conducted in Mexican pregnant women supplemented daily with 400 mg docosahexaenoic acid (DHA) or a placebo from 18 to 22 wk of gestation to parturition. We applied quantitative profiling of DNA methylation states in Thl, Th2, Th17, and regulatory T-relevant genes as well as LINE1 repetitive elements of cord blood mononuclear cells (n = 261). Results: No significant difference in promoter methylation levels was shown between ω-3 PUFA-supplemented and control groups for the genes analyzed; however, ω-3 PUFA supplementation was associated with changes in methylation levels in LINE1 repetitive elements (P = 0.03) in infants of mothers who smoked during pregnancy. Furthermore, an association between the promoter methylation levels of IFNγ and IL13 was modulated by ω-3 PUFA supplementation (P = 0.06). Conclusions: Our results indicate that maternal supplementation with ω-3 PUFA during pregnancy may modulate global methylation levels and the Th1/Th2 balance in infants. Therefore, the epigenetic mechanisms could provide attractive targets for prenatal modulation and prevention of inflammatory disorders and potentially other related diseases in childhood and adulthood.
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<front><div type="abstract" xml:lang="en">Background: Early-life exposures to tobacco smoke and some dietary factors have been identified to induce epigenetic changes in genes involved in allergy and asthma development. Omega-3 (n-3) polyunsaturated fatty acid (PUFA) intake during pregnancy could modulate key cytokines and T helper (Th) cell maturation; however, little is known about the mechanism by which ω-3 PUFA could have a beneficial effect in preventing inflammatory disorders. Objective: We sought to test whether prenatal dietary supplementation with ω-3 PUFA during pregnancy may modulate epigenetic states in the infant immune system. Design: This study was based on a randomized intervention trial conducted in Mexican pregnant women supplemented daily with 400 mg docosahexaenoic acid (DHA) or a placebo from 18 to 22 wk of gestation to parturition. We applied quantitative profiling of DNA methylation states in Thl, Th2, Th17, and regulatory T-relevant genes as well as LINE1 repetitive elements of cord blood mononuclear cells (n = 261). Results: No significant difference in promoter methylation levels was shown between ω-3 PUFA-supplemented and control groups for the genes analyzed; however, ω-3 PUFA supplementation was associated with changes in methylation levels in LINE1 repetitive elements (P = 0.03) in infants of mothers who smoked during pregnancy. Furthermore, an association between the promoter methylation levels of IFNγ and IL13 was modulated by ω-3 PUFA supplementation (P = 0.06). Conclusions: Our results indicate that maternal supplementation with ω-3 PUFA during pregnancy may modulate global methylation levels and the Th1/Th2 balance in infants. Therefore, the epigenetic mechanisms could provide attractive targets for prenatal modulation and prevention of inflammatory disorders and potentially other related diseases in childhood and adulthood.</div>
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<s5>04</s5>
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<fC03 i1="04" i2="X" l="ENG"><s0>Supplementation</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Suplementación</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Gestation</s0>
<s5>07</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Pregnancy</s0>
<s5>07</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Gestación</s0>
<s5>07</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Nutrition</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Nutrition</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Nutrición</s0>
<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Nourrisson</s0>
<s5>72</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Infant</s0>
<s5>72</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Lactante</s0>
<s5>72</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Alimentation</s0>
<s5>20</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Feeding</s0>
<s5>20</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Alimentación</s0>
<s5>20</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Homme</s0>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Human</s0>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Hombre</s0>
</fC07>
<fN21><s1>259</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>Mexique</li>
<li>États-Unis</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Rhône-Alpes</li>
</region>
<settlement><li>Lyon</li>
</settlement>
</list>
<tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Lee, Ho Sun" sort="Lee, Ho Sun" uniqKey="Lee H" first="Ho-Sun" last="Lee">Ho-Sun Lee</name>
</region>
<name sortKey="Biessy, Carine" sort="Biessy, Carine" uniqKey="Biessy C" first="Carine" last="Biessy">Carine Biessy</name>
<name sortKey="Herceg, Zdenko" sort="Herceg, Zdenko" uniqKey="Herceg Z" first="Zdenko" last="Herceg">Zdenko Herceg</name>
<name sortKey="Hernandez Vargas, Hector" sort="Hernandez Vargas, Hector" uniqKey="Hernandez Vargas H" first="Hector" last="Hernandez-Vargas">Hector Hernandez-Vargas</name>
<name sortKey="Romieu, Isabelle" sort="Romieu, Isabelle" uniqKey="Romieu I" first="Isabelle" last="Romieu">Isabelle Romieu</name>
</country>
<country name="Mexique"><noRegion><name sortKey="Barraza Villarreal, Albino" sort="Barraza Villarreal, Albino" uniqKey="Barraza Villarreal A" first="Albino" last="Barraza-Villarreal">Albino Barraza-Villarreal</name>
</noRegion>
<name sortKey="Romieu, Isabelle" sort="Romieu, Isabelle" uniqKey="Romieu I" first="Isabelle" last="Romieu">Isabelle Romieu</name>
</country>
<country name="Australie"><noRegion><name sortKey="Sly, Peter D" sort="Sly, Peter D" uniqKey="Sly P" first="Peter D." last="Sly">Peter D. Sly</name>
</noRegion>
</country>
<country name="États-Unis"><noRegion><name sortKey="Ramakrishnan, Usha" sort="Ramakrishnan, Usha" uniqKey="Ramakrishnan U" first="Usha" last="Ramakrishnan">Usha Ramakrishnan</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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