Abacavir use and risk of recurrent myocardial infarction: the D: A: D Study.
Identifieur interne : 005028 ( Ncbi/Merge ); précédent : 005027; suivant : 005029Abacavir use and risk of recurrent myocardial infarction: the D: A: D Study.
Auteurs : Caroline A. Sabin [Pays-Bas] ; Lene Ryom ; Antonella D'Arminio Monforte ; Camilla I. Hatleberg ; Christian Pradier ; Wafaa El-Sadr ; Ole Kirk ; Rainer Weber ; Andrew N. Phillips ; Amanda Mocroft ; Fabrice Bonnet ; Matthew Law ; Stephane De Wit ; Peter Reiss ; Jens D. LundgrenSource :
- AIDS (London, England) [ 1473-5571 ] ; 2017.
Abstract
To investigate the association between abacavir (ABC) use and recurrent myocardial infarction (MI) among HIV-positive people with a prior MI.
DOI: 10.1097/QAD.0000000000001666
PubMed: 29028664
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<front><div type="abstract" xml:lang="en">To investigate the association between abacavir (ABC) use and recurrent myocardial infarction (MI) among HIV-positive people with a prior MI.</div>
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<ArticleTitle>Abacavir use and risk of recurrent myocardial infarction: the D: A: D Study.</ArticleTitle>
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<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To investigate the association between abacavir (ABC) use and recurrent myocardial infarction (MI) among HIV-positive people with a prior MI.</AbstractText>
<AbstractText Label="DESIGN" NlmCategory="METHODS">International multi-cohort collaboration with follow-up from 1999-2016.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">The rate of recurrent MI was described among D:A:D participants who experienced an index MI whilst in the study, and who remained under follow-up beyond 28 days after this MI. Follow-up was considered to the date of next MI, death, 01/Feb/2016 or 6 months after last clinic visit. Poisson regression models considered associations between recurrent MI and exposure to ABC (use at index MI, current post-MI exposure and cumulative exposure), before and after adjusting for calendar year.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The 984 individuals who experienced an index MI during the study (91.3% male, median age 51 at index MI) were followed for 5312 person-years (PY) over which time there were 136 recurrent MIs (rate 2.56/100 PY, 95% Confidence Interval 2.13-2.99). Rates were 2.40 (1.71-3.09) and 2.65 (2.10-3.21)/100 PY in those who were and were not on ABC, respectively, at the index MI, and 2.90 (2.01-3.78) and 2.44 (1.95-2.93)/100 PY in those who were and were not currently receiving ABC, respectively, post-MI. No association was seen with recurrent MI and either cumulative exposure to ABC (RR=0.86 [0.68-1.10]/5 years), receipt of ABC at index MI (0.90 [0.63-1.29]) nor recent post-MI exposure to ABC (1.19 [0.82-1.71]).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Among people with a previous MI, there was no evidence for an association between use of ABC post-MI and an elevated risk of a recurrent MI.</AbstractText>
</Abstract>
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